PharmaCoNets of Tetrabenazine (SPCN: 23.90 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Deutetrabenazinehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Deutetrabenazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Deutetrabenazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Deutetrabenazinehsa00591Linoleic acid metabolism1.34E-031P11712CYP2C9More
Deutetrabenazinehsa00630Glyoxylate and dicarboxylate metabolism6.94E-032P40925, P15104MDH1, GLULMore
Deutetrabenazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Deutetrabenazinehsa00980Metabolism of xenobiotics by cytochrome P4501.04E-042P78417, P11712GSTO1, CYP2C9More
Deutetrabenazinehsa00982Drug metabolism - cytochrome P4501.04E-042P11712, P78417CYP2C9, GSTO1More
Deutetrabenazinehsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Deutetrabenazinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Deutetrabenazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Deutetrabenazinehsa03040Spliceosome4.87E-037O43143, P08579, P26368, Q13595, Q07955, P84103, Q13243DHX15, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS3, SFRS5More
Deutetrabenazinehsa03050Proteasome1.63E-031P55036PSMD4More
Deutetrabenazinehsa04062Chemokine signaling pathway3.81E-026P07948, P62873, P63218, P50151, P43250, Q13009LYN, GNB1, GNG5, GNG10, GRK6, TIAM1More
Deutetrabenazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Deutetrabenazinehsa04217Necroptosis9.70E-0410P01375, P01568, P48023, Q13489, P98170, Q14765, P08238, P15104, Q99878, P21796TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT4, HSP90AB1, GLUL, H2AC14, VDAC1More
Deutetrabenazinehsa04371Apelin signaling pathway3.23E-047P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1More
Deutetrabenazinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Deutetrabenazinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Deutetrabenazinehsa04713Circadian entrainment1.78E-035O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Deutetrabenazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Deutetrabenazinehsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Deutetrabenazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Deutetrabenazinehsa04724Glutamatergic synapse1.11E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Deutetrabenazinehsa04725Cholinergic synapse9.51E-034P62873, P63218, P50151, Q16566GNB1, GNG5, GNG10, CAMK4More
Deutetrabenazinehsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Deutetrabenazinehsa04727GABAergic synapse2.45E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Deutetrabenazinehsa04744Phototransduction6.94E-032P62873, P0DP23GNB1, CALM1More
Deutetrabenazinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Deutetrabenazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Deutetrabenazinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Deutetrabenazinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Deutetrabenazinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Deutetrabenazinehsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Deutetrabenazinehsa05034Alcoholism4.45E-0511O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Deutetrabenazinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Deutetrabenazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Deutetrabenazinehsa05163Human cytomegalovirus infection2.00E-026P62873, P63218, P50151, P0DP23, P30101, P01568GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21More
Deutetrabenazinehsa05167Kaposi sarcoma-associated herpesvirus infection2.00E-026P01568, P62873, P63218, P50151, P07948, P0DP23IFNA21, GNB1, GNG5, GNG10, LYN, CALM1More
Deutetrabenazinehsa05168Herpes simplex virus 1 infection4.43E-028P01568, Q07955, P84103, Q13243, Q13489, P30101, Q13398, Q9NZL3IFNA21, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF224More
Deutetrabenazinehsa05170Human immunodeficiency virus 1 infection1.83E-027P62873, P63218, P50151, P0DP23, P30101, P01568, P23528GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, CFL1More
Deutetrabenazinehsa05200Pathways in cancer3.99E-0415Q13751, P08238, P43246, P84022, Q13485, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P01042LAMB3, HSP90AB1, MSH2, SMAD3, SMAD4, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, KNG1More
Deutetrabenazinehsa05203Viral carcinogenesis3.28E-033Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Deutetrabenazinehsa05204Chemical carcinogenesis2.96E-042P78417, P11712GSTO1, CYP2C9More
Deutetrabenazinehsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Deutetrabenazinehsa05212Pancreatic cancer3.28E-023P84022, Q13485, O75293SMAD3, SMAD4, GADD45BMore
Deutetrabenazinehsa05214Glioma3.28E-023P0DP23, Q16566, O75293CALM1, CAMK4, GADD45BMore
Deutetrabenazinehsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Deutetrabenazinehsa05225Hepatocellular carcinoma4.54E-023Q92922, P78417, Q9NPI1SMARCC1, GSTO1, BRD7More
Deutetrabenazinehsa05322Systemic lupus erythematosus1.73E-055P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Deutetrabenazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Deutetrabenazinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Deutetrabenazinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Tetrabenazinehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Tetrabenazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Tetrabenazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Tetrabenazinehsa00591Linoleic acid metabolism1.34E-031P11712CYP2C9More
