Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	DEG (Union)	GSE1739_DEG	GSE1739_Up	GSE1739_Down	GSE5972_DEG	GSE5972_Up	GSE5972_Down	DisGenet SARS	Nature 24H	Nature 24H 10%
	1202/2201	816/1464	313/534	504/930	451/851	73/145	379/706	82/109	69/117	65/117
+ 1. Metabolism	8.1	6.8	6.1	5.4	6.7	2.9	6.4	3	4.6	6.2
+ 1.0 Global and overview maps	4.2	3	2.4	2.4	3.9	0.9	4.1	4.2	1.7	2.5
+ 01100: Metabolic pathways	3.2	2.7	2.8	1.4	2	0.7	2.1	0.4	1.4	3.1
ARG1	V	V	V
SDHD	V	V		V
FKTN	V	V		V
PDXK	V	V	V
GMPPB	V	V	V
TGDS	V	V		V
BCKDHB	V	V		V
HSD17B4	V				V		V
SCP2	V	V		V
SCD	V	V	V						V
ALDOA	V				V		V
GLB1	V				V		V
RRM2B	V				V		V
RRM2	V	V	V						V	V
GSTP1	V				V		V
GSTO1	V	V	V
ANPEP	V	V	V					V
GPX3	V				V		V
GPX4	V				V		V
GLUL	V	V	V		V		V
MTR	V	V		V
ALDH3A2	V	V		V
HK1	V				V		V		V	V
PIK3CB	V	V	V
PIP5K1B	V				V		V
INPP4A	V	V		V
MTMR6	V				V		V
ITPK1	V	V	V
PIP4K2A	V				V		V
PLCG1	V	V		V
INPP5A	V	V	V
INPP5K	V				V		V
IMPA1	V	V		V
IMPA2	V	V	V		V		V
ITPKB	V	V		V	V		V
ACADM	V	V		V
GADL1	V				V	V
LDHB	V	V		V
DCK	V	V		V
NT5E	V	V		V
TK1	V	V	V						V	V
CDA	V	V	V
ENPP4	V	V		V
PDE3B	V	V		V
PDE4B	V	V		V
ADCY7	V				V		V
ENTPD4	V				V		V
GMPR	V	V	V
PDE6H	V	V	V
IMPDH1	V	V	V
ADPRM	V	V		V
TST	V	V	V
CA2	V				V	V
CA4	V	V	V
MDH1	V	V		V
MDH2	V				V		V
ADH5	V	V		V
ESD	V				V		V
OXCT1	V	V		V
GLA	V	V	V
DPM2	V				V		V
PFKFB3	V	V	V
B3GNT2	V	V		V
ALG5	V				V		V
GPI	V				V		V
B3GALNT1	V	V		V
B4GALT5	V	V	V
MGAM	V	V	V
BLVRA	V	V		V
BLVRB	V	V	V
COX15	V				V		V
B4GALT1	V				V		V
GALE	V	V		V
HEXA	V				V	V
IDS	V				V		V
LIAS	V				V	V
LIPT1	V	V		V
GCLC	V	V		V
CHIT1	V	V	V
BPGM	V				V	V
CYP2C9	V	V	V
CYP2C18	V	V	V
PRDX6	V				V		V
AK5	V	V		V
ALPL	V	V	V
ACP1	V	V		V
AKR1B1	V				V		V
PFKM	V				V	V
HMGCS1	V	V		V
DGKA	V	V		V
DGKG	V	V		V
DGKD	V				V		V
PLPP1	V	V		V
HSD11B2	V				V	V
ALDH6A1	V	V		V
CYP7A1	V	V		V
PGD	V				V		V
UGDH	V	V		V
AKR1A1	V				V		V
KL	V	V	V
FPGT	V	V		V
ALDH5A1	V	V		V
MAT2B	V	V		V
MRI1	V				V	V
AMD1	V				V		V
DNMT1	V	V		V
ADH1B	V				V		V
ADH6	V	V	V
TH	V	V		V
HAAO	V	V	V
ALDH18A1	V	V		V
FTCD	V	V	V
IVD	V	V		V
MCCC2	V	V		V
ACSL1	V	V	V
ACSL6	V				V		V
CYP27A1	V	V	V
AMACR	V	V		V
AKR1C3	V	V		V
CYP19A1	V				V	V
TKTL1	V	V		V
GAPDH	V	V	V		V		V	V
TYMS	V	V	V		V	V
BAAT	V				V		V
PISD	V				V		V
CHKB	V	V		V
ETNK2	V				V	V
PAFAH1B1	V	V		V
PAFAH2	V	V		V
PLA2G7	V	V		V
KDSR	V	V		V
CERS2	V				V		V
ASAH1	V				V		V
ALOX12	V	V	V
ALOX12B	V	V	V
CYP4F3	V	V	V
ALOX5	V	V	V		V		V
PTGES	V	V	V
NNT	V	V		V
PTDSS1	V				V		V
ALG8	V				V		V
MAN1C1	V	V		V
ST6GAL1	V	V		V
POC1B-GALNT4	V	V		V
GALNT4	V	V		V
GALNT8	V	V	V
PIGP	V	V		V
PIGH	V				V		V
B4GALT6	V	V		V
ST3GAL5	V	V		V
B3GALT4	V	V	V
ST8SIA5	V	V	V
ST6GALNAC4	V				V		V
CPOX	V	V		V
ACSM3	V	V		V
ENO1	V				V		V
LTA4H	V	V	V
GCK	V	V	V
ADPGK	V				V		V
TALDO1	V	V	V		V		V
DCTD	V	V		V
PRPS1	V	V		V
GLUD2	V	V		V
TPI1	V				V		V
GALNS	V	V	V
GNS	V	V		V	V		V
IDH3A	V	V		V
SUCLA2	V	V		V
ALDH1A1	V	V		V						V
DHRS9	V	V	V
DHRS3	V	V		V
ENOPH1	V	V		V
NAMPT	V	V	V		V		V
PIGL	V	V		V
GCNT3	V	V	V							V
GYG1	V	V	V						V	V
AGL	V	V		V	V		V
PYGL	V	V	V
VKORC1	V				V		V
AMPD2	V				V		V
MOCS2	V	V		V
G6PD	V				V		V
ETHE1	V				V		V
AANAT	V	V	V
CS	V				V		V
COX4I1	V				V		V
COX6A1	V	V	V		V		V
COX7C	V				V		V
TCIRG1	V	V	V
ATP5F1C	V	V		V
ATP5PB	V				V		V
ATP5MC1	V				V		V
ATP5MC2	V				V		V
ATP6V0B	V				V		V
NDUFA1	V				V		V
NDUFA5	V	V		V
NDUFA7	V				V		V
NDUFC2	V				V		V
PI4KB								V
GOT1								V
SDS								V
GPT								V
TPO								V
HKDC1									V	V
PLA2G2A									V	V
IDI2									V
COQ6									V	V
ALDH1A2									V	V
ATP6V0A4									V	V
ATP5PF									V	V
CBR4										V
ALDH2										V
CDS1										V
OAT										V
ISYNA1										V
NDUFA4										V
+ 01200: Carbon metabolism	3	1.3	0.5	1.6	3.4	0.5	3.6	2.8	1.4	1.4
ALDOA	V				V		V
TKTL1	V	V		V
GAPDH	V	V	V		V		V	V
PFKM	V				V	V
GCK	V	V	V
HK1	V				V		V		V	V
ADPGK	V				V		V
GPI	V				V		V
G6PD	V				V		V
PGD	V				V		V
TPI1	V				V		V
TALDO1	V	V	V		V		V
ENO1	V				V		V
CS	V				V		V
MDH1	V	V		V
MDH2	V				V		V
SDHD	V	V		V
SUCLA2	V	V		V
IDH3A	V	V		V
PRPS1	V	V		V
ADH5	V	V		V
ESD	V				V		V
ALDH6A1	V	V		V
GLUD2	V	V		V
SDS								V
GOT1								V
GPT								V
HKDC1									V	V
+ 01210: 2-Oxocarboxylic acid metabolism	0.5	0.3	0	0.5	0.6	0	0.7	2.8	0	0
CS	V				V		V
IDH3A	V	V		V
GOT1								V
GPT								V
+ 01212: Fatty acid metabolism	0.5	0.5	0.7	0.3	0.4	0	0.5	0	1	1
SCD	V	V	V						V
SCP2	V	V		V
HSD17B4	V				V		V
ACSL1	V	V	V
ACSL6	V				V		V
ACADM	V	V		V
CBR4										V
+ 01230: Biosynthesis of amino acids	2.3	1.9	1.4	1.4	2.4	0.8	2.3	3.3	0	0
TPI1	V				V		V
GAPDH	V	V	V		V		V	V
ENO1	V				V		V
ALDOA	V				V		V
PFKM	V				V	V
TKTL1	V	V		V
PRPS1	V	V		V
MTR	V	V		V
CS	V				V		V
IDH3A	V	V		V
ARG1	V	V	V
ALDH18A1	V	V		V
GLUL	V	V	V		V		V
TALDO1	V	V	V		V		V
MAT2B	V	V		V
SDS								V
GOT1								V
GPT								V
+ 1.1 Carbohydrate metabolism	5.6	3.7	3	3.2	5.3	1.7	5.2	0.5	3.2	4.4
+ 00010: Glycolysis / Gluconeogenesis	3	0.8	1.1	0.5	3.8	1.7	3.4	1	1.9	2.7
ALDOA	V				V		V
ALDH3A2	V	V		V
AKR1A1	V				V		V
ADH1B	V				V		V
ADH5	V	V		V
ADH6	V	V	V
LDHB	V	V		V
ENO1	V				V		V
BPGM	V				V	V
GAPDH	V	V	V		V		V	V
TPI1	V				V		V
PFKM	V				V	V
GPI	V				V		V
HK1	V				V		V		V	V
GCK	V	V	V
ADPGK	V				V		V
HKDC1									V	V
ALDH2										V
+ 00020: Citrate cycle (TCA cycle)	1.6	1.3	0	1.9	0.9	0	1	0	0	0
SUCLA2	V	V		V
IDH3A	V	V		V
CS	V				V		V
MDH1	V	V		V
MDH2	V				V		V
SDHD	V	V		V
+ 00030: Pentose phosphate pathway	2.4	0.8	0.6	0.8	3.1	1.3	2.9	0	0	0
GPI	V				V		V
PRPS1	V	V		V
TKTL1	V	V		V
ALDOA	V				V		V
PFKM	V				V	V
PGD	V				V		V
G6PD	V				V		V
TALDO1	V	V	V		V		V
+ 00040: Pentose and glucuronate interconversions	0.6	0.3	0.5	0.2	0.8	0	0.9	0	0	0
KL	V	V	V
AKR1B1	V				V		V
UGDH	V	V		V
AKR1A1	V				V		V
+ 00051: Fructose and mannose metabolism	2.2	0.7	1.2	0.2	2.5	1.2	2.2	0	2.4	2.4
AKR1B1	V				V		V
HK1	V				V		V		V	V
PFKFB3	V	V	V
FPGT	V	V		V
GMPPB	V	V	V
PFKM	V				V	V
TPI1	V				V		V
ALDOA	V				V		V
HKDC1									V	V
+ 00052: Galactose metabolism	2.7	1.3	1.9	0.3	2.5	1.3	2.2	0	2.4	2.4
GLA	V	V	V
PFKM	V				V	V
MGAM	V	V	V
AKR1B1	V				V		V
GCK	V	V	V
HK1	V				V		V		V	V
GLB1	V				V		V
B4GALT1	V				V		V
GALE	V	V		V
HKDC1									V	V
+ 00053: Ascorbate and aldarate metabolism	0.2	0.5	0	0.9	0	0	0	0	0	1.4
UGDH	V	V		V
ALDH3A2	V	V		V
ALDH2										V
+ 00500: Starch and sucrose metabolism	1.6	1.5	2.4	0.2	1.2	0	1.5	0	3.2	3.2
HK1	V				V		V		V	V
MGAM	V	V	V
GYG1	V	V	V						V	V
GCK	V	V	V
GPI	V				V		V
AGL	V	V		V	V		V
PYGL	V	V	V
HKDC1									V	V
+ 00520: Amino sugar and nucleotide sugar metabolism	2	1.4	1.4	0.8	1.4	1	1.1	0	2.1	2.1
HEXA	V				V	V
CHIT1	V	V	V
HK1	V				V		V		V	V
CYB5R3	V				V		V
GALE	V	V		V
UGDH	V	V		V
GMPPB	V	V	V
FPGT	V	V		V
GPI	V				V		V
GCK	V	V	V
HKDC1									V	V
+ 00620: Pyruvate metabolism	0.4	0.6	0	1.1	0.2	0	0.3	0	0	1.2
MDH1	V	V		V
MDH2	V				V		V
LDHB	V	V		V
ALDH3A2	V	V		V
ALDH2										V
+ 00630: Glyoxylate and dicarboxylate metabolism	0.8	0.4	0.6	0.3	1.5	0	1.7	0	0	0
CS	V				V		V
MDH1	V	V		V
MDH2	V				V		V
GLUL	V	V	V		V		V
+ 00640: Propanoate metabolism	0.6	1.1	0	1.8	0	0	0	0	0	0
ALDH6A1	V	V		V
LDHB	V	V		V
SUCLA2	V	V		V
BCKDHB	V	V		V
+ 00650: Butanoate metabolism	0.8	1.4	0	2	0	0	0	0	0	0
OXCT1	V	V		V
HMGCS1	V	V		V
ALDH5A1	V	V		V
ACSM3	V	V		V
+ 00562: Inositol phosphate metabolism	2.1	1.6	1.4	1.1	2	0	2.4	0.9	0	0.9
PIP4K2A	V				V		V
INPP5A	V	V	V
INPP5K	V				V		V
ITPKB	V	V		V	V		V
ITPK1	V	V	V
INPP4A	V	V		V
IMPA1	V	V		V
IMPA2	V	V	V		V		V
PIP5K1B	V				V		V
MTMR6	V				V		V
PLCG1	V	V		V
PIK3CB	V	V	V
ALDH6A1	V	V		V
TPI1	V				V		V
PI4KB								V
ISYNA1										V
+ 1.2 Energy metabolism	1.8	1.2	1.8	0.4	2.5	0.9	2.5	0	0.8	1.1
+ 00190: Oxidative phosphorylation	0.6	0	0.1	0.1	2.1	0	2.6	0	1.3	2
COX4I1	V				V		V
NDUFC2	V				V		V
NDUFA7	V				V		V
NDUFA5	V	V		V
NDUFA1	V				V		V
COX15	V				V		V
COX7C	V				V		V
COX6A1	V	V	V		V		V
TCIRG1	V	V	V
ATP5F1C	V	V		V
ATP5PB	V				V		V
ATP5MC1	V				V		V
ATP5MC2	V				V		V
ATP6V0B	V				V		V
SDHD	V	V		V
ATP6V0A4									V	V
ATP5PF									V	V
NDUFA4										V
+ 00910: Nitrogen metabolism	1.6	1.5	1.8	0.6	1.4	1.6	0.7	0	0	0
CA2	V				V	V
CA4	V	V	V
GLUL	V	V	V		V		V
GLUD2	V	V		V
+ 00920: Sulfur metabolism	1	0.6	1.2	0	0.9	0	1	0	0	0
TST	V	V	V
ETHE1	V				V		V
+ 1.3 Lipid metabolism	3.2	3	2.1	2.9	1.9	0.6	2.1	0.3	1.9	3
+ 00061: Fatty acid biosynthesis	0.5	0.3	0.8	0	0.6	0	0.7	0	0	1.6
ACSL1	V	V	V
ACSL6	V				V		V
CBR4										V
+ 00062: Fatty acid elongation	0	0	0	0	0	0	0	0	0	0
+ 00071: Fatty acid degradation	1.5	1.6	0.9	1.4	0.5	0	0.7	0	0	1.2
ACADM	V	V		V
ECI2	V	V		V
ADH1B	V				V		V
ADH5	V	V		V
ADH6	V	V	V
ACSL1	V	V	V
ACSL6	V				V		V
ALDH3A2	V	V		V
ALDH2										V
+ 00072: Synthesis and degradation of ketone bodies	1	1.4	0	1.7	0	0	0	0	0	0
HMGCS1	V	V		V
OXCT1	V	V		V
+ 00100: Steroid biosynthesis	0.4	0.3	0	0.5	0.6	0	0.7	0	0	0
LIPA	V				V		V
SOAT1	V	V		V
+ 00120: Primary bile acid biosynthesis	2.6	2.1	0.9	2	1.4	0	1.5	0	0	0
CYP7A1	V	V		V
CYP27A1	V	V	V
AMACR	V	V		V
HSD17B4	V				V		V
SCP2	V	V		V
BAAT	V				V		V
+ 00140: Steroid hormone biosynthesis	0.1	0.1	0	0.3	0.3	1.8	0	1.1	0	0
AKR1C3	V	V		V
HSD11B2	V				V	V
CYP19A1	V				V	V
CYP7A1	V	V		V
SULT1E1								V
+ 00561: Glycerolipid metabolism	0.8	0.7	0.2	1	0.7	0	0.9	0	0	1
PLPP1	V	V		V
AKR1B1	V				V		V
ALDH3A2	V	V		V
AKR1A1	V				V		V
GLA	V	V	V
DGKA	V	V		V
DGKG	V	V		V
DGKD	V				V		V
ALDH2										V
+ 00564: Glycerophospholipid metabolism	0.6	0.5	0.1	1	0.5	0.6	0.4	0	0.8	1.6
PTDSS1	V				V		V
LPCAT3	V	V		V
CHKB	V	V		V
ETNK2	V				V	V
DGKA	V	V		V
DGKG	V	V		V
DGKD	V				V		V
PLPP1	V	V		V
ADPRM	V	V		V
PISD	V				V		V
MBOAT7	V	V	V
PLA2G2A									V	V
CDS1										V
+ 00565: Ether lipid metabolism	0.8	1.1	0	1.8	0.2	0	0.2	0	1.2	1.2
PLPP1	V	V		V
PAFAH1B1	V	V		V
PAFAH2	V	V		V
PLA2G7	V	V		V
TMEM86B	V				V		V
ENPP2	V	V		V
PLA2G2A									V	V
+ 00600: Sphingolipid metabolism	2.1	1.5	0.9	1.3	1.4	0	1.7	0	0	1.2
SGPP1	V	V		V
ASAH1	V				V		V
CERS2	V				V		V
CERK	V				V		V
PLPP1	V	V		V
KDSR	V	V		V
GLA	V	V	V
GLB1	V				V		V
ARSA	V	V	V
B4GALT6	V	V		V
NEU1										V
+ 00590: Arachidonic acid metabolism	1.1	1.7	3.2	0.1	0.3	0	0.4	0	1	1
CYP2C9	V	V	V
ALOX12B	V	V	V
GPX3	V				V		V
CYP4F3	V	V	V
ALOX12	V	V	V
ALOX5	V	V	V		V		V
LTA4H	V	V	V
PTGES	V	V	V
AKR1C3	V	V		V
PLA2G2A									V	V
+ 00591: Linoleic acid metabolism	0	0.1	0.6	0	0	0	0	0	1.4	1.4
CYP2C9	V	V	V
PLA2G2A									V	V
+ 00592: alpha-Linolenic acid metabolism	0	0	0	0	0	0	0	0	1.5	1.5
PLA2G2A									V	V
+ 01040: Biosynthesis of unsaturated fatty acids	0.9	0.5	0.6	0.3	1	0	1.1	0	1.4	0
SCP2	V	V		V
HSD17B4	V				V		V
BAAT	V				V		V
SCD	V	V	V						V
+ 1.4 Nucleotide metabolism	1.5	1.8	1.8	1.2	0.7	0.7	0.6	0	1.8	1.8
+ 00230: Purine metabolism	0.8	1.1	0.7	1.1	0.2	0	0.4	0	0.6	0.6
RRM2B	V				V		V
RRM2	V	V	V						V	V
PRPS1	V	V		V
PDE3B	V	V		V
ADCY7	V				V		V
AK5	V	V		V
AMPD2	V				V		V
NT5E	V	V		V
GMPR	V	V	V
IMPDH1	V	V	V
ENTPD4	V				V		V
PDE6H	V	V	V
ADPRM	V	V		V
ENPP4	V	V		V
DCK	V	V		V
PDE4B	V	V		V
+ 00240: Pyrimidine metabolism	1.3	1.5	1.8	0.6	0.7	0.9	0.5	0	2	2
RRM2B	V				V		V
RRM2	V	V	V						V	V
ENTPD4	V				V		V
NT5E	V	V		V
CDA	V	V	V
DCK	V	V		V
DCTD	V	V		V
TK1	V	V	V						V	V
TYMS	V	V	V		V	V
+ 1.5 Amino acid metabolism	1.7	2.4	1.4	2.4	0.7	0.6	0.6	5.1	0	1.9
+ 00250: Alanine, aspartate and glutamate metabolism	0.3	0.6	0.5	0.6	0.2	0	0.3	2.4	0	0
ALDH5A1	V	V		V
GLUD2	V	V		V
GLUL	V	V	V		V		V
GOT1								V
GPT								V
+ 00260: Glycine, serine and threonine metabolism	0	0	0	0	0.2	1.1	0	1.3	0	0
BPGM	V				V	V
SDS								V
+ 00270: Cysteine and methionine metabolism	2.3	2.2	0.3	2.6	0.9	1	0.6	2.2	0	0
MRI1	V				V	V
AMD1	V				V		V
MTR	V	V		V
MAT2B	V	V		V
DNMT1	V	V		V
ENOPH1	V	V		V
TST	V	V	V
LDHB	V	V		V
MDH1	V	V		V
MDH2	V				V		V
GCLC	V	V		V
SDS								V
GOT1								V
+ 00280: Valine, leucine and isoleucine degradation	1.4	2.2	0	3.1	0	0	0	0	0	1.1
BCKDHB	V	V		V
HMGCS1	V	V		V
OXCT1	V	V		V
MCCC2	V	V		V
IVD	V	V		V
ALDH3A2	V	V		V
ALDH6A1	V	V		V
ACADM	V	V		V
ALDH2										V
+ 00290: Valine, leucine and isoleucine biosynthesis	0	0	0	0	0	0	0	2.3	0	0
SDS								V
+ 00310: Lysine degradation	0.1	0.2	0.2	0.3	0.1	0	0.1	0	0	1
EHMT2	V	V		V
SETD1A	V				V		V
PLOD1	V	V	V
ALDH3A2	V	V		V
ALDH2										V
+ 00220: Arginine biosynthesis	0.8	1.3	1.6	0.5	0.5	0	0.6	2.7	0	0
GLUL	V	V	V		V		V
ARG1	V	V	V
GLUD2	V	V		V
GOT1								V
GPT								V
