Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	Primary_vs_231_UP	Primary_vs_231_DOWN	1Lung_vs_231_UP	1Lung_vs_231_DOWN	2Lung_vs_231_UP	2Lung_vs_231_DOWN	1Lung_vs_Primary_UP	1Lung_vs_Primary_DOWN	2Lung_vs_Primary_UP	2Lung_vs_Primary_DOWN	2Lung_vs_1Lung_UP	2Lung_vs_1Lung_DOWN
	235/583	212/526	373/864	290/762	494/1258	759/1935	372/856	281/697	550/1417	807/2024	261/631	517/1321
+ 1. Metabolism	2.9	5.6	5.3	3.6	4.9	4.4	5.7	3.7	5.3	3.4	5.1	3.8
+ 1.0 Global and overview maps	0	2.4	0.5	1.1	0.9	0.8	1.1	0.7	2.2	0.3	1.3	0.3
+ 01100: Metabolic pathways	0	1.8	0.9	0	0.7	0	1.5	0	1.5	0	1.4	0
NOS1	V							V		V
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
PDE10A	V			V		V		V		V
GUCY1A1	V										V
GCLM	V					V				V		V
CYP1A1	V		V		V				V
ALPL	V				V						V
CYP24A1	V		V		V
HSD11B1	V							V		V
HSD3B1	V		V		V			V		V
HSD3B2	V		V		V
IL4I1	V									V
KL	V							V
AKR1C3	V			V		V		V		V		V
CYP27B1	V		V		V
CMPK2	V									V		V
PLA2G4A	V		V		V		V		V
NMNAT1	V
PTDSS1	V		V		V					V		V
LIPG	V		V		V
ST6GALNAC5	V		V		V				V		V
SPHK1	V		V		V				V		V
QRSL1	V
COQ3	V
RDH16	V
COX7B2	V		V		V		V		V		V
ARG2		V					V		V
HADH		V
CYP1A2		V		V		V
UGT8		V
SCD		V		V		V
SCD5		V					V		V
ALDOC		V		V					V		V
GGT7		V	V				V		V			V
ALDH3B1		V
ALDH7A1		V				V	V
PI4K2B		V				V						V
PIK3C2A		V		V		V		V		V
GLYAT		V							V	V
UPP1		V				V
PDE3B		V					V		V
PDE4D		V					V
PDE9A		V					V					V
ACSS1		V		V		V
HEXD		V							V
B4GALNT4		V
CHST9		V		V		V			V		V
IDUA		V
ALPP		V		V		V
ALDH5A1		V					V		V			V
TYR		V					V		V
HAAO		V				V
ASRGL1		V	V		V		V		V
MTAP		V							V
TM7SF2		V					V		V
CYP11B2		V		V					V		V
PLAAT3		V					V
PLA2G5		V				V
PLA2G7		V
CERS6		V					V		V
ALOX5		V		V		V				V		V
PTGES		V
NMNAT3		V				V				V		V
NNMT		V		V		V
ST6GAL2		V							V
B4GALT6		V					V		V
NDST4		V
HPSE		V				V	V
NAGLU		V
IDH2		V				V
DHRS3		V				V	V					V
ACSS3		V			V		V		V
GPLD1		V				V	V			V		V
GYG2		V		V		V				V		V
MGST2			V				V		V
G6PC3			V			V	V			V		V
PIK3CG			V		V		V		V
FIG4			V		V
PLCB1			V				V					V
PLCG2			V
MAOA			V		V		V		V
MAOB			V			V				V		V
KYNU			V		V		V		V
UGT2B11			V		V
UGT2B28			V		V				V		V
NT5C			V				V		V
ENTPD3			V
ENPP4			V		V		V		V			V
PDE11A			V				V		V			V
PDE2A			V		V		V		V		V
CA2			V				V					V
CA9			V
CA12			V				V					V
B3GNT3			V				V
LARGE2			V
LIAS			V
SMS			V				V					V
CYP26B1			V
NAT8L			V		V		V		V
XYLT2			V
DGKK			V
BPNT1			V				V
ACADL			V
ACOX2			V		V		V		V
ETNK1			V		V		V		V		V
ASAH2			V				V					V
CYP2J2			V		V		V		V
PTGS2			V		V		V		V		V
CD38			V		V
MAN1A1			V		V		V		V
ST6GAL1			V		V				V
GALNT6			V		V		V		V
GALNT14			V		V		V		V		V
PNPO			V
SORD			V
ODC1			V		V
DHFR2			V				V					V
QDPR			V				V		V
UQCRHL			V
UQCRH			V
ATP5MC1			V		V		V		V
ATP6V1B2			V
ATP6V0E1			V		V		V		V		V
NDUFA9			V		V				V
NDUFC2			V
CTH				V		V				V
PDXK				V
ELOVL6				V		V				V
GLUL				V				V			V
PTEN				V		V
ASPA				V				V
ALDH4A1				V							V
PDE7B				V		V
ACACA				V
MGAT4A				V		V		V		V		V
MGAT4D				V				V			V
B4GALT2				V		V		V		V
CHIT1				V
HMGCS2				V				V
XYLB				V
MMUT				V		V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
AKR1C4				V		V		V		V		V
SGMS2				V		V				V
SMPD3				V	V				V		V
GALC				V							V
AASS				V		V
AGL				V		V				V		V
GCNT1				V		V				V
CSGALNACT1				V		V				V		V
SARDH				V
ATP6V1G3				V
PPAT					V				V		V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
ALDH1A3					V
AOC3					V
MTMR4					V		V		V
PLCD4					V
INPP5K					V						V
ITPKB					V				V
IPPK					V
GOT2					V
GCAT					V
UGT2B7					V				V		V
UGT2B10					V				V		V
PNP					V
PDE1C					V				V		V
MOCS1					V				V		V
HDDC3					V		V		V
ATIC					V
TIGAR					V
KHK					V				V
ALG1					V
ELOVL1					V
MGAM					V				V		V
RXYLT1					V
DHCR24					V						V
NAGK					V
RIMKLA					V		V		V
RIMKLB					V				V
DGKA					V
IDO1					V				V		V
DCXR					V				V
CMAS					V				V
DNMT3B					V				V
SAT1					V				V		V
HSD17B2					V				V		V
FBP2					V						V
PLA2G4C					V				V		V
CERS1					V				V		V
GALNT18					V				V		V
ST3GAL1					V
NAGS					V				V		V
ALG3					V				V
ACOT2					V				V		V
ACOT1					V				V		V
DHRS9					V				V		V
PIGF					V				V		V
GCH1					V
DGUOK					V		V		V		V
AMDHD2					V						V
ALG10B					V				V		V
UQCRQ					V
ATP6V0E2					V				V
ATP5F1D					V				V		V
ATP6V0A1					V
NDUFB9					V
FKTN						V				V
PLD1						V				V
DLD						V		V		V		V
BCKDHA						V
HACD1						V
SCP2						V				V
RRM2B						V				V
GSTM2						V				V		V
GSTM4						V		V		V
GPX7						V						V
GLS						V		V		V		V
MTR						V
ALDH2						V				V		V
PIK3CA						V				V
SACM1L						V				V
PIK3C2B						V	V					V
MTM1						V		V		V
MTMR6						V		V		V
HNMT						V				V		V
NOS3						V				V
BCAT1						V			V
ENPP1						V		V		V
NT5E						V		V		V
CA5B						V				V		V
ALG13						V						V
CHPT1						V	V					V
AK4						V
AKR1B1						V				V		V
AKR1B10						V				V		V
HIBCH						V				V		V
GGPS1						V				V		V
GFPT1						V				V		V
FPGT						V				V
RGN						V				V		V
ASS1						V				V
AMD1						V		V		V
ASNS						V
MSMO1						V
FBP1						V				V
ME1						V				V		V
CMPK1						V				V
CDS1						V	V					V
MBOAT2						V				V
AGPAT5						V				V
AGPAT3						V				V		V
AGPS						V				V
EPHX2						V				V
CYP2U1						V
PTGS1						V				V		V
TBXAS1						V						V
NUDT12						V				V		V
NADK						V				V		V
STT3B						V				V
GALNT1						V
GALNT2						V						V
GALNT3						V
GALNT7						V				V		V
GALNT12						V				V		V
UGCG						V				V
B3GNT5						V		V		V		V
HLCS						V
ACSM3						V
PCK2						V
SUCLA2						V				V
NAMPT						V				V
PIGK						V				V		V
C1GALT1						V				V
ISYNA1						V				V		V
ECHDC1						V				V
H6PD						V						V
ATP6V0A4						V
ATP6V1A						V
NDUFA5						V				V		V
TKFC							V		V
GSTA3							V
GSTA4							V		V
GGT1							V		V
IMPA2							V
FHIT							V		V
NME1							V		V
A4GALT							V
DNMT3A							V
ACAT1							V
NAPRT							V
CHSY3							V		V
ABO							V
ST3GAL5							V
HAO1							V		V
MPI							V		V
SPAM1							V		V
GBGT1								V
PGM3								V		V
CBS								V
MAT2A								V
ACSL6								V		V
LSS								V
LPCAT2								V		V
CSGALNACT2								V
ACLY								V
HSD17B8									V
AOC2									V		V
INPP5F									V
PLCE1									V
ADCY1									V
NUDT16									V		V
NTPCR									V
SHPK									V
ELOVL7									V
LRTOMT									V
HSD17B6									V
SPTLC2									V		V
CYP4F2									V
NMNAT2									V
ALG8									V
GALNT13									V
GALNT9									V
PIGY									V
ACSM4									V
ENO3									V
COQ6									V		V
ABHD14A-ACY1									V
ACY1									V
NDUFA3									V
NDUFB1									V
GPX8										V
SYNJ1										V
SYNJ2										V
IPMK										V
IMPA1										V		V
ACADM										V
DDO										V
NT5C2										V
ADCY5										V
GFPT2										V		V
ADH6										V		V
RPEL1										V		V
MBOAT1										V		V
ALOX12										V
ST3GAL2										V
CHPF2										V
CPOX										V
ACSM1										V
PRPS2										V
TRAK2										V
NMRK1										V
G6PD										V
COX7A2										V		V
ITPK1											V
PLPP3											V
COMT											V
DLAT												V
ST8SIA1												V
PSPH												V
SMPD4												V
ATP12A												V
+ 01200: Carbon metabolism	0	0.5	0	0.2	0	0.3	0.1	0	0	0.2	0.1	0.6
ALDOC		V		V					V		V
IDH2		V				V
ACSS1		V		V		V
MMUT				V		V
FBP2					V						V
GOT2					V
FBP1						V				V
H6PD						V						V
DLD						V		V		V		V
SUCLA2						V				V
ME1						V				V		V
RGN						V				V		V
HIBCH						V				V		V
ACAT1							V
TKFC							V		V
HAO1							V		V
ENO3									V
RPEL1										V		V
G6PD										V
PRPS2										V
DLAT												V
PSPH												V
+ 01210: 2-Oxocarboxylic acid metabolism	0	0.9	0	0	1	0.6	0	0	2.1	0	0.8	0
IDH2		V				V
GOT2					V
NAGS					V				V		V
BCAT1						V			V
ABHD14A-ACY1									V
ACY1									V
+ 01212: Fatty acid metabolism	0	1.3	0.3	1.8	0.1	0.6	0.7	1	0.3	0.6	0	0
HADH		V
SCD		V		V		V
SCD5		V					V		V
CPT1A			V		V		V
ACADL			V
ELOVL6				V		V				V
ACACA				V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
ELOVL1					V
HACD1						V
SCP2						V				V
ACAT1							V
ACSL6								V		V
HSD17B8									V
ELOVL7									V
ACADM										V
+ 01230: Biosynthesis of amino acids	0	1	0	0.6	0	0.3	0	0.7	1	0	0.8	0
ALDOC		V		V					V		V
IDH2		V				V
ARG2		V					V		V
CTH				V		V				V
GLUL				V				V			V
GOT2					V
NAGS					V				V		V
BCAT1						V			V
MTR						V
ASS1						V				V
ASNS						V
MAT2A								V
CBS								V
ENO3									V
ABHD14A-ACY1									V
ACY1									V
RPEL1										V		V
PRPS2										V
PSPH												V
+ 1.1 Carbohydrate metabolism	0.9	2.4	1.7	1.9	1.8	2.8	1.7	1.5	1.4	2.4	2.2	2.7
+ 00010: Glycolysis / Gluconeogenesis	0	1.6	0.1	0.3	0.1	0.7	0.2	0.1	0	0.2	0.5	0.7
ALDOC		V		V					V		V
ALDH7A1		V				V	V
ALDH3B1		V
ACSS1		V		V		V
G6PC3			V			V	V			V		V
ALDH1A3					V
FBP2					V						V
ALDH2						V				V		V
FBP1						V				V
DLD						V		V		V		V
PCK2						V
ENO3									V
ADH6										V		V
DLAT												V
+ 00020: Citrate cycle (TCA cycle)	0	0.6	0	0	0	0.9	0	1	0	0.2	0	0.5
IDH2		V				V
DLD						V		V		V		V
SUCLA2						V				V
PCK2						V
ACLY								V
DLAT												V