Tetrabenazinehsa00630Glyoxylate and dicarboxylate metabolism6.94E-032P40925, P15104MDH1, GLULMore
Tetrabenazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tetrabenazinehsa00980Metabolism of xenobiotics by cytochrome P4501.04E-042P78417, P11712GSTO1, CYP2C9More
Tetrabenazinehsa00982Drug metabolism - cytochrome P4501.04E-042P11712, P78417CYP2C9, GSTO1More
Tetrabenazinehsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Tetrabenazinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Tetrabenazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tetrabenazinehsa03040Spliceosome4.87E-037O43143, P08579, P26368, Q13595, Q07955, P84103, Q13243DHX15, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS3, SFRS5More
Tetrabenazinehsa03050Proteasome1.63E-031P55036PSMD4More
Tetrabenazinehsa04062Chemokine signaling pathway3.81E-026P07948, P62873, P63218, P50151, P43250, Q13009LYN, GNB1, GNG5, GNG10, GRK6, TIAM1More
Tetrabenazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Tetrabenazinehsa04217Necroptosis9.70E-0410P01375, P01568, P48023, Q13489, P98170, Q14765, P08238, P15104, Q99878, P21796TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT4, HSP90AB1, GLUL, H2AC14, VDAC1More
Tetrabenazinehsa04371Apelin signaling pathway3.23E-047P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1More
Tetrabenazinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Tetrabenazinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Tetrabenazinehsa04713Circadian entrainment1.78E-035O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Tetrabenazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tetrabenazinehsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Tetrabenazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tetrabenazinehsa04724Glutamatergic synapse1.11E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Tetrabenazinehsa04725Cholinergic synapse9.51E-034P62873, P63218, P50151, Q16566GNB1, GNG5, GNG10, CAMK4More
Tetrabenazinehsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Tetrabenazinehsa04727GABAergic synapse2.45E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Tetrabenazinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Tetrabenazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Tetrabenazinehsa04744Phototransduction6.94E-032P62873, P0DP23GNB1, CALM1More
Tetrabenazinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Tetrabenazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tetrabenazinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Tetrabenazinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tetrabenazinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Tetrabenazinehsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Tetrabenazinehsa05034Alcoholism4.45E-0511O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tetrabenazinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Tetrabenazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tetrabenazinehsa05163Human cytomegalovirus infection2.00E-026P62873, P63218, P50151, P0DP23, P30101, P01568GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21More
Tetrabenazinehsa05167Kaposi sarcoma-associated herpesvirus infection2.00E-026P01568, P62873, P63218, P50151, P07948, P0DP23IFNA21, GNB1, GNG5, GNG10, LYN, CALM1More
Tetrabenazinehsa05168Herpes simplex virus 1 infection4.43E-028P01568, Q07955, P84103, Q13243, Q13489, P30101, Q13398, Q9NZL3IFNA21, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF224More
Tetrabenazinehsa05170Human immunodeficiency virus 1 infection1.83E-027P62873, P63218, P50151, P0DP23, P30101, P01568, P23528GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, CFL1More
Tetrabenazinehsa05200Pathways in cancer3.99E-0415Q13751, P08238, P43246, P84022, Q13485, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P01042LAMB3, HSP90AB1, MSH2, SMAD3, SMAD4, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, KNG1More
Tetrabenazinehsa05203Viral carcinogenesis3.28E-033Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Tetrabenazinehsa05204Chemical carcinogenesis2.96E-042P78417, P11712GSTO1, CYP2C9More
Tetrabenazinehsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Tetrabenazinehsa05212Pancreatic cancer3.28E-023P84022, Q13485, O75293SMAD3, SMAD4, GADD45BMore
Tetrabenazinehsa05214Glioma3.28E-023P0DP23, Q16566, O75293CALM1, CAMK4, GADD45BMore
Tetrabenazinehsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Tetrabenazinehsa05225Hepatocellular carcinoma4.54E-023Q92922, P78417, Q9NPI1SMARCC1, GSTO1, BRD7More
Tetrabenazinehsa05322Systemic lupus erythematosus1.73E-055P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tetrabenazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tetrabenazinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Tetrabenazinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Tetrabenazine (SDC: 3.53)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q9NPI1BRD7BromodomainNonecontaining protein 7Predicted00.03190.02750.12130.1923
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)