PharmaCoNets

PharmaCoNets of Antipyrine (S_PCN: 118.63 )

Antipyrine regulated-network (S_DN: 19.74)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Antipyrine

hsa00010

Glycolysis / Gluconeogenesis

3.34E-03

P04075, P04406, P60174, P06744

ALDOA, GAPDH, TPI1, GPI

Antipyrine

hsa00030

Pentose phosphate pathway

4.19E-02

P06744, P04075

GPI, ALDOA

Antipyrine

hsa00051

Fructose and mannose metabolism

2.90E-02

P60174, P04075

TPI1, ALDOA

Antipyrine

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Antipyrine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Antipyrine

hsa00250

Alanine, aspartate and glutamate metabolism

1.22E-02

Q96RQ9, P15104

IL4I1, GLUL

Antipyrine

hsa00270

Cysteine and methionine metabolism

3.39E-02

Q96RQ9, P40926

IL4I1, MDH2

Antipyrine

hsa00500

Starch and sucrose metabolism

8.96E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Antipyrine

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Antipyrine

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Antipyrine

hsa00561

Glycerolipid metabolism

1.12E-02

Q8NEB5, P14550, Q86XP1

PPAPDC1B, AKR1A1, DGKH

Antipyrine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Antipyrine

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Antipyrine

hsa00730

Thiamine metabolism

1.44E-03

P05186, P24666

ALPL, ACP1

Antipyrine

hsa00750

Vitamin B6 metabolism

3.56E-02

O00764

PDXK

Antipyrine

hsa00830

Retinol metabolism

1.36E-03

P00325

ADH1B

Antipyrine

hsa00900

Terpenoid backbone biosynthesis

1.22E-02

P49354, Q9UHG3

FNTA, PCYOX1

Antipyrine

hsa00970

Aminoacyl-tRNA biosynthesis

2.41E-05

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Antipyrine

hsa01200

Carbon metabolism

1.61E-02

P04075, P04406, P06744, P60174

ALDOA, GAPDH, GPI, TPI1

Antipyrine

hsa01210

2-Oxocarboxylic acid metabolism

3.56E-02

P50213

IDH3A

Antipyrine

hsa01230

Biosynthesis of amino acids

1.60E-02

P60174, P04406, P04075

TPI1, GAPDH, ALDOA

Antipyrine

hsa01524

Platinum drug resistance

4.78E-02

P31751

AKT2

Antipyrine

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Antipyrine

hsa03008

Ribosome biogenesis in eukaryotes

2.99E-02

P78345, Q9BVP2

RPP38, GNL3

Antipyrine

hsa03013

RNA transport

4.92E-03

P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Antipyrine

hsa03015

mRNA surveillance pathway

1.83E-02

Q13362, Q14738, Q9UBU9

PPP2R5C, PPP2R5D, NXF1

Antipyrine

hsa03020

RNA polymerase

5.03E-06

P24928, P62487, Q9GZM3, P52435

POLR2A, POLR2G, POLR2J2, POLR2J

Antipyrine

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Antipyrine

hsa03050

Proteasome

1.53E-03

P55036

PSMD4

Antipyrine

hsa03410

Base excision repair

2.90E-02

P49005, P29372

POLD2, MPG

Antipyrine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Antipyrine

hsa04012

ErbB signaling pathway

1.91E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Antipyrine

hsa04014

Ras signaling pathway

4.37E-03

P31751, P42338, P20827, P49767, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174

AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1

Antipyrine

hsa04015

Rap1 signaling pathway

2.75E-03

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P31751, P0DP23, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1

Antipyrine

hsa04020

Calcium signaling pathway

2.41E-02

Q96DU7, Q13557, P21860, P26678, P63092

ITPKC, CAMK2D, ERBB3, PLN, GNAS

Antipyrine

hsa04022

cGMP-PKG signaling pathway

5.07E-03

P31751, P0DP23

AKT2, CALM1

Antipyrine

hsa04024

cAMP signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Antipyrine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

2.91E-02

P09341, P25024, P25025, P47992, Q9UBD3, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNF

Antipyrine

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Antipyrine

hsa04064

NF-kappa B signaling pathway

1.91E-04

P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A

Antipyrine

hsa04071

Sphingolipid signaling pathway

5.94E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Antipyrine

hsa04080

Neuroactive ligand-receptor interaction

3.11E-04

P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADM

Antipyrine

hsa04110

Cell cycle

2.06E-02

Q9UBD5, P06493, Q14683, P30304, P33981, P01106

ORC3, CDK1, SMC1A, CDC25A, TTK, MYC

Antipyrine

hsa04114

Oocyte meiosis

1.25E-03

P51812, Q02750, P0DP23, P16298, Q17RY0, Q13362, Q14738

RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, PPP2R5C, PPP2R5D

Antipyrine

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Antipyrine

hsa04145

Phagosome

3.63E-03

Q15080, P14598, Q71U36, Q13509, Q13885, Q13488, P05164, O60603, P35443, P13765, P01889, P10321

NCF4, NCF1, TUBA1A, TUBB3, TUBB2A, TCIRG1, MPO, TLR2, THBS4, HLA-DOB, HLA-B, HLA-C

Antipyrine

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Antipyrine

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Antipyrine

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Antipyrine

hsa04152

AMPK signaling pathway

1.83E-02

Q96RR4, Q13362, Q14738

CAMKK2, PPP2R5C, PPP2R5D

Antipyrine

hsa04210

Apoptosis

1.52E-02

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1

Antipyrine

hsa04218

Cellular senescence

5.03E-04

P31751, P0DP23, P01889, P10321, P05141, P12236

AKT2, CALM1, HLA-B, HLA-C, SLC25A5, SLC25A6

Antipyrine

hsa04261

Adrenergic signaling in cardiomyocytes

1.74E-03

P31751, Q13362, Q14738, P0DP23

AKT2, PPP2R5C, PPP2R5D, CALM1

Antipyrine

hsa04330

Notch signaling pathway

1.12E-02

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Antipyrine

hsa04360

Axon guidance

2.88E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Antipyrine

hsa04370

VEGF signaling pathway

3.03E-04

P16298, P31751, Q05397, Q02750

PPP3CB, AKT2, PTK2, MAP2K1

Antipyrine

hsa04371

Apelin signaling pathway

9.78E-04

P63218, P50151, Q8WYR1, P31751, Q14814, Q14344, Q13485, P84022, P0DP23

GNG5, GNG10, PIK3R5, AKT2, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Antipyrine

hsa04380

Osteoclast differentiation

2.72E-04

Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2

Antipyrine

hsa04390

Hippo signaling pathway

2.30E-02

P63261, P04628, O43623

ACTG1, WNT1, SNAI2

Antipyrine

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.96E-02

P04628, P40189, P14653

WNT1, IL6ST, HOXB1

Antipyrine

hsa04610

Complement and coagulation cascades

1.29E-05

P00734, P0C0L4

F2, C4A

Antipyrine

hsa04612

Antigen processing and presentation

1.03E-02

P48382, P26715, P26717, Q13241, O43908, P01732, P01375

RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Antipyrine

hsa04613

Neutrophil extracellular trap formation

1.28E-06

P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P05164	MPO	Myeloperoxidase	0.717
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.736
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13547	HDAC1	Histone deacetylase 1	-0.759
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.706
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.923
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.779
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43315	AQP9	Aquaporin-9	0.918
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Antipyrine

hsa04620

Toll-like receptor signaling pathway

4.78E-02

P31751

AKT2

Antipyrine

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Antipyrine

hsa04622

RIG-I-like receptor signaling pathway

3.02E-03

Q9NQC7, Q12933, P10145

CYLD, TRAF2, IL8

Antipyrine

hsa04625

C-type lectin receptor signaling pathway

2.27E-04

Q9ULY5, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Antipyrine

hsa04630

JAK-STAT signaling pathway

4.43E-02

P48551, P40189, Q06124

IFNAR2, IL6ST, PTPN11

Antipyrine

hsa04650

Natural killer cell mediated cytotoxicity

6.72E-06

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P78314	SH3BP2	SH3 domain-binding protein 2	0.718
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.786
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.764
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.707
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P60174	TPI1	Triosephosphate isomerase	Q29983	MICA	MHC class I polypeptide-related sequence A	0.701
P60174	TPI1	Triosephosphate isomerase	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.701
P60174	TPI1	Triosephosphate isomerase	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.701
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.719
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.773
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.803
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Antipyrine

