Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	LPS_vs_231_UP	LPS_vs_231_DOWN	I5409_vs_231+LPS_UP	I5409_vs_231+LPS_DOWN	JMY104_vs_231+LPS_UP	JMY104_vs_231+LPS_DOWN	LPS_vs_2Lung_UP	LPS_vs_2Lung_DOWN	I5409_vs_2Lung_UP	I5409_vs_2Lung_DOWN	JMY104_vs_2Lung_UP	JMY104_vs_2Lung_DOWN	IRAK1_KO_vs_2Lung_UP	IRAK1_KO_vs_2Lung_DOWN
	384/845	390/927	375/860	369/774	361/740	364/815	359/825	346/767	315/726	377/846	325/752	357/844	444/1031	385/839
+ 1. Metabolism	4.8	7.4	7.3	4.6	4.4	5.8	4.8	5.1	4.3	7.5	6.1	4.5	7.1	4.3
+ 1.0 Global and overview maps	3.3	4.8	3.8	1.8	1.7	3.2	2.1	1.9	2.2	3.9	3.8	1.9	3.5	1.8
+ 01100: Metabolic pathways	0.8	2.7	2.8	0.6	1.3	1.1	1	1.3	0.8	2.3	2	0.8	3.4	0.5
SDHA	V			V	V					V				V
FKTN	V		V		V		V
HSD17B12	V											V
ELOVL5	V					V	V			V				V
SHMT1	V					V				V		V	V
RRM2	V			V		V		V			V		V
GSTM1	V			V								V
GSTO1	V			V		V								V
TXNDC12	V			V		V		V			V			V
PI4KB	V					V	V			V		V	V
PIP5K1A	V		V					V	V		V			V
ITPK1	V			V		V
ACADM	V				V						V
LDHA	V						V			V
NIT2	V			V	V									V
NME2	V								V		V
GMPR2	V					V		V	V		V			V
MDH1	V			V						V				V
PGM3	V				V									V
AK5	V					V		V	V		V			V
PFKM	V		V			V	V				V			V
LPIN2	V					V
UGP2	V												V
ACO1	V								V
GFPT2	V
AMD1	V
DLST	V					V	V			V
HSD17B1	V			V
RPE	V			V		V								V
RPEL1	V
CTPS1	V					V		V	V		V		V
UCKL1	V					V	V			V		V	V
SEPHS1	V		V						V		V		V
MBOAT2	V			V
PAFAH1B2	V						V			V		V	V
SPTLC1	V					V
ALOX5	V			V
PTGES3	V			V		V		V	V		V			V
PTGES2	V						V						V
NADSYN1	V					V			V
NADK2	V		V					V		V	V		V
RPN2	V			V					V					V
TUSC3	V						V				V		V
MAN2A2	V					V	V					V	V
GBA	V		V				V			V		V		V
PNPO	V				V								V
ADPGK	V					V
PRPS1L1	V			V		V
PRPS1	V			V		V
COQ5	V					V					V		V
HPSE	V			V	V								V
SUCLG2	V			V			V			V
ACOT1	V					V			V				V
DSE	V
B3GAT3	V		V		V			V	V		V
ST3GAL4	V					V		V	V
DHFR	V					V	V			V		V		V
AMPD3	V
AK6	V					V		V	V		V			V
PYCR3	V						V			V			V
ATP5ME	V
NDUFC2-KCTD14	V		V			V	V			V
NDUFV1	V
NDUFA13	V
SDHC		V			V				V		V
KYAT3		V			V		V			V		V
POMT1		V	V		V						V			V
GMPPB		V
PLD3		V		V					V
HACD1		V
ACAA1		V				V			V
ACOX1		V
ALDOA		V	V		V		V			V		V
RRM2B		V	V
MGST2		V	V		V					V		V
GGT5		V
GPX1		V	V
SCLY		V	V					V	V		V
ALDH3B1		V	V
INPP4B		V
PIK3C2A		V						V
MTMR14		V		V			V					V
PIKFYVE		V			V		V			V
PIP4K2C		V	V					V
PIP4K2B		V												V
BCAT1		V	V			V	V			V	V
BCAT2		V
NT5C		V
DTYMK		V	V
PDE8A		V		V	V						V		V
NME7		V	V					V					V
ENTPD6		V
GUK1		V				V							V
ADSL		V	V		V		V			V		V
GRHPR		V	V		V							V
ACACA		V		V						V	V			V
ELOVL1		V								V		V		V
PDHX		V						V					V
HMOX2		V	V		V							V
COX15		V
B3GALNT2		V					V			V		V	V
FKRP		V						V	V		V
B4GALT3		V			V
B4GALT2		V												V
GCLM		V	V
GCSH		V	V		V			V	V		V
ALPP		V
ACP1		V	V		V
RIMKLB		V	V								V
PHYKPL		V											V
DGKA		V		V		V
DGKZ		V	V		V				V			V
COMT		V	V		V
PGD		V
GFPT1		V		V	V			V	V		V
PHGDH		V
DNMT3A		V	V
ASL		V					V		V			V
AUH		V	V
ACSL1		V			V		V			V				V
BDH1		V	V		V								V
CYP51A1		V	V		V			V					V
TKT		V						V	V		V			V
FBP1		V
GAPDH		V	V		V								V
UCK1		V	V							V				V
SMPD1		V				V						V
CBR1		V			V			V		V
NAPRT		V								V		V	V
DDOST		V	V		V		V			V		V	V
GALNT2		V	V				V							V
PC		V										V
UPRT		V	V		V
GART		V	V		V			V	V					V
EXTL3		V	V				V
AHCYL1		V			V
ODC1		V									V
PIGX		V
PIGV		V
PIGT		V	V		V			V	V		V			V
ALAD		V	V		V				V		V
AMPD2		V	V		V
ACP2		V				V
PCCB		V
ECHDC1		V	V		V		V			V		V
PYCR1		V					V			V		V	V
ATP5F1A		V	V					V	V		V			V
ATP5F1D		V
ATP5PB		V	V		V							V
ATP5PF		V	V		V
NDUFAB1		V	V		V
NDUFC1		V		V				V	V		V		V
SDHD			V					V						V
GLB1			V		V					V		V
GSTM4			V										V
GSR			V					V	V
G6PC3			V		V			V						V
MTMR4			V		V						V
TYMP			V
ITPA			V		V		V			V
NME6			V											V
PKM			V		V			V	V				V
ESD			V
PFKFB3			V			V							V
MGAT5B			V
GUSB			V
POMGNT1			V		V								V
NFS1			V		V		V			V		V
AK2			V		V			V			V
HIBADH			V					V
HIBCH			V								V		V
FDFT1			V				V		V
NANS			V		V								V
AOX1			V							V
MCCC1			V		V		V						V
ACADVL			V		V
EBP			V		V					V		V
ALG8			V						V		V
PCK2			V		V		V							V
IDH1			V
OGDH			V			V				V				V
NAMPT			V				V			V			V
NQO1			V										V
ADK			V
AMDHD2			V				V			V		V
H6PD			V
ATP5PD			V
ATP6V0A4			V											V
NDUFB3			V
FADS2				V
GSTT2B				V		V	V			V		V
ALDH3A2				V				V		V	V		V
MTMR1				V		V								V
PLCG1				V
UROS				V								V
UMPS				V		V		V
IMPDH1				V	V					V
ATIC				V		V
HADHB				V		V		V	V		V
FUT4				V
AK4				V				V		V	V		V
LPIN1				V		V		V			V
LSS				V		V		V	V				V
ETNK2				V		V	V			V		V
LPCAT4				V
LPCAT1				V								V
PRXL2B				V
MGLL				V		V				V
OAT				V		V						V
GK				V		V
GCK				V		V
TPI1				V
MPI				V
EXT2				V				V			V			V
HYAL1				V
GYG1				V	V		V			V		V	V
DGUOK				V										V
P4HA1				V				V	V		V		V
ATP5F1C				V
ATP5MF				V								V
NDUFA12				V		V			V		V		V
PLCB3					V						V		V
IMPA1					V							V
TSTA3					V				V				V
DGAT1					V					V				V
PANK2					V			V	V
HMGCR					V
SCP2						V					V		V
ALDOC						V							V
ADCY7						V								V
PFKFB2						V				V		V
MGAM						V					V
B4GALT1						V				V
IDUA						V
XYLT2						V
MTHFD1						V	V						V
PLAAT3						V							V
CERS2						V		V	V		V
HLCS						V
NDST1						V		V			V
VKORC1L1						V
ATP6V1D						V						V	V
NDUFB2						V	V			V			V
HSD17B4							V						V
NAT8							V			V
AOC2							V			V		V
UPP1							V			V			V
NT5C3A							V			V
NUDT5							V						V
NUDT9							V			V		V
CA5B							V
GLA							V			V
ENOSF1							V				V		V
GPI							V			V		V
CEPT1							V			V		V
AZIN2							V				V
PCYT2							V
AGPAT1							V
FDPS							V						V
LTA4H							V						V
DUT							V
GALNS							V			V		V
ARSB							V					V
PIGO							V
GNPNAT1							V						V
COX7A2							V			V	V		V
DERA								V	V		V		V
DPM1								V		V		V		V
CYP1A1								V			V
PLPP1								V	V				V
UGDH								V					V
ADH4								V
ADH7								V
MCCC2								V						V
ACSL5								V	V
SC5D								V
UCK2								V			V
AGK								V					V
TRIT1								V			V		V
CHSY1								V						V
MLYCD								V	V
IDH3B								V			V
SPAM1								V						V
HYAL3								V						V
G6PD								V					V
NDUFS5								V	V		V			V
MARS									V		V		V
MIF									V		V		V
ALAS1									V
DCXR									V
GSTZ1									V				V
ASNS									V		V
MVK									V				V
AGPAT3									V
PTDSS2									V
MOCS2									V
MECR										V
IPMK										V			V
MPST										V		V
CA12										V			V
DGKD										V		V
GNE										V
CYP27B1										V
GPAM										V
PAFAH1B3										V
POC1B-GALNT4										V
GALNT4										V
GALNT11										V
ENO2										V
GLUD1										V
COQ7										V
TCIRG1										V
NDUFA11										V		V	V
ALDOB											V
PIK3CA											V
PAICS											V
THTPA											V
GNPDA2											V
DHCR7											V		V
SPHK1											V
ATP5MC3											V		V
KYAT1												V
GPX8												V
FIG4												V	V
NT5C3B												V		V
ENTPD1												V
HDDC3												V
CMPK1												V
PEMT												V
ST3GAL1												V
HSD17B10												V
GATB												V
CS												V
NDUFA6												V
HADHA													V
HADH													V
GMPPA													V
SCD													V
MGST1													V
PGM1													V
MINPP1													V
KYNU													V
CA9													V
ELOVL7													V
CHPT1													V
FUT8													V
UAP1													V
MRI1													V
MSMO1													V
PTGS2													V
NADK													V
CEL													V
ST6GAL1													V
GALNT3													V
ST3GAL6													V
ST3GAL5													V
SPHK2													V
ENO1													V
RDH11													V
COX7B2													V
ATP6V0B													V
SYNJ2														V
FHIT														V
BPNT1														V
CKM														V
PSPH														V
AMACR														V
AGPAT2														V
LCLAT1														V
CYP2E1														V
GALNT14														V
ST6GALNAC4														V
GLCE														V
NAT1														V
+ 01200: Carbon metabolism	2.8	2.2	2.4	1.6	1	2.2	0.6	1	0.8	2.1	1.4	0.5	1.1	1.5
RPE	V			V		V								V
RPEL1	V
PFKM	V		V			V	V				V			V
ADPGK	V					V
MDH1	V			V						V				V
SDHA	V			V	V					V				V
SUCLG2	V			V			V			V
ACO1	V								V
SHMT1	V					V				V		V	V
PRPS1L1	V			V		V
PRPS1	V			V		V
DLST	V					V	V			V
ALDOA		V	V		V		V			V		V
TKT		V						V	V		V			V
GAPDH		V	V		V								V
FBP1		V
PGD		V
SDHC		V			V				V		V
PCCB		V
PHGDH		V
GCSH		V	V		V			V	V		V
PC		V										V
ACOX1		V
H6PD			V
PKM			V		V			V	V				V
SDHD			V					V						V
IDH1			V
ESD			V
OGDH			V			V				V				V
HIBCH			V								V		V
GCK				V		V
TPI1				V
ALDOC						V							V
GPI							V			V		V
G6PD								V					V
IDH3B								V			V
ENO2										V
GLUD1										V
ALDOB											V
CS												V
ENO1													V
HADHA													V
PSPH														V
+ 01210: 2-Oxocarboxylic acid metabolism	0.6	1.2	1.3	0	0	0.6	0.6	0.6	0.7	0.6	1.4	0.6	0	0
ACO1	V								V
BCAT1		V	V			V	V			V	V
BCAT2		V
IDH1			V
IDH3B								V			V
CS												V
+ 01212: Fatty acid metabolism	0.7	1.9	0.3	0.8	0.9	1.2	0.8	0.8	1.4	2.1	1.8	0.7	1.7	1.2
HSD17B12	V											V
ELOVL5	V					V	V			V				V
ACADM	V				V						V
HACD1		V
ELOVL1		V								V		V		V
ACAA1		V				V			V
ACOX1		V
ACACA		V		V						V	V			V
ACSL1		V			V		V			V				V
CPT1C			V					V	V		V
ACADVL			V		V
HADHB				V		V		V	V		V
FADS2				V
SCP2						V					V		V
HSD17B4							V						V
ACSL5								V	V
MECR										V
CPT1A										V		V
ELOVL7													V
HADHA													V
HADH													V
SCD													V
+ 01230: Biosynthesis of amino acids	2.4	2.6	1.6	0.9	0.6	2.1	1.6	0.6	1.4	1.6	1.8	1.6	1.6	0.8
PFKM	V		V			V	V				V			V
RPE	V			V		V								V
RPEL1	V
PRPS1L1	V			V		V
PRPS1	V			V		V
SHMT1	V					V				V		V	V
ACO1	V								V
PYCR3	V						V			V			V
GAPDH		V	V		V								V
ALDOA		V	V		V		V			V		V
TKT		V						V	V		V			V
BCAT1		V	V			V	V			V	V
BCAT2		V
PHGDH		V
PC		V										V
ASL		V					V		V			V
PYCR1		V					V			V		V	V
PKM			V		V			V	V				V
IDH1			V
TPI1				V
ALDOC						V							V
IDH3B								V			V
ASNS									V		V
ENO2										V
ALDOB											V
CS												V
ENO1													V
PSPH														V
+ 1.1 Carbohydrate metabolism	3.6	3.1	3.5	3.2	3.2	2.9	2.9	2.4	1.4	3.9	3	2	4.1	2.6
+ 00010: Glycolysis / Gluconeogenesis	0.6	0.8	2.2	0.7	1.6	1	1.4	1.5	0.1	1.4	0.7	0.3	1.8	0.6
LDHA	V						V			V
PFKM	V		V			V	V				V			V
ADPGK	V					V
ALDOA		V	V		V		V			V		V
ALDH3B1		V	V
GAPDH		V	V		V								V
FBP1		V
PKM			V		V			V	V				V
G6PC3			V		V			V						V
PCK2			V		V		V							V
ALDH3A2				V				V		V	V		V
TPI1				V
GCK				V		V
ALDOC						V							V
GPI							V			V		V
ADH4								V
ADH7								V
ENO2										V
ALDOB											V
ENO1													V
PGM1													V
MINPP1													V
+ 00020: Citrate cycle (TCA cycle)	2.6	0.8	2	1.6	1.6	0.9	1.5	1	1	2.6	1	0.9	0	2.6
DLST	V					V	V			V
SUCLG2	V			V			V			V
ACO1	V								V
MDH1	V			V						V				V
SDHA	V			V	V					V				V
PC		V										V
SDHC		V			V				V		V
OGDH			V			V				V				V
IDH1			V
PCK2			V		V		V							V
SDHD			V					V						V
IDH3B								V			V
CS												V
+ 00030: Pentose phosphate pathway	2.6	1.9	1.4	1.6	0.4	2.7	1.5	1.6	1	0.9	2.2	0.9	1.8	1.5
PRPS1L1	V			V		V
PRPS1	V			V		V
RPE	V			V		V								V
RPEL1	V
PFKM	V		V			V	V				V			V
TKT		V						V	V		V			V
ALDOA		V	V		V		V			V		V
FBP1		V
PGD		V
H6PD			V
ALDOC						V							V
GPI							V			V		V
DERA								V	V		V		V
G6PD								V					V
ALDOB											V
PGM1													V
+ 00040: Pentose and glucuronate interconversions	1.3	0	0.3	0.3	0	0.3	0	0.3	0.3	0	0	0	0.6	0.3
RPE	V			V		V								V
RPEL1	V
UGP2	V												V
GUSB			V
UGDH								V					V
DCXR									V
+ 00051: Fructose and mannose metabolism	0.3	1.3	1.3	0.9	0.9	2	1.4	0	0.4	0.8	1.5	0.8	2.2	0.3
PFKM	V		V			V	V				V			V
GMPPB		V
ALDOA		V	V		V		V			V		V
FBP1		V
PFKFB3			V			V							V
MPI				V
TPI1				V
TSTA3					V				V				V
PFKFB2						V				V		V
ALDOC						V							V
ENOSF1							V				V		V
ALDOB											V
GMPPA													V
+ 00052: Galactose metabolism	0.8	0.3	1.4	0.4	1	2	0.9	0.4	0	1.4	0.9	0.3	0.7	1.4
PFKM	V		V			V	V				V			V
UGP2	V												V
B4GALT2		V												V
GLB1			V		V					V		V
G6PC3			V		V			V						V
GCK				V		V
MGAM						V					V
B4GALT1						V				V
GLA							V			V
PGM1													V
+ 00053: Ascorbate and aldarate metabolism	0	0	0	0.4	0	0	0	1.1	0	0.4	0.4	0	0.8	0
ALDH3A2				V				V		V	V		V
UGDH								V					V
+ 00500: Starch and sucrose metabolism	0.3	0	0.2	0.8	0.8	0.7	0.7	0.3	0	0.7	0.3	0.7	1	0.3
UGP2	V												V
G6PC3			V		V			V						V
GYG1				V	V		V			V		V	V
GCK				V		V
MGAM						V					V
GPI							V			V		V
PGM1													V
+ 00520: Amino sugar and nucleotide sugar metabolism	1.4	0.4	0.5	1.5	1.6	0.5	1	1	0.6	1.4	1.1	0.5	2.9	0.1
PGM3	V				V									V
GFPT2	V
CYB5R3	V			V		V		V			V
UGP2	V												V
GFPT1		V		V	V			V	V		V
GMPPB		V
NANS			V		V								V
AMDHD2			V				V			V		V
MPI				V
GCK				V		V
TSTA3					V				V				V
GNPNAT1							V						V
GPI							V			V		V
UGDH								V					V
GNE										V
CYB5R4										V
GNPDA2											V
UAP1													V
PGM1													V
GMPPA													V
+ 00620: Pyruvate metabolism	0.7	1.1	1.1	1.3	1.3	0	0.7	0.7	0.3	1.7	0.7	0.7	0.5	1.2
MDH1	V			V						V				V
LDHA	V						V			V
PC		V										V
ACACA		V		V						V	V			V
GRHPR		V	V		V							V
PCK2			V		V		V							V
PKM			V		V			V	V				V
ALDH3A2				V				V		V	V		V
+ 00630: Glyoxylate and dicarboxylate metabolism	1.5	1.4	0.9	0.4	1	0.4	0	0.4	1	0.9	0.4	1.5	0.3	0.4
ACO1	V								V
MDH1	V			V						V				V
SHMT1	V					V				V		V	V
GRHPR		V	V		V							V
PCCB		V
GCSH		V	V		V			V	V		V
CS												V
+ 00640: Propanoate metabolism	0.8	1.8	0.8	0.8	0.3	0	1.3	0.3	0.3	1.9	0.9	0.3	0.6	0.3
LDHA	V						V			V
SUCLG2	V			V			V			V
ACACA		V		V						V	V			V
PCCB		V
ECHDC1		V	V		V		V			V		V
ACOX1		V
HIBCH			V								V		V
MLYCD								V	V
HADHA													V
+ 00650: Butanoate metabolism	0	0.3	0.4	0	0.4	0	0	0	0	0	0	0	1.3	0
BDH1		V	V		V								V
HADH													V
HADHA													V
+ 00562: Inositol phosphate metabolism	0.5	1.5	0.5	1.4	1	0.5	0.5	0.6	0.1	0.5	1	0.8	0.9	0.8
ITPK1	V			V		V
PI4KB	V					V	V			V		V	V
PIP5K1A	V		V					V	V		V			V
PIP4K2C		V	V					V
PIP4K2B		V												V
INPP4B		V
MTMR14		V		V			V					V
PIKFYVE		V			V		V			V
PIK3C2A		V						V
MTMR4			V		V						V
MTMR1				V		V								V
PLCG1				V
TPI1				V
IMPA1					V							V
PLCB3					V						V		V
IPMK										V			V
PIK3CA											V
FIG4												V	V
MINPP1													V
SYNJ2														V
+ 1.2 Energy metabolism	0.2	0.8	0.9	0.3	0.3	0.1	0.6	0.7	0.3	1.8	0.8	0.8	1.6	0.9
+ 00190: Oxidative phosphorylation	0.4	1.3	1.5	0.5	0.5	0.2	0.4	0.3	0.6	0.9	1.4	0.4	1.6	0.6
NDUFC2-KCTD14	V		V			V	V			V
NDUFV1	V
NDUFA13	V
ATP5ME	V
SDHA	V			V	V					V				V
NDUFC1		V		V				V	V		V		V
NDUFB6		V					V			V				V
NDUFAB1		V	V		V
COX15		V
ATP5F1A		V	V					V	V		V			V
ATP5F1D		V
ATP5PB		V	V		V							V
ATP5PF		V	V		V
SDHC		V			V				V		V
NDUFB3			V
ATP5PD			V
ATP6V0A4			V											V
SDHD			V					V						V
NDUFA12				V		V			V		V		V
ATP5F1C				V
ATP5MF				V								V
NDUFB2						V	V			V			V
ATP6V1D						V						V	V
COX7A2							V			V	V		V
PPA1							V						V
NDUFS5								V	V		V			V
NDUFA11										V		V	V
TCIRG1										V
ATP5MC3											V		V
PPA2											V		V
NDUFA6												V
COX7B2													V
ATP6V0B													V
+ 00910: Nitrogen metabolism	0	0	0	0	0	0	0.6	0	0	1.4	0	0	1.2	0
CA5B							V
CA12										V			V
GLUD1										V
CA9													V
+ 00920: Sulfur metabolism	0	0	0	0	0	0	0	1	0	0.9	0	0.9	0	0.9
SELENBP1								V
MPST										V		V
BPNT1														V
+ 1.3 Lipid metabolism	1.7	2.3	1.4	2.6	1.5	3.2	1.9	2.3	2.8	3.2	1.7	1.9	4.1	1.6
+ 00061: Fatty acid biosynthesis	0	1.2	0	0.6	0.7	0	0.6	0.6	0.7	2	0.7	0	0	1.3
ACACA		V		V						V	V			V
ACSL1		V			V		V			V				V
ACSL5								V	V
MECR										V
+ 00062: Fatty acid elongation	1.6	0.9	0.4	0.4	0	1.6	0.4	0.4	1.1	1.6	0.4	1	1.9	1
HSD17B12	V											V
ACOT1	V					V			V				V
ELOVL5	V					V	V			V				V
HACD1		V
ELOVL1		V								V		V		V
ACOT7			V
HADHB				V		V		V	V		V
MECR										V
HADHA													V
HADH													V
ELOVL7													V
+ 00071: Fatty acid degradation	0.6	0.9	0.5	1.1	1.2	0.6	0.6	3.1	2.3	1.5	2.2	0.6	1.3	0.2
ACADM	V				V						V
ECI1	V			V				V	V		V
ACAA1		V				V			V
ACSL1		V			V		V			V				V
ACOX1		V
ACADVL			V		V
CPT1C			V					V	V		V
HADHB				V		V		V	V		V
ALDH3A2				V				V		V	V		V
ECI2							V			V		V	V
ADH4								V
ADH7								V
ACSL5								V	V
CPT1A										V		V
HADH													V
HADHA													V
+ 00072: Synthesis and degradation of ketone bodies	0	0.9	0.9	0	1	0	0	0	0	0	0	0	0.8	0
BDH1		V	V		V								V
+ 00100: Steroid biosynthesis	0	0.5	2	0.6	1.4	0.6	0.6	2.1	1.4	1.3	0.6	0.6	3.6	0
CYP51A1		V	V		V			V					V
EBP			V		V					V		V
FDFT1			V				V		V
LSS				V		V		V	V				V
SC5D								V
CYP27B1										V
DHCR7											V		V
MSMO1													V
CEL													V
LIPA													V
+ 00120: Primary bile acid biosynthesis	0	0	0	0	0	0.6	0.6	0	0	0	0.7	0	1.2	0.6
SCP2						V					V		V
HSD17B4							V						V
AMACR														V
+ 00140: Steroid hormone biosynthesis	0.7	0.1	0.1	0.4	0.1	0	0.1	0.1	0	0	0.1	0.1	0	0.3
HSD17B1	V			V
HSD17B12	V											V
DHRS11	V						V
COMT		V	V		V
AKR1C1				V									V
CYP1A1								V			V
CYP1B1														V
CYP2E1														V
+ 00561: Glycerolipid metabolism	0.3	0.3	0.1	2.1	0.8	1.6	0.3	1.2	0.8	2	0.4	0.3	0.8	0.7
LPIN2	V					V
MBOAT2	V			V
DGKA		V		V		V
DGKZ		V	V		V				V			V
LPIN1				V		V		V			V
MGLL				V		V				V
GK				V		V
ALDH3A2				V				V		V	V		V
DGAT1					V					V				V
PLPP5					V
AGPAT1							V
GLA							V			V
PLPP1								V	V				V
AGK								V					V
AGPAT3									V
GPAM										V
DGKD										V		V
CEL													V
AGPAT2														V
LCLAT1														V
+ 00564: Glycerophospholipid metabolism	0.3	0.2	0.5	1.7	0.4	1.6	1.2	0.3	1.4	0.5	0.1	1.5	0.8	0.1
LPIN2	V					V
MBOAT2	V			V
MBOAT7	V		V			V	V		V		V		V
DGKA		V		V		V
DGKZ		V	V		V				V			V
PLD3		V		V					V
LYPLA1			V		V		V					V	V
PNPLA6			V
LPCAT4				V
LPCAT1				V								V
ETNK2				V		V	V			V		V
LPIN1				V		V		V			V
PLPP5					V
PLAAT3						V							V
LPGAT1						V
CEPT1							V			V		V
PCYT2							V
AGPAT1							V
PLPP1								V	V				V
GPD1L								V
PTDSS2									V
AGPAT3									V
DGKD										V		V
GPAM										V
PEMT												V
CHPT1													V
LCAT													V
AGPAT2														V
LCLAT1														V
+ 00565: Ether lipid metabolism	0.2	0.1	0	1.1	0	0.2	0.5	0.2	0.6	1	0	1	1.2	0
PAFAH1B2	V						V			V		V	V
PLD3		V		V					V
LPCAT1				V								V
LPCAT4				V
PLAAT3						V							V
CEPT1							V			V		V
PLPP1								V	V				V
PAFAH1B3										V
CHPT1													V
+ 00600: Sphingolipid metabolism	1	0.1	0.5	0.2	0.2	1.5	1	0.6	0.6	1.4	0.6	1.4	0.4	0.2
ACER3	V			V		V	V			V		V
SPTLC1	V					V
GBA	V		V				V			V		V		V
SMPD1		V				V						V
GLB1			V		V					V		V
CERS2						V		V	V		V
GLA							V			V
PLPP1								V	V				V
SPHK1											V
SPHK2													V
+ 00590: Arachidonic acid metabolism	0.7	0.6	0.1	0.7	0.1	0.3	0.3	0.4	0.1	0.1	0.1	0.1	0.8	0.3
ALOX5	V			V
PTGES3	V			V		V		V	V		V			V
PTGES2	V						V						V
GPX1		V	V
GGT5		V
CBR1		V			V			V		V
PRXL2B				V
PLAAT3						V							V
LTA4H							V						V
GPX8												V
PTGS2													V
CYP2E1														V
+ 00591: Linoleic acid metabolism	0	0	0	0	0	0.4	0	0	0	0	0	0	0.3	0.4
PLAAT3						V							V
CYP2E1														V
+ 00592: alpha-Linolenic acid metabolism	0	1	0	0.5	0	1.1	0	0	0.5	0	0	0	0.3	0
ACOX1		V
ACAA1		V				V			V
FADS2				V
PLAAT3						V							V
