adisease

Showing entry for Aplastic Anemia

General Disease Information
BXGD Id	BXGD000134
Disease Name	Aplastic Anemia
Disease CUI Id	C0002874
MeSH Codes	C15
Disease Class Name	Hemic and Lymphatic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001871
Human Phenotype Ontology Term	Abnormality of blood and blood-forming tissues
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00182	BXGT003889	Galectin-9	3965	reviewed	Signaling
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14773	BXGT004096	Tripeptidyl-peptidase 1	1200	reviewed	Enzyme
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O75521	BXGT005134	Enoyl-CoA delta isomerase 2, mitochondrial	10455	reviewed	Enzyme modulator
O76094	BXGT005177	Signal recognition particle subunit SRP72	6731	reviewed
O95390	BXGT005377	Growth/differentiation factor 11	10220	reviewed	Signaling
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P00915	BXGT005689	Carbonic anhydrase 1	759	reviewed
P01008	BXGT005713	Antithrombin-III	462	reviewed	Enzyme modulator
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02724	BXGT005934	Glycophorin-A	2993	reviewed
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P02818	BXGT005969	Osteocalcin	632	reviewed
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05106	BXGT006315	Integrin beta-3	3690	reviewed	Receptor
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P08174	BXGT006739	Complement decay-accelerating factor	1604	reviewed
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08514	BXGT006781	Integrin alpha-IIb	3674	reviewed
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08700	BXGT006816	Interleukin-3	3562	reviewed
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16109	BXGT008194	P-selectin	6403	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P24158	BXGT008951	Myeloblastin	5657	reviewed	Enzyme
P27352	BXGT009174	Cobalamin binding intrinsic factor	2694	reviewed
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31997	BXGT009593	Carcinoembryonic antigen-related cell adhesion molecule 8	1088	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51684	BXGT010880	C-C chemokine receptor type 6	1235	reviewed	G-protein coupled receptor
P55040	BXGT011099	GTP-binding protein GEM	2669	reviewed
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61011	BXGT011346	Signal recognition particle 54 kDa protein	6729	reviewed	Nucleic acid binding
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P62258	BXGT011415	14-3-3 protein epsilon	7531	reviewed	Chaperone
P78556	BXGT011849	C-C motif chemokine 20	6364	reviewed	Signaling
P81172	BXGT011935	Hepcidin	57817	reviewed
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q13191	BXGT013325	E3 ubiquitin-protein ligase CBL-B	868	reviewed	Enzyme
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13574	BXGT013379	Diacylglycerol kinase zeta	8525	reviewed	Enzyme
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14469	BXGT013473	Transcription factor HES-1	3280	reviewed	Transcription factor
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15554	BXGT013577	Telomeric repeat-binding factor 2	7014	reviewed
Q15582	BXGT013581	Transforming growth factor-beta-induced protein ig-h3	7045	reviewed	Signaling
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q59FK2	BXGT015276	Selenocysteine lyase variant	51540	unreviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8IW19	BXGT018351	Aprataxin and PNK-like factor	200558	reviewed
Q8TDQ0	BXGT018810	Hepatitis A virus cellular receptor 2	84868	reviewed
Q96I15	BXGT019674	Selenocysteine lyase	51540	reviewed	Enzyme
Q9BX66	BXGT020158	Sorbin and SH3 domain-containing protein 1	10580	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9NYA1	BXGT021254	Sphingosine kinase 1	8877	reviewed	Kinase
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UIQ6	BXGT021721	Leucyl-cystinyl aminopeptidase	4012	reviewed	Enzyme
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q9UM82	BXGT023181	Spermatogenesis-associated protein 2	9825	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}