PharmaCoNets

PharmaCoNets of Conivaptan (S_PCN: 299.51 )

Conivaptan regulated-network (S_DN: 29.39)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Conivaptan

hsa00030

Pentose phosphate pathway

1.94E-03

P60891, P52209, P37837

PRPS1, PGD, TALDO1

Conivaptan

hsa00052

Galactose metabolism

6.39E-04

P06280, O43451

GLA, MGAM

Conivaptan

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Conivaptan

hsa00061

Fatty acid biosynthesis

4.83E-02

P33121

ACSL1

Conivaptan

hsa00071

Fatty acid degradation

1.81E-03

P11310, O75521, P00325, P11766, P28332, P33121

ACADM, ECI2, ADH1B, ADH5, ADH6, ACSL1

Conivaptan

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Conivaptan

hsa00190

Oxidative phosphorylation

2.80E-06

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Conivaptan

hsa00220

Arginine biosynthesis

4.40E-02

P15104

GLUL

Conivaptan

hsa00230

Purine metabolism

1.56E-02

Q7LG56, P51828, Q9Y227

RRM2B, ADCY7, ENTPD4

Conivaptan

hsa00240

Pyrimidine metabolism

1.45E-02

Q7LG56, Q9Y227

RRM2B, ENTPD4

Conivaptan

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Conivaptan

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Conivaptan

hsa00500

Starch and sucrose metabolism

9.97E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Conivaptan

hsa00512

Mucin type O-glycan biosynthesis

3.19E-03

O95395, Q8N4A0, Q9NY28

GCNT3, GALNT4, GALNT8

Conivaptan

hsa00513

Various types of N-glycan biosynthesis

4.83E-02

Q9NR34

MAN1C1

Conivaptan

hsa00520

Amino sugar and nucleotide sugar metabolism

1.59E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Conivaptan

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Conivaptan

hsa00561

Glycerolipid metabolism

4.33E-04

O14494, P06280, P23743

PLPP1, GLA, DGKA

Conivaptan

hsa00564

Glycerophospholipid metabolism

2.80E-02

P23743, O14494, Q3LIE5

DGKA, PLPP1, ADPRM

Conivaptan

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Conivaptan

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Conivaptan

hsa00591

Linoleic acid metabolism

1.95E-03

P11712

CYP2C9

Conivaptan

hsa00600

Sphingolipid metabolism

3.70E-03

P07602, Q9BX95, Q13510, O14494, P06280

PSAP, SGPP1, ASAH1, PLPP1, GLA

Conivaptan

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Conivaptan

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

7.10E-03

P06865, O75752

HEXA, B3GALNT1

Conivaptan

hsa00630

Glyoxylate and dicarboxylate metabolism

1.36E-07

P40925, P40926, P15104

MDH1, MDH2, GLUL

Conivaptan

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Conivaptan

hsa00730

Thiamine metabolism

1.84E-06

P05186, P24666

ALPL, ACP1

Conivaptan

hsa00750

Vitamin B6 metabolism

3.56E-02

O00764

PDXK

Conivaptan

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Conivaptan

hsa00830

Retinol metabolism

1.54E-05

P00325, P11766, Q9BPW9, O75911, P11712

ADH1B, ADH5, DHRS9, DHRS3, CYP2C9

Conivaptan

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Conivaptan

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Conivaptan

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Conivaptan

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Conivaptan

hsa00983

Drug metabolism - other enzymes

8.82E-04

P20839, P32320, P05164, Q16772

IMPDH1, CDA, MPO, GSTA3

Conivaptan

hsa01100

Metabolic pathways

6.34E-04

Q9NR34, Q9Y234, P05089, O14521, Q99707, P11310, P27707, P32320, Q3LIE5, P22748, P55809, P06280, Q16875, O43286, O43451, P11712, P05186, P24666, P23743, O14494, Q02252, O60701, O14772, P28332, Q9HCC0, P33121, P04406, Q9NY28, P57054, Q9UNP4, Q9BX95, Q53FZ2, P09960, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q13488, Q16718, Q02809

MAN1C1, LIPT1, ARG1, SDHD, MTR, ACADM, DCK, CDA, ADPRM, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CYP2C9, ALPL, ACP1, DGKA, PLPP1, ALDH6A1, UGDH, FPGT, ADH6, MCCC2, ACSL1, GAPDH, GALNT8, PIGP, ST3GAL5, SGPP1, ACSM3, LTA4H, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, TCIRG1, NDUFA5, PLOD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.705
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.814
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q99707	MTR	Methionine synthase	0.725
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.909
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P27707	DCK	Deoxycytidine kinase	0.85
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q3LIE5	ADPRM	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P06280	GLA	Alpha-galactosidase A	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P11712	CYP2C9	Cytochrome P450 2C9	0.761
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.704
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P23743	DGKA	Diacylglycerol kinase alpha	-0.77
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O14494	PLPP1	Phospholipid phosphatase 1	0.756
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.803
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O60701	UGDH	UDP-glucose 6-dehydrogenase	0.858
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O14772	FPGT	Fucose-1-phosphate guanylyltransferase	0.897
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P28332	ADH6	Alcohol dehydrogenase 6	0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.757
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.777
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q9NY28	GALNT8	Probable polypeptide N-acetylgalactosaminyltransferase 8	0.876
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	0.753
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P09960	LTA4H	Leukotriene A-4 hydrolase	-0.874
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q9UHY7	ENOPH1	Enolase-phosphatase E1	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.79
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.755
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q02809	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	-0.724