hsa04657

IL-17 signaling pathway

1.63E-04

O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF

Antipyrine

hsa04658

Th1 and Th2 cell differentiation

9.73E-03

P20963, P09693, Q16539, P06239, Q9UL17, P13765

CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOB

Antipyrine

hsa04659

Th17 cell differentiation

4.08E-04

Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P09693, P20963

MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Antipyrine

hsa04660

T cell receptor signaling pathway

4.20E-02

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK

Antipyrine

hsa04662

B cell receptor signaling pathway

3.64E-03

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Antipyrine

hsa04664

Fc epsilon RI signaling pathway

7.42E-04

P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Antipyrine

hsa04668

TNF signaling pathway

1.83E-03

P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9

Antipyrine

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Antipyrine

hsa04713

Circadian entrainment

1.75E-02

Q13557, Q02153, P61952, P63092

CAMK2D, GUCY1B3, GNG11, GNAS

Antipyrine

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Antipyrine

hsa04722

Neurotrophin signaling pathway

2.83E-03

P31751, P0DP23

AKT2, CALM1

Antipyrine

hsa04728

Dopaminergic synapse

1.07E-04

P63092, P61952, P31751, Q99941, Q13557, Q13362, Q14738, P0DP23, O15516

GNAS, GNG11, AKT2, CREBL1, CAMK2D, PPP2R5C, PPP2R5D, CALM1, CLOCK

Antipyrine

hsa04740

Olfactory transduction

2.41E-02

P0DP23

CALM1

Antipyrine

hsa04744

Phototransduction

1.81E-02

P0DP23

CALM1

Antipyrine

hsa04910

Insulin signaling pathway

9.82E-04

P0DP23, P31751

CALM1, AKT2

Antipyrine

hsa04911

Insulin secretion

4.88E-02

P63092, Q99941, Q13557

GNAS, CREBL1, CAMK2D

Antipyrine

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Antipyrine

hsa04915

Estrogen signaling pathway

5.07E-03

P31751, P0DP23

AKT2, CALM1

Antipyrine

hsa04916

Melanogenesis

4.78E-02

P0DP23

CALM1

Antipyrine

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Antipyrine

hsa04920

Adipocytokine signaling pathway

1.22E-02

P25963, P33121, Q04759, P31751, P01375

NFKBIA, ACSL1, PRKCQ, AKT2, TNF

Antipyrine

hsa04921

Oxytocin signaling pathway

3.13E-02

P0DP23, Q96RR4, Q13469

CALM1, CAMKK2, NFATC2

Antipyrine

hsa04922

Glucagon signaling pathway

1.79E-03

P31751, P0DP23

AKT2, CALM1

Antipyrine

hsa04923

Regulation of lipolysis in adipocytes

3.01E-02

P31751

AKT2

Antipyrine

hsa04924

Renin secretion

3.01E-02

P0DP23

CALM1

Antipyrine

hsa04929

GnRH secretion

1.81E-02

P31751

AKT2

Antipyrine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Antipyrine

hsa04934

Cushing syndrome

1.75E-02

Q99941, P63092, O15169, Q13557

CREBL1, GNAS, AXIN1, CAMK2D

Antipyrine

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Antipyrine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Antipyrine

