PharmaCoNets of Fluconazole (SPCN: 34.57 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Fluconazolehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Fluconazolehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Fluconazolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Fluconazolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Fluconazolehsa00630Glyoxylate and dicarboxylate metabolism1.32E-022P40925, P15104MDH1, GLULMore
Fluconazolehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Fluconazolehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Fluconazolehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Fluconazolehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Fluconazolehsa03040Spliceosome4.19E-0410Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1More
Fluconazolehsa04012ErbB signaling pathway1.34E-024P16333, P19174, P42338, P01106NCK1, PLCG1, PIK3CB, MYCMore
Fluconazolehsa04014Ras signaling pathway2.92E-0410P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Fluconazolehsa04015Rap1 signaling pathway4.83E-038P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1More
Fluconazolehsa04020Calcium signaling pathway2.61E-026P27987, P21796, P19174, P0DP23, Q9NRA1, P49767ITPKB, VDAC1, PLCG1, CALM1, PDGFC, VEGFCMore
Fluconazolehsa04062Chemokine signaling pathway3.26E-0411P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIAMore
Fluconazolehsa04070Phosphatidylinositol signaling system1.12E-025P19174, P0DP23, P42338, P23743, P27987PLCG1, CALM1, PIK3CB, DGKA, ITPKBMore
Fluconazolehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Fluconazolehsa04072Phospholipase D signaling pathway4.67E-025P42338, P19174, Q14344, P23743, Q9NRA1PIK3CB, PLCG1, GNA13, DGKA, PDGFCMore
Fluconazolehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Fluconazolehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Fluconazolehsa04151PI3K-Akt signaling pathway5.62E-0312P42338, P01106, P20827, Q9NRA1, P49767, P08238, P62873, P63218, P50151, O15335, P14784, P01568PIK3CB, MYC, EFNA1, PDGFC, VEGFC, HSP90AB1, GNB1, GNG5, GNG10, CHAD, IL2RB, IFNA21More
Fluconazolehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Fluconazolehsa04211Longevity regulating pathway3.63E-023Q08828, Q99941, Q96RR4ADCY1, CREBL1, CAMKK2More
Fluconazolehsa04270Vascular smooth muscle contraction8.93E-034P0DP24, Q08828, P35579, P35318CALM2, ADCY1, MYH9, ADMMore
Fluconazolehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Fluconazolehsa04360Axon guidance2.87E-025P16333, P20827, O95631, P42338, P19174NCK1, EFNA1, NTN1, PIK3CB, PLCG1More
Fluconazolehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Fluconazolehsa04371Apelin signaling pathway2.41E-037P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1More
Fluconazolehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Fluconazolehsa04613Neutrophil extracellular trap formation2.06E-0311P42338, P19174, P11215, Q13547, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598PIK3CB, PLCG1, ITGAM, HDAC1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1More
Fluconazolehsa04620Toll-like receptor signaling pathway4.00E-024P01568, P42224, P25963, P42338IFNA21, STAT1, NFKBIA, PIK3CBMore
Fluconazolehsa04623Cytosolic DNA-sensing pathway3.67E-022P01568, P25963IFNA21, NFKBIAMore
Fluconazolehsa04625C-type lectin receptor signaling pathway2.17E-025Q9ULY5, P42224, P25963, P42338, P0DP23CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1More
Fluconazolehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Fluconazolehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Fluconazolehsa04658Th1 and Th2 cell differentiation8.74E-036P25963, P07766, P19174, P42224, P14784, Q13761NFKBIA, CD3E, PLCG1, STAT1, IL2RB, RUNX3More
Fluconazolehsa04659Th17 cell differentiation2.61E-026P25963, P19174, P42224, P14784, P08238, P07766NFKBIA, PLCG1, STAT1, IL2RB, HSP90AB1, CD3EMore
Fluconazolehsa04662B cell receptor signaling pathway1.12E-025P25963, P42338, P07948, P21854, Q8N149NFKBIA, PIK3CB, LYN, CD72, LILRA2More
Fluconazolehsa04664Fc epsilon RI signaling pathway1.34E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Fluconazolehsa04666Fc gamma R-mediated phagocytosis2.92E-024P07948, P42338, P19174, P14598LYN, PIK3CB, PLCG1, NCF1More