Conivaptan

hsa01210

2-Oxocarboxylic acid metabolism

2.50E-05

P50213

IDH3A

Conivaptan

hsa01230

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Conivaptan

hsa01521

EGFR tyrosine kinase inhibitor resistance

3.18E-04

P04049, P08069

RAF1, IGF1R

Conivaptan

hsa01522

Endocrine resistance

4.22E-03

P22694, P04049, P08069, P10415, Q13323

PRKACB, RAF1, IGF1R, BCL2, BIK

Conivaptan

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Conivaptan

hsa01524

Platinum drug resistance

6.89E-04

P10415, Q13489, P98170, P78417, P23025, P43246, P31751

BCL2, BIRC3, BIRC4, GSTO1, XPA, MSH2, AKT2

Conivaptan

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Conivaptan

hsa03008

Ribosome biogenesis in eukaryotes

1.37E-03

O14980, O60832, P78345, Q9BVP2

XPO1, DKC1, RPP38, GNL3

Conivaptan

hsa03010

Ribosome

7.34E-03

P62753, P62829, P62888, P61927, P61513, P36578

RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4

Conivaptan

hsa03013

RNA transport

1.21E-07

O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812

Conivaptan

hsa03020

RNA polymerase

2.06E-03

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Conivaptan

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Conivaptan

hsa03040

Spliceosome

9.46E-12

Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Conivaptan

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Conivaptan

hsa03060

Protein export

1.20E-03

P37108, Q15005

SRP14, SPCS2

Conivaptan

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Conivaptan

hsa04010

MAPK signaling pathway

1.69E-03

P04049, P08069

RAF1, IGF1R

Conivaptan

hsa04012

ErbB signaling pathway

6.03E-04

P21860, P16333, Q13557, P19174, O14944, P01106, P04049

ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1

Conivaptan

hsa04014

Ras signaling pathway

2.30E-06

P04049, P31751, P42338, P20827, Q9NRA1, P49767, P08069, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174

RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.776
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Conivaptan

hsa04015

Rap1 signaling pathway

1.66E-05

P04049, P20827, P49767, P08069, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P31751, P0DP23, P08514, P19174

RAF1, EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, ITGA2B, PLCG1

Conivaptan

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Conivaptan

hsa04022

cGMP-PKG signaling pathway

2.77E-05

P24844, P04049, Q99941, P23634, Q8WYR1, P31751, P51828, P45880, Q15746, P0DP23

MYL9, RAF1, CREBL1, ATP2B4, PIK3R5, AKT2, ADCY7, VDAC2, MYLK, CALM1

Conivaptan

hsa04024

cAMP signaling pathway

2.44E-05

P31751, P0DP23, P04049, P48058, P25116, P24844

AKT2, CALM1, RAF1, GRIA4, F2R, MYL9

Conivaptan

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Conivaptan

hsa04062

Chemokine signaling pathway

2.94E-07

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43250	GRK6	G protein-coupled receptor kinase 6	0.815
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Conivaptan

hsa04064

NF-kappa B signaling pathway

3.56E-09

P10415, Q13489, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.832
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16548	BCL2A1	Bcl-2-related protein A1	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q8WV28	BLNK	B-cell linker protein	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Conivaptan

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Conivaptan

hsa04068

FoxO signaling pathway

3.80E-04

P04049, P08069

RAF1, IGF1R

Conivaptan

hsa04070

Phosphatidylinositol signaling system

2.93E-02

P19174, P0DP23, P23743, P27987

PLCG1, CALM1, DGKA, ITPKB

Conivaptan

hsa04071

Sphingolipid signaling pathway

4.31E-08

P04049, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, P01042

RAF1, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42892	ECE1	Endothelin-converting enzyme 1	Q13510	ASAH1	Acid ceramidase	0.748
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P42892	ECE1	Endothelin-converting enzyme 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.708
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P42892	ECE1	Endothelin-converting enzyme 1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.894
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.708
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P01042	KNG1	Kininogen-1	-0.773

Conivaptan

hsa04072

Phospholipase D signaling pathway

3.15E-03

P04049, P42338, Q9UQC2, P43657, P25024, P25025, P19174, Q8WYR1, Q08828

RAF1, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIK3R5, ADCY1

Conivaptan

hsa04080

Neuroactive ligand-receptor interaction

3.66E-06

P08311, Q15722, P21453, Q9H228, O00398, P25116, P21462, P21730, Q16581, P07550, P01042, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY10, F2R, FPR1, C5AR1, C3AR1, ADRB2, KNG1, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P25116	F2R	Proteinase-activated receptor 1	-0.791
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P01042	KNG1	Kininogen-1	-0.773
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727

Conivaptan

hsa04110

Cell cycle

8.83E-05

Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106

ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC

Conivaptan

hsa04114

Oocyte meiosis

4.41E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Conivaptan

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Conivaptan

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Conivaptan

hsa04140

Autophagy - animal

2.40E-03

P08069, P04049, P22694, Q14643, P10415, Q04759

IGF1R, RAF1, PRKACB, ITPR1, BCL2, PRKCQ

Conivaptan

hsa04141

Protein processing in endoplasmic reticulum

9.90E-07

P18848, P30101, P07384, O95487, Q15437, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, O95816, Q9H173, Q9UNL2

ATF4, PDIA3, CAPN1, SEC24B, SEC23B, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, BAG2, SIL1, SSR3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q15437	SEC23B	Protein transport protein Sec23B	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.775
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.7
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9H173	SIL1	Nucleotide exchange factor SIL1	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9UNL2	SSR3	Translocon-associated protein subunit gamma	-0.706