+ 00330: Arginine and proline metabolism	0.2	0.3	0.3	0.4	0.1	0	0.2	1.2	0	2.1
ARG1	V	V	V
ALDH3A2	V	V		V
AMD1	V				V		V
ALDH18A1	V	V		V
GOT1								V
ALDH2										V
OAT										V
+ 00340: Histidine metabolism	0.3	0.7	0.7	0.4	0	0	0	0	0	1.5
FTCD	V	V	V
ALDH3A2	V	V		V
ALDH2										V
+ 00350: Tyrosine metabolism	0.6	0.7	0.5	0.7	0.3	0	0.3	2.4	0	0
ADH1B	V				V		V
ADH5	V	V		V
ADH6	V	V	V
TH	V	V		V
TPO								V
GOT1								V
+ 00360: Phenylalanine metabolism	0	0	0	0	0	0	0	1.7	0	0
GOT1								V
+ 00380: Tryptophan metabolism	0.2	0.5	1	0.2	0	0	0	0	0	1.2
AANAT	V	V	V
HAAO	V	V	V
ALDH3A2	V	V		V
ALDH2										V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	0	0	0	0	2.2	0	0
GOT1								V
+ 1.6 Metabolism of other amino acids	1.4	0.8	0.5	1	1.6	1.1	1.3	0.4	0.4	0.9
+ 00410: beta-Alanine metabolism	0.4	0.4	0	0.7	0.3	1.2	0	0	0	1.3
ALDH6A1	V	V		V
GADL1	V				V	V
ALDH3A2	V	V		V
ALDH2										V
+ 00430: Taurine and hypotaurine metabolism	0.9	0	0	0	1.7	1.8	1	0	0	0
GADL1	V				V	V
BAAT	V				V		V
+ 00440: Phosphonate and phosphinate metabolism	0	0	0	0	0	0	0	0	0	0
+ 00450: Selenocompound metabolism	0.2	0.3	0	0.6	0	0	0	0	0	0
MTR	V	V		V
+ 00471: D-Glutamine and D-glutamate metabolism	0.7	1	0	1.2	0	0	0	0	0	0
GLUD2	V	V		V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0	0	0	0	0	0
+ 00480: Glutathione metabolism	1.6	0.5	1.3	0.1	2.1	0	2.4	1.1	1.1	1.1
ANPEP	V	V	V					V
GPX3	V				V		V
GPX4	V				V		V
G6PD	V				V		V
GCLC	V	V		V
GSTP1	V				V		V
GSTO1	V	V	V
PGD	V				V		V
RRM2B	V				V		V
RRM2	V	V	V						V	V
+ 1.7 Glycan biosynthesis and metabolism	3.4	2.4	1.5	2.4	3.2	1.7	2.7	0	0.5	1.2
+ 00510: N-Glycan biosynthesis	0.7	0.1	0	0.4	1.4	0	1.6	0	0	0
DPM2	V				V		V
B4GALT1	V				V		V
ST6GAL1	V	V		V
MAN1C1	V	V		V
ALG5	V				V		V
ALG8	V				V		V
+ 00512: Mucin type O-glycan biosynthesis	1.1	1.8	2	0.8	0	0	0	0	0	1.4
GCNT3	V	V	V							V
B4GALT5	V	V	V
POC1B-GALNT4	V	V		V
GALNT4	V	V		V
GALNT8	V	V	V
+ 00515: Mannose type O-glycan biosynthesis	0.3	0.2	0	0.4	0.5	0	0.6	0	0	0
B4GALT1	V				V		V
FKTN	V	V		V
+ 00514: Other types of O-glycan biosynthesis	0.7	0.7	0	1.1	0.5	0	0.6	0	0	0
ST6GAL1	V	V		V
B4GALT1	V				V		V
OGT	V	V		V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.1	0.3	0	0.5	0	0	0	0	0	0
UST	V	V		V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.3	0.7	0	1.1	0	0	0	0	0	0
HS3ST1	V	V		V
HS2ST1	V	V		V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0.7	0.4	0	0.7	0.7	0	0.8	0	0	0
B3GNT2	V	V		V
B4GALT1	V				V		V
+ 00531: Glycosaminoglycan degradation	1.9	0.8	0.8	0.5	2.6	1.5	2.2	0	0	0
GNS	V	V		V	V		V
IDS	V				V		V
GALNS	V	V	V
GLB1	V				V		V
HEXA	V				V	V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1.1	0.6	0	1	1.1	0	1.3	0	0	0
DPM2	V				V		V
PIGP	V	V		V
PIGH	V				V		V
PIGL	V	V		V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0.5	0.5	0	0.9	0.4	0	0.5	0	0	0
B3GNT2	V	V		V
B4GALT1	V				V		V
B3GALNT1	V	V		V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	1.2	1	0.9	0.6	0.7	1.6	0	0	0	0
HEXA	V				V	V
GLA	V	V	V
B3GALNT1	V	V		V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	2.8	1.6	1.9	0.6	2.2	1.6	1.6	0	0	0
GLB1	V				V		V
HEXA	V				V	V
ST8SIA5	V	V	V
B3GALT4	V	V	V
ST6GALNAC4	V				V		V
ST3GAL5	V	V		V
+ 00511: Other glycan degradation	0.5	0	0	0	1.3	1.5	0.7	0	1.6	2.8
GLB1	V				V		V
HEXA	V				V	V
AGA									V	V
NEU1										V
+ 1.8 Metabolism of cofactors and vitamins	3.3	3.6	3.2	2.4	1.4	1.5	0.8	0	0.8	1.1
+ 00730: Thiamine metabolism	1.2	1.6	0.9	1.4	0	0	0	0	0	0
AK5	V	V		V
ALPL	V	V	V
ACP1	V	V		V
+ 00740: Riboflavin metabolism	1.2	1.6	1.3	1	0	0	0	0	0	0
BLVRB	V	V	V
ACP1	V	V		V
+ 00750: Vitamin B6 metabolism	0.6	0.9	1.4	0	0	0	0	0	0	0
PDXK	V	V	V
+ 00760: Nicotinate and nicotinamide metabolism	0.4	0.8	0.6	0.8	0.3	0	0.4	0	0	0
NAMPT	V	V	V		V		V
NNT	V	V		V
NT5E	V	V		V
+ 00770: Pantothenate and CoA biosynthesis	1.4	1.4	1.7	0.5	0.6	1.5	0	0	0	0
VNN2	V	V	V
VNN1	V	V	V
GADL1	V				V	V
AASDHPPT	V	V		V
+ 00780: Biotin metabolism	0	0	0	0	0	0	0	0	0	0
+ 00785: Lipoic acid metabolism	2.1	1.3	0	1.5	1.5	2.3	0	0	0	0
LIAS	V				V	V
LIPT1	V	V		V
+ 00790: Folate biosynthesis	1.9	2.1	1.4	1.6	0.4	0	0.5	0	0	0
GGH	V	V	V
ALPL	V	V	V
MOCS2	V	V		V
TH	V	V		V
AKR1B1	V				V		V
AKR1C3	V	V		V
+ 00670: One carbon pool by folate	0.8	1.3	1.6	0.5	0.5	1.5	0	0	0	0
FTCD	V	V	V
TYMS	V	V	V		V	V
MTR	V	V		V
+ 00830: Retinol metabolism	0.7	1.2	1.6	0.5	0.1	0	0.1	0	1	1.9
ADH1B	V				V		V
ADH5	V	V		V
ADH6	V	V	V
ALDH1A1	V	V		V						V
DHRS9	V	V	V
DHRS3	V	V		V
CYP2C9	V	V	V
CYP2C18	V	V	V
ALDH1A2									V	V
+ 00860: Porphyrin and chlorophyll metabolism	0.6	0.5	0.4	0.5	0.6	0	0.7	0	0	0
CPOX	V	V		V
BLVRA	V	V		V
BLVRB	V	V	V
FXN	V				V		V
COX15	V				V		V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0.4	0	0	0	0.9	0	1	0	1.9	1.9
VKORC1	V				V		V
COQ6									V	V
+ 1.9 Metabolism of terpenoids and polyketides	0.3	0.2	0	0.4	0.5	0	0.6	0	1.5	0
+ 00900: Terpenoid backbone biosynthesis	0.3	0.2	0	0.4	0.5	0	0.6	0	1.5	0
HMGCS1	V	V		V
FNTA	V				V		V
IDI2									V
+ 1.10 Biosynthesis of other secondary metabolites	1.2	0.7	1.1	0	0.9	0	1	0	2.5	2.5
+ 00232: Caffeine metabolism	0	0	0	0	0	0	0	0	0	0
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	1.6	1	1.5	0	1.3	0	1.4	0	3.6	3.6
HK1	V				V		V		V	V
GCK	V	V	V
HKDC1									V	V
+ 1.11 Xenobiotics biodegradation and metabolism	0.5	0.6	2.4	0	0.5	0.5	0.5	0	1	1
+ 00980: Metabolism of xenobiotics by cytochrome P450	0.2	0.2	0.9	0	0.2	0	0.3	0	0	0
GSTP1	V				V		V
GSTO1	V	V	V
ADH1B	V				V		V
ADH5	V	V		V
ADH6	V	V	V
CYP2C9	V	V	V
+ 00982: Drug metabolism - cytochrome P450	0.4	0.3	1	0	0.5	0.8	0.3	0	0	0
FMO5	V				V	V
CYP2C9	V	V	V
GSTP1	V				V		V
GSTO1	V	V	V
ADH1B	V				V		V
ADH5	V	V		V
ADH6	V	V	V
+ 00983: Drug metabolism - other enzymes	0.4	0.6	2.3	0	0.2	0	0.3	0	1.7	1.7
TK1	V	V	V						V	V
IMPDH1	V	V	V
CDA	V	V	V
RRM2B	V				V		V
RRM2	V	V	V						V	V
MPO	V	V	V
GSTP1	V				V		V
GSTO1	V	V	V
+ 2. Genetic Information Processing	12.5	8.7	1	11.1	10.4	1.4	11.1	1.5	1.4	1.7
+ 2.1 Transcription	6.1	4.5	0	6.3	4.4	0.6	4.7	0	0.8	0.8
+ 03020: RNA polymerase	2.3	1.3	0	1.9	2.5	0	2.8	0	0	1.4
POLR2B	V	V		V	V		V
POLR2A	V				V		V
POLR2C	V				V		V
POLR2F	V				V		V			V
POLR2G	V				V		V
POLR2J2	V	V		V
POLR2J3	V	V		V
POLR2J	V	V		V
+ 03022: Basal transcription factors	2.2	1.5	0	2.3	1.5	0	1.7	0	0	0
TBP	V	V		V
TAF4	V	V		V
TAF7L	V	V		V
TAF7	V				V		V
TAF10	V				V		V
TAF11	V	V		V
GTF2B	V				V		V
GTF2E1	V	V		V
ERCC3	V	V		V
TAF12	V				V		V
+ 03040: Spliceosome	6.1	5	0	6.6	3.7	1.1	3.6	0	1.3	0
DHX38	V				V		V
CDC40	V	V		V
DHX8	V	V		V
DHX15	V	V		V
SNRPB	V				V		V
DDX5	V				V		V
TCERG1	V	V		V
SNRPB2	V	V		V
SF3B4	V				V		V
SF3B2	V				V		V
U2AF2	V	V		V
SMNDC1	V	V		V
NCBP2	V	V		V
NCBP1	V	V		V
RBMX	V				V		V
HNRNPA1	V	V		V
HNRNPC	V				V		V		V
HNRNPK	V				V		V
PCBP1	V				V		V
SRSF10	V	V		V
TRA2A	V	V		V
SRSF1	V	V		V
SRSF2	V	V		V
SRSF3	V	V		V
SRSF5	V	V		V	V	V
SRSF7	V	V		V
PRPF19	V	V		V
HSPA1A	V				V		V
HSPA1B	V				V		V
HSPA8	V	V		V	V		V
WBP11	V	V		V
LSM8	V	V		V
PPIH	V	V		V					V
PRPF4	V	V		V
PRPF3	V	V		V
SNRNP200	V	V		V
SNRNP40	V				V	V
EIF4A3	V				V		V
MAGOH	V	V		V
MAGOHB	V	V		V
PRPF18	V	V		V	V		V
+ 2.2 Translation	8	4.6	0.7	5.5	7	0	7.9	1.2	1.3	1.3
+ 03010: Ribosome	5.6	0	0	0.1	8.9	0	9.6	0	0	0
RPL13	V				V		V
RPS23	V				V		V
RPS6	V				V		V
RPS19	V				V		V
RPS24	V				V		V
RPS27	V				V		V
RPS12	V				V		V
RPS26	V				V		V
RPS4Y1	V	V	V		V		V
RPS3A	V				V		V
RPL9	V				V		V
RPL13A	V				V		V
RPL10A	V				V		V
RPL8	V				V		V
RPL23	V				V		V
RPL27A	V				V		V
RPL5	V	V		V
MRPL18	V				V		V
RPL18	V				V		V
RPL21	V				V		V
RSL24D1	V	V		V
RPL24	V				V		V
RPL30	V				V		V
UBA52	V				V		V
RPL31	V				V		V
RPL32	V				V		V
RPL37	V				V		V
RPL37A	V				V		V
RPL6	V				V		V
RPL22	V				V		V
RPL38	V				V		V
RPL4	V				V		V
RPL10	V				V		V
RPL14	V	V		V
RPLP1	V				V		V
RPLP2	V				V		V
RPS5	V				V		V
RPS16	V				V		V
RPS3	V				V		V
+ 00970: Aminoacyl-tRNA biosynthesis	0.3	0.8	0	1.4	0.2	0	0.2	2.2	0	0
FARS2	V	V		V
RARS	V	V		V
DARS	V	V		V	V		V
KARS	V	V		V
SARS2								V
SARS								V
+ 03013: RNA transport	6	4.7	0.8	5.2	3.1	0	3.7	0.5	1.1	0.5
RAN	V				V		V
XPO1	V	V		V
NCBP2	V	V		V
NCBP1	V	V		V
GEMIN2	V	V		V
SMN1	V	V		V
SMN2	V	V		V
KPNB1	V	V		V
MAGOH	V	V		V
MAGOHB	V	V		V
EIF4A3	V				V		V
RNPS1	V				V		V
SRRM1	V				V		V
NXF1	V				V		V
NXF3	V				V		V
NXF2	V	V	V
NXF2B	V	V	V
PNN	V	V		V
NUP62	V	V		V
NUP153	V	V		V
NUP54	V	V		V
NUP214	V	V	V
NUP88	V	V		V
UBE2I	V				V		V	V
NUP42	V				V		V
EEF1A1	V				V		V
NMD3	V	V		V
EIF1	V				V		V
EIF1AX	V	V		V
EIF1AY	V	V	V
EIF3CL	V				V		V
EIF3A	V	V		V
EIF3J	V	V		V
RPP38	V	V		V
PABPC1	V				V		V
PABPC4	V				V		V
EIF2S3	V	V		V
EIF2S2	V				V		V
EIF4A2	V	V		V
UPF3B	V	V		V
EIF4B	V	V		V
TACC3	V	V	V
EIF2B1	V				V		V
EIF2B2	V				V		V
FMR1	V	V		V
FXR1	V	V		V
RANBP2									V
PRMT5									V	V
+ 03015: mRNA surveillance pathway	4.1	3	0.4	3.6	2.8	0	3.2	0	0	0
MAGOH	V	V		V
MAGOHB	V	V		V
EIF4A3	V				V		V
RNPS1	V				V		V
SRRM1	V				V		V
NXF1	V				V		V
NXF3	V				V		V
NXF2	V	V	V
NXF2B	V	V	V
PNN	V	V		V
NCBP1	V	V		V
UPF3B	V	V		V
RNGTT	V	V		V
RNMT	V	V		V
NUDT21	V	V		V
PCF11	V	V		V
CSTF3	V	V		V
NCBP2	V	V		V
PABPC1	V				V		V
PABPC4	V				V		V
PPP2R1A	V				V		V
PPP2R5C	V	V		V	V		V
PPP2R5D	V				V		V
PPP2R5E	V	V		V
+ 03008: Ribosome biogenesis in eukaryotes	1.9	1.8	0.5	2.1	0.7	0	1	0	1.7	2.5
RAN	V				V		V
XPO1	V	V		V
NMD3	V	V		V
DKC1	V	V		V
RPP38	V	V		V
GNL3	V	V		V
NVL	V	V		V						V
NXF1	V				V		V
NXF3	V				V		V
NXF2	V	V	V
NXF2B	V	V	V
UTP6	V	V		V
CSNK2B	V				V		V
EIF6	V	V		V
NOP10									V	V
RIOK2									V	V
+ 2.3 Folding, sorting and degradation	5.4	3.7	0.9	4.3	5.1	2.2	4.7	1.7	0.6	1.2
+ 03060: Protein export	1.1	0.6	0	1	1.8	0	2	0	0	0
OXA1L	V	V		V	V		V
SRP14	V				V		V
SRP72	V	V		V
SPCS2	V				V		V
+ 04141: Protein processing in endoplasmic reticulum	3.4	2.3	0.7	2.5	3.3	0.4	3.6	1.2	1.1	1.1
ATF4	V	V	V
CANX	V	V		V
PDIA3	V	V		V
CAPN1	V	V	V
SEC24B	V	V		V	V	V
SEC23B	V				V		V
SEC23A	V	V		V	V		V
LMAN1	V	V		V
MAN1C1	V	V		V
SYVN1	V				V		V
UBE2G2	V	V		V
ERN1	V				V		V
EIF2AK3	V	V		V
XBP1	V				V		V
HSPA1A	V				V		V
HSPA1B	V				V		V
HSPA8	V	V		V	V		V
HERPUD1	V				V		V
UBE2D2	V	V		V
DNAJC5	V				V		V
DNAJC10	V				V		V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
SAR1A	V				V		V
HSP90B1	V				V		V
BCL2	V	V		V
LMAN1L	V	V	V
HSPH1	V	V		V
BAG1	V				V		V
BAG2	V	V		V
SIL1	V	V	V
CKAP4	V	V	V		V		V		V
SSR3	V	V		V
CALR								V
PRKN								V
SSR2									V	V
DNAJB2										V
+ 04130: SNARE interactions in vesicular transport	0	0.1	0	0.2	0	0	0	0	0	0
BET1	V	V		V
+ 04120: Ubiquitin mediated proteolysis	4.7	4.9	0.1	6	1.8	1.1	1.5	2	0.6	2
UBA2	V	V		V	V		V
KEAP1	V	V		V
SOCS3	V				V	V		V
HERC3	V	V		V
UBE2F	V				V		V
CDC23	V	V		V
CDC16	V	V		V
ANAPC5	V	V		V
CDC27	V	V		V	V	V
CDC20	V	V	V
CUL5	V	V		V
CUL4B	V	V		V
CUL4A	V	V		V
TRIM32	V	V		V
SYVN1	V				V		V
PIAS1	V	V		V
BIRC3	V	V		V
XIAP	V	V		V
CBLB	V	V		V
PRPF19	V	V		V
UBE3A	V	V		V
UBE2D2	V	V		V
UBE2N	V	V		V
UBE3B	V				V		V
UBE2S	V				V		V
UBE2C	V	V	V						V	V
UBE2K	V	V		V
UBE2G2	V	V		V
UBE2R2	V				V		V
HERC1	V	V		V	V		V
UBR5	V	V		V
UBE4A	V	V		V
HUWE1	V	V		V
UBE2I	V				V		V	V
UBE2E1	V	V		V
PRKN								V
NEDD4L										V
NEDD4										V
+ 04122: Sulfur relay system	1.9	1.6	1.3	1	1	0	1.1	0	0	0
MOCS3	V				V		V
TST	V	V	V
MOCS2	V	V		V
+ 03050: Proteasome	1.8	0	0.4	0	3.4	2.8	2.3	1.2	0	0
PSMD3	V				V	V
PSMD12	V				V	V
PSMD4	V	V	V
PSMC4	V				V		V
PSMC5	V				V		V
PSME1	V				V		V
PSMB5	V				V		V
PSMB4	V				V		V
PSMB10	V				V	V
IFNG								V
+ 03018: RNA degradation	1.4	0.2	0	0.7	2.3	1.6	1.9	0	0	0
ENO1	V				V		V
DIS3	V				V		V
EXOSC5	V	V		V
C1D	V	V		V
ZCCHC7	V				V		V
CNOT8	V	V		V
DCP2	V				V		V
LSM8	V	V		V
TOB1	V				V	V
PABPC1	V				V		V
PABPC4	V				V		V
PFKM	V				V	V
+ 2.4 Replication and repair	5.4	4.5	0.3	6	4.2	0	4.8	0	0	0
+ 03030: DNA replication	1.6	1.1	0	1.7	1.8	0	2	0	0	0
POLD3	V				V		V
POLE3	V	V		V
SSBP1	V	V		V
POLD2	V				V		V
MCM7	V				V		V
RPA1	V	V		V
RPA2	V	V		V	V		V
+ 03410: Base excision repair	3	1.6	0	2.3	2.5	0	2.7	0	0	0
APEX1	V				V		V
PARP2	V	V		V
PARP1	V				V		V
POLE3	V	V		V
POLD3	V				V		V
POLD2	V				V		V
POLB	V	V		V
MUTYH	V	V		V
MPG	V				V		V
TDG	V	V		V
+ 03420: Nucleotide excision repair	2.1	1.9	0	2.7	1.4	0	1.7	0	0	0
ERCC3	V	V		V
CUL4B	V	V		V
CUL4A	V	V		V
POLE3	V	V		V
POLD3	V				V		V
POLD2	V				V		V
RPA1	V	V		V
RPA2	V	V		V	V		V
ERCC1	V				V		V
XPA	V	V		V
