• Score Type:
• Meta Z-score
• Z-score
• No. of Genes

HisBIM: A Hierarchical System Biology Model

System/Subsystem/Pathway	Z-score
	CH-CN up	CH-CN down	CJ-CH up	CJ-CH down
	499/1135	520/1185	777/1826	566/1235
+ 1. Metabolism	7.6	7.6	9.8	9.6
+ 1.0 Global and overview maps	4.8	4.5	5.6	6.4
+ 01100: Metabolic pathways	2.8	2.9	3.4	3.3
KYAT1	V			V
CRLS1	V
PLD3	V
HSD17B4	V			V
ELOVL6	V
GLYCTK	V
SHMT2	V	V	V	V
GSTT1	V	V	V	V
GSTK1	V
MGST2	V			V
GSR	V	V		V
ALDH3A2	V	V	V	V
AOC3	V
INPPL1	V			V
PIP5K1A	V		V
SYNJ2	V			V
PIP4K2C	V	V	V	V
PIP4K2B	V			V
INPP5A	V
IMPA1	V	V		V
ACADM	V	V
ALAS1	V
LDHA	V	V		V
BCAT1	V	V	V
UPP1	V			V
NT5C3A	V
FHIT	V
NME2	V		V	V
NME1-NME2	V		V	V
NME4	V
PKM	V	V
IMPDH1	V	V
NUDT9	V			V
MDH1	V		V
MIOX	V			V
PFKFB3	V		V	V
ACACA	V			V
GPI	V
PDHA1	V	V	V	V
PDHB	V		V
B4GALT2	V			V
GALT	V
NFS1	V
AK4	V
AKR1B1	V
LPIN2	V
FDFT1	V	V	V
UAP1L1	V			V
DCXR	V
GNPDA1	V
GFPT1	V
GNE	V		V	V
FCSK	V
ALDH5A1	V
MAT1A	V			V
AMD1	V		V
DNMT3A	V
CKB	V
CKMT1B	V			V
CKMT1A	V			V
GSTZ1	V		V
ADH6	V
IVD	V	V	V
ACADVL	V			V
ACSL1	V	V	V	V
ACSL5	V			V
BDH1	V		V	V
LSS	V
DHCR7	V	V		V
AKR1C3	V			V
TKT	V			V
GPT2	V			V
CTPS1	V	V	V	V
SELENOI	V
PTDSS2	V			V
ETNK2	V			V
CERS2	V	V	V	V
CERS4	V
SMPD4	V			V
SPTLC1	V
PTGES3	V	V	V	V
FDPS	V	V		V
RPN2	V			V
B4GALT4	V
B4GALNT1	V
SPHK2	V	V	V
SPHK1	V
ENO3	V	V
PCK2	V	V		V
IDH1	V		V	V
OGDH	V	V
DHRS4	V	V	V
HYAL1	V
PIGT	V	V	V	V
QDPR	V		V
AK6	V	V	V	V
DGUOK	V
ISYNA1	V			V
ECHDC1	V		V
PYCR1	V	V		V
HMGCR	V			V
ATP5F1A	V		V
ATP6V0B	V		V	V
ATP6V0A1	V
NDUFA11	V			V
NDUFS7	V			V
NDUFB3	V		V	V
ELOVL5		V	V	V
ALDOA		V	V
RRM2		V	V
GSTM4		V	V
MGST1		V	V
GPX1		V
MARS		V
MTR		V
G6PC		V
PIK3CB		V
PIK3C2B		V
PIK3C3		V	V
MTMR3		V
IPMK		V
ITPK1		V	V
TYMP		V
NT5C3B		V
PDE4D		V
ITPA		V	V	V
CANT1		V	V
ENTPD6		V		V
ENTPD4		V	V
DPM3		V	V
HADHB		V	V
GGCT		V
GAA		V		V
HMOX2		V	V	V
B4GALT3		V
B4GALNT3		V
GCLC		V
SMS		V
AK2		V	V
CHDH		V		V
DGKD		V
PAPSS2		V
CYP7A1		V	V
ASS1		V
MAT2A		V	V
SAT2		V
FTCD		V	V
HAL		V
AUH		V
PPT2		V
HMGCL		V
CYP51A1		V	V
NSDHL		V	V
AKR1D1		V
AMACR		V	V
GAPDH		V	V
RPE		V
UCK2		V
CHKA		V
CHKB		V
AGK		V
LPCAT1		V	V
PRXL2B		V
LIPC		V	V
PNPLA2		V	V
DGAT1		V	V
MAN2A2		V
PANK4		V
PPCS		V	V
PC		V
AGMAT		V	V
TPI1		V
GART		V	V
SGSH		V
HGSNAT		V
ACOT2		V
DHRS3		V
ARSB		V
HYAL3		V	V
AHCYL1		V
NMRK1		V
ODC1		V		V
ACY1		V
PIGW		V	V
DHFR		V	V
ACP2		V	V
RFK		V
ATP5MC2		V
ATP5PF		V
NDUFC1		V	V
NDUFS2		V	V	V
EHHADH			V
PLD1			V
SCP2			V	V
TKFC			V
SHMT1			V
MTHFR			V
GLB1			V	V
RRM1			V
NAT8			V
GPX7			V
DGLUCY			V
GLS2			V
ALDH3B1			V
PGM1			V
G6PC3			V
SACM1L			V
PI4K2B			V
PIK3C2A			V
PLCG1			V
AADAT			V
KYNU			V
AFMID			V
DDC			V
CNDP2			V
SDSL			V
GSS			V
UROS			V
UGT2B10			V
ENPP3			V
NT5C			V
NT5E			V
DTYMK			V
ADCY7			V
AK9			V
NME1			V
IMPDH2			V
PAICS			V
MDH2			V
ACSS1			V	V
KHK			V
ELOVL1			V	V
BLVRA			V
PCYT1B			V
CHST10			V
B4GALNT4			V
IDS			V
SRR			V
LIPT2			V
HMGCS2			V
LPIN3			V
CBSL			V	V
CBS			V	V
HIBCH			V
ACAD8			V
COMT			V	V
BTD			V
MAT2B			V
CDO1			V
GCDH			V
DLST			V
ASL			V	V
CPS1			V
UROC1			V
MCCC1			V
ACSBG1			V
PPT1			V
TM7SF2			V
HSD3B7			V
ACOX2			V
UCK1			V
AGPAT1			V
AGPS			V
SPTLC3			V
EPHX2			V
CBR1			V
NMNAT1			V
NADK2			V	V
MGLL			V
ALG8			V
ST6GAL1			V
COASY			V
HLCS			V
ACYP2			V
ADPGK			V
DUT			V
PRPS1			V	V
SUCLG2			V
TRAK2			V
ABHD14A-ACY1			V
PIGV			V
PIGF			V
PIGO			V
VKORC1L1			V
DHFR2			V
G6PD			V
PRUNE1			V
SUOX			V
COX11			V
ATP5MC3			V
ATP5MF			V
NDUFA2			V
NDUFA7			V
NDUFB2			V
NDUFA12			V
ARG2				V
ACSF3				V
KYAT3				V
HACD1				V
ACAA1				V
AGXT				V
RRM2B				V
GLUL				V
HK2				V
PLCD3				V
INPP1				V
UGT2A3				V
NT5C2				V
ADCY9				V
ENTPD2				V
ADSL				V
MPST				V
DPM1				V
MGAT4B				V
MGAT1				V
ELOVL7				V
LARGE2				V
A4GALT				V
SMOX				V
CYP24A1				V
UGP2				V
AKR1A1				V
TSTA3				V
ASNS				V
PLA2G2A				V
NADSYN1				V
IDI1				V
STT3A				V
MAN1B1				V
GALNT2				V
CHPF				V
GBA				V
ST6GALNAC4				V
ACSM2B				V
ENO2				V
GK				V
IDH3G				V
HYAL2				V
PIGS				V
PCCA				V
COX6C				V
ATP5F1C				V
ATP6V0C				V
+ 01200: Carbon metabolism	2	1.3	3.2	1.8
TKT	V			V
GPI	V
ENO3	V	V
PKM	V	V
PDHA1	V	V	V	V
PDHB	V		V
MDH1	V		V
IDH1	V		V	V
GLYCTK	V
SHMT2	V	V	V	V
OGDH	V	V
GPT2	V			V
ALDOA		V	V
GAPDH		V	V
RPE		V
TPI1		V
PC		V
ADPGK			V
G6PD			V
MDH2			V
SUCLG2			V
SHMT1			V
MTHFR			V
PRPS1			V	V
SDSL			V
TKFC			V
DLST			V
CPS1			V
ME2			V
EHHADH			V
HIBCH			V
ACSS1			V	V
HK2				V
ENO2				V
IDH3G				V
PCCA				V
AGXT				V
+ 01210: 2-Oxocarboxylic acid metabolism	1.7	1	1.7	1.6
GPT2	V			V
IDH1	V		V	V
BCAT1	V	V	V
ACY1		V
AADAT			V
ABHD14A-ACY1			V
IDH3G				V
+ 01212: Fatty acid metabolism	2	1.1	1.4	3.7
ELOVL6	V
HSD17B4	V			V
ACACA	V			V
ACSL1	V	V	V	V
ACSL5	V			V
ACADM	V	V
ACADVL	V			V
HADHB		V	V
ELOVL5		V	V	V
PPT2		V
ELOVL1			V	V
EHHADH			V
SCP2			V	V
ACSBG1			V
PPT1			V
HACD1				V
ELOVL7				V
ACAA1				V
ACSF3				V
+ 01230: Biosynthesis of amino acids	2.1	3.8	2.9	4
ENO3	V	V
PKM	V	V
TKT	V			V
BCAT1	V	V	V
SHMT2	V	V	V	V
IDH1	V		V	V
GPT2	V			V
PYCR1	V	V		V
MAT1A	V			V
TPI1		V
GAPDH		V	V
ALDOA		V	V
RPE		V
MTR		V
PC		V
ACY1		V
ASS1		V
MAT2A		V	V
PRPS1			V	V
SDSL			V
SHMT1			V
ABHD14A-ACY1			V
ASL			V	V
CPS1			V
MAT2B			V
CBSL			V	V
CBS			V	V
ENO2				V
IDH3G				V
ARG2				V
GLUL				V
ASNS				V
+ 1.1 Carbohydrate metabolism	5.4	3.1	3.8	5.4
+ 00010: Glycolysis / Gluconeogenesis	2.4	2.7	1.6	1.9
ALDH3A2	V	V	V	V
ADH6	V
PDHA1	V	V	V	V
PDHB	V		V
LDHA	V	V		V
PKM	V	V
ENO3	V	V
GPI	V
PCK2	V	V		V
ALDOA		V	V
GAPDH		V	V
TPI1		V
G6PC		V
ALDH3B1			V
PGM1			V
G6PC3			V
ACSS1			V	V
ADPGK			V
AKR1A1				V
ENO2				V
HK2				V
+ 00020: Citrate cycle (TCA cycle)	2.7	1.6	2.3	1.5
OGDH	V	V
IDH1	V		V	V
MDH1	V		V
PDHA1	V	V	V	V
PDHB	V		V
PCK2	V	V		V
PC		V
DLST			V
SUCLG2			V
MDH2			V
IDH3G				V
+ 00030: Pentose phosphate pathway	1.1	0.6	1	0.6
GPI	V
TKT	V			V
GLYCTK	V
RPE		V
ALDOA		V	V
PRPS1			V	V
G6PD			V
PGM1			V
+ 00040: Pentose and glucuronate interconversions	0.5	0.1	0	0.9
AKR1B1	V
DCXR	V
RPE		V
UGT2B10			V
UGP2				V
UGT2A3				V
AKR1A1				V
+ 00051: Fructose and mannose metabolism	1	0.5	0.9	1.4
AKR1B1	V
PFKFB3	V		V	V
FCSK	V
TPI1		V
ALDOA		V	V
KHK			V
TKFC			V
HK2				V
PFKFB4				V
TSTA3				V
+ 00052: Galactose metabolism	1.1	0.6	0.6	2
AKR1B1	V
B4GALT2	V			V
GALT	V
GAA		V		V
G6PC		V
GLB1			V	V
PGM1			V
G6PC3			V
HK2				V
UGP2				V
+ 00053: Ascorbate and aldarate metabolism	0.7	0.2	0.3	1.2
MIOX	V			V
ALDH3A2	V	V	V	V
UGT2B10			V
UGT2A3				V
+ 00500: Starch and sucrose metabolism	0.1	0.4	0.4	0.8
GPI	V
GAA		V		V
G6PC		V
ENPP3			V
PGM1			V
G6PC3			V
HK2				V
UGP2				V
+ 00520: Amino sugar and nucleotide sugar metabolism	2.3	0	0.1	1.7
UAP1L1	V			V
GNE	V		V	V
GNPDA1	V
GFPT1	V
GALT	V
FCSK	V
GPI	V
PGM1			V
HK2				V
CYB5R3				V
TSTA3				V
UGP2				V
+ 00620: Pyruvate metabolism	3.1	2.2	2.2	2.1
PDHA1	V	V	V	V
PDHB	V		V
PCK2	V	V		V
PKM	V	V
MDH1	V		V
LDHA	V	V		V
ALDH3A2	V	V	V	V
ACACA	V			V
PC		V
ME2			V
MDH2			V
ACSS1			V	V
ACYP2			V
+ 00630: Glyoxylate and dicarboxylate metabolism	1.2	0.2	1.9	2.1
MDH1	V		V
SHMT2	V	V	V	V
GLYCTK	V
AFMID			V
MDH2			V
SHMT1			V
ACSS1			V	V
PCCA				V
AGXT				V
GLUL				V
+ 00640: Propanoate metabolism	1	0.1	1.2	1.4
ACACA	V			V
ECHDC1	V		V
LDHA	V	V		V
HIBCH			V
ACSS1			V	V
EHHADH			V
SUCLG2			V
PCCA				V
+ 00650: Butanoate metabolism	0.7	0.2	0.7	0.6
BDH1	V		V	V
ALDH5A1	V
HMGCL		V
HMGCS2			V
EHHADH			V
ACSM2B				V
+ 00562: Inositol phosphate metabolism	2.2	2.1	0.8	2
PIP4K2C	V	V	V	V
PIP4K2B	V			V
SYNJ2	V			V
INPP5A	V
ISYNA1	V			V
IMPA1	V	V		V
MIOX	V			V
PIP5K1A	V		V
INPPL1	V			V
IPMK		V
ITPK1		V	V
PIK3C3		V	V
MTMR3		V
PIK3CB		V
TPI1		V
PIK3C2B		V
PI4K2B			V
PLCG1			V
PIK3C2A			V
SACM1L			V
INPP1				V
PLCD3				V
+ 1.2 Energy metabolism	0.1	0.4	1.2	0.9
+ 00190: Oxidative phosphorylation	0.2	0	0.7	0.5
NDUFB3	V		V	V
NDUFA11	V			V
NDUFS7	V			V
ATP5F1A	V		V
ATP6V0B	V		V	V
ATP6V0A1	V
NDUFC1		V	V
NDUFS2		V	V	V
ATP5MC2		V
ATP5PF		V
NDUFB2			V
NDUFA7			V
NDUFA2			V
COX11			V
NDUFA12			V
ATP5MC3			V
ATP5MF			V
LHPP			V
COX6C				V
ATP5F1C				V
ATP6V0C				V
+ 00910: Nitrogen metabolism	0	0	0.2	0.4
CPS1			V
GLUL				V
+ 00920: Sulfur metabolism	0	0.7	1.2	0.7
PAPSS2		V
SUOX			V
SELENBP1			V
MPST				V
+ 1.3 Lipid metabolism	3.4	3.5	3.4	4
+ 00061: Fatty acid biosynthesis	1.7	0.4	0.6	2.2
ACACA	V			V
ACSL1	V	V	V	V
ACSL5	V			V
ACSBG1			V
ACSF3				V
+ 00062: Fatty acid elongation	0.7	1.7	1.2	1.7
ACOT7	V
ELOVL6	V
PPT2		V
HADHB		V	V
ACOT2		V
ELOVL5		V	V	V
PPT1			V
ELOVL1			V	V
HACD1				V
ELOVL7				V
+ 00071: Fatty acid degradation	2	1.5	1.6	1.4
ACADM	V	V
ADH6	V
ACSL1	V	V	V	V
ACSL5	V			V
ACADVL	V			V
ALDH3A2	V	V	V	V
ECI1		V	V
HADHB		V	V
EHHADH			V
GCDH			V
ACSBG1			V
ACAA1				V
+ 00072: Synthesis and degradation of ketone bodies	0.7	0.7	1.2	0.7
BDH1	V		V	V
HMGCL		V
HMGCS2			V
+ 00100: Steroid biosynthesis	1.7	2.2	2.7	0.9
DHCR7	V	V		V
LSS	V
FDFT1	V	V	V
CYP51A1		V	V
NSDHL		V	V
TM7SF2			V
SOAT1			V
SOAT2			V
CYP24A1				V
+ 00120: Primary bile acid biosynthesis	0.5	2.4	2.4	1
HSD17B4	V			V
CYP7A1		V	V
AKR1D1		V
AMACR		V	V
CYP39A1		V
ACOX2			V
SCP2			V	V
HSD3B7			V
+ 00140: Steroid hormone biosynthesis	0	0.4	0.1	0.6
AKR1C3	V			V
AKR1D1		V
DHRS11		V
CYP7A1		V	V
UGT2B10			V
COMT			V	V
AKR1C1				V
UGT2A3				V
+ 00561: Glycerolipid metabolism	0.7	1.8	1.2	0.3
LPIN2	V
AKR1B1	V
ALDH3A2	V	V	V	V
GLYCTK	V
LIPC		V	V
PNPLA2		V	V
DGAT1		V	V
PLPP5		V
AGK		V
DGKD		V
LPIN3			V
AGPAT1			V
MGLL			V
TKFC			V
GK				V
AKR1A1				V
+ 00564: Glycerophospholipid metabolism	1.6	0.4	0.4	0.5
PTDSS2	V			V
ETNK2	V			V
LPIN2	V
PLD3	V
LCAT	V			V
SELENOI	V
LYPLA1	V		V	V
CRLS1	V
LPGAT1	V
LPCAT1		V	V
CHKA		V
CHKB		V
DGKD		V
PLPP5		V
PCYT1B			V
LPIN3			V
PLD1			V
AGPAT1			V
GPD1			V
MBOAT7			V
PLA2G2A				V
PLA2G15				V
+ 00565: Ether lipid metabolism	0.3	0.1	0.2	0.6
SELENOI	V
PLD3	V
LPCAT1		V	V
AGPS			V
PLD1			V
PLA2G2A				V
TMEM86B				V
ENPP2				V
+ 00600: Sphingolipid metabolism	1.9	1	0.7	0.9
CERS2	V	V	V	V
CERS4	V
SMPD4	V			V
SPTLC1	V
SPHK2	V	V	V
SPHK1	V
NEU3		V
NEU4		V	V
SPTLC3			V
GLB1			V	V
GBA				V
+ 00590: Arachidonic acid metabolism	0.1	0.3	0.2	0.3
PTGES3	V	V	V	V
AKR1C3	V			V
GPX1		V
PRXL2B		V
EPHX2			V
GPX7			V
CBR1			V
PLA2G2A				V
+ 00591: Linoleic acid metabolism	0	0	0	0.2
PLA2G2A				V
+ 00592: alpha-Linolenic acid metabolism	0	0	0	0.7
ACAA1				V
PLA2G2A				V
+ 01040: Biosynthesis of unsaturated fatty acids	1.3	0.7	0.7	3.2
HSD17B4	V			V
ACOT7	V
ELOVL6	V
ACOT2		V
ELOVL5		V	V	V
SCP2			V	V
ELOVL1			V	V
HACD1				V
ACAA1				V
ELOVL7				V
+ 1.4 Nucleotide metabolism	2.2	3	4.5	2.6
+ 00230: Purine metabolism	1.5	1.9	2.6	1.8
NME2	V		V	V
NME1-NME2	V		V	V
NME4	V
AK6	V	V	V	V
AK4	V
NT5C3A	V
IMPDH1	V	V
DGUOK	V
NUDT9	V			V
FHIT	V
PKM	V	V
RRM2		V	V
GART		V	V
AK2		V	V
NT5C3B		V
CANT1		V	V
ENTPD6		V		V
ENTPD4		V	V
PAPSS2		V
ITPA		V	V	V
PDE4D		V
RRM1			V
PRPS1			V	V
PAICS			V
ADCY7			V
AK9			V
NME1			V
NT5C			V
NT5E			V
IMPDH2			V
PRUNE1			V
PGM1			V
ENPP3			V
RRM2B				V
ADSL				V
ADCY9				V
ENTPD2				V
NT5C2				V
AK3				V
+ 00240: Pyrimidine metabolism	1.6	2.3	3.7	1.8
NME2	V		V	V
NME1-NME2	V		V	V
NME4	V
CTPS1	V	V	V	V
NT5C3A	V
UPP1	V			V
RRM2		V	V
CANT1		V	V
ENTPD6		V		V
ENTPD4		V	V
UCK2		V
NT5C3B		V
TYMP		V
RRM1			V
AK9			V
NME1			V
UCK1			V
NT5C			V
NT5E			V
DTYMK			V
ENPP3			V
DUT			V
RRM2B				V
NT5C2				V
+ 1.5 Amino acid metabolism	3.6	2.9	4.9	3.6
+ 00250: Alanine, aspartate and glutamate metabolism	0.9	0.1	0.4	2.2
GPT2	V			V
ALDH5A1	V
GFPT1	V
ASS1		V
ASL			V	V
GLS2			V
CPS1			V
ASNS				V
ADSL				V
AGXT				V
GLUL				V
+ 00260: Glycine, serine and threonine metabolism	1.3	0.4	1.4	1.6
SHMT2	V	V	V	V
ALAS1	V
AOC3	V
GLYCTK	V
CHDH		V		V
SRR			V
CBSL			V	V
CBS			V	V
SHMT1			V
SDSL			V
AGXT				V
+ 00270: Cysteine and methionine metabolism	2.3	2.2	2.8	2.1
AMD1	V		V
KYAT1	V			V
MAT1A	V			V
DNMT3A	V
LDHA	V	V		V
MDH1	V		V
BCAT1	V	V	V
MTR		V
MAT2A		V	V
AHCYL1		V
SMS		V
GCLC		V
CBSL			V	V
CBS			V	V
MAT2B			V
SDSL			V
CDO1			V
MDH2			V
GSS			V
KYAT3				V
MPST				V
+ 00280: Valine, leucine and isoleucine degradation	1	2.2	2.1	0.9
IVD	V	V	V
BCAT1	V	V	V
ALDH3A2	V	V	V	V
ACADM	V	V
HMGCL		V
AUH		V
HADHB		V	V
HMGCS2			V
MCCC1			V
EHHADH			V
HIBCH			V
ACAD8			V
ACAA1				V
PCCA				V
ACSF3				V
+ 00290: Valine, leucine and isoleucine biosynthesis	1.2	1.2	2	0
BCAT1	V	V	V
SDSL			V
+ 00310: Lysine degradation	1.9	0.2	1.7	1
EZH2	V		V
KMT2E	V		V
KMT2C	V
KMT2D	V
SETDB2	V
SETD1A	V			V
ALDH3A2	V	V	V	V
SETDB1		V
EHHADH			V
AADAT			V
DLST			V
GCDH			V
EHMT2			V	V
PRDM2			V
COLGALT1				V
PLOD1				V
+ 00220: Arginine biosynthesis	0.4	0.9	1.5	2
GPT2	V			V
ASS1		V
ACY1		V
GLS2			V
CPS1			V
ASL			V	V
ABHD14A-ACY1			V
GLUL				V
ARG2				V
+ 00330: Arginine and proline metabolism	1.8	1.8	0.4	2.1
ALDH3A2	V	V	V	V
AMD1	V		V
CKB	V
CKMT1B	V			V
CKMT1A	V			V
PYCR1	V	V		V
SMS		V
SAT2		V
AGMAT		V	V
ODC1		V		V
CNDP2			V
ARG2				V
SMOX				V
+ 00340: Histidine metabolism	0.3	1.4	1.9	0.3
ALDH3A2	V	V	V	V
FTCD		V	V
HAL		V
UROC1			V
CNDP2			V
ALDH3B1			V
+ 00350: Tyrosine metabolism	1	0	0.8	0.1
GSTZ1	V		V
AOC3	V
ADH6	V
ALDH3B1			V
DDC			V
COMT			V	V
+ 00360: Phenylalanine metabolism	0.5	0	0.7	0
AOC3	V
ALDH3B1			V
DDC			V
+ 00380: Tryptophan metabolism	0.4	0.1	2	0.7
KYAT1	V			V
ALDH3A2	V	V	V	V
EHHADH			V
DDC			V
AFMID			V
GCDH			V
DLST			V
KYNU			V
AADAT			V
KYAT3				V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	0
+ 1.6 Metabolism of other amino acids	1.5	2.3	2.5	1.4
+ 00410: beta-Alanine metabolism	0.6	0.5	1.3	0.5
AOC3	V
ALDH3A2	V	V	V	V
SMS		V
EHHADH			V
HIBCH			V
ALDH3B1			V
CNDP2			V
SMOX				V
+ 00430: Taurine and hypotaurine metabolism	0	0	0.4	0
CDO1			V
+ 00440: Phosphonate and phosphinate metabolism	1	0	0.8	0
SELENOI	V
PCYT1B			V
+ 00450: Selenocompound metabolism	1.1	2.4	0.2	1.7
TXNRD1	V			V
KYAT1	V			V
TXNRD2		V	V
MARS		V
PAPSS2		V
MTR		V
KYAT3				V
+ 00471: D-Glutamine and D-glutamate metabolism	0	0	1.8	0
DGLUCY			V
GLS2			V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0
+ 00480: Glutathione metabolism	1.2	3.1	2.1	1.4
IDH1	V		V	V
GSTT1	V	V	V	V
GSTK1	V
MGST2	V			V
GSR	V	V		V
GPX1		V
GCLC		V
GGCT		V
GSTM4		V	V
MGST1		V	V
ODC1		V		V
SMS		V
RRM2		V	V
GPX7			V
G6PD			V
GSS			V
NAT8			V
RRM1			V
RRM2B				V
+ 1.7 Glycan biosynthesis and metabolism	1.3	2.1	1.6	3.3
+ 00510: N-Glycan biosynthesis	0.3	0.5	0.2	2.1
B4GALT2	V			V
RPN2	V			V
DPM3		V	V
B4GALT3		V
MAN2A2		V
ST6GAL1			V
ALG8			V
MAN1B1				V
MGAT4B				V
STT3A				V
DPM1				V
MGAT1				V
+ 00512: Mucin type O-glycan biosynthesis	0	0	0	0.2
GALNT2				V
+ 00515: Mannose type O-glycan biosynthesis	0.3	0.3	0.1	0.8
B4GALT2	V			V
B4GALT3		V
CHST10			V
LARGE2				V
+ 00514: Other types of O-glycan biosynthesis	0.9	0.8	0.5	3.1
B4GALT2	V			V
OGT	V			V
B4GALT3		V
GXYLT1		V	V
ST6GAL1			V
COLGALT1				V
MFNG				V
RFNG				V
POFUT2				V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	0	0	0.4
CHPF				V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0	0	0	0
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	1.3	0.5	0	0.5
B4GALT2	V			V
B4GALT4	V
B4GALT3		V
+ 00531: Glycosaminoglycan degradation	0.4	2.2	1.1	0.9
HYAL1	V
SGSH		V
ARSB		V
HYAL3		V	V
HGSNAT		V
IDS			V
GLB1			V	V
HYAL2				V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0.3	1.4	2.4	0.8
PIGT	V	V	V	V
PIGW		V	V
PIGZ		V	V
PIGF			V
PIGO			V
PIGV			V
PIGS				V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0.7	0.2	0	0.7
B4GALT4	V
B4GALT2	V			V
B4GALT3		V
A4GALT				V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0	0.5
A4GALT				V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0.5	0	0.3	1.2
B4GALNT1	V
GLB1			V	V
ST6GALNAC4				V
+ 00511: Other glycan degradation	0	1.7	1.2	1
NEU3		V
NEU4		V	V
MAN2C1		V	V
GLB1			V	V
GBA				V
+ 1.8 Metabolism of cofactors and vitamins	1.1	2.5	4	0.8
+ 00730: Thiamine metabolism	1.2	0.5	0.3	0
AK4	V
NFS1	V
AK2		V	V
+ 00740: Riboflavin metabolism	0	1.7	1.4	0
RFK		V
ACP2		V	V
ENPP3			V
+ 00750: Vitamin B6 metabolism	0	0	0	0
+ 00760: Nicotinate and nicotinamide metabolism	0.2	0.6	1.4	1
NT5C3A	V
NMRK1		V
NT5C3B		V
ENPP3			V
NMNAT1			V
NADK2			V	V
NT5C			V
NT5E			V
NADSYN1				V
NT5C2				V
+ 00770: Pantothenate and CoA biosynthesis	0.4	1.6	1.7	0.4
BCAT1	V	V	V
PANK4		V
PPCS		V	V
COASY			V
ENPP3			V
VNN1				V
+ 00780: Biotin metabolism	0	0	2.2	0
HLCS			V
BTD			V
+ 00785: Lipoic acid metabolism	0	0	1.1	0
LIPT2			V
+ 00790: Folate biosynthesis	1.3	0.3	1.3	0.2
QDPR	V		V
AKR1B1	V
AKR1C3	V			V
DHFR		V	V
DHFR2			V
CBR1			V
+ 00670: One carbon pool by folate	0.4	3.3	3.1	0.3
SHMT2	V	V	V	V
FTCD		V	V
GART		V	V
DHFR		V	V
ALDH1L1		V
MTR		V
DHFR2			V
MTHFR			V
SHMT1			V
+ 00830: Retinol metabolism	0.1	0.3	0.1	0
ADH6	V
DHRS4	V	V	V
DGAT1		V	V
DHRS3		V
UGT2B10			V
UGT2A3				V
+ 00860: Porphyrin and chlorophyll metabolism	0.1	0.3	0.9	0.7
ALAS1	V
HCCS		V	V
HMOX2		V	V	V
UGT2B10			V
BLVRA			V
UROS			V
UGT2A3				V
CP				V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0	0	0.5	0
VKORC1L1			V
+ 1.9 Metabolism of terpenoids and polyketides	1.4	0.8	0.9	2.5
+ 00900: Terpenoid backbone biosynthesis	1.4	0.8	0.9	2.5
HMGCR	V			V
FDPS	V	V		V
ICMT	V			V
PDSS1		V	V
HMGCS2			V
DHDDS			V
IDI1				V
RCE1				V
+ 1.10 Biosynthesis of other secondary metabolites	0	0	0	0.8
+ 00232: Caffeine metabolism	0	0	0	0
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	0	1.1
HK2				V
+ 1.11 Xenobiotics biodegradation and metabolism	1.5	1.4	1.7	1.4
+ 00980: Metabolism of xenobiotics by cytochrome P450	0.5	0.4	0.3	0.4
GSTT1	V	V	V	V
GSTK1	V
MGST2	V			V
ADH6	V
GSTM4		V	V
MGST1		V	V
CYP2D6		V
UGT2B10			V
ALDH3B1			V
CBR1			V
UGT2A3				V
AKR1C1				V
+ 00982: Drug metabolism - cytochrome P450	0.5	0.5	0.2	0.2
GSTT1	V	V	V	V
GSTK1	V
MGST2	V			V
ADH6	V
CYP2D6		V
GSTM4		V	V
MGST1		V	V
ALDH3B1			V
UGT2B10			V
UGT2A3				V
+ 00983: Drug metabolism - other enzymes	1.7	1.6	2.4	1.8
UPP1	V			V
IMPDH1	V	V
CES1	V		V	V
NME2	V		V	V
NME1-NME2	V		V	V
NME4	V
GSTT1	V	V	V	V
MGST2	V			V
ITPA		V	V	V
TYMP		V
UCK2		V
RRM2		V	V
GSTM4		V	V
MGST1		V	V
UCK1			V
IMPDH2			V
UGT2B10			V
NME1			V
RRM1			V
DUT			V
UGT2A3				V
RRM2B				V
+ 2. Genetic Information Processing	6.4	6.3	12.4	5.5
+ 2.1 Transcription	3.2	2.5	4.3	2.1
+ 03020: RNA polymerase	2.6	2.6	2.7	1.5
POLR2B	V	V	V
POLR2E	V	V	V	V
POLR2H	V	V	V
POLR2J2	V			V
POLR2J3	V			V
POLR1C	V
POLR1D		V
POLR3H		V	V
POLR1B		V	V
POLR2L			V
POLR3C			V
POLR1A			V
POLR3D				V
+ 03022: Basal transcription factors	2	1.5	1.1	1.4
TAF4	V	V		V
GTF2A1	V
GTF2H1	V
GTF2H4	V		V
TAF15	V			V
CDK7	V	V
TAF4B		V	V
TAF6		V
GTF2I		V	V	V
GTF2F2			V
GTF2H2C			V	V
GTF2H2C_2			V	V
+ 03040: Spliceosome	0.9	0.4	3.6	0.7
DHX8	V	V	V	V
SNRPB	V
SNRPD2	V
U2AF2	V		V
HSPA1A	V
HSPA1B	V
PQBP1	V	V	V	V
EFTUD2	V
ACIN1	V
SNRPG		V
PUF60		V	V	V
HNRNPM		V	V
LSM2		V	V
PPIH		V	V
DHX16			V	V
RBM25			V
SNRPD3			V
SNRPB2			V
U2SURP			V
HNRNPA1L2			V
HNRNPK			V	V
TRA2A			V
SRSF2			V
SRSF3			V
SRSF5			V
SRSF6			V
SRSF7			V
PPIE			V
LSM5			V
PRPF4			V
USP39			V	V
THOC2			V
PRPF38A			V
SF3B1				V
CRNKL1				V
SNU13				V
+ 2.2 Translation	2.6	3.3	7.1	3.2
+ 03010: Ribosome	0.6	2.1	4.3	0.7
RPL13	V
RPS24	V		V
RPL11	V			V
RPL17	V	V	V	V
RPL15	V	V	V
RPL30	V
RPL10	V	V		V
MRPL21	V
MRPL10		V	V
MRPL11		V	V
MRPL13		V	V
RPL17-C18orf32		V	V
UBA52		V	V
RPL41		V	V
RPL31		V	V
RPS15A		V	V
RPS20		V	V
RPSA		V	V	V
RPS9		V
RPS15			V
RPS26			V
RPL26L1			V
MRPL24			V
RPL18			V
RPL21			V
RPL32			V
RPL14			V
MRPL4			V
MRPL20			V
MRPL33			V
MRPS7			V
RPS3			V
MRPS14			V
MRPS18C			V	V
MRPL1			V
RPL9				V
RPL27A				V
RPL26				V
MRPS11				V
+ 00970: Aminoacyl-tRNA biosynthesis	0.7	1.5	2.7	1.4
CARS	V			V
GARS	V			V
YARS2	V			V
NARS		V	V
HARS		V	V
MARS		V
VARS2		V
LARS		V	V
FARSB			V
RARS2			V
DARS			V
TARS			V
TARS2			V
WARS			V	V
PARS2			V
IARS				V
+ 03013: RNA transport	2	1.6	3.5	2
CLNS1A	V		V
SMN1	V		V	V
SMN2	V		V	V
ACIN1	V
NUP58	V			V
NUP98	V	V	V	V
NUP42	V
EIF1AY	V
EIF3CL	V			V
THOC5	V	V		V
THOC7	V
PABPC4	V			V
EIF4G2	V
UPF3A	V			V
CYFIP1	V	V	V	V
RAN		V
GEMIN8		V	V
RNPS1		V	V
NUP62		V	V
NUP155		V
NUP107		V	V
NUP85		V	V
POM121		V	V
PRMT5		V
EIF3J		V
EIF4A1		V	V
GEMIN7			V
GEMIN6			V
NXT2			V
AAAS			V
EIF3C			V	V
RPP30			V
RPP38			V
POP4			V
POP5			V
ELAC2			V
THOC2			V
PAIP1			V
EIF4E2			V
EIF5			V
TACC3			V
EIF2B3			V
NUP35			V
XPOT				V
POM121C				V
NUP88				V
EEF1A2				V
EIF4G1				V
EIF4B				V
+ 03015: mRNA surveillance pathway	0.8	1.3	2.1	1.6
ACIN1	V
UPF3A	V			V
ETF1	V		V	V
PAPOLA	V	V
PABPN1	V
PABPC4	V			V
RNPS1		V	V
CPSF7		V	V
CPSF1		V		V
PPP2R1B		V	V
PPP2R5C		V	V
WDR33		V	V
PPP1CA		V		V
NXT2			V
SMG7			V
PCF11			V
CSTF1			V
CSTF2			V
CSTF3			V
PPP2R5E			V	V
DAZAP1			V	V
PPP2R5B				V
PPP2R2D				V
+ 03008: Ribosome biogenesis in eukaryotes	1.7	0.9	3.3	1.5
NHP2	V			V
DKC1	V	V	V	V
BMS1	V
GNL3L	V		V
IMP3	V		V
LSG1	V			V
AK6	V	V	V	V
RBM28	V			V
RAN		V
FBL		V	V
XRN2		V
CSNK2B		V	V
TCOF1			V
NOP58			V
RPP30			V
RPP38			V
POP4			V
POP5			V
NVL			V
NXT2			V
UTP4			V
WDR3			V
CSNK2A1			V
SNU13				V
RCL1				V
XRN1				V
+ 2.3 Folding, sorting and degradation	3.7	3.1	4.7	3.4
+ 03060: Protein export	0.3	0.3	0.4	0.3
SEC11A	V	V	V	V
SEC11C			V
+ 04141: Protein processing in endoplasmic reticulum	3.9	2	2.1	4.1
MAP2K7	V	V	V
CANX	V		V
CAPN1	V			V
RPN2	V			V
SEC23B	V		V	V
PRKCSH	V		V	V
MARCH6	V
UBE2G2	V			V
ATF6B	V	V	V	V
RAD23B	V
NGLY1	V	V	V	V
HSPA1A	V
HSPA1B	V
ERLEC1	V			V
UBE2D3	V		V
STUB1	V		V	V
TXNDC5	V
RNF5	V			V
HSP90AA1	V			V
NFE2L2	V		V	V
HSPBP1	V	V	V	V
SIL1	V
RRBP1	V		V
MAPK9		V
EDEM3		V
SEC24C		V	V
BAX		V
PDIA6		V
DNAJC10		V		V
HSP90AB1		V
SEC31A		V
HSPH1		V	V
CRYAA2		V
CRYAA		V
SSR3		V	V
ATF4			V
UFD1			V
UBE2J2			V	V
UBE4B			V
DNAJB12			V
TRAM1			V
CRYAB			V
BCAP31			V
SSR1			V	V
DDIT3				V
STT3A				V
MAN1B1				V
RAD23A				V
OS9				V
UBE2D2				V
PDIA4				V
RNF185				V
HYOU1				V
+ 04130: SNARE interactions in vesicular transport	2	0.9	1.2	0.9
STX5	V
GOSR2	V
STX10	V		V
STX4	V	V	V
VAMP2	V			V
STX6		V	V
SNAP23		V
STX18			V
VAMP7			V
USE1				V
VTI1B				V
+ 04120: Ubiquitin mediated proteolysis	1.6	1.8	4.4	1.9
SAE1	V
BTRC	V		V
ANAPC11	V		V	V
CUL4A	V	V	V	V
TRIM37	V		V	V
XIAP	V
UBE2D3	V		V
ITCH	V		V
UBE2K	V	V	V
UBE2G2	V			V
STUB1	V		V	V
WWP2	V	V		V
RHOBTB2		V	V
KLHL9		V	V
HERC3		V	V
CDC16		V	V	V
ANAPC2		V	V
UBE3C		V	V
UBA6		V
TRIP12		V
ANAPC13		V	V
UBE2E3		V
FBXO4			V
SKP2			V
DET1			V
UBA3			V
ANAPC4			V
CDC27			V
CUL2			V
BRCA1			V
PIAS1			V
PML			V
UBE2A			V
UBE2J2			V	V
UBE4B			V
UBE4A			V
UBE2Q2			V
UBA2				V
FZR1				V
BIRC7				V
SIAH1				V
UBE2D2				V
NEDD4L				V
+ 04122: Sulfur relay system	0.9	0	0.6	0.8
NFS1	V
MOCS3			V
MPST				V
+ 03050: Proteasome	0	1.5	1.1	0.1
PSMD2		V	V
PSMC2		V	V
PSMA4		V	V
PSMA1		V	V
PSMB6		V
PSME3			V
PSMB5			V	V
+ 03018: RNA degradation	1	1.6	2.5	0.9
ENO3	V	V
EXOSC7	V
C1D	V
CNOT2	V	V
DCP2	V	V
PABPC4	V			V
CNOT1		V	V
CNOT8		V		V
DCP1B		V	V
LSM2		V	V
XRN2		V
PNPT1			V
EXOSC2			V
DIS3			V
SKIV2L			V
EXOSC9			V
CNOT9			V
LSM5			V
EDC3			V
EDC4			V
PARN			V
BTG3			V
ENO2				V
CNOT10				V
XRN1				V
DDX6				V
+ 2.4 Replication and repair	3.3	3.6	8.7	2.3
+ 03030: DNA replication	1.4	1.3	4	0.8
DNA2	V
RFC2	V		V
RFC3	V		V	V
MCM3	V		V	V
LIG1		V
RNASEH2B		V
RFC4		V	V
MCM7		V
FEN1			V
RFC5			V
PCNA			V
MCM4			V
POLA2			V
POLD1			V
MCM6			V
RPA2			V
SSBP1				V
+ 03410: Base excision repair	0.2	1.5	3.4	0.5
HMGB1	V			V
APEX1		V	V
PARP4		V
LIG1		V
MPG		V	V
FEN1			V
LIG3			V
POLD1			V
PCNA			V
UNG			V
OGG1			V	V
MBD4			V
SMUG1			V
+ 03420: Nucleotide excision repair	2.8	1	2.9	1.3
GTF2H4	V		V
GTF2H1	V
CDK7	V	V
CUL4A	V	V	V	V
RFC2	V		V
RFC3	V		V	V
RAD23B	V
ERCC6	V
LIG1		V
RFC4		V	V
GTF2H2C			V	V
GTF2H2C_2			V	V
RFC5			V
PCNA			V
POLD1			V
RPA2			V
RAD23A				V
+ 03430: Mismatch repair	2	2	3.3	1.9
MLH1	V	V	V
EXO1	V
RFC2	V		V
RFC3	V		V	V
MSH2		V		V
LIG1		V
RFC4		V	V
PCNA			V
POLD1			V
RPA2			V
RFC5			V
MSH6				V
SSBP1				V
+ 03440: Homologous recombination	0.8	0.7	3.6	0.3
XRCC3	V
RAD51D	V
RAD54B	V
RAD51C		V	V
BABAM2		V	V
BRCC3		V	V
RAD52			V
RAD50			V
NBN			V
RPA2			V
RAD51			V
EME1			V
RAD54L			V
POLD1			V
BRCA1			V
SSBP1				V
RBBP8				V
+ 03450: Non-homologous end-joining	0	0.6	2.2	0
XRCC5		V	V
RAD50			V
XRCC4			V
FEN1			V
+ 03460: Fanconi anemia pathway	1.7	2.4	3.6	1.1
FANCA	V		V
MLH1	V	V	V
WDR48	V	V
REV3L	V	V	V	V
SLX1A	V			V
SLX1B	V			V
FANCC		V	V
FANCI		V
RAD51C		V	V
FAN1		V
CENPX		V
FANCG			V
ATRIP			V
RPA2			V
BRCA1			V
UBE2T			V	V
REV1			V
EME1			V
EME2			V
RAD51			V
HES1				V
+ 3. Environmental Information Processing	5.8	4	2.3	4.5
+ 3.1 Membrane transport	0.3	1.5	0.8	0.1
+ 02010: ABC transporters	0.3	1.5	0.8	0.1
ABCC2	V
ABCB4	V
ABCD3		V
ABCC1		V	V
ABCB9		V
ABCB8		V	V
ABCA1		V
ABCC3			V
TAP1			V
ABCA5			V
ABCC10				V
+ 3.2 Signal transduction	9.4	5	3.2	6.5
+ 04010: MAPK signaling pathway	5.3	1.3	0.6	3.8
MAP4K4	V	V	V	V
MAPT	V	V	V
NFKB2	V			V
RELA	V
MAPK1	V
RAF1	V
RAP1A	V	V
MRAS	V
HRAS	V
EGFR	V
ERBB2	V	V
FGFR3	V		V
INSR	V			V
MET	V			V
PDGFRB	V			V
NR4A1	V			V
CDC25B	V	V
ATF2	V			V
MAPK14	V			V
MAP2K3	V
STK3	V			V
ECSIT	V	V	V
GADD45A	V
DAXX	V	V	V	V
TGFBR1	V
IL1RAP	V			V
RAC1	V			V
MAP3K2	V		V
MAP2K7	V	V	V
ARRB2	V			V
HSPA1A	V
HSPA1B	V
JUND	V			V
NFATC3	V		V	V
PPP3CC	V
MAP4K3	V		V
RPS6KA3	V
IGF2	V			V
PGF	V	V
TGFA	V
VEGFA	V	V	V	V
IRAK1	V	V
DUSP16		V
RAP1B		V	V
IGF1R		V	V
TP53		V	V
CDC42		V	V
MAPK8IP1		V	V
MAPK9		V
FLNB		V	V	V
MYC		V	V
EFNA2		V
MYD88		V	V
IKBKG			V
PRKACB			V
FGFR4			V	V
ATF4			V
MAP2K6			V
MAP3K4			V
MAP3K6			V	V
MAP3K3			V
MAPK8IP3			V
IRAK4			V	V
DUSP1				V
DUSP8				V
DUSP9				V
STMN1				V
LAMTOR3				V
ERBB3				V
MAPKAPK2				V
DDIT3				V
AKT1				V
TAOK1				V
GADD45B				V
TGFB1				V
MAP3K11				V
JUN				V
CSF1				V
+ 04012: ErbB signaling pathway	2.2	1.8	0.8	0.3
STAT5A	V	V	V
ERBB2	V	V
EGFR	V
GSK3B	V
PAK4	V		V
TGFA	V
MAP2K7	V	V	V
MAPK1	V
RAF1	V
HRAS	V
RPS6KB1		V	V
NCK2		V	V
MAPK9		V
SHC1		V
PIK3CB		V
MYC		V	V
PTK2			V
PLCG1			V
SRC			V
ERBB3				V
CDKN1A				V
JUN				V
AKT1				V
+ 04014: Ras signaling pathway	2.4	0.4	0.1	0.4
MAPK1	V
RAF1	V
MRAS	V
HRAS	V
IGF2	V			V
PGF	V	V
TGFA	V
VEGFA	V	V	V	V
EGFR	V
FGFR3	V		V
INSR	V			V
MET	V			V
PDGFRB	V			V
RAC1	V			V
RGL2	V	V
RELA	V
RAP1A	V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNB1	V		V	V
PAK4	V		V
PIK3CB		V
SHC1		V
EFNA2		V
IGF1R		V	V
MAPK9		V
CDC42		V	V
RAB5B		V
RAP1B		V	V
EXOC2		V	V
FGFR4			V	V
PLD1			V
IKBKG			V
PLCG1			V
PRKACB			V
AKT1				V
CSF1				V
BCL2L1				V
FOXO4				V
PLA2G2A				V
+ 04015: Rap1 signaling pathway	3.4	1.4	0.8	0.4
MAPK1	V
RAF1	V
RAP1A	V	V
PGF	V	V
VEGFA	V	V	V	V
EGFR	V
FGFR3	V		V
INSR	V			V
MET	V			V
PDGFRB	V			V
RAC1	V			V
MAP2K3	V
MAPK14	V			V
PFN1	V
CDH1	V	V
RAP1GAP	V
GNAS	V
FARP2	V
MRAS	V
HRAS	V
CTNND1	V			V
CALM1	V		V
CALM2	V		V
CALM3	V		V
BCAR1	V	V
RAP1B		V	V
EFNA2		V
IGF1R		V	V
SIPA1L1		V
ITGB1		V	V
ITGB2		V	V	V
PRKD2		V	V
KRIT1		V
CDC42		V	V
GNAI1		V	V
GNAI2		V
PIK3CB		V
FGFR4			V	V
MAP2K6			V
ITGAL			V
CTNNB1			V
PARD3			V
PRKD3			V
SRC			V
ADCY7			V
PLCG1			V
CSF1				V
ADCY9				V
AKT1				V
+ 04310: Wnt signaling pathway	0.7	0.4	0.9	0.8
NFATC3	V		V	V
PPP3CC	V
RAC1	V			V
TCF7L2	V
BTRC	V		V
AXIN1	V			V
AXIN2	V			V
PSEN1	V			V
GSK3B	V
CBY1	V		V
MAPK9		V
GPC4		V	V
MYC		V	V
TBL1X		V	V
TBL1XR1		V	V
TP53		V	V
CSNK2B		V	V
LRP5		V		V
LGR5		V	V
PRICKLE4			V
RUVBL1			V
CSNK1A1			V
CACYBP			V
CTNNB1			V
PRKACB			V
CSNK2A1			V
JUN				V
TCF7				V
CREBBP				V
CTNNBIP1				V
SIAH1				V
+ 04330: Notch signaling pathway	1.9	0.1	0	2.1
NCSTN	V			V
PSEN1	V			V
PSEN2	V
HDAC2	V
RBPJ	V			V
DTX2	V
APH1A		V	V
HES1				V
CREBBP				V
MFNG				V
RFNG				V
+ 04340: Hedgehog signaling pathway	1.9	0.3	1.1	0.9
CSNK1G3	V			V
GSK3B	V
BTRC	V		V
CDON	V			V
ARRB2	V			V
SPOPL	V
SUFU		V	V
KIF3A		V
CSNK1A1			V
PRKACB			V
IHH			V
SPOP			V	V
+ 04350: TGF-beta signaling pathway	0.2	1.9	1.6	1.1
SP1	V	V
MAPK1	V
TGFBR1	V
TGIF2	V		V	V
SMAD6		V
SMAD7		V	V
MYC		V	V
RPS6KB1		V	V
PPP2R1B		V	V
BMP4		V		V
CHRD		V	V
TGIF1		V	V
GREM1		V	V
ACVR1B			V
RBL1			V
ACVR1			V	V
DCN			V
SMAD5			V
CREBBP				V
ID2				V
INHBE				V
TGFB1				V
HAMP				V
+ 04390: Hippo signaling pathway	1.3	1	0.7	1.9
STK3	V			V
YAP1	V	V	V	V
AMOT	V
CDH1	V	V
SCRIB	V	V		V
TEAD4	V		V
BTRC	V		V
TGFBR1	V
GSK3B	V
AXIN1	V			V
AXIN2	V			V
TCF7L2	V
BIRC5		V	V
PPP1CA		V		V
TEAD3		V	V
ITGB2		V	V	V
SMAD7		V	V
MYC		V	V
BMP4		V		V
PPP2R1B		V	V
CTNNA1			V
MOB1A			V	V
LLGL2			V
TEAD2			V
PARD3			V
CTNNB1			V
LATS1				V
TGFB1				V
SERPINE1				V
TCF7				V
ID2				V
PPP2R2D				V
+ 04392: Hippo signaling pathway - multiple species	1.2	0.6	1.5	1.6
STK3	V			V
YAP1	V	V	V	V
TEAD4	V		V
TEAD3		V	V
MOB1A			V	V
TEAD2			V
LATS1				V
+ 04370: VEGF signaling pathway	2.7	0.7	1	1
SPHK2	V	V	V
SPHK1	V
PPP3CC	V
MAPK14	V			V
VEGFA	V	V	V	V
MAPK1	V
RAF1	V
HRAS	V
RAC1	V			V
CDC42		V	V
PIK3CB		V
PLCG1			V
PTK2			V
SH2D2A			V
SRC			V
MAPKAPK2				V
AKT1				V
+ 04371: Apelin signaling pathway	2.4	1.5	0.8	0.4
PRKAA1	V	V	V	V
PRKAA2	V
SPHK2	V	V	V
SPHK1	V
GNB1	V		V	V
MAPK1	V
MRAS	V
HRAS	V
RAF1	V
TGFBR1	V
MEF2D	V
CDH1	V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
PRKAB2		V
PRKAG1		V	V
GNAI1		V	V
GNAI2		V
RPS6KB1		V	V
TFAM		V	V
HDAC5		V		V
PIK3C3		V	V
SPP1		V		V
ADCY7			V
PRKACB			V
PLIN1			V
SERPINE1				V
AKT1				V
ADCY9				V
GABARAPL1				V
+ 04064: NF-kappa B signaling pathway	1.2	0.3	0.5	1
IRAK1	V	V
NFKB2	V			V
RELA	V
TMED7-TICAM2	V			V
TICAM2	V
LY96	V
CFLAR	V			V
XIAP	V
MYD88		V	V
LTBR		V		V
TNFAIP3		V	V
CSNK2B		V	V
IRAK4			V	V
TRAF3			V
IKBKG			V
PLCG1			V
CSNK2A1			V
EDA2R			V
BCL2L1				V
MALT1				V
GADD45B				V
+ 04668: TNF signaling pathway	1.6	0.6	0.9	2
MAP2K7	V	V	V
MAP2K3	V
MAPK14	V			V
RELA	V
MAPK1	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
ITCH	V		V
CFLAR	V			V
MAPK9		V
CASP7		V	V
TNFAIP3		V	V
PIK3CB		V
PGAM5		V
MAP2K6			V
IKBKG			V
ATF4			V
CASP8			V
TRAF3			V
DNM1L			V
CEBPB				V
JUN				V
CX3CL1				V
CSF1				V
LIF				V
AKT1				V
DAB2IP				V
+ 04066: HIF-1 signaling pathway	2.6	2.8	1.3	3
VEGFA	V	V	V	V
ARNT	V
HIF1A	V	V	V	V
EGFR	V
ERBB2	V	V
INSR	V			V
LDHA	V	V		V
PDHA1	V	V	V	V
PDHB	V		V
ENO3	V	V
PFKFB3	V		V	V
RELA	V
MAPK1	V
EGLN2		V
IGF1R		V	V
PIK3CB		V
GAPDH		V	V
ALDOA		V	V
LTBR		V		V
IFNGR2		V	V	V
RPS6KB1		V	V
CUL2			V
PLCG1			V
EIF4E2			V
CREBBP				V
AKT1				V
HK2				V
ENO2				V
TFRC				V
SERPINE1				V
CDKN1A				V
+ 04068: FoxO signaling pathway	2.5	1	0.2	1.5
MAPK1	V
PRKAA1	V	V	V	V
PRKAA2	V
HRAS	V
INSR	V			V
RAF1	V
PCK2	V	V		V
PDPK1	V	V
EGFR	V
CDK2	V
GADD45A	V
ATG12	V
TGFBR1	V
MAPK14	V			V
USP7	V
MAPK9		V
PRKAB2		V
PRKAG1		V	V
G6PC		V
PIK3CB		V
IGF1R		V	V
BCL6		V		V
G6PC3			V
SKP2			V
CCNB1			V
CDKN2D			V
PLK4			V
TNFSF10			V
SGK2			V
FOXO4				V
AKT1				V
CREBBP				V
CDKN1A				V
GADD45B				V
GABARAPL1				V
TGFB1				V
+ 04020: Calcium signaling pathway	0.7	0	0	0.2
VDAC2	V
PPP3CC	V
EGFR	V
ERBB2	V	V
PDGFRB	V			V
SPHK2	V	V	V
SPHK1	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNAS	V
ASPH	V	V
TPCN1		V
ATP2A2		V
PLCG1			V
PHKA1			V
ADCY7			V
PRKACB			V
ATP2B4			V
CAMK1				V
ERBB3				V
GNA11				V
PLCD3				V
PHKA2				V
PTAFR				V
ADCY9				V
STIM1				V
+ 04070: Phosphatidylinositol signaling system	2.2	2	1.2	1
CALM1	V		V
CALM2	V		V
CALM3	V		V
PIP5K1A	V		V
SYNJ2	V			V
PIP4K2C	V	V	V	V
PIP4K2B	V			V
IMPA1	V	V		V
INPP5A	V
INPPL1	V			V
IP6K2	V	V		V
PIK3CB		V
PIK3C2B		V
DGKD		V
IPMK		V
ITPK1		V	V
MTMR3		V
PPIP5K1		V	V
PIK3C3		V	V
PLCG1			V
PI4K2B			V
PIK3C2A			V
SACM1L			V
PLCD3				V
INPP1				V
+ 04072: Phospholipase D signaling pathway	1.2	0.2	0	0
MAPK1	V
RAF1	V
MRAS	V
HRAS	V
EGFR	V
INSR	V			V
PDGFRB	V			V
PIP5K1A	V		V
GNAS	V
SPHK2	V	V	V
SPHK1	V
PIK3CB		V
SHC1		V
LPAR6		V
CYTH2		V
ARF1		V	V
DGKD		V
PLCG1			V
PLD1			V
ADCY7			V
DNM2			V
AGPAT1			V
AKT1				V
ADCY9				V
F2				V
+ 04071: Sphingolipid signaling pathway	2	1.9	0.4	0.7
MAPK1	V
RAF1	V
PDPK1	V	V
HRAS	V
SPTLC1	V
CERS2	V	V	V	V
CERS4	V
SPHK2	V	V	V
SPHK1	V
MAPK14	V			V
RELA	V
RAC1	V			V
PIK3CB		V
GNAI1		V	V
GNAI2		V
ABCC1		V	V
PPP2R1B		V	V
PPP2R5C		V	V
MAPK9		V
BAX		V
TP53		V	V
SPTLC3			V
PPP2R5E			V	V
PLD1			V
AKT1				V
CTSD				V
PPP2R5B				V
PPP2R2D				V
+ 04024: cAMP signaling pathway	0.5	0.4	0.1	0.2
ATP1A1	V		V
GNAS	V
MAPK1	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
RAP1A	V	V
RAF1	V
CREB3L3	V		V	V
PPP1R12A	V	V	V	V
RELA	V
RAC1	V			V
ATP2A2		V
GNAI1		V	V
GNAI2		V
PIK3CB		V
RAP1B		V	V
MAPK9		V
PDE4D		V
PPARA		V	V
FXYD1		V	V
PPP1CA		V		V
ADCY7			V
PRKACB			V
ATP2B4			V
PLD1			V
MYL9			V
HCAR2				V
HCAR3				V
ADCY9				V
AKT1				V
CNGB1				V
CREBBP				V
JUN				V
+ 04022: cGMP-PKG signaling pathway	1.8	0.1	0.4	1.1
PPP1R12A	V	V	V	V
PPP3CC	V
NFATC3	V		V	V
MEF2D	V
RAF1	V
MAPK1	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
ATP1A1	V		V
VDAC2	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
INSR	V			V
PPP1CA		V		V
ATP2A2		V
GTF2I		V	V	V
GNAI1		V	V
GNAI2		V
MYL9			V
ATF4			V
ATP2B4			V
ADCY7			V
KCNMB3				V
CNGB1				V
GNA11				V
AKT1				V
ADCY9				V
+ 04151: PI3K-Akt signaling pathway	2.9	1.1	0.1	2.7
PDPK1	V	V
EGFR	V
ERBB2	V	V
FGFR3	V		V
INSR	V			V
MET	V			V
PDGFRB	V			V
GSK3B	V
PCK2	V	V		V
RELA	V
IGF2	V			V
PGF	V	V
TGFA	V
VEGFA	V	V	V	V
HRAS	V
HSP90AA1	V			V
PRKAA1	V	V	V	V
PRKAA2	V
CDK2	V
RAF1	V
MAPK1	V
GNB1	V		V	V
ITGB5	V			V
COL6A1	V
COL6A2	V
FN1	V	V		V
RAC1	V			V
IL4R	V
PRLR	V			V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
MCL1	V		V	V
NR4A1	V			V
RPS6KB1		V	V
MLST8		V	V
PIK3CB		V
IGF1R		V	V
LPAR6		V
MYC		V	V
TP53		V	V
G6PC		V
EFNA2		V
PPP2R1B		V	V
PPP2R5C		V	V
HSP90AB1		V
ITGB1		V	V
ITGB4		V	V
SPP1		V		V
CSF3R		V	V
IFNAR2		V
EIF4E2			V
FGFR4			V	V
G6PC3			V
IKBKG			V
PPP2R5E			V	V
PTK2			V
BRCA1			V
ATF4			V
SGK2			V
EIF4B				V
AKT1				V
ERBB3				V
BCL2L1				V
CSF1				V
PPP2R5B				V
PPP2R2D				V
CDKN1A				V
ITGA2				V
LAMB1				V
RELN				V
OSMR				V
PKN3				V
PIK3AP1				V
+ 04152: AMPK signaling pathway	1.4	2.1	0.9	3.1
PRKAA1	V	V	V	V
PRKAA2	V
INSR	V			V
PDPK1	V	V
CAMKK2	V	V	V	V
ACACA	V			V
PFKFB3	V		V	V
PCK2	V	V		V
HMGCR	V			V
CREB3L3	V		V	V
PRKAB2		V
PRKAG1		V	V
PIK3CB		V
IGF1R		V	V
ADIPOR1		V	V
G6PC		V
RPS6KB1		V	V
PPP2R1B		V	V
PPP2R5C		V	V
HNF4A			V
G6PC3			V
PPP2R5E			V	V
AKT1				V
ADIPOR2				V
PFKFB4				V
PPARG				V
PPP2R5B				V
PPP2R2D				V
ELAVL1				V
ULK1				V
+ 04150: mTOR signaling pathway	0.8	1	0.1	1.1
INSR	V			V
RAF1	V
MAPK1	V
HRAS	V
PDPK1	V	V
RPS6KA3	V
PRKAA1	V	V	V	V
PRKAA2	V
MIOS	V			V
GSK3B	V
IGF1R		V	V
PIK3CB		V
RPS6KB1		V	V
TBC1D7-LOC100130357		V
TBC1D7		V
GRB10		V
MLST8		V	V
MAPKAP1		V	V	V
LRP5		V		V
EIF4E2			V
SKP2			V
FNIP1			V
TTI1			V
AKT1				V
RRAGB				V
ULK1				V
NPRL3				V
LAMTOR3				V
EIF4B				V
CLIP1				V
+ 3.3 Signaling molecules and interaction	0.4	0.5	0	1.2
+ 04080: Neuroactive ligand-receptor interaction	0	0	0	0
PRLR	V			V
C3	V			V
THRA		V
THRB		V
LPAR6		V
GPR35		V		V
PARD3			V
C5			V	V
F2				V
PTAFR				V
+ 04060: Cytokine-cytokine receptor interaction	0	0	0	1
IL1RAP	V			V
TGFBR1	V
TNFRSF19	V		V
PRLR	V			V
IL4R	V
IL17RC	V	V		V
IL6ST		V	V
TNFRSF14		V
LTBR		V		V
IFNGR2		V	V	V
IFNAR2		V
CSF3R		V	V
CCL16		V	V
BMP4		V		V
ACVR1B			V
ACVR1			V	V
EDA2R			V
TNFSF10			V
IL22RA1				V
IL17RA				V
INHBE				V
TGFB1				V
OSMR				V
IL11RA				V
LIF				V
CX3CL1				V
CXCL16				V
TNFRSF12A				V
IL32				V
CSF1				V
INHA				V
GDF15				V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	0	0.2	0	0.1
CCL16		V	V
IL6ST		V	V
TNFRSF14		V
LTBR		V		V
TNFSF10			V
CX3CL1				V
IL22RA1				V
CSF1				V
+ 04512: ECM-receptor interaction	0.8	0.8	0	1.3
COL6A1	V
COL6A2	V
DAG1	V	V	V	V
FN1	V	V		V
HMMR	V	V	V
ITGB5	V			V
SPP1		V		V
ITGB1		V	V
ITGB4		V	V
LAMB1				V
RELN				V
ITGA2				V
FRAS1				V
+ 4. Cellular Processes	9.9	6.7	5.3	6.9
+ 4.1 Transport and catabolism	7.2	5	4.2	6.3
+ 04144: Endocytosis	4.5	2.4	3	2.7
STAM2	V
ITCH	V		V
LDLR	V		V	V
AP2M1	V		V
AP2S1	V	V		V
AP2A2	V	V	V	V
VPS37A	V			V
HSPA1A	V
HSPA1B	V
RNF103-CHMP3	V	V	V
CHMP3	V	V	V
HRAS	V
EPN1	V			V
EGFR	V
FGFR3	V		V
SH3GLB1	V	V	V	V
SH3GL1	V	V		V
ARRB2	V			V
PIP5K1A	V		V
ARFGEF2	V			V
ASAP1	V
ASAP3	V			V
SMAP2	V
ASAP2	V			V
RAB4A	V	V	V
RUFY1	V
HLA-A	V	V		V
HLA-B	V			V
TGFBR1	V
RAB11FIP3	V		V	V
ARPC2	V
SNX1	V		V
SNX5	V	V	V
CHMP5		V		V
CDC42		V	V
EPS15L1		V	V
RAB5B		V
IGF1R		V	V
GRK6		V
CYTH2		V
AGAP1		V		V
VPS45		V	V
ARF1		V	V
WASHC2A		V	V
CAPZB		V	V	V
SNX4		V
SNX3		V	V
SNX2		V
DNM2			V
RNF41			V
AP2B1			V
MVB12A			V
SNF8			V
PARD3			V
SRC			V
DAB2			V
FGFR4			V	V
PLD1			V
ARFGAP2			V
PML			V
CHMP7			V
RAB35			V
VPS26A			V
IST1			V	V
USP8				V
NEDD4L				V
CLTB				V
TFRC				V
RABEP1				V
RBSN				V
SNX12				V
+ 04145: Phagosome	1.1	0.4	0.1	1.9
C1R	V			V
ITGB5	V			V
RAC1	V			V
TUBA4A	V
ATP6V0B	V		V	V
ATP6V0A1	V
LAMP2	V			V
C3	V			V
CANX	V		V
HLA-A	V	V		V
HLA-B	V			V
ITGB2		V	V	V
ITGB1		V	V
PIK3C3		V	V
RAB5B		V
DYNC1LI2		V
TUBB2B		V	V
TUBB1		V
STX18			V
TUBA1A			V
TUBB			V	V
TAP1			V
ITGA2				V
DYNC1I2				V
ATP6V0C				V
SCARB1				V
TFRC				V
+ 04142: Lysosome	1.6	2.1	1.8	3.3
ATP6V0B	V		V	V
ATP6V0A1	V
CTSA	V	V	V	V
LAMP2	V			V
CD63	V		V	V
CD164	V	V
AP1G2	V		V
AP3S2	V			V
AP3D1	V
GGA3	V		V
HYAL1	V
LGMN		V	V
GAA		V		V
ARSB		V
SGSH		V
ACP2		V	V
PPT2		V
ABCB9		V
SLC11A2		V	V
ENTPD4		V	V
HGSNAT		V
AP1M1		V		V
GLB1			V	V
IDS			V
PPT1			V
CLN3			V	V
AP1M2			V
AP1B1			V
AP1G1			V
LITAF			V
ATP6V0C				V
CTSB				V
CTSD				V
GBA				V
PLA2G15				V
CD68				V
SORT1				V
CLTB				V
AP3B1				V
+ 04146: Peroxisome	2.3	1.2	3.2	2.1
PEX1	V
PEX13	V			V
HSD17B4	V			V
DHRS4	V	V	V
DECR2	V		V
ACSL1	V	V	V	V
ACSL5	V			V
IDH1	V		V	V
GSTK1	V
MPV17L	V			V
PEX5		V	V
PEX11B		V
ABCD3		V
AMACR		V	V
HMGCL		V