+ 01040: Biosynthesis of unsaturated fatty acids	1.6	2.1	0.4	0.4	0	2.2	1	0	1.1	1	0.4	1	2.5	1
HSD17B12	V											V
ACOT1	V					V			V				V
ELOVL5	V					V	V			V				V
HACD1		V
ACAA1		V				V			V
ACOX1		V
ELOVL1		V								V		V		V
ACOT7			V
FADS2				V
SCP2						V					V		V
HSD17B4							V						V
ELOVL7													V
SCD													V
+ 1.4 Nucleotide metabolism	1.9	2.6	3.1	1.3	1.2	2.3	1.2	2.8	1.2	1.3	2.5	1.1	1.5	1.9
+ 00230: Purine metabolism	1.6	1.4	1.9	1.4	1.5	2	0.5	2.1	1.2	0.7	2.2	0.4	0.9	1.9
RRM2	V			V		V		V			V		V
PRPS1L1	V			V		V
PRPS1	V			V		V
NME2	V								V		V
AK6	V					V		V	V		V			V
AK5	V					V		V	V		V			V
AMPD3	V
GMPR2	V					V		V	V		V			V
AK3	V					V		V	V		V			V
RRM2B		V	V
GART		V	V		V			V	V					V
ADSL		V	V		V		V			V		V
NME7		V	V					V					V
AMPD2		V	V		V
NT5C		V
ENTPD6		V
GUK1		V				V							V
PDE8A		V		V	V						V		V
NME6			V											V
AK2			V		V			V			V
ADK			V
ITPA			V		V		V			V
PKM			V		V			V	V				V
ATIC				V		V
AK4				V				V		V	V		V
IMPDH1				V	V					V
DGUOK				V										V
ADCY7						V								V
NT5C3A							V			V
NUDT5							V						V
NUDT9							V			V		V
PAICS											V
ENTPD1												V
NT5C3B												V		V
HDDC3												V
PGM1													V
FHIT														V
+ 00240: Pyrimidine metabolism	1.2	2.3	2.5	0.4	0.1	1.2	1.2	1.8	0.5	1.2	1.3	1.2	1.3	0.7
RRM2	V			V		V		V			V		V
NME2	V								V		V
CTPS1	V					V		V	V		V		V
UCKL1	V					V	V			V		V	V
RRM2B		V	V
NME7		V	V					V					V
ENTPD6		V
UPRT		V	V		V
UCK1		V	V							V				V
NT5C		V
DTYMK		V	V
NME6			V											V
TYMP			V
UMPS				V		V		V
NT5C3A							V			V
UPP1							V			V			V
DUT							V
UCK2								V			V
CMPK1												V
ENTPD1												V
NT5C3B												V		V
+ 1.5 Amino acid metabolism	1.1	3.6	2.5	1.4	1.1	1.2	2	1.5	2.1	3.1	3	1.5	2.3	0.3
+ 00250: Alanine, aspartate and glutamate metabolism	0.7	1.7	0.7	0.8	1.4	0	0.7	0.3	1.4	0.7	1.4	0.7	0	0.3
NIT2	V			V	V									V
GFPT2	V
ASL		V					V		V			V
ADSL		V	V		V		V			V		V
GFPT1		V		V	V			V	V		V
RIMKLB		V	V								V
ASNS									V		V
GLUD1										V
+ 00260: Glycine, serine and threonine metabolism	0.2	1	0.6	0	0.7	0.2	0.2	0.2	0.8	0.6	0.3	1.1	0.1	0.2
SHMT1	V					V				V		V	V
PHGDH		V
GRHPR		V	V		V							V
GCSH		V	V		V			V	V		V
AOC2							V			V		V
ALAS1									V
PSPH														V
+ 00270: Cysteine and methionine metabolism	0.9	2.6	0.9	0.2	0.6	0.2	0.9	0	0	1.9	0.2	0.9	0.1	0.1
AMD1	V
LDHA	V						V			V
MDH1	V			V						V				V
KYAT3		V			V		V			V		V
AHCYL1		V			V
DNMT3A		V	V
BCAT1		V	V			V	V			V	V
BCAT2		V
GCLM		V	V
PHGDH		V
MPST										V		V
KYAT1												V
MRI1													V
+ 00280: Valine, leucine and isoleucine degradation	0.1	1.8	2.3	0.6	0.6	1	0.5	1.5	0.6	0.9	2.1	0.1	1.6	0.1
ACADM	V				V						V
AUH		V	V
BCAT1		V	V			V	V			V	V
BCAT2		V
ACAA1		V				V			V
PCCB		V
MCCC1			V		V		V						V
AOX1			V							V
HIBADH			V					V
HIBCH			V								V		V
HADHB				V		V		V	V		V
ALDH3A2				V				V		V	V		V
MCCC2								V						V
HSD17B10												V
HADHA													V
HADH													V
+ 00290: Valine, leucine and isoleucine biosynthesis	0	2.5	1.4	0	0	1.4	1.4	0	0	1.4	1.4	0	0	0
BCAT1		V	V			V	V			V	V
BCAT2		V
+ 00310: Lysine degradation	1.2	0.6	0.3	1.7	0	1.2	0.4	0.8	2.3	0.7	1.8	0.1	2.5	0
DLST	V					V	V			V
EHMT2	V
SUV39H2	V		V			V			V
SETD1A	V			V		V	V						V
KMT5B		V	V							V	V
SETD7		V						V	V
PHYKPL		V											V
SETMAR				V		V
NSD2				V				V	V		V
PLOD3				V
ALDH3A2				V				V		V	V		V
EHMT1									V		V
SETDB2									V
SETD3									V				V
KMT2C											V
PLOD1												V
HADHA													V
HADH													V
ASH1L													V
PLOD2													V
+ 00220: Arginine biosynthesis	0	0.5	0	0	0	0	0.5	0	0.6	0.5	0	0.5	0	0
ASL		V					V		V			V
GLUD1										V
+ 00330: Arginine and proline metabolism	0.5	0.4	0	1	0	0.2	0.9	0.5	0.2	0.9	1.5	0.5	1.1	0.1
AMD1	V
PYCR3	V						V			V			V
PYCR1		V					V			V		V	V
ODC1		V									V
ALDH3A2				V				V		V	V		V
OAT				V		V						V
P4HA1				V				V	V		V		V
AZIN2							V				V
CKM														V
+ 00340: Histidine metabolism	0	0.4	0.5	0.5	0	0	0	0.5	0	0.5	0.5	0	0.4	0
ALDH3B1		V	V
ALDH3A2				V				V		V	V		V
+ 00350: Tyrosine metabolism	0	0.7	1.3	0	0.3	0	0.3	0.8	0.9	0.7	0.3	0.3	0.6	0
ALDH3B1		V	V
COMT		V	V		V
AOX1			V							V
AOC2							V			V		V
ADH4								V
ADH7								V
GSTZ1									V				V
MIF									V		V		V
+ 00360: Phenylalanine metabolism	0	0.6	0.6	0	0	0	0.7	0	0.7	0.7	0.7	0.7	0.5	0
ALDH3B1		V	V
AOC2							V			V		V
MIF									V		V		V
+ 00380: Tryptophan metabolism	0.2	0.2	0.2	0.2	0.2	0.2	0.6	0.7	0	1.6	0.7	0.6	1.3	0.2
DLST	V					V	V			V
KYAT3		V			V		V			V		V
AOX1			V							V
ALDH3A2				V				V		V	V		V
CYP1A1								V			V
KYAT1												V
HADH													V
HADHA													V
KYNU													V
CYP1B1														V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.6 Metabolism of other amino acids	0.7	2	2	1.1	0.3	0.7	1.9	1.1	1	2	1.5	1.8	1.9	0.1
+ 00410: beta-Alanine metabolism	0	0.7	0.8	0.3	0	0	0.3	0.9	0.4	0.8	0.9	0.3	1.2	0
ALDH3B1		V	V
ACOX1		V
HIBCH			V								V		V
ALDH3A2				V				V		V	V		V
AOC2							V			V		V
MLYCD								V	V
HADHA													V
+ 00430: Taurine and hypotaurine metabolism	0	0.8	0	0	0	0	0	0	0	0	0	0	0	0
GGT5		V
+ 00440: Phosphonate and phosphinate metabolism	0	0	0	0	0	0	2.2	0	0	1.2	0	1.2	1.1	0
CEPT1							V			V		V
PCYT2							V
CHPT1													V
+ 00450: Selenocompound metabolism	0.6	1.3	2.1	0.7	0.7	0.6	2.1	0.7	2.3	1.4	2.2	2.1	1.9	0
SEPHS1	V		V						V		V		V
KYAT3		V			V		V			V		V
SCLY		V	V					V	V		V
TXNRD2			V				V			V		V	V
TXNRD1				V		V	V
MARS									V		V		V
KYAT1												V
+ 00471: D-Glutamine and D-glutamate metabolism	0	0	0	0	0	0	0	0	0	1.3	0	0	0	0
GLUD1										V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00480: Glutathione metabolism	1.2	2.4	2.5	1.8	0.1	1.2	0.4	1.3	0.1	0.8	0.9	1.2	0.9	0.4
TXNDC12	V			V		V		V			V			V
GSTM1	V			V								V
GSTO1	V			V		V								V
RRM2	V			V		V		V			V		V
GGT5		V
GPX1		V	V
GCLM		V	V
MGST2		V	V		V					V		V
PGD		V
ODC1		V									V
RRM2B		V	V
IDH1			V
GSTM4			V										V
GSR			V					V	V
GSTT2B				V		V	V			V		V
NAT8							V			V
G6PD								V					V
GPX8												V
MGST1													V
+ 1.7 Glycan biosynthesis and metabolism	1.8	2.8	2.6	1.3	3	1.6	1.7	2.3	1.3	2.5	1.9	2.4	1.5	3.1
+ 00510: N-Glycan biosynthesis	0.9	0.8	0.9	0.2	0.6	0.5	0.9	0.2	0.6	0.9	0.6	0.9	1.6	0.9
MAN2A2	V					V	V					V	V
RPN2	V			V					V					V
TUSC3	V						V				V		V
B4GALT3		V			V
B4GALT2		V												V
DDOST		V	V		V		V			V		V	V
MGAT5B			V
ALG8			V						V		V
B4GALT1						V				V
DPM1								V		V		V		V
FUT8													V
ST6GAL1													V
+ 00512: Mucin type O-glycan biosynthesis	0	0.3	0.3	0	0	0	0.3	0	0	1.5	0	0.3	0.2	0.9
GALNT2		V	V				V							V
POC1B-GALNT4										V
GALNT4										V
GALNT11										V
ST3GAL1												V
GALNT3													V
GALNT14														V
+ 00515: Mannose type O-glycan biosynthesis	0.5	2.9	2.4	0.5	2.6	0.5	1.1	0.5	0.5	1.1	1.2	0.5	0.9	1.1
FKTN	V		V		V		V
B4GALT3		V			V
B4GALT2		V												V
POMT1		V	V		V						V			V
B3GALNT2		V					V			V		V	V
FKRP		V						V	V		V
POMGNT1			V		V								V
MGAT5B			V
FUT4				V
B4GALT1						V				V
+ 00514: Other types of O-glycan biosynthesis	1.1	1.7	0.5	1.2	1.3	0.5	0	0.5	0.6	0.5	1.2	0	0.4	1.8
POFUT2	V			V
POGLUT1	V													V
B4GALT3		V			V
B4GALT2		V												V
POMT1		V	V		V						V			V
PLOD3				V
B4GALT1						V				V
GXYLT1								V	V		V
ST6GAL1													V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1.3	0	0.6	0.6	0.6	0.6	0	2.1	1.4	0	1.4	0	0	0.6
B3GAT3	V		V		V			V	V		V
DSE	V
CHST15				V
XYLT2						V
CHSY1								V						V
CHST11								V	V		V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.5	0.4	1.1	0.5	0.6	1.2	0.5	2.6	0.6	0	1.9	0	0	1.8
B3GAT3	V		V		V			V	V		V
EXTL3		V	V				V
EXT2				V				V			V			V
XYLT2						V
NDST1						V		V			V
HS3ST3B1								V						V
GLCE														V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	1.5	0	0	0.8	0.7	0	0	0	0.7	0	0.7	0.6	0.7
B4GALT3		V			V
B4GALT2		V												V
B4GALT1						V				V
ST3GAL1												V
FUT8													V
+ 00531: Glycosaminoglycan degradation	0.6	0	1.3	1.4	1.4	0.6	1.3	1.4	0	1.3	0	2	0.5	1.3
HPSE	V			V	V								V
GLB1			V		V					V		V
GUSB			V
HYAL1				V
IDUA						V
GALNS							V			V		V
ARSB							V					V
SPAM1								V						V
HYAL3								V						V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	1.7	0.5	0	1.2	0	0.5	0.5	0.5	0	0.5	0	0.4	0.5
PIGX		V
PIGT		V	V		V			V	V		V			V
PIGV		V
PIGG					V								V
PIGO							V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0.4	0.9	0	0.4	0.5	1	0	0.5	0.5	0.4	0	0	0.3	0.4
ST3GAL4	V					V		V	V
B4GALT3		V			V
B4GALT2		V												V
FUT4				V
B4GALT1						V				V
ST3GAL6													V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0	0	0	0	0.7	0	0	0.7	0	0.7	0	0
GLA							V			V
ST3GAL1												V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0	0	0.7	0	0.8	0	0	0	0	0.7	0	1.5	0.6	0.7
GLB1			V		V					V		V
ST3GAL1												V
ST3GAL5													V
ST6GALNAC4														V
+ 00511: Other glycan degradation	1.3	0	1.3	0	0.7	0	0.6	0	0	1.3	0	2	0	0.6
MAN2B1	V
GBA	V		V				V			V		V		V
GLB1			V		V					V		V
MANBA												V
+ 1.8 Metabolism of cofactors and vitamins	1.5	2.2	2.6	0.4	2.1	2.6	1.1	1.5	1.1	2.7	1.6	1.1	1.8	0.8
+ 00730: Thiamine metabolism	0.7	1.4	2.2	0.7	2.4	0.7	0.7	2.3	0.8	1.5	3.1	0.7	0.6	0.7
AK5	V					V		V	V		V			V
ALPP		V
ACP1		V	V		V
AK2			V		V			V			V
NFS1			V		V		V			V		V
AK4				V				V		V	V		V
THTPA											V
+ 00740: Riboflavin metabolism	0	1.9	1	0	1.1	1.1	0	0	0	0	0	0	0	0
ACP1		V	V		V
ACP2		V				V
+ 00750: Vitamin B6 metabolism	1.2	0	1.2	0	1.3	0	0	0	0	1.2	0	0	1.1	0
PNPO	V				V								V
AOX1			V							V
+ 00760: Nicotinate and nicotinamide metabolism	0.9	0.8	1.4	0	0	0.3	0.9	0.4	0.4	2.6	0.4	0.9	1.8	0.3
NADSYN1	V					V			V
NADK2	V		V					V		V	V		V
NAPRT		V								V		V	V
NT5C		V
NAMPT			V				V			V			V
AOX1			V							V
NT5C3A							V			V
NT5C3B												V		V
NADK													V
+ 00770: Pantothenate and CoA biosynthesis	0	1.2	0.6	0	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0	0	0
BCAT1		V	V			V	V			V	V
BCAT2		V
PANK2					V			V	V
+ 00780: Biotin metabolism	0	0	0	0	0	1.5	0	0	0	0	0	0	0	0
HLCS						V
+ 00785: Lipoic acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00790: Folate biosynthesis	0.4	1	0	0	0.5	0.4	0.4	0.5	0.5	1	0	0.4	0	0.4
DHFR	V					V	V			V		V		V
ALPP		V
CBR1		V			V			V		V
MOCS2									V
+ 00670: One carbon pool by folate	1.2	0.5	0.5	0.6	0.6	2.6	1.3	0.6	0.6	1.2	0	1.2	1.1	1.2
DHFR	V					V	V			V		V		V
SHMT1	V					V				V		V	V
GART		V	V		V			V	V					V
ATIC				V		V
MTHFD1						V	V						V
+ 00830: Retinol metabolism	0	0	0.1	0	0.1	0	0	0.7	0	0.3	0.1	0	0	0.1
AOX1			V							V
DGAT1					V					V				V
ADH4								V
ADH7								V
CYP1A1								V			V
RDH11													V
+ 00860: Porphyrin and chlorophyll metabolism	0	1	1.1	0.2	0.7	0	0	0	0.7	0	0.2	0.6	0	0
ALAD		V	V		V				V		V
COX15		V
HMOX2		V	V		V							V
GUSB			V
UROS				V								V
ALAS1									V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0.9	0	0.9	0	0	1.9	0	0	0	0.9	1	0	1.7	0
COQ5	V					V					V		V
NQO1			V										V
VKORC1L1						V
COQ7										V
+ 1.9 Metabolism of terpenoids and polyketides	0	0.4	0.5	0	0.5	0.5	0.5	0	1.2	0	0.5	0	1.5	0
+ 00900: Terpenoid backbone biosynthesis	0	0.4	0.5	0	0.5	0.5	0.5	0	1.2	0	0.5	0	1.5	0
DHDDS		V	V			V			V
HMGCR					V
FDPS							V						V
MVK									V				V
ICMT											V		V
+ 1.10 Biosynthesis of other secondary metabolites	0	0	0	0.9	0	0.9	0	0	0	0	0	0	0	0.9
+ 00232: Caffeine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	1.3
NAT1														V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	0	1.3	0	1.3	0	0	0	0	0	0	0	0
GCK				V		V
+ 1.11 Xenobiotics biodegradation and metabolism	1	0.9	2.3	1.8	0.5	0.9	0.7	1.2	0.2	1.7	0.7	1.2	0.9	1
+ 00980: Metabolism of xenobiotics by cytochrome P450	0.5	0.7	0.4	0.9	0.3	0.2	0	0.9	0.1	0.5	0.3	0.5	0.3	0.5
GSTM1	V			V								V
GSTO1	V			V		V								V
AKR7A2	V
MGST2		V	V		V					V		V
ALDH3B1		V	V
EPHX1		V							V		V
CBR1		V			V			V		V
GSTM4			V										V
GSTT2B				V		V	V			V		V
AKR1C1				V									V
ADH4								V
ADH7								V
CYP1A1								V			V
MGST1													V
CYP2E1														V
CYP1B1														V
+ 00982: Drug metabolism - cytochrome P450	0.2	0.2	0.9	0.6	0.1	0.2	0.1	0.3	0	0.5	0	0.5	0.1	0.2
GSTM1	V			V								V
GSTO1	V			V		V								V
ALDH3B1		V	V
MGST2		V	V		V					V		V
GSTM4			V										V
AOX1			V							V
GSTT2B				V		V	V			V		V
ADH4								V
ADH7								V
MGST1													V
CYP2E1														V
+ 00983: Drug metabolism - other enzymes	1.1	0.6	2.6	1.7	0.5	1.2	1.2	0.9	0.2	1.9	0.9	1.1	1.2	1.1
UCKL1	V					V	V			V		V	V
NME2	V								V		V
RRM2	V			V		V		V			V		V
GSTM1	V			V								V
GSTO1	V			V		V								V
UCK1		V	V							V				V
NME7		V	V					V					V
RRM2B		V	V
MGST2		V	V		V					V		V
ITPA			V		V		V			V
TYMP			V
GUSB			V
NME6			V											V
GSTM4			V										V
UMPS				V		V		V
IMPDH1				V	V					V
GSTT2B				V		V	V			V		V
UPP1							V			V			V
DUT							V
UCK2								V			V
CES1									V		V
CMPK1												V
MGST1													V
NAT1														V
CYP2E1														V
+ 2. Genetic Information Processing	6.8	6.6	7.1	6.9	9.7	6	7	7.1	7.1	6.6	5.9	6.7	6.5	8
+ 2.1 Transcription	4.6	1.4	1.8	3	5.3	3.9	3.1	2.4	2.5	3	2.4	3.4	2.9	3.1
+ 03020: RNA polymerase	1.4	0.8	0.3	1.5	2.2	0.9	0.9	0.9	1.6	1.4	0.9	2	0.7	1.4
POLR2B	V				V							V
POLR2J2	V			V		V			V		V			V
POLR2J3	V			V		V			V		V			V
POLR3H		V	V									V
POLR1B		V			V			V		V		V
POLR2H				V	V								V
POLR2E					V		V			V		V		V
POLR1D							V			V			V
POLR3B								V	V
+ 03022: Basal transcription factors	3.4	0.9	1	1.6	2.7	4.3	1	2.1	1.2	2.9	2.7	2.9	0.8	2
TAF1	V			V		V				V		V
TAF9	V					V		V	V		V
GTF2H2	V			V		V
GTF2H2C	V		V			V		V		V	V		V
GTF2H2C_2	V					V		V		V	V			V
GTF2H4	V			V			V			V		V		V
TAF15	V			V		V					V
CDK7	V					V							V
GTF2I		V	V							V		V		V
GTF2H1		V			V					V
ERCC3		V			V
ERCC2			V		V
GTF2F2					V									V
GTF2H3					V			V	V		V
MNAT1					V
TAF4						V						V
TAF6						V					V
GTF2A2						V
TAF4B							V					V
CCNH							V			V		V	V
GTF2A1								V	V			V		V
+ 03040: Spliceosome	3.1	0.7	1.8	2	4.3	1.6	3.4	1.1	1.5	0.9	0.5	0.9	3.7	1.8
DDX39B	V			V
DHX8	V			V		V	V			V
SNRPD3	V								V
SNRPG	V				V								V
PUF60	V			V	V								V
CHERP	V						V							V
HNRNPA1L2	V			V									V
TRA2A	V		V		V		V							V
SRSF1	V					V			V				V
HSPA1B	V			V		V	V			V				V
PQBP1	V			V		V	V			V		V	V
ISY1-RAB43	V			V		V
ISY1	V			V		V
LSM6	V											V
DDX46		V	V		V			V					V
HNRNPM		V			V					V			V
SRSF10		V	V		V							V
SRSF6		V	V
HSPA1A		V												V
XAB2		V			V			V						V
LSM2		V	V		V		V						V
SNRPD2			V				V			V		V
DDX42			V		V				V
TXNL4A			V		V		V					V	V
EIF4A3			V
PRPF18			V		V			V						V
SNRPB				V									V
SF3B3				V		V		V
SF3A2					V								V
PLRG1					V
SYF2					V								V
EFTUD2					V				V		V		V
USP39					V				V		V
ZMAT2					V								V
U2AF1						V	V						V
RBMX						V
PRPF40A							V
U2AF2							V						V
RBM17							V			V		V	V
RBM22							V
PPIH							V
RBM8A							V						V
SF3B1								V
NCBP1								V	V		V
PPIE								V						V
DHX16									V
PRPF8									V		V
SF3B4										V		V		V
SNRNP200											V			V
PRPF38B														V
+ 2.2 Translation	2.9	2.5	3.8	3.3	3.6	1.7	3.2	3.5	3.9	3.3	2.8	4.2	2.3	4.7
+ 03010: Ribosome	1.8	1	1.5	1.1	2.8	1	0.7	2.7	1.5	1.5	0.5	1.8	2.5	1.5
RPS17	V			V	V		V
RPS24	V			V		V		V			V			V
RPS27	V
RPL23	V		V		V					V		V	V
RPL17	V		V		V			V		V		V	V
MRPL23	V		V		V					V		V	V
RPL15	V			V		V		V	V			V		V
RPL10	V					V		V	V			V		V
MRPL4	V			V		V
RPLP1	V							V					V
RPL28		V				V						V
MRPL11		V						V						V
RPL11		V	V		V		V			V		V	V
RPL17-C18orf32		V			V			V		V	V		V
UBA52		V	V		V			V	V				V
RPL37		V			V			V	V		V
RPSA		V	V		V							V
MRPS2		V	V		V									V
RPS20			V				V			V		V	V
MRPS18C			V		V				V
RPS10-NUDT3				V		V	V
MRPL10				V		V
RPL4				V				V	V		V
RPL9					V			V						V
RPL41							V					V	V
MRPL1							V						V
RPL21								V	V		V			V
RPS18									V
RPL8										V
RPL32										V			V
RPS2										V				V
RPL34													V
RPL14													V
MRPS14													V
RPS10														V
+ 00970: Aminoacyl-tRNA biosynthesis	0.6	0.9	1.5	0.6	1.7	0	0.6	0.6	1.2	0	1.7	1	0.4	0.6
CARS	V			V					V		V
LARS	V		V		V						V
HARS		V	V		V		V						V
GARS		V	V		V			V						V
YARS2		V
FARSB			V		V
VARS				V			V					V
TARS								V				V		V
MARS									V		V		V
WARS									V		V
GATB												V
+ 03013: RNA transport	2.9	1.2	1.4	4	1.4	2.1	3.8	1	2.7	2.8	2	3.7	0.7	3.7
CLNS1A	V			V		V		V	V				V
SMN2	V			V	V		V			V		V	V
SRRM1	V											V		V
NUP58	V									V		V
SENP2	V			V					V		V
NUP98	V									V				V
SUMO1	V			V	V				V		V
PRMT5	V			V		V				V
DDX39B	V			V
EIF3CL	V			V	V		V					V	V
EIF3C	V			V		V	V					V		V
PABPC1	V					V			V			V
EIF4B	V											V		V
EIF2B3	V					V	V			V			V
CYFIP1	V			V		V	V					V	V
SMN1		V	V			V	V			V	V			V
GEMIN7		V	V		V		V						V
NUP205		V					V					V		V
NUP155		V	V		V									V
RANGAP1		V
RPP38		V	V		V
THOC7		V		V		V	V							V
EIF4A1		V			V			V						V
EIF4G1		V	V		V		V			V		V
FXR1		V					V			V		V	V
EIF4A3			V
NDC1			V							V	V			V
SUMO2			V						V
RPP40			V
EIF4G3			V
GEMIN4				V					V					V
NUP50				V			V					V
POM121				V				V	V		V
NUP214				V			V					V
EIF1AX				V
EIF2S2				V	V			V	V		V			V
EIF4E				V		V
EIF5				V		V		V	V		V			V
NUP62						V								V
SEC13						V	V			V		V
RBM8A							V						V
UPF1							V					V
RPP21							V			V		V
CYFIP2							V					V
NCBP1								V	V		V
RPP30								V	V		V		V
ELAC2								V			V
SUMO3									V
UPF3A									V
KPNB1										V
NUP107										V
NUP88										V
PYM1										V
EIF4G2											V			V
EIF2B1												V
RNPS1														V
NUP210														V
UPF3B														V
+ 03015: mRNA surveillance pathway	0.6	1.8	3.1	1.4	1.9	0.3	1.3	1.5	1.2	0.3	0.7	1.7	1	2.8
SRRM1	V											V		V
DDX39B	V			V
PABPC1	V					V			V			V
PELO	V			V		V
SMG1		V	V		V		V						V
ETF1		V		V	V			V	V					V
CPSF7		V		V	V			V	V		V
CSTF3		V			V								V
SYMPK		V	V		V
PPP2R5C		V	V		V		V							V
PPP2R5E		V	V		V									V
HBS1L		V	V				V			V		V		V
EIF4A3			V
RNMT			V			V					V
PPP2R3B			V
PPP2R1A			V							V		V	V
DAZAP1			V
PPP1CB			V
CSTF1				V								V	V
CSTF2				V										V
RBM8A							V						V
UPF1							V					V
SMG7							V
NCBP1								V	V		V
PCF11								V
CPSF1								V					V
PPP1CA								V			V
UPF3A									V
PYM1										V
PPP2R3A												V
RNPS1														V
UPF3B														V
PPP2R2D														V
MSI2														V
+ 03008: Ribosome biogenesis in eukaryotes	0.8	0.6	1.1	0.2	0.2	0.5	0.8	2.1	2.2	2.7	1.3	1.1	0.5	1.9
GNL3L	V
CSNK2A1	V							V	V					V
CSNK2A2	V							V	V					V
AK6	V					V		V	V		V			V
TCOF1		V						V			V
FCF1		V							V					V
RPP38		V	V		V
EIF6		V					V			V
NHP2			V				V			V
DKC1			V					V	V		V			V
RPP40			V
CSNK2B			V				V			V		V	V
BMS1				V		V				V	V
REXO1				V		V
HEATR1					V					V		V
NOP56							V			V		V		V
RPP30								V	V		V		V
XRN2								V	V					V
DROSHA										V
IMP3										V
SPATA5										V		V
RRP7A												V
CSNK2A3													V
EFL1													V
+ 2.3 Folding, sorting and degradation	3.3	3.7	4.9	4	3.7	3.5	3.2	4.6	3.2	3.6	3.5	3.5	3	4.5
+ 03060: Protein export	1.1	0	0	0.5	0	0	0	1.9	0.5	1.1	1.9	0.5	0.4	1.8
SRP54	V									V		V		V
SEC61A2	V			V							V
SRP72								V	V		V			V
SRPRA								V					V
SEC11A								V		V	V
SRP68														V
+ 04141: Protein processing in endoplasmic reticulum	2.8	2	3.6	3.6	2	2.3	2.3	2.2	3.2	2.8	3.4	2.5	2.2	3.4
