| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Glyburide | hsa00030 | Pentose phosphate pathway | 1.69E-02 | 2 | P60891, P37837 | PRPS1, TALDO1 | More | | | Glyburide | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Glyburide | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Glyburide | hsa00071 | Fatty acid degradation | 2.32E-03 | 4 | O75521, P00325, P11766, P33121 | ECI2, ADH1B, ADH5, ACSL1 | More | | | Glyburide | hsa00270 | Cysteine and methionine metabolism | 4.56E-02 | 3 | Q99707, P26358, Q9UHY7 | MTR, DNMT1, ENOPH1 | More | | | Glyburide | hsa00500 | Starch and sucrose metabolism | 7.82E-06 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Glyburide | hsa00520 | Amino sugar and nucleotide sugar metabolism | 2.24E-02 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | | Glyburide | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Glyburide | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Glyburide | hsa00591 | Linoleic acid metabolism | 8.00E-04 | 1 | P11712 | CYP2C9 | More | | | Glyburide | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.57E-05 | 3 | P40925, P40926, P15104 | MDH1, MDH2, GLUL | More | | | Glyburide | hsa00730 | Thiamine metabolism | 1.50E-06 | 3 | Q9Y6K8, P05186, P24666 | AK5, ALPL, ACP1 | More | | | Glyburide | hsa00760 | Nicotinate and nicotinamide metabolism | 3.52E-02 | 1 | P21589 | NT5E | More | | | Glyburide | hsa00770 | Pantothenate and CoA biosynthesis | 2.27E-02 | 2 | O95498, O95497 | VNN2, VNN1 | More | | | Glyburide | hsa00830 | Retinol metabolism | 2.20E-02 | 4 | P00325, P11766, Q9BPW9, O75911 | ADH1B, ADH5, DHRS9, DHRS3 | More | | | Glyburide | hsa00860 | Porphyrin and chlorophyll metabolism | 1.69E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Glyburide | hsa00920 | Sulfur metabolism | 1.65E-02 | 1 | Q16762 | TST | More | | | Glyburide | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.77E-04 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Glyburide | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Glyburide | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Glyburide | hsa00983 | Drug metabolism - other enzymes | 2.54E-03 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Glyburide | hsa01100 | Metabolic pathways | 3.52E-02 | 23 | P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737 | ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGL | More | | | Glyburide | hsa01230 | Biosynthesis of amino acids | 3.59E-02 | 3 | P60891, Q99707, P37837 | PRPS1, MTR, TALDO1 | More | | | Glyburide | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa01522 | Endocrine resistance | 4.47E-03 | 6 | P14780, P22694, P04049, Q9UM47, P10415, Q13323 | MMP9, PRKACB, RAF1, NOTCH3, BCL2, BIK | More | | | Glyburide | hsa02010 | ABC transporters | 1.68E-03 | 1 | Q8IZY2 | ABCA7 | More | | | Glyburide | hsa03008 | Ribosome biogenesis in eukaryotes | 6.93E-04 | 6 | Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0 | UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2B | More | | | Glyburide | hsa03013 | RNA transport | 1.84E-07 | 19 | O14980, P52298, Q09161, O14893, P61326, P38919, Q9GZY0, P37198, Q7Z3B4, P35658, P47813, Q14152, P55884, O75822, P78345, Q14240, P23588, Q9Y6A5, Q53GS7 | XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NXF2; NXF2B, NUP62, NUP54, NUP214, EIF1AX, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, GLE1 | More | | | Glyburide | hsa03015 | mRNA surveillance pathway | 9.78E-03 | 6 | O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7 | RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1 | More | | | Glyburide | hsa03020 | RNA polymerase | 1.81E-02 | 1 | P24928 | POLR2A | More | | | Glyburide | hsa03022 | Basal transcription factors | 1.91E-02 | 3 | P20226, O00268, Q15544 | TBP, TAF4, TAF11 | More | | | Glyburide | hsa03040 | Spliceosome | 1.54E-05 | 13 | Q14562, O43143, O60508, P17844, P08579, P51991, P61978, Q07955, Q01130, Q13243, P11142, O43447, O75643 | DHX8, DHX15, CDC40, DDX5, SNRPB2, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1 | More | | | Glyburide | hsa03060 | Protein export | 1.90E-02 | 2 | Q15070, O76094 | OXA1L, SRP72 | More | | | Glyburide | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04012 | ErbB signaling pathway | 2.31E-03 | 6 | Q13153, P16333, P19174, P42338, P01106, P04049 | PAK1, NCK1, PLCG1, PIK3CB, MYC, RAF1 | More | | | Glyburide | hsa04014 | Ras signaling pathway | 1.72E-04 | 11 | P04049, P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174 | RAF1, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Glyburide | hsa04015 | Rap1 signaling pathway | 1.42E-03 | 9 | P04049, P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174 | RAF1, EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1 | More | | | Glyburide | hsa04020 | Calcium signaling pathway | 2.61E-02 | 6 | P27987, P21796, P19174, P0DP23, Q9NRA1, P49767 | ITPKB, VDAC1, PLCG1, CALM1, PDGFC, VEGFC | More | | | Glyburide | hsa04022 | cGMP-PKG signaling pathway | 3.15E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04024 | cAMP signaling pathway | 1.73E-03 | 2 | P04049, Q13153 | RAF1, PAK1 | More | | | Glyburide | hsa04060 | Cytokine-cytokine receptor interaction | 4.71E-02 | 2 | P78552, O75509 | IL13RA1, TNFRSF21 | More | | | Glyburide | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.48E-02 | 5 | P09341, P19875, P25024, P25025, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, IL2RB | More | | | Glyburide | hsa04062 | Chemokine signaling pathway | 1.35E-05 | 16 | P25024, P25025, P09341, P19875, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P04049, P25963 | CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, RAF1, NFKBIA | More | | | Glyburide | hsa04064 | NF-kappa B signaling pathway | 2.52E-06 | 19 | P10415, Q13489, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643, Q9NQC7 | BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTB, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.766 | | P22894 | MMP8 | Neutrophil collagenase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.959 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.744 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.924 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | | P22894 | MMP8 | Neutrophil collagenase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.867 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P22894 | MMP8 | Neutrophil collagenase | Q04759 | PRKCQ | Protein kinase C theta type | -0.756 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P22894 | MMP8 | Neutrophil collagenase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.891 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.783 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.967 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q8WV28 | BLNK | B-cell linker protein | -0.706 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.822 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09341 | CXCL1 | Growth-regulated alpha protein | 0.74 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 |
| | Glyburide | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04070 | Phosphatidylinositol signaling system | 1.12E-02 | 5 | P19174, P0DP23, P42338, P23743, P27987 | PLCG1, CALM1, PIK3CB, DGKA, ITPKB | More | | | Glyburide | hsa04071 | Sphingolipid signaling pathway | 5.05E-07 | 12 | P04049, P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2 | RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P17252 | PRKCA | Protein kinase C alpha type | 0.807 | | P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | | P22894 | MMP8 | Neutrophil collagenase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.721 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.841 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P22894 | MMP8 | Neutrophil collagenase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.787 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | 0.787 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | P22894 | MMP8 | Neutrophil collagenase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.834 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q16537 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | 0.718 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.781 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.884 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | P22894 | MMP8 | Neutrophil collagenase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.879 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P04637 | TP53 | Cellular tumor antigen p53 | 0.753 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.766 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.859 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.959 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.822 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | -0.866 |
| | Glyburide | hsa04072 | Phospholipase D signaling pathway | 4.15E-04 | 10 | P04049, P42338, Q92529, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1 | RAF1, PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC | More | | | Glyburide | hsa04080 | Neuroactive ligand-receptor interaction | 1.07E-04 | 10 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADM | More | | | Glyburide | hsa04114 | Oocyte meiosis | 1.33E-02 | 4 | P51812, Q02750, P16298, Q17RY0 | RPS6KA3, MAP2K1, PPP3CB, CPEB4 | More | | | Glyburide | hsa04122 | Sulfur relay system | 1.65E-02 | 1 | Q16762 | TST | More | | | Glyburide | hsa04136 | Autophagy - other | 5.92E-03 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Glyburide | hsa04140 | Autophagy - animal | 9.16E-03 | 6 | P04049, P22694, Q14643, P10415, Q9H1Y0, Q04759 | RAF1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Glyburide | hsa04141 | Protein processing in endoplasmic reticulum | 1.91E-03 | 6 | P18848, Q15437, Q99941, P11142, P07900, Q9NR31 | ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A | More | | | Glyburide | hsa04142 | Lysosome | 2.98E-02 | 2 | P10619, P49281 | CTSA, SLC11A2 | More | | | Glyburide | hsa04145 | Phagosome | 1.61E-05 | 10 | O75015, P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765 | FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOB | More | | | Glyburide | hsa04150 | mTOR signaling pathway | 9.03E-04 | 7 | P42338, P04049, Q02750, Q9NQL2, P51812, Q13322, P49841 | PIK3CB, RAF1, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3B | More | | | Glyburide | hsa04151 | PI3K-Akt signaling pathway | 1.17E-04 | 19 | P62753, P42338, P01106, P27348, P20827, Q9NRA1, P49767, P07900, P08238, P62873, P63218, P50151, O15335, P22105, P14784, P01568, Q99941, P18848, O00141 | RPS6, PIK3CB, MYC, YWHAQ, EFNA1, PDGFC, VEGFC, HSP90AA1, HSP90AB1, GNB1, GNG5, GNG10, CHAD, TNXB, IL2RB, IFNA21, CREBL1, ATF4, SGK | More | | | Glyburide | hsa04210 | Apoptosis | 3.64E-03 | 5 | O76075, P01375, Q9NR28, Q16548, P04049 | DFFB, TNF, DIABLO, BCL2A1, RAF1 | More | | | Glyburide | hsa04211 | Longevity regulating pathway | 2.72E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | | Glyburide | hsa04213 | Longevity regulating pathway - multiple species | 3.85E-02 | 4 | P42338, Q9Y4H2, P11142, Q13547 | PIK3CB, IRS2, HSPA8, HDAC1 | More | | | Glyburide | hsa04218 | Cellular senescence | 2.49E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.46E-02 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Glyburide | hsa04270 | Vascular smooth muscle contraction | 2.32E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04330 | Notch signaling pathway | 2.77E-02 | 2 | Q92542, P49768 | NCSTN, PSEN1 | More | | | Glyburide | hsa04340 | Hedgehog signaling pathway | 5.89E-06 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Glyburide | hsa04360 | Axon guidance | 1.36E-02 | 6 | P16333, P20827, O95631, P42338, P04049, P19174 | NCK1, EFNA1, NTN1, PIK3CB, RAF1, PLCG1 | More | | | Glyburide | hsa04370 | VEGF signaling pathway | 1.79E-04 | 4 | P16298, Q05397, Q02750, P04049 | PPP3CB, PTK2, MAP2K1, RAF1 | More | | | Glyburide | hsa04371 | Apelin signaling pathway | 1.18E-03 | 8 | P62873, P63218, P50151, P04049, Q13370, Q14814, Q14344, P0DP23 | GNB1, GNG5, GNG10, RAF1, PDE3B, MEF2D, GNA13, CALM1 | More | | | Glyburide | hsa04380 | Osteoclast differentiation | 4.45E-04 | 14 | Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324 | CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA | More | | | Glyburide | hsa04392 | Hippo signaling pathway - multiple species | 1.51E-02 | 1 | Q13153 | PAK1 | More | | | Glyburide | hsa04510 | Focal adhesion | 3.48E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Glyburide | hsa04540 | Gap junction | 7.37E-04 | 6 | P17252, P22694, Q13509, P68371, P04049, Q14643 | PRKCA, PRKACB, TUBB3, TUBB2C, RAF1, ITPR1 | More | | | Glyburide | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04610 | Complement and coagulation cascades | 2.57E-08 | 2 | P00734, P0C0L4 | F2, C4A | More | | | Glyburide | hsa04612 | Antigen processing and presentation | 2.40E-02 | 8 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Glyburide | hsa04613 | Neutrophil extracellular trap formation | 4.80E-10 | 30 | P42338, P19174, P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, P63261, O43315, Q16539 | PIK3CB, PLCG1, PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P17252 | PRKCA | Protein kinase C alpha type | 0.807 | | P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11215 | ITGAM | Integrin alpha-M | -0.877 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O60603 | TLR2 | Toll-like receptor 2 | 0.836 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | O60603 | TLR2 | Toll-like receptor 2 | -0.797 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P05164 | MPO | Myeloperoxidase | 0.858 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P05164 | MPO | Myeloperoxidase | -0.754 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08246 | ELA2 | Neutrophil elastase | 0.817 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P08246 | ELA2 | Neutrophil elastase | -0.833 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | -0.771 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P22894 | MMP8 | Neutrophil collagenase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.877 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0C0S5 | H2AFZ | Histone H2A.Z | 0.785 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.859 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P22894 | MMP8 | Neutrophil collagenase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.909 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | -0.703 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | -0.703 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q93079 | H2BC9 | Histone H2B type 1-H | 0.756 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | 0.72 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.708 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.755 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.836 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.89 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20160 | AZU1 | Azurocidin | 0.781 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P22894 | MMP8 | Neutrophil collagenase | P20160 | AZU1 | Azurocidin | 0.824 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08311 | CTSG | Cathepsin G | 0.829 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P22894 | MMP8 | Neutrophil collagenase | P08311 | CTSG | Cathepsin G | 0.8 | | P22894 | MMP8 | Neutrophil collagenase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.7 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.852 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.888 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.983 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P22894 | MMP8 | Neutrophil collagenase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.756 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.833 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.723 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.839 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P22894 | MMP8 | Neutrophil collagenase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.88 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P63261 | ACTG1 | Actin, cytoplasmic 2 | 0.719 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O43315 | AQP9 | Aquaporin-9 | 0.897 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O43315 | AQP9 | Aquaporin-9 | 0.934 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 |
