PharmaCoNets of Misoprostol (SPCN: 5.78 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Misoprostolhsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Misoprostolhsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Misoprostolhsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Misoprostolhsa00630Glyoxylate and dicarboxylate metabolism2.78E-032P40925, P15104MDH1, GLULMore
Misoprostolhsa01100Metabolic pathways4.12E-0212P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3More
Misoprostolhsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Misoprostolhsa04012ErbB signaling pathway9.49E-033Q92529, P19174, P42338SHC3, PLCG1, PIK3CBMore
Misoprostolhsa04014Ras signaling pathway2.29E-047P42338, Q92529, Q9NRA1, P49767, P63218, P50151, P19174PIK3CB, SHC3, PDGFC, VEGFC, GNG5, GNG10, PLCG1More
Misoprostolhsa04015Rap1 signaling pathway3.91E-024Q9NRA1, P49767, P42338, P19174PDGFC, VEGFC, PIK3CB, PLCG1More
Misoprostolhsa04020Calcium signaling pathway2.16E-024P27987, P19174, Q9NRA1, P49767ITPKB, PLCG1, PDGFC, VEGFCMore
Misoprostolhsa04062Chemokine signaling pathway4.35E-036P07948, P42338, P19174, Q92529, P63218, P50151LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10More
Misoprostolhsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Misoprostolhsa04072Phospholipase D signaling pathway1.85E-046P42338, Q92529, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFCMore
Misoprostolhsa04151PI3K-Akt signaling pathway2.55E-038P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RBMore
Misoprostolhsa04370VEGF signaling pathway1.56E-022P19174, P42338PLCG1, PIK3CBMore
Misoprostolhsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Misoprostolhsa04510Focal adhesion1.55E-025P42338, O15335, Q9NRA1, P49767, Q92529PIK3CB, CHAD, PDGFC, VEGFC, SHC3More
Misoprostolhsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Misoprostolhsa04658Th1 and Th2 cell differentiation1.01E-024P07766, P19174, P14784, Q13761CD3E, PLCG1, IL2RB, RUNX3More
Misoprostolhsa04659Th17 cell differentiation2.16E-024P19174, P14784, P08238, P07766PLCG1, IL2RB, HSP90AB1, CD3EMore
Misoprostolhsa04662B cell receptor signaling pathway2.78E-023P42338, P07948, Q8N149PIK3CB, LYN, LILRA2More
Misoprostolhsa04664Fc epsilon RI signaling pathway7.30E-044P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Misoprostolhsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Misoprostolhsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Misoprostolhsa04724Glutamatergic synapse1.73E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Misoprostolhsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Misoprostolhsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Misoprostolhsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Misoprostolhsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Misoprostolhsa04910Insulin signaling pathway4.11E-023Q92529, Q13370, P42338SHC3, PDE3B, PIK3CBMore
Misoprostolhsa04914Progesterone-mediated oocyte maturation2.22E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Misoprostolhsa04915Estrogen signaling pathway4.76E-034P42338, Q92529, P08238, P11142PIK3CB, SHC3, HSP90AB1, HSPA8More
Misoprostolhsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Misoprostolhsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Misoprostolhsa04933AGE-RAGE signaling pathway in diabetic complications4.11E-023P42338, P49767, P19174PIK3CB, VEGFC, PLCG1More
Misoprostolhsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Misoprostolhsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Misoprostolhsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Misoprostolhsa05162Measles3.91E-024P14784, P07766, P42338, P11142IL2RB, CD3E, PIK3CB, HSPA8More
Misoprostolhsa05163Human cytomegalovirus infection1.14E-025P42338, P63218, P50151, Q14344, P30101PIK3CB, GNG5, GNG10, GNA13, PDIA3More
Misoprostolhsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-025P42338, P63218, P50151, P19174, P07948PIK3CB, GNG5, GNG10, PLCG1, LYNMore
Misoprostolhsa05169Epstein-Barr virus infection3.34E-025P42338, P07948, P30101, Q13761, P07766PIK3CB, LYN, PDIA3, RUNX3, CD3EMore
Misoprostolhsa05170Human immunodeficiency virus 1 infection7.03E-036P42338, P63218, P50151, P30101, P19174, P07766PIK3CB, GNG5, GNG10, PDIA3, PLCG1, CD3EMore
Misoprostolhsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Misoprostolhsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Misoprostolhsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Misoprostolhsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Misoprostolhsa05231Choline metabolism in cancer1.17E-034P42338, Q9NRA1, P19174, P23743PIK3CB, PDGFC, PLCG1, DGKAMore

Community members of Misoprostol (SDC: 0.90)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)