MAPK8	V			V				V			V
MAP3K5	V
MAP2K7	V			V		V
CANX	V			V			V
SEC61A2	V			V							V
RPN2	V			V					V					V
TUSC3	V						V				V		V
EIF2AK1	V		V						V		V
EIF2AK2	V		V						V		V			V
HSPA1B	V			V		V	V			V				V
PDIA6	V
RNF185	V			V		V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
NFE2L2	V			V		V				V
DDOST		V	V		V		V			V		V	V
PRKCSH		V	V		V		V			V		V	V
ATF6B		V	V		V		V			V		V		V
RAD23B		V		V					V
HSPA1A		V												V
OS9		V	V		V		V						V
ERLEC1		V
UBE2D3		V	V		V			V						V
DNAJC5		V										V	V
DNAJC10		V				V	V			V		V
SEC31A		V	V											V
HSPA4L		V	V		V			V		V		V
HSPBP1		V			V			V			V			V
CAPN1			V							V	V
EDEM2			V		V							V	V
MARCH6			V		V				V		V
UBE2G2			V					V	V
BAX			V					V		V		V
ATF6			V										V
UBQLN4			V										V
HYOU1			V								V		V
SSR3			V			V			V					V
TRAF2				V
SEC24A				V										V
UBE2G1				V		V		V						V
UBE4B				V								V
SAR1B				V		V					V
BCAP31				V		V			V		V		V
MAPK9					V									V
HSPH1					V		V			V		V	V
CAPN2						V	V			V	V		V
SEC13						V	V			V		V
SSR1						V	V		V			V	V
VCP								V	V		V		V
SEC23B								V	V		V			V
SEC24C								V	V		V
ERO1A								V
NGLY1									V
TRAM1									V
DNAJC1										V
SIL1										V
NSFL1C												V	V
SYVN1														V
UBQLN1														V
+ 04130: SNARE interactions in vesicular transport	0.8	1.8	1.3	2.5	2.1	0.3	0.3	0.9	0.3	0.8	0.3	0.8	0.2	3
STX16	V							V	V		V			V
VAMP7	V			V										V
STX6		V								V		V
VTI1B		V	V		V							V		V
STX1A		V	V
VAMP2		V	V		V
USE1				V	V
BET1				V						V
SNAP23				V										V
STX3				V
STX2					V			V						V
STX4						V							V
STX8							V							V
+ 04120: Ubiquitin mediated proteolysis	1.5	4.2	3.6	2	2.1	3.7	1.8	5	1.5	1.2	2	2.1	2.2	2.7
SOCS1	V					V
ANAPC11	V			V		V		V		V		V	V
CUL3	V									V			V
BIRC2	V
SMURF2	V			V		V							V
UBE2L3	V			V		V		V
TRIP12	V
NEDD4L	V			V		V
UBE2O	V			V		V							V
DDB2		V			V						V
HERC4		V	V			V	V			V		V	V
HERC3		V			V			V
CDC16		V						V	V				V
CDC27		V						V						V
FZR1		V
ANAPC2		V
TRIM37		V											V
MID1		V	V		V		V			V		V	V
MGRN1		V							V		V
PIAS1		V				V	V					V
PML		V	V		V			V				V	V
SIAH1		V			V				V		V
UBE2D3		V	V		V			V						V
UBE2C		V
ITCH		V	V		V			V						V
UBE2K		V	V					V	V		V			V
UBA7		V	V		V			V	V
UBE2H		V	V					V		V	V			V
FBXW11			V					V						V
CUL2			V
BRCA1			V		V			V			V
BIRC3			V
UBE3A			V
UBE2A			V							V				V
UBE2G2			V					V	V
UBE2E2			V					V			V
CUL4A				V		V					V		V
UBE2G1				V		V		V						V
UBE4B				V								V
UBE2Z				V	V
NEDD4				V		V			V			V		V
SKP2						V		V			V			V
VHL						V	V					V	V
UBE2F						V	V
XIAP						V						V
UBA6						V
ELOB							V			V		V
BTRC							V
UBA3							V
ANAPC5							V
ANAPC4							V			V		V	V
SAE1								V
WWP2								V	V				V
BIRC6								V
UBE2B											V
RHOBTB2														V
SYVN1														V
HUWE1														V
+ 04122: Sulfur relay system	0	0	1	0	1.1	0	1	0	1.1	2	0	2	0	0
NFS1			V		V		V			V		V
MOCS2									V
MPST										V		V
+ 03050: Proteasome	1	0.5	0.5	0.6	1.7	0.6	1	0.6	0.7	1	0.2	0.2	0.8	0.5
PSME3	V						V			V		V	V
PSMA6	V										V
PSMB5	V			V						V
PSMA5		V			V		V						V
PSMB3		V	V											V
PSMA4			V		V		V
PSMC1				V
PSMA3					V
PSMB8					V
SEM1						V		V	V					V
PSMB2						V				V
PSMB6								V
PSMD2									V
PSMA1													V
+ 03018: RNA degradation	1.5	1.4	3.1	1.3	0.9	2.4	2	1.7	1	0.8	1.3	1.2	2.3	0.4
EXOSC7	V									V
TTC37	V			V		V	V
EXOSC10	V			V		V							V
LSM6	V											V
PABPC1	V					V			V			V
PFKM	V		V			V	V				V			V
EXOSC6		V						V	V
MPHOSPH6		V			V		V					V
CNOT10		V			V		V						V
LSM2		V	V		V		V						V
DDX6		V	V
DHX36		V						V			V		V
WDR61			V					V			V
DIS3			V										V
CNOT1			V											V
DCP2			V
PARN			V			V	V			V		V	V
TOB1			V
BTG3			V		V
TENT4A				V		V		V					V
CNOT4				V		V		V
BTG1				V			V			V		V
CNOT6L						V
XRN2								V	V					V
DIS3L									V		V
ENO2										V
DCP1A											V
ENO1													V
CNOT2													V
+ 2.4 Replication and repair	2.7	5.6	3.7	3.5	6.8	2.9	4.4	3.7	4.5	3.2	3.1	2.2	4.8	3.6
+ 03030: DNA replication	0.7	4.1	2.8	1.9	3.6	1.3	2.9	0.8	2.6	0.7	1.4	1.8	3.5	2.3
MCM4	V			V									V
PRIM1	V													V
LIG1		V			V		V
RFC2		V		V			V						V
POLD3		V			V								V
POLE3		V		V	V				V		V			V
RNASEH1		V	V		V		V		V		V		V
MCM2		V	V						V
POLA1		V	V		V		V			V		V	V
POLE		V			V			V						V
RPA2		V			V			V	V
RNASEH2B			V							V		V	V
RFC5			V
SSBP1			V			V	V		V		V
MCM3				V			V							V
POLE2						V							V
MCM7						V						V	V
RFC3												V
POLD1														V
+ 03410: Base excision repair	0	2.3	0	1.5	3.2	1.4	1.4	0.9	0.9	1.4	0.9	0	2.2	1.9
LIG1		V			V		V
POLE3		V		V	V				V		V			V
POLE		V			V			V						V
POLD3		V			V								V
MBD4		V							V				V
NTHL1				V		V
HMGB1				V				V
PARP3					V
OGG1					V		V			V			V
POLE2						V							V
MPG						V	V			V
LIG3										V
PARP2											V
MUTYH													V
POLD1														V
POLL														V
+ 03420: Nucleotide excision repair	2.4	4.4	0.9	2.5	4.9	2.5	2	2.1	2.2	1.9	2.6	1	2.5	1.9
GTF2H4	V			V			V			V		V		V
GTF2H2	V			V		V
GTF2H2C	V		V			V		V		V	V		V
GTF2H2C_2	V					V		V		V	V			V
CDK7	V					V							V
XPA	V						V
GTF2H1		V			V					V
ERCC3		V			V
LIG1		V			V		V
RFC2		V		V			V						V
POLE3		V		V	V				V		V			V
POLE		V			V			V						V
POLD3		V			V								V
RPA2		V			V			V	V
ERCC1		V							V
DDB2		V			V						V
RAD23B		V		V					V
ERCC2			V		V
RFC5			V
CUL4A				V		V					V		V
GTF2H3					V			V	V		V
MNAT1					V
POLE2						V							V
CCNH							V			V		V	V
RFC3												V
POLD1														V
+ 03430: Mismatch repair	1.1	2.3	2.4	0.5	1.9	0.5	1.8	1.2	1.2	0.5	0.5	0.5	1.5	0.5
MLH1	V												V
MSH6	V		V							V
LIG1		V			V		V
POLD3		V			V								V
RPA2		V			V			V	V
RFC2		V		V			V						V
EXO1			V					V
RFC5			V
SSBP1			V			V	V		V		V
RFC3												V
POLD1														V
+ 03440: Homologous recombination	0.6	1	1.6	1.2	1.8	1.1	1.1	1.8	1.8	1.6	0.7	1.1	0.9	2.1
MRE11	V			V
RAD54B	V					V	V
TOP3A		V	V
RPA2		V			V			V	V
POLD3		V			V								V
RAD51C			V
SSBP1			V			V	V		V		V
BRCA1			V		V			V			V
RAD51D				V
RBBP8				V						V		V		V
RAD51					V		V			V
SEM1						V		V	V					V
BABAM2								V	V				V
PALB2										V
ATM										V		V		V
BRCC3												V		V
BLM													V
POLD1														V
+ 03450: Non-homologous end-joining	1.6	0	0.8	0.8	1.7	0.8	0.8	1.7	1.7	0.8	1.7	0.8	0.7	0.8
MRE11	V			V
XRCC6	V					V				V
POLM			V		V				V
XRCC4					V			V	V		V
XRCC5							V					V	V
LIG4								V			V
POLL														V
+ 03460: Fanconi anemia pathway	0.8	0.7	1.2	0.9	0.9	0.1	1.7	1.4	1.5	1.7	0.5	0.8	1.4	0
FANCA	V
MLH1	V												V
REV3L	V								V				V
TOP3A		V	V
RPA2		V			V			V	V
ERCC1		V							V
BRCA1			V		V			V			V
RAD51C			V
POLH			V
RMI1				V			V
UBE2T				V
POLK				V		V		V					V
RAD51					V		V			V
FANCD2							V			V		V	V
FANCI							V					V
POLI							V
CENPX								V	V		V
PALB2										V
CENPS-CORT										V
CENPS										V
FAN1												V
BLM													V
+ 3. Environmental Information Processing	5.5	3.2	2.6	4.7	2	5	3.2	3.2	2.8	2.8	3.5	2.3	3.6	5.1
+ 3.1 Membrane transport	0.5	0.9	0.2	1.6	0	1.5	0.6	1.1	1.2	0.2	0.6	1	0.4	0
+ 02010: ABC transporters	0.5	0.9	0.2	1.6	0	1.5	0.6	1.1	1.2	0.2	0.6	1	0.4	0
ABCC1	V			V		V			V				V
TAP2	V			V		V	V		V			V
ABCC10		V					V					V	V
ABCC4		V						V
ABCB9		V	V
ABCB7				V		V					V
ABCB8				V		V				V		V
ABCC3								V	V		V
ABCA7								V
+ 3.2 Signal transduction	7.1	4.1	4	5.8	3.3	6	4.8	4.1	3.5	4.3	5.4	2.5	5.7	7.5
+ 04010: MAPK signaling pathway	2.8	0.8	1.2	1.7	0.7	2.2	2.4	1.1	1	1.4	0.7	0.8	1.6	2.4
MAP4K4	V					V			V				V
NFKB1	V				V				V
NFKB2	V			V										V
NF1	V			V		V	V					V
NRAS	V					V
EGFR	V					V		V	V		V
MAP2K5	V			V										V
CDC25B	V							V		V				V
MAX	V			V				V	V			V		V
TP53	V		V									V		V
PPP5C	V			V		V						V		V
MAP3K5	V
IL1A	V
IL1B	V												V
MAP2K7	V			V		V
MAPK8	V			V				V			V
CRK	V		V		V		V			V				V
HSPA1B	V			V		V	V			V				V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
FLNB	V			V		V				V
CSF1	V			V				V		V		V	V
MYD88	V					V			V					V
IKBKG		V	V		V		V							V
MAP3K14		V	V					V
PRKACB		V		V	V								V
ERBB2		V					V			V		V		V
FGFR1		V
PPM1A		V	V		V
TAOK1		V	V		V		V			V		V	V
MAP3K7		V	V											V
MAP3K13		V	V		V					V		V
IL1RAP		V										V	V
HSPA1A		V												V
FLNC		V												V
RPS6KA1		V
VEGFA		V			V
IRAK1		V		V		V			V
DUSP4			V					V	V				V
STMN1			V				V			V
IKBKB			V		V		V						V
MET			V			V					V
CACNB1			V										V
CASP3			V					V			V
IL1R1			V
MAP3K3			V					V						V
HRAS				V			V			V		V		V
ATF2				V		V	V						V
DAXX				V			V			V				V
TRAF2				V
RAP1A					V		V			V			V
TAOK2					V			V	V
MAPK9					V									V
RPS6KA4						V
MAP4K2						V
MECOM						V	V			V		V	V
PDGFA						V
TGFA						V	V						V
ARAF						V
CHUK							V
NLK							V			V		V
MAPK14							V
TAOK3							V			V		V
STK3							V
ARRB1							V					V
PPP3CC							V			V				V
DUSP10								V	V		V
NR4A1								V	V		V
ECSIT								V	V		V			V
ARRB2								V	V		V
SOS2									V				V
MAPK12											V		V
PAK1											V
MAPK8IP3											V
ELK1													V
AKT3													V
RAC1													V
RAC3													V
PDGFD													V
MKNK2														V
+ 04012: ErbB signaling pathway	2.5	1.2	0.1	2.7	0.2	2.2	1.8	0.2	0.2	1.8	0.8	0.7	1	2.1
STAT5A	V			V										V
EGFR	V					V		V	V		V
GSK3B	V			V
MAP2K7	V			V		V
MAPK8	V			V				V			V
CRK	V		V		V		V			V				V
SHC1	V			V									V
ABL1	V			V		V	V			V		V		V
NRAS	V					V
ERBB2		V					V			V		V		V
PAK4		V					V						V
BUB1B-PAK6		V
PAK6		V
ABL2		V
PIK3R2		V
NRG1			V
RPS6KB1				V		V				V
PLCG1				V
HRAS				V			V			V		V		V
MAPK9					V									V
STAT5B						V
TGFA						V	V						V
ARAF						V
PTK2							V			V		V		V
SOS2									V				V
MTOR										V
PAK1											V
PIK3CA											V
ELK1													V
AKT3													V
CDKN1A														V
+ 04014: Ras signaling pathway	1	0.8	0.1	1.2	0.4	1.6	1.5	0	0.5	0.1	0.6	0	2	0.6
NRAS	V					V
SHC1	V			V									V
CSF1	V			V				V		V		V	V
EGFR	V					V		V	V		V
PTPN11	V			V		V			V
RGL2	V		V			V	V			V	V		V
ABL1	V			V		V	V			V		V		V
NFKB1	V				V				V
MAPK8	V			V				V			V
ETS1	V			V		V			V		V
RAB5C	V					V	V					V		V
NF1	V			V		V	V					V
PIK3R2		V
VEGFA		V			V
FGFR1		V
RALGDS		V	V
ABL2		V
IKBKG		V	V		V		V							V
RHOA		V	V				V		V		V			V
CALM2		V	V		V		V		V		V		V
PAK4		V					V						V
BUB1B-PAK6		V
PAK6		V
PRKACB		V		V	V								V
MET			V			V					V
IKBKB			V		V		V						V
HRAS				V			V			V		V		V
BCL2L1				V		V								V
RAB5B				V						V			V
PLCG1				V
MAPK9					V									V
RAP1A					V		V			V			V
PDGFA						V
TGFA						V	V						V
PLAAT3						V							V
ARF6						V								V
CHUK							V
RASSF5							V						V
GAB2								V
SOS2									V				V
AFDN									V
PIK3CA											V
PAK1											V
AKT3													V
PDGFD													V
RAC1													V
RAC3													V
ELK1													V
GNB1													V
GNG10														V
GNB4														V
+ 04015: Rap1 signaling pathway	1	0.4	0.2	0.3	0.2	0.8	1.1	0.2	0.4	0.2	0.8	0	1.7	0.6
CSF1	V			V				V		V		V	V
EGFR	V					V		V	V		V
ITGB1	V			V		V					V			V
GNAS	V						V						V
CRK	V		V		V		V			V				V
PRKD2	V			V				V	V				V
KRIT1	V
GNAI2	V			V		V		V
NRAS	V					V
CTNND1	V			V		V		V	V					V
PARD6B	V					V
VEGFA		V			V
FGFR1		V
RALGDS		V	V
ADORA2A		V
LPAR2		V
RHOA		V	V				V		V		V			V
PIK3R2		V
CALM2		V	V		V		V		V		V		V
BCAR1		V							V				V
MET			V			V					V
F2R			V
SIPA1L3			V		V
HRAS				V			V			V		V		V
PLCG1				V
RAP1A					V		V			V			V
PLCB3					V						V		V
PDGFA						V
ENAH						V	V			V				V
ADCY7						V								V
RASSF5							V						V
MAPK14							V
PFN1							V					V
LPAR1							V			V
GNAI3								V			V
AFDN									V
PRKD3										V		V
MAPK12											V		V
PIK3CA											V
PDGFD													V
RAC1													V
RAC3													V
ADORA2B													V
MAGI1													V
AKT3													V
ID1													V
ITGB2														V
THBS1														V
+ 04310: Wnt signaling pathway	2.8	1.4	1.3	1.9	1.1	1.8	1.7	2.2	2.1	1.4	3.2	0.8	1.7	2.9
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
FZD6	V			V		V		V			V		V
WNT5B	V			V		V
MAPK8	V			V				V			V
PRICKLE3	V					V	V						V
CCND3	V			V		V	V			V	V			V
CREBBP	V					V		V			V		V
TP53	V		V									V		V
GSK3B	V			V
SENP2	V			V					V		V
CSNK2A1	V							V	V					V
CSNK2A2	V							V	V					V
LRP5	V					V
RHOA		V	V				V		V		V			V
PRICKLE1		V			V					V	V
FOSL1		V	V
CTNNBIP1		V	V		V			V	V		V			V
MAP3K7		V	V											V
TBL1X		V			V			V
CACYBP		V				V	V			V		V	V
APC		V					V			V		V
SIAH1		V			V				V		V
PRKACB		V		V	V								V
WNT9A		V
PPARD			V			V		V	V		V
FBXW11			V					V						V
CSNK2B			V				V			V		V	V
CSNK1E			V		V						V		V
PORCN			V							V		V	V
DAAM1				V
INVS				V				V	V		V			V
CBY1				V
PLCB3					V						V		V
MAPK9					V									V
CTBP2						V				V		V		V
PPP3CC							V			V				V
CTBP1							V
NLK							V			V		V
BTRC							V
ROCK2								V	V		V
WNT3								V
TPTEP2-CSNK1E									V					V
SERPINF1									V
CHD8												V
RAC1													V
RAC3													V
CSNK2A3													V
TCF7L1														V
+ 04330: Notch signaling pathway	1.4	0	0.1	1	0	1.5	0.5	1	0.2	0.9	2.1	0.9	0.7	0.9
HDAC2	V											V
CREBBP	V					V		V			V		V
DTX2	V			V				V		V	V			V
NUMB	V			V		V					V			V
CIR1			V
APH1A				V		V							V
CTBP2						V				V		V		V
CTBP1							V
NUMBL							V			V		V
RBPJ								V			V
NCSTN									V		V		V
+ 04340: Hedgehog signaling pathway	1	0.8	0.5	1.1	1.1	0.5	1	1.6	1.6	0.2	0.6	0.2	1.2	1
GSK3B	V			V
SMURF2	V			V		V							V
CUL3	V									V			V
CSNK1G3		V			V				V
PRKACB		V		V	V								V
PTCH1		V
CSNK1E			V		V						V		V
FBXW11			V					V						V
KIF3A						V
BTRC							V
ARRB1							V					V
SPOP							V
GPR161								V
CSNK1D								V						V
ARRB2								V	V		V
TPTEP2-CSNK1E									V					V
CSNK1G1									V
+ 04350: TGF-beta signaling pathway	1.2	0.1	0.3	0.6	0.1	0.9	0.1	1	0.7	1.6	1.4	0.5	0.9	0.5
CREBBP	V					V		V			V		V
TFDP1	V			V								V	V
ACVR1	V					V
ROCK1	V					V
SMURF2	V			V		V							V
TGIF1	V			V	V			V		V		V
RHOA		V	V				V		V		V			V
FBN1		V	V		V							V
PPP2R1A			V							V		V	V
RPS6KB1				V		V				V
THSD4							V			V
SMAD2								V		V	V
INHBA								V	V		V			V
SMAD5								V		V	V
AMH									V		V		V
MICOS10-NBL1									V
TGIF2										V
ID1													V
THBS1														V
BMP4														V
+ 04390: Hippo signaling pathway	0.9	0.3	0.9	0.3	0.1	0.3	0.5	2.7	1.2	1.2	1.8	0	0.2	3.3
PARD6B	V					V
SERPINE1	V		V		V			V		V
WNT5B	V			V		V
FZD6	V			V		V		V			V		V
GSK3B	V			V
CCND3	V			V		V	V			V	V			V
BIRC2	V
BBC3	V						V		V
FRMD6		V	V		V					V
CTNNA1		V	V
YWHAE		V						V	V		V			V
MOB1A		V						V	V					V
WNT9A		V
APC		V					V			V		V
PPP1CB			V
LLGL2			V
CSNK1E			V		V						V		V
FBXW11			V					V						V
PPP2R1A			V							V		V	V
YWHAZ				V				V	V		V			V
WWTR1						V				V
STK3							V
TEAD2							V			V
BTRC							V
BIRC5								V	V		V
PPP1CA								V			V
LLGL1								V						V
TEAD4								V						V
SMAD2								V		V	V
CSNK1D								V						V
WNT3								V
TP53BP2									V		V
TPTEP2-CSNK1E									V					V
AMH									V		V		V
SCRIB										V		V
MOB1B													V
ID1													V
LATS1														V
CCN2														V
TEAD3														V
ITGB2														V
TCF7L1														V
BMP4														V
PPP2R2D														V
+ 04392: Hippo signaling pathway - multiple species	0	0.8	0.9	0	1	0.4	0.9	1	1	1.5	1	0	0.7	2.7
FRMD6		V	V		V					V
MOB1A		V						V	V					V
CSNK1E			V		V						V		V
WWTR1						V				V
STK3							V
TEAD2							V			V
TEAD4								V						V
TPTEP2-CSNK1E									V					V
PAK1											V
MOB1B													V
LATS1														V
TEAD3														V
+ 04370: VEGF signaling pathway	0.7	0.3	0	1.2	0.1	0.4	1.6	0	0	0.7	1.3	0.3	2.5	1.1
PPP3CB	V			V		V					V		V
NFATC2	V						V							V
NRAS	V					V
PIK3R2		V
VEGFA		V			V
PLCG1				V
PXN				V									V
HRAS				V			V			V		V		V
PPP3CC							V			V				V
PTK2							V			V		V		V
MAPK14							V
SPHK1											V
PIK3CA											V
MAPK12											V		V
SPHK2													V
PTGS2													V
AKT3													V
RAC1													V
RAC3													V
+ 04371: Apelin signaling pathway	0.2	0	0.1	1	0.3	0.4	0.2	0.3	0	0.6	1.1	0.1	1	0.6
PRKAA1	V			V
SERPINE1	V		V		V			V		V
GNAI2	V			V		V		V
NRAS	V					V
PRKACB		V		V	V								V
CALM2		V	V		V		V		V		V		V
MEF2A			V
PRKAG2				V		V
RPS6KB1				V		V				V
HRAS				V			V			V		V		V
NRF1				V								V
PLCB3					V						V		V
ADCY7						V								V
PRKAB2							V					V	V
TFAM							V			V
GNAI3								V			V
SMAD2								V		V	V
PLIN1									V
MTOR										V
SPHK1											V
MEF2D											V		V
ACTA2											V
SPHK2													V
GNB1													V
AKT3													V
KLF2													V
GNG10														V
GNB4														V
CCN2														V
APLN														V
+ 04064: NF-kappa B signaling pathway	4.5	1.3	3.1	2	1	1.9	0.8	0.9	2.5	1.1	0	1.8	1.1	2.5
BIRC2	V
NFKBIA	V
MYD88	V					V			V					V
IL1B	V												V
TRAF3	V			V		V
NFKB2	V			V										V
NFKB1	V				V				V
TNFAIP3	V					V						V
TRAF1	V		V		V
CXCL8	V
CCL13	V			V		V				V
CSNK2A1	V							V	V					V
CSNK2A2	V							V	V					V
CFLAR	V
CXCL2	V
ICAM1	V
IRAK1		V		V		V			V
MAP3K14		V	V					V
IKBKG		V	V		V		V							V
MAP3K7		V	V											V
MALT1		V	V					V	V					V
TMED7-TICAM2		V	V									V		V
PLAU		V
BIRC3			V
IL1R1			V
IKBKB			V		V		V						V
CSNK2B			V				V			V		V	V
LTB			V
CYLD			V		V					V		V
BCL2L1				V		V								V
TRAF2				V
LTBR				V					V				V
PLCG1				V
TRAF5						V
XIAP						V						V
CHUK							V
TNFSF13B							V			V		V
ERC1								V	V				V
CXCL12									V
ATM										V		V		V
PIDD1										V		V
CSNK2A3													V
PTGS2													V
+ 04668: TNF signaling pathway	5.7	1.4	2.2	2.1	1.5	2.7	1.6	1.1	0.1	0.1	0.5	0.9	2.8	1.6
BIRC2	V
MAP2K7	V			V		V
MAPK8	V			V				V			V
NFKBIA	V
NFKB1	V				V				V
CASP7	V			V		V						V	V
CXCL1	V
CXCL2	V
CXCL3	V
CSF1	V			V				V		V		V	V
CSF2	V											V
IL1B	V												V
IL6	V					V								V
TNFAIP3	V					V						V
TRAF1	V		V		V
ICAM1	V
TRAF3	V			V		V
MAP3K5	V
CFLAR	V
DAB2IP	V			V		V	V							V
IRF1	V					V	V						V
MAP3K7		V	V											V
IKBKG		V	V		V		V							V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
PIK3R2		V
MAP3K14		V	V					V
ITCH		V	V		V			V						V
BIRC3			V
IKBKB			V		V		V						V
CASP8			V					V	V			V	V
CASP3			V					V			V
TRAF2				V
CREB1				V										V
ATF2				V		V	V						V
MAPK9					V									V
TRAF5						V
RPS6KA4						V
MLKL						V
MAPK14							V
CHUK							V
MAPK12											V		V
PIK3CA											V
MMP3													V
PTGS2													V
AKT3													V
+ 04066: HIF-1 signaling pathway	1.7	0.6	0.7	0.8	1.3	1.8	1.1	0.3	0.6	1.7	0.5	0.7	1.6	0.7
CREBBP	V					V		V			V		V
HIF1A	V					V			V		V
EGFR	V					V		V	V		V
LDHA	V						V			V
TFRC	V				V		V					V	V
SERPINE1	V		V		V			V		V
NFKB1	V				V				V
IL6	V					V								V
VEGFA		V			V
ERBB2		V					V			V		V		V
PIK3R2		V
GAPDH		V	V		V								V
ALDOA		V	V		V		V			V		V
CUL2			V
PFKFB3			V			V							V
ARNT				V
PLCG1				V
LTBR				V					V				V
EIF4E				V		V
RPS6KB1				V		V				V
VHL						V	V					V	V
ELOB							V			V		V
MTOR										V
ENO2										V
PIK3CA											V
AKT3													V
ENO1													V
IFNGR2													V
PDK1														V
MKNK2														V
CDKN1A														V
+ 04068: FoxO signaling pathway	1.2	0.3	0.4	0.8	1.2	1.3	1	2.4	0.6	0.9	1.5	0.4	1.1	2.5
MAPK8	V			V				V			V
PRKAA1	V			V
NRAS	V					V
EGFR	V					V		V	V		V
CREBBP	V					V		V			V		V
CDK2	V							V		V
PLK4	V
IL6	V					V								V
PIK3R2		V
CDKN2D		V
BCL2L11		V		V	V
BCL6		V		V						V
SETD7		V						V	V
IKBKB			V		V		V						V
PCK2			V		V		V							V
G6PC3			V		V			V						V
PDPK1			V		V			V						V
CSNK1E			V		V						V		V
PRKAG2				V		V
HRAS				V			V			V		V		V
MAPK9					V									V
ARAF						V
SKP2						V		V			V			V
ATG12						V				V
CHUK							V
PRKAB2							V					V	V
NLK							V			V		V
MAPK14							V
PLK3								V
IL7R								V						V
SMAD2								V		V	V
SOS2									V				V
PLK1									V				V
TPTEP2-CSNK1E									V					V
ATM										V		V		V
PIK3CA											V
MAPK12											V		V
SOD2												V
AKT3													V
KLF2													V
SIRT1														V
CDKN1A														V
+ 04020: Calcium signaling pathway	0	0.4	0	0.3	0.3	0.2	0.5	0	0	0.3	0.5	0.3	0.4	0.1
PPP3CB	V			V		V					V		V
EGFR	V					V		V	V		V
PHKB	V					V
GNAS	V						V						V
ERBB2		V					V			V		V		V
GNA11		V
HRH1		V			V
LTB4R2		V			V		V			V		V	V
CALM2		V	V		V		V		V		V		V
ADORA2A		V
PRKACB		V		V	V								V
STIM2		V	V		V							V
VDAC2			V							V	V
F2R			V
CAMK1				V		V			V
PLCG1				V
ORAI2				V		V
MCU				V
PLCB3					V						V		V
ADCY7						V								V
VDAC3							V			V		V
PPP3CC							V			V				V
TPCN1							V			V		V
CXCR4							V			V		V
SPHK1											V
ATP2A2											V			V
ORAI3												V
P2RX5													V
SPHK2													V
ADORA2B													V
ASPH														V
+ 04070: Phosphatidylinositol signaling system	0.2	2.3	0.7	0.9	1.3	0.5	0.5	0.3	0.7	0.5	0.9	1.1	0.3	0.5
PIP5K1A	V		V					V	V		V			V
PI4KB	V					V	V			V		V	V
ITPK1	V			V		V
CALM2		V	V		V		V		V		V		V
PIK3R2		V
PIKFYVE		V			V		V			V
PIK3C2A		V						V
DGKA		V		V		V
DGKZ		V	V		V				V			V
INPP4B		V
PIP4K2C		V	V					V
PIP4K2B		V												V
MTMR14		V		V			V					V
MTMR4			V		V						V
PLCG1				V
MTMR1				V		V								V
PLCB3					V						V		V
IMPA1					V							V
PPIP5K1									V			V
DGKD										V		V
IPMK										V			V
PIK3CA											V
SYNJ2														V
+ 04072: Phospholipase D signaling pathway	0.7	1.4	0.5	0.9	0.2	0.8	0.5	0.4	1.6	0.7	1.2	0.1	0.9	0.5
NRAS	V					V
SHC1	V			V									V
EGFR	V					V		V	V		V
PTPN11	V			V		V			V
PIP5K1A	V		V					V	V		V			V
GNAS	V						V						V
CXCL8	V
PIK3R2		V
RALGDS		V	V
RHOA		V	V				V		V		V			V
LPAR2		V
TSC2		V			V			V		V
ARF1		V		V					V		V
DGKA		V		V		V
DGKZ		V	V		V				V			V
DNM2		V			V					V
FYN		V									V
F2R			V
CYTH3			V
HRAS				V			V			V		V		V
PLCG1				V
CYTH2				V			V			V
PLCB3					V						V		V
ADCY7						V								V
PDGFA						V
ARF6						V								V
LPAR1							V			V
AGPAT1							V
GAB2								V
PLPP1								V	V				V
SOS2									V				V
AGPAT3									V
MTOR										V
DGKD										V		V
PIK3CA											V
SPHK1											V
AKT3													V
TSC1													V
SPHK2													V
PDGFD													V
AGPAT2														V
+ 04071: Sphingolipid signaling pathway	1.8	0.9	1.4	0.6	1	1.2	0.3	1.6	0.7	0.1	2.4	0.8	1.3	1.4
GNAI2	V			V		V		V
NRAS	V					V
ROCK1	V					V
SPTLC1	V					V
ABCC1	V			V		V			V				V
MAP3K5	V
MAPK8	V			V				V			V
TP53	V		V									V		V
NFKB1	V				V				V
PIK3R2		V
RHOA		V	V				V		V		V			V
NSMAF		V
PPP2R5C		V	V		V		V							V
PPP2R5E		V	V		V									V
SMPD1		V				V						V
FYN		V									V
PDPK1			V		V			V						V
PPP2R3B			V
PPP2R1A			V							V		V	V
BAX			V					V		V		V
HRAS				V			V			V		V		V
TRAF2				V
PLCB3					V						V		V
MAPK9					V									V
CERS2						V		V	V		V
MAPK14							V
GNAI3								V			V
ROCK2								V	V		V
GAB2								V
PIK3CA											V
SPHK1											V
MAPK12											V		V
PPP2R3A												V
AKT3													V
S1PR3													V
SPHK2													V
RAC1													V
RAC3													V
PPP2R2D														V
+ 04024: cAMP signaling pathway	1	0.5	0	0.5	0.1	0.1	0.2	0.3	0.8	0	1.2	0	0.7	0.1
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
GNAI2	V			V		V		V
GNAS	V						V						V
MAPK8	V			V				V			V
ROCK1	V					V
NFKB1	V				V				V
CREBBP	V					V		V			V		V
SOX9	V
NFKBIA	V
PRKACB		V		V	V								V
PIK3R2		V
CALM2		V	V		V		V		V		V		V
CREB3		V											V
CREB3L4		V											V
RHOA		V	V				V		V		V			V
ADORA2A		V
ABCC4		V						V
PTCH1		V
ACOX1		V
PPP1CB			V
F2R			V
CREB1				V										V
PPP1R12A				V		V
RAP1A					V		V			V			V
MAPK9					V									V
ADCY7						V								V
GNAI3								V			V
ROCK2								V	V		V
PPP1CA								V			V
AFDN									V
AMH									V		V		V
ATP2A2											V			V
PIK3CA											V
PAK1											V
AKT3													V
PTGER2													V
RAC1													V
RAC3													V
EDN2														V
+ 04022: cGMP-PKG signaling pathway	0.8	0.4	0.5	0.9	0.1	0.6	1.3	0.1	0.5	0.3	1.6	0	0.4	0.8
ROCK1	V					V
PPP3CB	V			V		V					V		V
NFATC2	V						V							V
NFATC3	V					V				V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
GNAI2	V			V		V		V
RHOA		V	V				V		V		V			V
GNA11		V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
GTF2I		V	V							V		V		V
CALM2		V	V		V		V		V		V		V
PPP1CB			V
MEF2A			V
VDAC2			V							V	V
PPP1R12A				V		V
CREB1				V										V
ATF2				V		V	V						V
PLCB3					V						V		V
ADCY7						V								V
PPP3CC							V			V				V
VDAC3							V			V		V
PPP1CA								V			V
ROCK2								V	V		V
GNAI3								V			V
MEF2D											V		V
ATP2A2											V			V
AKT3													V
+ 04151: PI3K-Akt signaling pathway	0.7	1.3	1	1.8	1.3	1.6	1.3	0.6	0.1	0.9	0.5	0.5	0.2	4.2
EIF4B	V											V		V
EGFR	V					V		V	V		V
GSK3B	V			V
TP53	V		V									V		V
NFKB1	V				V				V
CSF1	V			V				V		V		V	V
NRAS	V					V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
PRKAA1	V			V
CDK2	V							V		V
ITGB1	V			V		V					V			V
LAMB1	V			V			V					V
CSF3	V									V
IL6	V					V								V
CCND3	V			V		V	V			V	V			V
TSC2		V			V			V		V
PIK3R2		V
ERBB2		V					V			V		V		V
FGFR1		V
LPAR2		V
BCL2L11		V		V	V
IKBKG		V	V		V		V							V
YWHAE		V						V	V		V			V
VEGFA		V			V
PPP2R5C		V	V		V		V							V
PPP2R5E		V	V		V									V
ITGA6		V	V		V							V		V
ITGB4		V	V		V					V				V
LAMA3		V
LAMA4		V
LAMC2		V				V		V						V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
MCL1		V	V		V		V			V		V
PKN3		V	V		V		V		V		V
PDPK1			V		V			V						V
MET			V			V					V
F2R			V
PCK2			V		V		V							V
G6PC3			V		V			V						V
IKBKB			V		V		V						V
PPP2R3B			V
PPP2R1A			V							V		V	V
BRCA1			V		V			V			V
EIF4E				V		V
RPS6KB1				V		V				V
BCL2L1				V		V								V
YWHAZ				V				V	V		V			V
HRAS				V			V			V		V		V
CRTC2				V		V
CDK6				V		V	V					V	V
ITGAV				V		V		V		V
COL6A1				V
CREB1				V										V
ATF2				V		V	V						V
PDGFA						V
TGFA						V	V						V
ITGA2						V						V
LAMB2						V								V
LAMC1						V								V
LPAR1							V			V
CHUK							V
COL4A5							V		V					V
PTK2							V			V		V		V
IL7R								V						V
NR4A1								V	V		V
SOS2									V				V
MTOR										V
PIK3CA											V
PKN1											V
CCNE1											V
PPP2R3A												V
TSC1													V
AKT3													V
PDGFD													V
GNB1													V
RAC1													V
MAGI1													V
PPP2R2D														V
CDKN1A														V
GNG10														V
GNB4														V
THBS1														V
+ 04152: AMPK signaling pathway	0.3	1.9	3	2.3	1.7	1.5	0.5	0.9	0.1	1.7	0.4	0.8	2.2	3.4
PRKAA1	V			V
ADIPOR1	V			V				V
PFKM	V		V			V	V				V			V
CAB39	V					V				V			V
PIK3R2		V
ADIPOR2		V	V				V							V
ACACA		V		V						V	V			V
FBP1		V
TSC2		V			V			V		V
PPP2R5C		V	V		V		V							V
PPP2R5E		V	V		V									V
MAP3K7		V	V											V
CREB3		V											V
CREB3L4		V											V
PDPK1			V		V			V						V
CPT1C			V					V	V		V
PFKFB3			V			V							V
PCK2			V		V		V							V
G6PC3			V		V			V						V
STRADA			V							V		V
PPP2R3B			V
PPP2R1A			V							V		V	V
PRKAG2				V		V
SREBF1				V	V									V
RPS6KB1				V		V				V
CRTC2				V		V
TBC1D1				V		V
ELAVL1				V
CREB1				V										V
HMGCR					V
PFKFB2						V				V		V
PRKAB2							V					V	V
MLYCD								V	V
CPT1A										V		V
MTOR										V
PIK3CA											V
PPP2R3A												V
AKT3													V
AKT1S1													V
SCD													V
PPARG													V
CCNA1													V
TSC1													V
SIRT1														V
CAMKK2														V
PPP2R2D														V
+ 04150: mTOR signaling pathway	1.5	0.8	0.9	2	0.4	3.1	1	0.6	0.2	1.5	0.6	0.7	0.6	0.7
NRAS	V					V
PRKAA1	V			V
ULK2	V					V
EIF4B	V											V		V
RICTOR	V			V		V	V			V		V
GSK3B	V			V
WNT5B	V			V		V
FZD6	V			V		V		V			V		V
LRP5	V					V
CAB39	V					V				V			V
PIK3R2		V
TSC2		V			V			V		V
RHOA		V	V				V		V		V			V
RRAGB		V
RPS6KA1		V
NPRL3		V			V
WNT9A		V
CLIP1		V	V			V								V
PDPK1			V		V			V						V
RRAGC			V		V
IKBKB			V		V		V						V
NPRL2			V
FNIP1			V
STRADA			V							V		V
HRAS				V			V			V		V		V
LPIN1				V		V		V			V
RPS6KB1				V		V				V
EIF4E				V		V
TTI1				V
MAPKAP1				V		V	V			V		V		V
SKP2						V		V			V			V
SEC13						V	V			V		V
ATP6V1D						V						V	V
TBC1D7							V		V
CHUK							V
WNT3								V
SOS2									V				V
MIOS									V
LAMTOR2										V
MTOR										V
PIK3CA											V
GRB10											V
AKT3													V
TSC1													V
AKT1S1													V
+ 3.3 Signaling molecules and interaction	1.9	0.6	0.3	0.7	0.2	1.2	0.2	0.3	0.2	0.3	0.1	0.5	0.1	1.3
+ 04080: Neuroactive ligand-receptor interaction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
VIPR1	V			V
C3	V
THRA		V	V			V	V
NR3C1		V	V		V					V		V
GLRB		V	V		V			V
LTB4R2		V			V		V			V		V	V
LPAR2		V
ADORA2A		V
HRH1		V			V
F2R			V
TSPO				V
NMU				V			V						V
LPAR1							V			V
P2RX5													V
S1PR3													V
ADORA2B													V
PTGER2													V
NMB													V
IAPP													V
CHRNB1														V
APLN														V
EDN2														V
+ 04060: Cytokine-cytokine receptor interaction	1.4	0	0	0	0	0	0	0.1	0	0	0	0	0	0
LIFR	V							V	V
ACVR1	V					V
IL1B	V												V
IL1A	V
IL24	V
CSF2RA	V		V				V			V	V			V
CSF2	V											V
CSF3	V									V
IL6	V					V								V
CXCL8	V
TNFSF15	V
CXCL1	V
CXCL2	V
CXCL3	V
CCL13	V			V		V				V
IL32	V										V			V
CSF1	V			V				V		V		V	V
IL1RAP		V										V	V
IL17RC		V	V					V					V
IL1R1			V
TNFRSF14			V
LTB			V
LTBR				V					V				V
GDF15				V		V		V			V
TNFRSF10A					V
IL17RA						V
IL23A						V
CLCF1						V		V
TNFSF13B							V			V		V
CXCR4							V			V		V
INHBA								V	V		V			V
IL7R								V						V
GDF11								V	V
AMH									V		V		V
CXCL12									V
IL6ST													V
IFNGR2													V
IL11													V
IL18														V
BMP4														V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	1.8	0	0	0.3	0	0.1	0	0	0.1	0.2	0	0.1	0.1	0.1
CCL13	V			V		V				V
CXCL1	V
CXCL2	V
CXCL3	V
CXCL8	V
IL6	V					V								V
IL24	V
CSF1	V			V				V		V		V	V
TNFRSF14			V
LTBR				V					V				V
TNFRSF10A					V
CXCR4							V			V		V
CXCL12									V
IL6ST													V
IL18														V
+ 04512: ECM-receptor interaction	0.6	1.2	0.6	1.1	0.5	2.2	0.4	0.4	0.2	0.3	0.2	1	0.1	2.5
LAMB1	V			V			V					V
DAG1	V		V			V	V		V			V		V
ITGB1	V			V		V					V			V
HMMR	V												V
LAMA3		V
LAMA4		V
LAMC2		V				V		V						V
ITGA6		V	V		V							V		V
HSPG2		V				V		V		V		V
ITGB4		V	V		V					V				V
CD47			V
COL6A1				V
ITGAV				V		V		V		V
CD44				V	V						V		V
LAMB2						V								V
LAMC1						V								V
ITGA2						V						V
COL4A5							V		V					V
THBS1														V
+ 4. Cellular Processes	9.3	6.9	6.6	7.5	5.2	7.8	7.3	6.5	5	7.9	6.9	6.7	4.5	9.9
+ 4.1 Transport and catabolism	6.1	3.3	3.7	5.9	3.5	5	5.3	4.1	4.2	4.8	3.6	4.9	3.4	5.4
+ 04144: Endocytosis	3.7	2.7	2.7	4.3	4	3.9	3.6	3.1	3.5	3	3.7	3.3	3.8	3
NEDD4L	V			V		V
SMURF2	V			V		V							V
LDLR	V			V		V		V						V
CLTA	V			V				V	V					V
CLTB	V			V		V		V						V
AP2A2	V			V		V		V	V		V			V
AP2B1	V
HSPA1B	V			V		V	V			V				V
PARD6B	V					V
TFRC	V				V		V					V	V
EPS15L1	V			V		V	V						V
RAB5C	V					V	V					V		V
EGFR	V					V		V	V		V
PIP5K1A	V		V					V	V		V			V
ARFGEF1	V					V
ASAP1	V			V		V			V
SMAP2	V
ASAP2	V			V			V					V
HLA-E	V			V		V		V	V		V		V
WASHC4	V					V		V	V			V
BIN1	V		V		V
ARPC2	V			V
SNX3	V			V			V			V		V	V
IST1	V			V		V	V			V		V	V
STAM2		V
DNM2		V			V					V
RNF41		V										V
ITCH		V	V		V			V						V
CLTC		V						V					V
VPS37A		V						V					V
HSPA1A		V												V
CHMP1A		V	V
CHMP2A		V	V
VTA1		V	V		V		V			V	V
SH3GLB1		V	V		V				V		V			V
ARFGAP3		V	V		V				V
GIT1		V				V
ARFGAP1		V	V		V
SMAP1		V			V								V
GIT2		V	V		V								V
HLA-B		V				V				V		V		V
HLA-C		V	V		V		V			V			V
PML		V	V		V			V				V	V
RHOA		V	V				V		V		V			V
ARF1		V		V					V		V
VPS37B			V		V
CHMP4B			V		V								V
CHMP4A			V		V								V
CYTH3			V
ASAP3			V		V									V
RBSN			V
RUFY1			V		V		V					V	V
HGS				V
NEDD4				V		V			V			V		V
AP2S1				V		V							V
HRAS				V			V			V		V		V
EPN2				V
RAB5B				V						V			V
CYTH2				V			V			V
AGAP3				V				V	V		V
CAPZB				V		V						V	V
SNX5				V							V
USP8					V					V		V
HLA-A					V				V		V
CAV1					V						V
SNX4					V								V
SNX1					V		V			V				V
SNX2					V		V			V		V
SNF8						V				V
ARF6						V								V
PSD3						V
CAV2						V	V		V		V		V
VPS37C							V					V
CXCR4							V			V		V
SH3GLB2							V			V		V
ARRB1							V					V
GBF1							V						V
ACAP3							V						V
VPS45							V
SH3GL1								V	V		V			V
ARRB2								V	V		V
RAB11FIP5								V	V
RABEP1								V		V	V		V
SMAD2								V		V	V
RAB11FIP3								V	V		V			V
SNX12								V	V		V		V
CHMP5									V			V
DAB2										V		V	V
ARAP1										V			V
VPS26A										V
ZFYVE27											V
WASHC2C											V
WASHC2A											V
MVB12A												V		V
VPS29													V
SPG21													V
MVB12B														V
+ 04145: Phagosome	2.7	0.2	0	1.7	1.5	1	1.3	0.6	0.9	2.1	2.4	1.8	0.6	2.4
ITGB1	V			V		V					V			V
RAB5C	V					V	V					V		V
TUBB	V				V		V			V		V		V
TUBB2A	V				V		V			V		V		V
TUBB6	V									V			V
M6PR	V							V	V		V			V
C3	V
SEC61A2	V			V							V
CANX	V			V			V
HLA-DRB1	V		V		V				V		V
TAP2	V			V		V	V		V			V
CTSS	V				V
HLA-E	V			V		V		V	V		V		V
TFRC	V				V		V					V	V
RILP		V			V						V
TUBA4A		V							V		V			V
PIKFYVE		V			V		V			V
HLA-B		V				V				V		V		V
HLA-C		V	V		V		V			V			V
ATP6V0A4			V											V
ITGAV				V		V		V		V
RAB5B				V						V			V
HGS				V
HLA-DPA1				V
CORO1A				V
HLA-A					V				V		V
ITGA2						V						V
ATP6V1D						V						V	V
TUBA1A							V					V
DYNC1LI2								V						V
DYNC2H1								V	V		V
MBL2								V			V			V
NCF2										V		V
TCIRG1										V
SCARB1										V
COLEC11										V
DYNC1I2											V
HLA-DRA											V
TUBB2B												V
RAC1													V
ATP6V0B													V
ITGB2														V
LAMP2														V
THBS1														V
+ 04142: Lysosome	3.3	2.1	2.3	3.2	0.7	2.1	3.4	1.9	1.3	3	0.6	3.3	1.5	2
CTSB	V			V		V
CTSK	V			V
CTSO	V			V
CTSS	V				V
CTSA	V					V				V		V	V
NAPSA	V						V			V		V	V
GBA	V		V				V			V		V		V
MAN2B1	V
NPC1	V						V			V
CLTA	V			V				V	V					V
CLTB	V			V		V		V						V
M6PR	V							V	V		V			V
AP1M2	V			V		V	V							V
AP1S2	V
ACP2		V				V
SMPD1		V				V						V
CD63		V		V	V				V			V	V
ABCB9		V	V
CLN3		V		V								V
CD164		V
CLTC		V						V					V
AP1S3		V						V
AP1B1		V	V			V	V			V		V		V
AP1M1		V	V				V		V		V
AP3B1		V			V
ATP6V0A4			V											V
LGMN			V
GLB1			V		V					V		V
GUSB			V
SCARB2			V
GGA3			V					V			V		V
SUMF1			V		V					V		V	V
GNPTG				V			V						V
SLC11A2				V			V			V	V
AP1G1				V			V					V		V
AP4S1				V			V			V		V
HYAL1				V
IDUA						V
GNPTAB						V			V
GGA2						V
GLA							V			V
ARSB							V					V
GALNS							V			V		V
LITAF							V
NPC2								V	V		V
AP3S2								V	V
AP4B1								V
TCIRG1										V
AP3D1										V				V
MANBA												V
ATP6V0B													V
LIPA													V
AP3M2													V
LAMP2														V
+ 04146: Peroxisome	0	0.6	0.4	0.5	0.9	0.8	1.9	0.8	1.3	1.1	0	1.5	1.8	0.4
MPV17	V			V									V
ACAA1		V				V			V
ACOX1		V
ACSL1		V			V		V			V				V
SLC25A17		V	V		V			V	V
PEX11B			V
IDH1			V
PEX13				V			V			V		V
PEX19				V						V				V
PEX2					V		V			V		V	V
DECR2					V		V					V
PEX5						V
SCP2						V					V		V
PXMP4						V
HSD17B4							V						V
HACL1							V					V	V
ECI2							V			V		V	V
MLYCD								V	V
ACSL5								V	V
PRDX1								V
MVK									V				V
SOD2												V
PRDX5													V
AMACR														V
+ 04140: Autophagy - animal	1.6	1.7	1.6	3.1	1.6	1.7	0.7	1.5	0.6	1	0.9	0.2	0.2	1.9
NRAS	V					V
HIF1A	V					V			V		V
ULK2	V					V
ATG13	V			V
PRKAA1	V			V
MAPK8	V			V				V			V
DAPK3	V			V			V			V
CFLAR	V
CTSB	V			V		V
PIK3R2		V
TSC2		V			V			V		V
ATG2A		V	V					V
RRAGB		V
MAP3K7		V	V											V
PRKACB		V		V	V								V
SH3GLB1		V	V		V				V		V			V
MTMR14		V		V			V					V
ATG7		V	V		V
ATG4D		V	V
PDPK1			V		V			V						V
RRAGC			V		V
MTMR4			V		V						V
ATG5			V				V					V	V
HRAS				V			V			V		V		V
RPS6KB1				V		V				V
TP53INP2				V		V		V	V					V
BCL2L1				V		V								V
UVRAG				V
HMGB1				V				V
MAPK9					V									V
IGBP1						V	V
ATG12						V				V
ZFYVE1							V			V		V
PRKCD								V	V
ATG9A								V	V		V
MTOR										V
PIK3CA											V
AKT3													V
TSC1													V
AKT1S1													V
ATG101														V
CAMKK2														V
LAMP2														V
+ 04136: Autophagy - other	0.8	1.3	1.9	0.3	0.4	1.4	0.8	0.9	0.4	0.8	0.4	0.3	0.2	0.3
ULK2	V					V
ATG13	V			V
ATG2A		V	V					V
ATG4D		V	V
ATG7		V	V		V
ATG5			V				V					V	V
IGBP1						V	V
ATG12						V				V
ATG9A								V	V		V
MTOR										V
ATG101														V
+ 04137: Mitophagy - animal	3.9	0.1	1	2.4	0.4	2.3	2.3	2	3	1.8	1.6	2.7	0.7	4.3
OPTN	V			V		V
NBR1	V			V		V	V		V			V		V
CSNK2A1	V							V	V					V
CSNK2A2	V							V	V					V
MITF	V
TAX1BP1	V			V		V		V			V			V
BCL2L13	V					V			V		V			V
HIF1A	V					V			V		V
TP53	V		V									V		V
NRAS	V					V
MAPK8	V			V				V			V
MFN1		V					V			V				V
CALCOCO2			V						V
CSNK2B			V				V			V		V	V
ATG5			V				V					V	V
BCL2L1				V		V								V
TBC1D17				V			V			V			V
HRAS				V			V			V		V		V
USP8					V					V		V
MAPK9					V									V
TBC1D15							V			V		V		V
SQSTM1								V	V			V		V
ATG9A								V	V		V
CSNK2A3													V
+ 4.2 Cell growth and death	7.4	4.3	6.1	5.3	5.1	4.2	5.1	5.3	2.7	7.1	5.3	5.7	3	6.7
+ 04110: Cell cycle	4.2	2.1	0.4	2.9	0.4	2.1	1.7	3.2	1	3.6	1.6	2.6	2.7	4.8
MCM4	V			V									V
ANAPC11	V			V		V		V		V		V	V
CDK1	V		V							V				V
CDC14B	V					V		V						V
CREBBP	V					V		V			V		V
SMC1A	V			V
TP53	V		V									V		V
CDKN1C	V
CDC25B	V							V		V				V
GSK3B	V			V
CDK7	V					V							V
CDK2	V							V		V
CCND3	V			V		V	V			V	V			V
STAG2	V			V		V			V		V		V
ABL1	V			V		V	V			V		V		V
TFDP1	V			V								V	V
HDAC2	V											V
FZR1		V
MCM2		V	V						V
ANAPC2		V
CDC16		V						V	V				V
CDC27		V						V						V
YWHAE		V						V	V		V			V
CHEK1		V								V		V
PKMYT1		V						V						V
ESPL1		V			V
MAD1L1		V	V				V			V		V
CDKN2D		V
CDC25A			V				V			V
MCM3				V			V							V
YWHAZ				V				V	V		V			V
CDC45				V
CDK6				V		V	V					V	V
ORC1					V									V
BUB3					V								V
TFDP2					V			V						V
MCM7						V						V	V
SKP2						V		V			V			V
ANAPC4							V			V		V	V
ANAPC5							V
CCNH							V			V		V	V
SMAD2								V		V	V
PLK1									V				V
ATM										V		V		V
SMC3										V				V
E2F3										V
CCNE1											V
CCNA1													V
CDKN1A														V
TTK														V
ZBTB17														V
+ 04114: Oocyte meiosis	0.7	3	1.6	1.2	1	0.3	1.4	2.2	0.7	1.7	1.9	0.3	1.2	2.7
CDK1	V		V							V				V
ANAPC11	V			V		V		V		V		V	V
CDK2	V							V		V
PPP3CB	V			V		V					V		V
CPEB4	V			V		V
SMC1A	V			V
MAD1L1		V	V				V			V		V
PKMYT1		V						V						V
RPS6KA1		V
ANAPC2		V
CDC16		V						V	V				V
CDC27		V						V						V
AURKA		V	V		V			V		V	V			V
CALM2		V	V		V		V		V		V		V
PRKACB		V		V	V								V
YWHAE		V						V	V		V			V
ESPL1		V			V
PPP2R5C		V	V		V		V							V
PPP2R5E		V	V		V									V
SLK		V									V
FBXW11			V					V						V
PPP1CB			V
PPP2R1A			V							V		V	V
YWHAZ				V				V	V		V			V