| | Glyburide | hsa04614 | Renin-angiotensin system | 2.74E-02 | 3 | P15144, P08311, O75787 | ANPEP, CTSG, ATP6AP2 | More | | | Glyburide | hsa04620 | Toll-like receptor signaling pathway | 4.00E-02 | 4 | P01568, P42224, P25963, P42338 | IFNA21, STAT1, NFKBIA, PIK3CB | More | | | Glyburide | hsa04621 | NOD-like receptor signaling pathway | 1.30E-05 | 14 | Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838 | MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.868 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.804 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.81 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P10599 | TXN | Thioredoxin | 0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10599 | TXN | Thioredoxin | 0.713 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P10599 | TXN | Thioredoxin | 0.856 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9H1Y0 | ATG5 | Autophagy protein 5 | -0.73 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H1Y0 | ATG5 | Autophagy protein 5 | -0.895 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | Q9H1Y0 | ATG5 | Autophagy protein 5 | -0.748 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.912 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.94 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.899 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.924 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.917 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.769 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.766 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.73 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P01375 | TNF | Tumor necrosis factor | 0.701 | | Q9NP78 | ABCB9 | ABC-type oligopeptide transporter ABCB9 | P01375 | TNF | Tumor necrosis factor | 0.828 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09341 | CXCL1 | Growth-regulated alpha protein | 0.74 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.771 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.706 | | Q9NP78 | ABCB9 | ABC-type oligopeptide transporter ABCB9 | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.79 | | Q9NP78 | ABCB9 | ABC-type oligopeptide transporter ABCB9 | P59665 | DEFA1; DEFA1B | Neutrophil defensin 1 | 0.724 | | Q9NP78 | ABCB9 | ABC-type oligopeptide transporter ABCB9 | P59666 | DEFA3 | Neutrophil defensin 3 | 0.724 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P12838 | DEFA4 | Neutrophil defensin 4 | 0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.712 | | Q9NP78 | ABCB9 | ABC-type oligopeptide transporter ABCB9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.841 |
| | Glyburide | hsa04623 | Cytosolic DNA-sensing pathway | 3.67E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Glyburide | hsa04625 | C-type lectin receptor signaling pathway | 3.69E-05 | 15 | Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P42224, P20749, P25963, Q14643, P01375, Q13191, P42338, P0DP24, P0DP23, Q16539 | CLEC4E, RAF1, PAK1, IL1B, CYLD, STAT1, BCL3, NFKBIA, ITPR1, TNF, CBLB, PIK3CB, CALM2, CALM1, MAPK14 | More | | | Glyburide | hsa04630 | JAK-STAT signaling pathway | 1.49E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04640 | Hematopoietic cell lineage | 2.62E-03 | 14 | P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584 | ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1B | More | | | Glyburide | hsa04650 | Natural killer cell mediated cytotoxicity | 1.26E-07 | 18 | P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, P26715 | PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | | Glyburide | hsa04657 | IL-17 signaling pathway | 6.55E-07 | 8 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.924 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.917 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.769 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.868 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.815 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.82 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.725 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09341 | CXCL1 | Growth-regulated alpha protein | 0.74 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.771 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.706 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.917 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.827 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.775 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.706 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.715 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.888 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P01375 | TNF | Tumor necrosis factor | 0.701 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 |
| | Glyburide | hsa04658 | Th1 and Th2 cell differentiation | 1.09E-11 | 17 | P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761 | NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.736 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P42226 | STAT6 | Signal transducer and activator of transcription 6 | 0.852 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.753 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P13612 | ITGA4 | Integrin alpha-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.764 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.738 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P13612 | ITGA4 | Integrin alpha-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.822 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.845 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.804 | | P13612 | ITGA4 | Integrin alpha-4 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.78 