PharmaCoNets of Ademetionine (SPCN: 28.14 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ademetioninehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Ademetioninehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Ademetioninehsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Ademetioninehsa00220Arginine biosynthesis4.88E-021P49448GLUD2More
Ademetioninehsa00230Purine metabolism3.95E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Ademetioninehsa00240Pyrimidine metabolism2.84E-022Q7LG56, Q9Y227RRM2B, ENTPD4More
Ademetioninehsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Ademetioninehsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Ademetioninehsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Ademetioninehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Ademetioninehsa00630Glyoxylate and dicarboxylate metabolism6.94E-032P40925, P15104MDH1, GLULMore
Ademetioninehsa00900Terpenoid backbone biosynthesis2.64E-021P49354FNTAMore
Ademetioninehsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Ademetioninehsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Ademetioninehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Ademetioninehsa03013RNA transport1.70E-0618O14980, P52298, Q09161, O14893, P61326, Q15287, Q7Z3B4, P35658, P47813, Q14152, O15371, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NUP54, NUP214, EIF1AX, EIF3A, EIF3D, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1More
Ademetioninehsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Ademetioninehsa03040Spliceosome4.87E-037O43143, P08579, P26368, Q13595, Q07955, P84103, Q13243DHX15, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS3, SFRS5More
Ademetioninehsa03060Protein export6.73E-043Q15070, P37108, Q15005OXA1L, SRP14, SPCS2More
Ademetioninehsa04062Chemokine signaling pathway3.81E-026P07948, P62873, P63218, P50151, P43250, Q13009LYN, GNB1, GNG5, GNG10, GRK6, TIAM1More
Ademetioninehsa04064NF-kappa B signaling pathway3.22E-046Q13489, Q13546, P01584, Q9UDY8, P10145, Q9UNE0BIRC3, RIPK1, IL1B, MALT1, IL8, EDARMore
Ademetioninehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Ademetioninehsa04146Peroxisome2.92E-036O43933, O96011, P56589, Q9UKG9, O75521, P33121PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1More
Ademetioninehsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Ademetioninehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Ademetioninehsa04217Necroptosis1.33E-037P01568, Q13489, P98170, Q13546, P08238, P15104, P21796IFNA21, BIRC3, BIRC4, RIPK1, HSP90AB1, GLUL, VDAC1More
Ademetioninehsa04371Apelin signaling pathway3.23E-047P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1More
Ademetioninehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Ademetioninehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ademetioninehsa04620Toll-like receptor signaling pathway1.18E-034Q13546, P01568, P10145, P01584RIPK1, IFNA21, IL8, IL1BMore
Ademetioninehsa04621NOD-like receptor signaling pathway4.70E-035P01584, P01568, Q13489, Q13546, P10145IL1B, IFNA21, BIRC3, RIPK1, IL8More
Ademetioninehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Ademetioninehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Ademetioninehsa04640Hematopoietic cell lineage4.24E-022P04234, P01584CD3D, IL1BMore
Ademetioninehsa04657IL-17 signaling pathway1.61E-038O00463, Q16539, P14780, Q9UJX4, P10145, P80188, P01375, P01584TRAF5, MAPK14, MMP9, ANAPC5, IL8, LCN2, TNF, IL1BMore
Ademetioninehsa04658Th1 and Th2 cell differentiation4.75E-022P04234, Q13761CD3D, RUNX3More
Ademetioninehsa04659Th17 cell differentiation4.24E-022P01584, P04234IL1B, CD3DMore
Ademetioninehsa04713Circadian entrainment1.78E-035O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Ademetioninehsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Ademetioninehsa04724Glutamatergic synapse1.11E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Ademetioninehsa04725Cholinergic synapse9.51E-034P62873, P63218, P50151, Q16566GNB1, GNG5, GNG10, CAMK4More
Ademetioninehsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Ademetioninehsa04727GABAergic synapse2.45E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Ademetioninehsa04744Phototransduction6.94E-032P62873, P0DP23GNB1, CALM1More
Ademetioninehsa04918Thyroid hormone synthesis3.95E-023P51828, P02768, P05543ADCY7, ALB, SERPINA7More
Ademetioninehsa04932Non-alcoholic fatty liver disease4.75E-022P10145, P01584IL8, IL1BMore
Ademetioninehsa04933AGE-RAGE signaling pathway in diabetic complications1.39E-022P01584, P10145IL1B, IL8More
Ademetioninehsa04964Proximal tubule bicarbonate reclamation4.53E-032P00918, P49448CA2, GLUD2More
Ademetioninehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Ademetioninehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Ademetioninehsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Ademetioninehsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Ademetioninehsa05034Alcoholism3.87E-037O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93079GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, H2BC9More
Ademetioninehsa05131Shigellosis2.01E-023P01584, P10145, Q14141IL1B, IL8, SEPT6More
Ademetioninehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Ademetioninehsa05133Pertussis1.31E-033P01584, P10145, P0C0L4IL1B, IL8, C4AMore
Ademetioninehsa05134Legionellosis8.42E-043P01584, P68104, P10145IL1B, EEF1A1, IL8More
Ademetioninehsa05140Leishmaniasis3.76E-022P01584, P68104IL1B, EEF1A1More
Ademetioninehsa05142Chagas disease1.14E-033P01584, P10145, P04234IL1B, IL8, CD3DMore
Ademetioninehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Ademetioninehsa05144Malaria1.01E-034P69905, P68871, P01584, P10145HBA2, HBB, IL1B, IL8More
Ademetioninehsa05146Amoebiasis4.75E-022P01584, P10145IL1B, IL8More
Ademetioninehsa05150Staphylococcus aureus infection2.81E-046P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Ademetioninehsa05162Measles3.76E-022P04234, P01584CD3D, IL1BMore
Ademetioninehsa05163Human cytomegalovirus infection2.00E-026P62873, P63218, P50151, P0DP23, P30101, P01568GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21More
Ademetioninehsa05167Kaposi sarcoma-associated herpesvirus infection2.00E-026P01568, P62873, P63218, P50151, P07948, P0DP23IFNA21, GNB1, GNG5, GNG10, LYN, CALM1More
Ademetioninehsa05168Herpes simplex virus 1 infection4.43E-028P01568, Q07955, P84103, Q13243, Q13489, P30101, Q13398, Q9NZL3IFNA21, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF224More
Ademetioninehsa05170Human immunodeficiency virus 1 infection1.83E-027P62873, P63218, P50151, P0DP23, P30101, P01568, P23528GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, CFL1More
Ademetioninehsa05200Pathways in cancer3.99E-0415Q13751, P08238, P43246, P84022, Q13485, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P01042LAMB3, HSP90AB1, MSH2, SMAD3, SMAD4, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, KNG1More
Ademetioninehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Ademetioninehsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Ademetioninehsa05212Pancreatic cancer3.28E-023P84022, Q13485, O75293SMAD3, SMAD4, GADD45BMore
Ademetioninehsa05214Glioma3.28E-023P0DP23, Q16566, O75293CALM1, CAMK4, GADD45BMore
Ademetioninehsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Ademetioninehsa05323Rheumatoid arthritis3.76E-022P01584, P10145IL1B, IL8More
Ademetioninehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Ademetionine (SDC: 3.00)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P17707AMD1SNoneadenosylmethionine decarboxylase proenzymeReported00.80270.05050.16450.6667
Q9HBK9AS3MTArsenite methyltransferaseReported00.41110.006700.2189
P26358DNMT1DNAPredicted00.34040.28090.26590.998
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P22061PCMT1ProteinNoneLNoneisoaspartate(DNoneaspartate) ONonemethyltransferasePredicted00.26260.005600.1426
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)