SGO1				V
ADCY7						V								V
ANAPC4							V			V		V	V
ANAPC5							V
BTRC							V
PPP3CC							V			V				V
MAPK14							V
PPP1CA								V			V
PLK1									V				V
SMC3										V				V
CCNE1											V
MAPK12											V		V
+ 04210: Apoptosis	4.8	0.7	2.7	2.9	3.1	2.2	3.1	1.4	1.5	1.8	2	2.4	0.3	2.4
TP53	V		V									V		V
BIRC2	V
DFFB	V						V
CASP7	V			V		V						V	V
NFKB1	V				V				V
NFKBIA	V
CFLAR	V
SPTAN1	V			V			V				V
DIABLO	V					V	V							V
BBC3	V						V		V
TRAF1	V		V		V
MAP3K5	V
MAPK8	V			V				V			V
DAB2IP	V			V		V	V							V
CTSB	V			V		V
CTSK	V			V
CTSO	V			V
CTSS	V				V
CASP2	V					V					V
NRAS	V					V
MAP3K14		V	V					V
IKBKG		V	V		V		V							V
PIK3R2		V
LMNA		V				V		V	V			V	V
BCL2L11		V		V	V
TUBA4A		V							V		V			V
MCL1		V	V		V		V			V		V
BIRC3			V
CASP3			V					V			V
CASP8			V					V	V			V	V
CAPN1			V							V	V
IKBKB			V		V		V						V
HTRA2			V		V					V
BAX			V					V		V		V
PDPK1			V		V			V						V
BCL2L1				V		V								V
AIFM1				V					V
TRAF2				V
DAXX				V			V			V				V
HRAS				V			V			V		V		V
DFFA					V
TNFRSF10A					V
PARP3					V
MAPK9					V									V
XIAP						V						V
CAPN2						V	V			V	V		V
LMNB2						V								V
APAF1							V			V		V
CHUK							V
TUBA1A							V					V
BIRC5								V	V		V
LMNB1									V
ATM										V		V		V
PIDD1										V		V
PIK3CA											V
PARP2											V
AKT3													V
+ 04215: Apoptosis - multiple species	2.5	0.7	3	2.1	1.5	2	1.4	3.2	1.6	1.4	1.5	2.5	1.2	1.4
CASP7	V			V		V						V	V
BIRC2	V
DIABLO	V					V	V							V
MAPK8	V			V				V			V
BBC3	V						V		V
BOK		V	V										V
BCL2L11		V		V	V
CASP3			V					V			V
BIRC3			V
HTRA2			V		V					V
BAX			V					V		V		V
CASP8			V					V	V			V	V
BCL2L1				V		V								V
MAPK9					V									V
XIAP						V						V
APAF1							V			V		V
BIRC5								V	V		V
BIRC6								V
+ 04216: Ferroptosis	0.6	2.5	2.6	0.7	1.8	0	2.7	0.7	0.3	2.2	0.7	2.2	0.5	1.7
TP53	V		V									V		V
TFRC	V				V		V					V	V
GCLM		V	V
STEAP3		V	V											V
ATG7		V	V		V
SLC39A14		V						V						V
PRNP		V		V						V		V
ACSL1		V			V		V			V				V
VDAC2			V							V	V
ATG5			V				V					V	V
SLC11A2				V			V			V	V
PCBP2					V		V
VDAC3							V			V		V
ACSL5								V	V
+ 04217: Necroptosis	1.9	0.3	2.7	1	4.3	1.4	0	0.7	0.8	1.3	0.8	1.9	0.5	0.6
BIRC2	V
CFLAR	V
TNFAIP3	V					V						V
EIF2AK2	V		V						V		V			V
STAT1	V			V	V				V
STAT5A	V			V										V
IL1A	V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
IL1B	V												V
MAPK8	V			V				V			V
H2AFV	V
RBCK1		V	V
TMED7-TICAM2		V	V									V		V
SMPD1		V				V						V
H2AFJ		V	V		V					V			V
CHMP2A		V	V
CHMP1A		V	V
BIRC3			V
CASP8			V					V	V			V	V
CYLD			V		V					V		V
USP21			V							V		V
CAPN1			V							V	V
BAX			V					V		V		V
CHMP4B			V		V								V
CHMP4A			V		V								V
VDAC2			V							V	V
TRAF2				V
HMGB1				V				V
AIFM1				V					V
TNFRSF10A					V
MAPK9					V									V
HIST1H2AB					V
HIST2H2AB					V
HIST2H2AA4					V
HIST2H2AA3					V
HIST1H2AI					V
HIST1H2AM					V
HIST1H2AG					V
HIST1H2AJ					V
HIST1H2AC					V			V
HIST2H2AC					V
HIST1H2AH					V
PARP3					V
TRAF5						V
MLKL						V
XIAP						V						V
RNF31						V
STAT5B						V
CAPN2						V	V			V	V		V
PPIA						V
VDAC3							V			V		V
SQSTM1								V	V			V		V
CHMP5									V			V
GLUD1										V
PARP2											V
IFNGR2													V
NLRP3													V
+ 04115: p53 signaling pathway	2.9	2.3	2.8	2.6	1.5	1.7	1.3	2.3	0.7	4	2.3	2.9	1	2.5
CDK2	V							V		V
RRM2	V			V		V		V			V		V
CD82	V			V
SERPINE1	V		V		V			V		V
GTSE1	V			V		V							V
CDK1	V		V							V				V
TP53	V		V									V		V
CCND3	V			V		V	V			V	V			V
BBC3	V						V		V
SIAH1		V			V				V		V
CHEK1		V								V		V
TSC2		V			V			V		V
RRM2B		V	V
DDB2		V			V						V
STEAP3		V	V											V
SHISA5		V		V	V		V			V			V
SIVA1		V	V							V		V
BAX			V					V		V		V
CASP8			V					V	V			V	V
CASP3			V					V			V
CCNG1				V		V					V
CDK6				V		V	V					V	V
BCL2L1				V		V								V
APAF1							V			V		V
ATM										V		V		V
PIDD1										V		V
CCNE1											V
THBS1														V
CDKN1A														V
+ 04218: Cellular senescence	3.4	0.4	1.3	1.6	0.8	2.1	2.9	1.3	1.1	4.2	4	1.4	1.2	2.9
TP53	V		V									V		V
NRAS	V					V
ETS1	V			V		V			V		V
CCND3	V			V		V	V			V	V			V
CDK2	V							V		V
MRE11	V			V
CDK1	V		V							V				V
NFKB1	V				V				V
ZFP36L1	V			V		V
IL1A	V
PPP3CB	V			V		V					V		V
NFATC2	V						V							V
NFATC3	V					V				V
IL6	V					V								V
CXCL8	V
SERPINE1	V		V		V			V		V
HLA-E	V			V		V		V	V		V		V
HIPK3		V			V
PIK3R2		V
TSC2		V			V			V		V
CHEK1		V								V		V
CALM2		V	V		V		V		V		V		V
HLA-B		V				V				V		V		V
HLA-C		V	V		V		V			V			V
PPP1CB			V
CDC25A			V				V			V
CAPN1			V							V	V
FBXW11			V					V						V
VDAC2			V							V	V
HRAS				V			V			V		V		V
CDK6				V		V	V					V	V
LIN52				V		V	V
MCU				V
HLA-A					V				V		V
CAPN2						V	V			V	V		V
RASSF5							V						V
MAPK14							V
MYBL2							V					V		V
PPP3CC							V			V				V
BTRC							V
VDAC3							V			V		V
PPP1CA								V			V
FOXM1								V	V		V			V
SQSTM1								V	V			V		V
SMAD2								V		V	V
LIN54									V		V
MTOR										V
E2F3										V
ATM										V		V		V
HIPK1											V
PIK3CA											V
CCNE1											V
MAPK12											V		V
TRAF3IP2											V
LIN37												V
AKT3													V
TSC1													V
CCNA1													V
SIRT1														V
CDKN1A														V
+ 4.3 Cellular community - eukaryotes	4.4	3.3	2.5	2.8	1.5	4.5	2.4	2.6	2.5	2.5	3.9	1.7	2.2	5.6
+ 04510: Focal adhesion	1.1	2.9	1.1	1.9	1.5	3.1	1.4	0.6	0.5	1.4	2.2	0.7	1.1	3
ITGB1	V			V		V					V			V
FLNB	V			V		V				V
ROCK1	V					V
LAMB1	V			V			V					V
BIRC2	V
CCND3	V			V		V	V			V	V			V
EGFR	V					V		V	V		V
SHC1	V			V									V
CRK	V		V		V		V			V				V
MAPK8	V			V				V			V
GSK3B	V			V
ITGB4		V	V		V					V				V
ITGA6		V	V		V							V		V
FLNC		V												V
DIAPH1		V	V					V		V				V
VCL		V	V		V							V
PIK3R2		V
ZYX		V	V		V					V		V
ARHGAP5		V			V
FYN		V									V
RHOA		V	V				V		V		V			V
LAMA3		V
LAMA4		V
LAMC2		V				V		V						V
ERBB2		V					V			V		V		V
VEGFA		V			V
BCAR1		V							V				V
PAK4		V					V						V
BUB1B-PAK6		V
PAK6		V
PPP1CB			V
PDPK1			V		V			V						V
BIRC3			V
MET			V			V					V
ITGAV				V		V		V		V
MYL12A				V
PPP1R12A				V		V
PXN				V									V
COL6A1				V
HRAS				V			V			V		V		V
CAV1					V						V
RAP1A					V		V			V			V
MAPK9					V									V
ITGA2						V						V
ILK						V
CAPN2						V	V			V	V		V
LAMB2						V								V
LAMC1						V								V
CAV2						V	V		V		V		V
XIAP						V						V
PDGFA						V
DOCK1						V
PTK2							V			V		V		V
COL4A5							V		V					V
PPP1CA								V			V
ROCK2								V	V		V
SOS2									V				V
PIK3CA											V
PAK1											V
AKT3													V
ELK1													V
PDGFD													V
RAC1													V
RAC3													V
THBS1														V
+ 04520: Adherens junction	2.5	3.4	3.6	0.3	1	2.5	0.9	3.1	3.6	1.3	3.1	0.9	1.7	4
CTNND1	V			V		V		V	V					V
CREBBP	V					V		V			V		V
EGFR	V					V		V	V		V
CSNK2A1	V							V	V					V
CSNK2A2	V							V	V					V
PTPRJ	V
PTPRM	V					V							V
TJP1	V		V			V			V		V			V
CTNNA1		V	V
MAP3K7		V	V											V
YES1		V							V		V		V
FYN		V									V
FGFR1		V
ERBB2		V					V			V		V		V
PTPN1		V	V		V			V						V
ACP1		V	V		V
RHOA		V	V				V		V		V			V
BAIAP2		V	V		V			V	V		V			V
VCL		V	V		V							V
MET			V			V					V
CSNK2B			V				V			V		V	V
NECTIN3			V
FER				V		V
SSX2IP						V
NLK							V			V		V
SMAD2								V		V	V
PTPN6								V	V					V
AFDN									V
NECTIN2										V				V
CSNK2A3													V
RAC1													V
RAC3													V
TCF7L1														V
+ 04530: Tight junction	2.4	0.6	0.7	2.3	0.1	1.9	1.3	0.1	0.5	1	1	1	0.8	2.1
PARD6B	V					V
TJP1	V		V			V			V		V			V
ROCK1	V					V
MICALL2	V													V
MAP2K7	V			V		V
MAP3K5	V
MAPK8	V			V				V			V
RDX	V			V				V			V		V
CLDN4	V			V		V					V		V
PRKAA1	V			V
TJP2	V			V		V	V			V				V
CTTN	V			V		V						V
ITGB1	V			V		V					V			V
NEDD4L	V			V		V
RHOA		V	V				V		V		V			V
PRKACB		V		V	V								V
RAP2C		V	V				V			V		V		V
TUBA4A		V							V		V			V
ERBB2		V					V			V		V		V
RUNX1		V	V				V
SYMPK		V	V		V
MYL6B		V					V			V		V	V
PPP2R1A			V							V		V	V
LLGL2			V
MPDZ			V
PRKAG2				V		V
MYL12A				V
NEDD4				V		V			V			V		V
RAP1A					V		V			V			V
MAPK9					V									V
EPB41L4B						V
PRKAB2							V					V	V
TUBA1A							V					V
AMOTL2							V							V
ROCK2								V	V		V
LLGL1								V						V
AFDN									V
F11R										V
CLDN15										V
SCRIB										V		V
RAC1													V
MAGI1													V
CLDN7													V
PPP2R2D														V
+ 04540: Gap junction	2.8	0.3	0.1	0.7	0.8	1.4	1.4	0.7	0.8	1.3	1.1	0.9	1	2.4
GNAI2	V			V		V		V
MAP2K5	V			V										V
CDK1	V		V							V				V
TJP1	V		V			V			V		V			V
TUBB	V				V		V			V		V		V
TUBB2A	V				V		V			V		V		V
TUBB6	V									V			V
NRAS	V					V
EGFR	V					V		V	V		V
GNAS	V						V						V
PRKACB		V		V	V								V
TUBA4A		V							V		V			V
GNA11		V
HRAS				V			V			V		V		V
PLCB3					V						V		V
ADCY7						V								V
PDGFA						V
LPAR1							V			V
TUBA1A							V					V
CSNK1D								V						V
GNAI3								V			V
SOS2									V				V
TUBB2B												V
PDGFD													V
+ 04550: Signaling pathways regulating pluripotency of stem cells	1.1	0.2	0.1	1	0	1.2	0.4	1.3	0.1	0.6	1.4	0.3	0.3	0.8
WNT5B	V			V		V
FZD6	V			V		V		V			V		V
GSK3B	V			V
LIFR	V							V	V
ACVR1	V					V
NRAS	V					V
PCGF2	V			V		V		V	V		V			V
PCGF5	V			V		V	V			V
WNT9A		V
APC		V					V			V		V
PIK3R2		V
FGFR1		V
RIF1		V	V			V
KLF4			V		V		V					V		V
PCGF3			V
HRAS				V			V			V		V		V
JARID2				V						V		V
KAT6A						V		V			V		V
MAPK14							V
WNT3								V
INHBA								V	V		V			V
SMAD2								V		V	V
SMAD5								V		V	V
PIK3CA											V
MAPK12											V		V
PCGF1												V
IL6ST													V
AKT3													V
ID1													V
BMP4														V
TCF3														V
REST														V
+ 4.5 Cell motility	0.7	2.9	0.9	0.9	0.2	1.8	1.8	0.9	0.6	1.4	1	1	0.4	2
+ 04810: Regulation of actin cytoskeleton	0.7	2.9	0.9	0.9	0.2	1.8	1.8	0.9	0.6	1.4	1	1	0.4	2
ARPC2	V			V
CYFIP1	V			V		V	V					V	V
SSH2	V					V				V		V		V
PIP5K1A	V		V					V	V		V			V
RDX	V			V				V			V		V
ROCK1	V					V
CRK	V		V		V		V			V				V
ITGB1	V			V		V					V			V
NRAS	V					V
EGFR	V					V		V	V		V
APC		V					V			V		V
BAIAP2		V	V		V			V	V		V			V
LIMK1		V
GSN		V					V			V				V
VCL		V	V		V							V
PIKFYVE		V			V		V			V
PIP4K2C		V	V					V
PIP4K2B		V												V
DIAPH1		V	V					V		V				V
GIT1		V				V
PAK4		V					V						V
BUB1B-PAK6		V
PAK6		V
RHOA		V	V				V		V		V			V
PIK3R2		V
BCAR1		V							V				V
ITGA6		V	V		V							V		V
ITGB4		V	V		V					V				V
FGFR1		V
LPAR2		V
PPP1CB			V
F2R			V
PXN				V									V
PPP1R12A				V		V
MYL12A				V
ARHGEF1				V
ITGAV				V		V		V		V
HRAS				V			V			V		V		V
ENAH						V	V			V				V
ARAF						V
DOCK1						V
ITGA2						V						V
PDGFA						V
PFN1							V					V
CYFIP2							V					V
PTK2							V			V		V		V
CXCR4							V			V		V
LPAR1							V			V
PPP1CA								V			V
ROCK2								V	V		V
IQGAP3								V
SOS2									V				V
CXCL12									V
PAK1											V
PIK3CA											V
RAC1													V
RAC3													V
ARHGEF12													V
PDGFD													V
ITGB2														V
+ 5. Organismal Systems	10.3	4.9	3.7	10.7	5.8	5.5	7.8	4.4	5.7	3.8	6.3	2.7	8	7.9
+ 5.1 Immune system	9.6	2.7	3.9	5.7	4.4	3.3	5.6	2.3	4.1	2.3	4.9	1.7	4.6	5.3
+ 04640: Hematopoietic cell lineage	2.2	0.1	0.8	0.3	0.7	0.1	0.1	0.1	0	0.5	0.6	1.2	0.8	1.2
CSF2RA	V		V				V			V	V			V
TFRC	V				V		V					V	V
HLA-DRB1	V		V		V				V		V
CSF1	V			V				V		V		V	V
CSF3	V									V
IL6	V					V								V
CSF2	V											V
IL1A	V
IL1B	V												V
ITGA6		V	V		V							V		V
CD55		V	V							V		V	V
IL1R1			V
CD44				V	V						V		V
HLA-DPA1				V
ITGA2						V						V
IL7R								V						V
HLA-DRA											V
IL11													V
CD59														V
CD24														V
+ 04610: Complement and coagulation cascades	0.4	0.6	0.4	0	0.2	0	0.8	0.9	0.9	0.7	1.3	0.2	0.1	1.1
SERPINE1	V		V		V			V		V
C3	V
SERPINA1	V			V		V	V		V		V
PLAU		V
CD55		V	V							V		V	V
PROC		V					V			V		V
CFD		V			V		V			V
F2R			V
CLU							V		V					V
MBL2								V			V			V
CD46								V						V
F3								V	V		V
PROS1									V		V
C1QA											V
SERPINB2													V
CD59														V
ITGB2														V
+ 04611: Platelet activation	0.3	0.2	0.1	1.2	0.2	0.8	0.3	0.3	0.1	0	1.9	0	0.7	0.3
ITGB1	V			V		V					V			V
ROCK1	V					V
GNAI2	V			V		V		V
GNAS	V						V						V
PIK3R2		V
RHOA		V	V				V		V		V			V
PRKACB		V		V	V								V
FYN		V									V
F2R			V
PPP1CB			V
ARHGEF1				V
PPP1R12A				V		V
MYL12A				V
SNAP23				V										V
PLCB3					V						V		V
RAP1A					V		V			V			V
ITGA2						V						V
ADCY7						V								V
MAPK14							V
ROCK2								V	V		V
PPP1CA								V			V
GNAI3								V			V
PIK3CA											V
MAPK12											V		V
AKT3													V
ARHGEF12													V
+ 04620: Toll-like receptor signaling pathway	2.7	0.9	0.7	1.5	0.9	0.7	0.7	0.1	0.9	0	0.5	0.1	0.7	1
MYD88	V					V			V					V
NFKB1	V				V				V
TRAF3	V			V		V
CXCL8	V
MAPK8	V			V				V			V
IL1B	V												V
IL6	V					V								V
STAT1	V			V	V				V
NFKBIA	V
MAP2K7	V			V		V
CTSK	V			V
IRAK1		V		V		V			V
IRF7		V		V			V
MAP3K7		V	V											V
TMED7-TICAM2		V	V									V		V
IKBKG		V	V		V		V							V
PIK3R2		V
IKBKB			V		V		V						V
CASP8			V					V	V			V	V
MAPK9					V									V
CHUK							V
MAPK14							V
MAPK12											V		V
TOLLIP											V
PIK3CA											V
RAC1													V
AKT3													V
+ 04621: NOD-like receptor signaling pathway	3.9	0.7	2.2	2.5	1.2	2.3	1.5	1.1	0.9	0.6	0.6	0.6	1.2	2
IL1B	V												V
SUGT1	V		V			V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
MAPK8	V			V				V			V
NFKB1	V				V				V
TRAF3	V			V		V
STAT1	V			V	V				V
GSDMD	V			V		V
MYD88	V					V			V					V
NFKBIA	V
BIRC2	V
IFI16	V			V									V
TNFAIP3	V					V						V
CTSB	V			V		V
IL6	V					V								V
CXCL8	V
CXCL1	V
CXCL2	V
CXCL3	V
MAP3K7		V	V											V
IKBKG		V	V		V		V							V
IRF7		V		V			V
RHOA		V	V				V		V		V			V
MAVS		V	V					V		V		V	V
NEK7		V	V		V			V	V		V
RBCK1		V	V
CARD6		V	V		V
MFN1		V					V			V				V
IKBKB			V		V		V						V
VDAC2			V							V	V
BIRC3			V
ATG5			V				V					V	V
NAMPT			V				V			V			V
CASP8			V					V	V			V	V
MCU				V
ERBIN				V		V		V					V
TANK				V	V					V
TRAF2				V
BCL2L1				V		V								V
MAPK9					V									V
PLCB3					V						V		V
XIAP						V						V
RNF31						V
ATG12						V				V
TRAF5						V
CHUK							V
MAPK14							V
VDAC3							V			V		V
PANX1								V
TXNIP								V						V
PRKCD								V	V
MAPK12											V		V
BRCC3												V		V
NLRP3													V
TRIP6													V
IL18														V
+ 04622: RIG-I-like receptor signaling pathway	2.1	1.2	2.1	1.9	1.9	0.6	2.6	0.6	0.3	1.3	0.6	1.3	1	1.3
NFKB1	V				V				V
TRAF3	V			V		V
NFKBIA	V
SIKE1	V									V		V		V
DDX3X	V			V		V								V
MAPK8	V			V				V			V
CXCL8	V
MAVS		V	V					V		V		V	V
IRF7		V		V			V
TBKBP1		V
IKBKG		V	V		V		V							V
MAP3K7		V	V											V
CASP8			V					V	V			V	V
IKBKB			V		V		V						V
ATG5			V				V					V	V
CYLD			V		V					V		V
TANK				V	V					V
TRAF2				V
MAPK9					V									V
ATG12						V				V
IFIH1							V
AZI2							V				V
CHUK							V
MAPK14							V
MAPK12											V		V
+ 04623: Cytosolic DNA-sensing pathway	1	0.9	1.4	0.4	1.7	0.1	2.4	0.4	0.4	1	0	1	1.2	1
IL1B	V												V
NFKB1	V				V				V
IL6	V					V								V
NFKBIA	V
IRF7		V		V			V
MAVS		V	V					V		V		V	V
IKBKG		V	V		V		V							V
POLR3H		V	V									V
ADAR			V				V			V		V
IKBKB			V		V		V						V
POLR2H				V	V								V
POLR2E					V		V			V		V		V
CHUK							V
POLR1D							V			V			V
POLR3B								V	V
IL18														V
+ 04625: C-type lectin receptor signaling pathway	3.4	0.9	1.7	1.2	1.6	1.4	2.5	1.2	2	0.4	1.6	0.2	2.6	2.1
NFKB1	V				V				V
NRAS	V					V
PTPN11	V			V		V			V
IL1B	V												V
IL6	V					V								V
STAT1	V			V	V				V
NFKBIA	V
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
IRF1	V					V	V						V
NFKB2	V			V										V
MAPK8	V			V				V			V
IKBKG		V	V		V		V							V
RHOA		V	V				V		V		V			V
MALT1		V	V					V	V					V
MAP3K14		V	V					V
PIK3R2		V
CALM2		V	V		V		V		V		V		V
IKBKB			V		V		V						V
CASP8			V					V	V			V	V
CYLD			V		V					V		V
HRAS				V			V			V		V		V
MAPK9					V									V
IL23A						V
CHUK							V
PPP3CC							V			V				V
MAPK14							V
PLK3								V
PRKCD								V	V
PAK1											V
PIK3CA											V
MAPK12											V		V
NLRP3													V
ARHGEF12													V
CLEC1B													V
AKT3													V
PTGS2													V
+ 04650: Natural killer cell mediated cytotoxicity	1.2	0.2	0.1	1.1	0.6	0.7	0.7	0.1	0.9	0.2	1.8	0.2	1.4	0.7
NFATC2	V						V							V
PPP3CB	V			V		V					V		V
HLA-E	V			V		V		V	V		V		V
CSF2	V											V
PTPN11	V			V		V			V
ICAM1	V
NRAS	V					V
SHC1	V			V									V
FYN		V									V
HLA-C		V	V		V		V			V			V
HLA-B		V				V				V		V		V
PIK3R2		V
CASP3			V					V			V
MICB			V		V		V		V		V		V
PLCG1				V
MICA				V							V
HRAS				V			V			V		V		V
SH3BP2					V		V					V	V
TNFRSF10A					V
HLA-A					V				V		V
ARAF						V
PPP3CC							V			V				V
PTPN6								V	V					V
SOS2									V				V
PIK3CA											V
PAK1											V
IFNGR2													V
RAC1													V
RAC3													V
ITGB2														V
+ 04612: Antigen processing and presentation	3.5	1.4	1.5	3.3	2.2	1.6	2.4	0.2	1.8	1.5	1.3	0.8	0.8	2.4
NFYC	V			V										V
CTSB	V			V		V
CTSS	V				V
HLA-E	V			V		V		V	V		V		V
HLA-DRB1	V		V		V				V		V
TAP2	V			V		V	V		V			V
CANX	V			V			V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
HSPA1B	V			V		V	V			V				V
PSME3	V						V			V		V	V
RFXANK		V
IFI30		V	V		V
TAPBP		V	V		V		V		V					V
HLA-B		V				V				V		V		V
HLA-C		V	V		V		V			V			V
HSPA1A		V												V
CD74			V		V								V
LGMN			V
CREB1				V										V
HLA-DPA1				V
HLA-A					V				V		V
RFX5							V			V			V
HLA-DRA											V
+ 04660: T cell receptor signaling pathway	2.1	2.3	1.4	0.9	0.9	0.5	2.2	0.6	1	0.2	1.3	0.1	0.7	2.5
CSF2	V											V
NFKBIA	V
NFKB1	V				V				V
NRAS	V					V
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
MAP2K7	V			V		V
GSK3B	V			V
IKBKG		V	V		V		V							V
MAP3K14		V	V					V
MALT1		V	V					V	V					V
PIK3R2		V
RHOA		V	V				V		V		V			V
PAK4		V					V						V
BUB1B-PAK6		V
PAK6		V
FYN		V									V
MAP3K7		V	V											V
IKBKB			V		V		V						V
PDPK1			V		V			V						V
HRAS				V			V			V		V		V
PLCG1				V
MAPK9					V									V
CHUK							V
PPP3CC							V			V				V
MAPK14							V
PTPN6								V	V					V
SOS2									V				V
PIK3CA											V
PAK1											V
MAPK12											V		V
AKT3													V
+ 04658: Th1 and Th2 cell differentiation	2.3	0	0.3	1.4	1.5	0.3	1.3	0.1	0.7	0.1	1.4	0	0.3	0.9
NFKBIA	V
NFKB1	V				V				V
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
MAPK8	V			V				V			V
STAT1	V			V	V				V
STAT5A	V			V										V
HLA-DRB1	V		V		V				V		V
IKBKG		V	V		V		V							V
IKBKB			V		V		V						V
PLCG1				V
HLA-DPA1				V
MAPK9					V									V
STAT5B						V
CHUK							V
PPP3CC							V			V				V
MAPK14							V
RBPJ								V			V
GATA3									V
MAPK12											V		V
HLA-DRA											V
IFNGR2													V
+ 04659: Th17 cell differentiation	3.7	0.3	1.3	1.8	1.6	1.4	1.7	0.5	1.2	1	1.9	0.2	0.9	1.7
NFKBIA	V
NFKB1	V				V				V
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
MAPK8	V			V				V			V
STAT1	V			V	V				V
STAT5A	V			V										V
HLA-DRB1	V		V		V				V		V
IL1B	V												V
IL6	V					V								V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
HIF1A	V					V			V		V
IKBKG		V	V		V		V							V
IL1RAP		V										V	V
IRF4		V	V		V							V
RUNX1		V	V				V
IKBKB			V		V		V						V
IL1R1			V
RXRB			V					V
PLCG1				V
HLA-DPA1				V
MAPK9					V									V
STAT5B						V