PEX11A			V
PEX3			V
AGPS			V
ACOX2			V
SCP2			V	V
CROT			V	V
EHHADH			V
SLC27A2			V
EPHX2			V
MPV17			V
NUDT7			V
ACAA1				V
AGXT				V
+ 04140: Autophagy - animal	4.5	2.5	0.6	3.7
PDPK1	V	V
MRAS	V
HRAS	V
RAF1	V
MAPK1	V
HIF1A	V	V	V	V
IGBP1	V		V
ATG13	V	V		V
RB1CC1	V
ATG2A	V			V
PRKAA1	V	V	V	V
PRKAA2	V
CAMKK2	V	V	V	V
AMBRA1	V
SH3GLB1	V	V	V	V
HMGB1	V			V
DAPK3	V			V
ATG12	V
ATG16L1	V
CFLAR	V			V
ATG4B	V
LAMP2	V			V
IGF1R		V	V
PIK3CB		V
MLST8		V	V
RPS6KB1		V	V
MAPK9		V
TP53INP2		V		V
PIK3C3		V	V
MTMR3		V
ATG5		V	V
PRKACB			V
ATG4C			V
AKT1				V
ULK1				V
RRAGB				V
BCL2L1				V
SUPT20H				V
GABARAPL1				V
ATG4D				V
CTSD				V
CTSB				V
+ 04136: Autophagy - other	2.6	1.5	1.3	1.5
ATG13	V	V		V
IGBP1	V		V
ATG2A	V			V
ATG4B	V
ATG16L1	V
ATG12	V
MLST8		V	V
PIK3C3		V	V
ATG5		V	V
ATG4C			V
GABARAPL1				V
ATG4D				V
+ 04137: Mitophagy - animal	2.5	3.1	1.1	1.5
AMBRA1	V
NBR1	V	V	V	V
TAX1BP1	V	V
HIF1A	V	V	V	V
RELA	V
MRAS	V
HRAS	V
SP1	V	V
CITED2	V	V
MFN2		V
CSNK2B		V	V
PGAM5		V
ATG5		V	V
TP53		V	V
MAPK9		V
SRC			V
CSNK2A1			V
ATF4			V
USP8				V
GABARAPL1				V
ULK1				V
BCL2L1				V
JUN				V
+ 4.2 Cell growth and death	5.4	4.1	3.8	3.6
+ 04110: Cell cycle	2.4	1.2	3.7	1.1
MCM3	V		V	V
ANAPC11	V		V	V
CHEK1	V		V	V
PTTG1	V
ESPL1	V
GADD45A	V
CDC25B	V	V
CDC45	V	V
GSK3B	V
CDK7	V	V
CDK2	V
STAG2	V			V
ZBTB17	V
HDAC2	V
MCM7		V
ANAPC13		V	V
ANAPC2		V	V
CDC16		V	V	V
CHEK2		V
TP53		V	V
MYC		V	V
MCM4			V
MCM6			V
ORC6			V
ORC3			V
ORC2			V
ORC5			V
ANAPC4			V
CDC27			V
BUB1B			V
PCNA			V
SKP2			V
CDC7			V
CDC25C			V
CDC6			V
CCNB1			V
CDKN2D			V
RBL1			V
FZR1				V
CDKN1A				V
CREBBP				V
GADD45B				V
TGFB1				V
+ 04114: Oocyte meiosis	2.4	0.7	2.5	0.6
RPS6KA3	V
MAPK1	V
ANAPC11	V		V	V
PTTG1	V
CDK2	V
BTRC	V		V
AURKA	V	V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
PPP3CC	V
CPEB4	V
MAPK14	V			V
ESPL1	V
ANAPC13		V	V
ANAPC2		V	V
CDC16		V	V	V
PPP1CA		V		V
PPP2R5C		V	V
PPP2R1B		V	V
IGF1R		V	V
ANAPC4			V
CDC27			V
CCNB1			V
CDC25C			V
PRKACB			V
ADCY7			V
PPP2R5E			V	V
SLK			V	V
ADCY9				V
PPP2R5B				V
+ 04210: Apoptosis	1.9	1.5	0.6	1.4
XIAP	V
RELA	V
CAPN1	V			V
CFLAR	V			V
LMNA	V	V	V
GADD45A	V
DAXX	V	V	V	V
PDPK1	V	V
TUBA4A	V
MCL1	V		V	V
HRAS	V
RAF1	V
MAPK1	V
DFFA		V	V
TP53		V	V
BIRC5		V	V
CASP7		V	V
PIK3CB		V
PARP4		V
DIABLO		V
BAX		V
MAPK9		V
CASP8			V
IKBKG			V
TNFSF10			V
LMNB1			V
ATF4			V
TUBA1A			V
BCL2L1				V
AKT1				V
GADD45B				V
DAB2IP				V
JUN				V
CTSB				V
CTSD				V
DDIT3				V
+ 04215: Apoptosis - multiple species	0.2	2	0.5	0.5
XIAP	V
CASP7		V	V
BIRC5		V	V
DIABLO		V
BAX		V
MAPK9		V
CASP8			V
BIRC7				V
BCL2L1				V
+ 04216: Ferroptosis	1.7	2.6	1.8	1.6
VDAC2	V
NCOA4	V		V
PRNP	V		V
ACSL1	V	V	V	V
ACSL5	V			V
TP53		V	V
GCLC		V
STEAP3		V
ATG5		V	V
SLC11A2		V	V
SAT2		V
GSS			V
TFRC				V
CP				V
SLC39A14				V
+ 04217: Necroptosis	1.4	1.5	0.3	0.9
XIAP	V
CFLAR	V			V
TMED7-TICAM2	V			V
TICAM2	V
STAT5A	V	V	V
STAT6	V	V		V
HMGB1	V			V
HSP90AA1	V			V
CAPN1	V			V
HIST1H2AC	V			V
RNF103-CHMP3	V	V	V
CHMP3	V	V	V
VDAC2	V
IFNAR2		V
IFNGR2		V	V	V
TNFAIP3		V	V
HSP90AB1		V
PGAM5		V
MAPK9		V
H2AFV		V	V
BAX		V
PARP4		V
CHMP5		V		V
TNFSF10			V
CASP8			V
TRPM7			V
STAT1			V
STAT2			V
DNM1L			V
CHMP7			V
RNF31				V
SPATA2L				V
GLUL				V
+ 04115: p53 signaling pathway	1.2	1.4	0.9	2.1
GADD45A	V
CHEK1	V		V	V
CDK2	V
CCNG1	V
ZMAT3	V			V
SHISA5	V		V	V
MDM4		V
CHEK2		V
RRM2		V	V
STEAP3		V
TP53I3		V
BAX		V
TP53		V	V
GTSE1			V
CASP8			V
SESN1			V
CCNB1			V
SIAH1				V
GADD45B				V
RRM2B				V
SERPINE1				V
CDKN1A				V
BCL2L1				V
+ 04218: Cellular senescence	4	0.6	0.6	1.9
MRAS	V
HRAS	V
RAF1	V
MAPK1	V
CDK2	V
MAPK14	V			V
MAP2K3	V
MYBL2	V			V
GADD45A	V
CHEK1	V		V	V
RELA	V
ZFP36L1	V	V		V
CAPN1	V			V
CALM1	V		V
CALM2	V		V
CALM3	V		V
PPP3CC	V
NFATC3	V		V	V
BTRC	V		V
TGFBR1	V
HLA-A	V	V		V
HLA-B	V			V
VDAC2	V
PPP1CA		V		V
MYC		V	V
HIPK1		V
HIPK2		V
TP53		V	V
PIK3CB		V
FOXM1		V
CHEK2		V
RBL1			V
MAP2K6			V
LIN54			V
RAD50			V
NBN			V
CCNB1			V
TRPM7			V
AKT1				V
CDKN1A				V
GADD45B				V
MAPKAPK2				V
TRPV4				V
TGFB1				V
SERPINE1				V
+ 4.3 Cellular community - eukaryotes	4.8	3.1	2.1	2.7
+ 04510: Focal adhesion	2.9	2.5	0.1	1
ITGB5	V			V
PPP1R12A	V	V	V	V
PPP1R12C	V	V
PDPK1	V	V
COL6A1	V
COL6A2	V
FN1	V	V		V
XIAP	V
MAPK1	V
RAF1	V
HRAS	V
EGFR	V
ERBB2	V	V
MET	V			V
PDGFRB	V			V
PGF	V	V
VEGFA	V	V	V	V
BCAR1	V	V
RAP1A	V	V
PAK4	V		V
RAC1	V			V
GSK3B	V
ITGB1		V	V
ITGB4		V	V
FLNB		V	V	V
CDC42		V	V
PPP1CA		V		V
ILK		V
PIK3CB		V
SPP1		V		V
IGF1R		V	V
SHC1		V
RAP1B		V	V
MAPK9		V
MYL9			V
DIAPH1			V
PTK2			V
SRC			V
CTNNB1			V
ITGA2				V
AKT1				V
LAMB1				V
RELN				V
JUN				V
+ 04520: Adherens junction	4	1.1	1.8	2.1
CDH1	V	V
CTNND1	V			V
TCF7L2	V
MAPK1	V
TGFBR1	V
EGFR	V
ERBB2	V	V
MET	V			V
INSR	V			V
PTPN6	V
PTPRF	V			V
RAC1	V			V
TJP1	V		V	V
FARP2	V
IGF1R		V	V
CSNK2B		V	V
BAIAP2		V
CDC42		V	V
CTNNA1			V
FER			V	V
CSNK2A1			V
SSX2IP			V
CTNNB1			V
SRC			V
PARD3			V
TCF7				V
CREBBP				V
+ 04530: Tight junction	1.3	2.4	1.3	0.8
TJP1	V		V	V
RAC1	V			V
RAP1A	V	V
MAP2K7	V	V	V
YBX3	V			V
MARVELD3	V
MARVELD2	V		V
PRKAA1	V	V	V	V
PRKAA2	V
TUBA4A	V
ERBB2	V	V
AMOT	V
SCRIB	V	V		V
CDC42		V	V
ARHGEF18		V
F11R		V
PPP2R1B		V	V
MAPK9		V
RDX		V	V
CLDN4		V	V
CLDN14		V
PRKAB2		V
PRKAG1		V	V
TJP2		V
ITGB1		V	V
MYH10		V
PARD3			V
PRKACB			V
SRC			V
LLGL2			V
TUBA1A			V
ACTR3B			V
PCNA			V
CTTN			V
MYL9			V
TJAP1			V
PPP2R2D				V
CLDN6				V
ARHGEF2				V
JUN				V
MYL6B				V
MYH14				V
NEDD4L				V
+ 04540: Gap junction	1.8	0.3	0.7	0.4
MAP3K2	V		V
TJP1	V		V	V
TUBA4A	V
MAPK1	V
RAF1	V
HRAS	V
EGFR	V
PDGFRB	V			V
GNAS	V
GNAI1		V	V
GNAI2		V
TUBB2B		V	V
TUBB1		V
PRKACB			V
TUBB			V	V
ADCY7			V
SRC			V
TUBA1A			V
ADCY9				V
GNA11				V
+ 04550: Signaling pathways regulating pluripotency of stem cells	0.8	0.7	0.8	1.6
AXIN1	V			V
AXIN2	V			V
GSK3B	V
MAPK1	V
HRAS	V
RAF1	V
FGFR3	V		V
MAPK14	V			V
TCF3	V
IL6ST		V	V
PIK3CB		V
BMP4		V		V
IGF1R		V	V
MYC		V	V
SETDB1		V
JARID2		V	V
PCGF2		V	V
PCGF5		V
CTNNB1			V
ACVR1B			V
ACVR1			V	V
FGFR4			V	V
SMAD5			V
REST			V
RIF1			V	V
PCGF6			V
TCF7				V
LIF				V
AKT1				V
INHBE				V
ID2				V
DUSP9				V
+ 4.5 Cell motility	2.4	1.2	0.4	1.2
+ 04810: Regulation of actin cytoskeleton	2.4	1.2	0.4	1.2
ARPC2	V
PFN1	V
SPATA13	V			V
CYFIP1	V	V	V	V
PIP4K2C	V	V	V	V
PIP5K1A	V		V
PIP4K2B	V			V
PPP1R12A	V	V	V	V
PPP1R12C	V	V
PAK4	V		V
RAC1	V			V
MAPK1	V
RAF1	V
BCAR1	V	V
ITGB5	V			V
FN1	V	V		V
MRAS	V
HRAS	V
EGFR	V
FGFR3	V		V
PDGFRB	V			V
BAIAP2		V
RDX		V	V
PPP1CA		V		V
CDC42		V	V
ARHGEF1		V	V
PIK3CB		V
ITGB1		V	V
ITGB2		V	V	V
ITGB4		V	V
MYH10		V
SSH1			V	V
DIAPH1			V
MYL9			V
PTK2			V
SRC			V
ITGAL			V
FGFR4			V	V
F2				V
GSN				V
ITGA2				V
MYH14				V
+ 5. Organismal Systems	10.2	4.9	4.9	7
+ 5.1 Immune system	6.3	2.6	1.7	2.9
+ 04640: Hematopoietic cell lineage	0.1	0.1	0	0.3
CD55	V	V		V
IL4R	V
CD22	V
CD59		V
CSF3R		V	V
CD24			V
ITGA2				V
IL11RA				V
TFRC				V
CSF1				V
+ 04610: Complement and coagulation cascades	2.3	1.2	0.7	3.5
C1R	V			V
C3	V			V
CD46	V		V	V
CD55	V	V		V
PROS1	V	V	V
SERPINA1	V	V	V	V
C4B	V
C4B_2	V
C2	V	V	V
CFD	V
F12		V	V
CD59		V
ITGB2		V	V	V
C5			V	V
CFI			V
F10				V
SERPINE1				V
MASP1				V
C8B				V
C4BPA				V
F2				V
SERPINF2				V
+ 04611: Platelet activation	0.2	1.2	0.1	0.6
RAP1A	V	V
MAPK14	V			V
MAPK1	V
PPP1R12A	V	V	V	V
GNAS	V
ITGB1		V	V
RAP1B		V	V
PIK3CB		V
ARHGEF1		V	V
PPP1CA		V		V
GNAI1		V	V
GNAI2		V
SNAP23		V
ADCY7			V
PRKACB			V
SRC			V
ITGA2				V
AKT1				V
ADCY9				V
STIM1				V
F2				V
+ 04620: Toll-like receptor signaling pathway	2	0.7	0.4	0.7
IRAK1	V	V
MAPK1	V
MAPK14	V			V
RAC1	V			V
IRF3	V
LY96	V
TMED7-TICAM2	V			V
TICAM2	V
MAP2K7	V	V	V
RELA	V
MAP2K3	V
MYD88		V	V
SPP1		V		V
MAPK9		V
PIK3CB		V
IFNAR2		V
IRAK4			V	V
TRAF3			V
IKBKE			V
STAT1			V
IKBKG			V
CASP8			V
MAP2K6			V
AKT1				V
JUN				V
+ 04621: NOD-like receptor signaling pathway	0.9	0.4	0.4	0.2
HSP90AA1	V			V
MAPK1	V
MAPK14	V			V
RELA	V
IRF3	V
MAVS	V	V
VDAC2	V
ERBIN	V	V
XIAP	V
ATG16L1	V
ATG12	V
NLRX1	V			V
HSP90AB1		V
MAPK9		V
MYD88		V	V
IFNAR2		V
BRCC3		V	V
ATG5		V	V
TNFAIP3		V	V
MFN2		V
TRPM7			V
IKBKG			V
TRAF3			V
IKBKE			V
IRAK4			V	V
STAT1			V
STAT2			V
TANK			V
CASP8			V
DNM1L			V
OAS1			V
JUN				V
RNF31				V
GABARAPL1				V
BCL2L1				V
CTSB				V
+ 04622: RIG-I-like receptor signaling pathway	1.6	0.8	1.2	0.2
MAVS	V	V
RELA	V
IRF3	V
AZI2	V	V	V
ATG12	V
NLRX1	V			V
MAPK14	V			V
OTUD5		V	V
ATG5		V	V
MAPK9		V
TRAF3			V
IKBKE			V
TANK			V
CASP8			V
IKBKG			V
TKFC			V
SIKE1				V
+ 04623: Cytosolic DNA-sensing pathway	1.4	1.3	1.2	0.1
IRF3	V
MAVS	V	V
RELA	V
POLR2E	V	V	V	V
POLR2H	V	V	V
POLR1C	V
ADAR		V	V
POLR3H		V	V
POLR1D		V
IKBKE			V
IKBKG			V
POLR3C			V
POLR2L			V
POLR3D				V
+ 04625: C-type lectin receptor signaling pathway	2.3	0	0.6	0.9
RAF1	V
MRAS	V
HRAS	V
RELA	V
MAPK1	V
NFATC3	V		V	V
PPP3CC	V
NFKB2	V			V
CALM1	V		V
CALM2	V		V
CALM3	V		V
MAPK14	V			V
PIK3CB		V
MAPK9		V
SRC			V
IKBKG			V
CASP8			V
IKBKE			V
STAT1			V
STAT2			V
LSP1				V
MAPKAPK2				V
MALT1				V
AKT1				V
JUN				V
+ 04650: Natural killer cell mediated cytotoxicity	0.7	0.2	0	0.1
PPP3CC	V
PTPN6	V
HLA-B	V			V
HLA-A	V	V		V
MAPK1	V
RAF1	V
HRAS	V
RAC1	V			V
IFNGR2		V	V	V
PIK3CB		V
SHC1		V
IFNAR2		V
ITGB2		V	V	V
TNFSF10			V
PLCG1			V
ICAM2			V
ITGAL			V
+ 04612: Antigen processing and presentation	1.4	0.6	0.8	0.6
TAPBP	V	V		V
HLA-A	V	V		V
HLA-B	V			V
CANX	V		V