+ 00030: Pentose phosphate pathway	0	0.6	0	0.4	0.2	0.5	0	0	0.1	1.3	1.1	1
ALDOC		V		V					V		V
FBP2					V						V
FBP1						V				V
RGN						V				V		V
H6PD						V						V
PRPS2										V
RPEL1										V		V
G6PD										V
+ 00040: Pentose and glucuronate interconversions	1.7	0	2.4	0.3	1.8	0.2	0	0.4	1.2	1.1	1.6	1.7
KL	V							V
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
UGT2B11			V		V
UGT2B28			V		V				V		V
SORD			V
XYLB				V
DCXR					V				V
UGT2B7					V				V		V
UGT2B10					V				V		V
AKR1B1						V				V		V
AKR1B10						V				V		V
RPEL1										V		V
+ 00051: Fructose and mannose metabolism	0	0.5	0.3	0.3	0.9	0.8	0.8	0	1.2	0.7	1	0.4
ALDOC		V		V					V		V
SORD			V
KHK					V				V
TIGAR					V
FBP2					V						V
AKR1B1						V				V		V
AKR1B10						V				V		V
FPGT						V				V
FBP1						V				V
MPI							V		V
TKFC							V		V
+ 00052: Galactose metabolism	0	0	0.3	0.4	0.2	0.9	0.3	0.4	0.1	0.8	0.5	0.9
G6PC3			V			V	V			V		V
B4GALT2				V		V		V		V
MGAM					V				V		V
AKR1B1						V				V		V
AKR1B10						V				V		V
+ 00053: Ascorbate and aldarate metabolism	1.3	0.6	2.2	0	1.7	0.6	0.4	0	1	1	1.9	1.6
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
ALDH7A1		V				V	V
UGT2B11			V		V
UGT2B28			V		V				V		V
UGT2B7					V				V		V
UGT2B10					V				V		V
RGN						V				V		V
ALDH2						V				V		V
+ 00500: Starch and sucrose metabolism	0	0.5	0.2	0.8	0.1	0.7	0.2	0.3	0.1	0.6	0.4	0.8
GYG2		V		V		V				V		V
G6PC3			V			V	V			V		V
AGL				V		V				V		V
MGAM					V				V		V
ENPP1						V		V		V
+ 00520: Amino sugar and nucleotide sugar metabolism	0.3	0	0.1	0.2	0.5	0.2	0.1	0.6	0.2	0.9	0.3	0.2
CYB5R2	V		V							V
CHIT1				V
NAGK					V
AMDHD2					V						V
CMAS					V				V
GFPT1						V				V		V
CYB5R4						V		V		V
FPGT						V				V
MPI							V		V
PGM3								V		V
GFPT2										V		V
+ 00620: Pyruvate metabolism	0	1.1	0	0.7	0	1.3	0.6	0.3	0	0.3	0	1.1
ACSS1		V		V		V
ALDH7A1		V				V	V
ACACA				V
PCK2						V
ME1						V				V		V
ALDH2						V				V		V
DLD						V		V		V		V
ACAT1							V
DLAT												V
+ 00630: Glyoxylate and dicarboxylate metabolism	0	0.6	0	1.6	0	0.6	0.9	1.1	0.1	0.1	0.5	0.2
ACSS1		V		V		V
MMUT				V		V
GLUL				V				V			V
DLD						V		V		V		V
HAO1							V		V
ACAT1							V
+ 00640: Propanoate metabolism	0	1.2	0	1.4	0.1	2	0.8	0.4	0.1	0.7	0	0.4
ACSS3		V			V		V		V
ACSS1		V		V		V
ACACA				V
MMUT				V		V
HIBCH						V				V		V
ECHDC1						V				V
SUCLA2						V				V
DLD						V		V		V		V
BCKDHA						V
ACAT1							V
+ 00650: Butanoate metabolism	0	1.3	0	0.4	0	0.1	0.9	0.5	0.5	0.1	0	0.2
HADH		V
ALDH5A1		V					V		V			V
HMGCS2				V				V
ACSM3						V
ACAT1							V
ACSM4									V
ACSM1										V
+ 00562: Inositol phosphate metabolism	0	0.5	0.8	0.3	1.3	1	1.2	0.7	0.5	1.2	0.4	0.6
PI4K2B		V				V						V
PIK3C2A		V		V		V		V		V
PLCB1			V				V					V
PLCG2			V
PIK3CG			V		V		V		V
FIG4			V		V
PTEN				V		V
INPP5K					V						V
ITPKB					V				V
MTMR4					V		V		V
PLCD4					V
IPPK					V
MTM1						V		V		V
ISYNA1						V				V		V
MTMR6						V		V		V
PIK3CA						V				V
PIK3C2B						V	V					V
SACM1L						V				V
IMPA2							V
PLCE1									V
INPP5F									V
SYNJ1										V
SYNJ2										V
IPMK										V
IMPA1										V		V
ITPK1											V
+ 1.2 Energy metabolism	0	0	2.4	0.4	0.4	0.4	1.4	0.4	0.2	0.1	0.6	0.9
+ 00190: Oxidative phosphorylation	0	0	1.2	0	0.7	0	0.2	0	0.3	0	0.2	0
COX7B2	V		V		V		V		V		V
NDUFC2			V
NDUFA9			V		V				V
UQCRHL			V
UQCRH			V
ATP5MC1			V		V		V		V
ATP6V1B2			V
ATP6V0E1			V		V		V		V		V
ATP6V1G3				V
NDUFB9					V
UQCRQ					V
ATP6V0E2					V				V
ATP5F1D					V				V		V
ATP6V0A1					V
NDUFA5						V				V		V
ATP6V0A4						V
ATP6V1A						V
LHPP						V				V		V
PPA2							V
NDUFB1									V
NDUFA3									V
COX7A2										V		V
ATP12A												V
+ 00910: Nitrogen metabolism	0	0	2.1	0.7	0	0.2	1.4	0.7	0	0.2	0.8	1.6
CA2			V				V					V
CA9			V
CA12			V				V					V
GLUL				V				V			V
CA5B						V				V		V
+ 00920: Sulfur metabolism	0	0	0.9	0	0	0.4	0.9	0	0	0	0	0
BPNT1			V				V
SELENBP1						V
+ 1.3 Lipid metabolism	2.4	3.8	2.3	2.7	2.9	2	3	2.3	2.8	1.7	3.2	1.2
+ 00061: Fatty acid biosynthesis	0	0	0	2.1	0	0.6	0	2.2	0.3	1.1	0	0
ACACA				V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
ACSL6								V		V
HSD17B8									V
+ 00062: Fatty acid elongation	0	0.6	0	0.4	1.1	0.3	0	0	1	0.1	1.2	0
HADH		V
ELOVL6				V		V				V
ACOT2					V				V		V
ACOT1					V				V		V
ELOVL1					V
HACD1						V
ELOVL7									V
+ 00071: Fatty acid degradation	0	1	0.5	0.6	0.1	0.4	1	1.2	0	1	0	0.2
HADH		V
ALDH7A1		V				V	V
ACADL			V
CPT1A			V		V		V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
ALDH2						V				V		V
ACAT1							V
ACSL6								V		V
ACADM										V
ADH6										V		V
+ 00072: Synthesis and degradation of ketone bodies	0	0	0	1	0	0	0.9	1	0	0	0	0
HMGCS2				V				V
ACAT1							V
+ 00100: Steroid biosynthesis	1.6	0.8	1.3	0	1.5	0.2	0.6	0.7	0.3	0	0.7	0
CYP27B1	V		V		V
CYP24A1	V		V		V
TM7SF2		V					V		V
DHCR24					V						V
MSMO1						V
LSS								V
+ 00120: Primary bile acid biosynthesis	0.8	0	0.6	0.7	1	0.6	0.6	0.7	0.3	0.6	0	0.4
CH25H	V				V
ACOX2			V		V		V		V
AKR1C4				V		V		V		V		V
SCP2						V				V
+ 00140: Steroid hormone biosynthesis	3.1	0.7	2.4	2.2	2	0.6	0	2.3	2.2	1.7	2.5	1.2
HSD3B1	V		V		V			V		V
HSD3B2	V		V		V
CYP1A1	V		V		V				V
AKR1C3	V			V		V		V		V		V
HSD11B1	V							V		V
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
CYP11B2		V		V					V		V
CYP1A2		V		V		V
UGT2B11			V		V
UGT2B28			V		V				V		V
STS				V		V				V
AKR1C4				V		V		V		V		V
AKR1C1				V		V		V		V		V
HSD17B2					V				V		V
UGT2B7					V				V		V
UGT2B10					V				V		V
CYP1B1						V		V		V		V
HSD17B8									V
HSD17B6									V
LRTOMT									V
AKR1C2										V
COMT											V
+ 00561: Glycerolipid metabolism	0.2	0.7	0.3	0	0.1	1.1	1.1	0	0	0.7	0.2	1.2
LIPG	V		V		V
PLPP4		V				V	V					V
ALDH7A1		V				V	V
DGKK			V
DGKA					V
MBOAT2						V				V
AGPAT5						V				V
AGPAT3						V				V		V
AKR1B1						V				V		V
AKR1B10						V				V		V
ALDH2						V				V		V
TKFC							V		V
LPL							V
MBOAT1										V		V
PLPP3											V
+ 00564: Glycerophospholipid metabolism	0.6	0.7	0.5	0	0.3	0.7	1.1	0.2	0	0.6	0.5	0.7
PTDSS1	V		V		V					V		V
ACHE	V
PLA2G4A	V		V		V		V		V
PLAAT3		V					V
PLA2G5		V				V
PLPP4		V				V	V					V
ETNK1			V		V		V		V		V
DGKK			V
PLA2G4C					V				V		V
DGKA					V
CHPT1						V	V					V
PLD1						V				V
MBOAT2						V				V
AGPAT5						V				V
AGPAT3						V				V		V
GPD2						V				V		V
CDS1						V	V					V
LPGAT1						V				V
LPCAT2								V		V
LCAT								V
MBOAT1										V		V
LYPLA1										V
PLPP3											V
+ 00565: Ether lipid metabolism	0.3	2.1	0.5	0	0.5	0.4	1	0.2	0.2	0.2	0.8	0
PLA2G4A	V		V		V		V		V
PLA2G7		V
PLAAT3		V					V
PLA2G5		V				V
UGT8		V
GDPD1			V		V
PLA2G4C					V				V		V
AGPS						V				V
CHPT1						V	V					V
PLD1						V				V
LPCAT2								V		V
PLPP3											V
+ 00600: Sphingolipid metabolism	0.8	1.5	0.9	1.6	0.9	0.2	0.9	0	2.3	0	3.8	0.2
NEU4	V		V		V
SPHK1	V		V		V				V		V
CERS6		V					V		V
UGT8		V
B4GALT6		V					V		V
ASAH2			V				V					V
SMPD3				V	V				V		V
GALC				V							V
ARSA				V					V		V
SGMS2				V		V				V
CERS1					V				V		V
SGPP1						V
UGCG						V				V
SGPP2									V		V
SPTLC2									V		V
PLPP3											V
SMPD4												V
+ 00590: Arachidonic acid metabolism	0.6	1.7	0.6	0.4	0.5	1.1	1.5	0.1	1	0.5	0.5	0.8
PLA2G4A	V		V		V		V		V
AKR1C3	V			V		V		V		V		V
PLAAT3		V					V
PLA2G5		V				V
ALOX5		V		V		V				V		V
PTGES		V
CYP2J2			V		V		V		V
PTGS2			V		V		V		V		V
PLA2G4C					V				V		V
EPHX2						V				V
CYP2U1						V
GPX7						V						V
PTGS1						V				V		V
TBXAS1						V						V
GGT1							V		V
CYP4F2									V
GPX8										V
ALOX12										V
+ 00591: Linoleic acid metabolism	0.6	2.1	0.9	0.4	1.1	0.3	1.5	0	1	0	0.5	0
PLA2G4A	V		V		V		V		V
CYP1A2		V		V		V
PLAAT3		V					V
PLA2G5		V				V
CYP2J2			V		V		V		V
PLA2G4C					V				V		V
+ 00592: alpha-Linolenic acid metabolism	0.6	1.5	0.4	0	0.7	0.1	1.1	0	0.6	0	0.6	0
PLA2G4A	V		V		V		V		V
PLAAT3		V					V
PLA2G5		V				V
PLA2G4C					V				V		V
+ 01040: Biosynthesis of unsaturated fatty acids	0	1.4	0	1.1	1.1	1.1	0.4	0	1.5	0.3	1.2	0
SCD		V		V		V
SCD5		V					V		V
ELOVL6				V		V				V
ACOT2					V				V		V
ACOT1					V				V		V
ELOVL1					V
HACD1						V
SCP2						V				V
ELOVL7									V
+ 1.4 Nucleotide metabolism	0.2	0.5	0.5	0	0.4	0.3	1.8	0.5	1.3	0.4	0.8	0
+ 00230: Purine metabolism	0.1	0.4	0.4	0	0.5	0	2.2	0.2	1.7	0	1.2	0
PDE10A	V			V		V		V		V
GUCY1A1	V										V
PDE3B		V					V		V
PDE9A		V					V					V
PDE4D		V					V
PDE11A			V				V		V			V
PDE2A			V		V		V		V		V
ENTPD3			V
NT5C			V				V		V
ENPP4			V		V		V		V			V
PDE7B				V		V
PPAT					V				V		V
ATIC					V
PDE1C					V				V		V
PNP					V
HDDC3					V		V		V
DGUOK					V		V		V		V
RRM2B						V				V
AK4						V
NT5E						V		V		V
ENPP1						V		V		V
NME1							V		V
FHIT							V		V
ADCY1									V
NTPCR									V
NUDT16									V		V
PRPS2										V
ADCY5										V
NT5C2										V
+ 00240: Pyrimidine metabolism	0.2	0.3	0.3	0	0	0.4	0.3	0.5	0.1	0.6	0	0
CMPK2	V									V		V
UPP1		V				V
ENTPD3			V
NT5C			V				V		V