+ 03430: Mismatch repair	3.4	3.2	0	4	2.4	0	2.6	0	0	0
MSH2	V	V		V
MLH1	V	V		V	V		V
POLD3	V				V		V
POLD2	V				V		V
RPA1	V	V		V
RPA2	V	V		V	V		V
MSH6	V	V		V
MSH3	V	V		V
SSBP1	V	V		V
+ 03440: Homologous recombination	2.1	2.1	0.4	2.5	1.1	0	1.3	0	0	0
RAD51D	V	V		V
RPA1	V	V		V
RPA2	V	V		V	V		V
RAD51	V	V	V
RAD54B	V	V		V
POLD3	V				V		V
POLD2	V				V		V
SSBP1	V	V		V
ATM	V	V		V
+ 03450: Non-homologous end-joining	0.8	0.5	0	0.7	0.8	0	0.9	0	0	0
POLM	V	V		V
XRCC5	V				V		V
+ 03460: Fanconi anemia pathway	1.4	1.6	0.3	2	1.2	0	1.5	0	0	0
FANCF	V	V		V
RPA1	V	V		V
RPA2	V	V		V	V		V
MLH1	V	V		V	V		V
USP1	V				V		V
REV3L	V	V		V
POLI	V	V		V
ERCC1	V				V		V
RAD51	V	V	V
+ 3. Environmental Information Processing	10.3	9.8	8.2	6.8	6	4.3	5.2	13	2	2.3
+ 3.1 Membrane transport	0.8	1.1	0.9	0.9	0.2	1.1	0	1.2	0	0
+ 02010: ABC transporters	0.8	1.1	0.9	0.9	0.2	1.1	0	1.2	0	0
ABCG1	V	V		V
ABCD2	V	V		V
ABCB1	V	V		V
ABCB9	V	V	V
ABCA7	V				V	V
ABCA3	V	V	V
ABCA4								V
+ 3.2 Signal transduction	12.8	11.2	8.3	8.4	8.8	4.7	8	13.4	1.9	2.4
+ 04010: MAPK signaling pathway	3	2.2	2.1	1.3	2.1	1.3	1.8	4.9	0.2	0.2
DUSP6	V				V		V
FASLG	V	V		V
STMN1	V				V		V
MAP2K1	V				V	V
RASA1	V	V		V
NF1	V				V		V
PRKCA	V	V		V				V
PRKACA	V				V		V
PRKACB	V	V		V
RASA2	V	V		V	V	V
RASGRP1	V	V		V
RASGRP2	V				V		V
IGF1R	V				V		V
INSR	V	V	V
PDGFRB	V				V	V
CACNA2D3	V	V		V
CACNB3	V				V	V
ATF4	V	V	V
TP53	V	V		V
ATF2	V	V		V				V
MAPK14	V	V	V					V
AKT2	V				V		V
MAP3K4	V	V		V
MAP3K7	V	V		V
MAP3K13	V	V	V
GADD45A	V	V	V
GADD45B	V	V	V
TGFBR2	V	V		V
IL1R1	V	V	V
TGFB3	V				V		V
IL1B	V				V		V
TNF	V	V	V					V
PAK1	V				V		V
MAP3K3	V				V		V
MAP2K4	V				V		V
ARRB1	V	V		V
HSPA1A	V				V		V
HSPA1B	V				V		V
HSPA8	V	V		V	V		V
FLNB	V	V		V
MAP4K3	V	V		V
MYC	V	V		V
RPS6KA1	V				V		V
CSF1	V	V	V
EFNA1	V	V	V
ANGPT2	V	V	V
PDGFC	V	V	V
VEGFC	V	V	V
PDGFD	V	V		V
IRAK1	V	V	V
MAPK1								V
PRKCB								V
EGFR								V
CASP3								V
CD14								V
CRK								V
MAP3K8								V
MAP2K6									V
EPHA2										V
+ 04012: ErbB signaling pathway	2.2	1.3	0.8	1.2	1.7	0.7	1.7	3.8	0	0
GSK3B	V	V	V
CDKN1B	V	V		V
BUB1B-PAK6	V				V		V
PAK6	V				V		V
PAK1	V				V		V
NCK1	V	V		V
MAP2K4	V				V		V
CBLB	V	V		V
SHC3	V	V	V
PRKCA	V	V		V				V
CAMK2D	V				V		V
PLCG1	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
MYC	V	V		V
MAP2K1	V				V	V
EGFR								V
CRK								V
PRKCB								V
MAPK1								V
+ 04014: Ras signaling pathway	3.2	2.8	1.9	2.2	2.9	1.1	2.8	2.6	0.3	0.8
MAP2K1	V				V	V
AKT2	V				V		V
PIK3CB	V	V	V
SHC3	V	V	V
CSF1	V	V	V
EFNA1	V	V	V
ANGPT2	V	V	V
PDGFC	V	V	V
VEGFC	V	V	V
PDGFD	V	V		V
IGF1R	V				V		V
INSR	V	V	V
PDGFRB	V				V	V
GAB2	V	V	V		V		V
PTPN11	V	V		V
TIAM1	V	V		V	V		V
RALA	V				V		V
PRKCA	V	V		V				V
FASLG	V	V		V
RALBP1	V				V		V
ETS1	V	V		V
RASGRP1	V	V		V
RASGRP2	V				V		V
RASA4B	V	V		V
RASA4	V	V		V
RASA3	V	V		V
RASA1	V	V		V
RASA2	V	V		V	V	V
NF1	V				V		V
RHOA	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
PLCG1	V	V		V
BUB1B-PAK6	V				V		V
PAK6	V				V		V
PAK1	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
MAPK1								V
EGFR								V
PRKCB								V
BCL2L1								V
PLA2G2A									V	V
EPHA2										V
+ 04015: Rap1 signaling pathway	3.9	3	3.4	1.2	3.3	2.3	2.6	3.2	0.9	0.9
MAP2K1	V				V	V
CSF1	V	V	V
EFNA1	V	V	V
ANGPT2	V	V	V
PDGFC	V	V	V
VEGFC	V	V	V
PDGFD	V	V		V
IGF1R	V				V		V
INSR	V	V	V
PDGFRB	V				V	V
MAPK14	V	V	V					V
ENAH	V				V	V
PFN1	V				V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
SIPA1L1	V				V	V
SIPA1	V				V		V
RALA	V				V		V
ITGAM	V	V	V
F2R	V	V		V
FPR1	V	V	V
GNAS	V	V	V		V		V
RAPGEF6	V	V		V
VAV1	V				V		V
TIAM1	V	V		V	V		V
RHOA	V				V		V
PRKD3	V	V		V
KRIT1	V	V		V
RASGRP2	V				V		V
ADCY7	V				V		V
DRD2	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
TLN1	V				V		V
ITGA2B	V	V	V
FYB1	V				V	V
SKAP1	V	V		V
PRKCA	V	V		V				V
PLCG1	V	V		V
ID1	V	V	V
MAPK1								V
EGFR								V
CRK								V
PRKCB								V
MAP2K6									V
EPHA2										V
+ 04310: Wnt signaling pathway	1.6	1.9	1.1	1.7	0.2	0	0.4	1.2	0.5	0.5
SMAD3	V	V		V
PRKCA	V	V		V				V
CAMK2D	V				V		V
RHOA	V				V		V
CCND2	V	V		V
MYC	V	V		V
SMAD4	V	V		V
LEF1	V	V		V
EP300	V	V		V
MAP3K7	V	V		V
CSNK1A1	V
TBL1X	V	V	V
TP53	V	V		V
AXIN1	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
GSK3B	V	V	V
FRAT1	V	V	V
CSNK2B	V				V		V
WNT1	V	V	V
WNT8B	V	V	V
BAMBI	V	V	V
SERPINF1	V	V		V
RYK	V	V		V
PRKCB								V
CHD8									V	V
+ 04330: Notch signaling pathway	1	1	0.3	1.3	0.9	0	1.1	1.2	0	0
NCSTN	V				V		V
HDAC1	V	V		V
HDAC2	V	V		V
EP300	V	V		V
KAT2A	V	V		V
NOTCH1	V				V		V
NOTCH3	V	V	V		V		V
ADAM17								V
+ 04340: Hedgehog signaling pathway	1.7	1.9	0.3	2.2	0.2	0	0.2	0	1.2	1.2
CSNK1A1	V
GSK3B	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
PTCH1	V	V		V
ARRB1	V	V		V
SPOP	V	V		V
CCND2	V	V		V
BCL2	V	V		V
SHH									V	V
+ 04350: TGF-beta signaling pathway	2.6	2.2	1.6	1.7	1.5	0.7	1.5	2.4	0	1.6
LTBP1	V	V	V							V
SMAD4	V	V		V
SMAD3	V	V		V
SMAD7	V	V		V
EP300	V	V		V
MYC	V	V		V
ID1	V	V	V
ID2	V				V		V
ID3	V	V		V
INHBA	V	V	V		V		V
INHBB	V				V	V
PPP2R1A	V				V		V
RHOA	V				V		V
TGFBR2	V	V		V
TGFB3	V				V		V
TNF	V	V	V					V
BAMBI	V	V	V
TGIF2	V				V		V
TGIF1	V	V		V
MAPK1								V
IFNG								V
SP1										V
+ 04390: Hippo signaling pathway	1.5	1.6	1.9	0.8	0.4	0	0.7	0	1.2	1.2
BIRC5	V	V	V
YWHAQ	V				V		V
DLG3	V				V		V
LIMD1	V	V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
SMAD3	V	V		V
TGFB3	V				V		V
TGFBR2	V	V		V
SMAD4	V	V		V
SMAD7	V	V		V
WNT1	V	V	V
WNT8B	V	V	V
GSK3B	V	V	V
AXIN1	V				V		V
LEF1	V	V		V
MYC	V	V		V
CCND2	V	V		V
SNAI2	V	V	V
ID1	V	V	V
ID2	V				V		V
PPP2R1A	V				V		V
AFP									V	V
+ 04392: Hippo signaling pathway - multiple species	0.4	0.1	0	0.3	0.9	1.3	0.4	0	0	0
PAK1	V				V		V
FAT4	V				V	V
LIMD1	V	V		V
+ 04370: VEGF signaling pathway	0.4	0.4	0.7	0.3	0.3	0.9	0.1	3.6	0	0
PLCG1	V	V		V
AKT2	V				V		V
PIK3CB	V	V	V
PRKCA	V	V		V				V
MAPK14	V	V	V					V
MAP2K1	V				V	V
PRKCB								V
MAPK1								V
+ 04371: Apelin signaling pathway	2.7	2.9	1.7	2.4	2.4	0.5	2.5	0.6	0	0
PRKAB1	V	V		V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
PIK3R5	V	V		V	V		V
AKT2	V				V		V
MAP2K1	V				V	V
ITPR1	V	V		V
RYR2	V	V	V
MYLK	V	V	V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
PDE3B	V	V		V
MEF2D	V	V	V
GNA13	V	V		V
GABARAPL2	V				V		V
EGR1	V	V	V
NOTCH3	V	V	V		V		V
SMAD4	V	V		V
SMAD3	V	V		V
RPS6	V				V		V
CAMK4	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
MAPK1								V
+ 04064: NF-kappa B signaling pathway	5.1	5.1	2.7	4.2	1.1	0	1.4	4.8	0	0
BCL2	V	V		V
BIRC3	V	V		V
NFKBIA	V	V	V
IRAK1	V	V	V
TRAF5	V	V		V
RIPK1	V	V		V
IL1R1	V	V	V
IL1B	V				V		V
TNF	V	V	V					V
MAP3K7	V	V		V
CD40LG	V	V		V
PLCG1	V	V		V
PRKCQ	V	V		V
MALT1	V	V		V
TRAF1	V	V		V
CSNK2B	V				V		V
BCL2A1	V	V	V
LYN	V	V	V
LCK	V	V		V
BLNK	V	V		V
ATM	V	V		V
PARP1	V				V		V
UBE2I	V				V		V	V
XIAP	V	V		V
GADD45B	V	V	V
CXCL2	V	V	V
CCL19	V				V		V
LTB	V	V		V
EDAR	V	V		V
CYLD	V				V		V
BCL2L1								V
PRKCB								V
CXCL8								V
CD14								V
TRIM25								V
+ 04668: TNF signaling pathway	4.2	3.4	4	1.1	1.9	2.6	0.9	8.8	0.7	0.7
TNF	V	V	V					V
TRAF5	V	V		V
RIPK1	V	V		V
BIRC3	V	V		V
MAP3K7	V	V		V
MAP2K4	V				V		V
MAPK14	V	V	V					V
NFKBIA	V	V	V
MAP2K1	V				V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
CASP8	V	V		V
CCL2	V				V	V		V
CXCL1	V	V	V					V
CXCL2	V	V	V
CSF1	V	V	V
CSF2	V	V	V
IL1B	V				V		V
BCL3	V	V	V
SOCS3	V				V	V		V
TRAF1	V	V		V
MMP9	V	V	V
VEGFC	V	V	V
TNFRSF1B	V				V		V
PIK3CB	V	V	V
AKT2	V				V		V
BAG4	V				V		V			V
MAP3K8								V
MAPK1								V
CREB1								V
CASP3								V
CCL5								V
CXCL10								V
IL18R1								V
IL6								V
RIPK3								V
IFNB1								V
MAP2K6									V
+ 04066: HIF-1 signaling pathway	2.7	1.4	1.4	0.9	2.7	0.6	2.8	4.7	2.2	2.2
EGLN1	V				V		V
EP300	V	V		V
IGF1R	V				V		V
INSR	V	V	V
PIK3CB	V	V	V
AKT2	V				V		V
PLCG1	V	V		V
PRKCA	V	V		V				V
LDHB	V	V		V
CAMK2D	V				V		V
HK1	V				V		V		V	V
GAPDH	V	V	V		V		V	V
ALDOA	V				V		V
ENO1	V				V		V
PFKFB3	V	V	V
ANGPT2	V	V	V
TIMP1	V				V		V
RPS6	V				V		V
MAP2K1	V				V	V
BCL2	V	V		V
CDKN1B	V	V		V
EGFR								V
PRKCB								V
IFNG								V
IL6								V
MAPK1								V
HKDC1									V	V
TF									V	V
+ 04068: FoxO signaling pathway	4.8	4.8	2.9	3.7	1.5	0.5	1.6	3.3	0	0
PRKAB1	V	V		V
FOXO1	V	V		V
FOXO3	V	V	V
MAP2K1	V				V	V
INSR	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
IRS2	V	V	V
EP300	V	V		V
SIRT1	V	V		V
IGF1R	V				V		V
CCNB2	V	V	V
CCND2	V	V		V
CDKN1B	V	V		V
RBL2	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
FASLG	V	V		V
BCL2L11	V				V		V
BCL6	V	V	V
SOD2	V				V		V
ATM	V	V		V
IL7R	V	V		V	V		V
S1PR1	V	V		V
HOMER2	V	V	V
GABARAPL2	V				V		V
ATG12	V	V		V
C8orf44-SGK3	V	V		V
SGK3	V	V		V
SGK1	V				V		V
TGFBR2	V	V		V
SMAD3	V	V		V
SMAD4	V	V		V
MAPK14	V	V	V					V
TGFB3	V				V		V
MAPK1								V
EGFR								V
IL6								V
IL10								V
+ 04020: Calcium signaling pathway	2	1.9	0.8	2	2.2	0.8	2.2	1.7	0.4	0
ITPKB	V	V		V	V		V
VDAC1	V	V		V
VDAC2	V				V		V
PPIF	V	V	V						V
CAMK4	V	V		V
CAMK2D	V				V		V
PRKCA	V	V		V				V
PDGFRB	V				V	V
GNA15	V	V	V
GRIN2D	V	V	V
P2RX5	V	V		V
PLCG1	V	V		V
MYLK	V	V	V
ITPR1	V	V		V
RYR2	V	V	V
F2R	V	V		V
CXCR4	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
SLC25A5	V				V		V
SLC25A6	V				V		V
ADCY7	V				V		V
ADRB2	V	V		V
PLN	V				V	V
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
ATP2B1	V	V		V
ATP2B4	V	V		V	V		V
PRKCB								V
EGFR								V
+ 04070: Phosphatidylinositol signaling system	2.9	2.7	1	2.6	2.9	0.6	2.9	2.4	0	0.7
PLCG1	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
ITPR1	V	V		V
PIK3CB	V	V	V
PIP5K1B	V				V		V
DGKA	V	V		V
DGKG	V	V		V
DGKD	V				V		V
INPP4A	V	V		V
PIP4K2A	V				V		V
IMPA1	V	V		V
IMPA2	V	V	V		V		V
INPP5A	V	V	V
INPP5K	V				V		V
ITPK1	V	V	V
ITPKB	V	V		V	V		V
MTMR6	V				V		V
IP6K3	V				V	V
PRKCA	V	V		V				V
PI4KB								V
PRKCB								V
CDS1										V
+ 04072: Phospholipase D signaling pathway	3.1	2.4	1.9	1.6	2.5	1.6	2	3.2	0.5	0.5
MAP2K1	V				V	V
AKT2	V				V		V
PIK3CB	V	V	V
SHC3	V	V	V
INSR	V	V	V
PDGFRB	V				V	V
GAB2	V	V	V		V		V
PTPN11	V	V		V
RALA	V				V		V
RHOA	V				V		V
LPAR6	V	V		V
F2R	V	V		V
CXCR1	V	V	V
CXCR2	V	V	V
PLCG1	V	V		V
PRKCA	V	V		V				V
TSC2	V				V	V
PIP5K1B	V				V		V
GNA13	V	V		V
PIK3R5	V	V		V	V		V
CYTH1	V				V		V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PLPP1	V	V		V
DGKA	V	V		V
DGKG	V	V		V
DGKD	V				V		V
PDGFC	V	V	V
PDGFD	V	V		V
MAPK1								V
EGFR								V
CXCL8								V
AGT								V	V	V
+ 04071: Sphingolipid signaling pathway	2.2	1.8	0.8	1.9	1.7	0.5	1.8	3.4	0	0
MAP2K1	V				V	V
AKT2	V				V		V
PIK3CB	V	V	V
PRKCA	V	V		V				V
S1PR1	V	V		V
S1PR5	V	V		V
GNA13	V	V		V
RHOA	V				V		V
TNF	V	V	V					V
CERS2	V				V		V
ASAH1	V				V		V
PPP2R1A	V				V		V
PPP2R5C	V	V		V	V		V
PPP2R5D	V				V		V
PPP2R5E	V	V		V
SGPP1	V	V		V
MAPK14	V	V	V					V
TP53	V	V		V
BCL2	V	V		V
GAB2	V	V	V		V		V
KNG1	V	V		V
MAPK1								V
PRKCB								V
+ 04024: cAMP signaling pathway	2.2	2.1	1.2	1.9	2.2	1.2	1.9	1	0	0
RYR2	V	V	V
ADRB2	V	V		V
DRD2	V	V		V
HTR1F	V	V	V
HCAR3	V	V	V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
PLN	V				V	V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
ATP2B1	V	V		V
ATP2B4	V	V		V	V		V
MAP2K1	V				V	V
CREB5	V				V	V
RHOA	V				V		V
CAMK4	V	V		V
CAMK2D	V				V		V
PDE3B	V	V		V
PDE4B	V	V		V
EP300	V	V		V
GRIA4	V	V		V
GRIN2D	V	V	V
NFKBIA	V	V	V
PTCH1	V	V		V
F2R	V	V		V
MYL9	V	V	V
TIAM1	V	V		V	V		V
VAV1	V				V		V
PAK1	V				V		V
MAPK1								V
CREB1								V
+ 04022: cGMP-PKG signaling pathway	2.7	2.4	1.7	1.9	2.4	1.5	2	1.8	0.5	0
MYL9	V	V	V
ITPR1	V	V		V
RHOA	V				V		V
MEF2D	V	V	V
PLN	V				V	V
MAP2K1	V				V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
ATP2B1	V	V		V
ATP2B4	V	V		V	V		V
PIK3R5	V	V		V	V		V
AKT2	V				V		V
ADCY7	V				V		V
PDE3B	V	V		V
PPIF	V	V	V						V
SLC25A5	V				V		V
SLC25A6	V				V		V
VDAC1	V	V		V
VDAC2	V				V		V
MYLK	V	V	V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
IRS2	V	V	V
INSR	V	V	V
ADRB2	V	V		V
GNA13	V	V		V
KNG1	V	V		V
NPPC	V	V	V
MAPK1								V
CREB1								V
+ 04151: PI3K-Akt signaling pathway	4.4	4	3.3	2.5	2.2	2	1.6	5.3	0.5	1.4
RPS6	V				V		V
EIF4B	V	V		V
TSC2	V				V	V
AKT2	V				V		V
PIK3CB	V	V	V
IGF1R	V				V		V
INSR	V	V	V
PDGFRB	V				V	V
LPAR6	V	V		V
F2R	V	V		V
GSK3B	V	V	V
MYC	V	V		V
CDKN1B	V	V		V
RBL2	V	V		V
FASLG	V	V		V
BCL2L11	V				V		V
FOXO3	V	V	V
TP53	V	V		V
YWHAQ	V				V		V
CSF1	V	V	V
EFNA1	V	V	V
ANGPT2	V	V	V
PDGFC	V	V	V
VEGFC	V	V	V
PDGFD	V	V		V
PPP2R1A	V				V		V
PPP2R5C	V	V		V	V		V
PPP2R5D	V				V		V
PPP2R5E	V	V		V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
HSP90B1	V				V		V
PIK3R5	V	V		V	V		V
MAP2K1	V				V	V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
ITGA6	V	V		V
ITGA2B	V	V	V
ITGA4	V	V		V
ITGB4	V	V	V
CHAD	V	V	V
COL1A1	V	V	V
FN1	V				V	V		V
TNC	V	V	V
LAMA3	V				V	V			V	V
LAMA4	V				V		V
LAMB3	V	V	V
THBS4	V	V	V
TNXB	V				V		V
TLR2	V	V	V
IFNAR2	V	V	V
IL2RB	V	V		V
IL7R	V	V		V	V		V
JAK1	V				V		V
IFNA21	V	V		V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
BCL2	V	V		V
PRKCA	V	V		V				V
PKN2	V	V		V
C8orf44-SGK3	V	V		V
SGK3	V	V		V
SGK1	V				V		V
PIK3AP1	V				V		V
CCND2	V	V		V
TCL1A	V	V		V
EGFR								V
BCL2L1								V
MAPK1								V
VTN								V	V	V
IFNA1								V
IFNA13								V
IFNB1								V
IL2								V
IL6								V
CREB1								V
EPHA2										V
LAMC2										V
+ 04152: AMPK signaling pathway	2.9	2.1	2	1.2	2.4	1.9	1.8	0.7	0.6	0
PRKAB1	V	V		V
INSR	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
IRS2	V	V	V
IGF1R	V				V		V
FOXO1	V	V		V
FOXO3	V	V	V
SIRT1	V	V		V
CAMKK2	V	V	V		V		V
PFKFB3	V	V	V
PFKM	V				V	V
TSC2	V				V	V
SREBF1	V	V		V
SCD	V	V	V						V
PPP2R1A	V				V		V
PPP2R5C	V	V		V	V		V
PPP2R5D	V				V		V
PPP2R5E	V	V		V
RAB8A	V				V		V
RAB14	V	V		V
RAB2A	V				V		V
MAP3K7	V	V		V
CREB5	V				V	V
CREB1								V
+ 04150: mTOR signaling pathway	0.9	0.3	1.9	0	1.2	1	1	2.5	0	0
IGF1R	V				V		V
INSR	V	V	V
PIK3CB	V	V	V
MAP2K1	V				V	V
AKT2	V				V		V
TSC2	V				V	V
RHOA	V				V		V
PRKCA	V	V		V				V
SGK1	V				V		V
RRAGA	V				V		V
RRAGD	V	V	V
RPS6KA1	V				V		V
RPS6	V				V		V
TNF	V	V	V					V
GRB10	V	V	V
EIF4B	V	V		V
GSK3B	V	V	V
WNT1	V	V	V
WNT8B	V	V	V
MAPK1								V
PRKCB								V
+ 3.3 Signaling molecules and interaction	4.2	4.7	5	2.5	1.4	1.6	1	7.9	1.5	1.6
+ 04080: Neuroactive ligand-receptor interaction	0	0.4	1.4	0.1	0	0	0	0.2	0.5	0.2
CTSG	V	V	V		V		V
GRIA4	V	V		V
GRIN2D	V	V	V
P2RX5	V	V		V
GABRB3	V	V	V
GABRE	V	V	V
LTB4R	V	V	V
S1PR1	V	V		V
S1PR5	V	V		V
LPAR6	V	V		V
P2RY10	V	V		V
NMUR1	V	V	V
F2R	V	V		V
MC1R	V	V		V
MC3R	V	V	V
FPR1	V	V	V
C5AR1	V	V	V
C3AR1	V	V	V
AGTR2	V	V	V
HTR1F	V	V	V
DRD2	V	V		V
ADRB2	V	V		V
KNG1	V	V		V
ADM	V	V	V		V		V
AGT								V	V	V
CCK									V
+ 04060: Cytokine-cytokine receptor interaction	3	3.8	2.9	2.6	0.4	0.4	0.5	7.2	0	0
IL2RB	V	V		V
CSF2RB	V	V	V
IL6ST	V	V		V
IL1R2	V	V	V
IL1R1	V	V	V
TGFBR2	V	V		V
IL1B	V				V		V
INHBB	V				V	V
INHBA	V	V	V		V		V
TGFB3	V				V		V
EDAR	V	V		V
CD27	V	V		V
TNFSF8	V	V		V
CD40LG	V	V		V
FASLG	V	V		V
LTB	V	V		V
IL20RA	V	V	V
IL10RA	V	V		V	V		V
IFNAR2	V	V	V
IFNA21	V	V		V
IL7R	V	V		V	V		V
IL21R	V	V		V
CSF2	V	V	V
IL13RA1	V	V	V
CXCR5	V	V		V
CXCR4	V				V		V
CXCR1	V	V	V
CXCR2	V	V	V
XCL2	V	V		V
XCL1	V	V		V
PPBP	V	V	V
TNFRSF1B	V				V		V
TNFRSF21	V	V		V
TNFRSF10D	V	V		V
TNF	V	V	V					V
CXCL1	V	V	V					V
CXCL2	V	V	V
CCR7	V	V		V
CCL19	V				V		V
CCR2	V				V		V
CCL2	V				V	V		V
CCL8	V	V		V
CCR6	V	V		V
IL1RN	V	V	V
IL16	V	V		V
IL32	V				V		V
CSF1	V	V	V
CD4	V	V		V
TNFRSF25	V	V		V
BMP3	V	V	V
IL18R1								V
IL10								V
IFNG								V
IFNB1								V
IFNA1								V
IFNA13								V
THPO								V
IL2								V
IL12RB1								V
IL6								V
CXCL10								V
CXCL8								V
CXCL6								V
CCL5								V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	3.4	3.5	2.7	2.3	1.1	0.6	1	6.8	0	0
CCL8	V	V		V
CCL2	V				V	V		V
CCR2	V				V		V
CCR6	V	V		V
CCL19	V				V		V
CCR7	V	V		V
CXCL1	V	V	V					V
CXCL2	V	V	V
CXCR1	V	V	V
PPBP	V	V	V
CXCR2	V	V	V
CXCR5	V	V		V
CXCR4	V				V		V
XCL1	V	V		V
XCL2	V	V		V
IL10RA	V	V		V	V		V
IL6ST	V	V		V
IL2RB	V	V		V
IL20RA	V	V	V
CSF1	V	V	V
TNFRSF1B	V				V		V
TNF	V	V	V					V
TNFRSF10D	V	V		V
CCL5								V
CXCL8								V
CXCL6								V
CXCL10								V
IL10								V
IL6								V
IL2								V
IL18R1								V
+ 04512: ECM-receptor interaction	2.1	1.6	3	0.1	1.3	2.2	0.5	1.7	2.4	3.1
LAMA3	V				V	V			V	V
LAMA4	V				V		V
LAMB3	V	V	V
COL1A1	V	V	V
TNC	V	V	V
TNXB	V				V		V
GP1BA	V	V	V
FN1	V				V	V		V
THBS4	V	V	V
ITGA6	V	V		V
ITGA4	V	V		V
SDC1	V				V	V
ITGB4	V	V	V
ITGA2B	V	V	V
CHAD	V	V	V
CD44	V				V		V
VTN								V	V	V
SDC4									V	V
LAMC2										V
+ 4. Cellular Processes	14.1	11.1	9.8	7.1	9.6	4.8	8.7	8.8	3.5	3.9
+ 4.1 Transport and catabolism	6.9	4.3	3.7	3.2	6.2	1.6	6.3	4.3	2.2	2.9
+ 04144: Endocytosis	4	1.4	0.6	1.5	4.4	0.2	4.9	1.4	0.8	0.8
STAM2	V	V		V
USP8	V	V		V
CBLB	V	V		V
AP2B1	V				V		V
HSPA1A	V				V		V
HSPA1B	V				V		V
HSPA8	V	V		V	V		V
CHMP4B	V				V		V
CHMP2A	V	V	V
VPS4B	V				V		V
RAB11A	V				V		V
EPS15	V				V		V
LDLRAP1	V				V		V
CXCR1	V	V	V
CXCR2	V	V	V
CXCR4	V				V		V
IGF1R	V				V		V
SH3KBP1	V				V		V
SH3GLB2	V	V		V
GRK4	V	V	V
GRK6	V	V	V
ARRB1	V	V		V
RAB11FIP1	V				V		V
PIP5K1B	V				V		V
EEA1	V	V		V
ARFGEF2	V	V		V
ARFGEF1	V	V		V
CYTH1	V				V		V
ARFGAP3	V				V		V
GIT2	V				V		V
HLA-B	V				V		V	V
HLA-F	V	V		V
TGFBR2	V	V		V
SMAD3	V	V		V
CAV2	V				V		V
IL2RB	V	V		V
RHOA	V				V		V
FOLR3	V	V	V
KIF5C	V	V		V
SNX4	V	V		V
RAB31	V	V	V
VPS35	V				V		V
RAB8A	V				V		V
RAB11FIP3	V				V	V
AMPH	V				V		V
ARPC5	V				V		V
SNX12	V				V		V
SNX5	V	V		V
SNX6	V				V		V
EGFR								V
HLA-A								V
ARF3									V
ARF5									V
NEDD4L										V
NEDD4										V
+ 04145: Phagosome	3.3	2.3	4.3	0.1	2.7	1	2.6	5.2	1.8	2.5
FCGR3B	V	V	V		V	V
FCGR2C	V				V		V
ITGAM	V	V	V
ACTB	V	V	V						V	V
ACTG1	V	V	V
EEA1	V	V		V
NCF4	V	V	V
NCF1	V	V	V
NCF2	V				V		V
DYNC1H1	V				V	V
DYNC1I2	V				V		V
TUBA1A	V	V	V		V		V
TUBB3	V	V	V
TUBB4B	V	V	V
TCIRG1	V	V	V
ATP6V0B	V				V		V
LAMP2	V				V		V
MPO	V	V	V
MARCO	V	V	V
OLR1	V	V	V
TLR2	V	V	V
THBS4	V	V	V
CANX	V	V		V
HLA-DMB	V				V		V
HLA-DOB	V	V		V
HLA-DPA1	V				V		V
HLA-DPB1	V				V		V
HLA-DQA2	V				V		V
CTSS	V				V		V
HLA-B	V				V		V	V
HLA-F	V	V		V
CD14								V
MBL2								V
CALR								V
HLA-DRB1								V
CLEC4M								V
CD209								V
CTSL								V	V	V
HLA-A								V
ATP6V0A4									V	V
CYBA										V
+ 04142: Lysosome	4.1	2.5	3.4	0.6	4.5	1.2	4.4	0.7	2.7	2.7
TCIRG1	V	V	V
ATP6V0B	V				V		V
CTSG	V	V	V		V		V
CTSO	V	V		V
CTSS	V				V		V
CTSZ	V	V	V
CTSA	V	V	V
TPP1	V				V		V
GLA	V	V	V
GLB1	V				V		V
HEXA	V				V	V
ARSA	V	V	V
GNS	V	V		V	V		V
IDS	V				V		V
GALNS	V	V	V
LIPA	V				V		V
ASAH1	V				V		V
GNPTG	V				V		V
GM2A	V	V		V	V	V
PSAP	V				V		V		V
LAMP2	V				V		V
CD63	V	V	V		V		V
ABCB9	V	V	V
SLC11A2	V	V		V
SLC11A1	V	V	V
NPC2	V				V		V
CD164	V	V		V	V		V
ENTPD4	V				V		V
AP1M2	V	V	V
AP4E1	V	V		V
CTSL								V	V	V
ATP6V0A4									V	V
AGA									V	V
NEU1										V
+ 04146: Peroxisome	2.6	2	0.1	2.8	1.4	0	1.8	0	0	0
PEX2	V	V		V
PEX1	V	V		V
PEX12	V	V		V
PEX11B	V	V		V
PEX3	V	V		V
HSD17B4	V				V		V
SCP2	V	V		V
AMACR	V	V		V
CROT	V	V		V
BAAT	V				V		V
ECI2	V	V		V
ABCD2	V	V		V
ACSL1	V	V	V
ACSL6	V				V		V
SOD1	V				V		V
SOD2	V				V		V
PRDX1	V				V		V
+ 04140: Autophagy - animal	2.4	1.1	0.7	1.1	2.5	1.8	2	2.1	0.6	0.6
IGF1R	V				V		V
IRS2	V	V	V
PIK3CB	V	V	V
AKT2	V				V		V
MAP2K1	V				V	V
TSC2	V				V	V
RRAGA	V				V		V
RRAGD	V	V	V
CAMKK2	V	V	V		V		V
MAP3K7	V	V		V
ERN1	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
ITPR1	V	V		V
BCL2	V	V		V
EIF2AK3	V	V		V
ATG12	V	V		V
ATG5	V	V		V
ATG16L2	V				V	V
PRKCQ	V	V		V
GABARAPL2	V				V		V
LAMP2	V				V		V
VMP1	V				V		V
MAPK1								V
BCL2L1								V
CTSL								V	V	V
+ 04136: Autophagy - other	0.4	0.4	0	0.7	0.3	0	0.4	0	0	0
GABARAPL2	V				V		V
ATG12	V	V		V
ATG5	V	V		V
+ 04137: Mitophagy - animal	1.6	1.6	0.6	1.7	0.6	0	0.8	1.9	0	1
USP8	V	V		V
OPTN	V	V		V
NBR1	V	V		V
GABARAPL2	V				V		V
CSNK2B	V				V		V
ATG5	V	V		V
TFE3	V				V		V
EIF2AK3	V	V		V
ATF4	V	V	V
TP53	V	V		V
FOXO3	V	V	V
PRKN								V
BCL2L1								V
SP1										V
+ 4.2 Cell growth and death	11.7	10.8	6.4	8.7	5.4	3.2	4.7	6.7	3.1	2.5
+ 04110: Cell cycle	5.6	6.4	3.4	5.3	0.7	1.8	0.2	0.7	0.6	0.6
MCM7	V				V		V
ORC3	V	V		V
ORC5	V	V		V
ANAPC5	V	V		V
CDC23	V	V		V
CDC16	V	V		V
CDC27	V	V		V	V	V
CDK1	V	V	V
BUB1B	V	V	V
ATM	V	V		V
DBF4	V	V		V
BUB3	V	V		V
CDC14A	V	V		V
YWHAQ	V				V		V
EP300	V	V		V
PTTG1	V	V	V
SMC1A	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
TP53	V	V		V
CDKN1B	V	V		V
CDKN1C	V	V		V
TGFB3	V				V		V
SMAD4	V	V		V
SMAD3	V	V		V
CDC20	V	V	V
CDC25A	V	V	V		V	V
GSK3B	V	V	V
CCNB2	V	V	V
CCND2	V	V		V
MAD1L1	V				V	V
TTK	V	V	V
CDKN2C	V	V	V
MYC	V	V		V
HDAC1	V	V		V
HDAC2	V	V		V
RBL2	V	V		V
RB1								V
STAG1									V	V
+ 04114: Oocyte meiosis	3.6	2.8	1.5	2.4	3.6	1.8	3.1	1.4	0.6	0.6
CDK1	V	V	V
MAD1L1	V				V	V
CCNB2	V	V	V
RPS6KA1	V				V		V
MAP2K1	V				V	V
ANAPC5	V	V		V
CDC23	V	V		V
CDC16	V	V		V
CDC27	V	V		V	V	V
CDC20	V	V	V
PTTG1	V	V	V
CAMK2D	V				V		V
ITPR1	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
PRKACA	V				V		V
PRKACB	V	V		V
ADCY7	V				V		V
YWHAQ	V				V		V
MAPK14	V	V	V					V
SMC1A	V	V		V
STAG3	V	V	V
PPP2R5C	V	V		V	V		V
PPP2R5D	V				V		V
PPP2R5E	V	V		V
PPP2R1A	V				V		V
IGF1R	V				V		V
MAPK1								V
AURKA									V	V
+ 04210: Apoptosis	4.9	5.3	4.2	3.3	0.9	0.5	0.9	3.3	1.3	1.3
ATM	V	V		V
TP53	V	V		V
BCL2	V	V		V
BIRC3	V	V		V
XIAP	V	V		V
BIRC5	V	V	V
DFFB	V	V		V
NFKBIA	V	V	V
CASP8	V	V		V
CAPN1	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
RIPK1	V	V		V
CSF2RB	V	V	V
TNF	V	V	V					V
FASLG	V	V		V
PARP2	V	V		V
PARP1	V				V		V
DIABLO	V	V		V
ERN1	V				V		V
GADD45A	V	V	V
GADD45B	V	V	V
BCL2A1	V	V	V
TRAF1	V	V		V
BCL2L11	V				V		V
CTSO	V	V		V
CTSS	V				V		V
CTSZ	V	V	V
EIF2AK3	V	V		V
ATF4	V	V	V
ITPR1	V	V		V
CASP2	V	V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
TUBA1A	V	V	V		V		V
MAP2K1	V				V	V
BCL2L1								V
CASP3								V
CTSL								V	V	V
MAPK1								V
+ 04215: Apoptosis - multiple species	1.8	2.2	0.5	2.4	0.3	0	0.4	2.5	0	0
BIRC3	V	V		V
XIAP	V	V		V
BIRC5	V	V	V
DIABLO	V	V		V
BCL2	V	V		V
CASP8	V	V		V
BCL2L11	V				V		V
CASP3								V
BCL2L1								V
+ 04216: Ferroptosis	4.6	1.8	0.4	2	4.5	2.1	3.9	0	1.2	1.2
TP53	V	V		V
GPX4	V				V		V
VDAC2	V				V		V
GCLC	V	V		V
PCBP1	V				V		V
PCBP2	V				V		V
FTL	V				V	V
ATG5	V	V		V
SLC39A14	V				V	V
SLC11A2	V	V		V
MAP1LC3B	V				V		V
NCOA4	V				V		V
PRNP	V				V		V
ACSL1	V	V	V
ACSL6	V				V		V
LPCAT3	V	V		V
TF									V	V
+ 04217: Necroptosis	5.3	4.3	3.4	2.8	2.8	0.4	3	5.1	2.9	2.4
TNF	V	V	V					V
TRAF5	V	V		V
IFNAR2	V	V	V
IFNA21	V	V		V
JAK1	V				V		V
FASLG	V	V		V
BIRC3	V	V		V
XIAP	V	V		V
CASP8	V	V		V
CYLD	V				V		V
RIPK1	V	V		V
STAT1	V	V		V
STAT2	V	V		V
STAT4	V	V		V
STAT6	V				V		V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
PYGL	V	V	V
GLUL	V	V	V		V		V
GLUD2	V	V		V
SLC25A5	V				V		V
SLC25A6	V				V		V
IL1B	V				V		V
FTL	V				V	V
CAPN1	V	V	V
HIST1H2AE	V	V	V
HIST1H2AB	V	V	V
HIST1H2AD	V	V	V
H2AFZ	V				V		V
HIST2H2AA4	V	V	V
HIST2H2AA3	V	V	V
HIST1H2AJ	V	V	V
HIST1H2AC	V	V	V						V	V
PARP2	V	V		V
PARP1	V				V		V
BCL2	V	V		V
CAMK2D	V				V		V
CHMP4B	V				V		V
CHMP2A	V	V	V
VPS4B	V				V		V
VDAC1	V	V		V
VDAC2	V				V		V
PPID	V	V		V					V
IFNA1								V
IFNA13								V
IFNB1								V
IFNG								V
RIPK3								V
NLRP3								V
CASP1								V
PPIA								V	V
H2AFX									V	V
HIST2H2AC									V	V
HIST2H2AB										V
+ 04115: p53 signaling pathway	3	3.6	2.4	2.7	0.2	0.8	0.1	1.9	0.9	0.9
GADD45A	V	V	V
GADD45B	V	V	V
MDM4	V	V		V
ATM	V	V		V
TSC2	V				V	V
RRM2B	V				V		V
RRM2	V	V	V						V	V
ZMAT3	V	V		V
TP53I3	V	V	V
CASP8	V	V		V
CDK1	V	V	V
TP53	V	V		V
CCND2	V	V		V
PERP	V	V		V
SESN1	V	V		V
CCNB2	V	V	V
BCL2	V	V		V
CASP3								V
BCL2L1								V
+ 04218: Cellular senescence	4.3	4.2	2.1	3.6	2.2	1.6	1.8	4.1	1.1	0
MYC	V	V		V
HIPK3	V	V		V
HIPK1	V				V		V
TP53	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
TSC2	V				V	V
FOXO3	V	V	V
SIRT1	V	V		V
MAP2K1	V				V	V
ETS1	V	V		V
CCND2	V	V		V
RBL2	V	V		V
MAPK14	V	V	V					V
ATM	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
CDC25A	V	V	V		V	V
HUS1	V	V		V
CDK1	V	V	V
CCNB2	V	V	V
CAPN1	V	V	V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
ITPR1	V	V		V
TGFB3	V				V		V
SMAD3	V	V		V
FOXO1	V	V		V
TGFBR2	V	V		V
HLA-B	V				V		V	V
HLA-F	V	V		V
SLC25A5	V				V		V
SLC25A6	V				V		V
VDAC1	V	V		V
VDAC2	V				V		V
PPID	V	V		V					V
MAPK1								V
RB1								V
IL6								V
CXCL8								V
HLA-A								V
MAP2K6									V
+ 4.3 Cellular community - eukaryotes	6.5	5.8	6.8	2.2	4	2.4	3.5	4.5	1.3	2.1
+ 04510: Focal adhesion	4.4	3.5	4.7	0.7	2.4	1.9	1.9	3.8	1.6	2.1
ITGB4	V	V	V
ITGA6	V	V		V
ITGA2B	V	V	V
ITGA4	V	V		V
FLNB	V	V		V
MYLK	V	V	V
MYL9	V	V	V
MYLPF	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
TLN1	V				V		V
ZYX	V	V	V		V		V
ACTN1	V	V	V
ARHGAP5	V	V		V
PRKCA	V	V		V				V
RHOA	V				V		V
CHAD	V	V	V
COL1A1	V	V	V
FN1	V				V	V		V
TNC	V	V	V
LAMA3	V				V	V			V	V
LAMA4	V				V		V
LAMB3	V	V	V
THBS4	V	V	V
TNXB	V				V		V
CAV2	V				V		V
BIRC3	V	V		V
XIAP	V	V		V
BCL2	V	V		V
CCND2	V	V		V
MAP2K1	V				V	V
IGF1R	V				V		V
PDGFRB	V				V	V
PDGFC	V	V	V
VEGFC	V	V	V
PDGFD	V	V		V
SHC3	V	V	V
BUB1B-PAK6	V				V		V
PAK6	V				V		V
PAK1	V				V		V
VAV1	V				V		V
GSK3B	V	V	V
ACTB	V	V	V						V	V
ACTG1	V	V	V
PRKCB								V
VTN								V	V	V
MAPK1								V
EGFR								V
CRK								V
LAMC2										V
+ 04520: Adherens junction	3.3	3.6	3.3	1.9	0.9	0	1.1	1.9	0.9	0.9
SMAD4	V	V		V
LEF1	V	V		V
MAP3K7	V	V		V
EP300	V	V		V
SMAD3	V	V		V
SNAI1	V	V	V
SNAI2	V	V	V
TGFBR2	V	V		V
INSR	V	V	V
IGF1R	V				V		V
CSNK2B	V				V		V
PTPN6	V	V	V		V		V
ACP1	V	V		V
RHOA	V				V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
ACTN1	V	V	V
NECTIN1	V	V	V
MAPK1								V
EGFR								V
+ 04530: Tight junction	2.4	1.9	3	0.4	2.1	0.9	2	0	0.5	1.7
TIAM1	V	V		V	V		V
RHOA	V				V		V
RAPGEF6	V	V		V
PPP2R1A	V				V		V
ACTN1	V	V	V
ACTB	V	V	V						V	V
ACTG1	V	V	V
MICALL2	V				V	V
RAB13	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
YBX3	V	V	V
SLC9A3R1	V				V		V
EZR	V				V		V
CLDN17	V	V	V
CLDN5	V	V	V
CLDN1	V				V	V
PRKAB1	V	V		V
TUBA1A	V	V	V		V		V
ARHGEF2	V	V		V
CTTN	V	V	V
RAB8A	V				V		V
MYL9	V	V	V
MYL6B	V	V	V
MYH8	V	V		V
MYH9	V				V		V
MYH11	V	V		V	V		V
MYL6	V	V	V
DLG3	V				V		V
NEDD4L										V
NEDD4										V
+ 04540: Gap junction	1.8	1.8	2.1	0.8	1.3	1.5	0.8	3.2	0	0
PRKCA	V	V		V				V
CDK1	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
TUBB3	V	V	V
TUBB4B	V	V	V
ADCY7	V				V		V
TUBA1A	V	V	V		V		V
MAP2K1	V				V	V
PDGFRB	V				V	V
PDGFC	V	V	V
PDGFD	V	V		V
GNAS	V	V	V		V		V
DRD2	V	V		V
ITPR1	V	V		V
PRKCB								V
MAPK1								V
EGFR								V
+ 04550: Signaling pathways regulating pluripotency of stem cells	2.7	2.1	2.1	1.2	2.3	1.1	2.1	1.3	0	0
WNT1	V	V	V
WNT8B	V	V	V
AXIN1	V				V		V
GSK3B	V	V	V
IL6ST	V	V		V
JAK1	V				V		V
PIK3CB	V	V	V
AKT2	V				V		V
INHBA	V	V	V		V		V
INHBB	V				V	V
SMAD3	V	V		V
MAP2K1	V				V	V
IGF1R	V				V		V
MAPK14	V	V	V					V
SMAD4	V	V		V
MYC	V	V		V
ID1	V	V	V
ID2	V				V		V
ID3	V	V		V
KAT6A	V				V		V
REST	V	V		V
HOXB1	V	V	V
ISL1	V	V		V
COMMD3-BMI1	V	V		V	V		V
BMI1	V	V		V	V		V
PCGF5	V				V		V
MAPK1								V
+ 4.5 Cell motility	3.1	1.3	2.7	0.1	3.5	2.3	2.8	2.1	0.3	0.3
+ 04810: Regulation of actin cytoskeleton	3.1	1.3	2.7	0.1	3.5	2.3	2.8	2.1	0.3	0.3
ARPC5	V				V		V
PFN1	V				V		V
ARHGEF4	V				V	V
NCKAP1	V				V		V
SSH2	V				V		V
CFL1	V	V	V
GSN	V	V	V		V		V
PIP4K2A	V				V		V
PIP5K1B	V				V		V
ACTN1	V	V	V
EZR	V				V		V
MYL9	V	V	V
MYLPF	V	V	V
MYLK	V	V	V
ENAH	V				V	V
BUB1B-PAK6	V				V		V
PAK6	V				V		V
PAK1	V				V		V
RHOA	V				V		V
TIAM1	V	V		V	V		V
VAV1	V				V		V
MAP2K1	V				V	V
PIK3CB	V	V	V
ITGA6	V	V		V
ITGA2B	V	V	V
ITGA4	V	V		V
ITGAM	V	V	V
ITGB4	V	V	V
FN1	V				V	V		V
GNA13	V	V		V
PDGFRB	V				V	V
PDGFC	V	V	V
PDGFD	V	V		V
F2R	V	V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
MYH9	V				V		V
CXCR4	V				V		V
KNG1	V	V		V
MAPK1								V
CRK								V
EGFR								V
+ 5. Organismal Systems	17.2	15.1	11.8	11.1	13.5	6.2	12.6	19.4	4.1	4.1
+ 5.1 Immune system	14.9	13.4	10.2	9.2	7.9	2.7	8.1	22.2	1.3	1.4
+ 04640: Hematopoietic cell lineage	5.7	5.3	4	3.4	2.6	0	3	5.4	0	0
ITGA6	V	V		V
ITGA4	V	V		V
GP1BA	V	V	V
ITGA2B	V	V	V
CD9	V	V	V
CD44	V				V		V
IL1R1	V	V	V
IL1R2	V	V	V
ITGAM	V	V	V
ANPEP	V	V	V					V
CD37	V				V		V
CR2	V	V		V
MS4A1	V	V		V
CD24	V	V	V
CD3D	V				V		V
CD3E	V	V		V	V		V
CD3G	V	V		V
CD8A	V	V		V
CD8B	V	V		V
CD4	V	V		V
CD5	V	V		V
CD7	V	V		V
IL7R	V	V		V	V		V
HLA-DMB	V				V		V
HLA-DOB	V	V		V
HLA-DPA1	V				V		V
HLA-DPB1	V				V		V
HLA-DQA2	V				V		V
TNF	V	V	V					V
CSF1	V	V	V
CSF2	V	V	V
IL1B	V				V		V
CD14								V
CR1								V
FCER2								V
HLA-DRB1								V
THPO								V
IL6								V
+ 04610: Complement and coagulation cascades	1.8	2.1	3.1	0.3	0.4	2.3	0	3.3	1.7	1.7
F2R	V	V		V
KNG1	V	V		V
C1S	V	V	V
SERPINA1	V	V	V
C4A	V				V	V
C4B	V				V	V
C4B_2	V				V	V
F5	V	V	V
CLU	V	V	V
CR2	V	V		V
ITGAM	V	V	V
VSIG4	V	V	V
C5AR1	V	V	V
C3AR1	V	V	V
MBL2								V
MASP2								V
VTN								V	V	V
CR1								V
F10									V
F3										V
+ 04611: Platelet activation	2.3	2.2	3	0.6	1.3	0	1.7	1.4	0.6	0.6
ITPR1	V	V		V
F2R	V	V		V
RASGRP1	V	V		V
RASGRP2	V				V		V
TLN1	V				V		V
ITGA2B	V	V	V
PIK3CB	V	V	V
AKT2	V				V		V
MAPK14	V	V	V					V
GNA13	V	V		V
RHOA	V				V		V
MYLK	V	V	V
ADCY7	V				V		V
PIK3R5	V	V		V	V		V
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
COL1A1	V	V	V
GP1BA	V	V	V
LYN	V	V	V
MAPK1								V
+ 04620: Toll-like receptor signaling pathway	1.5	1.6	2.2	0.6	0.4	0.6	0.3	7.6	0.7	0
IRAK1	V	V	V
RIPK1	V	V		V
IFNA21	V	V		V
MAP3K7	V	V		V
MAPK14	V	V	V					V
IL1B	V				V		V
AKT2	V				V		V
STAT1	V	V		V
NFKBIA	V	V	V
TNF	V	V	V					V
TLR2	V	V	V
CASP8	V	V		V
PIK3CB	V	V	V
IFNAR2	V	V	V
MAP2K4	V				V		V
MAP2K1	V				V	V
IFNB1								V
MAPK1								V
MAP3K8								V
CXCL10								V
IFNA1								V
IFNA13								V
CXCL8								V
IL6								V
CCL5								V
IRF3								V
CD14								V
MAP2K6									V
+ 04621: NOD-like receptor signaling pathway	4.5	4.2	3.2	2.8	1.7	0.9	1.6	8.6	0	0.4
MAP3K7	V	V		V
IL1B	V				V		V
CARD8	V				V		V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
MAPK14	V	V	V					V
TRPV2	V				V		V
ITPR1	V	V		V
JAK1	V				V		V
STAT1	V	V		V
STAT2	V	V		V
GSDMD	V				V	V
IFNAR2	V	V	V
RHOA	V				V		V
IFNA21	V	V		V
VDAC1	V	V		V
VDAC2	V				V		V
NFKBIA	V	V	V
TXNIP	V				V		V
BIRC3	V	V		V
XIAP	V	V		V
TXN	V	V	V
GABARAPL2	V				V		V
ATG12	V	V		V
ATG5	V	V		V
NAMPT	V	V	V		V		V
TRAF5	V	V		V
CASP8	V	V		V
BCL2	V	V		V
RIPK1	V	V		V
OAS2	V	V		V
RNASEL	V	V		V				V
TNF	V	V	V					V
CXCL1	V	V	V					V
CXCL2	V	V	V
CCL2	V				V	V		V
CAMP	V	V	V
DEFA1	V	V	V
DEFA1B	V	V	V
DEFA3	V	V	V
DEFA4	V	V	V
CASP1								V
NLRP3								V
MAPK1								V
IRF3								V
IFNA1								V
IFNA13								V
IFNB1								V
BCL2L1								V
RIPK3								V
OAS1								V
IL6								V
CXCL8								V
CCL5								V
CYBA										V
+ 04622: RIG-I-like receptor signaling pathway	1.4	1.7	1	1.5	0.2	0.8	0.1	7.4	0	0
CASP8	V	V		V
IFNA21	V	V		V
NFKBIA	V	V	V
ATG5	V	V		V
ATG12	V	V		V
CYLD	V				V		V
PIN1	V				V	V
RIPK1	V	V		V
MAPK14	V	V	V					V
MAP3K7	V	V		V
TNF	V	V	V					V
IFIH1								V
TRIM25								V
IRF3								V
IFNA1								V
IFNA13								V
IFNB1								V
ISG15								V
CXCL8								V
CXCL10								V
+ 04623: Cytosolic DNA-sensing pathway	0.2	0.2	0.2	0.2	0.3	0	0.4	6.5	0	1
IL1B	V				V		V
IFNA21	V	V		V
RIPK1	V	V		V
NFKBIA	V	V	V
POLR2F	V				V		V			V
CASP1								V
IRF3								V
IFNB1								V
IFNA1								V
IFNA13								V
CXCL10								V
RIPK3								V
IL6								V
CCL5								V
+ 04625: C-type lectin receptor signaling pathway	3.2	3.1	2.2	2.2	2	0	2.5	6.3	0	0
CLEC4E	V	V	V
LSP1	V				V		V
PAK1	V				V		V
PTPN11	V	V		V
IL1B	V				V		V
CASP8	V	V		V
RHOA	V				V		V
CYLD	V				V		V
STAT1	V	V		V
STAT2	V	V		V
BCL3	V	V	V
NFKBIA	V	V	V
MALT1	V	V		V
ITPR1	V	V		V
TNF	V	V	V					V
CBLB	V	V		V
CLEC1B	V	V	V
PIK3CB	V	V	V
AKT2	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
MAPK14	V	V	V					V
CLEC4M								V
CD209								V
NLRP3								V
CASP1								V
IL6								V
IL10								V
MAPK1								V
IL2								V
+ 04650: Natural killer cell mediated cytotoxicity	3.4	4.1	2.2	3.5	0.7	1.1	0.4	6.4	0	0
PLCG1	V	V		V
CSF2	V	V	V
TNF	V	V	V					V
PRKCA	V	V		V				V
SH3BP2	V	V	V
LCK	V	V		V
SH2D1A	V	V		V
CD247	V	V		V
PTPN11	V	V		V
PTPN6	V	V	V		V		V
IFNA21	V	V		V
HLA-B	V				V		V	V
PIK3CB	V	V	V
MAP2K1	V				V	V
SHC3	V	V	V
PAK1	V				V		V
VAV1	V				V		V
FASLG	V	V		V
KLRD1	V	V		V
IFNAR2	V	V	V
KLRC4-KLRK1	V	V		V
KLRK1	V	V		V
NCR3	V	V		V
FCGR3B	V	V	V		V	V
KLRC2	V	V		V
KLRC3	V	V		V
KIR2DS5	V	V		V
KLRC1	V	V		V
IFNG								V
PRKCB								V
IFNA1								V
IFNA13								V
IFNB1								V
CASP3								V
HLA-A								V
MAPK1								V
+ 04612: Antigen processing and presentation	6.5	4.6	0.1	5.6	4.2	0	4.6	6.2	0.9	0.9
CD74	V				V		V
HLA-DMB	V				V		V
NFYA	V	V		V
NFYB	V	V		V
RFX5	V	V		V
CTSS	V				V		V
CD4	V	V		V
KIR2DS5	V	V		V
KLRC1	V	V		V
KLRC2	V	V		V
KLRC3	V	V		V
KLRD1	V	V		V
KLRC4	V	V		V
CD8A	V	V		V
CD8B	V	V		V
PDIA3	V	V		V
B2M	V				V		V	V
HLA-B	V				V		V	V
HLA-F	V	V		V
HLA-DOB	V	V		V
HLA-DPA1	V				V		V
HLA-DPB1	V				V		V
HLA-DQA2	V				V		V
CANX	V	V		V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
HSPA1A	V				V		V
HSPA1B	V				V		V
HSPA8	V	V		V	V		V
PSME1	V				V		V
TNF	V	V	V					V
CREB1								V
CTSL								V	V	V
CALR								V
HLA-A								V
HLA-DRB1								V
IFNG								V
+ 04660: T cell receptor signaling pathway	5.7	5.1	2.3	4.5	2.8	0.6	2.9	5.3	0	0
TNF	V	V	V					V
CSF2	V	V	V
NFKBIA	V	V	V
AKT2	V				V		V
MALT1	V	V		V
PRKCQ	V	V		V
PIK3CB	V	V	V
CD28	V	V		V
CD40LG	V	V		V
RASGRP1	V	V		V
ITK	V	V		V
PLCG1	V	V		V
VAV1	V				V		V
RHOA	V				V		V
BUB1B-PAK6	V				V		V
PAK6	V				V		V
PAK1	V				V		V
NCK1	V	V		V
CD3E	V	V		V	V		V
CD3D	V				V		V
CD247	V	V		V
CD3G	V	V		V
CD4	V	V		V
CD8A	V	V		V
CD8B	V	V		V
CBLB	V	V		V
LCK	V	V		V
PTPRC	V				V		V
PTPN6	V	V	V		V		V
MAP2K1	V				V	V
MAP3K7	V	V		V
MAPK14	V	V	V					V
GSK3B	V	V	V
IFNG								V
IL10								V
IL2								V
MAP3K8								V
GRAP2								V
MAPK1								V
+ 04658: Th1 and Th2 cell differentiation	4.2	3.5	0.7	3.8	3	0	3.5	4.3	0	0
NFKBIA	V	V	V
PRKCQ	V	V		V
CD3E	V	V		V	V		V
CD3D	V				V		V
CD247	V	V		V
CD3G	V	V		V
MAPK14	V	V	V					V
PLCG1	V	V		V
CD4	V	V		V
LCK	V	V		V
STAT1	V	V		V
STAT4	V	V		V
STAT6	V				V		V
GATA3	V	V		V
TBX21	V	V		V
IL2RB	V	V		V
NOTCH1	V				V		V
NOTCH3	V	V	V		V		V
HLA-DMB	V				V		V
HLA-DOB	V	V		V
HLA-DPA1	V				V		V
HLA-DPB1	V				V		V
HLA-DQA2	V				V		V
JAK1	V				V		V
RUNX3	V	V		V	V		V
IFNG								V
MAPK1								V
IL12RB1								V
IL2								V
HLA-DRB1								V
+ 04659: Th17 cell differentiation	4.7	4.1	0.6	4.6	2.3	0	2.8	4.7	0	0
NFKBIA	V	V	V
PRKCQ	V	V		V
MAPK14	V	V	V					V
PLCG1	V	V		V
CD4	V	V		V
LCK	V	V		V
STAT1	V	V		V
STAT6	V				V		V
IL2RB	V	V		V
HLA-DMB	V				V		V
HLA-DOB	V	V		V
HLA-DPA1	V				V		V
HLA-DPB1	V				V		V
HLA-DQA2	V				V		V
IL1R1	V	V	V
IL21R	V	V		V
IL6ST	V	V		V
TGFBR2	V	V		V
TBX21	V	V		V
GATA3	V	V		V
SMAD3	V	V		V
SMAD4	V	V		V
IL1B	V				V		V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
CD3E	V	V		V	V		V
CD3G	V	V		V
CD3D	V				V		V
CD247	V	V		V
JAK1	V				V		V
MAPK1								V
IFNG								V
IL2								V
HLA-DRB1								V
IL12RB1								V
IL6								V
+ 04657: IL-17 signaling pathway	3.2	3.4	4	1.1	0.9	0.7	0.8	6.9	0	0
MAP3K7	V	V		V
NFKBIA	V	V	V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
HSP90B1	V				V		V
TRAF5	V	V		V
SRSF1	V	V		V
MAPK14	V	V	V					V
CASP8	V	V		V
GSK3B	V	V	V
CXCL1	V	V	V					V
CXCL2	V	V	V
CCL2	V				V	V		V
MMP9	V	V	V
ANAPC5	V	V		V
CSF2	V	V	V
LCN2	V	V	V
TNF	V	V	V					V
S100A8	V	V	V		V		V
S100A9	V	V	V
IL1B	V				V		V
IL6								V
MAPK1								V
CASP3								V
CXCL8								V
CXCL6								V
CXCL10								V
IFNG								V
+ 04662: B cell receptor signaling pathway	2.6	2.7	2.7	1.3	1.1	0.7	1	1.8	0	0
NFKBIA	V	V	V
GSK3B	V	V	V
MALT1	V	V		V
AKT2	V				V		V
VAV1	V				V		V
PIK3CB	V	V	V
CR2	V	V		V
CD81	V	V		V
BLNK	V	V		V
LYN	V	V	V
CD79A	V	V		V
PTPN6	V	V	V		V		V
CD72	V	V		V
LILRA3	V	V	V
LILRA2	V	V	V
MAP2K1	V				V	V
PIK3AP1	V				V		V
PRKCB								V
MAPK1								V
+ 04664: Fc epsilon RI signaling pathway	2.1	1.8	3	0.2	1.8	0.8	1.7	3.4	1	0
TNF	V	V	V					V
AKT2	V				V		V
CSF2	V	V	V
MAPK14	V	V	V					V
MAP2K4	V				V		V
PIK3CB	V	V	V
PRKCA	V	V		V				V
GAB2	V	V	V		V		V
LYN	V	V	V
PLCG1	V	V		V
MAP2K1	V				V	V
VAV1	V				V		V
ALOX5	V	V	V		V		V
MAPK1								V
MAP2K6									V
+ 04666: Fc gamma R-mediated phagocytosis	3.2	1.7	2.4	0.4	3.7	2.1	3.1	3.1	0	0
FCGR3B	V	V	V		V	V
LYN	V	V	V
PTPRC	V				V		V
PIK3CB	V	V	V
PLCG1	V	V		V
MAP2K1	V				V	V
AKT2	V				V		V
VAV1	V				V		V
ARPC5	V				V		V
DOCK2	V				V		V
PAK1	V				V		V
CFL1	V	V	V
MARCKS	V				V	V
MARCKSL1	V	V		V
GSN	V	V	V		V		V
PIP5K1B	V				V		V
PLPP1	V	V		V
GAB2	V	V	V		V		V
NCF1	V	V	V
AMPH	V				V		V
PRKCA	V	V		V				V
MAPK1								V
CRK								V
PRKCB								V
+ 04670: Leukocyte transendothelial migration	4.3	3.9	4.3	1.4	1.5	0.6	1.6	2.2	0.7	1.4
CLDN17	V	V	V
CLDN5	V	V	V
CLDN1	V				V	V
MMP9	V	V	V
PTPN11	V	V		V
CD99	V				V		V
SIPA1	V				V		V
ITGA4	V	V		V
ITGAM	V	V	V
PIK3CB	V	V	V
ACTB	V	V	V						V	V
ACTG1	V	V	V
MYL9	V	V	V
MYLPF	V	V	V
PRKCA	V	V		V				V
RHOA	V				V		V
MAPK14	V	V	V					V
ARHGAP5	V	V		V
NCF2	V				V		V
NCF1	V	V	V
NCF4	V	V	V
VAV1	V				V		V
EZR	V				V		V
ITK	V	V		V
TXK	V	V		V
CXCR4	V				V		V
PLCG1	V	V		V
RHOH	V	V		V
ACTN1	V	V	V
PRKCB								V
CYBA										V
+ 04672: Intestinal immune network for IgA production	1.7	0.7	0	1.3	1.9	0	2.2	3.8	0	0
CD40LG	V	V		V
CD28	V	V		V
HLA-DMB	V				V		V
HLA-DOB	V	V		V
HLA-DPA1	V				V		V
HLA-DPB1	V				V		V
HLA-DQA2	V				V		V
ITGA4	V	V		V
CXCR4	V				V		V
IL6								V
HLA-DRB1								V
IL10								V
IL2								V
+ 04062: Chemokine signaling pathway	4.5	3.9	3.9	1.8	2.6	0.8	2.6	4.8	0	0
CCR6	V	V		V
CCR7	V	V		V
CXCR1	V	V	V
CXCR2	V	V	V
CXCR5	V	V		V
CCR2	V				V		V
CXCR4	V				V		V
CXCL1	V	V	V					V
CXCL2	V	V	V
PPBP	V	V	V
CCL2	V				V	V		V
CCL8	V	V		V
CCL19	V				V		V
XCL1	V	V		V
XCL2	V	V		V
LYN	V	V	V
RHOA	V				V		V
PIK3CB	V	V	V
SHC3	V	V	V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
GRK4	V	V	V
GRK6	V	V	V
ARRB1	V	V		V
VAV1	V				V		V
ITK	V	V		V
ADCY7	V				V		V
RASGRP2	V				V		V
TIAM1	V	V		V	V		V
NCF1	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
PAK1	V				V		V
STAT1	V	V		V
STAT2	V	V		V
AKT2	V				V		V
MAP2K1	V				V	V
DOCK2	V				V		V
NFKBIA	V	V	V
FOXO3	V	V	V
GSK3B	V	V	V
PIK3R5	V	V		V	V		V
CXCL8								V
CXCL10								V
CCL5								V
CXCL6								V
CRK								V
PRKCB								V
MAPK1								V
+ 5.2 Endocrine system	9	8.2	7	5.7	7.8	4.5	6.9	12.1	3.8	3
+ 04911: Insulin secretion	0.9	0.7	1.2	0.3	1	0.7	0.9	3.2	0.8	0
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
GCK	V	V	V
PRKCA	V	V		V				V
RYR2	V	V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
CAMK2D	V				V		V
PRKCB								V
CREB1								V
CCK									V
+ 04910: Insulin signaling pathway	2.3	1.9	1.7	1.2	2	1.7	1.5	2	1.3	1.3
INPP5K	V				V		V
SOCS3	V				V	V		V
PRKAB1	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
PRKACA	V				V		V
PRKACB	V	V		V
RPS6	V				V		V
PYGL	V	V	V
FOXO1	V	V		V
MAP2K1	V				V	V
SHC3	V	V	V
INSR	V	V	V
TSC2	V				V	V
PDE3B	V	V		V
AKT2	V				V		V
PIK3CB	V	V	V
GSK3B	V	V	V
SREBF1	V	V		V
GCK	V	V	V
HK1	V				V		V		V	V
CBLB	V	V		V
IRS2	V	V	V
MAPK1								V
CRK								V
HKDC1									V	V
+ 04922: Glucagon signaling pathway	2.8	2.8	1	2.9	2.1	1.3	1.7	1.6	0	0
GCK	V	V	V
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
PYGL	V	V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
PPP4R3B	V				V	V
EP300	V	V		V
FOXO1	V	V		V
AKT2	V				V		V
PDE3B	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
PRKAB1	V	V		V
CAMK2D	V				V		V
ITPR1	V	V		V
LDHB	V	V		V
SIRT1	V	V		V
CREB1								V
+ 04923: Regulation of lipolysis in adipocytes	1.7	1.5	1.8	0.7	1.2	0	1.5	0	0	0
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
ADRB2	V	V		V
INSR	V	V	V
PDE3B	V	V		V
PIK3CB	V	V	V
IRS2	V	V	V
AKT2	V				V		V
+ 04920: Adipocytokine signaling pathway	1.7	1.4	2	0.4	1.3	0.8	1.2	1.9	0	0
NFKBIA	V	V	V
PTPN11	V	V		V
SOCS3	V				V	V		V
ACSL1	V	V	V
ACSL6	V				V		V
PRKAB1	V	V		V
PRKCQ	V	V		V
CAMKK2	V	V	V		V		V
TNFRSF1B	V				V		V
AKT2	V				V		V
IRS2	V	V	V
TNF	V	V	V					V
+ 03320: PPAR signaling pathway	0.9	1.6	1.4	1	0	0	0.1	0	3.3	1.8
SCP2	V	V		V
ACADM	V	V		V
ACSL1	V	V	V
ACSL6	V				V		V
OLR1	V	V	V
CYP7A1	V	V		V
HMGCS1	V	V		V
SCD	V	V	V						V
NR1H3	V	V		V
CYP27A1	V	V	V
APOA2									V	V
APOA1									V	V
DBI									V
+ 04912: GnRH signaling pathway	2.1	1.7	1.1	1.4	2.7	0.7	2.7	3.7	0.8	0
PRKCA	V	V		V				V
ADCY7	V				V		V
ATF4	V	V	V
CAMK2D	V				V		V
MAPK14	V	V	V					V
MAP3K3	V				V		V
MAP3K4	V	V		V
ITPR1	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
MAP2K1	V				V	V
MAP2K4	V				V		V
EGR1	V	V	V
PRKCB								V
MAPK1								V
EGFR								V
MAP2K6									V
+ 04913: Ovarian steroidogenesis	1.6	1	1.4	0.4	2.3	1	2.1	0	0	0
AKR1C3	V	V		V
GNAS	V	V	V		V		V
ADCY7	V				V		V
CYP19A1	V				V	V
PRKACA	V				V		V
PRKACB	V	V		V
INSR	V	V	V
IGF1R	V				V		V
ALOX5	V	V	V		V		V
+ 04915: Estrogen signaling pathway	3.1	2.1	1.7	1.5	3.5	1.7	3.1	3.8	2.6	1.9
GPER1	V	V	V					V
MMP9	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
MAP2K1	V				V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
ADCY7	V				V		V
PIK3CB	V	V	V
AKT2	V				V		V
SHC3	V	V	V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
HSP90B1	V				V		V
FKBP5	V	V		V
HSPA1A	V				V		V
HSPA1B	V				V		V
HSPA8	V	V		V	V		V
GNAS	V	V	V		V		V
ITPR1	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
NCOA1	V				V		V
BCL2	V	V		V
KRT13	V				V	V
KRT32	V	V	V
ESR1								V
EGFR								V
MAPK1								V
CREB1								V
KRT14									V	V
KRT16									V
KRT17									V	V
KRT20									V
SP1										V
+ 04914: Progesterone-mediated oocyte maturation	2.8	1.9	1.5	1.4	2.6	2.8	1.5	1.6	0.8	0.8
IGF1R	V				V		V
ADCY7	V				V		V
CDK1	V	V	V
PIK3CB	V	V	V
AKT2	V				V		V
PDE3B	V	V		V
ANAPC5	V	V		V
CDC23	V	V		V
CDC16	V	V		V
CDC27	V	V		V	V	V
MAD1L1	V				V	V
CDC25A	V	V	V		V	V
CCNB2	V	V	V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
PRKACA	V				V		V
PRKACB	V	V		V
RPS6KA1	V				V		V
MAP2K1	V				V	V
MAPK14	V	V	V					V
MAPK1								V
AURKA									V	V
+ 04917: Prolactin signaling pathway	1.7	1.7	2.5	0.4	0.5	1.7	0.1	3.4	0	0
AKT2	V				V		V
PIK3CB	V	V	V
MAP2K1	V				V	V
STAT1	V	V		V
SHC3	V	V	V
FOXO3	V	V	V
MAPK14	V	V	V					V
SOCS3	V				V	V		V
TH	V	V		V
GCK	V	V	V
CCND2	V	V		V
GSK3B	V	V	V
MAPK1								V
ESR1								V
+ 04921: Oxytocin signaling pathway	2	2.3	2.2	1.3	2.1	1	1.9	2.5	0.5	0.5
MYLK	V	V	V
ITPR1	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
PRKCA	V	V		V				V
MAP2K1	V				V	V
CAMK4	V	V		V
CAMK2D	V				V		V
MYL9	V	V	V
MYL6B	V	V	V
MYL6	V	V	V
ACTB	V	V	V						V	V
ACTG1	V	V	V
RHOA	V				V		V
CACNA2D3	V	V		V
CACNB3	V				V	V
CAMKK2	V	V	V		V		V
PRKAB1	V	V		V
RYR2	V	V	V
PIK3R5	V	V		V	V		V
PRKCB								V
MAPK1								V
EGFR								V
+ 04926: Relaxin signaling pathway	2.7	2.8	3.6	0.8	1.2	1.1	1	3.9	0	0
AKT2	V				V		V
NFKBIA	V	V	V
PIK3CB	V	V	V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
VEGFC	V	V	V
MMP9	V	V	V
SMAD3	V	V		V
COL1A1	V	V	V
ADCY7	V				V		V
MAP2K1	V				V	V
PRKCA	V	V		V				V
SHC3	V	V	V
GNA15	V	V	V
TGFBR2	V	V		V
MAP2K4	V				V		V
MAPK14	V	V	V					V
ARRB1	V	V		V
MAPK1								V
CREB1								V
EGFR								V
+ 04918: Thyroid hormone synthesis	2.1	1	0.5	1.1	2.4	0.8	2.4	4	2.6	0.9
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKCA	V	V		V				V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
ITPR1	V	V		V
HSP90B1	V				V		V
CANX	V	V		V
GPX3	V				V		V
ALB	V				V		V		V	V
SERPINA7	V				V		V
TPO								V
PRKCB								V
CREB1								V
ASGR1									V
TTR									V
+ 04919: Thyroid hormone signaling pathway	3.6	3.2	1.6	2.8	1.7	1.9	1.1	2.8	0.6	0.6
AKT2	V				V		V
PIK3CB	V	V	V
PRKCA	V	V		V				V
GSK3B	V	V	V
PLCG1	V	V		V
MAP2K1	V				V	V
STAT1	V	V		V
PLN	V				V	V
PRKACA	V				V		V
PRKACB	V	V		V
TP53	V	V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
HDAC1	V	V		V
HDAC2	V	V		V
KAT2A	V	V		V
NCOA1	V				V		V
EP300	V	V		V
MED16	V	V	V
MED14	V	V		V
MED17	V	V		V
MED1	V				V		V
TSC2	V				V	V
FOXO1	V	V		V
NOTCH1	V				V		V
NOTCH3	V	V	V		V		V
MYC	V	V		V
PRKCB								V
MAPK1								V
ESR1								V
+ 04928: Parathyroid hormone synthesis, secretion and action	2.6	2.5	1.8	1.8	1.7	1.3	1.3	4.2	0	0.7
ITPR1	V	V		V
ADCY7	V				V		V
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
PDE4B	V	V		V
GATA3	V	V		V
ARRB1	V	V		V
MAP2K1	V				V	V
PRKCA	V	V		V				V
GNA13	V	V		V
RHOA	V				V		V
SLC9A3R1	V				V		V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
BCL2	V	V		V
NACA	V				V		V
MEF2D	V	V	V
KL	V	V	V
EGR1	V	V	V
MMP25		V	V
MAPK1								V
PRKCB								V
EGFR								V
CREB1								V
SP1										V
+ 04916: Melanogenesis	1.6	1.7	1	1.6	1.8	0.6	1.8	3	0	0
PRKACA	V				V		V
PRKACB	V	V		V
CAMK2D	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
EP300	V	V		V
LEF1	V	V		V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKCA	V	V		V				V
GSK3B	V	V	V
MC1R	V	V		V
WNT1	V	V	V
WNT8B	V	V	V
MAP2K1	V				V	V
PRKCB								V
CREB1								V
MAPK1								V
+ 04924: Renin secretion	0.9	1.4	0.2	2	1.3	0	1.6	2.7	0.9	0.9
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
ADRB2	V	V		V
ITPR1	V	V		V
PDE3B	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
CREB1								V
AGT								V	V	V
ACE								V
+ 04614: Renin-angiotensin system	1.6	1.7	2.9	0	1.1	0	1.3	4.5	1.5	1.5
AGTR2	V	V	V
ANPEP	V	V	V					V
CTSA	V	V	V
CTSG	V	V	V		V		V
ATP6AP2	V				V		V
ACE2								V
ACE								V
AGT								V	V	V
+ 04925: Aldosterone synthesis and secretion	1.9	2.1	0.3	2.7	2.2	0.6	2.2	3.7	0.8	0.8
ITPR1	V	V		V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
ADCY7	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
GNAS	V	V	V		V		V
PRKCA	V	V		V				V
PRKD3	V	V		V
CAMK4	V	V		V
CAMK2D	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
ATP2B1	V	V		V
ATP2B4	V	V		V	V		V
CREB1								V
PRKCB								V
AGT								V	V	V
+ 04927: Cortisol synthesis and secretion	0.7	0.6	0.6	0.5	1	0.9	0.8	2.7	1	1.9
ITPR1	V	V		V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
ADCY7	V				V		V
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
CREB1								V
AGT								V	V	V
SP1										V
+ 5.3 Circulatory system	3.3	3.1	2.2	2.6	4.1	1.6	3.9	3.7	1.1	1.1
+ 04260: Cardiac muscle contraction	0.4	0.3	0.8	0.1	1.3	0.7	1.3	0	0	0
CACNA2D3	V	V		V
CACNB3	V				V	V
RYR2	V	V	V
TPM1	V	V	V		V		V
TPM2	V	V		V
TPM4	V				V		V
COX4I1	V				V		V
COX6A1	V	V	V		V		V
COX7C	V				V		V
+ 04261: Adrenergic signaling in cardiomyocytes	3.4	2.8	1.2	2.8	3.9	1.6	3.5	3.7	0.5	0.5
CACNA2D3	V	V		V
CACNB3	V				V	V
RYR2	V	V	V
TPM1	V	V	V		V		V
TPM2	V	V		V
TPM4	V				V		V
ADRB2	V	V		V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
PIK3R5	V	V		V	V		V
AKT2	V				V		V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
PLN	V				V	V
PPP2R1A	V				V		V
PPP2R5C	V	V		V	V		V
PPP2R5D	V				V		V
PPP2R5E	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
CAMK2D	V				V		V
AGTR2	V	V	V
PRKCA	V	V		V				V
MAPK14	V	V	V					V
BCL2	V	V		V
ATP2B1	V	V		V
ATP2B4	V	V		V	V		V
MAPK1								V
CREB1								V
AGT								V	V	V
+ 04270: Vascular smooth muscle contraction	1.8	2.3	1.8	1.6	1.8	0.5	1.9	2.7	1.3	1.3
MYLK	V	V	V
MYL9	V	V	V
MYL6B	V	V	V
MYL6	V	V	V
PRKCA	V	V		V				V
PRKCH	V	V		V
PRKCQ	V	V		V
RHOA	V				V		V
GNA13	V	V		V
ITPR1	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
MAP2K1	V				V	V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
MYH11	V	V		V	V		V
NPPC	V	V	V
ADM	V	V	V		V		V
PRKCB								V
MAPK1								V
AGT								V	V	V
PLA2G2A									V	V
+ 5.4 Digestive system	3.5	2.5	2.1	2.2	4.1	3.1	3.1	2.8	3.9	3.7
+ 04970: Salivary secretion	1.5	2.1	0.8	2.2	1.7	0	2	1.7	0	0
ADRB2	V	V		V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
ITPR1	V	V		V
ATP2B1	V	V		V
ATP2B4	V	V		V	V		V
PRKCA	V	V		V				V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
HTN3	V	V	V
CAMP	V	V	V
PRKCB								V
+ 04971: Gastric acid secretion	2.9	2.6	1.4	2.2	2.8	0.8	2.7	1.8	0.9	0.9
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
ITPR1	V	V		V
PRKCA	V	V		V				V
GNAS	V	V	V		V		V
EZR	V				V		V
CA2	V				V	V
KCNJ1	V	V		V
KCNJ10	V	V		V
KCNJ15	V	V	V
ACTB	V	V	V						V	V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
MYLK	V	V	V
CAMK2D	V				V		V
PRKCB								V
+ 04972: Pancreatic secretion	0.6	0.3	0.3	0.4	1.5	0.6	1.5	2.4	1.6	0.8
ITPR1	V	V		V
ATP2B1	V	V		V
ATP2B4	V	V		V	V		V
PRKCA	V	V		V				V
CA2	V				V	V
RYR2	V	V	V
GNAS	V	V	V		V		V
ADCY7	V				V		V
RAB8A	V				V		V
RAB11A	V				V		V
RHOA	V				V		V
PRKCB								V
CTRL								V
PLA2G2A									V	V
CCK									V
+ 04976: Bile secretion	1.6	1	1	0.7	1.7	1.6	1.1	0	0	0
AQP9	V	V	V
CA2	V				V	V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
CYP7A1	V	V		V
SLC22A1	V	V	V
ABCB1	V	V		V
SLC5A1	V				V	V
BAAT	V				V		V
SLC4A5	V	V		V
+ 04973: Carbohydrate digestion and absorption	0.9	0.2	0.9	0	1.5	2	0.7	1.2	2.2	2.2
SLC5A1	V				V	V
SLC2A5	V				V	V
MGAM	V	V	V
HK1	V				V		V		V	V
PIK3CB	V	V	V
AKT2	V				V		V
PRKCB								V
HKDC1									V	V
+ 04974: Protein digestion and absorption	0	0	0.4	0	0	0	0	1.7	0	0
COL1A1	V	V	V
COL10A1	V	V	V
CTRL								V
ACE2								V
+ 04975: Fat digestion and absorption	0	0.1	0	0.2	0	0	0	0	2.3	2.3
