PharmaCoNets of Estradiol-acetate (SPCN: 93.20 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Estradiol-acetatehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Estradiol-acetatehsa00030Pentose phosphate pathway3.67E-033P60891, P11413, P37837PRPS1, G6PD, TALDO1More
Estradiol-acetatehsa00071Fatty acid degradation3.43E-044O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Estradiol-acetatehsa00190Oxidative phosphorylation2.11E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Estradiol-acetatehsa00220Arginine biosynthesis1.94E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Estradiol-acetatehsa00250Alanine, aspartate and glutamate metabolism4.32E-022P49448, P15104GLUD2, GLULMore
Estradiol-acetatehsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Estradiol-acetatehsa00500Starch and sucrose metabolism1.59E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Estradiol-acetatehsa00520Amino sugar and nucleotide sugar metabolism7.87E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Estradiol-acetatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Estradiol-acetatehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Estradiol-acetatehsa00591Linoleic acid metabolism1.29E-031P11712CYP2C9More
Estradiol-acetatehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Estradiol-acetatehsa00730Thiamine metabolism3.21E-032P05186, P24666ALPL, ACP1More
Estradiol-acetatehsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Estradiol-acetatehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Estradiol-acetatehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Estradiol-acetatehsa00910Nitrogen metabolism4.32E-022P15104, P49448GLUL, GLUD2More
Estradiol-acetatehsa00970Aminoacyl-tRNA biosynthesis2.75E-064O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Estradiol-acetatehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Estradiol-acetatehsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Estradiol-acetatehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Estradiol-acetatehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Estradiol-acetatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Estradiol-acetatehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Estradiol-acetatehsa01230Biosynthesis of amino acids3.27E-035P51854, P60891, Q99707, P50213, P37837TKTL1, PRPS1, MTR, IDH3A, TALDO1More
Estradiol-acetatehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Estradiol-acetatehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Estradiol-acetatehsa03008Ribosome biogenesis in eukaryotes2.40E-035P19784, P67870, O14980, O60832, Q9BVP2CSNK2A2, CSNK2B, XPO1, DKC1, GNL3More
Estradiol-acetatehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Estradiol-acetatehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Estradiol-acetatehsa03320PPAR signaling pathway3.78E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Estradiol-acetatehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Estradiol-acetatehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Estradiol-acetatehsa04062Chemokine signaling pathway2.83E-0514P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Estradiol-acetatehsa04064NF-kappa B signaling pathway1.16E-0621P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Estradiol-acetatehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Estradiol-acetatehsa04072Phospholipase D signaling pathway5.37E-038P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNASMore
Estradiol-acetatehsa04080Neuroactive ligand-receptor interaction1.23E-0310P08311, P48058, Q15722, P21453, Q9H228, P43657, O00398, P21730, P07550, P35318CTSG, GRIA4, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, C5AR1, ADRB2, ADMMore
Estradiol-acetatehsa04114Oocyte meiosis1.62E-045Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Estradiol-acetatehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Estradiol-acetatehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Estradiol-acetatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Estradiol-acetatehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Estradiol-acetatehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Estradiol-acetatehsa04150mTOR signaling pathway4.72E-036P42338, Q02750, Q9NQL2, P51812, Q13322, P49841PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3BMore
Estradiol-acetatehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Estradiol-acetatehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Estradiol-acetatehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Estradiol-acetatehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Estradiol-acetatehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Estradiol-acetatehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Estradiol-acetatehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Estradiol-acetatehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Estradiol-acetatehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Estradiol-acetatehsa04370VEGF signaling pathway1.43E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Estradiol-acetatehsa04380Osteoclast differentiation3.40E-0414Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Estradiol-acetatehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Estradiol-acetatehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Estradiol-acetatehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Estradiol-acetatehsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Estradiol-acetatehsa04612Antigen processing and presentation1.93E-037P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Estradiol-acetatehsa04613Neutrophil extracellular trap formation1.31E-0623P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Estradiol-acetatehsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Estradiol-acetatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Estradiol-acetatehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Estradiol-acetatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Estradiol-acetatehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Estradiol-acetatehsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Estradiol-acetatehsa04640Hematopoietic cell lineage1.16E-0415P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Estradiol-acetatehsa04650Natural killer cell mediated cytotoxicity8.54E-1316P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Estradiol-acetatehsa04657IL-17 signaling pathway1.56E-028O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Estradiol-acetatehsa04658Th1 and Th2 cell differentiation1.22E-1215Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Estradiol-acetatehsa04659Th17 cell differentiation6.65E-1118P25963, Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3E, CD3G, CD247, JAK1More