PNP					V
RRM2B						V				V
CMPK1						V				V
NT5E						V		V		V
ENPP1						V		V		V
NME1							V		V
NT5C2										V
+ 1.5 Amino acid metabolism	1.7	3.4	2.1	1.6	3.2	2.8	2.8	2.4	2.8	2.6	1.8	2
+ 00250: Alanine, aspartate and glutamate metabolism	0.4	1.1	0.7	1.4	2.2	0.7	1.8	1.5	2	1.4	1.6	1.2
IL4I1	V									V
ASRGL1		V	V		V		V		V
ALDH5A1		V					V		V			V
NAT8L			V		V		V		V
GLUL				V				V			V
ALDH4A1				V							V
ASPA				V				V
GOT2					V
PPAT					V				V		V
RIMKLA					V		V		V
RIMKLB					V				V
ASNS						V
ASS1						V				V
GLS						V		V		V		V
GFPT1						V				V		V
DDO										V
GFPT2										V		V
+ 00260: Glycine, serine and threonine metabolism	0	0.4	0.6	0.7	0.7	0.6	0.6	0.8	0.2	0.2	0.3	0.6
ALDH7A1		V				V	V
MAOA			V		V		V		V
MAOB			V			V				V		V
CTH				V		V				V
SARDH				V
GCAT					V
AOC3					V
DLD						V		V		V		V
CBS								V
AOC2									V		V
PSPH												V
+ 00270: Cysteine and methionine metabolism	0.8	0.3	0.1	0.2	0.2	0.6	0.5	1.1	0.4	0.3	0	0.2
IL4I1	V									V
GCLM	V					V				V		V
MTAP		V							V
SMS			V				V					V
CTH				V		V				V
DNMT3B					V				V
GOT2					V
AMD1						V		V		V
MTR						V
BCAT1						V			V
DNMT3A							V
CBS								V
MAT2A								V
+ 00280: Valine, leucine and isoleucine degradation	0.3	0.9	0	0.6	0	1.3	0.5	0.6	0	0.6	0	0.5
IL4I1	V									V
HADH		V
ALDH7A1		V				V	V
HMGCS2				V				V
MMUT				V		V
BCKDHA						V
DLD						V		V		V		V
BCAT1						V			V
ALDH2						V				V		V
HIBCH						V				V		V
ACAT1							V
ACADM										V
+ 00290: Valine, leucine and isoleucine biosynthesis	0	0	0	0	0	0.9	0	0	1.1	0	0	0
BCAT1						V			V
+ 00310: Lysine degradation	0	1.3	0	1.3	0	1.2	0.7	0.5	0.1	1.1	0.2	0.9
HADH		V
ALDH7A1		V				V	V
NSD2		V					V		V
AASS				V		V
SETD2				V		V				V
KMT2C				V		V		V		V
PLOD2				V
CAMKMT					V				V
DLD						V		V		V		V
KMT5B						V				V		V
ASH1L						V				V		V
ALDH2						V				V		V
ACAT1							V
SUV39H2										V		V
SETD7										V
EZH1											V
+ 00220: Arginine biosynthesis	0.7	0.8	0	0.6	0.8	0.9	0.5	2.1	1.9	1.4	1.4	0.3
NOS1	V							V		V
ARG2		V					V		V
GLUL				V				V			V
NAGS					V				V		V
GOT2					V
GLS						V		V		V		V
ASS1						V				V
NOS3						V				V
ABHD14A-ACY1									V
ACY1									V
+ 00330: Arginine and proline metabolism	0.3	0.9	1.4	0.2	0.8	0.6	1.4	0.6	0.4	0.5	0.7	0.4
NOS1	V							V		V
ARG2		V					V		V
ALDH7A1		V				V	V
SMS			V				V					V
MAOA			V		V		V		V
MAOB			V			V				V		V
ODC1			V		V
ALDH4A1				V							V
SAT1					V				V		V
GOT2					V
ALDH2						V				V		V
AMD1						V		V		V
NOS3						V				V
+ 00340: Histidine metabolism	0	1.6	1.1	0.5	0.8	1.4	1.1	0.6	0.2	0.8	0	1.3
ALDH7A1		V				V	V
ALDH3B1		V
MAOA			V		V		V		V
MAOB			V			V				V		V
ASPA				V				V
ALDH1A3					V
ALDH2						V				V		V
HNMT						V				V		V
+ 00350: Tyrosine metabolism	0.4	1.2	0.7	0	1.3	0	0.7	0	1.1	0.3	1	0.4
IL4I1	V									V
ALDH3B1		V
TYR		V					V		V
MAOA			V		V		V		V
MAOB			V			V				V		V
GOT2					V
ALDH1A3					V
AOC3					V
AOC2									V		V
LRTOMT									V
ADH6										V		V
COMT											V
+ 00360: Phenylalanine metabolism	0.9	1.8	1.4	0	2.4	0.2	0.6	0	1.6	1.2	0.8	0.4
IL4I1	V									V
ALDH3B1		V
GLYAT		V							V	V
MAOA			V		V		V		V
MAOB			V			V				V		V
ALDH1A3					V
AOC3					V
GOT2					V
AOC2									V		V
+ 00380: Tryptophan metabolism	0.9	2.2	1.6	0.2	1.1	1.5	1.6	0.8	0.9	0.7	0.3	1
IL4I1	V									V
CYP1A1	V		V		V				V
HADH		V
CYP1A2		V		V		V
HAAO		V				V
ALDH7A1		V				V	V
MAOA			V		V		V		V
MAOB			V			V				V		V
KYNU			V		V		V		V
IDO1					V				V		V
CYP1B1						V		V		V		V
DLD						V		V		V		V
ALDH2						V				V		V
ACAT1							V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	1.5	0	0	0	1.1	0	0	0	0	0.8	0	0
IL4I1	V									V
GOT2					V
+ 1.6 Metabolism of other amino acids	0.1	1.2	0.9	0.3	0.6	1.3	2.2	0.9	1.5	0.8	0.6	1.7
+ 00410: beta-Alanine metabolism	0	1.2	0.3	0	0.5	0.5	0.8	0	0.1	0.2	0.4	0.9
ALDH7A1		V				V	V
ALDH3B1		V
SMS			V				V					V
AOC3					V
ALDH1A3					V
HIBCH						V				V		V
ALDH2						V				V		V
AOC2									V		V
+ 00430: Taurine and hypotaurine metabolism	0	1.1	0.8	0	0	0	1.7	0	1.3	0	0	0.6
GGT7		V	V				V		V			V
GGT1							V		V
+ 00440: Phosphonate and phosphinate metabolism	0	0	0	0	0	0.7	1.2	0	0	0	0	0.9
CHPT1						V	V					V
+ 00450: Selenocompound metabolism	0	0	0	0.7	0.4	0.6	0	0.7	0.9	0.6	0	0
CTH				V		V				V
PSTK					V				V
MTR						V
TXNRD1								V		V
TXNRD2									V
+ 00471: D-Glutamine and D-glutamate metabolism	0	0	0	0	0	0.8	0	1.4	0	0.8	0	1
GLS						V		V		V		V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0	0	0	0	0	0	0	0
+ 00480: Glutathione metabolism	0.2	0.7	1.2	0	0.7	0.7	2.1	0.2	1.6	0.6	1.1	1
GCLM	V					V				V		V
GGT7		V	V				V		V			V
IDH2		V				V
MGST2			V				V		V
ODC1			V		V
SMS			V				V					V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
GPX7						V						V
GSTM2						V				V		V
GSTM4						V		V		V
RRM2B						V				V
GGT1							V		V
GSTA3							V
GSTA4							V		V
GPX8										V
G6PD										V
+ 1.7 Glycan biosynthesis and metabolism	0.7	2.3	1.9	1.6	1.9	2	2.8	1.6	2	1.5	1.1	2
+ 00510: N-Glycan biosynthesis	0	0.3	0.5	1	1.2	0.3	0.1	1.1	1.4	0.1	0.7	0.2
ST6GAL2		V							V
ST6GAL1			V		V				V
MAN1A1			V		V		V		V
B4GALT2				V		V		V		V
MGAT4A				V		V		V		V		V
MGAT4D				V				V			V
ALG3					V				V
ALG1					V
ALG10B					V				V		V
STT3B						V				V
ALG13						V						V
ALG8									V
+ 00512: Mucin type O-glycan biosynthesis	0	0	0.9	0.4	1.5	2.2	0.9	0	1.8	1.3	1.1	1
GALNT6			V		V		V		V
GALNT14			V		V		V		V		V
GCNT1				V		V				V
ST3GAL1					V
GALNT18					V				V		V
GALNT1						V
GALNT2						V						V
GALNT3						V
GALNT7						V				V		V
GALNT12						V				V		V
C1GALT1						V				V
GALNT13									V
GALNT9									V
ST3GAL2										V
+ 00515: Mannose type O-glycan biosynthesis	0	0	0.5	0.5	0.3	0.4	0	0.6	0	0.4	0	0
LARGE2			V
B4GALT2				V		V		V		V
RXYLT1					V
FKTN						V				V
+ 00514: Other types of O-glycan biosynthesis	0	2.3	0.5	1.2	0.3	1.4	1.1	0.6	0.7	0.4	0	1.3
ST6GAL2		V							V
LFNG		V				V	V					V
GXYLT2		V				V	V					V
ST6GAL1			V		V				V
B4GALT2				V		V		V		V
GXYLT1				V		V				V		V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	0	1.3	1.4	0.4	0.5	1.3	0.7	0.8	0.5	0	0.3
XYLT2			V
UST			V		V		V		V
CSGALNACT1				V		V				V		V
CHST15				V		V
CHSY3							V		V
CSGALNACT2								V
CHPF2										V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.7	1.6	1.1	0	0.3	0.4	0.5	0	0.7	0.4	0.6	0.8
HS3ST2	V		V							V		V
NDST4		V
HS2ST1		V				V	V		V
XYLT2			V
HS6ST3					V				V		V
HS6ST1						V				V		V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	0	0.7	0.8	0.5	0.3	1.5	0.8	0	0.8	0	0.5
CHST4			V				V					V
B4GALT2				V		V		V		V
ST3GAL1					V
CHST2							V
ST3GAL2										V
+ 00531: Glycosaminoglycan degradation	0	2.5	0	0	0	0.2	1.3	0	0.3	0	0	0
HPSE		V				V	V
IDUA		V
NAGLU		V
SPAM1							V		V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	0.7	0	0	0.3	0.8	0.5	0	0.7	0.8	0.6	1.3
GPLD1		V				V	V			V		V
PIGF					V				V		V
PIGK						V				V		V
PIGZ						V				V		V
PIGY									V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0	0	0.4	0.5	0	0.3	1.6	1.2	0	0.3	0	0.6
B3GNT3			V				V
B4GALT2				V		V		V		V
B3GNT5						V		V		V		V
ABO							V
A4GALT							V
ST8SIA1												V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0	0	0.5	0	0.7	0.8	0	0.2	0	0.4
ST3GAL1					V
A4GALT							V
GBGT1								V
ST3GAL2										V
ST8SIA1												V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0.9	0	0.7	0	1.1	0	0.7	0	0.4	0.2	0.9	0.4
ST6GALNAC5	V		V		V				V		V
ST3GAL1					V
ST3GAL5							V
ST3GAL2										V
ST8SIA1												V
+ 00511: Other glycan degradation	0.8	0.9	0.6	0	0.4	0.2	0	0	0.3	0.2	0	0.4
NEU4	V		V		V
HEXD		V							V
FUCA1						V				V		V
+ 1.8 Metabolism of cofactors and vitamins	2	1.4	2.8	1.2	1.6	2	1.2	1.2	1.2	1.3	1.7	1.2
+ 00730: Thiamine metabolism	0.9	1	0	0.7	0.5	0.7	0	0	0.4	0	0.9	0
ALPL	V				V						V
ALPP		V		V		V
AK4						V
NTPCR									V
+ 00740: Riboflavin metabolism	0	0	0	0	0	0.6	0	1.1	0	0.5	0	0
ENPP1						V		V		V
+ 00750: Vitamin B6 metabolism	0	0	1.2	1.2	0	0	0	0	0	0	0	0
PNPO			V
PDXK				V
+ 00760: Nicotinate and nicotinamide metabolism	0.5	1.3	0.9	0.4	0.5	2.2	0.9	1	0.4	2.6	0	1
NMNAT1	V
NMNAT3		V				V				V		V
NNMT		V		V		V
CD38			V		V
NT5C			V				V		V
PNP					V
NUDT12						V				V		V
ENPP1						V		V		V
NAMPT						V				V
NADK						V				V		V
NT5E						V		V		V
NAPRT							V
NMNAT2									V
NMRK1										V
NT5C2										V
+ 00770: Pantothenate and CoA biosynthesis	0.8	0	0	0	0	0.5	0.6	1.4	0.3	0.5	0	0.3
VNN1	V							V		V
ENPP1						V		V		V
BCAT1						V			V
VNN2							V					V
+ 00780: Biotin metabolism	0	0	0	0	0	1.1	0	0	0	0	0	0
HLCS						V
+ 00785: Lipoic acid metabolism	0	0	1.5	0	0	0	0	0	0	0	0	0
LIAS			V
+ 00790: Folate biosynthesis	1.4	0.7	1	1.1	1.2	1.2	1	0.5	0.6	0.7	1.3	1.7
ALPL	V				V						V
AKR1C3	V			V		V		V		V		V
ALPP		V		V		V
DHFR2			V				V					V
QDPR			V				V		V
GCH1					V
MOCS1					V				V		V
AKR1B1						V				V		V
AKR1B10						V				V		V
+ 00670: One carbon pool by folate	0	0.8	0.5	0.6	0.3	0.5	1.2	0	0	0	0	0.3
ALDH1L1		V		V		V
DHFR2			V				V					V
ATIC					V
MTR						V
MTFMT							V
+ 00830: Retinol metabolism	1.5	1.1	2.6	0.1	1.5	0	0.6	0	1.3	0.1	1.4	0.7
CYP1A1	V		V		V				V
RDH16	V
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
LRAT		V	V		V		V		V
CYP1A2		V		V		V
DHRS3		V				V	V					V
CYP26B1			V
UGT2B11			V		V
UGT2B28			V		V				V		V
SDR16C5			V				V
DHRS9					V				V		V
UGT2B7					V				V		V
UGT2B10					V				V		V
HSD17B6									V
ADH6										V		V
AWAT2										V		V
+ 00860: Porphyrin and chlorophyll metabolism	0.9	0	2.1	0	1.5	0	0	0	0.5	0.2	1.4	0.3
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
UGT2B11			V		V
UGT2B28			V		V				V		V
HCCS			V
UGT2B7					V				V		V
UGT2B10					V				V		V
FXN					V
CPOX										V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	1.1	0	0	0	0	0	0	0	0.6	0	1.1	0
COQ3	V
COQ6									V		V
+ 1.9 Metabolism of terpenoids and polyketides	0	0	0	0.5	0.3	0.1	0.5	0.6	0.2	0.1	0.6	0.2
+ 00900: Terpenoid backbone biosynthesis	0	0	0	0.5	0.3	0.1	0.5	0.6	0.2	0.1	0.6	0.2
HMGCS2				V				V
ICMT					V				V		V
GGPS1						V				V		V
ACAT1							V
+ 1.10 Biosynthesis of other secondary metabolites	0	1.1	0	0.9	0	0.6	0	0	0	0	0	0
+ 00232: Caffeine metabolism	0	1.5	0	1.3	0	0.8	0	0	0	0	0	0
CYP1A2		V		V		V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.11 Xenobiotics biodegradation and metabolism	2	1	3.2	0.2	3.1	0.3	1.4	0.8	2.9	0.6	3.6	1
+ 00980: Metabolism of xenobiotics by cytochrome P450	1.8	1	2	0.3	1.9	0.3	0.4	1.1	1.7	0.6	2.1	0.8
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
CYP1A1	V		V		V				V
AKR7A3	V		V
HSD11B1	V							V		V
ALDH3B1		V
EPHX1		V				V
CYP1A2		V		V		V
MGST2			V				V		V
UGT2B11			V		V
UGT2B28			V		V				V		V
AKR1C1				V		V		V		V		V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
UGT2B7					V				V		V
UGT2B10					V				V		V
ALDH1A3					V
GSTM2						V				V		V
GSTM4						V		V		V
CYP1B1						V		V		V		V
GSTA3							V
GSTA4							V		V
ADH6										V		V
+ 00982: Drug metabolism - cytochrome P450	0.5	0.6	2.1	0.1	2	0.1	0.9	0.1	1.8	0.3	2.2	0.6
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
ALDH3B1		V
CYP1A2		V		V		V
MGST2			V				V		V
UGT2B11			V		V
UGT2B28			V		V				V		V
MAOA			V		V		V		V
MAOB			V			V				V		V
ALDH1A3					V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
UGT2B7					V				V		V
UGT2B10					V				V		V
GSTM2						V				V		V
GSTM4						V		V		V
GSTA3							V
GSTA4							V		V
ADH6										V		V
+ 00983: Drug metabolism - other enzymes	1.2	0.1	1.5	0	1.5	0.1	1.1	0.3	1.5	0.2	2	0.3
CES1	V		V		V		V					V
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
MPO	V							V
UPP1		V				V
UGT2B11			V		V
UGT2B28			V		V				V		V
MGST2			V				V		V
UGT2B7					V				V		V
UGT2B10					V				V		V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
CMPK1						V				V
RRM2B						V				V
GSTM2						V				V		V
GSTM4						V		V		V
NME1							V		V
GSTA3							V
GSTA4							V		V
+ 2. Genetic Information Processing	1.3	0.4	1.9	1.9	1.8	2	0.5	1.9	0.8	3.1	0.7	1.6
+ 2.1 Transcription	0.2	0.2	0.5	0.2	0.1	0.2	0.2	0.4	0.3	1.1	0.3	0.9
+ 03020: RNA polymerase	0	0	0.3	0.4	0.2	0	0	0.4	0.4	0.5	0.5	0
POLR1B			V
TWISTNB				V		V		V		V
POLR2C					V				V		V
POLR2I									V
POLR2J2										V
POLR2J3										V
+ 03022: Basal transcription factors	0.3	0.4	0.2	0	0	0	0.2	0.2	0	0.6	0	0.5
TBP	V		V							V		V
TAF5L		V					V
GTF2I						V				V		V
TAF12								V		V
TAF4B									V
TAF2										V
TAF8										V
TAF1L												V
+ 03040: Spliceosome	0.1	0	0.4	0	0	0.3	0.2	0.1	0	0.8	0	1
HSPA1B	V							V		V
ALYREF	V		V
SRSF1		V				V
HNRNPA1L2			V				V					V
HNRNPA1			V				V					V
HNRNPC			V				V					V
TRA2A			V				V					V
THOC2				V		V				V		V
PRPF19					V
WBP11					V
LSM3					V
SNU13					V				V
PRPF40A						V				V		V
SF3B1						V		V		V		V
U2SURP						V				V
HNRNPA3						V				V
HNRNPU						V				V		V
SRSF10						V
CDC5L						V				V
HSPA1A						V				V
THOC1						V				V
DHX16										V		V
SRSF3										V
CRNKL1										V
ISY1-RAB43										V
LSM5										V		V
SRSF2											V
LSM8												V
+ 2.2 Translation	1	0.1	1.4	0.7	1.7	0.9	0.4	1	0.8	1.6	0.5	0.4
+ 03010: Ribosome	0.3	0	1.5	0	2.5	0	0.1	0	1.3	0	0.1	0
RPS28	V		V			V				V		V
RPL27A	V		V		V
RPL10	V							V
RPL26			V		V
RPL22L1			V		V				V
RPL14			V									V
MRPL32			V
RPS2			V
RPSA			V
MRPS18C			V				V
RPS19				V
RPL13					V				V		V
RPS23					V				V
RPS24					V				V
RPS26					V
MRPL10					V
RPL9					V				V
RPL17					V				V
UBA52					V						V
RPL34					V				V
RPL6					V				V
RPL29					V
MRPL34					V				V
MRPS11					V				V
RPL37							V		V
RPL7A							V
RPL28									V
RPL41									V
RPLP0										V
+ 00970: Aminoacyl-tRNA biosynthesis	0.3	0	0	0	0.3	0.1	0.2	0	0.2	0.2	0.3	0.1
QRSL1	V
YARS2					V				V
PSTK					V				V
DARS						V				V		V
TARS						V				V
MTFMT							V
CARS										V
WARS											V
+ 03013: RNA transport	0.9	0.2	0.8	0.2	0.2	0.8	0.4	0.2	0	1.2	0	0.8
ALYREF	V		V
NUP43	V									V		V
NUP210	V		V		V		V					V
EEF1A1	V		V									V
PABPC1L2A	V							V		V
PABPC1L2B	V							V		V
TPR		V		V		V
PAIP1		V					V
CYFIP2		V	V		V		V		V
POP1			V		V
RPP25			V
ELAC2			V
THOC5			V
THOC2				V		V				V		V
UPF2				V		V				V
UPF3B				V		V		V		V
SAP18					V
PRMT5					V				V
EIF3G					V
POP4					V						V
POP5					V				V
XPO1						V
PNN						V						V
NXT2						V		V		V
RANBP2						V				V		V
SUMO1						V						V
EIF1AX						V				V
EIF3E						V				V
EIF3A						V				V		V
THOC1						V				V
EIF2S3						V				V		V
EIF5B						V				V
FMR1						V				V
FXR1						V				V
EEF1A2							V
PABPC1							V
PABPC3							V
GEMIN6									V
PABPC1L									V
EIF4E									V
NUP153										V		V
SUMO3										V		V
NMD3										V
NUP35										V
EIF1												V
+ 03015: mRNA surveillance pathway	0.7	0	0.1	1.1	0.1	1.1	0.3	1.6	0.1	2	0.6	0
ALYREF	V		V
PABPC1L2A	V							V		V
PABPC1L2B	V							V		V
MSI2			V		V		V		V		V
UPF3B				V		V		V		V
UPF2				V		V				V
PAPOLB				V				V
PPP2R3A				V		V
PPP1CB				V		V				V
SAP18					V
PPP2R2C					V				V		V
PNN						V						V
NXT2						V		V		V
SMG1						V		V		V
NUDT21						V				V
PCF11						V				V
CPSF6						V				V
HBS1L						V				V		V
PABPC1							V
PABPC3							V
CSTF3									V	V	V
PABPC1L									V
GSPT1										V
RNGTT										V
PAPOLA										V
+ 03008: Ribosome biogenesis in eukaryotes	0.1	0	0.7	0.2	0.8	0	0	0.3	0.1	0.2	0.1	0
FCF1	V		V							V		V
POP1			V		V
RPP25			V
EMG1			V		V				V
NOP10				V				V
XRN1				V		V				V
SNU13					V				V
POP4					V						V
POP5					V				V
GNL3L					V
XPO1						V
NXT2						V		V		V
MPHOSPH10						V
NMD3										V
NOP58										V		V
HEATR1										V
+ 2.3 Folding, sorting and degradation	1	0.4	0.5	0.8	1.5	1.5	0.1	1.3	0.1	2.3	0.2	1.2
+ 03060: Protein export	0	0	0.5	0.5	0.8	0.8	0	0.6	0	0.4	0	0.2
SRPRB			V		V
SEC62				V		V		V		V
SEC11C					V
SRP54						V
SRP9						V				V
SPCS3												V
+ 04141: Protein processing in endoplasmic reticulum	0	0.1	0	0.3	0	0.7	0.1	0.6	0	1.1	0	0.6
HSPA1B	V							V		V
STUB1		V		V			V		V		V
SVIP		V	V				V		V			V
MAN1A1			V		V		V		V
DNAJA2			V
EDEM3				V		V				V		V
UGGT2				V		V				V
SEC62				V		V		V		V
PRKN				V				V
DDIT3					V
UFD1					V
WFS1					V				V
DNAJB2					V
STT3B						V				V
SEC23A						V
SEC24A						V				V		V
LMAN1						V				V		V
ERO1B						V
MBTPS2						V
YOD1						V				V		V
HSPA1A						V				V
FBXO2						V				V		V
UBE2D1						V		V		V
DNAJC10						V				V		V
NFE2L2						V				V		V
HSPA4L						V						V
CRYAB						V				V
ATF4							V
HSP90AA1								V
HSPH1								V		V
UBE2D4									V
BAG1									V
EIF2AK2										V		V
UBE2J2										V
UBE2J1										V
PLAA										V
TRAM1										V
BAG2												V
+ 04130: SNARE interactions in vesicular transport	0	0	0.3	0.3	0.4	0.8	0	0	0.1	1.1	0	0.8
VAMP1			V		V
STX11				V
GOSR2					V				V
STX17						V				V
BET1						V				V		V
VAMP4						V				V		V
VAMP7						V				V		V
STX7										V
+ 04120: Ubiquitin mediated proteolysis	0.3	0.4	0	1.1	0	1.1	0.1	1.2	0	2	0.2	0.7
SKP2	V		V							V		V
CDC27	V		V							V		V
WWP2	V							V		V
FBXO4		V
CUL5		V		V		V				V		V
STUB1		V		V			V		V		V
CUL4B				V		V		V		V
MAP3K1				V		V		V		V
PRKN				V				V
UBA6				V		V				V		V
BIRC6				V		V
PRPF19					V
FBXO2						V				V		V
SOCS1						V
UBE2W						V				V
CUL2						V
XIAP						V				V
RCHY1						V				V		V
UBE2D1						V		V		V
UBA7						V				V
HERC1						V				V		V
UBE2Q2						V				V
UBE2H						V		V		V		V
SOCS3							V		V
ANAPC11							V		V
SMURF1								V
UBE2D4									V
UBA2										V
BRCA1										V
UBE2J1										V
UBE2J2										V
UBE2QL1										V		V
MID1											V
PPIL2											V
BIRC3												V
+ 04122: Sulfur relay system	1.2	0	0	0	1.7	0	0	0	0	0	0	0
CTU1	V				V
CTU2					V
+ 03050: Proteasome	0.3	0.4	0.5	0	0.6	0.1	0	0	0	0.2	0	0.5
ADRM1	V		V		V
PSMA1		V				V
POMP			V
PSMC5					V
PSME3					V
PSMB9						V				V		V
PSMD14										V		V
PSMB8										V
PSMD4												V
+ 03018: RNA degradation	0.8	0.1	0	0.1	0.6	0.7	0.2	1	0.2	1.3	0.4	0.3
PNLDC1	V							V		V
PABPC1L2A	V							V		V
PABPC1L2B	V							V		V
EXOSC9		V
XRN1				V		V				V