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| | Glyburide | hsa04659 | Th17 cell differentiation | 2.13E-07 | 18 | P25963, Q04759, Q16539, P19174, P06239, P42224, P42226, P14784, P13765, P14778, Q9UL17, P23771, P01584, P08238, P07766, P09693, P20963, P23458 | NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P78508 | KCNJ10 | ATP-sensitive inward rectifier potassium channel 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.753 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P42226 | STAT6 | Signal transducer and activator of transcription 6 | 0.852 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P78508 | KCNJ10 | ATP-sensitive inward rectifier potassium channel 10 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.829 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.845 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P78508 | KCNJ10 | ATP-sensitive inward rectifier potassium channel 10 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.877 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.738 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.753 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P78508 | KCNJ10 | ATP-sensitive inward rectifier potassium channel 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.819 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 |
| | Glyburide | hsa04660 | T cell receptor signaling pathway | 5.41E-11 | 17 | P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841 | TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.73 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P13612 | ITGA4 | Integrin alpha-4 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.834 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.8 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P13612 | ITGA4 | Integrin alpha-4 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | 1 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.72 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P13612 | ITGA4 | Integrin alpha-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P13612 | ITGA4 | Integrin alpha-4 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.83 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.815 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 |
| | Glyburide | hsa04662 | B cell receptor signaling pathway | 2.02E-05 | 7 | P25963, P49841, P42338, P07948, P21854, Q8N149, P04049 | NFKBIA, GSK3B, PIK3CB, LYN, CD72, LILRA2, RAF1 | More | | | Glyburide | hsa04664 | Fc epsilon RI signaling pathway | 2.78E-03 | 5 | P42338, P07948, P19174, P04049, P09917 | PIK3CB, LYN, PLCG1, RAF1, ALOX5 | More | | | Glyburide | hsa04666 | Fc gamma R-mediated phagocytosis | 1.33E-04 | 11 | O75015, P07948, P42338, P19174, P04049, P23528, P49006, P06396, O14494, P14598, P17252 | FCGR3B, LYN, PIK3CB, PLCG1, RAF1, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCA | More | | | Glyburide | hsa04713 | Circadian entrainment | 4.00E-02 | 4 | P0DP23, P62873, P63218, P50151 | CALM1, GNB1, GNG5, GNG10 | More | | | Glyburide | hsa04714 | Thermogenesis | 3.31E-02 | 4 | P51828, P62753, P12074, O15239 | ADCY7, RPS6, COX6A1, NDUFA1 | More | | | Glyburide | hsa04720 | Long-term potentiation | 2.17E-03 | 4 | P16298, P51812, Q02750, P04049 | PPP3CB, RPS6KA3, MAP2K1, RAF1 | More | | | Glyburide | hsa04722 | Neurotrophin signaling pathway | 2.32E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04724 | Glutamatergic synapse | 2.92E-02 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Glyburide | hsa04725 | Cholinergic synapse | 2.35E-04 | 10 | P51828, P22694, Q14643, P62873, P63218, P50151, P18848, Q13557, P42338, P10415 | ADCY7, PRKACB, ITPR1, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, BCL2 | More | | | Glyburide | hsa04726 | Serotonergic synapse | 1.33E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04727 | GABAergic synapse | 8.14E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Glyburide | hsa04728 | Dopaminergic synapse | 4.78E-02 | 3 | Q99941, P18848, Q13557 | CREBL1, ATF4, CAMK2D | More | | | Glyburide | hsa04730 | Long-term depression | 1.55E-03 | 2 | Q14344, P04049 | GNA13, RAF1 | More | | | Glyburide | hsa04744 | Phototransduction | 1.32E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Glyburide | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.44E-06 | 12 | P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23 | IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1 | More | | | Glyburide | hsa04810 | Regulation of actin cytoskeleton | 2.25E-02 | 7 | P12814, Q13009, P04049, P42338, P11215, Q14344, Q9NRA1 | ACTN1, TIAM1, RAF1, PIK3CB, ITGAM, GNA13, PDGFC | More | | | Glyburide | hsa04910 | Insulin signaling pathway | 2.51E-03 | 4 | P22694, P06737, P04049, P49841 | PRKACB, PYGL, RAF1, GSK3B | More | | | Glyburide | hsa04911 | Insulin secretion | 4.03E-04 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Glyburide | hsa04912 | GnRH signaling pathway | 3.22E-03 | 9 | P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049 | ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1 | More | | | Glyburide | hsa04913 | Ovarian steroidogenesis | 2.72E-02 | 2 | P42330, P22694 | AKR1C3, PRKACB | More | | | Glyburide | hsa04914 | Progesterone-mediated oocyte maturation | 1.85E-03 | 8 | Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750, P04049 | CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1 | More | | | Glyburide | hsa04915 | Estrogen signaling pathway | 4.99E-04 | 6 | P04049, Q99941, P18848, P51828, P07900, P11142 | RAF1, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8 | More | | | Glyburide | hsa04916 | Melanogenesis | 1.33E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04917 | Prolactin signaling pathway | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04918 | Thyroid hormone synthesis | 1.69E-03 | 4 | P51828, Q99941, P18848, P02768 | ADCY7, CREBL1, ATF4, ALB | More | | | Glyburide | hsa04919 | Thyroid hormone signaling pathway | 6.83E-04 | 5 | P49841, P04049, P22694, O60244, Q9NVC6 | GSK3B, RAF1, PRKACB, MED14, MED17 | More | | | Glyburide | hsa04921 | Oxytocin signaling pathway | 2.32E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Glyburide | hsa04924 | Renin secretion | 3.09E-03 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Glyburide | hsa04925 | Aldosterone synthesis and secretion | 1.69E-03 | 4 | Q99941, P18848, P51828, Q13557 | CREBL1, ATF4, ADCY7, CAMK2D | More | | | Glyburide | hsa04926 | Relaxin signaling pathway | 2.92E-04 | 10 | P25963, P42338, P62873, P63218, P50151, Q99941, P18848, P49767, P51828, P04049 | NFKBIA, PIK3CB, GNB1, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, RAF1 | More | | | Glyburide | hsa04927 | Cortisol synthesis and secretion | 3.03E-04 | 5 | Q14643, Q99941, P18848, P51828, P22694 | ITPR1, CREBL1, ATF4, ADCY7, PRKACB | More | | | Glyburide | hsa04928 | Parathyroid hormone synthesis, secretion and action | 1.61E-04 | 8 | Q14643, P51828, P22694, P23771, P04049, Q99941, P18848, P10415 | ITPR1, ADCY7, PRKACB, GATA3, RAF1, CREBL1, ATF4, BCL2 | More | | | Glyburide | hsa04929 | GnRH secretion | 2.42E-03 | 3 | P42338, P49407, P04049 | PIK3CB, ARRB1, RAF1 | More | | | Glyburide | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Glyburide | hsa04934 | Cushing syndrome | 2.44E-04 | 7 | Q14643, Q99941, P18848, P51828, P22694, Q13557, P04628 | ITPR1, CREBL1, ATF4, ADCY7, PRKACB, CAMK2D, WNT1 | More | | | Glyburide | hsa04935 | Growth hormone synthesis, secretion and action | 5.33E-03 | 4 | P51828, P04049, Q99941, P18848 | ADCY7, RAF1, CREBL1, ATF4 | More | | | Glyburide | hsa04940 | Type I diabetes mellitus | 4.18E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Glyburide | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.38E-02 | 1 | P48048 | KCNJ1 | More | | | Glyburide | hsa04964 | Proximal tubule bicarbonate reclamation | 1.68E-03 | 1 | P00918 | CA2 | More | | | Glyburide | hsa04966 | Collecting duct acid secretion | 1.68E-03 | 1 | P00918 | CA2 | More | | | Glyburide | hsa04970 | Salivary secretion | 2.11E-02 | 3 | P07550, P22694, Q14643 | ADRB2, PRKACB, ITPR1 | More | | | Glyburide | hsa04972 | Pancreatic secretion | 1.99E-02 | 3 | Q14643, P20020, P17252 | ITPR1, ATP2B1, PRKCA | More | | | Glyburide | hsa04973 | Carbohydrate digestion and absorption | 6.19E-05 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Glyburide | hsa04976 | Bile secretion | 2.44E-02 | 2 | P22694, P08183 | PRKACB, ABCB1 | More | | | Glyburide | hsa05012 | Parkinson disease | 4.01E-02 | 6 | P21796, P60604, P19174, P0DP23, Q71U36, Q13509 | VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3 | More | | | Glyburide | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | | Glyburide | hsa05031 | Amphetamine addiction | 6.41E-03 | 3 | Q13557, Q99941, P18848 | CAMK2D, CREBL1, ATF4 | More | | | Glyburide | hsa05032 | Morphine addiction | 7.60E-03 | 5 | P62873, P63218, P50151, Q13370, P43250 | GNB1, GNG5, GNG10, PDE3B, GRK6 | More | | | Glyburide | hsa05034 | Alcoholism | 1.35E-05 | 11 | Q13547, P0DP23, P62873, P63218, P50151, P04049, Q93077, P62807, Q93079, O60814, P68431 | HDAC1, CALM1, GNB1, GNG5, GNG10, RAF1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Glyburide | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.07E-05 | 7 | Q16539, Q13153, P09341, P19875, P19174, P25024, P25025 | MAPK14, PAK1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Glyburide | hsa05132 | Salmonella infection | 1.56E-03 | 17 | P25963, P08238, P04049, Q9UJU2, P01106, P63261, P42338, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, RAF1, LEF1, MYC, ACTG1, PIK3CB, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Glyburide | hsa05133 | Pertussis | 1.87E-04 | 2 | P0DP23, P0C0L4 | CALM1, C4A | More | | | Glyburide | hsa05134 | Legionellosis | 1.29E-02 | 4 | P11215, P11142, P09341, P19875 | ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Glyburide | hsa05140 | Leishmaniasis | 5.78E-07 | 12 | P13612, O75015, P14598, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13612 | ITGA4 | Integrin alpha-4 | -0.7 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P13612 | ITGA4 | Integrin alpha-4 | -0.77 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.901 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.708 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.75 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P22894 | MMP8 | Neutrophil collagenase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.797 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | O60603 | TLR2 | Toll-like receptor 2 | -0.797 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P01375 | TNF | Tumor necrosis factor | 0.701 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P49006 | MARCKSL1 | MARCKS-related protein | 0.706 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | P49006 | MARCKSL1 | MARCKS-related protein | -0.747 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q99712 | KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.868 | | P22894 | MMP8 | Neutrophil collagenase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.744 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.89 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 |