Conivaptan

hsa04142

Lysosome

6.04E-06

P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900, Q9Y227

HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164, ENTPD4

Conivaptan

hsa04144

Endocytosis

3.18E-06

P0DMV8, Q9H444, O75351, P62491, P42566, Q96B97, Q15438, Q8WU79, Q14161, Q9UMY4, Q9UNH7

HSPA1A, CHMP4B, VPS4B, RAB11A, EPS15, SH3KBP1, PSCD1, SMAP1L, GIT2, SNX12, SNX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.81
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.81
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.862
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.722
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.765
P23458	JAK1	Tyrosine-protein kinase JAK1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.707
Q9GZT9	EGLN1	Egl nine homolog 1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.767
P23458	JAK1	Tyrosine-protein kinase JAK1	P62491	RAB11A	Ras-related protein Rab-11A	0.854
Q9GZT9	EGLN1	Egl nine homolog 1	P62491	RAB11A	Ras-related protein Rab-11A	0.719
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	P62491	RAB11A	Ras-related protein Rab-11A	0.822
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.838
P23458	JAK1	Tyrosine-protein kinase JAK1	Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	0.716
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	Q15438	PSCD1	Cytohesin-1	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15438	PSCD1	Cytohesin-1	0.756
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	Q8WU79	SMAP1L	Stromal membrane-associated protein 2	0.781
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.77
P23458	JAK1	Tyrosine-protein kinase JAK1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.817
Q9GZT9	EGLN1	Egl nine homolog 1	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.723
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	Q14161	GIT2	ARF GTPase-activating protein GIT2	0.737
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9UMY4	SNX12	Sorting nexin-12	0.835
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	Q9UMY4	SNX12	Sorting nexin-12	0.79
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	Q9UNH7	SNX6	Sorting nexin-6	0.799

Conivaptan

hsa04145

Phagosome

9.85E-07

P11215, P60709, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ITGAM, ACTB, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P10415	BCL2	Apoptosis regulator Bcl-2	Q15080	NCF4	Neutrophil cytosol factor 4	-0.951
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P10415	BCL2	Apoptosis regulator Bcl-2	P14598	NCF1	Neutrophil cytosol factor 1	-0.844
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.759
P10415	BCL2	Apoptosis regulator Bcl-2	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.718
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P10415	BCL2	Apoptosis regulator Bcl-2	P35443	THBS4	Thrombospondin-4	-0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P10415	BCL2	Apoptosis regulator Bcl-2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Conivaptan

hsa04150

mTOR signaling pathway

5.20E-04

P08069, P04049

IGF1R, RAF1

Conivaptan

hsa04151

PI3K-Akt signaling pathway

6.51E-06

P62753, P42338, P43657, O43521, P27348, P20827, P49767, Q13362, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P22105, P14784, P23458, Q99941, P18848, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, JAK1, CREBL1, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P42892	ECE1	Endothelin-converting enzyme 1	O43521	BCL2L11	Bcl-2-like protein 11	0.736
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P42892	ECE1	Endothelin-converting enzyme 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.733
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P42892	ECE1	Endothelin-converting enzyme 1	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P42892	ECE1	Endothelin-converting enzyme 1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.797
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P42892	ECE1	Endothelin-converting enzyme 1	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.747
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Conivaptan

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Conivaptan

hsa04210

Apoptosis

4.72E-04

Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643, P04049

ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1, RAF1

Conivaptan

hsa04211

Longevity regulating pathway

5.33E-03

P08069, P51828, Q99941, P18848

IGF1R, ADCY7, CREBL1, ATF4

Conivaptan

hsa04213

Longevity regulating pathway - multiple species

5.94E-06

P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Conivaptan

hsa04215

Apoptosis - multiple species

3.01E-02

Q13489, P10415

BIRC3, BCL2

Conivaptan

hsa04217

Necroptosis

1.70E-06

P01375, P01568, P48023, Q13489, P98170, Q9NQC7, Q14765, P07900, P08238, P15104, P01584, Q6FI13, Q99878, Q9H444, O43633, P21796, Q08752

TNF, IFNA21, FASLG, BIRC3, BIRC4, CYLD, STAT4, HSP90AA1, HSP90AB1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, CHMP4B, CHMP2A, VDAC1, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P01568	IFNA21	Interferon alpha-21	0.785
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.815
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.749
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.729
O00141	SGK	Serine/threonine-protein kinase Sgk1	P15104	GLUL	Glutamine synthetase	0.761
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P15104	GLUL	Glutamine synthetase	0.745
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.737
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.717
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.767
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.844
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.75

Conivaptan

hsa04218

Cellular senescence

1.43E-04

P31751, P04049, P0DP23

AKT2, RAF1, CALM1

Conivaptan

hsa04260

Cardiac muscle contraction

4.02E-02

P09493, P14927

TPM1, UQCRB

Conivaptan

hsa04261

Adrenergic signaling in cardiomyocytes

1.15E-04

P51828, P31751, Q99941, P18848, P0DP23, Q13557, P23634

ADCY7, AKT2, CREBL1, ATF4, CALM1, CAMK2D, ATP2B4

Conivaptan

hsa04270

Vascular smooth muscle contraction

1.02E-07

Q15746, P24844, P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318

MYLK, MYL9, CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADM

Conivaptan

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Conivaptan

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Conivaptan

hsa04340

Hedgehog signaling pathway

3.19E-07

P49841, P17612, P22694, Q13635, P10415

GSK3B, PRKACA, PRKACB, PTCH1, BCL2

Conivaptan

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Conivaptan

hsa04360

Axon guidance

6.05E-05

P16333, P20827, O95631, P42338, P07332, P23528, P04049, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, RAF1, PLCG1, PTPN11

