Showing entry for Oxytocin receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009442
Protein NameOxytocin receptor
Uniport IdP30559
GeneOXTR
Gene Id5021
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0048565 digestive tract development
Biological Process GO:0042755 eating behavior
Biological Process GO:0070371 ERK1 and ERK2 cascade
Biological Process GO:0044849 estrous cycle
Biological Process GO:0007565 female pregnancy
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007507 heart development
Biological Process GO:0007595 lactation
Biological Process GO:0042711 maternal behavior
Biological Process GO:0060137 maternal process involved in parturition
Biological Process GO:0007613 memory
Biological Process GO:0006936 muscle contraction
Biological Process GO:0060455 negative regulation of gastric acid secretion
Biological Process GO:0045777 positive regulation of blood pressure
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0010701 positive regulation of norepinephrine secretion
Biological Process GO:0060406 positive regulation of penile erection
Biological Process GO:0051965 positive regulation of synapse assembly
Biological Process GO:0032230 positive regulation of synaptic transmission, GABAergic
Biological Process GO:0051968 positive regulation of synaptic transmission, glutamatergic
Biological Process GO:0070474 positive regulation of uterine smooth muscle contraction
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0001992 regulation of systemic arterial blood pressure by vasopressin
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0034059 response to anoxia
Biological Process GO:0042220 response to cocaine
Biological Process GO:0034097 response to cytokine
Biological Process GO:0042493 response to drug
Biological Process GO:0032355 response to estradiol
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0032570 response to progesterone
Biological Process GO:0030431 sleep
Biological Process GO:0035176 social behavior
Biological Process GO:0042713 sperm ejaculation
Biological Process GO:0001967 suckling behavior
Biological Process GO:0021537 telencephalon development
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0004990 oxytocin receptor activity
molecular function GO:0042277 peptide binding
molecular function GO:0017046 peptide hormone binding
molecular function GO:0005000 vasopressin receptor activity
cellular component GO:0005912 adherens junction
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005902 microvillus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000846 BXGD000015 Agenesis
C0001726 BXGD000072 Affective Symptoms Behavior and Behavior Mechanisms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002020 BXGD000098 Alexithymia Behavior and Behavior Mechanisms
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0003431 BXGD000190 Antisocial Personality Disorder Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003477 BXGD000196 Separation Anxiety Disorder Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0004930 BXGD000294 Behavior Disorders Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008060 BXGD000516 child abuse behavior
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013390 BXGD000828 Dysmenorrhea Pathological Conditions, Signs and Symptoms
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015458 BXGD000993 Facial Hemiatrophy Nervous System Diseases; Stomatognathic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020507 BXGD001413 Hyperplasia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0029121 BXGD002112 Oppositional Defiant Disorder Mental Disorders
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0031572 BXGD002307 Phobia, Social Mental Disorders
C0033038 BXGD002390 Premature Ejaculation Male Urogenital Diseases; Mental Disorders
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038358 BXGD002748 Gastric ulcer Digestive System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042693 BXGD002996 Violence
C0042769 BXGD002999 Virus Diseases Infections
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0149654 BXGD003343 Conduct Disorder Mental Disorders
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221074 BXGD004388 Depression, Postpartum Female Urogenital Diseases and Pregnancy Complications; Mental Disorders
C0233397 BXGD004574 Psychological symptom
C0233401 BXGD004575 Psychiatric symptom
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233523 BXGD004586 Antisocial behavior Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0236792 BXGD004830 Asperger Syndrome Mental Disorders
C0237123 BXGD004845 Alcohol or Other Drugs use
C0242184 BXGD005140 Hypoxia Pathological Conditions, Signs and Symptoms
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0268318 BXGD005896 Cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0338986 BXGD007219 Atypical autism Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0424166 BXGD008521 Social Anxiety Behavior and Behavior Mechanisms
C0429468 BXGD008651 Anovulatory (finding) Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0432215 BXGD008739 Progressive pseudorheumatoid dysplasia Musculoskeletal Diseases
C0438696 BXGD008805 Suicidal Behavior and Behavior Mechanisms
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0748073 BXGD010191 psychosocial stressor
C0852733 BXGD010952 Completed Suicide
C0852862 BXGD010953 Perinatal brain damage
C0860472 BXGD011227 Adolescent antisocial behaviour
C0871189 BXGD011312 Psychotic symptom
C0871388 BXGD011314 social stress Behavior and Behavior Mechanisms
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919568 BXGD011429 Impatience
C1112157 BXGD011648 Intrauterine infection
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1337011 BXGD012874 Well Differentiated Pancreatic Endocrine Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1524032 BXGD013256 Depression and Suicide
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1563705 BXGD013386 Nephrogenic Diabetes Insipidus, Type I Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1698581 BXGD013519 Rokitansky Kuster Hauser syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1836230 BXGD014099 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
C1836231 BXGD014100 HIV-1, RESISTANCE TO
C1836232 BXGD014101 ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
C1836233 BXGD014102 AIDS, PROGRESSION TO
C1842981 BXGD014547 NEUROTICISM Behavior and Behavior Mechanisms
C2063866 BXGD016906 Depressive Disorder, Treatment-Resistant Mental Disorders
C2267227 BXGD017015 Bulimia Nervosa Mental Disorders
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2363741 BXGD017100 HIV-1 infection
C2931337 BXGD018004 Chromosome 3, monosomy 3p25 Pathological Conditions, Signs and Symptoms
C2931455 BXGD018023 Prosopagnosia, hereditary Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C3840214 BXGD019795 High-functioning autism Mental Disorders
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284586 BXGD022439 Perinatal depression in mother Mental Disorders
C4296683 BXGD022516 Emotional neglect
C4316909 BXGD022713 Marijuana Use Mental Disorders; Behavior and Behavior Mechanisms
C4505163 BXGD022954 Food Addiction Mental Disorders; Behavior and Behavior Mechanisms
C4531100 BXGD023187 Negative affectivity
C4706503 BXGD023697 Distal monosomy 3p syndrome
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000982 L-Homocysteine 135.19
BXGC0005683 Quercetin 302.24
BXGC0005874 Racemethionine 149.21
BXGC0006183 L-Cystine 240.3
BXGC0023321 Quercetin Dihydrate 302.04
BXGC0038316 Cholesterol 386.35
BXGC0042395 (4Ar,5R,6As,6Br,10S,12Ar)-5,10-Dihydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid 472.36
BXGC0042462 Cysteine 121.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein