PharmaCoNets of Liothyronine (SPCN: 6.88 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Liothyroninehsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Liothyroninehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Liothyroninehsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Liothyroninehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Liothyroninehsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Liothyroninehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Liothyroninehsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Liothyroninehsa04020Calcium signaling pathway5.81E-047Q96DU7, Q13557, P21860, P05141, P12236, P26678, P63092ITPKC, CAMK2D, ERBB3, SLC25A5, SLC25A6, PLN, GNASMore
Liothyroninehsa04022cGMP-PKG signaling pathway9.36E-036P61586, P26678, Q99941, P18848, P05141, P12236RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6More
Liothyroninehsa04151PI3K-Akt signaling pathway1.36E-029P21860, P27348, O14944, P07900, Q15831, P22105, Q99941, P18848, O95988ERBB3, YWHAQ, EREG, HSP90AA1, STK11, TNXB, CREBL1, ATF4, TCL1BMore
Liothyroninehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Liothyroninehsa04261Adrenergic signaling in cardiomyocytes3.12E-025P63092, Q99941, P18848, P26678, Q13557GNAS, CREBL1, ATF4, PLN, CAMK2DMore
Liothyroninehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Liothyroninehsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Liothyroninehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Liothyroninehsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Liothyroninehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Liothyroninehsa04925Aldosterone synthesis and secretion1.68E-024Q99941, P18848, P63092, Q13557CREBL1, ATF4, GNAS, CAMK2DMore
Liothyroninehsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Liothyroninehsa04928Parathyroid hormone synthesis, secretion and action2.33E-024P63092, P61586, Q99941, P18848GNAS, RHOA, CREBL1, ATF4More
Liothyroninehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Liothyroninehsa04934Cushing syndrome1.37E-035Q99941, P18848, P63092, O15169, Q13557CREBL1, ATF4, GNAS, AXIN1, CAMK2DMore
Liothyroninehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Liothyroninehsa05010Alzheimer disease1.36E-029Q92542, O15239, P05496, P18848, O15169, P05141, P12236, P43686, P62195NCSTN, NDUFA1, ATP5G1, ATF4, AXIN1, SLC25A5, SLC25A6, PSMC4, PSMC5More
Liothyroninehsa05012Parkinson disease2.88E-039O15239, P05496, P05141, P12236, P63092, P18848, P43686, P62195, Q13557NDUFA1, ATP5G1, SLC25A5, SLC25A6, GNAS, ATF4, PSMC4, PSMC5, CAMK2DMore
Liothyroninehsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Liothyroninehsa05020Prion disease1.15E-029P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1More
Liothyroninehsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Liothyroninehsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Liothyroninehsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Liothyroninehsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Liothyroninehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Liothyroninehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Liothyroninehsa05203Viral carcinogenesis7.09E-036Q99941, P18848, P27348, Q15283, P61586, P61978CREBL1, ATF4, YWHAQ, RASA2, RHOA, HNRPKMore
Liothyroninehsa05206MicroRNAs in cancer1.54E-026P21860, P61978, P46531, P63279, P22105, P61586ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOAMore
Liothyroninehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Liothyroninehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Liothyroninehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Liothyroninehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Liothyroninehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Liothyroninehsa05415Diabetic cardiomyopathy1.92E-026P05141, P12236, O15239, P05496, Q13557, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, PLNMore

Community members of Liothyronine (SDC: 1.43)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)