Conivaptan

hsa04370

VEGF signaling pathway

1.26E-04

P16298, P31751, Q05397, Q02750, P04049

PPP3CB, AKT2, PTK2, MAP2K1, RAF1

Conivaptan

hsa04371

Apelin signaling pathway

2.73E-09

P62873, P63218, P50151, Q8WYR1, P31751, P04049, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PIK3R5, AKT2, RAF1, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.826
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761

Conivaptan

hsa04380

Osteoclast differentiation

1.35E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Conivaptan

hsa04390

Hippo signaling pathway

2.41E-03

P63261, O15105, P04628, O43623

ACTG1, SMAD7, WNT1, SNAI2

Conivaptan

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Conivaptan

hsa04510

Focal adhesion

2.26E-04

P16144, P08514, Q15746, P24844, Q15942, Q13489, P10415, P04049, P08069

ITGB4, ITGA2B, MYLK, MYL9, ZYX, BIRC3, BCL2, RAF1, IGF1R

Conivaptan

hsa04512

ECM-receptor interaction

2.44E-02

P07359, P08514

GP1BA, ITGA2B

Conivaptan

hsa04514

Cell adhesion molecules

4.65E-02

P16109, O00501

SELP, CLDN5

Conivaptan

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Conivaptan

hsa04530

Tight junction

8.69E-07

Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247, P24844

RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN, MYL9

Conivaptan

hsa04540

Gap junction

1.73E-04

P22694, Q13509, P68371, Q71U36, P04049, Q9NRA1, Q14643

PRKACB, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC, ITPR1

Conivaptan

hsa04550

Signaling pathways regulating pluripotency of stem cells

2.80E-04

P04628, P40189, P04049, P08069, P14653

WNT1, IL6ST, RAF1, IGF1R, HOXB1

Conivaptan

hsa04610

Complement and coagulation cascades

1.96E-08

P25116, P01042, P0C0L4, P10909, Q16581

F2R, KNG1, C4A, CLU, C3AR1

Conivaptan

hsa04611

Platelet activation

8.96E-08

P25116, Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P17612, P07359

F2R, TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, PRKACA, GP1BA

Conivaptan

hsa04612

Antigen processing and presentation

5.83E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Conivaptan

hsa04613

Neutrophil extracellular trap formation

1.36E-06

P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Conivaptan

hsa04614

Renin-angiotensin system

7.48E-03

P50052, P15144, P08311, O75787

AGTR2, ANPEP, CTSG, ATP6AP2

Conivaptan

hsa04620

Toll-like receptor signaling pathway

4.78E-02

P31751

AKT2

Conivaptan

hsa04621

NOD-like receptor signaling pathway

1.37E-05

P01584, P07900, Q16539, Q14643, P23458, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P42892	ECE1	Endothelin-converting enzyme 1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.797
P42892	ECE1	Endothelin-converting enzyme 1	Q9H3M7	TXNIP	Thioredoxin-interacting protein	0.747
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
O00141	SGK	Serine/threonine-protein kinase Sgk1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P42892	ECE1	Endothelin-converting enzyme 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.815
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7

Conivaptan

hsa04622

RIG-I-like receptor signaling pathway

1.81E-02

Q9NQC7

CYLD

Conivaptan

hsa04623

Cytosolic DNA-sensing pathway

3.64E-05

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Conivaptan

hsa04625

C-type lectin receptor signaling pathway

3.02E-05

Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539

CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14

Conivaptan

hsa04630

JAK-STAT signaling pathway

3.67E-03

P48551, P40189, Q06124, P04049

IFNAR2, IL6ST, PTPN11, RAF1

Conivaptan

hsa04640

Hematopoietic cell lineage

6.79E-04

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B

Conivaptan

hsa04650

Natural killer cell mediated cytotoxicity

3.12E-07

P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Conivaptan

hsa04657

IL-17 signaling pathway

1.85E-06

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Conivaptan

hsa04658

Th1 and Th2 cell differentiation

2.06E-09

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Conivaptan

hsa04659

Th17 cell differentiation

3.19E-09

P25963, Q04759, Q16539, P19174, P06239, P42224, P42226, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Conivaptan