EXOSC4					V
CNOT1					V				V		V
LSM3					V
PARN					V
TOB1					V
TTC37						V				V		V
DIS3						V
MTREX						V
CNOT6L						V				V
DCP2						V		V		V
HSPA9						V				V		V
PAN3						V				V
PABPC1							V
PABPC3							V
ENO3									V
PABPC1L									V
NUDT16									V		V
CNOT4										V
LSM5										V		V
LSM8												V
+ 2.4 Replication and repair	0.3	0.1	1.3	2	0.3	1.4	0.2	1	0.4	1.1	0.3	0.6
+ 03030: DNA replication	0	0	0.2	0	0	0	0.2	0	0.1	0	0	0.1
POLD3			V									V
DNA2						V
RNASEH2C							V		V
+ 03410: Base excision repair	0	0	0.8	0	0	0	0	0	0	0	0	0.1
POLD3			V									V
NEIL2			V
HMGB1						V				V
+ 03420: Nucleotide excision repair	0	0	0.1	0.6	0	0.1	0	0.7	0	0	0	0
POLD3			V									V
CUL4B				V		V		V		V
ERCC6				V		V		V		V
+ 03430: Mismatch repair	0	0	0.5	0.5	0	0.1	0	0	0	0	0	0.2
POLD3			V									V
MLH3				V		V
+ 03440: Homologous recombination	0	0	1.1	1.2	0.3	0.8	0.2	0	0.5	0.2	0.9	0.6
RAD51C			V		V		V		V
POLD3			V									V
SYCP3			V									V
MRE11				V
ABRAXAS1				V		V
BRCC3				V		V				V
RAD54B					V	V			V	V	V
BRIP1						V
ATM						V
XRCC3									V		V
BRCA1										V
XRCC2												V
+ 03450: Non-homologous end-joining	0	0	0	1.7	0	0.9	0	0.9	0	1.4	0	0
LIG4				V		V		V		V
MRE11				V
DNTT						V
DCLRE1C										V
XRCC4										V
+ 03460: Fanconi anemia pathway	0.7	0.3	0.8	1.4	0.4	1.7	0.1	1	0.6	1.3	0	0.4
FANCD2	V									V
FANCG	V		V
POLI		V				V
RAD51C			V		V		V		V
POLH			V									V
ATR				V		V				V
USP1				V		V				V
POLK				V		V		V		V		V
REV3L				V		V		V		V
CENPS-CORT					V				V
POLN					V
FANCM						V
FANCB						V		V		V
RMI1						V				V		V
BRIP1						V
FAAP100									V
CENPX									V
BRCA1										V
+ 3. Environmental Information Processing	8.3	3.7	6.1	4	5.3	5.3	5.7	6.9	5.1	7.1	4	5.2
+ 3.1 Membrane transport	0.3	2.1	0.5	0.6	0.6	1	1	0.2	2	1	0.3	0.5
+ 02010: ABC transporters	0.3	2.1	0.5	0.6	0.6	1	1	0.2	2	1	0.3	0.5
ABCC5	V
ABCG1		V				V				V		V
ABCC6		V					V		V
ABCA3		V					V		V
ABCA1		V		V		V		V		V
ABCC9			V		V		V		V		V
DEFB1			V		V				V
TAP2				V		V
ABCG2					V				V
ABCD3						V				V
ABCC3						V				V		V
ABCB10						V				V		V
ABCB4									V
ABCB9									V
TAP1										V
+ 3.2 Signal transduction	6.9	2	5.9	5.5	4.5	6.6	4.5	6.2	3.4	7.2	4.9	4.2
+ 04010: MAPK signaling pathway	3.1	0.8	1.4	2.5	1.8	2	0.6	1.8	0.7	2.6	1.4	0.7
PTPRR	V		V		V
PLA2G4A	V		V		V		V		V
NFKB2	V									V
RELA	V		V		V
MAP3K14	V
PRKCB	V							V
NGFR	V					V				V		V
CACNA1H	V
CACNA1G	V							V
CACNA2D4	V		V		V				V		V
AKT2	V		V							V		V
MAP3K13	V									V
TNF	V							V		V
MAP3K3	V				V
MAP3K11	V									V		V
HSPA1B	V							V		V
FGF1	V				V
IGF1	V		V		V
NTF3	V			V		V		V		V
MAP4K4		V		V		V				V
CSF1R		V				V						V
MAP2K6		V					V
CD14		V		V		V
MAP3K2		V		V		V
RPS6KA2		V				V				V		V
AREG		V					V		V
BDNF		V		V		V
VEGFB		V
RASGRF2			V
DUSP1			V		V		V		V		V
DUSP2			V		V		V		V
DUSP3			V		V				V		V
MEF2C			V		V				V
IL1A			V		V
IL1B			V		V		V		V
MYC			V				V
EREG			V		V		V		V		V
TGFA			V		V		V		V			V
PDGFD			V		V		V		V
RASA1				V		V		V		V
NF1				V							V
PRKACB				V		V		V		V		V
SOS1				V		V				V
ELK4				V		V				V
ATF2				V		V		V		V		V
PPM1A				V		V
AKT3				V		V		V		V	V
MAP3K20				V				V		V
STK3				V		V				V
TGFB2				V		V				V
MAP3K1				V		V		V		V
RPS6KA3				V		V				V		V
ANGPT2				V							V
NGF				V		V				V
PLA2G4C					V				V		V
ERBB3					V						V
KDR					V				V
CACNB1					V				V		V
NR4A1					V
DDIT3					V
MAP3K12					V
GADD45B					V						V
FOS					V				V		V
PGF					V				V		V
DUSP10						V				V		V
PPM1B						V				V		V
BRAF						V				V
RAPGEF2						V
RASA2						V		V		V
NRAS						V				V		V
MET						V		V		V
HSPB1						V				V		V
TGFBR1						V				V		V
IL1R1						V				V		V
PAK2						V				V
MECOM						V
HSPA1A						V				V
PPP3CA						V						V
MAP3K8						V				V
CSF1						V						V
KITLG						V
PDGFC						V
VEGFA						V				V		V
CACNB4							V					V
ATF4							V
IL1RAP							V
CACNG2								V
RPS6KA5								V		V
TAB2								V		V
DUSP16									V
FGFR2									V
CACNA1F									V
EFNA3									V
FGF5									V
IGF2									V
CHUK										V
RAP1A										V
SOS2										V
FLT3										V
MAP3K7										V		V
RAC1										V		V
IRAK4										V
+ 04012: ErbB signaling pathway	0.7	0.1	1.3	0.4	0.4	1.5	1	0.9	0.5	1.6	1	0.6
CDKN1A	V							V
PRKCB	V							V
AKT2	V		V							V		V
AREG		V					V		V
TGFA			V		V		V		V			V
NRG2			V		V		V		V			V
PLCG2			V
EREG			V		V		V		V		V
MYC			V				V
PAK6				V		V				V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
ERBB3					V						V
SHC3					V				V		V
RPS6KB1						V				V
PAK2						V				V
NCK2						V				V		V
SHC2						V
CAMK2B						V		V		V
NRG1						V			V
PIK3CA						V				V
BRAF						V				V
NRAS						V				V		V
GAB1										V
SOS2										V
+ 04014: Ras signaling pathway	1.1	0.3	0.4	1.3	0.6	1.4	0.1	1	0.5	1.5	0.5	0.4
AKT2	V		V							V		V
FGF1	V				V
IGF1	V		V		V
NTF3	V			V		V		V		V
NGFR	V					V				V		V
PRKCB	V							V
RELA	V		V		V
PLA2G4A	V		V		V		V		V
GNGT2	V							V		V
BDNF		V		V		V
VEGFB		V
CSF1R		V				V						V
PLAAT3		V					V
PLA2G5		V				V
TGFA			V		V		V		V			V
PDGFD			V		V		V		V
RASGRF2			V
HTR7			V		V
PLCG2			V
SOS1				V		V				V
AKT3				V		V		V		V	V
ANGPT2				V							V
NGF				V		V				V
RASA1				V		V		V		V
RASAL2				V				V
NF1				V							V
PAK6				V		V				V		V
PRKACB				V		V		V		V		V
SHOC2				V		V				V
SHC3					V				V		V
PGF					V				V		V
KDR					V				V
GAB2					V				V
PLA2G4C					V				V		V
RAPGEF5					V				V
GNB3					V				V		V
GNG5					V
NRAS						V				V		V
PIK3CA						V				V
SHC2						V
CSF1						V						V
KITLG						V
PDGFC						V
VEGFA						V				V		V
MET						V		V		V
TIAM1						V				V		V
PLD1						V				V
RASA2						V		V		V
AFDN						V
GNG10						V						V
GNB4						V
PAK2						V				V
TBK1						V				V
RIN1							V		V
RASSF5							V
SYNGAP1								V
EFNA3									V
FGF5									V
IGF2									V
FGFR2									V
PLCE1									V
SOS2										V
FLT3										V
GAB1										V
RAC1										V		V
RALB										V
CHUK										V
RAP1A										V
ARF6										V
GNB1										V		V
GNG4										V
RASA4												V
+ 04015: Rap1 signaling pathway	0.8	0.4	0.5	0.2	0.8	1.4	0.4	0.5	1.1	1.1	1.1	0.9
FGF1	V				V
IGF1	V		V		V
NGFR	V					V				V		V
LPAR5	V
PRKD1	V		V		V			V		V
AKT2	V		V							V		V
PRKCB	V							V
VEGFB		V
CSF1R		V				V						V
MAP2K6		V					V
EVL		V			V		V		V
PARD6B		V		V		V				V		V
PDGFD			V		V		V		V
RAPGEF3			V		V				V		V
ADORA2B			V
PLCB1			V				V					V
ID1			V		V		V		V
PARD6G			V				V					V
ANGPT2				V							V
NGF				V		V				V
ADORA2A				V		V		V		V		V
RAPGEF6				V		V		V	V	V
AKT3				V		V		V		V	V
APBB1IP					V				V		V
PGF					V				V		V
KDR					V				V
PFN2					V				V		V
LPAR1					V				V		V
RAPGEF5					V				V
SKAP1					V						V
PARD6A					V		V		V
CSF1						V						V
KITLG						V
PDGFC						V
VEGFA						V				V		V
MET						V		V		V
CDH1						V				V		V
AFDN						V
BRAF						V				V
F2R						V				V		V
FPR1						V
MAGI3						V				V
MAGI1						V
RAPGEF2						V
TIAM1						V				V		V
KRIT1						V		V		V		V
PIK3CA						V				V
NRAS						V				V		V
THBS1						V				V		V
PRKCI						V
RASSF5							V
EFNA3									V
FGF5									V
FGFR2									V
ITGAL									V
ADCY1									V
PLCE1									V
RAP1A										V
RAC1										V		V
RALB										V
VAV2										V
ADCY5										V
GNAI3										V
TLN2											V
+ 04310: Wnt signaling pathway	0.2	0.1	0.3	0.3	0	0.3	0.6	0.9	0.5	0.3	0.3	0.8
PRKCB	V							V
WNT11	V			V				V		V
RSPO4	V									V
TCF7		V					V		V
LRP5		V					V
PLCB1			V				V					V
CCND2			V		V		V		V		V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
BAMBI			V
ROCK2				V		V				V		V
PRICKLE1				V
PRKACB				V		V		V		V		V
ROR1				V		V				V		V
FZD4					V				V		V
WNT5B					V				V		V
FRAT1					V				V
SMAD3						V
PPP3CA						V						V
CAMK2B						V		V		V
FZD6						V				V
FZD7						V		V		V
DAAM1						V				V		V
TBL1X						V
TBL1XR1						V				V		V
SFRP1						V
SOST						V
RNF43						V				V		V
PRICKLE3								V
CCN4								V
APC2									V
FRAT2									V
DKK2									V
LRP6									V
WNT10B									V
RAC1										V		V
MAP3K7										V		V
WNT2										V
PRICKLE2												V
+ 04330: Notch signaling pathway	0	0.3	0	0.6	0	0.4	0.5	0	0.2	0.1	0	0.5
LFNG		V				V	V					V
RBPJ				V		V
MAML2				V
JAG1					V				V
CIR1						V				V
KAT2B						V				V
APH1B							V
MAML3									V
NOTCH2										V		V
NUMBL												V
+ 04340: Hedgehog signaling pathway	0.3	0	0.5	1.1	0.5	1	0.1	1.7	0.2	0.6	0.3	0.2
DHH	V							V
KIF7			V		V
CCND2			V		V		V		V		V
PRKACB				V		V		V		V		V
KIF3A				V		V
SPOPL				V		V				V		V
GLI3					V
CSNK1G3						V				V
GLI2						V		V		V
CDON						V
SMURF1								V
HHIP									V
GRK3										V
+ 04350: TGF-beta signaling pathway	2.3	1.1	4	1.4	2.3	2	2.6	2.3	2.3	1.8	2.1	0.7
ID2	V		V		V		V		V
INHBA	V				V			V	V		V
INHBB	V							V		V
TNF	V							V		V
MICOS10-NBL1	V		V							V
NBL1	V		V							V
CHRD	V		V		V
PITX2		V	V			V	V					V
FST		V							V		V
AMHR2		V							V
SMAD9		V	V				V		V
MYC			V				V
ID1			V		V		V		V
ID3			V		V		V		V
BMP2			V		V				V		V
SMAD1			V		V		V		V
BAMBI			V