Estradiol-acetatehsa04660T cell receptor signaling pathway1.91E-1117P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Estradiol-acetatehsa04662B cell receptor signaling pathway2.80E-036P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Estradiol-acetatehsa04664Fc epsilon RI signaling pathway1.80E-024Q16539, P42338, P07948, P09917MAPK14, PIK3CB, LYN, ALOX5More
Estradiol-acetatehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Estradiol-acetatehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Estradiol-acetatehsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Estradiol-acetatehsa04720Long-term potentiation7.72E-043P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Estradiol-acetatehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Estradiol-acetatehsa04723Retrograde endocannabinoid signaling5.93E-036P48169, P62873, P63218, P50151, P48058, Q16539GABRA4, GNB1, GNG5, GNG10, GRIA4, MAPK14More
Estradiol-acetatehsa04724Glutamatergic synapse6.91E-047P48058, P43003, P63092, P62873, P63218, P50151, P15104GRIA4, SLC1A3, GNAS, GNB1, GNG5, GNG10, GLULMore
Estradiol-acetatehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Estradiol-acetatehsa04728Dopaminergic synapse1.85E-037P14416, P63218, P50151, P49841, Q16539, P49407, P48058DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4More
Estradiol-acetatehsa04750Inflammatory mediator regulation of TRP channels3.14E-0411P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Estradiol-acetatehsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Estradiol-acetatehsa04914Progesterone-mediated oocyte maturation5.67E-044Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Estradiol-acetatehsa04920Adipocytokine signaling pathway2.62E-033Q06124, Q9Y478, Q96RR4PTPN11, PRKAB1, CAMKK2More
Estradiol-acetatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Estradiol-acetatehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Estradiol-acetatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Estradiol-acetatehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Estradiol-acetatehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Estradiol-acetatehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Estradiol-acetatehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Estradiol-acetatehsa04973Carbohydrate digestion and absorption2.02E-042O43451, P42338MGAM, PIK3CBMore
Estradiol-acetatehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Estradiol-acetatehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Estradiol-acetatehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Estradiol-acetatehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Estradiol-acetatehsa05032Morphine addiction2.47E-033P62873, P48169, P63092GNB1, GABRA4, GNASMore
Estradiol-acetatehsa05034Alcoholism3.52E-067Q13547, Q93077, P62807, P58876, Q16778, O60814, P68431HDAC1, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Estradiol-acetatehsa05120Epithelial cell signaling in Helicobacter pylori infection2.38E-067Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Estradiol-acetatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Estradiol-acetatehsa05132Salmonella infection5.76E-047P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2CMore
Estradiol-acetatehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Estradiol-acetatehsa05135Yersinia infection1.11E-0512Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01730, P01732PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD4, CD8AMore
Estradiol-acetatehsa05140Leishmaniasis5.95E-0412P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MAPK14, NCF4More
Estradiol-acetatehsa05144Malaria1.35E-046P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Estradiol-acetatehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Estradiol-acetatehsa05146Amoebiasis1.06E-0513P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Estradiol-acetatehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Estradiol-acetatehsa05163Human cytomegalovirus infection3.52E-0514P42338, P01375, P62873, P63218, P50151, P61586, P49841, P14778, Q13651, P25025, Q16539, P63092, O00463, P61769PIK3CB, TNF, GNB1, GNG5, GNG10, RHOA, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, GNAS, TRAF5, B2MMore
Estradiol-acetatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Estradiol-acetatehsa05169Epstein-Barr virus infection2.32E-029Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247More
Estradiol-acetatehsa05170Human immunodeficiency virus 1 infection8.23E-045Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Estradiol-acetatehsa05202Transcriptional misregulation in cancer2.04E-0419Q12778, Q13315, P17844, P14780, P27930, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, ATM, DDX5, MMP9, IL1R2, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Estradiol-acetatehsa05203Viral carcinogenesis1.46E-058Q12933, P42229, Q13547, Q15283, P62807, P58876, Q16778, O60814TRAF2, STAT5A, HDAC1, RASA2, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12More
Estradiol-acetatehsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Estradiol-acetatehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Estradiol-acetatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Estradiol-acetatehsa05212Pancreatic cancer4.21E-033P37173, P84022, Q13485TGFBR2, SMAD3, SMAD4More
Estradiol-acetatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Estradiol-acetatehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Estradiol-acetatehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Estradiol-acetatehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Estradiol-acetatehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Estradiol-acetatehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Estradiol-acetatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.49E-0713P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4More
Estradiol-acetatehsa05321Inflammatory bowel disease8.20E-057O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Estradiol-acetatehsa05322Systemic lupus erythematosus5.41E-077P09871, Q93077, P62807, P58876, Q16778, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Estradiol-acetatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Estradiol-acetatehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Estradiol-acetatehsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Estradiol-acetatehsa05415Diabetic cardiomyopathy4.92E-035Q16718, O14521, Q16539, P49841, P11413NDUFA5, SDHD, MAPK14, GSK3B, G6PDMore
Estradiol-acetatehsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Estradiol-acetate (SDC: 6.05)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)