PharmaCoNets of Etidronic-acid (SPCN: 12.75 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Etidronic-acidhsa00010Glycolysis / Gluconeogenesis2.17E-023P04075, P04406, P60174ALDOA, GAPDH, TPI1More
Etidronic-acidhsa00020Citrate cycle (TCA cycle)3.65E-022O75390, P40926CS, MDH2More
Etidronic-acidhsa00051Fructose and mannose metabolism2.48E-022P60174, P04075TPI1, ALDOAMore
Etidronic-acidhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Etidronic-acidhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Etidronic-acidhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Etidronic-acidhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Etidronic-acidhsa01200Carbon metabolism1.20E-024P04075, P04406, P60174, P40926ALDOA, GAPDH, TPI1, MDH2More
Etidronic-acidhsa01230Biosynthesis of amino acids1.28E-023P60174, P04406, P04075TPI1, GAPDH, ALDOAMore
Etidronic-acidhsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Etidronic-acidhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Etidronic-acidhsa03010Ribosome7.17E-0615P62753, P32969, P30050, P40429, P62906, P62917, P46776, Q9H0U6, Q07020, P61513, P36578, P27635, P05386, P62249, P23396RPS6, RPL9, RPL12, RPL13A, RPL10A, RPL8, RPL27A, MRPL18, RPL18, RPL37A, RPL4, RPL10, RPLP1, RPS16, RPS3More
Etidronic-acidhsa03013RNA transport5.54E-0315P62826, P52298, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, P11940, P20042, Q9Y6A5RAN, NCBP2, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, PABPC1, EIF2S2, TACC3More
Etidronic-acidhsa03030DNA replication3.59E-022P49005, P33993POLD2, MCM7More
Etidronic-acidhsa03040Spliceosome1.54E-026P17844, Q13435, P51991, P61978, Q15365, P11142DDX5, SF3B2, HNRPA3, HNRPK, PCBP1, HSPA8More
Etidronic-acidhsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Etidronic-acidhsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Etidronic-acidhsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Etidronic-acidhsa04141Protein processing in endoplasmic reticulum2.71E-027P18848, Q15436, P11142, Q9NXW2, Q9H3Z4, Q9NR31, P14625ATF4, SEC23A, HSPA8, DNAJB12, DNAJC5, SAR1A, HSP90B1More
Etidronic-acidhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Etidronic-acidhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Etidronic-acidhsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Etidronic-acidhsa04657IL-17 signaling pathway4.98E-026O00463, Q16539, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNFMore
Etidronic-acidhsa04714Thermogenesis4.75E-026Q92618, Q15418, P62753, P13073, Q7KZN9, O15239ZNF516, RPS6KA1, RPS6, COX4I1, COX15, NDUFA1More
Etidronic-acidhsa04920Adipocytokine signaling pathway4.87E-022Q15831, P20333STK11, TNFRSF1BMore
Etidronic-acidhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Etidronic-acidhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Etidronic-acidhsa05010Alzheimer disease1.31E-0210O15239, P13073, Q00535, P01584, P18848, O15169, P67870, P05141, P28070, P43686NDUFA1, COX4I1, CDK5, IL1B, ATF4, AXIN1, CSNK2B, SLC25A5, PSMB4, PSMC4More
Etidronic-acidhsa05020Prion disease1.09E-0210P01584, P46531, P11142, O15239, P13073, P18848, P05141, P28070, P43686, P67870IL1B, NOTCH1, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5, PSMB4, PSMC4, CSNK2BMore
Etidronic-acidhsa05022Pathways of neurodegeneration - multiple diseases6.24E-0312P67870, O15239, P13073, P18848, P05141, P20333, Q00535, O15169, P01584, Q13557, P28070, P43686CSNK2B, NDUFA1, COX4I1, ATF4, SLC25A5, TNFRSF1B, CDK5, AXIN1, IL1B, CAMK2D, PSMB4, PSMC4More
Etidronic-acidhsa05133Pertussis4.20E-021P0C0L4C4AMore
Etidronic-acidhsa05134Legionellosis2.00E-024P01584, Q9NR31, P68104, P11142IL1B, SAR1A, EEF1A1, HSPA8More
Etidronic-acidhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Etidronic-acidhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Etidronic-acidhsa05171Coronavirus disease - COVID-196.10E-0515P01584, P23396, P62753, P62249, P40429, P62906, P36578, P62917, P32969, P27635, P30050, Q07020, P46776, P61513, P05386IL1B, RPS3, RPS6, RPS16, RPL13A, RPL10A, RPL4, RPL8, RPL9, RPL10, RPL12, RPL18, RPL27A, RPL37A, RPLP1More
Etidronic-acidhsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Etidronic-acidhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Etidronic-acid (SDC: 2.85)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)