hsa04970

Salivary secretion

1.22E-02

P22694, Q14643, P17252, P0DP23, P49913

PRKACB, ITPR1, PRKCA, CALM1, CAMP

Antipyrine

hsa04971

Gastric acid secretion

4.78E-02

P0DP23

CALM1

Antipyrine

hsa04972

Pancreatic secretion

1.31E-02

Q08828, P62491

ADCY1, RAB11A

Antipyrine

hsa04973

Carbohydrate digestion and absorption

2.41E-02

P31751

AKT2

Antipyrine

hsa04976

Bile secretion

3.87E-02

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Antipyrine

hsa04979

Cholesterol metabolism

1.61E-02

P38571, P61916

LIPA, NPC2

Antipyrine

hsa05010

Alzheimer disease

2.44E-05

Q00535, P0DP23, P04406, P18848, Q71U36, Q13885, P67870, P31751, P05141, P12236, P43686

CDK5, CALM1, GAPDH, ATF4, TUBA1A, TUBB2A, CSNK2B, AKT2, SLC25A5, SLC25A6, PSMC4

Antipyrine

hsa05012

Parkinson disease

8.59E-03

P05141, P12236, P18848, P43686, Q71U36, Q13885

SLC25A5, SLC25A6, ATF4, PSMC4, TUBA1A, TUBB2A

Antipyrine

hsa05014

Amyotrophic lateral sclerosis

2.47E-02

P20333, P18848, Q71U36, Q13885, P43686, P51991

TNFRSF1B, ATF4, TUBA1A, TUBB2A, PSMC4, HNRPA3

Antipyrine

hsa05016

Huntington disease

1.30E-03

Q9GZM3, P52435, P05141, P12236, Q71U36, Q13885, P43686, P55036

POLR2J2, POLR2J, SLC25A5, SLC25A6, TUBA1A, TUBB2A, PSMC4, PSMD4

Antipyrine

hsa05020

Prion disease

5.51E-03

P18848, P05141, P12236, P43686, Q71U36, Q13885, P67870

ATF4, SLC25A5, SLC25A6, PSMC4, TUBA1A, TUBB2A, CSNK2B

Antipyrine

hsa05022

Pathways of neurodegeneration - multiple diseases

6.47E-04

Q71U36, Q13885, P67870, P18848, P05141, P12236, P20333, Q00535, P0DP23, P43686

TUBA1A, TUBB2A, CSNK2B, ATF4, SLC25A5, SLC25A6, TNFRSF1B, CDK5, CALM1, PSMC4

Antipyrine

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Antipyrine

hsa05031

Amphetamine addiction

1.00E-02

P0DP23, Q13557, P63092, Q99941

CALM1, CAMK2D, GNAS, CREBL1

Antipyrine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.87E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Antipyrine

hsa05130

Pathogenic Escherichia coli infection

1.11E-02

Q71U36, P19338, Q13885, P04406, P23396

TUBA1A, NCL, TUBB2A, GAPDH, RPS3

Antipyrine

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Antipyrine

hsa05132

Salmonella infection

5.49E-03

P51617, P25963, P01375, P23396, Q9UJU2, Q13489, P10415, P04406, Q96A32, O60603, Q9BQS8, Q8IWE5, Q13561, Q71U36, Q13509, Q13885

IRAK1, NFKBIA, TNF, RPS3, LEF1, BIRC3, BCL2, GAPDH, MYLPF, TLR2, FYCO1, PLEKHM2, DCTN2, TUBA1A, TUBB3, TUBB2A

Antipyrine

hsa05133

Pertussis

2.64E-03

P0DP23, P0C0L4

CALM1, C4A

Antipyrine

hsa05140

Leishmaniasis

1.59E-03

O75015, P14598, P13765, O60603, P25963, P01375, Q16539, P51617, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MAPK14, IRAK1, NCF4

Antipyrine

hsa05143

African trypanosomiasis

1.74E-03

P69905, P68871

HBA2, HBB

Antipyrine

hsa05144

Malaria

1.16E-04

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Antipyrine

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Antipyrine

hsa05146

Amoebiasis

9.31E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Antipyrine

hsa05152

Tuberculosis

7.36E-03

Q13488, P0DP23, P48382, O60603, P01375, P31751, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Antipyrine

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Antipyrine

hsa05163

Human cytomegalovirus infection

8.39E-03

P31751, P01375, P0DP23, P49841, P14778, P25025, Q16539, O00463

AKT2, TNF, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Antipyrine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.44E-04

P31751, P23458, P62879, Q13469, P16298, Q02750, P0DP23, P0CG47

AKT2, JAK1, GNB2, NFATC2, PPP3CB, MAP2K1, CALM1, UBB

Antipyrine

hsa05169

Epstein-Barr virus infection

4.41E-02

P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247

Antipyrine

hsa05170

Human immunodeficiency virus 1 infection

2.86E-07

P31751, Q02750, P01889, P10321, P62879, P16298, P0DP23, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, Q9NQU5, P10415, Q13619, Q93034, Q9Y6Q5, P20333