TGIF2			V
NEO1			V		V		V		V
ROCK1				V		V
ZFYVE16				V		V				V
TGFB2				V		V				V
BMPR2				V		V		V		V		V
BMP4				V		V		V		V
GDF5				V		V		V		V
LTBP1					V		V		V		V
BMPR1B					V				V
RGMB					V				V		V
HAMP					V
THBS1						V				V		V
ACVR2A						V				V		V
SMAD2						V				V		V
SMAD3						V
E2F5						V						V
RPS6KB1						V				V
TGFBR1						V				V		V
SMAD5						V				V
SMAD6							V
RBL1								V
SMURF1								V
AMH											V
FBN1											V
+ 04390: Hippo signaling pathway	0.7	0.3	1.5	2.7	1.5	1.3	2.1	2	2.2	1.4	1.9	0.2
LLGL2	V
TEAD1	V			V		V		V		V
WNT11	V			V				V		V
ID2	V		V		V		V		V
FGF1	V				V
AREG		V					V		V
PARD6B		V		V		V				V		V
TCF7		V					V		V
CCN2			V		V		V		V
PARD6G			V				V					V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
MYC			V				V
CCND2			V		V		V		V		V
BMP2			V		V				V		V
SMAD1			V		V		V		V
ID1			V		V		V		V
FRMD6				V				V
STK3				V		V				V
PPP1CB				V		V				V
MOB1B				V		V				V
MPP5				V		V		V
DLG1				V		V		V		V
TGFB2				V		V				V
BMP4				V		V		V		V
GDF5				V		V		V		V
BMPR2				V		V		V		V		V
TEAD4					V				V		V
PARD6A					V		V		V
WNT5B					V				V		V
FZD4					V				V		V
BMPR1B					V				V
PPP2R2C					V				V		V
CDH1						V				V		V
PRKCI						V
SMAD2						V				V		V
SMAD3						V
TGFBR1						V				V		V
FZD6						V				V
FZD7						V		V		V
GLI2						V		V		V
WNT10B									V
APC2									V
AFP									V		V
TEAD3										V
SERPINE1										V
WNT2										V
AMH											V
WWTR1												V
+ 04392: Hippo signaling pathway - multiple species	1.2	0.6	0.3	2.8	0.2	1	0.3	1.7	0.1	0.9	1.2	0.5
TEAD1	V			V		V		V		V
DCHS2	V							V			V
FAT4		V		V		V
RASSF2			V				V					V
FRMD6				V				V
STK3				V		V				V
MOB1B				V		V				V
TEAD4					V				V		V
TEAD3										V
WWTR1												V
+ 04370: VEGF signaling pathway	1.6	0	1.5	0.1	1	1.2	0.3	0.5	0.8	1.1	1.5	1.2
SPHK1	V		V		V				V		V
PLA2G4A	V		V		V		V		V
AKT2	V		V							V		V
PRKCB	V							V
PLCG2			V
PTGS2			V		V		V		V		V
AKT3				V		V		V		V	V
KDR					V				V
PLA2G4C					V				V		V
HSPB1						V				V		V
PPP3CA						V						V
PIK3CA						V				V
SHC2						V
VEGFA						V				V		V
NRAS						V				V		V
NOS3						V				V
RAC1										V		V
+ 04371: Apelin signaling pathway	0.8	0	0.8	0.5	0.4	1.5	0.6	0.9	0.4	2.2	0.4	1.7
SPHK1	V		V		V				V		V
GNGT2	V							V		V
AKT2	V		V							V		V
NOS1	V							V		V
EGR1	V		V		V		V		V		V
PDE3B		V					V		V
PIK3CG			V		V		V		V
PLCB1			V				V					V
CCN2			V		V		V		V
MEF2C			V		V				V
PRKAA2				V		V				V		V
AKT3				V		V		V		V	V
MYLK				V		V		V		V		V
PRKACB				V		V		V		V		V
PLAT				V		V
GNB3					V				V		V
GNG5					V
JAG1					V				V
PRKAA1						V		V		V
GNG10						V						V
GNB4						V
RPS6KB1						V				V
NRAS						V				V		V
TGFBR1						V				V		V
MYLK4						V				V
NOS3						V				V
MEF2A						V
GNA13						V				V		V
SMAD2						V				V		V
SMAD3						V
CDH1						V				V		V
PRKCE							V					V
ADCY1									V
SERPINE1										V
GNAI3										V
GNB1										V		V
GNG4										V
ITPR3										V
ADCY5										V
MEF2D												V
+ 04064: NF-kappa B signaling pathway	4.1	0.3	2.5	0.9	2.2	1.8	1.4	2.2	1.3	3.2	1.2	1.2
TNF	V							V		V
TNFSF14	V									V
MAP3K14	V
NFKB2	V									V
RELA	V		V		V
PRKCB	V							V
TNFAIP3	V		V		V				V		V
TRAF1	V		V		V
DDX58	V
CCL4L1	V					V		V		V
CCL4L2	V					V		V		V
CCL4	V					V		V		V
CD14		V		V		V
LTB		V		V		V				V		V
IL1B			V		V		V		V
CXCL8			V
TNFRSF11A			V		V		V		V
BCL2A1			V		V		V		V		V
PLCG2			V
PTGS2			V		V		V		V		V
CXCL2			V		V		V		V
MALT1				V		V
TAB3				V		V				V
LTA				V		V		V		V
LTBR					V		V		V
TLR4					V				V
GADD45B					V						V
ERC1					V				V		V
RIPK1						V
IL1R1						V				V		V
CD40						V				V		V
ATM						V
CFLAR						V				V
XIAP						V				V
ICAM1						V				V
CARD11							V					V
CXCL12								V		V
TAB2								V		V
CD40LG									V
IRAK4										V
CHUK										V
MAP3K7										V		V
BCL10										V		V
CCL13										V		V
BIRC3												V
NFKBIA												V
+ 04668: TNF signaling pathway	3.1	0.2	4.8	0.8	3.4	2	3.2	2	1.9	3.5	1.4	2.9
TNF	V							V		V
RELA	V		V		V
CREB5	V		V							V
CASP8	V		V							V		V
CCL5	V							V		V		V
TNFAIP3	V		V		V				V		V
TRAF1	V		V		V
AKT2	V		V							V		V
MAP3K14	V
IRF1	V									V
MAP2K6		V					V
BCL3		V				V
CREB3L3			V				V					V
CCL20			V		V		V		V
CXCL1			V		V		V		V
CXCL2			V		V		V		V
IL18R1			V				V
IL1B			V		V		V		V
JUNB			V		V
MMP3			V		V		V		V		V
MMP9			V				V					V
PTGS2			V		V		V		V		V
MLKL			V		V				V
DAB2IP			V									V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
LTA				V		V		V		V
AKT3				V		V		V		V	V
TAB3				V		V				V
CEBPB					V
FOS					V				V		V
CXCL3					V		V		V
JAG1					V				V
LIF					V
EDN1					V				V		V
RIPK1						V
MAP3K8						V				V
CREB1						V				V
CREB3L1						V				V
CCL2						V				V		V
CSF1						V						V
IL15						V
ICAM1						V				V
TNFRSF1B						V				V		V
PIK3CA						V				V
CFLAR						V				V
ATF4							V
SOCS3							V		V
RPS6KA5								V		V
TAB2								V		V
MAP3K7										V		V
CHUK										V
CASP10										V
BIRC3												V
NFKBIA												V
CX3CL1												V
IL6												V
+ 04066: HIF-1 signaling pathway	1.3	0	0.7	0.3	0.4	0.7	0.1	1	0.3	0.4	0.4	0.4
IGF1	V		V		V
AKT2	V		V							V		V
PRKCB	V							V
RELA	V		V		V
CDKN1A	V							V
PLCG2			V
IL6R			V		V		V		V
HIF1A				V		V		V		V
AKT3				V		V		V		V	V
ANGPT2				V							V
EDN1					V				V		V
LTBR					V		V		V
TLR4					V				V
CUL2						V
VEGFA						V				V		V
EGLN1						V
SLC2A1						V						V
PIK3CA						V				V
PDK1						V				V		V
CAMK2B						V		V		V
NOS3						V				V
RPS6KB1						V				V
ENO3									V
EIF4E									V
SERPINE1										V
EGLN3												V
IL6												V
+ 04068: FoxO signaling pathway	1.6	0.2	1.2	1.1	0.5	1.8	0.4	0.6	0	1.9	1.8	0.8
AKT2	V		V							V		V
IRS2	V				V			V			V
SKP2	V		V							V		V
IGF1	V		V		V
CDKN1A	V							V
SOD2	V									V
SGK1	V		V		V
IL7R		V			V		V		V		V
FOXG1		V							V
G6PC3			V			V	V			V		V
CCND2			V		V		V		V		V
HOMER2			V		V		V		V		V
PRMT1			V
PRKAA2				V		V				V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
PTEN				V		V
TNFSF10				V		V		V		V		V
RAG2				V							V
TGFB2				V		V				V
GADD45B					V						V
S1PR1					V				V		V
PRKAA1						V		V		V
NRAS						V				V		V
BRAF						V				V
PCK2						V
PIK3CA						V				V
IRS1						V
PLK4						V				V
BCL2L11						V				V		V
ATM						V
TGFBR1						V				V		V
SMAD2						V				V		V
SMAD3						V
HOMER1							V
CHUK										V
SOS2										V
SETD7										V
IL6												V
+ 04020: Calcium signaling pathway	1.2	0.3	0.7	1.2	0.9	0.6	0.3	2.6	0.2	0.7	0.5	0.6
NOS1	V							V		V
PRKCB	V							V
SPHK1	V		V		V				V		V
CHRM1	V							V		V
BDKRB2	V									V
CXCR4	V				V			V			V
CACNA1H	V
CACNA1G	V							V
P2RX6		V		V		V				V		V
EDNRA		V		V		V
BDKRB1		V			V				V		V
ASPH		V		V		V	V	V	V	V
CD38			V		V
P2RX5			V		V				V
PLCG2			V
PLCB1			V				V					V
SLC25A5			V									V
ADORA2B			V
ADRB1			V		V		V		V
HTR7			V		V
MYLK				V		V		V		V		V
PHKB				V		V		V		V
EDNRB				V		V		V		V		V
OXTR				V		V		V		V
ADORA2A				V		V		V		V		V
PRKACB				V		V		V		V		V
ATP2B1				V		V		V		V
ITPKB					V				V
PDE1C					V				V		V
ERBB3					V						V
PLCD4					V
GRM5					V		V		V		V
LTB4R2					V
TRDN					V
NOS3						V				V
CAMK2B						V		V		V
PPP3CA						V						V
PTK2B						V				V		V
MYLK4						V				V
ORAI2						V						V
ORAI3						V				V		V
F2R						V				V		V
ATP2B4						V				V		V
VDAC2							V
CCKBR							V
SLC25A4							V
ADCY1									V
PLCE1									V
CACNA1F									V
ITPR3										V
TACR3										V
+ 04070: Phosphatidylinositol signaling system	0.1	0.3	0.2	0.1	0.5	0.6	1.1	0.7	0.1	0.7	0.2	0.6
PRKCB	V							V
PI4K2B		V				V						V
PIK3C2A		V		V		V		V		V
PLCB1			V				V					V
PLCG2			V
DGKK			V
PTEN				V		V
IPPK					V
PLCD4					V
DGKA					V
INPP5K					V						V
ITPKB					V				V
MTMR4					V		V		V
PIK3CA						V				V
PIK3C2B						V	V					V
CDS1						V	V					V
MTM1						V		V		V
MTMR6						V		V		V
PPIP5K2						V				V		V
SACM1L						V				V
IMPA2							V
PIP4P2							V					V
PLCE1									V
INPP5F									V
ITPR3										V
SYNJ1										V
SYNJ2										V
IPMK										V
IMPA1										V		V
ITPK1											V
+ 04072: Phospholipase D signaling pathway	0.4	0	1.5	0.1	0.9	0.5	0.3	0	0.8	0.7	1.6	0.1
AKT2	V		V							V		V
LPAR5	V
PLA2G4A	V		V		V		V		V
SPHK1	V		V		V				V		V
DNM3		V		V		V
PLCG2			V
RAPGEF3			V		V				V		V
PLCB1			V				V					V
PIK3CG			V		V		V		V
DGKK			V
PDGFD			V		V		V		V
CXCL8			V
SOS1				V		V				V
AKT3				V		V		V		V	V
SHC3					V				V		V
GAB2					V				V
LPAR1					V				V		V
GRM5					V		V		V		V
PLA2G4C					V				V		V
DGKA					V
NRAS						V				V		V
PIK3CA						V				V
SHC2						V
KITLG						V
F2R						V				V		V
PLD1						V				V
GNA13						V				V		V
PTK2B						V				V		V
PDGFC						V
AGPAT5						V				V
AGPAT3						V				V		V
FYN								V
GRM4									V
ADCY1									V
SOS2										V
GAB1										V
RALB										V
ADCY5										V
ARF6										V
PLPP3											V
+ 04071: Sphingolipid signaling pathway	1.4	0	0.5	1	0.6	0.6	0.3	0.5	0.7	0.9	2	0.8
AKT2	V		V							V		V
PRKCB	V							V
TNF	V							V		V
SPHK1	V		V		V				V		V