HSP90AA1	V			V
HSPA1A	V
HSPA1B	V
NFYB		V	V
LGMN		V	V
HSP90AB1		V
NFYA			V
NFYC			V
IFI30			V
TAP1			V
PSME3			V
CTSB				V
+ 04660: T cell receptor signaling pathway	2.4	0.5	0.2	0.3
RELA	V
PDPK1	V	V
HRAS	V
NFATC3	V		V	V
PPP3CC	V
PAK4	V		V
PTPN6	V
RAF1	V
MAPK1	V
MAP2K7	V	V	V
MAPK14	V			V
GSK3B	V
PIK3CB		V
CDC42		V	V
NCK2		V	V
MAPK9		V
IKBKG			V
PLCG1			V
AKT1				V
MALT1				V
JUN				V
+ 04658: Th1 and Th2 cell differentiation	1.7	0.2	0.2	0.6
RELA	V
NFATC3	V		V	V
PPP3CC	V
MAPK1	V
MAPK14	V			V
IL4R	V
STAT6	V	V		V
STAT5A	V	V	V
RBPJ	V			V
MAPK9		V
IFNGR2		V	V	V
IKBKG			V
PLCG1			V
STAT1			V
JUN				V
+ 04659: Th17 cell differentiation	2.3	0.7	0.2	1.2
RELA	V
NFATC3	V		V	V
PPP3CC	V
MAPK1	V
MAPK14	V			V
IL4R	V
STAT6	V	V		V
STAT5A	V	V	V
IL1RAP	V			V
TGFBR1	V
HSP90AA1	V			V
HIF1A	V	V	V	V
MAPK9		V
IFNGR2		V	V	V
IL6ST		V	V
HSP90AB1		V
IKBKG			V
PLCG1			V
STAT1			V
JUN				V
TGFB1				V
+ 04657: IL-17 signaling pathway	1	0.2	0.1	1.2
RELA	V
JUND	V			V
IL17RC	V	V		V
HSP90AA1	V			V
MAPK14	V			V
MAPK1	V
GSK3B	V
HSP90AB1		V
MAPK9		V
TNFAIP3		V	V
IKBKG			V
TRAF3			V
IKBKE			V
CASP8			V
JUN				V
IL17RA				V
ELAVL1				V
CEBPB				V
+ 04662: B cell receptor signaling pathway	2.7	0	0	1.1
RELA	V
GSK3B	V
INPPL1	V			V
HRAS	V
NFATC3	V		V	V
PPP3CC	V
RAC1	V			V
PTPN6	V
CD22	V
MAPK1	V
RAF1	V
PIK3CB		V
IKBKG			V
MALT1				V
AKT1				V
JUN				V
PIK3AP1				V
+ 04664: Fc epsilon RI signaling pathway	2	0.5	0.1	0.2
MAPK14	V			V
MAP2K7	V	V	V
MAP2K3	V
PDPK1	V	V
MAPK1	V
RAF1	V
HRAS	V
RAC1	V			V
PIK3CB		V
MAPK9		V
MAP2K6			V
PLCG1			V
AKT1				V
+ 04666: Fc gamma R-mediated phagocytosis	2.3	0.2	0.3	0.6
INPPL1	V			V
RAF1	V
MAPK1	V
RAC1	V			V
ARPC2	V
ASAP1	V
ASAP3	V			V
ASAP2	V			V
PIP5K1A	V		V
SPHK2	V	V	V
SPHK1	V
PIK3CB		V
RPS6KB1		V	V
CDC42		V	V
PLCG1			V
PLD1			V
DNM2			V
AKT1				V
GSN				V
+ 04670: Leukocyte transendothelial migration	0.3	2.3	1.1	0.2
CTNND1	V			V
BCAR1	V	V
MAPK14	V			V
RAC1	V			V
RAP1A	V	V
CLDN4		V	V
CLDN14		V
CD99		V	V
ITGB2		V	V	V
F11R		V
ITGB1		V	V
PIK3CB		V
RAP1B		V	V
GNAI1		V	V
GNAI2		V
CDC42		V	V
ITGAL			V
CTNNB1			V
MYL9			V
PTK2			V
CTNNA1			V
PLCG1			V
CLDN6				V
+ 04672: Intestinal immune network for IgA production	0	0.1	0.1	0.2
LTBR		V		V
LOC102723996			V
ICOSLG			V
TGFB1				V
+ 04062: Chemokine signaling pathway	0.4	0.3	0.1	0
GNB1	V		V	V
BCAR1	V	V
ARRB2	V			V
RAP1A	V	V
MAPK1	V
HRAS	V
RAF1	V
RAC1	V			V
RELA	V
GSK3B	V
CCL16		V	V
PIK3CB		V
SHC1		V
GNAI1		V	V
GNAI2		V
GRK6		V
CDC42		V	V
RAP1B		V	V
PTK2			V
SRC			V
ADCY7			V
PARD3			V
PRKACB			V
STAT1			V
STAT2			V
IKBKG			V
CXCL16				V
CX3CL1				V
ADCY9				V
AKT1				V
+ 5.2 Endocrine system	8.3	3.8	3.4	4.8
+ 04911: Insulin secretion	0.8	0	0.2	1
GNAS	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
ATP1A1	V		V
VAMP2	V			V
ADCY7			V
PRKACB			V
ATF4			V
ADCY9				V
GNA11				V
KCNMB3				V
+ 04910: Insulin signaling pathway	3	1.5	0.4	1.1
INPPL1	V			V
PTPRF	V			V
MAPK1	V
PRKAA1	V	V	V	V
PRKAA2	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
PRKAR1A	V			V
ACACA	V			V
HRAS	V
TRIP10	V
INSR	V			V
RAF1	V
PCK2	V	V		V
GSK3B	V
PDPK1	V	V
MAPK9		V
PRKAB2		V
PRKAG1		V	V
PPP1CA		V		V
SHC1		V
RPS6KB1		V	V
G6PC		V
PIK3CB		V
FLOT1		V
PHKA1			V
PRKACB			V
PRKAR1B			V
EIF4E2			V
G6PC3			V
EXOC7			V
PHKA2				V
AKT1				V
HK2				V
+ 04922: Glucagon signaling pathway	3.6	1.6	1.4	1.8
PDHA1	V	V	V	V
PDHB	V		V
PKM	V	V
GNAS	V
ATF2	V			V
CREB3L3	V		V	V
PPP4C	V	V
PCK2	V	V		V
CALM1	V		V
CALM2	V		V
CALM3	V		V
PPP3CC	V
ACACA	V			V
PRKAA1	V	V	V	V
PRKAA2	V
LDHA	V	V		V
G6PC		V
PRKAB2		V
PRKAG1		V	V
PPARA		V	V
PRKACB			V
ATF4			V
G6PC3			V
PHKA1			V
PPP4R3A				V
CREBBP				V
AKT1				V
PHKA2				V
+ 04923: Regulation of lipolysis in adipocytes	0.2	0.8	0.8	0.4
GNAS	V
INSR	V			V
PNPLA2		V	V
GNAI1		V	V
GNAI2		V
PIK3CB		V
ADCY7			V
PRKACB			V
PLIN1			V
MGLL			V
ADCY9				V
AKT1				V
+ 04920: Adipocytokine signaling pathway	1.6	2.6	1.3	1.4
RELA	V
PCK2	V	V		V
ACSL1	V	V	V	V
ACSL5	V			V
PRKAA1	V	V	V	V
PRKAA2	V
CAMKK2	V	V	V	V
G6PC		V
PRKAB2		V
PRKAG1		V	V
PPARA		V	V
ADIPOR1		V	V
MAPK9		V
G6PC3			V
ACSBG1			V
IKBKG			V
ADIPOR2				V
AKT1				V
+ 03320: PPAR signaling pathway	1.8	1.7	1.7	2.7
PCK2	V	V		V
ACADM	V	V
ACSL1	V	V	V	V
ACSL5	V			V
ANGPTL4	V			V
PDPK1	V	V
NR1H3	V			V
APOA1	V			V
PPARA		V	V
CYP7A1		V	V
ILK		V
APOA5		V	V
PLIN1			V
SLC27A2			V
SCP2			V	V
EHHADH			V
ACSBG1			V
HMGCS2			V
ACOX2			V
GK				V
PLIN2				V
PPARG				V
ACAA1				V
+ 04912: GnRH signaling pathway	2.6	0.1	1.9	0.2
MAP2K3	V
MAPK14	V			V
MAP3K2	V		V
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNAS	V
MAPK1	V
RAF1	V
HRAS	V
EGFR	V
MAP2K7	V	V	V
CDC42		V	V
MAPK9		V
ADCY7			V
ATF4			V
MAP2K6			V
MAP3K3			V
MAP3K4			V
PLD1			V
SRC			V
PRKACB			V
ADCY9				V
GNA11				V
JUN				V
+ 04913: Ovarian steroidogenesis	1	0.2	0.4	1.7
AKR1C3	V			V
GNAS	V
INSR	V			V
LDLR	V		V	V
ACOT2		V
IGF1R		V	V
ADCY7			V
PRKACB			V
STAR				V
ADCY9				V
SCARB1				V
+ 04915: Estrogen signaling pathway	3	0.9	0.2	0.4
EGFR	V
SP1	V	V
HRAS	V
RAF1	V
MAPK1	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
HSP90AA1	V			V
HSPA1A	V
HSPA1B	V
GNAS	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
EBAG9	V
TGFA	V
PIK3CB		V
SHC1		V
HSP90AB1		V
GNAI1		V	V
GNAI2		V
NCOA2		V
NCOA3		V
NCOA1		V
SRC			V
PRKACB			V
ATF4			V
ADCY7			V
JUN				V
ADCY9				V
AKT1				V
CTSD				V
+ 04914: Progesterone-mediated oocyte maturation	1.9	2.2	1.6	0.8
CPEB4	V
ANAPC11	V		V	V
CDC25B	V	V
HSP90AA1	V			V
RPS6KA3	V
MAPK1	V
CDK2	V
AURKA	V	V	V
MAPK14	V			V
RAF1	V
IGF1R		V	V
PIK3CB		V
ANAPC13		V	V
ANAPC2		V	V
CDC16		V	V	V
HSP90AB1		V
GNAI1		V	V
GNAI2		V
MAPK9		V
ADCY7			V
CCNB1			V
ANAPC4			V
CDC27			V
CDC25C			V
PRKACB			V
ADCY9				V
AKT1				V
FZR1				V
+ 04917: Prolactin signaling pathway	2.3	0.5	0.1	0.2
MAPK1	V
RAF1	V
HRAS	V
PRLR	V			V
STAT5A	V	V	V
MAPK14	V			V
GALT	V
GSK3B	V
RELA	V
PIK3CB		V
SHC1		V
MAPK9		V
STAT1			V
SRC			V
SOCS7			V
AKT1				V
+ 04921: Oxytocin signaling pathway	2.1	0.5	0.4	0.6
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNAS	V
HRAS	V
RAF1	V
MAPK1	V
PPP1R12A	V	V	V	V
PPP1R12C	V	V
CAMKK2	V	V	V	V
PRKAA1	V	V	V	V
PRKAA2	V
PPP3CC	V
NFATC3	V		V	V
EGFR	V
PPP1CA		V		V
PRKAB2		V
PRKAG1		V	V
GNAI1		V	V
GNAI2		V
ADCY7			V
PRKACB			V
MYL9			V
SRC			V
ADCY9				V
CAMK1				V
MYL6B				V
JUN				V
CDKN1A				V
+ 04926: Relaxin signaling pathway	2.6	0.6	0.3	1.2
RELA	V
MAPK1	V
GNB1	V		V	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
GNAS	V
VEGFA	V	V	V	V
HRAS	V
RAF1	V
TGFBR1	V
MAP2K7	V	V	V
MAPK14	V			V
EGFR	V
ARRB2	V			V
PIK3CB		V
GNAI1		V	V
GNAI2		V
SHC1		V
MAPK9		V
ATF4			V
PRKACB			V
ADCY7			V
SRC			V
AKT1				V
TGFB1				V
ADCY9				V
JUN				V
+ 04918: Thyroid hormone synthesis	1.5	0.4	1.1	1.6
GNAS	V
ATP1A1	V		V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
CANX	V		V
GSR	V	V		V
TTF1		V	V
GPX1		V
PRKACB			V
ADCY7			V
ATF4			V
GPX7			V
ADCY9				V
PDIA4				V
ASGR2				V
SERPINA7				V
+ 04919: Thyroid hormone signaling pathway	1.4	2.2	0.7	0.5
PDPK1	V	V
GSK3B	V
HRAS	V
RAF1	V
HIF1A	V	V	V	V
MAPK1	V
ATP1A1	V		V
SIN3A	V	V		V
HDAC2	V
MED16	V			V
PIK3CB		V
THRA		V
THRB		V
ATP2A2		V
TP53		V	V
NCOA2		V
NCOA3		V
NCOA1		V
BMP4		V		V
MYC		V	V
CTNNB1			V
PLCG1			V
STAT1			V
PRKACB			V
DIO1			V
MED14			V
MED17			V
SRC			V
AKT1				V
PLCD3				V
CREBBP				V
+ 04928: Parathyroid hormone synthesis, secretion and action	2	1	0.4	1.5
GNAS	V
ARRB2	V			V
RAF1	V
MAPK1	V
EGFR	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
JUND	V			V
MEF2D	V
SP1	V	V
GNAI1		V	V
GNAI2		V
PDE4D		V
ARHGEF1		V	V
ARHGEF11		V	V
LRP5		V		V
ADCY7			V
PRKACB			V
PLD1			V
ATF4			V
GNA11				V
ADCY9				V
CYP24A1				V
CDKN1A				V
+ 04916: Melanogenesis	1.8	0	0.3	0.1
CALM1	V		V
CALM2	V		V
CALM3	V		V
TCF7L2	V
GNAS	V
CREB3L3	V		V	V
GSK3B	V
MAPK1	V
RAF1	V
HRAS	V
GNAI1		V	V
GNAI2		V
PRKACB			V
ADCY7			V
CTNNB1			V
CREBBP				V
TCF7				V
ADCY9				V
+ 04924: Renin secretion	0.9	0.1	0.3	0
GNAS	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
PPP3CC	V
GNAI1		V	V
GNAI2		V
PRKACB			V
CTSB				V
+ 04614: Renin-angiotensin system	0.3	0.3	0.1	0.3
CTSA	V	V	V	V
+ 04925: Aldosterone synthesis and secretion	1.9	0.1	1.5	1.7
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNAS	V
NR4A1	V			V
LDLR	V		V	V
ATP1A1	V		V
PRKD2		V	V
DAGLA		V
ATF4			V
ADCY7			V
PRKD3			V
PRKACB			V
ATP2B4			V
GNA11				V
ADCY9				V
CAMK1				V
STAR				V
SCARB1				V
+ 04927: Cortisol synthesis and secretion	2.1	0.1	0.5	2.6
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
GNAS	V
LDLR	V		V	V
NCEH1	V			V
NR4A1	V			V
SP1	V	V
ATF4			V
ADCY7			V
PRKACB			V
GNA11				V
ADCY9				V
STAR				V
SCARB1				V
+ 5.3 Circulatory system	1.1	0.4	0.7	0.9
+ 04260: Cardiac muscle contraction	0.1	0.1	0	0.1
TPM3	V	V		V
ATP1A1	V		V
ASPH	V	V
ATP2A2		V
TPM1			V
TPM2			V
TPM4				V
COX6C				V
+ 04261: Adrenergic signaling in cardiomyocytes	1.1	0.4	1	1.2
TPM3	V	V		V
ATP1A1	V		V
GNAS	V
MAPK1	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
MAPK14	V			V
ATP2A2		V
GNAI1		V	V
GNAI2		V
PPP1CA		V		V
PPP2R1B		V	V
PPP2R5C		V	V
TPM1			V
TPM2			V
ADCY7			V
PRKACB			V
ATF4			V
PPP2R5E			V	V
ATP2B4			V
TPM4				V
ADCY9				V
AKT1				V
PPP2R5B				V
PPP2R2D				V
+ 04270: Vascular smooth muscle contraction	0.7	0.1	0.2	0.3
PPP1R12A	V	V	V	V
PPP1R12C	V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
RAF1	V
MAPK1	V