Fluconazolehsa04713Circadian entrainment4.00E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Fluconazolehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Fluconazolehsa04724Glutamatergic synapse2.92E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Fluconazolehsa04725Cholinergic synapse2.92E-024P62873, P63218, P50151, P42338GNB1, GNG5, GNG10, PIK3CBMore
Fluconazolehsa04727GABAergic synapse8.14E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Fluconazolehsa04744Phototransduction1.32E-022P62873, P0DP23GNB1, CALM1More
Fluconazolehsa04750Inflammatory mediator regulation of TRP channels4.00E-024P19174, P42338, P24723, P0DP23PLCG1, PIK3CB, PRKCH, CALM1More
Fluconazolehsa04810Regulation of actin cytoskeleton2.61E-026P12814, Q13009, P42338, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFCMore
Fluconazolehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Fluconazolehsa04914Progesterone-mediated oocyte maturation4.29E-037Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Fluconazolehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Fluconazolehsa04925Aldosterone synthesis and secretion2.27E-023Q99941, Q08828, P0DP24CREBL1, ADCY1, CALM2More
Fluconazolehsa04926Relaxin signaling pathway8.74E-036P25963, P42338, P62873, P63218, P50151, P49767NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFCMore
Fluconazolehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Fluconazolehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Fluconazolehsa05012Parkinson disease4.01E-026P21796, P60604, P19174, P0DP23, Q71U36, Q13509VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3More
Fluconazolehsa05032Morphine addiction7.60E-035P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Fluconazolehsa05034Alcoholism9.92E-0510Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Fluconazolehsa05132Salmonella infection2.36E-028P25963, P08238, P01106, P42338, O75369, Q71U36, Q13509, P49754NFKBIA, HSP90AB1, MYC, PIK3CB, FLNB, TUBA1A, TUBB3, VPS41More
Fluconazolehsa05162Measles1.84E-027P01568, P25963, P42224, P14784, P07766, P42338, P11142IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8More
Fluconazolehsa05163Human cytomegalovirus infection9.45E-0515P42338, P25963, P62873, P63218, P50151, P0DP23, P0DP24, Q14344, Q08828, P23458, P01106, P61073, Q99941, P30101, P01568PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, CALM2, GNA13, ADCY1, JAK1, MYC, CXCR4, CREBL1, PDIA3, IFNA21More
Fluconazolehsa05167Kaposi sarcoma-associated herpesvirus infection4.21E-0615P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBBMore
Fluconazolehsa05168Herpes simplex virus 1 infection4.57E-0210P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189More
Fluconazolehsa05169Epstein-Barr virus infection1.08E-0311P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3EMore
Fluconazolehsa05170Human immunodeficiency virus 1 infection5.72E-0515P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1BMore
Fluconazolehsa05200Pathways in cancer1.82E-0317P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Fluconazolehsa05203Viral carcinogenesis6.72E-0411P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079, O60814PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9, H2BC12More
Fluconazolehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Fluconazolehsa05206MicroRNAs in cancer2.79E-027P30304, P09493, P01106, P42338, Q13547, P20827, P19174CDC25A, TPM1, MYC, PIK3CB, HDAC1, EFNA1, PLCG1More
Fluconazolehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Fluconazolehsa05214Glioma1.34E-024P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Fluconazolehsa05218Melanoma2.31E-023Q9NRA1, P42338, O75293PDGFC, PIK3CB, GADD45BMore
Fluconazolehsa05220Chronic myeloid leukemia2.17E-025Q13547, P01106, P25963, P42338, O75293HDAC1, MYC, NFKBIA, PIK3CB, GADD45BMore
Fluconazolehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Fluconazolehsa05231Choline metabolism in cancer2.92E-035P42338, Q9NRA1, Q9Y259, P19174, P23743PIK3CB, PDGFC, CHKB, PLCG1, DGKAMore
Fluconazolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.71E-025P25963, P42338, P19174, P07766, P42224NFKBIA, PIK3CB, PLCG1, CD3E, STAT1More
Fluconazolehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Fluconazole (SDC: 3.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O43521BCL2L11BclNone2Nonelike protein 11Predicted00.50590.04950.6310.9829
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)