RELA	V		V		V
BDKRB2	V									V
CERS6		V					V		V
PLCB1			V				V					V
ASAH2			V				V					V
AKT3				V		V		V		V	V
ROCK1				V		V
ROCK2				V		V				V		V
PTEN				V		V
PPP2R3A				V		V
SGMS2				V		V				V
S1PR1					V				V		V
S1PR2					V
S1PR3					V				V		V
CERS1					V				V		V
PPP2R2C					V				V		V
GAB2					V				V
PIK3CA						V				V
GNA13						V				V		V
NRAS						V				V		V
SGPP1						V
NOS3						V				V
PLD1						V				V
PRKCE							V					V
FYN								V
SPTLC2									V		V
SGPP2									V		V
GNAI3										V
RAC1										V		V
ADORA3										V		V
+ 04024: cAMP signaling pathway	0.7	0.6	0.1	2.3	0	1.7	0.1	2.3	0.1	1.9	0.6	0.2
CHRM1	V							V		V
SSTR1	V							V
AKT2	V		V							V		V
CREB5	V		V							V
PDE10A	V			V		V		V		V
RELA	V		V		V
SST	V							V		V
EDNRA		V		V		V
CNGA1		V		V		V
PDE3B		V					V		V
PDE4D		V					V
BDNF		V		V		V
EDN2		V		V		V
RAPGEF3			V		V				V		V
CREB3L3			V				V					V
ADRB1			V		V		V		V
OXTR				V		V		V		V
PRKACB				V		V		V		V		V
AKT3				V		V		V		V	V
ATP2B1				V		V		V		V
CREB3L2				V		V		V		V		V
ROCK1				V		V
ROCK2				V		V				V		V
ADORA2A				V		V		V		V		V
PPARA				V		V				V
PPP1CB				V		V				V
ATP1A3					V				V		V
GABBR2					V
GLI3					V
FOS					V				V		V
EDN1					V				V		V
ATP1B1						V
HTR1D						V
PIK3CA						V				V
ATP2B4						V				V		V
BRAF						V				V
CREB1						V				V
CREB3L1						V				V
PPP1R12A						V
CAMK2B						V		V		V
AFDN						V
PLD1						V				V
F2R						V				V		V
TIAM1						V				V		V
ATP1B2							V
PTGER2							V
ATP1A4								V			V
CNGB1								V		V
GRIA4								V
CACNA1F									V
HTR1B									V
ADCY1									V
PLCE1									V
HHIP									V
SSTR5										V		V
GNAI3										V
ADCY5										V
RAP1A										V
VAV2										V
RAC1										V		V
AMH											V
NFKBIA												V
+ 04022: cGMP-PKG signaling pathway	0.9	0.4	1.8	1.8	0.6	2	2.4	1.4	0.6	1.8	1	1.8
GUCY1A1	V										V
MRVI1	V		V		V
CREB5	V		V							V
AKT2	V		V							V		V
IRS2	V				V			V			V
BDKRB2	V									V
CNGA1		V		V		V
EDNRA		V		V		V
NPPB		V					V		V
PDE3B		V					V		V
KCNMB4			V			V	V			V		V
RGS2			V		V		V		V
PLCB1			V				V					V
MEF2C			V		V				V
CREB3L3			V				V					V
PIK3CG			V		V		V		V
PDE2A			V		V		V		V		V
SLC25A5			V									V
ADRB1			V		V		V		V
PPP1CB				V		V				V
EDNRB				V		V		V		V		V
ROCK1				V		V
ROCK2				V		V				V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
ATP2B1				V		V		V		V
AKT3				V		V		V		V	V
MYLK				V		V		V		V		V
KCNU1					V				V		V
TRPC6					V
KCNJ8					V				V
ATP1A3					V				V		V
PPP1R12A						V
PPP3CA						V						V
MEF2A						V
CREB1						V				V
CREB3L1						V				V
ATP1B1						V
ATP2B4						V				V		V
GTF2I						V				V		V
NOS3						V				V
MYLK4						V				V
IRS1						V
GNA13						V				V		V
ATF4							V
ATP1B2							V
PRKCE							V					V
SLC25A4							V
VDAC2							V
CNGB1								V		V
ATP1A4								V			V
CACNA1F									V
ADCY1									V
ITPR3										V
ADCY5										V
GNAI3										V
ADORA3										V		V
MEF2D												V
+ 04151: PI3K-Akt signaling pathway	4.6	1.6	2.2	0.8	2.1	2.6	2.8	1.7	1	1.9	1.1	1.5
AKT2	V		V							V		V
NGFR	V					V				V		V
CHRM1	V							V		V
LPAR5	V
RELA	V		V		V
FGF1	V				V
IGF1	V		V		V
NTF3	V			V		V		V		V
CDC37	V		V		V
CDKN1A	V							V
CDK6	V					V		V		V
GNGT2	V							V		V
ITGA10	V							V		V
COL1A1	V							V		V
COL1A2	V							V		V
COL6A2	V					V				V		V
COL6A3	V		V							V		V
LAMA4	V							V		V
LAMC2	V		V		V
RELN	V		V		V		V		V
THBS2	V		V									V
THBS4	V		V		V		V		V
TNXB	V							V
IL2RG	V				V
PRLR	V				V	V
CREB5	V		V							V
SGK1	V		V		V
PIK3AP1	V		V		V		V		V			V
CSF1R		V				V						V
AREG		V					V		V
BDNF		V		V		V
VEGFB		V
DDIT4		V		V		V	V					V
ITGA1		V				V
ITGB4		V				V				V		V
COL4A4		V				V	V
COL4A5		V					V
COL9A2		V				V
COL6A5		V		V			V		V		V
TNC		V	V		V		V		V
LAMA5		V				V	V
IL7R		V			V		V		V		V
MYC			V				V
G6PC3			V			V	V			V		V
EREG			V		V		V		V		V
TGFA			V		V		V		V			V
PDGFD			V		V		V		V
PIK3CG			V		V		V		V
COL4A6			V				V
IL6R			V		V		V		V
IL7			V		V		V		V
CREB3L3			V				V					V
CCND2			V		V		V		V		V
AKT3				V		V		V		V	V
PTEN				V		V
ANGPT2				V							V
NGF				V		V				V
SOS1				V		V				V
PPP2R3A				V		V
PRKAA2				V		V				V		V
ITGB8				V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
MTCP1				V		V
ERBB3					V						V
KDR					V				V
LPAR1					V				V		V
PGF					V				V		V
PPP2R2C					V				V		V
GNB3					V				V		V
GNG5					V
FN1					V				V		V
LAMA2					V				V		V
TLR4					V				V
MYB					V
NR4A1					V
RPS6KB1						V				V
PIK3CA						V				V
IRS1						V
MET						V		V		V
F2R						V				V		V
BCL2L11						V				V		V
PCK2						V
CSF1						V						V
KITLG						V
PDGFC						V
VEGFA						V				V		V
NRAS						V				V		V
NOS3						V				V
PRKAA1						V		V		V
GNG10						V						V
GNB4						V
ITGA6						V		V		V		V
ITGAV						V				V		V
THBS1						V				V		V
TLR2						V				V		V
OSMR						V
CREB1						V				V
CREB3L1						V				V
PKN2						V				V
CCNE2						V				V
MAGI1						V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
ATF4							V
HSP90AA1								V
EIF4E									V
RPTOR									V
FGFR2									V
EFNA3									V
FGF5									V
IGF2									V
COL9A1									V
FLT3										V
CHUK										V
SOS2										V
GNB1										V		V
GNG4										V
COL6A1										V
RAC1										V		V
BRCA1										V
PHLPP1											V
ITGA2												V
ITGA8												V
IL6												V
+ 04152: AMPK signaling pathway	0.7	1.2	0.8	1.6	0.2	1.7	1.1	0.8	0.1	1.3	0.6	0.8
AKT2	V		V							V		V
IRS2	V				V			V			V
IGF1	V		V		V
CREB5	V		V							V
SREBF1		V		V		V
SCD		V		V		V
SCD5		V					V		V
PPARG		V
CCNA1		V					V		V
CPT1A			V		V		V
G6PC3			V			V	V			V		V
CREB3L3			V				V					V
PRKAA2				V		V				V		V
AKT3				V		V		V		V	V
ACACA				V
PPP2R3A				V		V
LEPR				V		V		V		V		V
CREB3L2				V		V		V		V		V
ADIPOR2					V
FBP2					V						V
PPP2R2C					V				V		V
PRKAA1						V		V		V
PIK3CA						V				V
IRS1						V
FBP1						V				V
PCK2						V
RPS6KB1						V				V
STRADB						V						V
CREB1						V				V
CREB3L1						V				V
TBC1D1							V		V
CCNA2							V					V
RPTOR									V
CAB39L										V
RAB2A										V
MAP3K7										V		V
+ 04150: mTOR signaling pathway	1.3	0.5	0.4	1.8	0.3	1.5	0	1	0.8	1.8	0.3	0.5
AKT2	V		V							V		V
PRKCB	V							V
SGK1	V		V		V
TNF	V							V		V
SKP2	V		V							V		V
IGF1	V		V		V
WNT11	V			V				V		V
RPS6KA2		V				V				V		V
DDIT4		V		V		V	V					V
RICTOR		V		V		V		V		V		V
LRP5		V					V
RRAGD			V		V		V		V
ATP6V1B2			V
PTEN				V		V
AKT3				V		V		V		V	V
RPS6KA3				V		V				V		V
PRKAA2				V		V				V		V
SOS1				V		V				V
ATP6V1G3				V
FNIP1				V
RNF152					V				V		V
SESN2					V
MAPKAP1					V				V
WNT5B					V				V		V
FZD4					V				V		V
IRS1						V
PIK3CA						V				V
BRAF						V				V
NRAS						V				V		V
RPS6KB1						V				V
PRKAA1						V		V		V
ULK2						V						V
ATP6V1A						V
FZD6						V				V
FZD7						V		V		V
CLIP1						V				V
STRADB						V						V
EIF4E									V
LAMTOR1									V
FLCN									V
FNIP2									V
RPTOR									V
WNT10B									V
LRP6									V
SOS2										V
CHUK										V
WNT2										V
CAB39L										V
+ 3.3 Signaling molecules and interaction	7.1	2.3	4.1	0.8	4.1	1.5	4.4	5.6	3.4	4.1	1.8	4.3
+ 04080: Neuroactive ligand-receptor interaction	0.4	0.5	0.1	0.4	0.7	0	0.4	0.3	0.6	0	0.8	0.1
PRLR	V				V	V
PTGER4	V				V
SSTR1	V							V
BDKRB2	V									V
BRS3	V							V		V
CHRM1	V							V		V
SST	V							V		V
ADM	V		V			V	V			V		V
PTH2	V
NR3C1		V		V		V				V		V
P2RX6		V		V		V				V		V
SCTR		V				V	V					V
P2RY6		V				V				V		V
NTSR2		V
EDNRA		V		V		V
BDKRB1		V			V				V		V
EDN2		V		V		V
GAL		V	V		V		V		V
PRSS3			V		V		V		V
P2RX5			V		V				V
ADORA2B			V
F2RL2			V		V				V		V
HTR7			V		V
ADRB1			V		V		V		V
CHRNA5			V				V		V
NMU			V				V
UCN2			V				V		V
LEPR				V		V		V		V		V
GRIK2				V		V				V
ADORA2A				V		V		V		V		V
HCRTR1				V		V
OXTR				V		V		V		V
EDNRB				V		V		V		V		V
C5				V		V
GNRH1				V		V
GABBR2					V
GRM5					V		V		V		V
CALCRL					V				V		V
LTB4R2					V
S1PR1					V				V		V
S1PR3					V				V		V
S1PR2					V
LPAR1					V				V		V
P2RY11					V				V
GALR2					V				V		V
EDN1					V				V		V
KISS1					V				V		V
NPW					V				V
CORT					V				V
GLRB						V						V
GRIK4						V				V		V
GABRE						V				V
F2R						V				V		V
OPRL1						V				V		V
FPR1						V
FPR2						V
HTR1D						V
C3						V						V
PTGER2							V
CCKBR							V
C3AR1							V
CHRNA6							V
NMB							V		V
CTSG								V
GRIA4								V
GRID2									V
GRM4									V
PTGDR									V
HTR1B									V
NPB									V
TACR3										V
ADORA3										V		V
SSTR5										V		V
THRB											V
NPFF											V
NPFFR2												V
MC3R												V
CALCB												V
+ 04060: Cytokine-cytokine receptor interaction	4.6	0.6	2.9	0.7	2.7	0.4	3.4	4.4	2.2	2.5	0.5	2.1
IL2RG	V				V
INHBB	V							V		V
INHBA	V				V			V	V		V
TNFRSF9	V							V		V
CD70	V							V		V
TNFSF14	V									V
IFNL1	V		V		V
IL19	V
MPL	V							V
PRLR	V				V	V
IL23A	V		V							V
CXCR4	V				V			V			V
CXCL11	V									V		V
NGFR	V					V				V		V
TNF	V							V		V
CCL4L1	V					V		V		V
CCL4L2	V					V		V		V
CCL4	V					V		V		V
CCL3L3	V		V		V			V		V		V