AKT2, MAP2K1, HLA-B, HLA-C, GNB2, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PAK6, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P60174	TPI1	Triosephosphate isomerase	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.701
P60174	TPI1	Triosephosphate isomerase	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.701
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
P60174	TPI1	Triosephosphate isomerase	Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	0.778
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811
P60174	TPI1	Triosephosphate isomerase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.752
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Antipyrine

hsa05200

Pathways in cancer

1.81E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P31751, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, AKT2, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Antipyrine

hsa05202

Transcriptional misregulation in cancer

7.86E-06

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Antipyrine

hsa05211

Renal cell carcinoma

4.78E-02

P31751

AKT2

Antipyrine

hsa05212

Pancreatic cancer

1.26E-03

P42338, P31751, Q15311, P23458, P84022, Q13485, O75293

PIK3CB, AKT2, RALBP1, JAK1, SMAD3, SMAD4, GADD45B

Antipyrine

hsa05213

Endometrial cancer

4.72E-03

O15169, P31751, Q02750

AXIN1, AKT2, MAP2K1

Antipyrine

hsa05214

Glioma

5.75E-04

P0DP23, P31751

CALM1, AKT2

Antipyrine

hsa05218

Melanoma

3.01E-02

P31751

AKT2

Antipyrine

hsa05220

Chronic myeloid leukemia

3.64E-03

Q13547, Q13485, P84022, P31751, P42338, O75293

HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, GADD45B

Antipyrine

hsa05221

Acute myeloid leukemia

4.19E-02

P31751

AKT2

Antipyrine

hsa05222

Small cell lung cancer

5.10E-03

P31751, Q13489, P10415, P25963, Q13077, O00463, P24522

AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Antipyrine

hsa05223

Non-small cell lung cancer

2.41E-02

P31751

AKT2

Antipyrine

hsa05226

Gastric cancer

4.72E-03

Q02750, P31751, O15169

MAP2K1, AKT2, AXIN1

Antipyrine

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Antipyrine

hsa05231

Choline metabolism in cancer

2.60E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Antipyrine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.03E-02

P20963, P09693, P06239, O60603, Q16539

CD247, CD3G, LCK, TLR2, MAPK14

Antipyrine

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Antipyrine

hsa05321

Inflammatory bowel disease

1.28E-02

O60603, P01375, P13765, Q14765, P23771

TLR2, TNF, HLA-DOB, STAT4, GATA3

Antipyrine

hsa05322

Systemic lupus erythematosus

4.20E-02

P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455

ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB

Antipyrine

hsa05332

Graft-versus-host disease

9.30E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Antipyrine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Antipyrine

hsa05416

Viral myocarditis

2.30E-02

P10747, P63261

CD28, ACTG1

Antipyrine

hsa05418

Fluid shear stress and atherosclerosis

3.33E-05

Q16539, P31751, Q14145, P10599, P14780, P01375, P14778, P27930, P0DP23

MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1

Community members of Antipyrine (S_DC: 6.01)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Predicted

0.2958

0.3134

0.7747

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

Q16769

QPCT

GlutaminylNonepeptide cyclotransferase

Predicted

0.0245

0.2416

0.4954

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

Q6PL18

ATAD2

ATPase family AAA domainNonecontaining protein 2

Predicted

0.1963

0.0512

0.2006

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P98170

BIRC4

E3 ubiquitinNoneprotein ligase XIAP

Predicted

0.2974

0.2298

0.79

1.3984

P07384

CAPN1

CalpainNone1 catalytic subunit

Predicted

0.023

0.1489

0.6038

0.9131

P60174

TPI1

Triosephosphate isomerase

Predicted

0.2669

0.0121

0.2901

0.4478

Q9Y2I1

NISCH

Nischarin

Predicted

0.6082

0.2251

0.7543

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

PharmaCoNets of Antipyrine (SPCN: 118.63 )

Antipyrine regulated-network (SDN: 19.74)

Community members of Antipyrine (SDC: 6.01)

PharmaCoNets of Antipyrine (S_PCN: 118.63 )

Antipyrine regulated-network (S_DN: 19.74)

Community members of Antipyrine (S_DC: 6.01)