PharmaCoNets of Propiverine (SPCN: 100.64 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Propiverinehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Propiverinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Propiverinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Propiverinehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Propiverinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Propiverinehsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Propiverinehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Propiverinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Propiverinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Propiverinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Propiverinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Propiverinehsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Propiverinehsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Propiverinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Propiverinehsa00730Thiamine metabolism1.29E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Propiverinehsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Propiverinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Propiverinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Propiverinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Propiverinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Propiverinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Propiverinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Propiverinehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Propiverinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Propiverinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Propiverinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Propiverinehsa03013RNA transport2.98E-0613O14980, P52298, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF4A2, EIF4B, TACC3More
Propiverinehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Propiverinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Propiverinehsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Propiverinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Propiverinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Propiverinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Propiverinehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Propiverinehsa04071Sphingolipid signaling pathway2.17E-069P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Propiverinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Propiverinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Propiverinehsa04114Oocyte meiosis2.05E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Propiverinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Propiverinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Propiverinehsa04145Phagosome1.81E-027O75015, Q15080, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Propiverinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Propiverinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Propiverinehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Propiverinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Propiverinehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Propiverinehsa04340Hedgehog signaling pathway4.15E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Propiverinehsa04370VEGF signaling pathway1.29E-023P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Propiverinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Propiverinehsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Propiverinehsa04612Antigen processing and presentation2.31E-049P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Propiverinehsa04613Neutrophil extracellular trap formation3.01E-0519P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Propiverinehsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Propiverinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Propiverinehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Propiverinehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Propiverinehsa04657IL-17 signaling pathway5.01E-048O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Propiverinehsa04658Th1 and Th2 cell differentiation1.54E-0513Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Propiverinehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Propiverinehsa04660T cell receptor signaling pathway5.05E-0515P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Propiverinehsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Propiverinehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Propiverinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Propiverinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Propiverinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Propiverinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Propiverinehsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Propiverinehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Propiverinehsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Propiverinehsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Propiverinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Propiverinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Propiverinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Propiverinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Propiverinehsa04912GnRH signaling pathway3.14E-035P17252, Q16539, Q9Y6R4, Q14643, P22694PRKCA, MAPK14, MAP3K4, ITPR1, PRKACBMore
Propiverinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Propiverinehsa04914Progesterone-mediated oocyte maturation2.66E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Propiverinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Propiverinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Propiverinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Propiverinehsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Propiverinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Propiverinehsa04928Parathyroid hormone synthesis, secretion and action3.75E-025Q14643, P22694, P23771, P17252, P10415ITPR1, PRKACB, GATA3, PRKCA, BCL2More
Propiverinehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Propiverinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Propiverinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Propiverinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Propiverinehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Propiverinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Propiverinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Propiverinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Propiverinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Propiverinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Propiverinehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Propiverinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Propiverinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Propiverinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Propiverinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Propiverinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Propiverinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Propiverinehsa05133Pertussis4.24E-031P0C0L4C4AMore
Propiverinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Propiverinehsa05140Leishmaniasis9.39E-0411P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4More
Propiverinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Propiverinehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Propiverinehsa05146Amoebiasis7.00E-0613P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Propiverinehsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Propiverinehsa05152Tuberculosis1.26E-028Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14More
Propiverinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Propiverinehsa05168Herpes simplex virus 1 infection6.00E-0416P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212More
Propiverinehsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Propiverinehsa05202Transcriptional misregulation in cancer3.44E-0418Q12778, Q15532, P41732, P14780, P27930, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Propiverinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Propiverinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Propiverinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Propiverinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Propiverinehsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Propiverinehsa05321Inflammatory bowel disease2.39E-056O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Propiverinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Propiverinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Propiverinehsa05332Graft-versus-host disease5.06E-066P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Propiverinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Propiverinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Propiverine (SDC: 6.73)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)