GNAS	V
PPP1CA		V		V
ARHGEF1		V	V
ARHGEF11		V	V
MYL9			V
CALD1			V
ADCY7			V
PRKACB			V
MYL6B				V
GNA11				V
KCNMB3				V
PLA2G2A				V
ADCY9				V
+ 5.4 Digestive system	2.5	0.9	1.8	3.5
+ 04970: Salivary secretion	0.8	0	0.5	0.1
GNAS	V
VAMP2	V			V
CALM1	V		V
CALM2	V		V
CALM3	V		V
ATP1A1	V		V
CST3		V	V
ADCY7			V
PRKACB			V
ATP2B4			V
ADCY9				V
SLC4A2				V
+ 04971: Gastric acid secretion	0.7	0.1	0.6	0.1
GNAS	V
ATP1A1	V		V
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNAI1		V	V
GNAI2		V
ADCY7			V
PRKACB			V
ADCY9				V
SLC4A2				V
+ 04972: Pancreatic secretion	0.2	0.1	0	0.2
ATP1A1	V		V
GNAS	V
RAP1A	V	V
RAC1	V			V
ATP2A2		V
RAP1B		V	V
ATP2B4			V
ADCY7			V
SLC4A2				V
PLA2G2A				V
ADCY9				V
+ 04976: Bile secretion	1.5	0.2	0.9	2.1
ATP1A1	V		V
GNAS	V
ABCC2	V
ABCB4	V
LDLR	V		V	V
HMGCR	V			V
NCEH1	V			V
CYP7A1		V	V
NR1H4		V	V	V
SLC22A7		V	V	V
ADCY7			V
PRKACB			V
ABCC3			V
SLC4A2				V
ADCY9				V
SLC51B				V
SCARB1				V
+ 04973: Carbohydrate digestion and absorption	0.1	0.7	0.3	0.6
ATP1A1	V		V
SLC37A4		V	V	V
G6PC		V
PIK3CB		V
G6PC3			V
HK2				V
AKT1				V
+ 04974: Protein digestion and absorption	0.5	0	0	0.1
ATP1A1	V		V
COL6A1	V
COL6A2	V
COL7A1	V			V
COL27A1	V			V
SLC38A2				V
+ 04975: Fat digestion and absorption	0.1	0.8	0.7	1.6
APOA1	V			V
DGAT1		V	V
MTTP		V	V
ABCA1		V
NPC1L1			V	V
AGPAT1			V
APOB				V
PLA2G2A				V
SCARB1				V
+ 04979: Cholesterol metabolism	1.9	0.6	0.7	3.4
APOA1	V			V
ANGPTL4	V			V
NCEH1	V			V
LDLR	V		V	V
LCAT	V			V
VDAC2	V
ABCA1		V
LIPC		V	V
CYP7A1		V	V
SOAT1			V
SOAT2			V
APOB				V
ANGPTL8				V
SCARB1				V
SORT1				V
STAR				V
+ 04977: Vitamin digestion and absorption	1.4	0.3	0.9	1.9
APOA1	V			V
SLC19A1	V			V
SLC46A1	V		V
ABCC1		V	V
BTD			V
APOB				V
SCARB1				V
+ 04978: Mineral absorption	0.5	0.2	1.2	1.1
SLC46A1	V		V
SLC26A6	V		V	V
ATP1A1	V		V
SLC11A2		V	V
HMOX2		V	V	V
STEAP1			V
TRPM7			V
SLC39A4				V
MT1X				V
MT2A				V
+ 5.5 Excretory system	2.9	0.9	1.4	2.2
+ 04962: Vasopressin-regulated water reabsorption	1.6	1.1	0.8	2.3
GNAS	V
CREB3L3	V		V	V
STX4	V	V	V
VAMP2	V			V
DCTN4	V			V
ARHGDIA		V	V	V
RAB5B		V
DYNC1LI2		V
PRKACB			V
DCTN5			V
ADCY9				V
AQP3				V
DYNC1I2				V
+ 04960: Aldosterone-regulated sodium reabsorption	1.4	0.4	0	0.8
ATP1A1	V		V
INSR	V			V
PDPK1	V	V
MAPK1	V
PIK3CB		V
NEDD4L				V
SLC9A3R2				V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	1.4	0.2	1	0.8
AP2M1	V		V
AP2S1	V	V		V
AP2A2	V	V	V	V
GNAS	V
ATP1A1	V		V
AP2B1			V
DNM2			V
PRKACB			V
CLTB				V
ADCY9				V
+ 04964: Proximal tubule bicarbonate reclamation	2	0.3	1.4	0.8
ATP1A1	V		V
SLC25A10	V		V	V
MDH1	V		V
PCK2	V	V		V
GLS2			V
+ 04966: Collecting duct acid secretion	0.2	0	0	0.2
ATP6V0A1	V
ATP6V0C				V
+ 5.6 Nervous system	3.2	1.4	1.2	1.6
+ 04724: Glutamatergic synapse	0.1	0	0	0.2
GNAS	V
GNB1	V		V	V
PPP3CC	V
MAPK1	V
SLC38A1		V		V
GNAI1		V	V
GNAI2		V
ADCY7			V
PRKACB			V
GLS2			V
PLD1			V
ADCY9				V
SLC38A2				V
GLUL				V
+ 04727: GABAergic synapse	0	0.1	0.3	0.7
GNB1	V		V	V
GNAI1		V	V
GNAI2		V
SLC38A1		V		V
ADCY7			V
GLS2			V
PRKACB			V
TRAK2			V
SRC			V
ADCY9				V
GLUL				V
GABARAPL1				V
SLC38A2				V
+ 04725: Cholinergic synapse	0.1	0	0	0.2
GNB1	V		V	V
MAPK1	V
CREB3L3	V		V	V
HRAS	V
GNAI1		V	V
GNAI2		V
PIK3CB		V
ADCY7			V
PRKACB			V
ATF4			V
ADCY9				V
GNA11				V
AKT1				V
+ 04728: Dopaminergic synapse	1.7	0.6	0.9	1.5
GNAS	V
GNB1	V		V	V
GSK3B	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
MAPK14	V			V
PPP3CC	V
ARRB2	V			V
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNAI1		V	V
GNAI2		V
MAPK9		V
PPP2R1B		V	V
PPP2R5C		V	V
PPP1CA		V		V
CLOCK		V
PRKACB			V
DDC			V
ATF4			V
COMT			V	V
PPP2R5E			V	V
AKT1				V
PPP2R5B				V
PPP2R2D				V
+ 04726: Serotonergic synapse	0.2	0.1	0	0
GNAS	V
GNB1	V		V	V
MAPK1	V
HRAS	V
RAF1	V
GNAI1		V	V
GNAI2		V
CYP2D6		V
APP		V		V
PRKACB			V
DDC			V
DUSP1				V
+ 04720: Long-term potentiation	2.4	0.3	0.5	0.1
PPP3CC	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
RPS6KA3	V
MAPK1	V
RAF1	V
HRAS	V
RAP1A	V	V
PPP1CA		V		V
RAP1B		V	V
ATF4			V
PRKACB			V
CREBBP				V
+ 04730: Long-term depression	0.7	0.6	0.1	0
GNAS	V
MAPK1	V
RAF1	V
HRAS	V
GNAI1		V	V
GNAI2		V
IGF1R		V	V
PPP2R1B		V	V
GNA11				V
+ 04723: Retrograde endocannabinoid signaling	0.2	0.1	0.3	0.2
GNB1	V		V	V
MAPK14	V			V
MAPK1	V
NDUFA11	V			V
NDUFS7	V			V
NDUFB3	V		V	V
GNAI1		V	V
GNAI2		V
DAGLA		V
MAPK9		V
NDUFC1		V	V
NDUFS2		V	V	V
MGLL			V
ADCY7			V
PRKACB			V
NDUFA2			V
NDUFA7			V
NDUFB2			V
NDUFA12			V
ADCY9				V
+ 04721: Synaptic vesicle cycle	1	0.2	0.3	0.9
VAMP2	V			V
AP2M1	V		V
AP2S1	V	V		V
AP2A2	V	V	V	V
ATP6V0B	V		V	V
ATP6V0A1	V
SLC6A9		V	V
AP2B1			V
DNM2			V
CLTB				V
ATP6V0C				V
+ 04722: Neurotrophin signaling pathway	3.7	2.4	1.2	1.2
HRAS	V
RAF1	V
MAPK1	V
RPS6KA3	V
RAP1A	V	V
GSK3B	V
RELA	V
PDPK1	V	V
MAPK14	V			V
MAP2K7	V	V	V
RAC1	V			V
MAGED1	V	V	V	V
IRAK1	V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
PSEN1	V			V
PSEN2	V
PIK3CB		V
SHC1		V
RAP1B		V	V
MAPK9		V
TP53		V	V
ARHGDIA		V	V	V
CDC42		V	V
ZNF274		V
BAX		V
PLCG1			V
ATF4			V
MAP3K3			V
SH2B1			V
IRAK4			V	V
AKT1				V
SORT1				V
JUN				V
MAPKAPK2				V
+ 5.7 Sensory system	1.3	0	0.7	0.5
+ 04744: Phototransduction	1.8	0	1.2	0.6
GNB1	V		V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
CNGB1				V
+ 04740: Olfactory transduction	0	0	0	0
GNB1	V		V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
ARRB2	V			V
PRKACB			V
CNGB1				V
+ 04742: Taste transduction	0	0	0	0
PRKACB			V
ENTPD2				V
+ 04750: Inflammatory mediator regulation of TRP channels	0.9	0.1	0.3	0.3
IL1RAP	V			V
GNAS	V
MAPK14	V			V
CALM1	V		V
CALM2	V		V
CALM3	V		V
MAP2K3	V
MAPK9		V
PIK3CB		V
PPP1CA		V		V
ADCY7			V
PRKACB			V
PLCG1			V
SRC			V
MAP2K6			V
ADCY9				V
TRPV4				V
+ 5.8 Development and regeneration	1.5	0.6	0.4	1.4
+ 04360: Axon guidance	1.1	0.8	0.6	0.3
MAPK1	V
RAC1	V			V
NFATC3	V		V	V
PPP3CC	V
PAK4	V		V
MET	V			V
SEMA3B	V	V		V
SEMA4B	V
SRGAP2	V		V	V
HRAS	V
GSK3B	V
FES	V		V	V
RAF1	V
GNAI1		V	V
GNAI2		V
CDC42		V	V
ITGB1		V	V
ROBO1		V	V
NGEF		V
EFNA2		V
SEMA6B		V	V
NCK2		V	V
ILK		V
PIK3CB		V
PARD3			V
PTK2			V
PLXNA3			V
SRC			V
SSH1			V	V
PLCG1			V
MYL9			V
SEMA4C				V
SEMA4G				V
ABLIM1				V
+ 04380: Osteoclast differentiation	1	0.1	0	1.6
RELA	V
MAPK14	V			V
JUND	V			V
PPP3CC	V
TGFBR1	V
NFKB2	V			V
MAPK1	V
MAP2K7	V	V	V
RAC1	V			V
MAPK9		V
IFNAR2		V
PIK3CB		V
IFNGR2		V	V	V
IKBKG			V
MAP2K6			V
STAT1			V
STAT2			V
CSF1				V
AKT1				V
FOSL2				V
JUN				V
FHL2				V
PPARG				V
TGFB1				V
+ 5.9 Aging	3	3.6	2.7	2.4
+ 04211: Longevity regulating pathway	2.4	3	2.6	2.9
HRAS	V
PRKAA1	V	V	V	V
PRKAA2	V
INSR	V			V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
CAMKK2	V	V	V	V
RELA	V
RB1CC1	V
ATG13	V	V		V
RPS6KB1		V	V
PIK3CB		V
IGF1R		V	V
PRKAB2		V
PRKAG1		V	V
TP53		V	V
ADIPOR1		V	V
BAX		V
ATG5		V	V
PRKACB			V
ADCY7			V
ATF4			V
EIF4E2			V
SESN1			V
EHMT2			V	V
AKT1				V
ADCY9				V
ADIPOR2				V
ULK1				V
PPARG				V
+ 04213: Longevity regulating pathway - multiple species	1.8	2.1	1.2	0.6
HRAS	V
INSR	V			V
PRKAA1	V	V	V	V
PRKAA2	V
HSPA1A	V
HSPA1B	V
HDAC2	V
RPS6KB1		V	V
PIK3CB		V
IGF1R		V	V
FOXA2		V
PRKAB2		V
PRKAG1		V	V
ATG5		V	V
PRKACB			V
ADCY7			V
CRYAB			V
AKT1				V
ADCY9				V
+ 5.10 Environmental adaptation	2.3	1.4	1.4	1.9
+ 04710: Circadian rhythm	1.7	1.6	1	1.5
NPAS2	V			V
BTRC	V		V
PRKAA1	V	V	V	V
PRKAA2	V
CLOCK		V
PRKAB2		V
PRKAG1		V	V
FBXL3			V
NR1D1				V
BHLHE40				V
+ 04713: Circadian entrainment	0.7	0	0.2	0.1
CALM1	V		V
CALM2	V		V
CALM3	V		V
GNB1	V		V	V
MAPK1	V
GNAS	V
GNAI1		V	V
GNAI2		V
ADCY7			V
PRKACB			V
ADCY9				V
RASD1				V
+ 04714: Thermogenesis	1.7	0.8	1.3	1.6
CREB3L3	V		V	V
MAPK14	V			V
GNAS	V
ATF2	V			V
KDM3A	V		V	V
SMARCA2	V			V
SMARCB1	V			V
RPS6KA3	V
HRAS	V
ACSL1	V	V	V	V
ACSL5	V			V
MAP2K3	V
PRKAA1	V	V	V	V
PRKAA2	V
SLC25A29	V	V	V	V
NDUFA11	V			V
NDUFS7	V			V
NDUFB3	V		V	V
ATP5F1A	V		V
ARID1B		V	V
SMARCC2		V	V
SMARCD1		V		V
MLST8		V	V
RPS6KB1		V	V
PNPLA2		V	V
PRKAB2		V
PRKAG1		V	V
NDUFC1		V	V
NDUFS2		V	V	V
ATP5MC2		V
ATP5PF		V
PRKACB			V
ADCY7			V
PLIN1			V
MGLL			V
COX11			V
NDUFA2			V
NDUFA7			V
NDUFB2			V
NDUFA12			V
ATP5MC3			V
ATP5MF			V
ADCY9				V
PPARG				V
SMARCA4				V
COX6C				V
ATP5F1C				V
+ 6. Human Diseases	13	7.9	4.2	6.4
+ 6.1 Cancer: overview	7.9	4.3	2.8	4.5
+ 05200: Pathways in cancer	3.3	2.4	0.5	1.9
CDH1	V	V
FN1	V	V		V
STAT5A	V	V	V
EGFR	V
ERBB2	V	V
PDGFRB	V			V
MET	V			V
FGFR3	V		V
TFG	V	V	V	V
TPM3	V	V		V
TGFA	V
IGF2	V			V
HSP90AA1	V			V
GSK3B	V
AXIN1	V			V
AXIN2	V			V
HRAS	V
RAF1	V
NFKB2	V			V
RELA	V
NCOA4	V		V
RAC1	V			V
TCF7L2	V
HIF1A	V	V	V	V
ARNT	V
MLH1	V	V	V
TGFBR1	V
HDAC2	V
ZBTB17	V
CDK2	V
XIAP	V
PGF	V	V
VEGFA	V	V	V	V
DAPK3	V			V
MAPK1	V
GNAS	V
GNB1	V		V	V
PLEKHG5	V
NFE2L2	V		V	V
GSTT1	V	V	V	V
MGST2	V			V
TXNRD1	V			V
GADD45A	V
SP1	V	V
CALM1	V		V
CALM2	V		V
CALM3	V		V
IL4R	V
STAT6	V	V		V
ITGB1		V	V
PIK3CB		V
IGF1R		V	V
HSP90AB1		V
MAPK9		V
CDC42		V	V
MYC		V	V
TP53		V	V
SUFU		V	V
EGLN2		V
MSH2		V		V
BAX		V
BMP4		V		V
BIRC5		V	V
CSF3R		V	V
LPAR6		V
ARHGEF1		V	V
ARHGEF11		V	V
GNAI1		V	V
GNAI2		V
GSTM4		V	V
MGST1		V	V
TXNRD2		V	V
NCOA3		V
NCOA1		V
LRP5		V		V
EML4		V
RPS6KB1		V	V
CASP7		V	V
IFNAR2		V
IFNGR2		V	V	V
IL6ST		V	V
CTNNB1			V
CTNNA1			V
PTK2			V
FGFR4			V	V
IKBKG			V
STAT1			V
PLCG1			V
PLD1			V
CUL2			V
RAD51			V
PML			V
SKP2			V
CASP8			V