PLPP1	V	V		V
PLA2G2A									V	V
APOA1									V	V
+ 04979: Cholesterol metabolism	1.7	1	0.9	0.8	1.4	0	1.7	0	3	3
SOAT1	V	V		V
LDLRAP1	V				V		V
LIPA	V				V		V
NPC2	V				V		V
VDAC1	V	V		V
VDAC2	V				V		V
CYP27A1	V	V	V
CYP7A1	V	V		V
LRPAP1	V	V	V
APOA1									V	V
APOE									V	V
APOA2									V	V
+ 04977: Vitamin digestion and absorption	0.1	0.2	0.7	0	0	0	0	0	1.5	1.5
SLC19A1	V	V	V
APOA1									V	V
+ 04978: Mineral absorption	1.8	0.3	0.3	0.3	2.6	4.7	0.2	0	1.1	1.1
ATP2B1	V	V		V
SLC11A2	V	V		V
FTL	V				V	V
SLC30A1	V				V		V
MT1B	V				V	V
MT1E	V				V	V
MT1G	V
MT2A	V				V	V
SLC26A6	V	V	V
SLC5A1	V				V	V
MT1M					V	V
TF									V	V
+ 5.5 Excretory system	3.3	2.4	2.2	1.7	2.8	2.6	2.1	3.3	0.6	1.2
+ 04962: Vasopressin-regulated water reabsorption	2.6	0.8	0.9	0.5	3.4	2	2.8	1.2	0	0
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
CREB5	V				V	V
ARHGDIB	V				V		V
RAB11A	V				V		V
NSF	V				V		V
DCTN2	V	V	V
DCTN4	V	V		V
DYNC1H1	V				V	V
DYNC1I2	V				V		V
CREB1								V
+ 04960: Aldosterone-regulated sodium reabsorption	1.5	1.5	1.1	1.1	0.7	1.2	0.3	3.2	0	1.3
SGK1	V				V		V
NR3C2	V	V		V
HSD11B2	V				V	V
INSR	V	V	V
PIK3CB	V	V	V
KCNJ1	V	V		V
PRKCA	V	V		V				V
MAPK1								V
PRKCB								V
NEDD4L										V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	1.3	1	0.8	0.8	1.3	0	1.6	3	0	0
ATP2B1	V	V		V
AP2B1	V				V		V
RAB11A	V				V		V
KL	V	V	V
PRKCA	V	V		V				V
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
PRKCB								V
ESR1								V
+ 04964: Proximal tubule bicarbonate reclamation	1.1	1.1	0.7	1	0.5	1.4	0	0	0	0
CA4	V	V	V
CA2	V				V	V
GLUD2	V	V		V
MDH1	V	V		V
+ 04966: Collecting duct acid secretion	0.9	1	1.4	0.3	0.4	1.3	0	0	1.4	1.4
TCIRG1	V	V	V
SLC4A1	V	V	V
CA2	V				V	V
SLC12A7	V	V		V
ATP6V0A4									V	V
+ 5.6 Nervous system	5.1	4.9	4.7	3.3	4.7	1.9	4.7	7.4	0.5	0.7
+ 04724: Glutamatergic synapse	0.8	1.4	2.1	0.5	0.6	0	0.8	2.2	0	0
GRIA4	V	V		V
GRIN2D	V	V	V
SLC1A3	V	V	V
ADCY7	V				V		V
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
ITPR1	V	V		V
PRKCA	V	V		V				V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
GLUL	V	V	V		V		V
HOMER2	V	V	V
PRKCB								V
MAPK1								V
+ 04727: GABAergic synapse	1.5	0.9	1.6	0.2	2	0.7	2	1.7	0	0
ADCY7	V				V		V
SLC6A1	V				V	V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
GABRB3	V	V	V
GABRE	V	V	V
GLUL	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
GABARAPL2	V				V		V
NSF	V				V		V
PLCL1	V				V		V
PRKCA	V	V		V				V
PRKCB								V
+ 04725: Cholinergic synapse	1.5	1.2	0.9	1	1.5	1.3	1.2	2.9	0	0
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
ITPR1	V	V		V
PRKCA	V	V		V				V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
ATF4	V	V	V
CREB5	V				V	V
CAMK4	V	V		V
CAMK2D	V				V		V
PIK3CB	V	V	V
AKT2	V				V		V
BCL2	V	V		V
PIK3R5	V	V		V	V		V
MAP2K1	V				V	V
PRKCB								V
MAPK1								V
CREB1								V
+ 04728: Dopaminergic synapse	3.4	3.3	1.4	3.1	2.8	0.5	2.9	3.3	0	0
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
ITPR1	V	V		V
PRKCA	V	V		V				V
DRD2	V	V		V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
AKT2	V				V		V
GSK3B	V	V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
MAPK14	V	V	V					V
TH	V	V		V
CAMK2D	V				V		V
PPP2R1A	V				V		V
PPP2R5C	V	V		V	V		V
PPP2R5D	V				V		V
PPP2R5E	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
KIF5C	V	V		V
CLOCK	V				V		V
ARNTL	V	V		V
GRIA4	V	V		V
PRKCB								V
CREB1								V
+ 04726: Serotonergic synapse	1.4	2.2	3.6	0.2	0.6	0.6	0.5	2.9	0.7	0.7
GNAS	V	V	V		V		V
PRKACA	V				V		V
PRKACB	V	V		V
ITPR1	V	V		V
PRKCA	V	V		V				V
SLC6A4	V	V	V
HTR1F	V	V	V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
CYP2C9	V	V	V
CYP2C18	V	V	V
ALOX12	V	V	V
ALOX5	V	V	V		V		V
ALOX12B	V	V	V
MAP2K1	V				V	V
GABRB3	V	V	V
PRKCB								V
CASP3								V
MAPK1								V
APP									V	V
+ 04720: Long-term potentiation	2.4	2.2	0.6	2.4	2.2	0.8	2.1	2.7	0	0
PRKCA	V	V		V				V
CAMK4	V	V		V
EP300	V	V		V
CAMK2D	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
RPS6KA1	V				V		V
ATF4	V	V	V
GRIN2D	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
MAP2K1	V				V	V
ITPR1	V	V		V
PRKCB								V
MAPK1								V
+ 04730: Long-term depression	1.1	0.7	0.7	0.6	1.5	0.9	1.3	2.8	0	0
GNA13	V	V		V
GNAS	V	V	V		V		V
GNAZ	V				V		V
PRKCA	V	V		V				V
IGF1R	V				V		V
MAP2K1	V				V	V
PPP2R1A	V				V		V
LYN	V	V	V
ITPR1	V	V		V
PRKCB								V
MAPK1								V
+ 04723: Retrograde endocannabinoid signaling	0.5	0.6	0.9	0.4	0.5	0	0.7	2.6	0	0.5
ITPR1	V	V		V
PRKCA	V	V		V				V
GABRB3	V	V	V
GABRE	V	V	V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
GRIA4	V	V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
MAPK14	V	V	V					V
NDUFA1	V				V		V
NDUFA5	V	V		V
NDUFA7	V				V		V
NDUFC2	V				V		V
PRKCB								V
MAPK1								V
NDUFA4										V
+ 04721: Synaptic vesicle cycle	0.3	0.1	0.9	0	0.7	0.8	0.6	0	0.9	0.9
NSF	V				V		V
AP2B1	V				V		V
TCIRG1	V	V	V
ATP6V0B	V				V		V
SLC1A3	V	V	V
SLC6A1	V				V	V
SLC6A4	V	V	V
ATP6V0A4									V	V
+ 04722: Neurotrophin signaling pathway	3.3	2.9	2.4	1.9	2.4	0.5	2.5	2.2	0	0
PIK3CB	V	V	V
PLCG1	V	V		V
SHC3	V	V	V
AKT2	V				V		V
MAP2K1	V				V	V
RPS6KA1	V				V		V
PTPN11	V	V		V
GSK3B	V	V	V
FOXO3	V	V	V
NFKBIA	V	V	V
ATF4	V	V	V
FASLG	V	V		V
CAMK4	V	V		V
CAMK2D	V				V		V
RHOA	V				V		V
TP53	V	V		V
MAPK14	V	V	V					V
MAP3K3	V				V		V
ARHGDIB	V				V		V
SH2B3	V	V		V
BEX3	V				V		V
IRAK1	V	V	V
BCL2	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
MAPK1								V
CRK								V
+ 5.7 Sensory system	1.8	2.1	0.8	2.2	2.2	0	2.5	1.2	0.4	0
+ 04744: Phototransduction	0.9	1.5	0	2.1	2.2	0	2.4	0	0	0
GNB1	V	V		V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
+ 04740: Olfactory transduction	0	0	0	0	0	0	0	0	0	0
GNB1	V	V		V	V		V
OR51E2	V	V		V
CAMK2D	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
PRKACA	V				V		V
PRKACB	V	V		V
ARRB1	V	V		V
+ 04742: Taste transduction	0	0	0.1	0	0	0	0.1	0	0	0
HTR1F	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
+ 04750: Inflammatory mediator regulation of TRP channels	2.6	2.6	1.5	2.3	2.1	0	2.5	2.3	0.7	0
IL1R1	V	V	V
IL1B	V				V		V
ALOX12	V	V	V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
CAMK2D	V				V		V
MAPK14	V	V	V					V
PLCG1	V	V		V
PIK3CB	V	V	V
ITPR1	V	V		V
TRPV2	V				V		V
PRKCA	V	V		V				V
PRKCH	V	V		V
PRKCQ	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
KNG1	V	V		V
PRKCB								V
MAP2K6									V
+ 5.8 Development and regeneration	4.1	3.3	3.7	1.4	2.5	1.9	2	3.9	0.7	1.2
+ 04360: Axon guidance	1.9	1	0.6	1.1	1.6	0.8	1.5	1.1	0.4	1
CXCR4	V				V		V
BUB1B-PAK6	V				V		V
PAK6	V				V		V
PAK1	V				V		V
RHOA	V				V		V
RASA1	V	V		V
NCK1	V	V		V
ROBO3	V	V		V
NGEF	V				V		V
EFNA1	V	V	V
NTN1	V	V		V
SEMA4D	V				V		V
NRP1	V	V		V
PTCH1	V	V		V
PRKCA	V	V		V				V
CAMK2D	V				V		V
RYK	V	V		V
PIK3CB	V	V	V
GSK3B	V	V	V
DPYSL5	V				V	V
CDK5	V				V		V
CFL1	V	V	V
SSH2	V				V		V
ENAH	V				V	V
PLCG1	V	V		V
PTPN11	V	V		V
ABLIM1	V	V		V
MYL9	V	V	V
MAPK1								V
SHH									V	V
EPHA2										V
+ 04380: Osteoclast differentiation	4	3.7	4.7	0.8	1.9	1.8	1.3	4.5	0.6	0.6
CSF1	V	V	V
CYLD	V				V		V
GAB2	V	V	V		V		V
NFKBIA	V	V	V
MAP3K7	V	V		V
MAP2K1	V				V	V
MAPK14	V	V	V					V
IFNAR2	V	V	V
JAK1	V				V		V
STAT1	V	V		V
STAT2	V	V		V
LCK	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
IL1B	V				V		V
IL1R1	V	V	V
FCGR3B	V	V	V		V	V
FCGR2C	V				V		V
BLNK	V	V		V
CAMK4	V	V		V
TNF	V	V	V					V
SOCS3	V				V	V		V
FHL2	V	V	V
TGFBR2	V	V		V
NCF2	V				V		V
NCF4	V	V	V
NCF1	V	V	V
LILRA3	V	V	V
LILRA2	V	V	V
SIRPA	V	V	V
IFNB1								V
IFNG								V
CREB1								V
MAPK1								V
MAP2K6									V
CYBA										V
+ 5.9 Aging	6.2	4.9	3	3.9	3.7	1	3.6	1.2	0	0
+ 04211: Longevity regulating pathway	4.3	3.9	2.5	2.9	2	1.5	1.6	1.7	0	0
FOXO1	V	V		V
FOXO3	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
IGF1R	V				V		V
IRS2	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
ADCY7	V				V		V
PRKAB1	V	V		V
INSR	V	V	V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
SOD2	V				V		V
TSC2	V				V	V
TP53	V	V		V
SESN1	V	V		V
SIRT1	V	V		V
KL	V	V	V
CAMKK2	V	V	V		V		V
CAMK4	V	V		V
ATG5	V	V		V
APPL1	V	V		V
EHMT2	V	V		V
CREB1								V
+ 04213: Longevity regulating pathway - multiple species	4.4	3.1	1.7	2.6	3.2	0	3.5	0	0	0
FOXO1	V	V		V
FOXO3	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
IGF1R	V				V		V
IRS2	V	V	V
INSR	V	V	V
PRKACA	V				V		V
PRKACB	V	V		V
ADCY7	V				V		V
PRKAB1	V	V		V
SOD2	V				V		V
SOD1	V				V		V
HSPA1A	V				V		V
HSPA1B	V				V		V
HSPA8	V	V		V	V		V
ATG5	V	V		V
SIRT1	V	V		V
HDAC1	V	V		V
HDAC2	V	V		V
+ 5.10 Environmental adaptation	3.1	2.8	1.3	2.9	2.8	0.4	3.1	3.4	0.8	0.8
+ 04710: Circadian rhythm	1.6	1.8	0	2.5	0.3	0	0.4	1.4	0	0
ARNTL	V	V		V
CLOCK	V				V		V
PER3	V	V		V
PER2	V	V		V
CRY1	V	V		V
PRKAB1	V	V		V
CREB1								V
+ 04713: Circadian entrainment	2.2	2.7	1.5	2.4	1.8	0	2.2	3.1	0	0
GRIN2D	V	V	V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
CAMK2D	V				V		V
PRKCA	V	V		V				V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
ITPR1	V	V		V
RYR2	V	V	V
GRIA4	V	V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
GNAS	V	V	V		V		V
PER3	V	V		V
PER2	V	V		V
PRKCB								V
MAPK1								V
CREB1								V
+ 04714: Thermogenesis	1.6	0.4	0.7	0.3	2.7	0.6	2.8	1.5	1.4	1.4
CREB5	V				V	V
PRKACA	V				V		V
PRKACB	V	V		V
MAPK14	V	V	V					V
GNAS	V	V	V		V		V
ATF2	V	V		V				V
ADCY7	V				V		V
ACTB	V	V	V						V	V
SMARCA2	V	V		V
SMARCC1	V	V		V
SMARCD3	V	V	V
SMARCE1	V	V		V
ACTG1	V	V	V
ZNF516	V				V		V
RPS6KA1	V				V		V
TSC2	V				V	V
RPS6	V				V		V
ACSL1	V	V	V
ACSL6	V				V		V
PRKAB1	V	V		V
COX4I1	V				V		V
COX6A1	V	V	V		V		V
COX7C	V				V		V
COX15	V				V		V
NDUFA1	V				V		V
NDUFA5	V	V		V
NDUFA7	V				V		V
NDUFC2	V				V		V
SDHD	V	V		V
ATP5F1C	V	V		V
ATP5PB	V				V		V
ATP5MC1	V				V		V
ATP5MC2	V				V		V
CREB1								V
COA4									V
ATP5PF									V	V
NDUFA4										V
+ 6. Human Diseases	15.4	14.3	12.1	9.2	7.7	5.5	6.5	16.5	2.5	2.7
+ 6.1 Cancer: overview	11.9	11.1	8.3	7.7	5.7	3.5	4.9	10.4	3.5	3
+ 05200: Pathways in cancer	5.5	5.3	2.3	4.9	2.9	0.6	3.1	6.1	0.8	1.6
WNT1	V	V	V
WNT8B	V	V	V
FN1	V				V	V		V
LAMA3	V				V	V			V	V
LAMA4	V				V		V
LAMB3	V	V	V
ITGA6	V	V		V
ITGA2B	V	V	V
APPL1	V	V		V
PIK3CB	V	V	V
JAK1	V				V		V
PDGFRB	V				V	V
IGF1R	V				V		V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
HSP90B1	V				V		V
GSK3B	V	V	V
AXIN1	V				V		V
CDKN1B	V	V		V
STAT1	V	V		V
MAP2K1	V				V	V
NFKBIA	V	V	V
CCDC6	V	V		V	V		V
NCOA4	V				V		V
PLCG1	V	V		V
RALA	V				V		V
RHOA	V				V		V
RALBP1	V				V		V
MYC	V	V		V
TP53	V	V		V
LEF1	V	V		V
PRKCA	V	V		V				V
PTCH1	V	V		V
EGLN1	V				V		V
EPAS1	V	V	V
EP300	V	V		V
RAD51	V	V	V
MLH1	V	V		V	V		V
MSH2	V	V		V
TGFB3	V				V		V
TGFBR2	V	V		V
SMAD3	V	V		V
SMAD4	V	V		V
MSH3	V	V		V
MSH6	V	V		V
HDAC1	V	V		V
HDAC2	V	V		V
GSTP1	V				V		V
RARB	V	V		V
JUP	V	V		V
CCND2	V	V		V
CASP8	V	V		V
BIRC5	V	V	V
BCL2	V	V		V
BIRC3	V	V		V
XIAP	V	V		V
TRAF1	V	V		V
TRAF5	V	V		V
VEGFC	V	V	V
ETS1	V	V		V
MMP9	V	V	V
FOXO1	V	V		V
AKT2	V				V		V
FASLG	V	V		V
LPAR6	V	V		V
F2R	V	V		V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
GNB1	V	V		V	V		V
GNG5	V	V	V
GNG10	V	V	V
GNA13	V	V		V
RASGRP1	V	V		V
RASGRP2	V				V		V
CXCR4	V				V		V
NOTCH1	V				V		V
NOTCH3	V	V	V		V		V
KEAP1	V	V		V
GSTO1	V	V	V
GADD45A	V	V	V
GADD45B	V	V	V
NCOA1	V				V		V
FRAT1	V	V	V
EML4	V	V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
CAMK2D	V				V		V
BCL2L11	V				V		V
PIM2	V				V		V
IFNA21	V	V		V
CSF2RB	V	V	V
IFNAR2	V	V	V
IL2RB	V	V		V
IL6ST	V	V		V
IL7R	V	V		V	V		V
IL13RA1	V	V	V
STAT2	V	V		V
STAT4	V	V		V
STAT6	V				V		V
KNG1	V	V		V
CASP3								V
CRK								V
EGFR								V
BCL2L1								V
PRKCB								V
RB1								V
CXCL8								V
IL6								V
MAPK1								V
ESR1								V
IFNA1								V
IFNA13								V
IFNG								V
IL2								V
IL12RB1								V
AGT								V	V	V
SHH									V	V
CEBPA									V	V
LAMC2										V
SP1										V
+ 05202: Transcriptional misregulation in cancer	7.1	7.8	6.3	4.7	1.3	0	1.8	2.9	3.8	1.6
FLI1	V	V		V	V		V
FEV	V	V		V
FOXO1	V	V		V
SS18	V	V		V
TFE3	V				V		V
MYC	V	V		V
ID2	V				V		V
ATM	V	V		V
IL2RB	V	V		V
TSPAN7	V	V		V
TGFBR2	V	V		V
ETV5	V	V		V
DDX5	V				V		V
MMP9	V	V	V
IL1R2	V	V	V
JUP	V	V		V
CEBPE	V	V	V
BCL2A1	V	V	V
PER2	V	V		V
ITGAM	V	V	V
BIRC3	V	V		V
TRAF1	V	V		V
PBX3	V	V		V
KDM6A	V	V		V