hsa04660

T cell receptor signaling pathway

3.61E-08

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Conivaptan

hsa04662

B cell receptor signaling pathway

1.49E-06

P31751, P42338, P60033, P07948, P21854, Q8N149, P04049

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1

Conivaptan

hsa04664

Fc epsilon RI signaling pathway

1.07E-08

P31751, P04141, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292

AKT2, CSF2, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5AP

Conivaptan

hsa04666

Fc gamma R-mediated phagocytosis

2.64E-02

P04049, P23528, P06396, O14494, P14598, P17252

RAF1, CFL1, GSN, PLPP1, NCF1, PRKCA

Conivaptan

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Conivaptan

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Conivaptan

hsa04710

Circadian rhythm

4.40E-02

O15516

CLOCK

Conivaptan

hsa04713

Circadian entrainment

1.24E-04

O15399, P0DP23, P62873, P63218, P50151

GRIN2D, CALM1, GNB1, GNG5, GNG10

Conivaptan

hsa04714

Thermogenesis

1.95E-05

Q16539, P15336, P51828, P63261, P62753, P33121, Q9Y478, P12074, O15239, Q16718, O14521

MAPK14, ATF2, ADCY7, ACTG1, RPS6, ACSL1, PRKAB1, COX6A1, NDUFA1, NDUFA5, SDHD

Conivaptan

hsa04720

Long-term potentiation

9.73E-04

Q16566, P16298, P0DP23, P51812, O15399, Q02750, P04049

CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, RAF1

Conivaptan

hsa04722

Neurotrophin signaling pathway

7.07E-06

Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P0DP23

PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, CALM1

Conivaptan

hsa04724

Glutamatergic synapse

5.79E-07

P48058, O15399, P43003, P62873, P63218, P50151, P15104, Q9NSB8

GRIA4, GRIN2D, SLC1A3, GNB1, GNG5, GNG10, GLUL, HOMER2

Conivaptan

hsa04725

Cholinergic synapse

6.68E-05

P51828, P22694, Q14643, P62873, P63218, P50151, P18848, Q16566, Q13557, P10415

ADCY7, PRKACB, ITPR1, GNB1, GNG5, GNG10, ATF4, CAMK4, CAMK2D, BCL2

Conivaptan

hsa04726

Serotonergic synapse

3.61E-04

P62873, P63218, P50151, P09917, P04049

GNB1, GNG5, GNG10, ALOX5, RAF1

Conivaptan

hsa04727

GABAergic synapse

2.50E-05

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Conivaptan

hsa04728

Dopaminergic synapse

1.96E-03

P31751, Q99941, P18848, Q13557, P0DP23

AKT2, CREBL1, ATF4, CAMK2D, CALM1

Conivaptan

hsa04730

Long-term depression

4.37E-03

Q14344, P08069, P04049, P07948

GNA13, IGF1R, RAF1, LYN

Conivaptan

hsa04740

Olfactory transduction

2.41E-02

P0DP23

CALM1

Conivaptan

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Conivaptan

hsa04744

Phototransduction

1.60E-06

P62873, P0DP23

GNB1, CALM1

Conivaptan

hsa04750

Inflammatory mediator regulation of TRP channels

4.82E-06

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822

Conivaptan

hsa04810

Regulation of actin cytoskeleton

3.52E-04

P24844, Q15746, P04049, P08514, P25116

MYL9, MYLK, RAF1, ITGA2B, F2R

Conivaptan

hsa04910

Insulin signaling pathway

2.43E-05

P0DP23, P22694, P06737, P04049, P31751, P49841

CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3B

Conivaptan

hsa04911

Insulin secretion

2.03E-05

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Conivaptan

hsa04912

GnRH signaling pathway

2.65E-05

Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049, P45985

ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1, MAP2K4

Conivaptan

hsa04913

Ovarian steroidogenesis

8.54E-03

P42330, P22694, P08069

AKR1C3, PRKACB, IGF1R

Conivaptan

hsa04914

Progesterone-mediated oocyte maturation

1.02E-03

P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Conivaptan

hsa04915

Estrogen signaling pathway

1.55E-09

P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788

RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P42892	ECE1	Endothelin-converting enzyme 1	Q08828	ADCY1	Adenylate cyclase type 1	0.756
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	Q08828	ADCY1	Adenylate cyclase type 1	0.824
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P42892	ECE1	Endothelin-converting enzyme 1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.786
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.81
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P42892	ECE1	Endothelin-converting enzyme 1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.786
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.81
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	P0DP23	CALM1	Calmodulin-1	0.7
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P42892	ECE1	Endothelin-converting enzyme 1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.819
Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	Q15788	NCOA1	Nuclear receptor coactivator 1	0.723

Conivaptan

hsa04916

Melanogenesis

4.92E-03

P0DP23, Q9UJU2, P17252, P04628, P04049

CALM1, LEF1, PRKCA, WNT1, RAF1

Conivaptan

hsa04917

Prolactin signaling pathway

3.49E-04

P31751, P04049

AKT2, RAF1

Conivaptan

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Conivaptan

hsa04919

Thyroid hormone signaling pathway

6.83E-04

P49841, P04049, P22694, O60244, Q9NVC6

GSK3B, RAF1, PRKACB, MED14, MED17

Conivaptan

hsa04920

Adipocytokine signaling pathway

3.41E-03

Q06124, Q9Y478, P31751

PTPN11, PRKAB1, AKT2

Conivaptan

hsa04921

Oxytocin signaling pathway

1.14E-04

Q15746, Q08828, P04049, P24844, Q96RR4, Q8WYR1

MYLK, ADCY1, RAF1, MYL9, CAMKK2, PIK3R5

Conivaptan

hsa04922

Glucagon signaling pathway

3.14E-03

P22694, P06737, Q12778, P31751, P0DP23, Q14643

PRKACB, PYGL, FOXO1, AKT2, CALM1, ITPR1

Conivaptan

hsa04923

Regulation of lipolysis in adipocytes

3.88E-03

P07550, P42338, Q9Y4H2, P31751

ADRB2, PIK3CB, IRS2, AKT2

Conivaptan

hsa04924

Renin secretion

2.62E-06

P22694, P07550, Q14643, P0DP23

PRKACB, ADRB2, ITPR1, CALM1

Conivaptan

hsa04925

Aldosterone synthesis and secretion

2.51E-05

Q99941, P18848, P51828, Q13557, P23634

CREBL1, ATF4, ADCY7, CAMK2D, ATP2B4

Conivaptan

hsa04926

Relaxin signaling pathway

7.01E-03

Q99941, P18848, P51828, P04049

CREBL1, ATF4, ADCY7, RAF1

Conivaptan

hsa04927

Cortisol synthesis and secretion

3.03E-04

Q14643, Q99941, P18848, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY7, PRKACB