| | Glyburide | hsa05143 | African trypanosomiasis | 1.74E-03 | 2 | P69905, P68871 | HBA2, HBB | More | | | Glyburide | hsa05144 | Malaria | 3.81E-03 | 8 | P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718 | CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1 | More | | | Glyburide | hsa05146 | Amoebiasis | 5.22E-07 | 14 | P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311 | IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG | More | | | Glyburide | hsa05150 | Staphylococcus aureus infection | 1.82E-06 | 10 | P21730, P21462, O75015, P13765, Q16581, Q14532, P59665, P59666, P12838, P49913 | C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | | Glyburide | hsa05152 | Tuberculosis | 1.38E-02 | 10 | P04049, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617 | RAF1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1 | More | | | Glyburide | hsa05160 | Hepatitis C | 1.99E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05161 | Hepatitis B | 5.33E-03 | 4 | P04049, Q99941, P18848, P27348 | RAF1, CREBL1, ATF4, YWHAQ | More | | | Glyburide | hsa05162 | Measles | 1.84E-02 | 7 | P01568, P25963, P42224, P14784, P07766, P42338, P11142 | IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8 | More | | | Glyburide | hsa05163 | Human cytomegalovirus infection | 1.59E-04 | 17 | P42338, P04049, P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P01106, P14778, P25025, Q16539, O00463, P30101, P01568 | PIK3CB, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, MYC, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21 | More | | | Glyburide | hsa05164 | Influenza A | 3.65E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.26E-06 | 16 | P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, P04049, Q02750, P07948, P01106, P0DP23, P0CG47 | IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, RAF1, MAP2K1, LYN, MYC, CALM1, UBB | More | | | Glyburide | hsa05168 | Herpes simplex virus 1 infection | 4.57E-02 | 10 | P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189 | More | | | Glyburide | hsa05169 | Epstein-Barr virus infection | 3.41E-04 | 22 | P13765, P01106, Q13547, O00463, P25963, P16070, P10415, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, Q8WV28, P01568, P01375, O60603, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, CD44, BCL2, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, BLNK, IFNA21, TNF, TLR2, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.845 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.924 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P16070 | CD44 | CD44 antigen | 0.803 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.766 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.852 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.896 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.804 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.822 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.847 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q8WV28 | BLNK | B-cell linker protein | -0.706 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O60603 | TLR2 | Toll-like receptor 2 | 0.836 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 |
| | Glyburide | hsa05170 | Human immunodeficiency virus 1 infection | 1.33E-05 | 16 | P42338, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333 | PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1B | More | | | Glyburide | hsa05200 | Pathways in cancer | 1.82E-03 | 17 | P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784 | PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB | More | | | Glyburide | hsa05202 | Transcriptional misregulation in cancer | 6.33E-09 | 24 | Q12778, Q15532, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, Q15652, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522 | FOXO1, SS18, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q12778 | FOXO1 | Forkhead box protein O1 | 0.714 | | P22894 | MMP8 | Neutrophil collagenase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.72 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15532 | SS18 | Protein SSXT | -0.772 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q15532 | SS18 | Protein SSXT | 0.893 | | P22894 | MMP8 | Neutrophil collagenase | Q15532 | SS18 | Protein SSXT | -0.867 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P41732 | TSPAN7 | Tetraspanin-7 | -0.834 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.863 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.917 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.72 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P22894 | MMP8 | Neutrophil collagenase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.882 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.881 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P14923 | JUP | Junction plakoglobin | 0.914 | | P22894 | MMP8 | Neutrophil collagenase | P14923 | JUP | Junction plakoglobin | -0.809 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.967 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.71 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.783 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15652 | JMJD1C | Probable JmjC domain-containing histone demethylation protein 2C | 0.754 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O15550 | UTX | Lysine-specific demethylase 6A | 0.724 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | O15550 | UTX | Lysine-specific demethylase 6A | -0.808 