| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Vorinostat | hsa00030 | Pentose phosphate pathway | 1.69E-02 | 2 | P60891, P37837 | PRPS1, TALDO1 | More | | | Vorinostat | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Vorinostat | hsa00061 | Fatty acid biosynthesis | 4.07E-02 | 1 | P33121 | ACSL1 | More | | | Vorinostat | hsa00190 | Oxidative phosphorylation | 3.73E-04 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Vorinostat | hsa00220 | Arginine biosynthesis | 3.83E-02 | 2 | P05089, P49448 | ARG1, GLUD2 | More | | | Vorinostat | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 3.43E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Vorinostat | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Vorinostat | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Vorinostat | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Vorinostat | hsa00600 | Sphingolipid metabolism | 2.68E-02 | 2 | P07602, Q13510 | PSAP, ASAH1 | More | | | Vorinostat | hsa00630 | Glyoxylate and dicarboxylate metabolism | 2.48E-02 | 2 | P40926, P15104 | MDH2, GLUL | More | | | Vorinostat | hsa00750 | Vitamin B6 metabolism | 3.56E-02 | 1 | O00764 | PDXK | More | | | Vorinostat | hsa00830 | Retinol metabolism | 2.67E-03 | 4 | P00325, P00352, Q9BPW9, O75911 | ADH1B, ALDH1A1, DHRS9, DHRS3 | More | | | Vorinostat | hsa00860 | Porphyrin and chlorophyll metabolism | 1.69E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Vorinostat | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.12E-02 | 1 | P14868 | DARS | More | | | Vorinostat | hsa01100 | Metabolic pathways | 1.25E-02 | 11 | O14521, Q13370, P11712, P24666, P23743, O60701, P33121, Q9NY28, P09960, Q9Y2B2, Q16718 | SDHD, PDE3B, CYP2C9, ACP1, DGKA, UGDH, ACSL1, GALNT8, LTA4H, PIGL, NDUFA5 | More | | | Vorinostat | hsa01210 | 2-Oxocarboxylic acid metabolism | 3.56E-02 | 1 | P50213 | IDH3A | More | | | Vorinostat | hsa01230 | Biosynthesis of amino acids | 3.59E-02 | 3 | P60891, Q99707, P37837 | PRPS1, MTR, TALDO1 | More | | | Vorinostat | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa01522 | Endocrine resistance | 3.41E-02 | 6 | P14780, P22694, Q9UM47, P08069, P10415, Q13323 | MMP9, PRKACB, NOTCH3, IGF1R, BCL2, BIK | More | | | Vorinostat | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Vorinostat | hsa03008 | Ribosome biogenesis in eukaryotes | 1.37E-03 | 4 | O14980, O60832, P78345, Q9BVP2 | XPO1, DKC1, RPP38, GNL3 | More | | | Vorinostat | hsa03010 | Ribosome | 1.88E-02 | 6 | P62753, P25398, P32969, P62829, P18077, P36578 | RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4 | More | | | Vorinostat | hsa03013 | RNA transport | 2.48E-05 | 12 | O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5 | XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3 | More | | | Vorinostat | hsa03020 | RNA polymerase | 3.59E-02 | 2 | P30876, P62487 | POLR2B, POLR2G | More | | | Vorinostat | hsa03022 | Basal transcription factors | 2.17E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Vorinostat | hsa03040 | Spliceosome | 1.46E-02 | 4 | P17844, P51991, P61978, P11142 | DDX5, HNRPA3, HNRPK, HSPA8 | More | | | Vorinostat | hsa03050 | Proteasome | 1.21E-02 | 1 | P28074 | PSMB5 | More | | | Vorinostat | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Vorinostat | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04014 | Ras signaling pathway | 3.65E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04015 | Rap1 signaling pathway | 3.24E-03 | 4 | P08069, P25116, Q8TEU7, P08514 | IGF1R, F2R, RAPGEF6, ITGA2B | More | | | Vorinostat | hsa04020 | Calcium signaling pathway | 4.93E-02 | 3 | P17252, P25116, P20020 | PRKCA, F2R, ATP2B1 | More | | | Vorinostat | hsa04022 | cGMP-PKG signaling pathway | 1.05E-02 | 3 | P24844, Q8WYR1, Q15746 | MYL9, PIK3R5, MYLK | More | | | Vorinostat | hsa04024 | cAMP signaling pathway | 2.04E-03 | 5 | P20020, Q13370, P48058, P25116, P24844 | ATP2B1, PDE3B, GRIA4, F2R, MYL9 | More | | | Vorinostat | hsa04060 | Cytokine-cytokine receptor interaction | 5.34E-03 | 11 | P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4 | More | | | Vorinostat | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.70E-03 | 8 | P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB | More | | | Vorinostat | hsa04062 | Chemokine signaling pathway | 4.01E-04 | 13 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK | More | | | Vorinostat | hsa04064 | NF-kappa B signaling pathway | 1.78E-05 | 17 | P10415, Q13489, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, P24522, P09341, P19875, Q06643 | BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, GADD45A, CXCL1, CXCL2, LTB | More | | | Vorinostat | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04071 | Sphingolipid signaling pathway | 4.27E-07 | 10 | P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2 | More | | | Vorinostat | hsa04072 | Phospholipase D signaling pathway | 7.52E-04 | 11 | P42338, Q9UQC2, P43657, P25116, P25024, P25025, P19174, P17252, Q8WYR1, Q08828, P23743 | PIK3CB, GAB2, P2RY5, F2R, CXCR1, CXCR2, PLCG1, PRKCA, PIK3R5, ADCY1, DGKA | More | | | Vorinostat | hsa04080 | Neuroactive ligand-receptor interaction | 4.72E-02 | 8 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1 | More | | | Vorinostat | hsa04114 | Oocyte meiosis | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04136 | Autophagy - other | 5.92E-03 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Vorinostat | hsa04140 | Autophagy - animal | 6.54E-02 | 6 | P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759 | IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Vorinostat | hsa04141 | Protein processing in endoplasmic reticulum | 3.42E-04 | 7 | P18848, Q15437, O60337, Q99941, P11142, P07900, Q9NR31 | ATF4, SEC23B, MARH6, CREBL1, HSPA8, HSP90AA1, SAR1A | More | | | Vorinostat | hsa04145 | Phagosome | 1.08E-02 | 8 | O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765 | FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB | More | | | Vorinostat | hsa04146 | Peroxisome | 2.42E-02 | 5 | O43933, P56589, Q9UKG9, O75521, P33121 | PEX1, PEX3, CROT, ECI2, ACSL1 | More | | | Vorinostat | hsa04150 | mTOR signaling pathway | 2.32E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04151 | PI3K-Akt signaling pathway | 4.05E-04 | 12 | P62753, O43521, P27348, Q13362, P07900, Q8WYR1, P22105, P23458, Q99941, P18848, O00141, Q6ZUJ8 | RPS6, BCL2L11, YWHAQ, PPP2R5C, HSP90AA1, PIK3R5, TNXB, JAK1, CREBL1, ATF4, SGK, PIK3AP1 | More | | | Vorinostat | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04211 | Longevity regulating pathway | 5.33E-03 | 4 | P08069, P51828, Q99941, P18848 | IGF1R, ADCY7, CREBL1, ATF4 | More | | | Vorinostat | hsa04213 | Longevity regulating pathway - multiple species | 3.72E-04 | 7 | P42338, P08069, Q9Y4H2, Q08828, P0DMV8, P11142, Q13547 | PIK3CB, IGF1R, IRS2, ADCY1, HSPA1A, HSPA8, HDAC1 | More | | | Vorinostat | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | | | Vorinostat | hsa04217 | Necroptosis | 7.72E-06 | 14 | P01568, Q13489, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, Q13557, O43633, Q08752 | IFNA21, BIRC3, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, CAMK2D, CHMP2A, PPID | More | | | Vorinostat | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.14E-03 | 7 | P09493, P51828, Q99941, P18848, Q13557, P17252, P20020 | TPM1, ADCY7, CREBL1, ATF4, CAMK2D, PRKCA, ATP2B1 | More | | | Vorinostat | hsa04270 | Vascular smooth muscle contraction | 2.56E-03 | 5 | Q15746, P24844, Q08828, P35579, P35318 | MYLK, MYL9, ADCY1, MYH9, ADM | More | | | Vorinostat | hsa04340 | Hedgehog signaling pathway | 1.40E-03 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Vorinostat | hsa04360 | Axon guidance | 1.66E-02 | 3 | P20827, P23528, Q06124 | EFNA1, CFL1, PTPN11 | More | | | Vorinostat | hsa04390 | Hippo signaling pathway | 1.20E-03 | 6 | P63261, P84022, Q13485, P04628, O43623, Q13489 | ACTG1, SMAD3, SMAD4, WNT1, SNAI2, BIRC3 | More | | | Vorinostat | hsa04510 | Focal adhesion | 5.64E-03 | 4 | P08514, Q15746, P24844, P08069 | ITGA2B, MYLK, MYL9, IGF1R | More | | | Vorinostat | hsa04512 | ECM-receptor interaction | 2.44E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Vorinostat | hsa04514 | Cell adhesion molecules | 4.65E-02 | 2 | P16109, O00501 | SELP, CLDN5 | More | | | Vorinostat | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04530 | Tight junction | 7.42E-04 | 4 | Q8TEU7, O00501, Q14247, P24844 | RAPGEF6, CLDN5, CTTN, MYL9 | More | | | Vorinostat | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 2.53E-03 | 4 | P04628, P40189, P08069, P14653 | WNT1, IL6ST, IGF1R, HOXB1 | More | | | Vorinostat | hsa04610 | Complement and coagulation cascades | 6.67E-04 | 3 | P25116, P0C0L4, P10909 | F2R, C4A, CLU | More | | | Vorinostat | hsa04611 | Platelet activation | 1.55E-06 | 7 | P25116, Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P07359 | F2R, TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, GP1BA | More | | | Vorinostat | hsa04612 | Antigen processing and presentation | 1.36E-03 | 9 | P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Vorinostat | hsa04613 | Neutrophil extracellular trap formation | 1.86E-05 | 16 | P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Vorinostat | hsa04621 | NOD-like receptor signaling pathway | 1.45E-03 | 13 | Q16539, Q14643, P23458, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838 | MAPK14, ITPR1, JAK1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4 | More | | | Vorinostat | hsa04623 | Cytosolic DNA-sensing pathway | 3.15E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Vorinostat | hsa04630 | JAK-STAT signaling pathway | 4.43E-02 | 3 | P48551, P40189, Q06124 | IFNAR2, IL6ST, PTPN11 | More | | | Vorinostat | hsa04640 | Hematopoietic cell lineage | 1.03E-05 | 11 | P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765 | ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB | More | | | Vorinostat | hsa04650 | Natural killer cell mediated cytotoxicity | 2.48E-05 | 10 | P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715 | PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1 | More | | | Vorinostat | hsa04657 | IL-17 signaling pathway | 3.76E-04 | 10 | P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584 | HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1B | More | | | Vorinostat | hsa04658 | Th1 and Th2 cell differentiation | 7.71E-11 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 |
| | Vorinostat | hsa04659 | Th17 cell differentiation | 5.24E-09 | 15 | P25963, Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P07766, P09693, P20963 | NFKBIA, PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, CD3E, CD3G, CD247 | More | | | Vorinostat | hsa04660 | T cell receptor signaling pathway | 2.07E-07 | 16 | P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 |
| | Vorinostat | hsa04664 | Fc epsilon RI signaling pathway | 4.73E-02 | 2 | Q9UQC2, P20292 | GAB2, ALOX5AP | More | | | Vorinostat | hsa04666 | Fc gamma R-mediated phagocytosis | 3.08E-02 | 5 | O75015, P06396, O14494, P14598, P17252 | FCGR3B, GSN, PLPP1, NCF1, PRKCA | More | | | Vorinostat | hsa04714 | Thermogenesis | 1.58E-03 | 7 | P51828, P62753, P33121, P12074, O15239, Q16718, O14521 | ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHD | More | | | Vorinostat | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Vorinostat | hsa04724 | Glutamatergic synapse | 2.94E-02 | 2 | P48058, Q9NSB8 | GRIA4, HOMER2 | More | | | Vorinostat | hsa04725 | Cholinergic synapse | 2.17E-02 | 3 | P51828, P18848, Q13557 | ADCY7, ATF4, CAMK2D | More | | | Vorinostat | hsa04726 | Serotonergic synapse | 1.64E-02 | 3 | P17252, P31645, P11712 | PRKCA, SLC6A4, CYP2C9 | More | | | Vorinostat | hsa04728 | Dopaminergic synapse | 4.78E-02 | 3 | Q99941, P18848, Q13557 | CREBL1, ATF4, CAMK2D | More | | | Vorinostat | hsa04730 | Long-term depression | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.24E-03 | 5 | P14778, P19174, P42338, P24723, Q04759 | IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ | More | | | Vorinostat | hsa04810 | Regulation of actin cytoskeleton | 1.38E-03 | 4 | P24844, Q15746, P08514, P25116 | MYL9, MYLK, ITGA2B, F2R | More | | | Vorinostat | hsa04911 | Insulin secretion | 4.03E-04 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Vorinostat | hsa04912 | GnRH signaling pathway | 2.17E-02 | 3 | P51828, P18848, Q13557 | ADCY7, ATF4, CAMK2D | More | | | Vorinostat | hsa04913 | Ovarian steroidogenesis | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04914 | Progesterone-mediated oocyte maturation | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa04915 | Estrogen signaling pathway | 8.00E-05 | 8 | Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, Q15788 | CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, NCOA1 | More | | | Vorinostat | hsa04918 | Thyroid hormone synthesis | 1.69E-03 | 4 | P51828, Q99941, P18848, P02768 | ADCY7, CREBL1, ATF4, ALB | More | | | Vorinostat | hsa04921 | Oxytocin signaling pathway | 6.84E-04 | 5 | Q15746, Q08828, P24844, Q96RR4, Q8WYR1 | MYLK, ADCY1, MYL9, CAMKK2, PIK3R5 | More | | | Vorinostat | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Vorinostat | hsa04924 | Renin secretion | 3.64E-02 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Vorinostat | hsa04925 | Aldosterone synthesis and secretion | 1.69E-03 | 4 | Q99941, P18848, P51828, Q13557 | CREBL1, ATF4, ADCY7, CAMK2D | More | | | Vorinostat | hsa04926 | Relaxin signaling pathway | 3.34E-02 | 3 | Q99941, P18848, P51828 | CREBL1, ATF4, ADCY7 | More | | | Vorinostat | hsa04927 | Cortisol synthesis and secretion | 4.16E-03 | 3 | Q99941, P18848, P51828 | CREBL1, ATF4, ADCY7 | More | | | Vorinostat | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.17E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | | Vorinostat | hsa04932 | Non-alcoholic fatty liver disease | 9.70E-03 | 4 | P18848, P01584, P13073, O15239 | ATF4, IL1B, COX4I1, NDUFA1 | More | | | Vorinostat | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.25E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Vorinostat | hsa04934 | Cushing syndrome | 1.12E-03 | 4 | Q99941, P18848, P51828, Q13557 | CREBL1, ATF4, ADCY7, CAMK2D | More | | | Vorinostat | hsa04935 | Growth hormone synthesis, secretion and action | 2.72E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | | Vorinostat | hsa04940 | Type I diabetes mellitus | 4.18E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Vorinostat | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 1.48E-02 | 2 | P20020, P17252 | ATP2B1, PRKCA | More | | | Vorinostat | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Vorinostat | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Vorinostat | hsa04970 | Salivary secretion | 4.83E-02 | 2 | P20020, P17252 | ATP2B1, PRKCA | More | | | Vorinostat | hsa04972 | Pancreatic secretion | 1.64E-03 | 4 | P20020, P17252, Q08828, P62491 | ATP2B1, PRKCA, ADCY1, RAB11A | More | | | Vorinostat | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Vorinostat | hsa04975 | Fat digestion and absorption | 3.43E-02 | 1 | O14494 | PLPP1 | More | | | Vorinostat | hsa05012 | Parkinson disease | 2.53E-02 | 5 | O15239, P13073, P05141, P18848, Q13557 | NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D | More | | | Vorinostat | hsa05016 | Huntington disease | 2.29E-03 | 9 | O15239, Q16718, O14521, P13073, P30876, P62487, P05141, O00268, Q13561 | NDUFA1, NDUFA5, SDHD, COX4I1, POLR2B, POLR2G, SLC25A5, TAF4, DCTN2 | More | | | Vorinostat | hsa05017 | Spinocerebellar ataxia | 2.43E-02 | 1 | P28074 | PSMB5 | More | | | Vorinostat | hsa05020 | Prion disease | 3.37E-03 | 7 | P13591, P01584, P11142, O15239, P13073, P18848, P05141 | NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5 | More | | | Vorinostat | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.89E-03 | 11 | O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, P17252, P01584, Q08752, Q13557 | NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, PRKCA, IL1B, PPID, CAMK2D | More | | | Vorinostat | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | | Vorinostat | hsa05031 | Amphetamine addiction | 6.41E-03 | 3 | Q13557, Q99941, P18848 | CAMK2D, CREBL1, ATF4 | More | | | Vorinostat | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.78E-03 | 5 | P09341, P19875, P19174, P25024, P25025 | CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Vorinostat | hsa05130 | Pathogenic Escherichia coli infection | 2.51E-02 | 3 | Q14247, O00501, P25116 | CTTN, CLDN5, F2R | More | | | Vorinostat | hsa05132 | Salmonella infection | 2.04E-02 | 4 | P25963, Q13489, P10415, Q9BQS8 | NFKBIA, BIRC3, BCL2, FYCO1 | More | | | Vorinostat | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Vorinostat | hsa05134 | Legionellosis | 6.38E-04 | 6 | P01584, P11215, P68104, P11142, P09341, P19875 | IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2 | More | | | Vorinostat | hsa05140 | Leishmaniasis | 2.68E-05 | 12 | P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4 | More | | | Vorinostat | hsa05143 | African trypanosomiasis | 1.31E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Vorinostat | hsa05144 | Malaria | 6.79E-03 | 6 | P69905, P68871, O60603, P01375, P35443, P26718 | HBA2, HBB, TLR2, TNF, THBS4, KLRK1 | More | | | Vorinostat | hsa05145 | Toxoplasmosis | 4.95E-04 | 6 | P25963, P10415, Q13489, P23458, Q8WYR1, P0DMV8 | NFKBIA, BCL2, BIRC3, JAK1, PIK3R5, HSPA1A | More | | | Vorinostat | hsa05146 | Amoebiasis | 2.49E-06 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | | Vorinostat | hsa05150 | Staphylococcus aureus infection | 1.65E-02 | 6 | P21730, P21462, O75015, P13765, Q16581, P49913 | C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP | More | | | Vorinostat | hsa05152 | Tuberculosis | 8.54E-03 | 9 | O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617 | FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1 | More | | | Vorinostat | hsa05161 | Hepatitis B | 9.85E-04 | 7 | Q99941, P18848, P25963, Q13485, P10415, P27348, P84022 | CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3 | More | | | Vorinostat | hsa05162 | Measles | 2.66E-03 | 5 | P23458, P0DMV8, P11142, P01584, Q9NP90 | JAK1, HSPA1A, HSPA8, IL1B, RAB9B | More | | | Vorinostat | hsa05168 | Herpes simplex virus 1 infection | 3.38E-03 | 12 | P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212 | More | | | Vorinostat | hsa05169 | Epstein-Barr virus infection | 4.84E-03 | 10 | P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247 | More | | | Vorinostat | hsa05171 | Coronavirus disease - COVID-19 | 9.72E-03 | 7 | P01584, P62753, P25398, P36578, P32969, P18077, P62829 | IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23 | More | | | Vorinostat | hsa05202 | Transcriptional misregulation in cancer | 6.44E-06 | 20 | Q12778, Q15532, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | | Vorinostat | hsa05203 | Viral carcinogenesis | 1.46E-02 | 4 | Q99941, P18848, P27348, P61978 | CREBL1, ATF4, YWHAQ, HNRPK | More | | | Vorinostat | hsa05205 | Proteoglycans in cancer | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa05210 | Colorectal cancer | 1.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Vorinostat | hsa05212 | Pancreatic cancer | 3.52E-02 | 2 | P84022, Q13485 | SMAD3, SMAD4 | More | | | Vorinostat | hsa05214 | Glioma | 9.95E-03 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa05220 | Chronic myeloid leukemia | 1.25E-02 | 3 | Q13485, P25963, P84022 | SMAD4, NFKBIA, SMAD3 | More | | | Vorinostat | hsa05222 | Small cell lung cancer | 1.50E-02 | 3 | Q13489, P10415, P25963 | BIRC3, BCL2, NFKBIA | More | | | Vorinostat | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Vorinostat | hsa05226 | Gastric cancer | 2.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Vorinostat | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2.33E-04 | 8 | P42338, P19174, P07766, P20963, P09693, P06239, Q04759, P01730 | PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4 | More | | | Vorinostat | hsa05310 | Asthma | 9.08E-04 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Vorinostat | hsa05321 | Inflammatory bowel disease | 1.43E-05 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Vorinostat | hsa05322 | Systemic lupus erythematosus | 2.82E-02 | 8 | O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455 | FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB | More | | | Vorinostat | hsa05332 | Graft-versus-host disease | 8.14E-06 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Vorinostat | hsa05340 | Primary immunodeficiency | 2.19E-02 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Vorinostat | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Vorinostat | hsa05415 | Diabetic cardiomyopathy | 1.42E-04 | 10 | P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406 | PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDH | More | | | Vorinostat | hsa05416 | Viral myocarditis | 2.30E-02 | 2 | P10747, P63261 | CD28, ACTG1 | More | |
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