Conivaptan

hsa04928

Parathyroid hormone synthesis, secretion and action

3.61E-05

Q14643, P51828, P22694, P23771, P04049, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, RAF1, CREBL1, ATF4, BCL2

Conivaptan

hsa04929

GnRH secretion

1.87E-04

P31751, P04049

AKT2, RAF1

Conivaptan

hsa04930

Type II diabetes mellitus

2.68E-02

Q05655

PRKCD

Conivaptan

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Conivaptan

hsa04932

Non-alcoholic fatty liver disease

9.03E-06

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD

Conivaptan

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Conivaptan

hsa04934

Cushing syndrome

2.54E-06

Q14643, Q99941, P18848, P51828, P22694, O15169, Q13557, P04628

ITPR1, CREBL1, ATF4, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1

Conivaptan

hsa04935

Growth hormone synthesis, secretion and action

5.33E-03

P51828, P04049, Q99941, P18848

ADCY7, RAF1, CREBL1, ATF4

Conivaptan

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Conivaptan

hsa04960

Aldosterone-regulated sodium reabsorption

4.40E-02

O00141

SGK

Conivaptan

hsa04962

Vasopressin-regulated water reabsorption

2.95E-04

P52566, P62491, P46459

ARHGDIB, RAB11A, NSF

Conivaptan

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Conivaptan

hsa04966

Collecting duct acid secretion

2.17E-03

P00918

CA2

Conivaptan

hsa04970

Salivary secretion

3.24E-06

P07550, Q08828, P51828, P22694, Q14643, P0DP24, P0DP23

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM2, CALM1

Conivaptan

hsa04971

Gastric acid secretion

2.57E-03

P51828, P15311, P0DP23, Q13557

ADCY7, VIL2, CALM1, CAMK2D

Conivaptan

hsa04972

Pancreatic secretion

4.73E-02

Q08828, P62491

ADCY1, RAB11A

Conivaptan

hsa04973

Carbohydrate digestion and absorption

4.61E-03

O43451, P42338, P31751

MGAM, PIK3CB, AKT2

Conivaptan

hsa04976

Bile secretion

1.90E-04

O43315, Q08828, P51828, P22694, P08183, Q14032

AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Conivaptan

hsa05010

Alzheimer disease

7.84E-04

Q92542, P05496, P12074, Q00535, O75460, P0DP23, P01584, O15169, P31751, P45880

NCSTN, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, AXIN1, AKT2, VDAC2

Conivaptan

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Conivaptan

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Conivaptan

hsa05020

Prion disease

1.37E-03

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14

Conivaptan

hsa05022

Pathways of neurodegeneration - multiple diseases

8.04E-04

P49841, Q16718, O14521, Q06055, Q13561, Q16539, Q00535, Q08752, O15020, P0DP23

GSK3B, NDUFA5, SDHD, ATP5G2, DCTN2, MAPK14, CDK5, PPID, SPTBN2, CALM1

Conivaptan

hsa05030

Cocaine addiction

6.96E-03

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Conivaptan

hsa05031

Amphetamine addiction

9.24E-04

P0DP23, Q13557, Q99941, P18848

CALM1, CAMK2D, CREBL1, ATF4

Conivaptan

hsa05032

Morphine addiction

7.62E-04

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Conivaptan

hsa05034

Alcoholism

4.32E-07

O15399, Q16566, P0DP23, Q96RR4, P62873, P63218, P50151, P04049, Q93077, P62807, Q93079, O60814, P84243, P68431

GRIN2D, CAMK4, CALM1, CAMKK2, GNB1, GNG5, GNG10, RAF1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Conivaptan

hsa05100

Bacterial invasion of epithelial cells

4.54E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Conivaptan

hsa05110

Vibrio cholerae infection

5.58E-05

Q13488, Q99437, P17252, P19174, P17612, P60709

TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACA, ACTB

Conivaptan

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

5.83E-07

Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Conivaptan

hsa05130

Pathogenic Escherichia coli infection

1.35E-04

Q71U36, Q14247, O00501, P16333, Q92974, Q13509, P68371, P63261, P25116, Q14344, P25963, Q06124, O95487

TUBA1A, CTTN, CLDN5, NCK1, ARHGEF2, TUBB3, TUBB2C, ACTG1, F2R, GNA13, NFKBIA, PTPN11, SEC24B

Conivaptan

hsa05131

Shigellosis

4.50E-03

Q05655, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315, P07737

PRKCD, RRAGD, UBB, SEPT6, ELMO2, PTK2, ATM, PFN1

Conivaptan

hsa05132

Salmonella infection

1.71E-03

P51617, P25963, P08238, P04049, Q9UJU2, P84095, Q13489, P10415, O75369, P07737, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, RHOG, BIRC3, BCL2, FLNB, PFN1, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Conivaptan

hsa05133

Pertussis

3.02E-03

P0C0L4

C4A

Conivaptan

hsa05134

Legionellosis

1.05E-04

P01584, P25963, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Conivaptan

hsa05140

Leishmaniasis

5.36E-06

P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q15080	NCF4	Neutrophil cytosol factor 4	0.719