TRAF3			V
ADCY7			V
PRKACB			V
STAT2			V
LAMB1				V
ITGA2				V
BCL2L1				V
JUN				V
TCF7				V
CREBBP				V
TGFB1				V
MSH6				V
PPARG				V
CDKN1A				V
BIRC7				V
AKT1				V
ADCY9				V
GNA11				V
HES1				V
GADD45B				V
PIM1				V
F2				V
+ 05202: Transcriptional misregulation in cancer	0.8	0.7	0	1.3
ETV4	V	V
MET	V			V
NUPR1	V			V
TCF3	V
SIN3A	V	V		V
HMGA2	V		V
SP1	V	V
ZBTB17	V
TAF15	V			V
HDAC2	V
RELA	V
GADD45A	V
FUS		V	V
MYC		V	V
AFF1		V	V
IGF1R		V	V
TP53		V	V
BCL6		V		V
H3F3A		V
H3F3B		V
BAX		V
EWSR1			V
SS18			V
BAIAP3			V	V
PML			V
PTK2			V
DDIT3				V
ID2				V
PPARG				V
CDKN1A				V
CEBPB				V
BCL2L1				V
KLF3				V
KDM6A				V
GADD45B				V
+ 05206: MicroRNAs in cancer	3.2	1	1.6	1.4
CDC25B	V	V
BCL2L2	V			V
VEGFA	V	V	V	V
DNMT3A	V
HMGA2	V		V
MCL1	V		V	V
MET	V			V
PAK4	V		V
EGFR	V
ERBB2	V	V
SLC7A1	V
CCNG1	V
HRAS	V
EZH2	V		V
DICER1	V			V
MAPK1	V
FGFR3	V		V
RAF1	V
PDGFRB	V			V
MYC		V	V
RDX		V	V
ABCC1		V	V
IGF2BP1		V
TP53		V	V
MDM4		V
SHC1		V
BMF		V	V
CDC25C			V
PDCD4			V
TPM1			V
HNRNPK			V	V
RECK			V
GLS2			V
BRCA1			V
PLCG1			V
CREBBP				V
STMN1				V
PIM1				V
ERBB3				V
CYP24A1				V
CDKN1A				V
+ 05205: Proteoglycans in cancer	2.2	2.1	1.3	1.7
ERBB2	V	V
PPP1R12A	V	V	V	V
PPP1R12C	V	V
RAC1	V			V
MAPK1	V
MRAS	V
HRAS	V
RAF1	V
MET	V			V
VEGFA	V	V	V	V
HIF1A	V	V	V	V
PDPK1	V	V
ITGB5	V			V
FN1	V	V		V
IGF2	V			V
MAPK14	V			V
PTPN6	V
EGFR	V
CD63	V		V	V
PIK3CB		V
PPP1CA		V		V
FLNB		V	V	V
CDC42		V	V
ARHGEF1		V	V
TP53		V	V
MYC		V	V
IGF1R		V	V
RPS6KB1		V	V
LUM		V	V
ITGB1		V	V
RDX		V	V
CTTN			V
SRC			V
CTNNB1			V
PTK2			V
DCN			V
PDCD4			V
PLCG1			V
IHH			V
PRKACB			V
AKT1				V
TGFB1				V
ERBB3				V
CDKN1A				V
EIF4B				V
ITGA2				V
+ 05204: Chemical carcinogenesis	0.9	0.1	0.4	1.1
ADH6	V
GSTT1	V	V	V	V
GSTK1	V
MGST2	V			V
KYAT1	V			V
ARNT	V
GSTM4		V	V
MGST1		V	V
UGT2B10			V
ALDH3B1			V
CBR1			V
SULT1A1			V
UGT2A3				V
SULT1A4				V
SULT1A3				V
KYAT3				V
+ 05203: Viral carcinogenesis	4	2	0.8	3
SCRIB	V	V		V
IRF3	V
MAPK1	V
ATF2	V			V
ATF6B	V	V	V	V
CREB3L3	V		V	V
STAT5A	V	V	V
NFKB2	V			V
RELA	V
CDK2	V
USP7	V
RBPJ	V			V
MRPS18B	V
HPN	V			V
HRAS	V
GTF2H1	V
GTF2H4	V		V
DNAJA3	V
PKM	V	V
HDAC2	V
HDAC11	V
RAC1	V			V
GTF2A1	V
CHEK1	V		V	V
C3	V			V
HLA-A	V	V		V
HLA-B	V			V
TP53		V	V
BAX		V
PIK3CB		V
HDAC5		V		V
HDAC10		V		V
CDC42		V	V
IL6ST		V	V
LTBR		V		V
HIST1H2BD		V
HIST1H2BG		V
HIST1H2BF		V
HIST1H2BE		V
HIST1H2BI		V
HIST1H2BC		V
RBL1			V
CHD4			V
CASP8			V
IKBKG			V
TRAF3			V
SRC			V
ATF4			V
SKP2			V
GTF2H2C			V	V
GTF2H2C_2			V	V
HNRNPK			V	V
PRKACB			V
JUN				V
CREBBP				V
CDKN1A				V
GSN				V
MAPKAPK2				V
HIST1H2BN				V
+ 05230: Central carbon metabolism in cancer	4.1	1.9	1.9	1.8
HIF1A	V	V	V	V
PDHA1	V	V	V	V
PDHB	V		V
PKM	V	V
LDHA	V	V		V
EGFR	V
ERBB2	V	V
FGFR3	V		V
MET	V			V
PDGFRB	V			V
HRAS	V
RAF1	V
MAPK1	V
IDH1	V		V	V
MYC		V	V
PIK3CB		V
TP53		V	V
SLC16A3			V
GLS2			V
SIRT3			V
G6PD			V
AKT1				V
HK2				V
+ 05231: Choline metabolism in cancer	2.2	1.7	0.3	0.5
MAPK1	V
HRAS	V
RAF1	V
PDPK1	V	V
EGFR	V
PDGFRB	V			V
LYPLA1	V		V	V
PIP5K1A	V		V
RAC1	V			V
SP1	V	V
HIF1A	V	V	V	V
MAPK9		V
PIK3CB		V
SLC44A2		V	V
CHKA		V
CHKB		V
RPS6KB1		V	V
DGKD		V
PLCG1			V
PCYT1B			V
PLD1			V
AKT1				V
JUN				V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	3	1	1.5	0.9
RELA	V
HRAS	V
NFATC3	V		V	V
PPP3CC	V
PTPN6	V
RAF1	V
MAPK1	V
EGFR	V
MAP2K3	V
MAPK14	V			V
HIF1A	V	V	V	V
TMED7-TICAM2	V			V
TICAM2	V
PIK3CB		V
IFNGR2		V	V	V
CSNK2B		V	V
EML4		V
MYD88		V	V
RPS6KB1		V	V
IKBKG			V
PLCG1			V
STAT1			V
MAP3K3			V
MAP2K6			V
CSNK2A1			V
AKT1				V
JUN				V
+ 6.2 Cancer: specific types	10.1	5.4	1.4	4.7
+ 05210: Colorectal cancer	3.2	1.7	0.2	2.3
TGFBR1	V
MLH1	V	V	V
RAF1	V
AXIN1	V			V
AXIN2	V			V
RAC1	V			V
MAPK1	V
TCF7L2	V
GSK3B	V
GADD45A	V
HRAS	V
EGFR	V
TGFA	V
PIK3CB		V
MSH2		V		V
MAPK9		V
BIRC5		V	V
MYC		V	V
TP53		V	V
BAX		V
RPS6KB1		V	V
CTNNB1			V
TGFB1				V
JUN				V
TCF7				V
AKT1				V
MSH6				V
CDKN1A				V
GADD45B				V
+ 05212: Pancreatic cancer	2.5	1.7	0.8	1.3
ERBB2	V	V
RAC1	V			V
RELA	V
RAF1	V
MAPK1	V
TGFA	V
VEGFA	V	V	V	V
TGFBR1	V
EGFR	V
GADD45A	V
PIK3CB		V
MAPK9		V
CDC42		V	V
RPS6KB1		V	V
TP53		V	V
BAX		V
IKBKG			V
PLD1			V
STAT1			V
RAD51			V
AKT1				V
BCL2L1				V
TGFB1				V
CDKN1A				V
GADD45B				V
+ 05225: Hepatocellular carcinoma	2.8	1.7	0.4	2.5
EGFR	V
HRAS	V
RAF1	V
MAPK1	V
IGF2	V			V
TCF7L2	V
AXIN1	V			V
AXIN2	V			V
GSK3B	V
GADD45A	V
TGFA	V
TGFBR1	V
MET	V			V
SMARCB1	V			V
SMARCA2	V			V
NFE2L2	V		V	V
GSTT1	V	V	V	V
MGST2	V			V
TXNRD1	V			V
SHC1		V
RPS6KB1		V	V
IGF1R		V	V
PIK3CB		V
MYC		V	V
LRP5		V		V
TP53		V	V
BAX		V
ARID1B		V	V
SMARCC2		V	V
GSTM4		V	V
MGST1		V	V
TXNRD2		V	V
SMARCD1		V		V
CSNK1A1			V
CTNNB1			V
PLCG1			V
AKT1				V
TCF7				V
CDKN1A				V
GADD45B				V
TGFB1				V
SMARCA4				V
BCL2L1				V
+ 05226: Gastric cancer	2.2	0.8	0	0.5
HRAS	V
RAF1	V
MAPK1	V
TCF7L2	V
AXIN1	V			V
AXIN2	V			V
GSK3B	V
GADD45A	V
TGFBR1	V
MET	V			V
ERBB2	V	V
CDH1	V	V
CDK2	V
MLH1	V	V	V
EGFR	V
SHC1		V
RPS6KB1		V	V
PIK3CB		V
MYC		V	V
LRP5		V		V
TP53		V	V
BAX		V
CSNK1A1			V
CTNNB1			V
CTNNA1			V
AKT1				V
TCF7				V
CDKN1A				V
GADD45B				V
TGFB1				V
+ 05214: Glioma	2.5	0.7	0.3	0.6
TGFA	V
EGFR	V
PDGFRB	V			V
CALM1	V		V
CALM2	V		V
CALM3	V		V
RAF1	V
MAPK1	V
HRAS	V
GADD45A	V
IGF1R		V	V
SHC1		V
PIK3CB		V
TP53		V	V
BAX		V
PLCG1			V
CAMK1				V
AKT1				V
CDKN1A				V
GADD45B				V
+ 05216: Thyroid cancer	3.2	2.3	1.1	2.2
HRAS	V
MAPK1	V
CDH1	V	V
NCOA4	V		V
TFG	V	V	V	V
TPM3	V	V		V
TCF7L2	V
GADD45A	V
MYC		V	V
TP53		V	V
BAX		V
CTNNB1			V
PPARG				V
TCF7				V
CDKN1A				V
GADD45B				V
+ 05221: Acute myeloid leukemia	1.3	0.5	0.3	0.2
RELA	V
STAT5A	V	V	V
TCF7L2	V
HRAS	V
MAPK1	V
RAF1	V
MYC		V	V
RPS6KB1		V	V
PIK3CB		V
PML			V
IKBKG			V
TCF7				V
PIM1				V
AKT1				V
+ 05220: Chronic myeloid leukemia	1.8	1	0.1	0.6
HDAC2	V
TGFBR1	V
STAT5A	V	V	V
RELA	V
MAPK1	V
RAF1	V
HRAS	V
GADD45A	V
TP53		V	V
MYC		V	V
SHC1		V
PIK3CB		V
BAX		V
IKBKG			V
BCL2L1				V
TGFB1				V
CDKN1A				V
AKT1				V
GADD45B				V
+ 05217: Basal cell carcinoma	1	0.6	0.1	1.2
AXIN1	V			V
AXIN2	V			V
GSK3B	V
TCF7L2	V
GADD45A	V
BMP4		V		V
SUFU		V	V
TP53		V	V
BAX		V
CTNNB1			V
TCF7				V
CDKN1A				V
GADD45B				V
+ 05218: Melanoma	1.9	0.7	0	0.7
CDH1	V	V
EGFR	V
MET	V			V
PDGFRB	V			V
MAPK1	V
RAF1	V
HRAS	V
GADD45A	V
IGF1R		V	V
TP53		V	V
PIK3CB		V
BAX		V
CDKN1A				V
AKT1				V
GADD45B				V
+ 05211: Renal cell carcinoma	3.1	1.5	0.5	2.2
VEGFA	V	V	V	V
ARNT	V
HIF1A	V	V	V	V
TGFA	V
RAC1	V			V
MET	V			V
PAK4	V		V
RAP1A	V	V
MAPK1	V
RAF1	V
HRAS	V
EGLN2		V
RAP1B		V	V
CDC42		V	V
PIK3CB		V
CUL2			V
TGFB1				V
CREBBP				V
AKT1				V
JUN				V
CDKN1A				V
+ 05219: Bladder cancer	3.5	2.1	0.9	0.7
HRAS	V
VEGFA	V	V	V	V
EGFR	V
CDH1	V	V
ERBB2	V	V
DAPK3	V			V
FGFR3	V		V
MAPK1	V
RAF1	V
TYMP		V
MYC		V	V
TP53		V	V
SRC			V
CDKN1A				V
+ 05215: Prostate cancer	3.2	0.6	0.1	0.8
RELA	V
TCF7L2	V
CDK2	V
HRAS	V
EGFR	V
ERBB2	V	V
PDGFRB	V			V
CREB3L3	V		V	V
TGFA	V
PDPK1	V	V
GSK3B	V
HSP90AA1	V			V
MAPK1	V
RAF1	V
TP53		V	V
IGF1R		V	V
HSP90AB1		V
PIK3CB		V
CTNNB1			V
IKBKG			V
ATF4			V
TCF7				V
CREBBP				V
CDKN1A				V
AKT1				V
+ 05213: Endometrial cancer	4.2	2.6	0.4	1.4
HRAS	V
AXIN1	V			V
AXIN2	V			V
GSK3B	V
ERBB2	V	V
CDH1	V	V
TCF7L2	V
PDPK1	V	V
MLH1	V	V	V
EGFR	V
MAPK1	V
RAF1	V
GADD45A	V
ILK		V
MYC		V	V
PIK3CB		V
TP53		V	V
BAX		V
CTNNB1			V
CTNNA1			V
TCF7				V
AKT1				V
CDKN1A				V
GADD45B				V
+ 05224: Breast cancer	1.4	1.3	0	0.7
EGFR	V
HRAS	V
RAF1	V
MAPK1	V
ERBB2	V	V
SP1	V	V
TCF7L2	V
AXIN1	V			V
AXIN2	V			V
GSK3B	V
NFKB2	V			V
GADD45A	V
NCOA3		V
NCOA1		V
SHC1		V
RPS6KB1		V	V
IGF1R		V	V
PIK3CB		V
MYC		V	V
LRP5		V		V
TP53		V	V
BAX		V
CSNK1A1			V
CTNNB1			V
BRCA1			V
JUN				V
AKT1				V
TCF7				V
CDKN1A				V
HES1				V
GADD45B				V
+ 05222: Small cell lung cancer	1	0.7	0.3	1.2
CDK2	V
ZBTB17	V
FHIT	V
FN1	V	V		V
XIAP	V
RELA	V
GADD45A	V
ITGB1		V	V
MYC		V	V
PIK3CB		V
BAX		V
TP53		V	V
PTK2			V
IKBKG			V
TRAF3			V
SKP2			V
ITGA2				V
AKT1				V
LAMB1				V
BIRC7				V
BCL2L1				V
CDKN1A				V
GADD45B				V
+ 05223: Non-small cell lung cancer	2.8	1.6	0.1	0.2
PDPK1	V	V
HRAS	V
TGFA	V
EGFR	V
ERBB2	V	V
FHIT	V
MAPK1	V
RAF1	V
STAT5A	V	V	V
GADD45A	V
PIK3CB		V
EML4		V
TP53		V	V
BAX		V
PLCG1			V
AKT1				V
CDKN1A				V
GADD45B				V
+ 6.12 Drug resistance: antineoplastic	4.5	4	3	1.9
+ 01521: EGFR tyrosine kinase inhibitor resistance	3.1	1.2	0.7	0.8
ERBB2	V	V
EGFR	V
GSK3B	V
TGFA	V
MAPK1	V
RAF1	V
HRAS	V
MET	V			V
PDGFRB	V			V
FGFR3	V		V
VEGFA	V	V	V	V
AXL	V		V
RPS6KB1		V	V
SHC1		V
PIK3CB		V
IGF1R		V	V
BAX		V
PLCG1			V
SRC			V
EIF4E2			V
ERBB3				V
AKT1				V
BCL2L1				V
+ 01524: Platinum drug resistance	2.6	3.2	1.4	2
XIAP	V
ATP7B	V		V	V
ABCC2	V
GSTT1	V	V	V	V
MGST2	V			V
MLH1	V	V	V
ERBB2	V	V
PDPK1	V	V
MAPK1	V
REV3L	V	V	V	V
TP53		V	V
BIRC5		V	V
BAX		V
GSTM4		V	V
MGST1		V	V
MSH2		V		V
PIK3CB		V
CASP8			V
BRCA1			V
BCL2L1				V
MSH6				V
AKT1				V
CDKN1A				V
+ 01523: Antifolate resistance	2.2	1.6	3.6	0.6
SLC19A1	V			V
ABCC2	V
SLC46A1	V		V
RELA	V
SHMT2	V	V	V	V
ABCC1		V	V
GART		V	V
DHFR		V	V
ABCC3			V
DHFR2			V
IKBKG			V
SHMT1			V
MTHFR			V
+ 01522: Endocrine resistance	1.2	2.1	0.2	0.3
EGFR	V
HRAS	V
RAF1	V
MAPK1	V
GNAS	V
MAPK14	V			V
ERBB2	V	V
SP1	V	V
NCOA3		V
SHC1		V
PIK3CB		V
MAPK9		V
TP53		V	V
RPS6KB1		V	V
IGF1R		V	V
BAX		V
CYP2D6		V
SRC			V
PRKACB			V
ADCY7			V
PTK2			V
ADCY9				V
AKT1				V
CDKN1A				V
JUN				V