IGF1R	V				V		V
CDKN1B	V	V		V
CCND2	V	V		V
MYCN	V				V		V
TP53	V	V		V
COMMD3-BMI1	V	V		V	V		V
BMI1	V	V		V	V		V
CCNT2	V	V		V
CSF2	V	V	V
MPO	V	V	V
DEFA3	V	V	V
ELANE	V	V	V
DUSP6	V				V		V
CDKN2C	V	V	V
BCL11B	V	V		V
BCL6	V	V	V
H3F3A	V				V		V		V
H3F3B	V				V		V		V
HIST1H3A	V	V	V
HIST1H3D	V	V	V
HIST1H3C	V	V	V
HIST1H3E	V	V	V
HIST1H3I	V	V	V
HIST1H3G	V	V	V
HIST1H3J	V	V	V
HIST1H3H	V	V	V
HIST1H3B	V	V	V
HIST1H3F	V	V	V
HDAC1	V	V		V
HDAC2	V	V		V
LYL1	V	V	V
GADD45A	V	V	V
GADD45B	V	V	V
IL6								V
CXCL8								V
TMPRSS2								V
CD14								V
BCL2L1								V
CEBPA									V	V
HPGD									V	V
HIST2H3C									V
HIST2H3A									V
HIST2H3D									V
SP1										V
+ 05206: MicroRNAs in cancer	4.4	3.5	1.2	3.6	3.6	2.2	2.9	4.2	0	0
CDC25A	V	V	V		V	V
CDKN1B	V	V		V
PDCD4	V	V		V
EP300	V	V		V
TPM1	V	V	V		V		V
STMN1	V				V		V
MMP9	V	V	V
CCND2	V	V		V
EZR	V				V		V
BCL2	V	V		V
MYC	V	V		V
DNMT1	V	V		V
HNRNPK	V				V		V
IRS2	V	V	V
NOTCH1	V				V		V
NOTCH3	V	V	V		V		V
COMMD3-BMI1	V	V		V	V		V
BMI1	V	V		V	V		V
RECK	V	V		V
SIRT1	V	V		V
CD44	V				V		V
BCL2L11	V				V		V
MARCKS	V				V	V
HDAC1	V	V		V
UBE2I	V				V		V	V
ATM	V	V		V
TNC	V	V	V
TNXB	V				V		V
RHOA	V				V		V
ABCB1	V	V		V
PRKCA	V	V		V				V
TP53	V	V		V
MDM4	V	V		V
PLCG1	V	V		V
MAP2K1	V				V	V
PDGFRB	V				V	V
CRK								V
EGFR								V
CASP3								V
MAPK1								V
PRKCB								V
+ 05205: Proteoglycans in cancer	4	3	2.9	1.6	2.9	1.3	2.7	5.6	3.2	3.2
CD44	V				V		V
TIAM1	V	V		V	V		V
RHOA	V				V		V
ANK3	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
ITPR1	V	V		V
CAMK2D	V				V		V
FLNB	V	V		V
PAK1	V				V		V
ACTB	V	V	V						V	V
ACTG1	V	V	V
MAP2K1	V				V	V
DDX5	V				V		V
CTTN	V	V	V
VAV1	V				V		V
TP53	V	V		V
MMP9	V	V	V
PRKCA	V	V		V				V
TLR2	V	V	V
PDCD4	V	V		V
MYC	V	V		V
TNF	V	V	V					V
IGF1R	V				V		V
EIF4B	V	V		V
RPS6	V				V		V
FASLG	V	V		V
LUM	V	V	V
SDC1	V				V	V
WNT1	V	V	V
EZR	V				V		V
FN1	V				V	V		V
PTPN11	V	V		V
PLCG1	V	V		V
PTCH1	V	V		V
PRKACA	V				V		V
PRKACB	V	V		V
MAPK14	V	V	V					V
PTPN6	V	V	V		V		V
WNT8B	V	V	V
CD63	V	V	V		V		V
CAV2	V				V		V
MAPK1								V
ESR1								V
PRKCB								V
CTSL								V	V	V
VTN								V	V	V
EGFR								V
CASP3								V
SDC4									V	V
GPC3									V	V
SHH									V	V
+ 05204: Chemical carcinogenesis	0.2	0.3	1.3	0	0.1	0	0.2	0	0	0
ADH1B	V				V		V
ADH5	V	V		V
ADH6	V	V	V
GSTP1	V				V		V
GSTO1	V	V	V
CYP2C9	V	V	V
CYP2C18	V	V	V
+ 05203: Viral carcinogenesis	7.6	8.1	8	3.4	1.3	1.3	1	4.3	0	0
TP53	V	V		V
UBE3A	V	V		V
RBL2	V	V		V
TBP	V	V		V
CASP8	V	V		V
TRAF1	V	V		V
TRAF5	V	V		V
ATF2	V	V		V				V
ATF4	V	V	V
CREB5	V				V	V
JAK1	V				V		V
PIK3CB	V	V	V
POLB	V	V		V
MAD1L1	V				V	V
KAT2A	V	V		V
LYN	V	V	V
CCND2	V	V		V
YWHAQ	V				V		V
GTF2E1	V	V		V
SND1	V				V		V
EP300	V	V		V
GTF2B	V				V		V
DNAJA3	V	V		V
CDKN1B	V	V		V
HDAC1	V	V		V
HDAC2	V	V		V
RASA2	V	V		V	V	V
RHOA	V				V		V
GSN	V	V	V		V		V
ACTN1	V	V	V
NFKBIA	V	V	V
CDC20	V	V	V
IL6ST	V	V		V
HLA-B	V				V		V	V
HLA-F	V	V		V
HNRNPK	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
CDK1	V	V	V
HIST1H2BD	V	V	V
HIST1H2BG	V	V	V
HIST1H2BF	V	V	V
HIST1H2BE	V	V	V
HIST1H2BI	V	V	V
HIST1H2BC	V	V	V
HIST1H2BB	V	V	V
HIST1H2BH	V	V	V
HIST2H2BE	V	V	V
HIST1H2BK	V	V	V
HIST4H4	V	V	V
HIST2H4B	V	V	V
HIST1H4I	V	V	V
HIST1H4A	V	V	V
HIST1H4D	V	V	V
HIST1H4F	V	V	V
HIST1H4K	V	V	V
HIST1H4J	V	V	V
HIST1H4C	V	V	V
HIST1H4H	V	V	V
HIST1H4B	V	V	V
HIST1H4E	V	V	V
HIST1H4L	V	V	V
HIST2H4A	V	V	V
IRF3								V
RB1								V
CASP3								V
MAPK1								V
CREB1								V
HLA-A								V
+ 05230: Central carbon metabolism in cancer	1.4	0.5	0.6	0.4	1.7	2.4	0.7	1.9	1.8	1.8
GCK	V	V	V
MYC	V	V		V
LDHB	V	V		V
PDGFRB	V				V	V
MAP2K1	V				V	V
PIK3CB	V	V	V
AKT2	V				V		V
HK1	V				V		V		V	V
TP53	V	V		V
PFKM	V				V	V
G6PD	V				V		V
EGFR								V
MAPK1								V
HKDC1									V	V
+ 05231: Choline metabolism in cancer	1.7	1.2	0.6	1.3	1.1	2.1	0.4	3	0	0.7
MAP2K1	V				V	V
AKT2	V				V		V
PIK3CB	V	V	V
PDGFRB	V				V	V
PDGFC	V	V	V
PDGFD	V	V		V
SLC22A1	V	V	V
CHKB	V	V		V
PLCG1	V	V		V
TSC2	V				V	V
DGKA	V	V		V
DGKG	V	V		V
DGKD	V				V		V
PIP5K1B	V				V		V
PLPP1	V	V		V
PRKCA	V	V		V				V
MAPK1								V
EGFR								V
PRKCB								V
SP1										V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	3.8	3.5	1.6	3.2	2	0.7	2	3.1	0.8	0
NFKBIA	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
RASGRP1	V	V		V
PLCG1	V	V		V
CD3E	V	V		V	V		V
CD3D	V				V		V
CD247	V	V		V
CD3G	V	V		V
LCK	V	V		V
PTPN6	V	V	V		V		V
PTPN11	V	V		V
MAP2K1	V				V	V
JAK1	V				V		V
STAT1	V	V		V
TLR2	V	V	V
CD28	V	V		V
PRKCQ	V	V		V
MAP3K3	V				V		V
MAPK14	V	V	V					V
CSNK2B	V				V		V
EML4	V	V		V
CD4	V	V		V
MAPK1								V
EGFR								V
IFNG								V
MAP2K6									V
+ 6.2 Cancer: specific types	9.1	8.6	7.5	5.7	4.3	3.9	3.5	11.1	0.9	1.2
+ 05210: Colorectal cancer	4.2	3.7	1.7	3.3	2.1	0.7	2.1	2.5	0	0
TGFB3	V				V		V
PIK3CB	V	V	V
APPL1	V	V		V
SMAD3	V	V		V
SMAD4	V	V		V
MLH1	V	V		V	V		V
MSH2	V	V		V
AXIN1	V				V		V
RHOA	V				V		V
BIRC5	V	V	V
MYC	V	V		V
MAP2K1	V				V	V
BCL2	V	V		V
TP53	V	V		V
LEF1	V	V		V
GSK3B	V	V	V
AKT2	V				V		V
MSH6	V	V		V
MSH3	V	V		V
TGFBR2	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
BCL2L11	V				V		V
RALA	V				V		V
CASP3								V
MAPK1								V
EGFR								V
+ 05212: Pancreatic cancer	2.3	1.6	1.4	1	1.6	0.8	1.5	3.3	0	0
PIK3CB	V	V	V
AKT2	V				V		V
MAP2K1	V				V	V
RALA	V				V		V
RALBP1	V				V		V
JAK1	V				V		V
STAT1	V	V		V
TGFB3	V				V		V
TGFBR2	V	V		V
SMAD3	V	V		V
SMAD4	V	V		V
RAD51	V	V	V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
BCL2L1								V
MAPK1								V
RB1								V
EGFR								V
+ 05225: Hepatocellular carcinoma	3.1	3.3	3	1.9	0.3	0.4	0.3	3.6	0.5	0.5
MAP2K1	V				V	V
SHC3	V	V	V
IGF1R	V				V		V
PIK3CB	V	V	V
AKT2	V				V		V
MYC	V	V		V
LEF1	V	V		V
CSNK1A1	V
AXIN1	V				V		V
GSK3B	V	V	V
FRAT1	V	V	V
WNT1	V	V	V
WNT8B	V	V	V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
PLCG1	V	V		V
PRKCA	V	V		V				V
TGFB3	V				V		V
SMAD3	V	V		V
SMAD4	V	V		V
TGFBR2	V	V		V
SMARCC1	V	V		V
SMARCA2	V	V		V
KEAP1	V	V		V
GSTP1	V				V		V
GSTO1	V	V	V
ACTB	V	V	V						V	V
ACTG1	V	V	V
SMARCD3	V	V	V
SMARCE1	V	V		V
BRD7	V	V		V
EGFR								V
MAPK1								V
RB1								V
PRKCB								V
BCL2L1								V
+ 05226: Gastric cancer	2.2	2.7	1.9	1.9	0.3	0.4	0.3	2	0.5	0.5
MAP2K1	V				V	V
SHC3	V	V	V
PIK3CB	V	V	V
AKT2	V				V		V
MYC	V	V		V
LEF1	V	V		V
CSNK1A1	V
AXIN1	V				V		V
GSK3B	V	V	V
FRAT1	V	V	V
WNT1	V	V	V
WNT8B	V	V	V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
TGFB3	V				V		V
SMAD3	V	V		V
SMAD4	V	V		V
TGFBR2	V	V		V
JUP	V	V		V
CDKN1B	V	V		V
BCL2	V	V		V
RARB	V	V		V
MLH1	V	V		V	V		V
ABCB1	V	V		V
MAPK1								V
RB1								V
EGFR								V
SHH									V	V
+ 05214: Glioma	2.6	2.2	1.4	1.8	2.4	1.6	1.9	4	0	0
PDGFRB	V				V	V
IGF1R	V				V		V
CALM1	V	V		V	V		V
CALM2	V	V		V	V		V
CALM3	V	V		V	V		V
CAMK4	V	V		V
CAMK2D	V				V		V
PRKCA	V	V		V				V
SHC3	V	V	V
MAP2K1	V				V	V
PIK3CB	V	V	V
AKT2	V				V		V
TP53	V	V		V
PLCG1	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
EGFR								V
PRKCB								V
MAPK1								V
RB1								V
+ 05216: Thyroid cancer	1.9	1.9	1.1	1.6	1.2	1.2	0.8	1.3	0	0
MAP2K1	V				V	V
MYC	V	V		V
CCDC6	V	V		V	V		V
NCOA4	V				V		V
LEF1	V	V		V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
MAPK1								V
+ 05221: Acute myeloid leukemia	2.4	2.2	2.6	0.8	1	0.9	0.8	1.9	1	1
MYC	V	V		V
JUP	V	V		V
LEF1	V	V		V
PIM2	V				V		V
AKT2	V				V		V
PIK3CB	V	V	V
MAP2K1	V				V	V
CEBPE	V	V	V
BCL2A1	V	V	V
PER2	V	V		V
ITGAM	V	V	V
DUSP6	V				V		V
MPO	V	V	V
CSF2	V	V	V
MAPK1								V
CD14								V
CEBPA									V	V
+ 05220: Chronic myeloid leukemia	3.1	3.5	2.3	2.6	0.8	0.8	0.6	3.3	0	0
PTPN11	V	V		V
TP53	V	V		V
TGFB3	V				V		V
HDAC1	V	V		V
HDAC2	V	V		V
MYC	V	V		V
TGFBR2	V	V		V
SMAD4	V	V		V
NFKBIA	V	V	V
CDKN1B	V	V		V
SHC3	V	V	V
GAB2	V	V	V		V		V
SMAD3	V	V		V
AKT2	V				V		V
PIK3CB	V	V	V
MAP2K1	V				V	V
GADD45A	V	V	V
GADD45B	V	V	V
BCL2L1								V
CRK								V
RB1								V
MAPK1								V
+ 05217: Basal cell carcinoma	1.1	1.6	2.2	0.5	0.1	0	0.1	0	1	1
PTCH1	V	V		V
WNT1	V	V	V
WNT8B	V	V	V
AXIN1	V				V		V
GSK3B	V	V	V
LEF1	V	V		V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
SHH									V	V
+ 05218: Melanoma	1	0.7	1.5	0.2	0.9	1.6	0.3	2.7	0	0
IGF1R	V				V		V
PDGFRB	V				V	V
PDGFC	V	V	V
PDGFD	V	V		V
TP53	V	V		V
AKT2	V				V		V
PIK3CB	V	V	V
MAP2K1	V				V	V
GADD45A	V	V	V
GADD45B	V	V	V
EGFR								V
RB1								V
MAPK1								V
+ 05211: Renal cell carcinoma	2	0.5	0.6	0.4	2.5	0.8	2.5	1.9	0	0
PTPN11	V	V		V
TGFB3	V				V		V
EP300	V	V		V
EGLN1	V				V		V
EPAS1	V	V	V
BUB1B-PAK6	V				V		V
PAK6	V				V		V
PAK1	V				V		V
ETS1	V	V		V
AKT2	V				V		V
PIK3CB	V	V	V
MAP2K1	V				V	V
TFE3	V				V		V
CRK								V
MAPK1								V
+ 05219: Bladder cancer	0.4	0.5	0.4	0.5	0.2	1.1	0	3.9	0	0
MMP9	V	V	V
MYC	V	V		V
TP53	V	V		V
MAP2K1	V				V	V
CXCL8								V
EGFR								V
RB1								V
MAPK1								V
+ 05215: Prostate cancer	3.7	3	2.4	2	1.8	2.1	1.1	3.7	0	0
NFKBIA	V	V	V
CDKN1B	V	V		V
BCL2	V	V		V
LEF1	V	V		V
EP300	V	V		V
FOXO1	V	V		V
TP53	V	V		V
IGF1R	V				V		V
PDGFRB	V				V	V
ATF4	V	V	V
CREB5	V				V	V
PDGFC	V	V	V
PDGFD	V	V		V
GSK3B	V	V	V
HSP90AA1	V				V		V
HSP90AB1	V	V		V
HSP90B1	V				V		V
AKT2	V				V		V
PIK3CB	V	V	V
GSTP1	V				V		V
MAP2K1	V				V	V
ETV5	V	V		V
MMP9	V	V	V
IL1R2	V	V	V
EGFR								V
CREB1								V
RB1								V
MAPK1								V
TMPRSS2								V
+ 05213: Endometrial cancer	2.2	2.2	2.3	1	1.1	0.9	0.9	2	0	0
AXIN1	V				V		V
GSK3B	V	V	V
FOXO3	V	V	V
LEF1	V	V		V
MLH1	V	V		V	V		V
MYC	V	V		V
AKT2	V				V		V
PIK3CB	V	V	V
MAP2K1	V				V	V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
EGFR								V
MAPK1								V
+ 05224: Breast cancer	1	0.8	2.3	0	0.7	0.4	0.8	2.6	0	0.5
NCOA1	V				V		V
MAP2K1	V				V	V
SHC3	V	V	V
NOTCH1	V				V		V
NOTCH3	V	V	V		V		V
IGF1R	V				V		V
PIK3CB	V	V	V
AKT2	V				V		V
MYC	V	V		V
LEF1	V	V		V
CSNK1A1	V
AXIN1	V				V		V
GSK3B	V	V	V
FRAT1	V	V	V
WNT1	V	V	V
WNT8B	V	V	V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
ESR1								V
EGFR								V
MAPK1								V
RB1								V
SP1										V
+ 05222: Small cell lung cancer	2.9	3.2	2	2.5	0.5	1.4	0.2	3.1	0.8	1.6
ITGA6	V	V		V
ITGA2B	V	V	V
CDKN1B	V	V		V
RARB	V	V		V
AKT2	V				V		V
MYC	V	V		V
PIK3CB	V	V	V
FN1	V				V	V		V
LAMA3	V				V	V			V	V
LAMA4	V				V		V
LAMB3	V	V	V
BIRC3	V	V		V
XIAP	V	V		V
BCL2	V	V		V
NFKBIA	V	V	V
TRAF1	V	V		V
TRAF5	V	V		V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
BCL2L1								V
RB1								V
CASP3								V
LAMC2										V
+ 05223: Non-small cell lung cancer	1.5	1.9	1.6	1.2	0.3	0.9	0.1	4.1	0	0
PRKCA	V	V		V				V
FOXO3	V	V	V
AKT2	V				V		V
PIK3CB	V	V	V
PLCG1	V	V		V
RARB	V	V		V
MAP2K1	V				V	V
EML4	V	V		V
TP53	V	V		V
GADD45A	V	V	V
GADD45B	V	V	V
PRKCB								V
EGFR								V
RB1								V
MAPK1								V
+ 6.12 Drug resistance: antineoplastic	5.7	5	5.1	2.6	3.3	2.1	2.8	7	0	0.4
+ 01521: EGFR tyrosine kinase inhibitor resistance	3	1.5	1.8	0.6	2.7	2.3	1.8	4.5	0	0
GSK3B	V	V	V
SHC3	V	V	V
PRKCA	V	V		V				V
PLCG1	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
MAP2K1	V				V	V
NF1	V				V		V
IGF1R	V				V		V
PDGFRB	V				V	V
JAK1	V				V		V
BCL2	V	V		V
BCL2L11	V				V		V
PDGFC	V	V	V
PDGFD	V	V		V
AXL	V				V	V
RPS6	V				V		V
FOXO3	V	V	V
EGFR								V
PRKCB								V
MAPK1								V
BCL2L1								V
IL6								V
+ 01524: Platinum drug resistance	3.8	4.2	1.5	4.1	0.8	0	1.1	2.6	0	0
ATM	V	V		V
TP53	V	V		V
BCL2	V	V		V
BIRC3	V	V		V
XIAP	V	V		V
BIRC5	V	V	V
CASP8	V	V		V
FASLG	V	V		V
GSTP1	V				V		V
GSTO1	V	V	V
MLH1	V	V		V	V		V
XPA	V	V		V
ERCC1	V				V		V
TOP2A	V	V	V
MSH2	V	V		V
MSH6	V	V		V
MSH3	V	V		V
PIK3CB	V	V	V
AKT2	V				V		V
REV3L	V	V		V
CASP3								V
BCL2L1								V
MAPK1								V
+ 01523: Antifolate resistance	2	2.3	3.8	0	0.9	1.3	0.4	2.5	0	0
FOLR3	V	V	V
SLC19A1	V	V	V
GGH	V	V	V
TYMS	V	V	V		V	V
IL1B	V				V		V
TNF	V	V	V					V
ALOX12	V	V	V
IL6								V
+ 01522: Endocrine resistance	2.7	2.1	3.2	0.4	2.2	0.6	2.2	4.3	0	0.8
GPER1	V	V	V					V
MMP9	V	V	V
MED1	V				V		V
PRKACA	V				V		V
PRKACB	V	V		V
MAP2K1	V				V	V
SHC3	V	V	V
GNAS	V	V	V		V		V
ADCY7	V				V		V
PIK3CB	V	V	V
AKT2	V				V		V
MAPK14	V	V	V					V
NOTCH1	V				V		V
NOTCH3	V	V	V		V		V
TP53	V	V		V
CDKN2C	V	V	V
CDKN1B	V	V		V
IGF1R	V				V		V
BCL2	V	V		V
BIK	V	V	V
ESR1								V
EGFR								V
MAPK1								V
RB1								V
SP1										V

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