Conivaptan

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Conivaptan

hsa05144

Malaria

3.31E-04

P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1

Conivaptan

hsa05145

Toxoplasmosis

2.50E-04

Q16539, P10415, Q13489, P23458, P13765, Q8WYR1, P0DMV8

MAPK14, BCL2, BIRC3, JAK1, HLA-DOB, PIK3R5, HSPA1A

Conivaptan

hsa05146

Amoebiasis

2.17E-05

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Conivaptan

hsa05150

Staphylococcus aureus infection

4.01E-05

P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Conivaptan

hsa05152

Tuberculosis

1.89E-04

P04049, Q13488, P0DP23, P48382, O60603, P31751, P10415, P13765, P01568, Q9UDY8, Q16539, P51617

RAF1, TCIRG1, CALM1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1, MAPK14, IRAK1

Conivaptan

hsa05160

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Conivaptan

hsa05161

Hepatitis B

5.33E-03

P04049, Q99941, P18848, P27348

RAF1, CREBL1, ATF4, YWHAQ

Conivaptan

hsa05162

Measles

2.84E-03

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Conivaptan

hsa05163

Human cytomegalovirus infection

1.51E-06

P31751, P04049, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568

AKT2, RAF1, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703

Conivaptan

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Conivaptan

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.27E-07

P01568, P31751, P42224, P25963, P62873, P63218, P50151, P19174, P04049, P07948, P04141, P0DP23

IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, CSF2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761

Conivaptan

hsa05168

Herpes simplex virus 1 infection

5.00E-03

P25963, P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q13398, O75820, Q9NZL3

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF189, ZNF224

Conivaptan

hsa05169

Epstein-Barr virus infection

4.32E-02

P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963

HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247

Conivaptan

hsa05170

Human immunodeficiency virus 1 infection

4.58E-08

P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P23528, P10415, Q93034, Q9Y6Q5

AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.93
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.96
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.93
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q05397	PTK2	Focal adhesion kinase 1	0.932
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q13315	ATM	Serine-protein kinase ATM	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901

Conivaptan

hsa05171

Coronavirus disease - COVID-19

3.18E-03

P01584, P62753, P36578, P62888, P61927, P61513, P62829

IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23

Conivaptan

hsa05200

Pathways in cancer

2.93E-08

Q13751, P42338, P08238, P42224, P25963, P19174, P43246, P84022, Q13485, P20585, Q13547, P30281, Q13489, P98170, P49767, P31751, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P01042

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, SMAD4, MSH3, HDAC1, CCND3, BIRC3, BIRC4, VEGFC, AKT2, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Conivaptan

hsa05202

Transcriptional misregulation in cancer

6.18E-09

Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q16548, Q13489, Q13077, Q15652, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P68431, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	Q12778	FOXO1	Forkhead box protein O1	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q15532	SS18	Protein SSXT	-0.829
P10415	BCL2	Apoptosis regulator Bcl-2	Q15532	SS18	Protein SSXT	0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P10415	BCL2	Apoptosis regulator Bcl-2	P14923	JUP	Junction plakoglobin	0.861
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16548	BCL2A1	Bcl-2-related protein A1	0.751
P10415	BCL2	Apoptosis regulator Bcl-2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.832
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P10415	BCL2	Apoptosis regulator Bcl-2	Q13077	TRAF1	TNF receptor-associated factor 1	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	O15550	UTX	Lysine-specific demethylase 6A	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P05164	MPO	Myeloperoxidase	0.711
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P10415	BCL2	Apoptosis regulator Bcl-2	P08246	ELA2	Neutrophil elastase	-0.942
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P10415	BCL2	Apoptosis regulator Bcl-2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Conivaptan

hsa05203

Viral carcinogenesis

2.63E-03

Q99941, P18848, P27348, Q15283, P61978, P62807, O60814

CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12

Conivaptan

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Conivaptan

hsa05205

Proteoglycans in cancer

1.89E-03

Q13009, Q12955, Q14643, O75369, P04049, P14780, P17252, O60603, P08069, P04628, Q13635, P08962

TIAM1, ANK3, ITPR1, FLNB, RAF1, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63