IL23A						V
CHUK							V
PPP3CC							V			V				V
MAPK14							V
SMAD2								V		V	V
GATA3									V
MTOR										V
AHR										V
MAPK12											V		V
HLA-DRA											V
IFNGR2													V
IL6ST													V
+ 04657: IL-17 signaling pathway	5.3	0.4	1.5	1.7	0.7	1.6	1.3	1	1.5	0.1	2.2	0.5	2.2	1.2
IL6	V					V								V
NFKBIA	V
NFKB1	V				V				V
TRAF3	V			V		V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
SRSF1	V					V			V				V
MAPK8	V			V				V			V
GSK3B	V			V
CXCL1	V
CXCL2	V
CXCL3	V
TNFAIP3	V					V						V
CXCL8	V
CSF2	V											V
LCN2	V
CSF3	V									V
IL1B	V												V
MAP3K7		V	V											V
IKBKG		V	V		V		V							V
FOSL1		V	V
IL17RC		V	V					V					V
IKBKB			V		V		V						V
CASP3			V					V			V
CASP8			V					V	V			V	V
TRAF2				V
ELAVL1				V
MAPK9					V									V
IL17RA						V
TRAF5						V
CHUK							V
MAPK14							V
ANAPC5							V
S100A8									V		V		V
S100A9									V		V		V
TRAF3IP2											V
MAPK12											V		V
USP25											V
MMP3													V
PTGS2													V
+ 04662: B cell receptor signaling pathway	1.9	0.6	0.7	0.5	0.9	0.4	1.5	0.5	0.9	0.4	0.2	0	1.5	1.5
NFKBIA	V
NFKB1	V				V				V
GSK3B	V			V
NRAS	V					V
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
IKBKG		V	V		V		V							V
MALT1		V	V					V	V					V
PIK3R2		V
IFITM1		V	V		V			V					V
IKBKB			V		V		V						V
HRAS				V			V			V		V		V
CHUK							V
PPP3CC							V			V				V
PTPN6								V	V					V
SOS2									V				V
PIK3CA											V
AKT3													V
RAC1													V
RAC3													V
+ 04664: Fc epsilon RI signaling pathway	1.4	0.2	0.1	1.5	0.3	0.3	0.3	0.7	0.1	0.1	1.1	0.3	1.1	0.6
CSF2	V											V
MAP2K7	V			V		V
NRAS	V					V
MAPK8	V			V				V			V
ALOX5	V			V
FYN		V									V
PIK3R2		V
PDPK1			V		V			V						V
PLCG1				V
HRAS				V			V			V		V		V
MAPK9					V									V
MAPK14							V
GAB2								V
SOS2									V				V
MAPK12											V		V
PIK3CA											V
AKT3													V
RAC1													V
RAC3													V
+ 04666: Fc gamma R-mediated phagocytosis	1.2	0.4	0.5	1.4	0.7	0.6	0.6	0.7	0.7	0.5	0.7	0	0.3	1.2
ARPC2	V			V
CRK	V		V		V		V			V				V
ASAP1	V			V		V			V
ASAP2	V			V			V					V
PIP5K1A	V		V					V	V		V			V
BIN1	V		V		V
PIK3R2		V
LIMK1		V
GSN		V					V			V				V
DNM2		V			V					V
ASAP3			V		V									V
PLCG1				V
RPS6KB1				V		V				V
MYO10				V		V	V							V
ARF6						V								V
PRKCD								V	V
PLPP1								V	V				V
GAB2								V
PIK3CA											V
PAK1											V
SPHK1											V
AKT3													V
RAC1													V
SPHK2													V
+ 04670: Leukocyte transendothelial migration	1.2	0.7	0.3	1.7	0.5	1	0.9	0.7	1.5	0.9	1.8	0.3	1.8	0.6
CLDN4	V			V		V					V		V
PTPN11	V			V		V			V
CTNND1	V			V		V		V	V					V
ITGB1	V			V		V					V			V
ROCK1	V					V
GNAI2	V			V		V		V
ICAM1	V
BCAR1		V							V				V
PIK3R2		V
RHOA		V	V				V		V		V			V
ARHGAP5		V			V
CTNNA1		V	V
VCL		V	V		V							V
CD99			V		V			V			V		V
MYL12A				V
PXN				V									V
PLCG1				V
RAP1A					V		V			V			V
PTK2							V			V		V		V
MAPK14							V
RASSF5							V						V
CXCR4							V			V		V
ROCK2								V	V		V
GNAI3								V			V
AFDN									V
CXCL12									V
CLDN15										V
F11R										V
NCF2										V		V
PIK3CA											V
MAPK12											V		V
CLDN7													V
ESAM													V
RAC1													V
ITGB2														V
+ 04672: Intestinal immune network for IgA production	0.9	0.1	0.5	0.6	0.6	0.2	0.5	0.2	1.1	0.5	0.6	0.5	0.1	0.1
IL6	V					V								V
HLA-DRB1	V		V		V				V		V
ICOSLG	V				V
MAP3K14		V	V					V
HLA-DPA1				V
LTBR				V					V				V
TNFSF13B							V			V		V
CXCR4							V			V		V
CXCL12									V
HLA-DRA											V
+ 04062: Chemokine signaling pathway	2	0.1	0	0.7	0.8	0.2	1	0.2	1.1	0.2	0.5	0	1	0.5
CXCL1	V
CXCL2	V
CXCL3	V
CXCL8	V
CCL13	V			V		V				V
SHC1	V			V									V
GNAI2	V			V		V		V
CRK	V		V		V		V			V				V
ROCK1	V					V
STAT1	V			V	V				V
NRAS	V					V
NFKB1	V				V				V
NFKBIA	V
GSK3B	V			V
RHOA		V	V				V		V		V			V
PIK3R2		V
BCAR1		V							V				V
PRKACB		V		V	V								V
IKBKG		V	V		V		V							V
IKBKB			V		V		V						V
PXN				V									V
HRAS				V			V			V		V		V
PLCB3					V						V		V
RAP1A					V		V			V			V
ADCY7						V								V
STAT5B						V
CXCR4							V			V		V
PTK2							V			V		V		V
ARRB1							V					V
CHUK							V
GNAI3								V			V
ARRB2								V	V		V
ROCK2								V	V		V
PRKCD								V	V
CXCL12									V
SOS2									V				V
PIK3CA											V
PAK1											V
GNB1													V
AKT3													V
RAC1													V
RAC3													V
GNG10														V
GNB4														V
+ 5.2 Endocrine system	5.8	3.7	2	7.3	3.9	4.5	4.2	3.7	3	1.7	3.7	0.8	5.9	4.8
+ 04911: Insulin secretion	0.6	1.6	0.3	1.9	0.8	0.4	1.4	0	0.5	0	0	0	1	0.3
GNAS	V						V						V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
PRKACB		V		V	V								V
GNA11		V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
STX1A		V	V
VAMP2		V	V		V
GCK				V		V
CREB1				V										V
ATF2				V		V	V						V
PLCB3					V						V		V
ADCY7						V								V
+ 04910: Insulin signaling pathway	1.4	1.5	1.1	2.9	3	2.2	0.9	1	0	0.8	0.8	0.2	1.6	2.1
MAPK8	V			V				V			V
SOCS1	V					V
PRKAA1	V			V
PHKB	V					V
PRKAR2A	V					V
NRAS	V					V
SHC1	V			V									V
GSK3B	V			V
CRK	V		V		V		V			V				V
PTPN1		V	V		V			V						V
CALM2		V	V		V		V		V		V		V
PRKACB		V		V	V								V
PRKAR1A		V			V		V			V		V	V
ACACA		V		V						V	V			V
TRIP10		V									V
TSC2		V			V			V		V
FBP1		V
EXOC7		V		V		V						V		V
PIK3R2		V
IKBKB			V		V		V						V
PPP1CB			V
PCK2			V		V		V							V
G6PC3			V		V			V						V
PDPK1			V		V			V						V
PRKAG2				V		V
HRAS				V			V			V		V		V
EIF4E				V		V
RPS6KB1				V		V				V
SREBF1				V	V									V
GCK				V		V
MAPK9					V									V
RHOQ					V
SOCS2						V
ARAF						V
PRKAB2							V					V	V
SOCS4								V
PPP1CA								V			V
SOS2									V				V
MTOR										V
PIK3CA											V
TSC1													V
ELK1													V
AKT3													V
FLOT1													V
MKNK2														V
+ 04922: Glucagon signaling pathway	1	1.2	1.4	2.3	1.3	1.5	1.4	0.9	0.3	0.4	1.2	0.1	2.6	2.1
GNAS	V						V						V
CREBBP	V					V		V			V		V
PHKB	V					V
PPP3CB	V			V		V					V		V
PRKAA1	V			V
LDHA	V						V			V
PRKACB		V		V	V								V
CREB3		V											V
CREB3L4		V											V
PPP4R3B		V						V
CALM2		V	V		V		V		V		V		V
FBP1		V
ACACA		V		V						V	V			V
PKM			V		V			V	V				V
PCK2			V		V		V							V
G6PC3			V		V			V						V
SIK1B			V											V
SIK1			V											V
CPT1C			V					V	V		V
GCK				V		V
CREB1				V										V
ATF2				V		V	V						V
CRTC2				V		V
PRKAG2				V		V
PLCB3					V						V		V
PPP3CC							V			V				V
PRKAB2							V					V	V
CPT1A										V		V
AKT3													V
PPP4C														V
SIRT1														V
+ 04923: Regulation of lipolysis in adipocytes	0.4	0.3	0	0.9	0.1	1.3	0.1	0.5	0.2	0.1	0.5	0	1.4	0.1
GNAS	V						V						V
GNAI2	V			V		V		V
PRKACB		V		V	V								V
PIK3R2		V
MGLL				V		V				V
ADCY7						V								V
PLAAT3						V							V
GNAI3								V			V
PLIN1									V
PIK3CA											V
PTGS2													V
AKT3													V
+ 04920: Adipocytokine signaling pathway	1.7	0.5	2.1	1.9	2.4	0.3	2.2	1.9	1.1	0.5	0.3	0.2	0.4	2.2
NFKB1	V				V				V
NFKBIA	V
PTPN11	V			V		V			V
PRKAA1	V			V
ADIPOR1	V			V				V
MAPK8	V			V				V			V
ACSL1		V			V		V			V				V
ADIPOR2		V	V				V							V
IKBKG		V	V		V		V							V
CPT1C			V					V	V		V
G6PC3			V		V			V						V
PCK2			V		V		V							V
RXRB			V					V
IKBKB			V		V		V						V
PRKAG2				V		V
TRAF2				V
MAPK9					V									V
PRKAB2							V					V	V
CHUK							V
ACSL5								V	V
CPT1A										V		V
MTOR										V
AKT3													V
CAMKK2														V
+ 03320: PPAR signaling pathway	0	0.4	1.2	0.5	1	1.3	0.2	2.2	2.3	0.2	1.4	0	0.3	0.8
ACADM	V				V						V
ACAA1		V				V			V
ACSL1		V			V		V			V				V
ACOX1		V
PCK2			V		V		V							V
RXRB			V					V
PPARD			V			V		V	V		V
CPT1C			V					V	V		V
PDPK1			V		V			V						V
GK				V		V
FADS2				V
DBI				V
SCP2						V					V		V
ILK						V
ACSL5								V	V
ANGPTL4								V
APOA1								V	V		V			V
PLIN1									V
APOC3									V
CPT1A										V		V
PPARG													V
SCD													V
+ 04912: GnRH signaling pathway	0.9	0.2	0.1	0.6	0.7	0.6	0.6	0.7	0.7	0	1	0	1.2	0.6
GNAS	V						V						V
NRAS	V					V
EGFR	V					V		V	V		V
MAP2K7	V			V		V
MAPK8	V			V				V			V
CALM2		V	V		V		V		V		V		V
GNA11		V
PRKACB		V		V	V								V
MAP3K3			V					V						V
HRAS				V			V			V		V		V
PLCB3					V						V		V
MAPK9					V									V
ADCY7						V								V
MAPK14							V
PRKCD								V	V
SOS2									V				V
MAPK12											V		V
ELK1													V
+ 04913: Ovarian steroidogenesis	1.4	0.1	0	1.5	0.2	0.5	0.1	0.5	0	0.1	0.2	0	0.7	0.9
GNAS	V						V						V
HSD17B1	V			V
LDLR	V			V		V		V						V
ALOX5	V			V
PRKACB		V		V	V								V
ADCY7						V								V
CYP1A1								V			V
SCARB1										V
PTGS2													V
CYP1B1														V
+ 04915: Estrogen signaling pathway	1.1	1.2	0	1.6	0.8	1.2	1.5	0.7	1.1	0.2	0.8	0.2	3	1.4
EGFR	V					V		V	V		V
NRAS	V					V
SHC1	V			V									V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
HSPA1B	V			V		V	V			V				V
GNAS	V						V						V
GNAI2	V			V		V		V
PRKACB		V		V	V								V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
PIK3R2		V
FKBP5		V			V
HSPA1A		V												V
CALM2		V	V		V		V		V		V		V
KRT17		V										V
HRAS				V			V			V		V		V
CREB1				V										V
ATF2				V		V	V						V
PLCB3					V						V		V
NCOA1					V				V
ADCY7						V								V
TGFA						V	V						V
NCOA2							V
PRKCD								V	V
GNAI3								V			V
KRT15								V						V
SOS2									V				V
NCOA3									V				V
PIK3CA											V
AKT3													V
FKBP4													V
KRT13													V
KRT14													V
KRT16													V
+ 04914: Progesterone-mediated oocyte maturation	2.3	2.4	0.5	1.7	0.4	1.2	1.2	3.2	0.4	2.3	1.4	0.5	1.5	2.3
CPEB4	V			V		V
CDK1	V		V							V				V
ANAPC11	V			V		V		V		V		V	V
CDC25B	V							V		V				V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
GNAI2	V			V		V		V
CDK2	V							V		V
MAPK8	V			V				V			V
PIK3R2		V
ANAPC2		V
CDC16		V						V	V				V
CDC27		V						V						V
FZR1		V
MAD1L1		V	V				V			V		V
PRKACB		V		V	V								V
PKMYT1		V						V						V
RPS6KA1		V
AURKA		V	V		V			V		V	V			V
CDC25A			V				V			V
MAPK9					V									V
ADCY7						V								V
ARAF						V
ANAPC4							V			V		V	V
ANAPC5							V
MAPK14							V
GNAI3								V			V
PLK1									V				V
PIK3CA											V
MAPK12											V		V
AKT3													V
CCNA1													V
+ 04917: Prolactin signaling pathway	2.9	0	0	2.3	0.7	1.8	0.6	0.6	0.7	0.1	0.6	0.1	1	0.5
NRAS	V					V
STAT1	V			V	V				V
STAT5A	V			V										V
SHC1	V			V									V
MAPK8	V			V				V			V
SOCS1	V					V
IRF1	V					V	V						V
GSK3B	V			V
NFKB1	V				V				V
PIK3R2		V
HRAS				V			V			V		V		V
GCK				V		V
MAPK9					V									V
STAT5B						V
SOCS2						V
MAPK14							V
SOCS4								V
SOCS7								V
SOS2									V				V
PIK3CA											V
MAPK12											V		V
AKT3													V
+ 04921: Oxytocin signaling pathway	1.8	0.1	0.1	1.4	0.1	1.6	1	0.3	0.4	0.1	1.2	0	1	0.9
GNAS	V						V						V
NRAS	V					V
ROCK1	V					V
PRKAA1	V			V
MAP2K5	V			V										V
PPP3CB	V			V		V					V		V
NFATC2	V						V							V
NFATC3	V					V				V
RCAN1	V
GNAI2	V			V		V		V
EGFR	V					V		V	V		V
CALM2		V	V		V		V		V		V		V
PRKACB		V		V	V								V
MYL6B		V					V			V		V	V
RHOA		V	V				V		V		V			V
PPP1CB			V
CACNB1			V										V
HRAS				V			V			V		V		V
CAMK1				V		V			V
PPP1R12A				V		V
PRKAG2				V		V
PLCB3					V						V		V
ADCY7						V								V
PRKAB2							V					V	V
PPP3CC							V			V				V
ROCK2								V	V		V
PPP1CA								V			V
GNAI3								V			V
PTGS2													V
ELK1													V
CAMKK2														V
CDKN1A														V
+ 04926: Relaxin signaling pathway	1.6	0.5	0	1.4	0.9	0.7	1	0.8	0.6	0.1	1.8	0.1	1.7	1.3
NFKBIA	V
NFKB1	V				V				V
GNAS	V						V						V
GNAI2	V			V		V		V
NRAS	V					V
SHC1	V			V									V
MAP2K7	V			V		V
MAPK8	V			V				V			V
EGFR	V					V		V	V		V
PIK3R2		V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
PRKACB		V		V	V								V
VEGFA		V			V
CREB1				V										V
ATF2				V		V	V						V
HRAS				V			V			V		V		V
PLCB3					V						V		V
MAPK9					V									V
ADCY7						V								V
COL4A5							V		V					V
MAPK14							V
ARRB1							V					V
GNAI3								V			V
SMAD2								V		V	V
ARRB2								V	V		V
SOS2									V				V
PIK3CA											V
ACTA2											V
MAPK12											V		V
AKT3													V
GNB1													V
GNG10														V
GNB4														V
+ 04918: Thyroid hormone synthesis	1.2	1.5	0.8	2.2	0.6	0.2	2.5	0.1	1	0.5	0.1	0.8	1.6	0.5
GNAS	V						V						V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
CANX	V			V			V
PRKACB		V		V	V								V
TTF1		V	V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
GPX1		V	V
GSR			V					V	V
CREB1				V										V
ATF2				V		V	V						V
PLCB3					V						V		V
ADCY7						V								V
PAX8							V			V		V
TTF2										V		V	V
GPX8												V
+ 04919: Thyroid hormone signaling pathway	3.4	0.7	0.8	2.3	1.4	1.2	1.2	0.7	1.4	1.1	1	0.8	0.5	1.4
GSK3B	V			V
NRAS	V					V
STAT1	V			V	V				V
RCAN1	V
HIF1A	V					V			V		V
TP53	V		V									V		V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
HDAC2	V											V
CREBBP	V					V		V			V		V
MED13L	V										V
MED27	V
MED12	V		V									V		V
PIK3R2		V
THRA		V	V			V	V
PRKACB		V		V	V								V
MED16		V
MED13		V	V		V		V			V			V
TSC2		V			V			V		V
PDPK1			V		V			V						V
RXRB			V					V
ITGAV				V		V		V		V
PLCG1				V
HRAS				V			V			V		V		V
SIN3A				V						V		V		V
PLCB3					V						V		V
NCOA1					V				V
PFKFB2						V				V		V
NCOR1						V
NCOA2							V
NCOA3									V				V
MTOR										V
PIK3CA											V
ATP2A2											V			V
AKT3													V
SLC16A2														V
BMP4														V
+ 04928: Parathyroid hormone synthesis, secretion and action	0.4	1.5	0.4	0.8	0.3	1.1	0.7	0.8	0.9	0.4	1.2	0.1	1	1
GNAS	V						V						V
GNAI2	V			V		V		V
EGFR	V					V		V	V		V
LRP5	V					V
GNA11		V
PRKACB		V		V	V								V
RHOA		V	V				V		V		V			V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
RUNX2		V							V					V
FGFR1		V
MEF2A			V
RXRB			V					V
ARHGEF1				V
CREB1				V										V
ATF2				V		V	V						V
PLCB3					V						V		V
ADCY7						V								V
ARAF						V
ARRB1							V					V
GNAI3								V			V
ARRB2								V	V		V
GATA3									V
VDR										V
ARHGEF11										V
CYP27B1										V
MEF2D											V		V
CDKN1A														V
+ 04916: Melanogenesis	1.8	0.6	0	1.6	0.3	1.1	0.2	0.9	0	0	0.9	0	1.4	0.5
MITF	V
GNAI2	V			V		V		V
FZD6	V			V		V		V			V		V
CREBBP	V					V		V			V		V
GNAS	V						V						V
GSK3B	V			V
WNT5B	V			V		V
NRAS	V					V
PRKACB		V		V	V								V
CALM2		V	V		V		V		V		V		V
CREB3		V											V
CREB3L4		V											V
WNT9A		V
CREB1				V										V
HRAS				V			V			V		V		V
PLCB3					V						V		V
ADCY7						V								V
GNAI3								V			V
WNT3								V
TCF7L1														V
+ 04924: Renin secretion	0.9	0.2	0.1	1.5	0.7	0.6	0.6	0.3	0.1	0.1	1.1	0	1.4	0.5
GNAS	V						V						V
GNAI2	V			V		V		V
CTSB	V			V		V
PPP3CB	V			V		V					V		V
PRKACB		V		V	V								V
CALM2		V	V		V		V		V		V		V
CREB1				V										V
PLCB3					V						V		V
PPP3CC							V			V				V
GNAI3								V			V
PTGER2													V
EDN2														V
+ 04614: Renin-angiotensin system	0.5	0	0	0	0	0.5	0	0	0	0.5	0	0.5	0.4	0
CTSA	V					V				V		V	V
+ 04925: Aldosterone synthesis and secretion	1.1	1	0.1	2.4	0.6	0.5	1.5	0.3	1.8	0.2	0.3	0.1	1.4	0.5
GNAS	V						V						V
PRKD2	V			V				V	V				V
LDLR	V			V		V		V						V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
GNA11		V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
CALM2		V	V		V		V		V		V		V
PRKACB		V		V	V								V
CREB1				V										V
ATF2				V		V	V						V
CAMK1				V		V			V
PLCB3					V						V		V
ADCY7						V								V
NR4A1								V	V		V
PRKD3										V		V
SCARB1										V
+ 04927: Cortisol synthesis and secretion	0.3	1.7	0.1	1.6	1.6	1	0.6	0.7	0.4	0.3	1.2	0.1	1.9	1.9
GNAS	V						V						V
LDLR	V			V		V		V						V
GNA11		V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
PDE8A		V		V	V						V		V
PRKACB		V		V	V								V
CREB1				V										V
ATF2				V		V	V						V
PLCB3					V						V		V
NCEH1					V			V	V		V			V
ADCY7						V								V
NR5A1						V								V
NR4A1								V	V		V
SCARB1										V
+ 5.3 Circulatory system	1.2	0.6	0.6	2	0.9	0.2	1.9	0.3	1.3	0.1	1.6	0.1	1.2	0.9
+ 04260: Cardiac muscle contraction	1.4	0	0	1.5	0.2	0	1.4	0	1.2	0.1	0.8	0	0.2	0.3
TPM1	V			V			V
TPM3	V			V	V			V	V		V			V
SLC9A6	V						V			V		V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
CACNB1			V										V
TPM2				V					V
TPM4					V						V
COX7A2							V			V	V		V
ATP2A2											V			V
COX7B2													V
ASPH														V
+ 04261: Adrenergic signaling in cardiomyocytes	0.7	0.6	0.9	1.8	1.2	0.1	1.6	0.2	0.7	0	1.2	0	1.4	1
TPM1	V			V			V
TPM3	V			V	V			V	V		V			V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
GNAS	V						V						V
GNAI2	V			V		V		V
PRKACB		V		V	V								V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
PPP2R5C		V	V		V		V							V
PPP2R5E		V	V		V									V
CALM2		V	V		V		V		V		V		V
CACNB1			V										V
PPP1CB			V
PPP2R3B			V
PPP2R1A			V							V		V	V
TPM2				V					V
CREB1				V										V
ATF2				V		V	V						V
TPM4					V						V
PLCB3					V						V		V
ADCY7						V								V
MAPK14							V
GNAI3								V			V
PPP1CA								V			V
ATP2A2											V			V
MAPK12											V		V
PPP2R3A												V
AKT3													V
PPP2R2D														V
+ 04270: Vascular smooth muscle contraction	0	0.5	0.1	0.1	0.1	0.2	0.2	0.3	0.3	0.1	0.8	0	0.6	0.2
ROCK1	V					V
GNAS	V						V						V
MYL6B		V					V			V		V	V
RHOA		V	V				V		V		V			V
GNA11		V
CALM2		V	V		V		V		V		V		V
ADORA2A		V
PRKACB		V		V	V								V
PPP1CB			V
PPP1R12A				V		V
ARHGEF1				V
PLCB3					V						V		V
ARAF						V
ADCY7						V								V
PPP1CA								V			V
ROCK2								V	V		V
PRKCD								V	V
CALD1								V		V		V		V
ARHGEF11										V
ACTA2											V
ARHGEF12													V
ADORA2B													V
EDN2														V
+ 5.4 Digestive system	2.2	0.7	0.3	3	1.8	0.5	2.8	1.8	4	1.3	1.9	0.1	1.3	1.5
+ 04970: Salivary secretion	0.6	0.5	0.3	0.7	1.1	0	1	0	1.2	0	0.2	0	1	0.1
GNAS	V						V						V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
PRKACB		V		V	V								V
VAMP2		V	V		V
CALM2		V	V		V		V		V		V		V
SLC4A2		V			V									V
CST3			V					V	V
PLCB3					V						V		V
ADCY7						V								V
CST2													V
CST4													V
+ 04971: Gastric acid secretion	1.2	0.4	0	1.3	1	0.2	1.2	0.2	1	0	0.6	0	0.6	0.2
GNAS	V						V						V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
GNAI2	V			V		V		V
PRKACB		V		V	V								V
SLC4A2		V			V									V
CALM2		V	V		V		V		V		V		V
PLCB3					V						V		V
ADCY7						V								V
GNAI3								V			V
+ 04972: Pancreatic secretion	0.5	0.1	0	0.3	0.4	0	1.2	0	0.7	0	0.3	0	0.5	0.5
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
GNAS	V						V						V
SLC4A2		V			V									V
RHOA		V	V				V		V		V			V
PLCB3					V						V		V
RAP1A					V		V			V			V
ADCY7						V								V
ATP2A2											V			V
CEL													V
RAC1													V
+ 04976: Bile secretion	1.3	0.7	0	1.4	1	0.2	0.9	1	1.9	0	0.6	0	0.1	0.9
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
GNAS	V						V						V
LDLR	V			V		V		V						V
SLC4A2		V			V									V
PRKACB		V		V	V								V
EPHX1		V							V		V
ABCC4		V						V
HMGCR					V
NCEH1					V			V	V		V			V
ADCY7						V								V
ABCC3								V	V		V
SCARB1										V
+ 04973: Carbohydrate digestion and absorption	1	0.1	0.2	1.1	0.7	0.2	1.1	0.2	1.2	0	0.6	0	0.4	0.2
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
PIK3R2		V
G6PC3			V		V			V						V
SLC37A4					V								V
MGAM						V					V
PIK3CA											V
AKT3													V
+ 04974: Protein digestion and absorption	0.3	0.1	0	1	0.2	0.1	1	0	1.1	0	0	0	0	0.3
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
SLC7A7		V			V
COL5A1		V	V		V					V				V
COL6A1				V
COL7A1				V		V			V
COL13A1						V							V
SLC7A8							V
COL4A5							V		V					V
COL27A1														V
+ 04975: Fat digestion and absorption	0	0	0	0	0.3	0	0.2	0.7	0.8	0.6	0.3	0	0.5	1.2
DGAT1					V					V				V
AGPAT1							V
APOA1								V	V		V			V
PLPP1								V	V				V
SCARB1										V
CEL													V
AGPAT2														V
+ 04979: Cholesterol metabolism	0.5	0	0.1	0.6	0.6	0.2	1	2.5	2.1	2.4	2.1	0.1	0.7	0.9
LDLR	V			V		V		V						V
NPC1	V						V			V
VDAC2			V							V	V
TSPO				V
APOC1					V					V
NCEH1					V			V	V		V			V
APOC2							V
VDAC3							V			V		V
APOA1								V	V		V			V
ANGPTL4								V
APOH								V	V		V
NPC2								V	V		V
APOC3									V
SCARB1										V
LRPAP1										V
LCAT													V
PCSK9													V
LIPA													V
+ 04977: Vitamin digestion and absorption	0.5	0	0	1.2	0	0.5	0	0.5	1.2	0.5	0.5	0	0.4	0.5
ABCC1	V			V		V			V				V
SLC5A6				V
APOA1								V	V		V			V
SCARB1										V
+ 04978: Mineral absorption	1.3	0.3	0.1	1.9	0.5	0.1	1.3	0.5	1.5	0.4	0.9	0.1	0	0
CYBRD1	V			V		V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
HMOX2		V	V		V							V
STEAP1		V			V			V			V
SLC11A2				V			V			V	V
ATP7A								V			V
MT1G									V
VDR										V
+ 5.5 Excretory system	4	1.3	0.7	4.4	1.6	2.1	3.2	1.3	2.5	1.1	0.9	1.1	2.2	2.6
+ 04962: Vasopressin-regulated water reabsorption	1.5	1.4	0.5	1.6	1.7	1.6	1.6	1.1	0.2	0.6	1.2	1	2.6	2
GNAS	V						V						V
ARHGDIA	V					V					V			V
RAB5C	V					V	V					V		V
DYNLL1	V			V		V
PRKACB		V		V	V								V
CREB3		V											V
CREB3L4		V											V
VAMP2		V	V		V
DCTN5			V		V		V			V		V	V
CREB1				V										V
RAB5B				V						V			V
NSF					V		V					V
STX4						V							V
DCTN1								V						V
DYNC1LI2								V						V
DYNC2H1								V	V		V
DYNC1I2											V
+ 04960: Aldosterone-regulated sodium reabsorption	1.8	0.6	0.2	1.9	0.3	0.7	1.3	0.3	1.4	0	0.3	0	0	0.2
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
NEDD4L	V			V		V
PIK3R2		V
SLC9A3R2		V				V
PDPK1			V		V			V						V
PIK3CA											V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	3.2	0.8	0	3.4	1	0.9	1.4	1.5	2.1	0.5	0.5	0	1.5	0.9
CLTA	V			V				V	V					V
CLTB	V			V		V		V						V
AP2A2	V			V		V		V	V		V			V
AP2B1	V
GNAS	V						V						V
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
CLTC		V						V					V
DNM2		V			V					V
PRKACB		V		V	V								V
AP2S1				V		V							V
PLCB3					V						V		V
VDR										V
+ 04964: Proximal tubule bicarbonate reclamation	2.4	0	0.5	2.5	0.5	0.5	3	0	1.9	1.1	0	0.5	0.4	1.8
ATP1A1	V			V			V		V
ATP1A3	V			V			V		V
ATP1A4	V			V			V		V
MDH1	V			V						V				V
PCK2			V		V		V							V
SLC25A10						V	V					V	V
GLUD1										V
SLC38A3														V
+ 04966: Collecting duct acid secretion	0	0	0.4	0.4	0	1	0	0	0	0.4	0	1	0.3	1
ATP6V0A4			V											V
SLC12A7				V		V						V		V
ATP6V1D						V						V	V
TCIRG1										V
+ 5.6 Nervous system	2.3	1.4	1.1	2.6	1.9	1.5	1.4	1.7	0.9	0.8	2.2	0.6	2.6	2.9
+ 04724: Glutamatergic synapse	0.2	0	0	0.4	0.1	0.2	0.1	0.1	0	0	0.2	0	0.3	0.6
GNAS	V						V						V
GNAI2	V			V		V		V
PPP3CB	V			V		V					V		V
PRKACB		V		V	V								V
SLC38A1				V
PLCB3					V						V		V
ADCY7						V								V
PPP3CC							V			V				V
GNAI3								V			V
GNB1													V
SLC38A3														V
GNG10														V
GNB4														V
+ 04727: GABAergic synapse	0	0	0	0.4	0.2	0.1	0	0.2	0	0	0	0	0.1	0.6
GNAI2	V			V		V		V
PRKACB		V		V	V								V
SLC38A1				V
NSF					V		V					V
ADCY7						V								V
GNAI3								V			V
GNB1													V
GNG10														V
GNB4														V
SLC38A3														V
+ 04725: Cholinergic synapse	0	0.7	0	0.4	0.1	0.2	0	0.1	0	0	0.5	0	0.6	0.6
GNAI2	V			V		V		V
NRAS	V					V
PRKACB		V		V	V								V
GNA11		V
CREB3		V											V
CREB3L4		V											V
PIK3R2		V
FYN		V									V
CREB1				V										V
HRAS				V			V			V		V		V
PLCB3					V						V		V
ADCY7						V								V
GNAI3								V			V
PIK3CA											V
GNB1													V
AKT3													V
GNG10														V
GNB4														V
+ 04728: Dopaminergic synapse	0.4	1	1.2	1.1	1.5	0.1	1.3	0.5	0	0.2	1.5	0.2	2	1.6
GNAS	V						V						V
GNAI2	V			V		V		V
GSK3B	V			V
MAPK8	V			V				V			V
PPP3CB	V			V		V					V		V
PRKACB		V		V	V								V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
COMT		V	V		V
PPP2R5C		V	V		V		V							V
PPP2R5E		V	V		V									V
CALM2		V	V		V		V		V		V		V
PPP2R3B			V
PPP2R1A			V							V		V	V
PPP1CB			V
CREB1				V										V
ATF2				V		V	V						V
PLCB3					V						V		V
MAPK9					V									V
MAPK14							V
PPP3CC							V			V				V
CLOCK							V			V		V
GNAI3								V			V
ARRB2								V	V		V
PPP1CA								V			V
MAPK12											V		V
PPP2R3A												V
GNB1													V
AKT3													V
GNG10														V
GNB4														V
PPP2R2D														V
+ 04726: Serotonergic synapse	0.3	0	0	0.4	0.1	0.2	0	0.2	0	0	0.4	0	0.3	0.1
GNAS	V						V						V
GNAI2	V			V		V		V
ALOX5	V			V
NRAS	V					V
PRKACB		V		V	V								V
APP		V									V
CASP3			V					V			V
HRAS				V			V			V		V		V
PLCB3					V						V		V
ARAF						V
GNAI3								V			V
GNB1													V
PTGS2													V
GNG10														V
GNB4														V
+ 04720: Long-term potentiation	0.6	0.5	0.2	0.7	1.1	1	1	0.3	0.1	0.6	1.6	0.1	1.4	0.3
CREBBP	V					V		V			V		V
PPP3CB	V			V		V					V		V
NRAS	V					V
CALM2		V	V		V		V		V		V		V
RPS6KA1		V
PRKACB		V		V	V								V
PPP1CB			V
HRAS				V			V			V		V		V
RAP1A					V		V			V			V
PLCB3					V						V		V
ARAF						V
PPP3CC							V			V				V
PPP1CA								V			V
+ 04730: Long-term depression	0.7	0.1	0.1	0.4	0.1	0.7	0.3	0.4	0	0.3	0.4	0.3	0.5	0.1
GNAI2	V			V		V		V
GNAS	V						V						V
NRAS	V					V
GNA11		V
PPP2R1A			V							V		V	V
HRAS				V			V			V		V		V
PLCB3					V						V		V
ARAF						V
GNAI3								V			V
+ 04723: Retrograde endocannabinoid signaling	0.3	0.1	0	0.6	0.2	0.5	0.1	0.4	0.1	0.3	0.9	0	0.8	0.5
GNAI2	V			V		V		V
MAPK8	V			V				V			V
NDUFC2-KCTD14	V		V			V	V			V
NDUFV1	V
NDUFA13	V
PRKACB		V		V	V								V
NDUFAB1		V	V		V
NDUFB6		V					V			V				V
NDUFC1		V		V				V	V		V		V
NDUFB3			V
MGLL				V		V				V
NDUFA12				V		V			V		V		V
PLCB3					V						V		V
MAPK9					V									V
ADCY7						V								V
NDUFB2						V	V			V			V
MAPK14							V
GNAI3								V			V
NDUFS5								V	V		V			V
NDUFA11										V		V	V
MAPK12											V		V
NDUFA6												V
PTGS2													V
GNB1													V
GNG10														V
GNB4														V
+ 04721: Synaptic vesicle cycle	1.1	0.6	0.4	1.3	1.3	0.8	0.2	1.3	0.3	0.8	0.1	0.4	1.2	1.9
NAPA	V						V			V		V	V
CLTA	V			V				V	V					V
CLTB	V			V		V		V						V
AP2A2	V			V		V		V	V		V			V
AP2B1	V
STX1A		V	V
VAMP2		V	V		V
CLTC		V						V					V
DNM2		V			V					V
ATP6V0A4			V											V
STX3				V
AP2S1				V		V							V
STX2					V			V						V
NSF					V		V					V
SLC6A9					V					V
ATP6V1D						V						V	V
TCIRG1										V
SYT1													V
ATP6V0B													V
SLC6A2														V
SLC6A5														V
+ 04722: Neurotrophin signaling pathway	3.7	1.2	1.4	2.6	1.4	0.9	1.5	2	2.4	0.5	1.3	0.8	1	2.8
SHC1	V			V									V
NRAS	V					V
CRK	V		V		V		V			V				V
PTPN11	V			V		V			V
GSK3B	V			V
NFKBIA	V
NFKB1	V				V				V
MAPK8	V			V				V			V
TP53	V		V									V		V
MAP3K5	V
MAP2K5	V			V										V
ARHGDIA	V					V					V			V
ABL1	V			V		V	V			V		V		V
MAP2K7	V			V		V
MAGED1	V			V								V
PIK3R2		V
RPS6KA1		V
RHOA		V	V				V		V		V			V
SH2B3		V						V	V
ZNF274		V										V
IRAK1		V		V		V			V
YWHAE		V						V	V		V			V
CALM2		V	V		V		V		V		V		V
PDPK1			V		V			V						V
MAP3K3			V					V						V
IKBKB			V		V		V						V
BAX			V					V		V		V
PLCG1				V
HRAS				V			V			V		V		V
RAP1A					V		V			V			V
MAPK9					V									V
MAPK14							V
PRKCD								V	V
SH2B1								V						V
BEX3								V	V
SOS2									V				V
PIK3CA											V
MAPK12											V		V
AKT3													V
RAC1													V
+ 5.7 Sensory system	0.1	0.5	0.3	0.2	0.7	0	0.3	0.1	0.3	0	0.9	0	1.1	0
+ 04744: Phototransduction	0	0.3	0.4	0	0.4	0	0.4	0	0.5	0	0.4	0	0.8	0
CALM2		V	V		V		V		V		V		V
GNB1													V
+ 04740: Olfactory transduction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CALM2		V	V		V		V		V		V		V
PRKACB		V		V	V								V
ARRB1							V					V
ARRB2								V	V		V
GNB1													V
+ 04742: Taste transduction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
PRKACB		V		V	V								V
+ 04750: Inflammatory mediator regulation of TRP channels	0.2	0.6	0.2	0.3	1	0	0.2	0.3	0.1	0	1.3	0	1.4	0.1
IL1B	V												V
GNAS	V						V						V
MAPK8	V			V				V			V
HRH1		V			V
IL1RAP		V										V	V
PRKACB		V		V	V								V
PIK3R2		V
CALM2		V	V		V		V		V		V		V
IL1R1			V
PPP1CB			V
PLCG1				V
PLCB3					V						V		V
MAPK9					V									V
ADCY7						V								V
MAPK14							V
PRKCD								V	V
PPP1CA								V			V
MAPK12											V		V
PIK3CA											V
PTGER2													V
+ 5.8 Development and regeneration	4.4	1.2	0.8	2.6	0.7	1.9	1.7	0.6	0.4	1.3	2	0.8	1.5	2.1
+ 04360: Axon guidance	2.7	1.1	0.1	1.9	0.1	2.6	1.7	0.3	0.4	1.6	2.2	0.8	0.7	1.7
PARD6B	V					V
GNAI2	V			V		V		V
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
SLIT2	V
ROCK1	V					V
ITGB1	V			V		V					V			V
ABL1	V			V		V	V			V		V		V
SRGAP2	V			V				V	V		V
SRGAP3	V			V				V	V		V
NRAS	V					V
WNT5B	V			V		V
GSK3B	V			V
SSH2	V					V				V		V		V
PTPN11	V			V		V			V
PAK4		V					V						V
BUB1B-PAK6		V
PAK6		V
RHOA		V	V				V		V		V			V
FYN		V									V
PLXNA3		V			V			V			V
SEMA3B		V				V				V
PTCH1		V
LIMK1		V
PIK3R2		V
ABLIM1		V	V							V		V	V
EPHB2			V		V					V				V
MET			V			V					V
ABLIM3			V				V					V	V
HRAS				V			V			V		V		V
PLCG1				V
MYL12A				V
SEMA7A					V		V					V	V
L1CAM					V						V
ILK						V
ENAH						V	V			V				V
CXCR4							V			V		V
PPP3CC							V			V				V
PTK2							V			V		V		V
DPYSL2							V			V		V
GNAI3								V			V
ROCK2								V	V		V
CXCL12									V
PAK1											V
PIK3CA											V
RAC1													V
RAC3													V
ARHGEF12													V
SEMA4B													V
SEMA4C													V
EFNB2														V
PDK1														V
+ 04380: Osteoclast differentiation	3.5	0.6	1	1.8	0.9	0.1	0.7	0.6	0.2	0.2	0.6	0.2	1.5	1.3
CSF1	V			V				V		V		V	V
NFKBIA	V
NFKB1	V				V				V
MAPK8	V			V				V			V
STAT1	V			V	V				V
IL1A	V
IL1B	V												V
PPP3CB	V			V		V					V		V
CTSK	V			V
MITF	V
NFATC2	V						V							V
SOCS1	V					V
FHL2	V												V
NFKB2	V			V										V
MAP2K7	V			V		V
MAP3K14		V	V					V
IKBKG		V	V		V		V							V
MAP3K7		V	V											V
FYN		V									V
PIK3R2		V
FOSL1		V	V
CYLD			V		V					V		V
IKBKB			V		V		V						V
IL1R1			V
TRAF2				V
CREB1				V										V
MAPK9					V									V
CHUK							V
MAPK14							V
PPP3CC							V			V				V
GAB2								V
SQSTM1								V	V			V		V
NCF2										V		V
MAPK12											V		V
PIK3CA											V
AKT3													V
IFNGR2													V
PPARG													V
RAC1													V
+ 5.9 Aging	2.2	1.4	0.8	3.6	0.6	2.4	2	0.3	0.2	1.7	0.4	2.2	2.5	2.8
+ 04211: Longevity regulating pathway	1.7	1.5	0.9	3	0.8	1.4	1.3	0.4	0.2	1.3	0.2	1.7	2.3	2.4
NRAS	V					V
PRKAA1	V			V
TP53	V		V									V		V
ADIPOR1	V			V				V
NFKB1	V				V				V
ATG13	V			V
EHMT2	V
PIK3R2		V
PRKACB		V		V	V								V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
TSC2		V			V			V		V
ADIPOR2		V	V				V							V
BAX			V					V		V		V
ATG5			V				V					V	V
RPS6KB1				V		V				V
HRAS				V			V			V		V		V
PRKAG2				V		V
CREB1				V										V
ATF2				V		V	V						V
EIF4E				V		V
ADCY7						V								V
PRKAB2							V					V	V
EHMT1									V		V
MTOR										V
PIK3CA											V
SOD2												V
AKT1S1													V
AKT3													V
TSC1													V
PPARG													V
SIRT1														V
CAMKK2														V
ATG101														V
+ 04213: Longevity regulating pathway - multiple species	1.5	0.6	0.3	2.1	0.1	2	1.5	0	0.1	1.1	0.4	1.5	1.2	1.5
NRAS	V					V
PRKAA1	V			V
HSPA1B	V			V		V	V			V				V
CLPB	V		V			V	V		V		V
HDAC2	V											V
PIK3R2		V
PRKACB		V		V	V								V
HSPA1A		V												V
ATG5			V				V					V	V
RPS6KB1				V		V				V
HRAS				V			V			V		V		V
PRKAG2				V		V
ADCY7						V								V
PRKAB2							V					V	V
MTOR										V
PIK3CA											V
SOD2												V
AKT1S1													V
AKT3													V
SIRT1														V
+ 5.10 Environmental adaptation	0.7	1.9	1.3	2.4	1.9	1	1.5	1.8	1.4	1.6	1.4	1.1	2.3	2.2
+ 04710: Circadian rhythm	0.3	0.3	1.4	1.6	1.6	0.9	1.5	1.6	1	0.9	1	0.9	0.7	2.1
PRKAA1	V			V
FBXL3		V	V			V
CSNK1E			V		V						V		V
FBXW11			V					V						V
PRKAG2				V		V
CREB1				V										V
NR1D1					V					V
PER3					V
CLOCK							V			V		V
BTRC							V
PRKAB2							V					V	V
CSNK1D								V						V
BHLHE40								V	V		V
TPTEP2-CSNK1E									V					V
+ 04713: Circadian entrainment	0.1	0.1	0	0.3	0.7	0.1	0.1	0.1	0	0	0.3	0	0.8	0.5
GNAS	V						V						V
GNAI2	V			V		V		V
CALM2		V	V		V		V		V		V		V
PRKACB		V		V	V								V
CREB1				V										V
PLCB3					V						V		V
PER3					V
ADCY7						V								V
GNAI3								V			V
GNB1													V
RASD1													V
GNG10														V
GNB4														V
+ 04714: Thermogenesis	0.8	2.9	0.7	2.2	1.1	0.6	1.1	1.5	1.4	2	1.1	1	2.5	1.3
GNAS	V						V						V
ARID1B	V									V
NRAS	V					V
MAP3K5	V
PRKAA1	V			V
NDUFC2-KCTD14	V		V			V	V			V
COX20	V							V					V
NDUFV1	V
NDUFA13	V
SDHA	V			V	V					V				V
ATP5ME	V
CREB3		V											V
CREB3L4		V											V
PRKACB		V		V	V								V
KDM3A		V		V			V			V		V		V
SMARCA4		V										V		V
SMARCB1		V	V					V					V
DPF3		V
RPS6KA1		V
TSC2		V			V			V		V
FGFR1		V
ACSL1		V			V		V			V				V
COX15		V
NDUFAB1		V	V		V
NDUFB6		V					V			V				V
NDUFC1		V		V				V	V		V		V
NDUFAF7		V	V		V
SDHC		V			V				V		V
ATP5F1A		V	V					V	V		V			V
ATP5F1D		V
ATP5PB		V	V		V							V
ATP5PF		V	V		V
CPT1C			V					V	V		V
NDUFB3			V
SDHD			V					V						V
ATP5PD			V
CREB1				V										V
ATF2				V		V	V						V
SMARCD1				V	V			V	V
RPS6KB1				V		V				V
HRAS				V			V			V		V		V
MGLL				V		V				V
PRKAG2				V		V
NDUFA12				V		V			V		V		V
COX14				V
ATP5F1C				V
ATP5MF				V								V
SMARCA2					V							V		V
ADCY7						V								V
SMARCD2						V
NDUFB2						V	V			V			V
MAPK14							V
DPF1							V
PRKAB2							V					V	V
COX7A2							V			V	V		V
ARID1A								V	V
ACSL5								V	V
SLC25A29								V			V			V
COA6								V	V		V
NDUFS5								V	V		V			V
PLIN1									V
SOS2									V				V
CPT1A										V		V
MTOR										V
NDUFA11										V		V	V
COA7										V		V
MAPK12											V		V
ATP5MC3											V		V
NDUFAF3												V
NDUFA6												V
PPARG													V
TSC1													V
AKT1S1													V
COX7B2													V
NDUFAF5													V
+ 6. Human Diseases	10.7	4.6	5.9	8.9	5	11.1	6.6	6.4	4.3	7.6	5.9	6.7	6.2	9.5
+ 6.1 Cancer: overview	7.4	3.1	3.9	6.6	4.2	6.8	4	4.3	3.2	4.9	5	3.8	3.7	6.4
+ 05200: Pathways in cancer	4.3	0.5	1.1	3.4	0.5	4.3	2.9	1.4	0.8	2	1.3	1.7	1.6	3.1
WNT5B	V			V		V
ITGB1	V			V		V					V			V
LAMB1	V			V			V					V
FZD6	V			V		V		V			V		V
ABL1	V			V		V	V			V		V		V
CRK	V		V		V		V			V				V
STAT5A	V			V										V
EGFR	V					V		V	V		V
TPM3	V			V	V			V	V		V			V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
GSK3B	V			V
STAT1	V			V	V				V
NRAS	V					V
NFKBIA	V
NFKB1	V				V				V
NFKB2	V			V										V
MAPK8	V			V				V			V
TP53	V		V									V		V
HIF1A	V					V			V		V
CREBBP	V					V		V			V		V
MLH1	V												V
MSH6	V		V							V
HDAC2	V											V
MITF	V
MAX	V			V				V	V			V		V
CCND3	V			V		V	V			V	V			V
CDK2	V							V		V
BIRC2	V
TRAF1	V		V		V
TRAF3	V			V		V
DAPK3	V			V			V			V
ETS1	V			V		V			V		V
CXCL8	V
CSF2RA	V		V				V			V	V			V
IL6	V					V								V
GNAS	V						V						V
ROCK1	V					V
GNAI2	V			V		V		V
NFE2L2	V			V		V				V
GSTM1	V			V								V
GSTO1	V			V		V								V
LRP5	V					V
BBC3	V						V		V
CASP7	V			V		V						V	V
WNT9A		V
CTNNA1		V	V
LAMA3		V
LAMA4		V
LAMC2		V				V		V						V
ITGA6		V	V		V							V		V
PIK3R2		V
ERBB2		V					V			V		V		V
FGFR1		V
APC		V					V			V		V
IKBKG		V	V		V		V							V
RALGDS		V	V
RHOA		V	V				V		V		V			V
PTCH1		V
RUNX1		V	V				V
PML		V	V		V			V				V	V
VEGFA		V			V
LPAR2		V
PRKACB		V		V	V								V
GNA11		V
MGST2		V	V		V					V		V
DDB2		V			V						V
CALM2		V	V		V		V		V		V		V
BCL2L11		V		V	V
CASP3			V					V			V
MET			V			V					V
IKBKB			V		V		V						V
CUL2			V
BAX			V					V		V		V
RXRB			V					V
CASP8			V					V	V			V	V
BIRC3			V
PPARD			V			V		V	V		V
F2R			V
NQO1			V										V
GSTM4			V										V
TXNRD2			V				V			V		V	V
ITGAV				V		V		V		V
BCL2L1				V		V								V
HRAS				V			V			V		V		V
PLCG1				V
ARNT				V
CDK6				V		V	V					V	V
TRAF2				V
ARHGEF1				V
GSTT2B				V		V	V			V		V
TXNRD1				V		V	V
POLK				V		V		V					V
RPS6KB1				V		V				V
MAPK9					V									V
RAD51					V		V			V
PLCB3					V						V		V
NCOA1					V				V
LAMB2						V								V
LAMC1						V								V
ITGA2						V						V
STAT5B						V
TGFA						V	V						V
PDGFA						V
ARAF						V
VHL						V	V					V	V
MECOM						V	V			V		V	V
CTBP2						V				V		V		V
SKP2						V		V			V			V
XIAP						V						V
TRAF5						V
ADCY7						V								V
IL23A						V
COL4A5							V		V					V
PTK2							V			V		V		V
CHUK							V
RASSF5							V						V
ELOB							V			V		V
CTBP1							V
PAX8							V			V		V
JUP							V			V		V		V
LPAR1							V			V
CXCR4							V			V		V
APAF1							V			V		V
WNT3								V
TFG								V						V
SMAD2								V		V	V
BIRC5								V	V		V
ROCK2								V	V		V
GNAI3								V			V
IL7R								V						V
BCR									V
SOS2									V				V
CXCL12									V
NCOA3									V				V
MTOR										V
E2F3										V
ARHGEF11										V
PIK3CA											V
CCNE1											V
RAC1													V
RAC3													V
PPARG													V
CCNA1													V
PTGS2													V
AKT3													V
PTGER2													V
GNB1													V
ARHGEF12													V
MGST1													V
ELK1													V
IFNGR2													V
IL6ST													V
TCF7L1														V
ZBTB17														V
CDKN1A														V
BMP4														V
GNG10														V
GNB4														V
+ 05202: Transcriptional misregulation in cancer	2.1	0.8	1.3	1.5	1.6	1.4	0.4	0.7	0.4	1	0.3	2.1	0.3	2.4
EWSR1	V			V		V		V	V		V			V
FUS	V			V		V
IL6	V					V								V
NFKBIZ	V
CXCL8	V
TRAF1	V		V		V
MAX	V			V				V	V			V		V
TP53	V		V									V		V
CSF2	V											V
H3F3A	V			V		V			V		V
TAF15	V			V		V					V
HDAC2	V											V
NFKB1	V				V				V
MITF	V
ETV1		V	V		V
ETV4		V
PLAU		V
RUNX1		V	V				V
PML		V	V		V			V				V	V
RUNX2		V							V					V
KDM6A		V	V
MLLT1		V
BCL6		V		V						V
DDB2		V			V						V
ASPSCR1			V				V			V		V		V
MET			V			V					V
RXRB			V					V
BIRC3			V
BAX			V					V		V		V
BCL2L1				V		V								V
SIN3A				V						V		V		V
HMGA2				V								V	V
NSD2				V				V	V		V
POLK				V		V		V					V
HIST2H3A					V
HIST2H3D					V
HIST1H3C					V
HIST1H3J					V
HIST1H3H					V
HIST1H3B					V
PDGFA						V
ZEB1						V	V			V		V		V
NCOR1						V
FLI1							V
PAX8							V			V		V
JUP							V			V		V		V
PTK2							V			V		V		V
CCNT2								V
ATM										V		V		V
BMP2K										V
SSX1													V
PPARG													V
MMP3													V
CCNA1													V
FUT8													V
CDKN1A														V
TCF3														V
ZBTB17														V
+ 05206: MicroRNAs in cancer	3.3	1.6	2.7	2.7	1.9	2.8	3.4	1.2	0.4	3	2.4	2.1	1.6	2.5
CDC25B	V							V		V				V
BCL2L2	V		V		V
CRK	V		V		V		V			V				V
CREBBP	V					V		V			V		V
TPM1	V			V			V
EGFR	V					V		V	V		V
ABL1	V			V		V	V			V		V		V
NRAS	V					V
ROCK1	V					V
VIM	V			V							V
SOCS1	V					V
RDX	V			V				V			V		V
ABCC1	V			V		V			V				V
NFKB1	V				V				V