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P04637 | TP53 | Cellular tumor antigen p53 | 0.753 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.73 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.73 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P05164 | MPO | Myeloperoxidase | 0.858 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P05164 | MPO | Myeloperoxidase | -0.754 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P12838 | DEFA4 | Neutrophil defensin 4 | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.784 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08246 | ELA2 | Neutrophil elastase | 0.817 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P08246 | ELA2 | Neutrophil elastase | -0.833 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.742 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.741 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.783 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | P22894 | MMP8 | Neutrophil collagenase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.778 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.847 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.919 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12980 | LYL1 | Protein lyl-1 | 0.784 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.822 | | Q13093 | PLA2G7 | Platelet-activating factor acetylhydrolase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.768 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 |
| | Glyburide | hsa05203 | Viral carcinogenesis | 2.83E-05 | 15 | Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P12814, P25963, P61978, P62807, Q93079, O60814 | CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9, H2BC12 | More | | | Glyburide | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Glyburide | hsa05205 | Proteoglycans in cancer | 1.08E-02 | 9 | Q14643, P63261, P04049, P04637, P14780, P17252, O60603, Q13635, P08962 | ITPR1, ACTG1, RAF1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63 | More | | | Glyburide | hsa05206 | MicroRNAs in cancer | 8.75E-03 | 8 | P30304, P09493, P01106, P42338, Q13547, P20827, P19174, P04049 | CDC25A, TPM1, MYC, PIK3CB, HDAC1, EFNA1, PLCG1, RAF1 | More | | | Glyburide | hsa05210 | Colorectal cancer | 1.66E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05211 | Renal cell carcinoma | 3.93E-04 | 2 | Q13153, P04049 | PAK1, RAF1 | More | | | Glyburide | hsa05212 | Pancreatic cancer | 1.16E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05213 | Endometrial cancer | 4.26E-03 | 3 | O15169, Q02750, P04049 | AXIN1, MAP2K1, RAF1 | More | | | Glyburide | hsa05214 | Glioma | 2.01E-03 | 5 | P0DP23, P04049, P42338, P19174, O75293 | CALM1, RAF1, PIK3CB, PLCG1, GADD45B | More | | | Glyburide | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05216 | Thyroid cancer | 3.59E-02 | 3 | Q9UJU2, P04637, P24522 | LEF1, TP53, GADD45A | More | | | Glyburide | hsa05217 | Basal cell carcinoma | 5.20E-05 | 5 | Q13635, P49841, Q9UJU2, P04637, P24522 | PTCH1, GSK3B, LEF1, TP53, GADD45A | More | | | Glyburide | hsa05218 | Melanoma | 2.77E-03 | 4 | Q9NRA1, P42338, P04049, O75293 | PDGFC, PIK3CB, RAF1, GADD45B | More | | | Glyburide | hsa05219 | Bladder cancer | 4.98E-03 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05220 | Chronic myeloid leukemia | 1.72E-03 | 6 | Q13547, P01106, P25963, P42338, P04049, O75293 | HDAC1, MYC, NFKBIA, PIK3CB, RAF1, GADD45B | More | | | Glyburide | hsa05221 | Acute myeloid leukemia | 8.29E-03 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05223 | Non-small cell lung cancer | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05224 | Breast cancer | 1.49E-02 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05225 | Hepatocellular carcinoma | 6.30E-04 | 3 | P04049, Q92529, P51531 | RAF1, SHC3, SMARCA2 | More | | | Glyburide | hsa05226 | Gastric cancer | 3.26E-03 | 3 | P04049, Q02750, O15169 | RAF1, MAP2K1, AXIN1 | More | | | Glyburide | hsa05230 | Central carbon metabolism in cancer | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Glyburide | hsa05231 | Choline metabolism in cancer | 6.94E-04 | 6 | P04049, P42338, Q9NRA1, Q9Y259, P19174, P23743 | RAF1, PIK3CB, PDGFC, CHKB, PLCG1, DGKA | More | | | Glyburide | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 4.46E-05 | 14 | P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, P42224, O60603, Q04759, Q16539 | NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, STAT1, TLR2, PRKCQ, MAPK14 | More | | | Glyburide | hsa05310 | Asthma | 9.08E-04 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Glyburide | hsa05321 | Inflammatory bowel disease | 1.84E-08 | 8 | O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584 | TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1B | More | | | Glyburide | hsa05322 | Systemic lupus erythematosus | 1.24E-04 | 13 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | | Glyburide | hsa05323 | Rheumatoid arthritis | 3.53E-02 | 4 | P13765, P10747, P09341, O60603 | HLA-DOB, CD28, CXCL1, TLR2 | More | | | Glyburide | hsa05332 | Graft-versus-host disease | 1.64E-03 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Glyburide | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 1.68E-03 | 1 | P54284 | CACNB3 | More | | | Glyburide | hsa05418 | Fluid shear stress and atherosclerosis | 3.46E-04 | 12 | Q16539, P42338, P14598, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, Q92974 | MAPK14, PIK3CB, NCF1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, ARHGEF2 | More | |
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