PharmaCoNets of Alpelisib (SPCN: 38.06 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alpelisibhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Alpelisibhsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Alpelisibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Alpelisibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Alpelisibhsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Alpelisibhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Alpelisibhsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Alpelisibhsa00785Lipoic acid metabolism4.57E-021Q9Y234LIPT1More
Alpelisibhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Alpelisibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Alpelisibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Alpelisibhsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Alpelisibhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Alpelisibhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Alpelisibhsa01522Endocrine resistance4.48E-024P22694, Q02750, Q9UM47, P46527PRKACB, MAP2K1, NOTCH3, CDKN1BMore
Alpelisibhsa01523Antifolate resistance2.04E-022P04818, P18054TYMS, ALOX12More
Alpelisibhsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Alpelisibhsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Alpelisibhsa03450Non-homologous end-joining4.48E-031P78527PRKDCMore
Alpelisibhsa04014Ras signaling pathway4.04E-026Q02750, Q15389, P17252, P21359, P62879, P22694MAP2K1, ANGPT1, PRKCA, NF1, GNB2, PRKACBMore
Alpelisibhsa04061Viral protein interaction with cytokine and cytokine receptor3.02E-023P09341, P02775, Q13651CXCL1, PPBP, IL10RAMore
Alpelisibhsa04064NF-kappa B signaling pathway1.01E-0312O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CYLDMore
Alpelisibhsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Alpelisibhsa04110Cell cycle1.35E-021P78527PRKDCMore
Alpelisibhsa04114Oocyte meiosis3.27E-023Q9UJX4, P30260, Q16539ANAPC5, CDC27, MAPK14More
Alpelisibhsa04210Apoptosis4.31E-024P04637, P24522, P43234, P42575TP53, GADD45A, CTSO, CASP2More
Alpelisibhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Alpelisibhsa04530Tight junction2.45E-036Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Alpelisibhsa04540Gap junction2.03E-024P17252, P22694, P68371, Q02750PRKCA, PRKACB, TUBB2C, MAP2K1More
Alpelisibhsa04613Neutrophil extracellular trap formation4.05E-0318O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Alpelisibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Alpelisibhsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Alpelisibhsa04640Hematopoietic cell lineage4.31E-0210P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNF, IL1BMore
Alpelisibhsa04650Natural killer cell mediated cytotoxicity2.99E-0210P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Alpelisibhsa04657IL-17 signaling pathway2.25E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Alpelisibhsa04658Th1 and Th2 cell differentiation1.26E-0210Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, P23458PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1More
Alpelisibhsa04659Th17 cell differentiation1.39E-0211Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P01584, P09693, P20963, P23458PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3G, CD247, JAK1More
Alpelisibhsa04660T cell receptor signaling pathway1.11E-0211P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Alpelisibhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Alpelisibhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Alpelisibhsa04720Long-term potentiation1.09E-024P17252, P51812, P22694, Q02750PRKCA, RPS6KA3, PRKACB, MAP2K1More
Alpelisibhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Alpelisibhsa04725Cholinergic synapse2.59E-037P22694, P17252, P62879, P63218, P50151, P42338, Q02750PRKACB, PRKCA, GNB2, GNG5, GNG10, PIK3CB, MAP2K1More
Alpelisibhsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Alpelisibhsa04727GABAergic synapse1.08E-037P62879, P63218, P50151, P15104, P22694, O60296, P17252GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCAMore
Alpelisibhsa04750Inflammatory mediator regulation of TRP channels1.17E-028P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2More
Alpelisibhsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Alpelisibhsa04914Progesterone-mediated oocyte maturation1.46E-023Q9UJX4, P30260, Q16539ANAPC5, CDC27, MAPK14More
Alpelisibhsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Alpelisibhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Alpelisibhsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Alpelisibhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Alpelisibhsa04970Salivary secretion4.22E-023P22694, P17252, P49913PRKACB, PRKCA, CAMPMore
Alpelisibhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alpelisibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Alpelisibhsa05140Leishmaniasis1.93E-0310P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Alpelisibhsa05144Malaria2.43E-026P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Alpelisibhsa05146Amoebiasis5.82E-039P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Alpelisibhsa05160Hepatitis C4.55E-023O00501, P29728, P01106CLDN5, OAS2, MYCMore
Alpelisibhsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Alpelisibhsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Alpelisibhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Alpelisibhsa05202Transcriptional misregulation in cancer9.53E-0419Q12778, Q13315, P17844, P14780, P27930, Q15744, Q16548, Q13077, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Alpelisibhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Alpelisibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Alpelisibhsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Alpelisibhsa05216Thyroid cancer2.72E-022P04637, P24522TP53, GADD45AMore
Alpelisibhsa05217Basal cell carcinoma8.24E-035Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Alpelisibhsa05218Melanoma2.72E-022P04637, P24522TP53, GADD45AMore
Alpelisibhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Alpelisibhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Alpelisibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.71E-039O95267, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730RASGRP1, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Alpelisibhsa05321Inflammatory bowel disease1.21E-027O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Alpelisibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alpelisibhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Alpelisib (SDC: 4.24)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04637TP53Cellular tumor antigen p53Predicted10.10040.041711.1336
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)