TP53	V		V									V		V
SHC1	V			V									V
VEGFA		V			V
DNMT3A		V	V
MCL1		V	V		V		V			V		V
PAK4		V					V						V
ERBB2		V					V			V		V		V
APC		V					V			V		V
PIK3R2		V
BCL2L11		V		V	V
CDCA5		V	V				V			V
RHOA		V	V				V		V		V			V
PLAU		V
CDC25A			V				V			V
STMN1			V				V			V
MET			V			V					V
CASP3			V					V			V
BRCA1			V		V			V			V
IKBKB			V		V		V						V
BMF			V		V
CDK6				V		V	V					V	V
HMGA2				V								V	V
CCNG1				V		V					V
HRAS				V			V			V		V		V
CD44				V	V						V		V
PLCG1				V
ZEB1						V	V			V		V		V
FOXP1						V
DICER1						V							V
PDGFA						V
SLC7A1							V			V		V
PDCD4								V
WNT3								V
SOS2									V				V
MTOR										V
E2F3										V
ATM										V		V		V
CCNE1											V
PIK3CA											V
FSCN1												V
PTGS2													V
CYP1B1														V
SIRT1														V
CDKN1A														V
THBS1														V
+ 05205: Proteoglycans in cancer	1.9	1.4	0.1	3.2	0.5	3.1	0.2	1.9	1	0.9	3.1	0.7	1.3	1.7
ROCK1	V					V
FLNB	V			V		V				V
NRAS	V					V
CTTN	V			V		V						V
TP53	V		V									V		V
HIF1A	V					V			V		V
EIF4B	V											V		V
HPSE	V			V	V								V
ITGB1	V			V		V					V			V
FZD6	V			V		V		V			V		V
RDX	V			V				V			V		V
PTPN11	V			V		V			V
EGFR	V					V		V	V		V
WNT5B	V			V		V
ERBB2		V					V			V		V		V
RHOA		V	V				V		V		V			V
PIK3R2		V
FLNC		V												V
PLAU		V
VEGFA		V			V
FGFR1		V
PTCH1		V
HSPG2		V				V		V		V		V
PRKACB		V		V	V								V
GPC1		V
WNT9A		V
CD63		V		V	V				V			V	V
PPP1CB			V
MET			V			V					V
PDPK1			V		V			V						V
CASP3			V					V			V
CD44				V	V						V		V
PPP1R12A				V		V
HRAS				V			V			V		V		V
ARHGEF1				V
PXN				V									V
RPS6KB1				V		V				V
ITGAV				V		V		V		V
PLCG1				V
CAV1					V						V
ARAF						V
ITGA2						V						V
CAV2						V	V		V		V		V
PTK2							V			V		V		V
MAPK14							V
ROCK2								V	V		V
PPP1CA								V			V
SMAD2								V		V	V
PDCD4								V
PTPN6								V	V					V
WNT3								V
SOS2									V				V
DROSHA										V
MTOR										V
PIK3CA											V
PAK1											V
MAPK12											V		V
AKT3													V
ARHGEF12													V
RAC1													V
ELK1													V
THBS1														V
CDKN1A														V
SDC2														V
+ 05204: Chemical carcinogenesis	0.2	0.9	0.4	0.8	0.5	0.2	0.2	0.8	0.1	0.7	0.2	1.1	0.2	0.7
GSTM1	V			V								V
GSTO1	V			V		V								V
ALDH3B1		V	V
MGST2		V	V		V					V		V
EPHX1		V							V		V
CBR1		V			V			V		V
KYAT3		V			V		V			V		V
GSTM4			V										V
GSTT2B				V		V	V			V		V
ARNT				V
CYP1A1								V			V
ADH4								V
ADH7								V
KYAT1												V
MGST1													V
PTGS2													V
CYP2E1														V
CYP1B1														V
NAT1														V
+ 05203: Viral carcinogenesis	4.2	2.4	2.4	5.5	5.7	3.6	1.7	3.5	1.8	3.2	3.6	2.4	2.5	4
TP53	V		V									V		V
CHD4	V			V		V		V
TRAF1	V		V		V
TRAF3	V			V		V
STAT5A	V			V										V
NFKB1	V				V				V
NFKB2	V			V										V
CDK2	V							V		V
CCND3	V			V		V	V			V	V			V
MRPS18B	V			V		V
NRAS	V					V
GTF2H2	V			V		V
GTF2H4	V			V			V			V		V		V
GTF2H2C	V		V			V		V		V	V		V
GTF2H2C_2	V					V		V		V	V			V
CREBBP	V					V		V			V		V
HDAC2	V											V
NFKBIA	V
C3	V
HLA-E	V			V		V		V	V		V		V
DDX3X	V			V		V								V
EIF2AK2	V		V						V		V			V
CDK1	V		V							V				V
IKBKG		V	V		V		V							V
CREB3		V											V
ATF6B		V	V		V		V			V		V		V
CREB3L4		V											V
PIK3R2		V
MAD1L1		V	V				V			V		V
YWHAE		V						V	V		V			V
GTF2H1		V			V					V
HDAC7		V			V						V		V
HDAC9		V		V	V			V			V		V
RHOA		V	V				V		V		V			V
GSN		V					V			V				V
CHEK1		V								V		V
IRF7		V		V			V
HLA-B		V				V				V		V		V
HLA-C		V	V		V		V			V			V
PRKACB		V		V	V								V
UBE3A			V
CASP3			V					V			V
CASP8			V					V	V			V	V
BAX			V					V		V		V
PKM			V		V			V	V				V
SP100			V		V			V		V		V	V
PXN				V									V
PSMC1				V
TRAF2				V
CREB1				V										V
ATF2				V		V	V						V
CDK6				V		V	V					V	V
RANBP1				V		V		V
HRAS				V			V			V		V		V
YWHAZ				V				V	V		V			V
DNAJA3				V						V		V
HDAC8				V		V					V
LTBR				V					V				V
HIST1H2BK				V	V
HIST1H2BJ				V	V
GTF2H3					V			V	V		V
HLA-A					V				V		V
HIST1H2BD					V
HIST1H2BC					V
HIST1H2BB					V
HIST2H2BF					V
HIST1H2BN					V
HIST1H2BM					V
HIST1H2BO					V
HIST2H4B					V
HIST1H4K					V
HIST1H4J					V
HIST1H4C					V
HIST1H4B					V
TRAF5						V
STAT5B						V
SKP2						V		V			V			V
GTF2A2						V
VDAC3							V			V		V
RBPJ								V			V
GTF2A1								V	V			V		V
SCRIB										V		V
PIK3CA											V
CCNE1											V
CCNA1													V
RAC1													V
IL6ST													V
CDKN1A														V
HDAC6														V
+ 05230: Central carbon metabolism in cancer	1.7	0.5	1.7	0.3	0.1	1.8	0.9	0.6	0.7	1.3	1.5	0.5	0.4	1.3
HIF1A	V					V			V		V
LDHA	V						V			V
EGFR	V					V		V	V		V
NRAS	V					V
TP53	V		V									V		V
PFKM	V		V			V	V				V			V
ERBB2		V					V			V		V		V
FGFR1		V
PIK3R2		V
PKM			V		V			V	V				V
MET			V			V					V
SCO2			V
IDH1			V
GCK				V		V
HRAS				V			V			V		V		V
G6PD								V					V
SIRT3										V
MTOR										V
PIK3CA											V
AKT3													V
PDK1														V
+ 05231: Choline metabolism in cancer	0.8	1	1.1	0.9	1.3	1.2	0.3	1.6	1.7	1.1	1.3	0.5	2.1	0.8
MAPK8	V			V				V			V
NRAS	V					V
EGFR	V					V		V	V		V
PIP5K1A	V		V					V	V		V			V
HIF1A	V					V			V		V
PIK3R2		V
SLC44A2		V	V		V		V			V			V
RALGDS		V	V
TSC2		V			V			V		V
DGKA		V		V		V
DGKZ		V	V		V				V			V
PDPK1			V		V			V						V
LYPLA1			V		V		V					V	V
HRAS				V			V			V		V		V
PLCG1				V
RPS6KB1				V		V				V
MAPK9					V									V
PDGFA						V
SLC44A1								V	V		V
PLPP1								V	V				V
SOS2									V				V
MTOR										V
DGKD										V		V
PIK3CA											V
AKT3													V
PDGFD													V
CHPT1													V
TSC1													V
RAC1													V
RAC3													V
SLC22A5														V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	3.8	0.2	0.9	1.4	0.7	2.1	2.1	1.1	2.7	1.3	1.1	0.3	1.3	2.8
NFKBIA	V
NFKB1	V				V				V
NRAS	V					V
NFATC2	V						V							V
NFATC3	V					V				V
PPP3CB	V			V		V					V		V
PTPN11	V			V		V			V
EGFR	V					V		V	V		V
STAT1	V			V	V				V
CSNK2A1	V							V	V					V
CSNK2A2	V							V	V					V
MYD88	V					V			V					V
HIF1A	V					V			V		V
IKBKG		V	V		V		V							V
PIK3R2		V
TMED7-TICAM2		V	V									V		V
IKBKB			V		V		V						V
MAP3K3			V					V						V
CSNK2B			V				V			V		V	V
HRAS				V			V			V		V		V
PLCG1				V
RPS6KB1				V		V				V
CHUK							V
PPP3CC							V			V				V
MAPK14							V
PTPN6								V	V					V
MTOR										V
PIK3CA											V
MAPK12											V		V
AKT3													V
IFNGR2													V
CSNK2A3													V
+ 6.2 Cancer: specific types	6.7	3.4	3.7	6	2.7	8.4	5	4.5	2.1	5.2	3.8	4.8	4.5	6.8
+ 05210: Colorectal cancer	2.1	1.2	1.3	1.5	0.5	1.4	1	1.9	1.2	1.7	2.3	0.6	1.4	1.4
MLH1	V												V
MAPK8	V			V				V			V
TP53	V		V									V		V
GSK3B	V			V
MSH6	V		V							V
BBC3	V						V		V
NRAS	V					V
EGFR	V					V		V	V		V
PIK3R2		V
APC		V					V			V		V
RALGDS		V	V
RHOA		V	V				V		V		V			V
DDB2		V			V						V
BCL2L11		V		V	V
CASP3			V					V			V
BAX			V					V		V		V
POLK				V		V		V					V
HRAS				V			V			V		V		V
RPS6KB1				V		V				V
MAPK9					V									V
ARAF						V
TGFA						V	V						V
SMAD2								V		V	V
BIRC5								V	V		V
SOS2									V				V
MTOR										V
PIK3CA											V
RAC1													V
RAC3													V
AKT3													V
TCF7L1														V
CDKN1A														V
+ 05212: Pancreatic cancer	1.2	1.4	1.2	1.7	2.7	2.1	2	1.3	0.6	2	1.4	0.8	1.6	1.6
NFKB1	V				V				V
MAPK8	V			V				V			V
STAT1	V			V	V				V
EGFR	V					V		V	V		V
TP53	V		V									V		V
ERBB2		V					V			V		V		V
PIK3R2		V
IKBKG		V	V		V		V							V
RALGDS		V	V
VEGFA		V			V
DDB2		V			V						V
IKBKB			V		V		V						V
BAX			V					V		V		V
BCL2L1				V		V								V
CDK6				V		V	V					V	V
RPS6KB1				V		V				V
POLK				V		V		V					V
MAPK9					V									V
RAD51					V		V			V
ARAF						V
TGFA						V	V						V
CHUK							V
SMAD2								V		V	V
E2F3										V
MTOR										V
PIK3CA											V
AKT3													V
RAC1													V
RAC3													V
CDKN1A														V
+ 05225: Hepatocellular carcinoma	1.9	0.8	1	3.5	0.3	3.7	1.1	1.2	0.2	2.1	0.7	1.9	2.1	0.8
EGFR	V					V		V	V		V
NRAS	V					V
SHC1	V			V									V
GSK3B	V			V
LRP5	V					V
FZD6	V			V		V		V			V		V
WNT5B	V			V		V
TP53	V		V									V		V
ARID1B	V									V
NFE2L2	V			V		V				V
GSTM1	V			V								V
GSTO1	V			V		V								V
PIK3R2		V
APC		V					V			V		V
WNT9A		V
DDB2		V			V						V
SMARCB1		V	V					V					V
SMARCA4		V										V		V
MGST2		V	V		V					V		V
PHF10		V	V		V					V			V
DPF3		V
BAX			V					V		V		V
MET			V			V					V
NQO1			V										V
GSTM4			V										V
TXNRD2			V				V			V		V	V
HRAS				V			V			V		V		V
RPS6KB1				V		V				V
POLK				V		V		V					V
PLCG1				V
GSTT2B				V		V	V			V		V
TXNRD1				V		V	V
BCL2L1				V		V								V
CDK6				V		V	V					V	V
SMARCD1				V	V			V	V
BRD7				V		V	V					V	V
SMARCA2					V							V		V
ARAF						V
TGFA						V	V						V
SMARCD2						V
DPF1							V
WNT3								V
SMAD2								V		V	V
ARID1A								V	V
SOS2									V				V
MTOR										V
E2F3										V
PIK3CA											V
PBRM1											V
AKT3													V
ELK1													V
MGST1													V
TCF7L1														V
CDKN1A														V
+ 05226: Gastric cancer	1.6	0.4	0.3	0.9	0	1.4	0.2	1.2	0	1.6	0.9	0.5	0.2	0.5
NRAS	V					V
SHC1	V			V									V
GSK3B	V			V
LRP5	V					V
FZD6	V			V		V		V			V		V
WNT5B	V			V		V
TP53	V		V									V		V
CDK2	V							V		V
MLH1	V												V
EGFR	V					V		V	V		V
PIK3R2		V
APC		V					V			V		V
WNT9A		V
DDB2		V			V						V
ERBB2		V					V			V		V		V
CTNNA1		V	V
BAX			V					V		V		V
MET			V			V					V
RXRB			V					V
HRAS				V			V			V		V		V
RPS6KB1				V		V				V
POLK				V		V		V					V
ARAF						V
JUP							V			V		V		V
WNT3								V
SMAD2								V		V	V
SOS2									V				V
MTOR										V
E2F3										V
PIK3CA											V
CCNE1											V
AKT3													V
TCF7L1														V
CDKN1A														V
+ 05214: Glioma	0.8	0.4	0.4	1.7	0.3	2.5	0.8	0.6	1	0.8	1	0.8	1.6	0.5
EGFR	V					V		V	V		V
SHC1	V			V									V
TP53	V		V									V		V
NRAS	V					V
CALM2		V	V		V		V		V		V		V
PIK3R2		V
DDB2		V			V						V
BAX			V					V		V		V
CAMK1				V		V			V
CDK6				V		V	V					V	V
PLCG1				V
HRAS				V			V			V		V		V
POLK				V		V		V					V
TGFA						V	V						V
PDGFA						V
ARAF						V
SOS2									V				V
MTOR										V
E2F3										V
PIK3CA											V
AKT3													V
CDKN1A														V
+ 05216: Thyroid cancer	1.2	0.2	1.2	1.3	0.8	0.7	0.7	2.4	0.3	1.2	0.8	1.8	0.5	2.8
NRAS	V					V
TPM3	V			V	V			V	V		V			V
TP53	V		V									V		V
DDB2		V			V						V
RXRB			V					V
BAX			V					V		V		V
HRAS				V			V			V		V		V
POLK				V		V		V					V
PAX8							V			V		V
TFG								V						V
PPARG													V
TCF7L1														V
CDKN1A														V
+ 05221: Acute myeloid leukemia	1	0.9	1.4	0.7	1.2	1.5	1.9	0.3	0.7	1	0.3	1	1.1	1.4
NRAS	V					V
NFKB1	V				V				V
STAT5A	V			V										V
CSF2	V											V
RUNX1		V	V				V
PML		V	V		V			V				V	V
IKBKG		V	V		V		V							V
PIK3R2		V
PPARD			V			V		V	V		V
IKBKB			V		V		V						V
HRAS				V			V			V		V		V
RPS6KB1				V		V				V
STAT5B						V
ARAF						V
JUP							V			V		V		V
CHUK							V
SOS2									V				V
MTOR										V
PIK3CA											V
CCNA1													V
AKT3													V
TCF7L1														V
+ 05220: Chronic myeloid leukemia	3.1	0.7	1.5	2.5	1.4	3.2	3.2	0.5	1	2	0.3	2.4	1.6	2.8
PTPN11	V			V		V			V
ABL1	V			V		V	V			V		V		V
TP53	V		V									V		V
HDAC2	V											V
STAT5A	V			V										V
NFKB1	V				V				V
NFKBIA	V
SHC1	V			V									V
CRK	V		V		V		V			V				V
NRAS	V					V
RUNX1		V	V				V
IKBKG		V	V		V		V							V
PIK3R2		V
DDB2		V			V						V
IKBKB			V		V		V						V
BAX			V					V		V		V
BCL2L1				V		V								V
CDK6				V		V	V					V	V
HRAS				V			V			V		V		V
POLK				V		V		V					V
MECOM						V	V			V		V	V
CTBP2						V				V		V		V
STAT5B						V
ARAF						V
CTBP1							V
CHUK							V
GAB2								V
BCR									V
SOS2									V				V
E2F3										V
PIK3CA											V
AKT3													V
CDKN1A														V
+ 05217: Basal cell carcinoma	1	0.9	0.3	1.2	0.1	0.7	0.1	1.2	0	0.3	0.4	0.6	0.2	1
WNT5B	V			V		V
FZD6	V			V		V		V			V		V
GSK3B	V			V
TP53	V		V									V		V
PTCH1		V
WNT9A		V
APC		V					V			V		V
DDB2		V			V						V
BAX			V					V		V		V
POLK				V		V		V					V
WNT3								V
BMP4														V
TCF7L1														V
CDKN1A														V
+ 05218: Melanoma	0.9	0.4	0.5	0.6	0.1	2.1	0.2	0.6	0.1	0.5	1	0.9	0.6	0.5
NRAS	V					V
MITF	V
EGFR	V					V		V	V		V
TP53	V		V									V		V
FGFR1		V
PIK3R2		V
DDB2		V			V						V
MET			V			V					V
BAX			V					V		V		V
CDK6				V		V	V					V	V
HRAS				V			V			V		V		V
POLK				V		V		V					V
PDGFA						V
ARAF						V
E2F3										V
PIK3CA											V
PDGFD													V
AKT3													V
CDKN1A														V
+ 05211: Renal cell carcinoma	1.7	1.2	0.5	1	0.7	3	2.2	0.1	1.1	0.9	1.9	0.5	2.2	0.5
PTPN11	V			V		V			V
CREBBP	V					V		V			V		V
HIF1A	V					V			V		V
CRK	V		V		V		V			V				V
ETS1	V			V		V			V		V
NRAS	V					V
VEGFA		V			V
PAK4		V					V						V
BUB1B-PAK6		V
PAK6		V
PIK3R2		V
CUL2			V
MET			V			V					V
ARNT				V
HRAS				V			V			V		V		V
RAP1A					V		V			V			V
VHL						V	V					V	V
TGFA						V	V						V
ARAF						V
ELOB							V			V		V
SOS2									V				V
PAK1											V
PIK3CA											V
RAC1													V
AKT3													V
CDKN1A														V
+ 05219: Bladder cancer	2.1	0.5	0.6	0.7	0.3	1.1	1.1	0.2	0.3	1.6	0.2	1.1	0	2.1
CXCL8	V
EGFR	V					V		V	V		V
DAPK3	V			V			V			V
TP53	V		V									V		V
NRAS	V					V
VEGFA		V			V
ERBB2		V					V			V		V		V
TYMP			V
HRAS				V			V			V		V		V
ARAF						V
E2F3										V
THBS1														V
CDKN1A														V
+ 05215: Prostate cancer	2.6	1.3	0.5	0.9	0.7	1.9	1.9	0.9	0.7	1.5	1	0.8	1.8	2.9
NFKB1	V				V				V
NFKBIA	V
CREBBP	V					V		V			V		V
CDK2	V							V		V
NRAS	V					V
TP53	V		V									V		V
EGFR	V					V		V	V		V
GSK3B	V			V
HSP90AA1	V			V				V	V		V			V
HSP90AB1	V			V		V	V			V		V		V
ERBB2		V					V			V		V		V
FGFR1		V
IKBKG		V	V		V		V							V
CREB3		V											V
CREB3L4		V											V
PIK3R2		V
PLAU		V
IKBKB			V		V		V						V
PDPK1			V		V			V						V
HRAS				V			V			V		V		V
CREB1				V										V
PDGFA						V
TGFA						V	V						V
ARAF						V
ZEB1						V	V			V		V		V
CHUK							V
SOS2									V				V
E2F3										V
MTOR										V
CCNE1											V
PIK3CA											V
PDGFD													V
AKT3													V
MMP3													V
TCF7L1														V
CDKN1A														V
+ 05213: Endometrial cancer	1.6	1.5	1.1	0.8	0.4	1.7	0.7	1.3	0.5	1.1	0.8	1.6	1.3	2.1
NRAS	V					V
GSK3B	V			V
MLH1	V												V
EGFR	V					V		V	V		V
TP53	V		V									V		V
APC		V					V			V		V
CTNNA1		V	V
ERBB2		V					V			V		V		V
PIK3R2		V
DDB2		V			V						V
PDPK1			V		V			V						V
BAX			V					V		V		V
HRAS				V			V			V		V		V
POLK				V		V		V					V
ILK						V
ARAF						V
SOS2									V				V
PIK3CA											V
ELK1													V
AKT3													V
TCF7L1														V
CDKN1A														V
+ 05224: Breast cancer	1.3	0.4	0	1.5	0.1	1.4	0.2	0.6	0.2	0.7	0.4	0.5	0.4	0.5
EGFR	V					V		V	V		V
NRAS	V					V
SHC1	V			V									V
GSK3B	V			V
LRP5	V					V
FZD6	V			V		V		V			V		V
WNT5B	V			V		V
NFKB2	V			V										V
TP53	V		V									V		V
ERBB2		V					V			V		V		V
PIK3R2		V
APC		V					V			V		V
WNT9A		V
FGFR1		V
DDB2		V			V						V
BRCA1			V		V			V			V
BAX			V					V		V		V
HRAS				V			V			V		V		V
RPS6KB1				V		V				V
CDK6				V		V	V					V	V
POLK				V		V		V					V
NCOA1					V				V
ARAF						V
WNT3								V
NCOA3									V				V
SOS2									V				V
MTOR										V
E2F3										V
PIK3CA											V
AKT3													V
TCF7L1														V
CDKN1A														V
+ 05222: Small cell lung cancer	2.7	1.4	2.3	2.5	1.5	3.8	2	2.5	0.4	1.2	1.4	2.7	0.6	4.4
CDK2	V							V		V
ITGB1	V			V		V					V			V
MAX	V			V				V	V			V		V
LAMB1	V			V			V					V
BIRC2	V
NFKBIA	V
TRAF1	V		V		V
TRAF3	V			V		V
NFKB1	V				V				V
TP53	V		V									V		V
ITGA6		V	V		V							V		V
PIK3R2		V
LAMA3		V
LAMA4		V
LAMC2		V				V		V						V
IKBKG		V	V		V		V							V
DDB2		V			V						V
RXRB			V					V
BIRC3			V
IKBKB			V		V		V						V
BAX			V					V		V		V
CASP3			V					V			V
ITGAV				V		V		V		V
BCL2L1				V		V								V
TRAF2				V
CDK6				V		V	V					V	V
POLK				V		V		V					V
ITGA2						V						V
LAMB2						V								V
LAMC1						V								V
XIAP						V						V
TRAF5						V
SKP2						V		V			V			V
APAF1							V			V		V
PTK2							V			V		V		V
COL4A5							V		V					V
CHUK							V
E2F3										V
CCNE1											V
PIK3CA											V
AKT3													V
PTGS2													V
ZBTB17														V
FHIT														V
CDKN1A														V
+ 05223: Non-small cell lung cancer	1	0.5	1	1.5	0.3	2.3	1.4	1.5	0.4	1	0.7	1.4	1.5	2.3
NRAS	V					V
EGFR	V					V		V	V		V
STAT5A	V			V										V
TP53	V		V									V		V
PIK3R2		V
ERBB2		V					V			V		V		V
DDB2		V			V						V
PDPK1			V		V			V						V
RXRB			V					V
BAX			V					V		V		V
CDK6				V		V	V					V	V
HRAS				V			V			V		V		V
PLCG1				V
POLK				V		V		V					V
TGFA						V	V						V
ARAF						V
STAT5B						V
RASSF5							V						V
SOS2									V				V
E2F3										V
PIK3CA											V
AKT3													V
FHIT														V
CDKN1A														V
+ 6.12 Drug resistance: antineoplastic	4.5	1.4	2.7	2.8	1.8	4.1	2.5	2.2	2.2	3	1.5	3	2.5	3.2
+ 01521: EGFR tyrosine kinase inhibitor resistance	1.5	0.6	0.4	2.9	0.5	3.5	0.8	0.2	0.2	1.1	0.5	0.7	0.8	0.8
EGFR	V					V		V	V		V
GSK3B	V			V
SHC1	V			V									V
NRAS	V					V
NF1	V			V		V	V					V
IL6	V					V								V
ERBB2		V					V			V		V		V
PIK3R2		V
BCL2L11		V		V	V
VEGFA		V			V
MET			V			V					V
BAX			V					V		V		V
NRG1			V
RPS6KB1				V		V				V
PLCG1				V
HRAS				V			V			V		V		V
BCL2L1				V		V								V
EIF4E				V		V
AXL					V
TGFA						V	V						V
ARAF						V
PDGFA						V
SOS2									V				V
MTOR										V
PIK3CA											V
AKT3													V
PDGFD													V
+ 01524: Platinum drug resistance	3.2	0.7	3.6	1	0.6	0.9	1.3	2.2	1.5	2.4	1.4	3.6	1.3	2.1
TP53	V		V									V		V
BIRC2	V
BBC3	V						V		V
GSTM1	V			V								V
GSTO1	V			V		V								V
MLH1	V												V
XPA	V						V
MSH6	V		V							V
REV3L	V								V				V
MAP3K5	V
MGST2		V	V		V					V		V
ERCC1		V							V
ERBB2		V					V			V		V		V
PIK3R2		V
CASP3			V					V			V
BIRC3			V
CASP8			V					V	V			V	V
BAX			V					V		V		V
GSTM4			V										V
BRCA1			V		V			V			V
PDPK1			V		V			V						V
POLH			V
BCL2L1				V		V								V
GSTT2B				V		V	V			V		V
XIAP						V						V
APAF1							V			V		V
BIRC5								V	V		V
ATP7A								V			V
ATM										V		V		V
TOP2B										V		V
PIK3CA											V
MGST1													V
AKT3													V
CDKN1A														V
+ 01523: Antifolate resistance	3.1	1.4	1.4	1	2.2	2.7	2.1	1.6	2.2	0.9	0.4	0.9	1.8	2.1
ABCC1	V			V		V			V				V
DHFR	V					V	V			V		V		V
NFKB1	V				V				V
IL6	V					V								V
IL1B	V												V
SHMT1	V					V				V		V	V
ABCC4		V						V
GART		V	V		V			V	V					V
IKBKG		V	V		V		V							V
IKBKB			V		V		V						V
ATIC				V		V
CHUK							V
ABCC3								V	V		V
+ 01522: Endocrine resistance	1.1	0.2	0.1	0.9	0.1	1.2	0.8	0.3	0.4	1.5	0.6	0.8	1.1	1.5
EGFR	V					V		V	V		V
NRAS	V					V
SHC1	V			V									V
GNAS	V						V						V
MAPK8	V			V				V			V
TP53	V		V									V		V
PRKACB		V		V	V								V
PIK3R2		V
ERBB2		V					V			V		V		V
BAX			V					V		V		V
HRAS				V			V			V		V		V
RPS6KB1				V		V				V
MAPK9					V									V
ARAF						V
ADCY7						V								V
NCOR1						V
MAPK14							V
PTK2							V			V		V		V
NCOA3									V				V
SOS2									V				V
E2F3										V
MTOR										V
PIK3CA											V
MAPK12											V		V
AKT3													V
CDKN1A														V

**Save / Export**
META-Z-score:	download
Z-score:	download
Genes in pathway/subsystem/system:	download