Conivaptan

hsa05206

MicroRNAs in cancer

6.19E-04

P15311, P21860, P61978, P46531, P63279, P22105, P04049

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1

Conivaptan

hsa05210

Colorectal cancer

7.91E-03

P84022, Q13485, P43246, P04049, O75293

SMAD3, SMAD4, MSH2, RAF1, GADD45B

Conivaptan

hsa05211

Renal cell carcinoma

1.99E-04

Q06124, Q99814, P31751, P04049

PTPN11, EPAS1, AKT2, RAF1

Conivaptan

hsa05212

Pancreatic cancer

6.80E-06

P42338, P31751, P04049, P42224, P37173, P84022, Q13485, O75293

PIK3CB, AKT2, RAF1, STAT1, TGFBR2, SMAD3, SMAD4, GADD45B

Conivaptan

hsa05213

Endometrial cancer

8.16E-04

P31751, P04049

AKT2, RAF1

Conivaptan

hsa05214

Glioma

2.06E-06

P08069, P0DP23, Q16566, P04049, P31751, P19174, O75293

IGF1R, CALM1, CAMK4, RAF1, AKT2, PLCG1, GADD45B

Conivaptan

hsa05215

Prostate cancer

1.65E-04

P08069, P04049

IGF1R, RAF1

Conivaptan

hsa05217

Basal cell carcinoma

1.30E-03

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Conivaptan

hsa05218

Melanoma

5.24E-06

P08069, P31751, P04049

IGF1R, AKT2, RAF1

Conivaptan

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Conivaptan

hsa05220

Chronic myeloid leukemia

4.90E-04

Q13547, Q13485, P84022, P31751, P42338, P04049, O75293

HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, RAF1, GADD45B

Conivaptan

hsa05221

Acute myeloid leukemia

8.16E-04

P31751, P04049

AKT2, RAF1

Conivaptan

hsa05222

Small cell lung cancer

4.77E-03

P31751, Q13751, Q13489, P98170, O75293

AKT2, LAMB3, BIRC3, BIRC4, GADD45B

Conivaptan

hsa05223

Non-small cell lung cancer

3.07E-04

P17252, O43524, P31751, P19174, P04049, O75293

PRKCA, FOXO3, AKT2, PLCG1, RAF1, GADD45B

Conivaptan

hsa05224

Breast cancer

2.75E-03

P04049, P08069, P49841, Q92837, P04637, P24522

RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45A

Conivaptan

hsa05225

Hepatocellular carcinoma

1.65E-04

P04049, P08069

RAF1, IGF1R

Conivaptan

hsa05226

Gastric cancer

6.81E-04

P04049, P31751

RAF1, AKT2

Conivaptan

hsa05230

Central carbon metabolism in cancer

1.12E-03

P04049, P31751

RAF1, AKT2

Conivaptan

hsa05231

Choline metabolism in cancer

8.00E-04

P04049, Q9Y259, P19174, P23743, P49619, O14494, P17252

RAF1, CHKB, PLCG1, DGKA, DGKG, PLPP1, PRKCA

Conivaptan

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.08E-06

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707

Conivaptan

hsa05320

Autoimmune thyroid disease

8.64E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Conivaptan

hsa05321

Inflammatory bowel disease

2.20E-07

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Conivaptan

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Conivaptan

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Conivaptan

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Conivaptan

hsa05332

Graft-versus-host disease

3.29E-04

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Conivaptan

hsa05410

Hypertrophic cardiomyopathy

1.73E-02

P26012, P09493

ITGB8, TPM1

Conivaptan

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.97E-05

P54284, P15924, P26012

CACNB3, DSP, ITGB8

Conivaptan

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Conivaptan

hsa05415

Diabetic cardiomyopathy

2.61E-04

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Conivaptan

hsa05416

Viral myocarditis

2.30E-02

P10747, P63261

CD28, ACTG1

Conivaptan

hsa05418

Fluid shear stress and atherosclerosis

2.84E-03

Q16539, P31751, P10599, P14780, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1

Community members of Conivaptan (S_DC: 10.19)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

P17612

PRKACA

cAMPNonedependent protein kinase catalytic subunit alpha

Predicted

0.6937

0.5257

2.3982

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

O00141

SGK

Serine/threonineNoneprotein kinase Sgk1

Predicted

0.2413

0.3037

0.3059

1.034

Q05655

PRKCD

Protein kinase C delta type

Predicted

0.0816

0.4194

0.6544

1.5339

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

Q16581

C3AR1

C3a anaphylatoxin chemotactic receptor

Predicted

0.1388

0.0385

0.3428

0.4892

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P30530

AXL

TyrosineNoneprotein kinase receptor UFO

Predicted

0.3797

0.5365

0.1637

1.4264

Q06124

PTPN11

TyrosineNoneprotein phosphatase nonNonereceptor type 11

Predicted

0.1513

0.4566

0.613

1.6017

Q9GZT9

EGLN1

Egl nine homolog 1

Predicted

0.5804

0.6061

0.2556

1.7581

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

Q96RR4

CAMKK2

Calcium/calmodulinNonedependent protein kinase kinase 2

Predicted

0.3628

0.3406

0.4651

1.3277

P29350

PTPN6

TyrosineNoneprotein phosphatase nonNonereceptor type 6

Predicted

0.2807

0.2459

0.5683

1.2004

P08575

PTPRC

ReceptorNonetype tyrosineNoneprotein phosphatase C

Predicted

0.2733

0.1358

0.4132

0.8216

P24666

ACP1

Low molecular weight phosphotyrosine protein phosphatase

Predicted

0.0704

0.1048

0.2361

0.481

Q9UNH5

CDC14A

Dual specificity protein phosphatase CDC14A

Predicted

0.1855

0.0109

0.259

0.3735

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P35610

SOAT1

Sterol ONoneacyltransferase 1

Predicted

0.3855

0.2936

0.0165

0.7964

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

P06737

PYGL

Glycogen phosphorylase, liver form

Predicted

0.3733

0.2211

0.3169

0.9457

P08514

ITGA2B

Integrin alphaNoneIIb

Predicted

0.0782

0.3248

0.779

1.4677

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P42892

ECE1

EndothelinNoneconverting enzyme 1

Predicted

0.4853

0.0922

0.4269

P07384

CAPN1

CalpainNone1 catalytic subunit

Predicted

0.023

0.1489

0.6038

0.9131

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P20292

ALOX5AP

Arachidonate 5NonelipoxygenaseNoneactivating protein

Predicted

0.1303

0.2418

0.0907

0.6395

O75381

PEX14

Peroxisomal membrane protein PEX14

Predicted

0.1907

0.0995

0.1097

0.4039

P51812

RPS6KA3

Ribosomal protein S6 kinase alphaNone3

Predicted

0.2865

0.3936

0.4146

1.345

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

PharmaCoNets of Conivaptan (SPCN: 299.51 )

Conivaptan regulated-network (SDN: 29.39)

Community members of Conivaptan (SDC: 10.19)

PharmaCoNets of Conivaptan (S_PCN: 299.51 )

Conivaptan regulated-network (S_DN: 29.39)

Community members of Conivaptan (S_DC: 10.19)