CCL3L1	V		V		V			V		V		V
CCL3	V		V		V			V		V		V
CCL26	V
CCL5	V							V		V		V
CCR6	V									V
IL1RN	V							V		V
LIFR		V		V		V		V		V		V
AMHR2		V							V
TNFSF18		V
LTB		V		V		V				V		V
IL7R		V			V		V		V		V
IL31RA		V					V		V
CSF1R		V				V						V
GDF3		V					V		V
IL22RA1			V							V		V
IL18R1			V				V
IL18			V		V		V		V		V
IL1B			V		V		V		V
IL1A			V		V
BMP2			V		V				V		V
IFNLR1			V				V					V
IL24			V		V		V
IL15RA			V
IL7			V		V		V		V
IL11RA			V		V
IL6R			V		V		V		V
IL11			V				V					V
CXCL8			V
TNFRSF11A			V		V		V		V
TNFRSF10B			V							V		V
CXCL1			V		V		V		V
CXCL2			V		V		V		V
CCL20			V		V		V		V
BMPR2				V		V		V		V		V
GDF5				V		V		V		V
TGFB2				V		V				V
LTA				V		V		V		V
CXCL16				V				V		V
TNFSF10				V		V		V		V		V
CCR2				V							V
NGF				V		V				V
BMP4				V		V		V		V
LEPR				V		V		V		V		V
BMPR1B					V				V
LTBR					V		V		V
LIF					V
TNFRSF10D					V				V		V
CXCL3					V		V		V
CCR10					V				V
CCL18					V
IL36B					V		V		V
GDF11					V				V
GDF15					V		V		V		V
ACVR2A						V				V		V
CSF2RB						V				V
IL6ST						V
IL1R1						V				V		V
TGFBR1						V				V		V
CD40						V				V		V
IL15						V
OSMR						V
TNFRSF1B						V				V		V
TNFSF15						V
CCL2						V				V		V
CSF1						V						V
IL1RAP							V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
IL12A							V
TNFRSF10C							V					V
IL18RAP								V		V
CXCL12								V		V
IL17C								V
CCL11								V
CD40LG									V
IL20									V
CLCF1									V
XCL2									V
XCL1									V
PF4									V
CXCL9									V
CCR8									V
GDF9									V
IL10RB										V		V
CNTFR										V
IL12B										V
CCL13										V		V
GDF2										V
AMH											V
IL10RA												V
IL6												V
CX3CL1												V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	5.1	0.1	3.5	0.3	3.4	0.6	2.5	4.3	2.7	3.2	0.8	3.8
CCL3L3	V		V		V			V		V		V
CCL3L1	V		V		V			V		V		V
CCL3	V		V		V			V		V		V
CCL5	V							V		V		V
CCL26	V
CCL4L1	V					V		V		V
CCL4L2	V					V		V		V
CCL4	V					V		V		V
CCR6	V									V
CXCL11	V									V		V
CXCR4	V				V			V			V
IL2RG	V				V
IL19	V
TNFSF14	V									V
TNF	V							V		V
CSF1R		V				V						V
CCL20			V		V		V		V
CXCL1			V		V		V		V
CXCL2			V		V		V		V
CXCL8			V
IL6R			V		V		V		V
IL18R1			V				V
IL18			V		V		V		V		V
IL24			V		V		V
IL22RA1			V							V		V
TNFRSF10B			V							V		V
CCR2				V							V
LTA				V		V		V		V
TNFSF10				V		V		V		V		V
CCR10					V				V
CCL18					V
CXCL3					V		V		V
LTBR					V		V		V
TNFRSF10D					V				V		V
CCL2						V				V		V
IL6ST						V
CSF1						V						V
TNFRSF1B						V				V		V
TNFRSF10C							V					V
CCL11								V
CXCL12								V		V
IL18RAP								V		V
CCR8									V
CXCL9									V
PF4									V
XCL1									V
XCL2									V
IL20									V
CCL13										V		V
IL10RB										V		V
CX3CL1												V
IL10RA												V
IL6												V
+ 04512: ECM-receptor interaction	4	3.4	1.7	0.2	1.3	2	2.5	2.1	1.3	2.4	1.4	2.5
LAMA4	V							V		V
LAMC2	V		V		V
COL1A1	V							V		V
COL1A2	V							V		V
COL6A2	V					V				V		V
COL6A3	V		V							V		V
TNXB	V							V
THBS2	V		V									V
THBS4	V		V		V		V		V
ITGA10	V							V		V
RELN	V		V		V		V		V
LAMA5		V				V	V
COL4A4		V				V	V
COL4A5		V					V
COL9A2		V				V
COL6A5		V		V			V		V		V
TNC		V	V		V		V		V
ITGB4		V				V				V		V
ITGA1		V				V
FRAS1		V			V		V		V		V
COL4A6			V				V
ITGB8				V		V		V		V
LAMA2					V				V		V
FN1					V				V		V
FREM1					V				V		V
GP1BB						V				V		V
THBS1						V				V		V
ITGA6						V		V		V		V
ITGAV						V				V		V
HMMR						V				V
CD47						V
AGRN						V						V
COL9A1									V
COL6A1										V
CD44										V
FREM2										V		V
ITGA8												V
ITGA2												V
+ 4. Cellular Processes	3.2	2.7	4.4	3.7	1.9	6.1	4.3	4.1	1.5	6.7	1.8	4.5
+ 4.1 Transport and catabolism	0.6	2	1.9	2.5	0.8	3.4	2	1.6	0.3	3.3	0.4	2.3
+ 04144: Endocytosis	0.1	0.7	0	1.6	0	2.9	0	0.3	0	2.8	0	1.2
STAMBP	V
HSPA1B	V							V		V
CXCR4	V				V			V			V
IL2RG	V				V
DNM3		V		V		V
PARD6B		V		V		V				V		V
GRK1		V					V		V
EEA1		V		V		V				V		V
FOLR1		V		V		V
FOLR2		V		V		V
KIF5B		V		V		V		V		V
CHMP4C			V									V
PARD6G			V				V					V
RAB11FIP3			V
USP8				V		V		V		V
DNAJC6				V		V				V
RAB11FIP2				V		V				V
ASAP1				V		V				V		V
ZFYVE16				V		V				V
CAV2				V		V				V		V
WASHC4				V		V				V		V
CAPZA2				V		V				V
PARD6A					V		V		V
FOLR3					V				V		V
STAM2						V				V		V
MVB12B						V
VPS37A						V				V		V
HSPA1A						V				V
PDCD6IP						V				V
PRKCI						V
EPS15						V		V		V
SH3GLB1						V				V
PLD1						V				V
ARFGEF2						V				V		V
PSD3						V				V		V
ACAP2						V				V		V
ASAP3						V				V		V
ASAP2						V				V
HLA-F						V				V		V
TGFBR1						V				V		V
SMAD2						V				V		V
SMAD3						V
CAV1						V
SPART						V				V
VPS26A						V				V
RAB22A						V				V
BIN1						V				V		V
WIPF1						V				V		V
VPS26B							V		V
RAB11FIP4							V		V
SMURF1								V
DAB2								V			V
CHMP6									V
EPN3									V
FGFR2									V
ARAP2									V		V
ARAP1									V
SNX32									V
VPS36										V
ARF6										V
GRK3										V
ACAP3										V
HLA-B										V
HLA-C										V		V
SNX3										V
SH3KBP1												V
+ 04145: Phagosome	1	3.3	4.3	0.9	0.8	2	4.6	0.7	0.2	1.4	0	3.7
NCF2	V		V		V			V
MPO	V							V
MARCO	V							V		V
NOS1	V							V		V
THBS2	V		V									V
THBS4	V		V		V		V		V
MRC2		V					V		V
EEA1		V		V		V				V		V
NCF1		V					V
CD14		V		V		V
COLEC12		V		V		V		V		V		V
HLA-DMA		V		V		V	V					V
HLA-DMB		V				V	V					V
HLA-DPA1		V	V			V	V			V		V
HLA-DRA		V	V			V	V					V
HLA-DRB1		V	V			V	V					V
HLA-DRB3		V	V			V	V					V
HLA-DRB4		V	V			V	V					V
FCGR2A			V				V			V		V
FCGR2C			V				V			V		V
DYNC1I1			V		V		V		V
TUBA3E			V				V
TUBA3D			V				V
TUBA3C			V				V
TUBA4A			V		V		V		V
TUBA1A			V				V
ATP6V1B2			V
ATP6V0E1			V		V		V		V		V
OLR1			V
CORO1A			V		V
ATP6V1G3				V
LAMP2				V		V		V		V
TAP2				V		V
TUBB1					V
M6PR					V				V
ATP6V0E2					V				V
ATP6V0A1					V
TLR4					V				V
ITGAV						V				V		V
PLA2R1						V
DYNC1I2						V				V
TUBB						V				V		V
ATP6V0A4						V
ATP6V1A						V
TLR2						V				V		V
C3						V						V
THBS1						V				V		V
HLA-F						V				V		V
TUBB4A							V
HLA-DOA							V					V
RAC1										V		V
TUBAL3										V		V
STX7										V
TAP1										V
HLA-B										V
HLA-C										V		V
ITGA2												V
+ 04142: Lysosome	0	0.8	0	0.4	0	0.1	0	0.1	0.2	0.3	0.6	0.3
CTSV		V					V		V			V
CTSO		V				V				V		V
NAGLU		V
IDUA		V
CTSC			V		V		V		V		V
GGA1			V
GALC				V							V
ARSA				V					V		V
LAMP2				V		V		V		V
AP4E1				V		V				V
ATP6V0A1					V
CD68					V				V
M6PR					V				V
ATP6V0A4						V
FUCA1						V				V		V
LAPTM5						V				V		V
CD164						V				V
MFSD8						V				V		V
LITAF						V				V		V
CTSG								V
ABCB9									V
AP1M2									V
SLC17A5										V
AP1S2										V
AP4S1										V		V
ARSG											V
+ 04146: Peroxisome	0.1	0.4	0.4	0.5	0.5	1.3	0.4	0.6	0.2	2	0	0.4
SOD2	V									V
PECR		V		V		V				V		V
IDH2		V				V
ACOX2			V		V		V		V
SLC27A2			V		V		V		V
MPV17L2			V		V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
PEX5					V				V
MPV17					V
ABCD3						V				V
AGPS						V				V
SCP2						V				V
CROT						V				V		V
NUDT12						V				V		V
FAR1						V				V
EPHX2						V				V
HAO1							V		V
ACSL6								V		V
DDO										V
NUDT19										V		V
PEX10												V
+ 04140: Autophagy - animal	0.1	0	0	1.2	0.2	1.9	0.1	1.3	0	1.3	0.3	0.3
IRS2	V				V			V			V
AKT2	V		V							V		V
DDIT4		V		V		V	V					V
RRAGD			V		V		V		V
PTEN				V		V
AKT3				V		V		V		V	V
HIF1A				V		V		V		V
PRKAA2				V		V				V		V
PRKACB				V		V		V		V		V
LAMP2				V		V		V		V
IGBP1					V
WIPI1					V
MTMR4					V		V		V
DAPK3					V				V		V
IRS1						V
PIK3CA						V				V
NRAS						V				V		V
RPS6KB1						V				V
ULK2						V						V
RB1CC1						V
PRKAA1						V		V		V
STX17						V				V
SH3GLB1						V				V
HMGB1						V				V
DAPK2						V		V		V
CFLAR						V				V
RPTOR									V
ATG16L2									V
PRKCD										V
MAP3K7										V		V
+ 04136: Autophagy - other	0	0	0	0	0.5	0	0	0	0.1	0	0	0.1
IGBP1					V
WIPI1					V
ULK2						V						V
RPTOR									V
+ 04137: Mitophagy - animal	0.2	0	0.3	2	0.1	0.7	0.1	1.3	0	0.9	0.1	0.1
RELA	V		V		V
SQSTM1			V		V
PINK1				V
USP8				V		V		V		V
PRKN				V				V
BNIP3L				V		V				V
TAX1BP1				V		V		V		V
HIF1A				V		V		V		V
TBK1						V				V
TBC1D15						V				V
NRAS						V				V		V
ATF4							V
TFEB										V		V
MITF											V
+ 4.2 Cell growth and death	2.6	0.5	3.4	1.4	1.1	3	2.6	2	0.4	4	1.4	2.8
+ 04110: Cell cycle	0.6	0.2	0.4	0.3	0	1.8	0.7	1.1	0	1.4	0.1	0.7
CDC27	V		V							V		V
CDKN1A	V							V
SKP2	V		V							V		V
CDK6	V					V		V		V
CCNA1		V					V		V
SMC3		V		V		V				V
CDC25A			V
CCND2			V		V		V		V		V
MYC			V				V
ATR				V		V				V
TGFB2				V		V				V
STAG2				V		V				V
GADD45B					V						V
MAD1L1					V				V
ORC3						V		V		V
ORC4						V				V		V
CDK1						V				V		V
ATM						V
MAD2L1						V						V
ESPL1						V				V		V
RB1						V				V
SMAD2						V				V		V
SMAD3						V
CCNE2						V				V
TTK						V		V		V
STAG1						V		V		V
E2F5						V						V
ANAPC11							V		V
PTTG2							V
CCNA2							V					V
RBL1								V
WEE2										V
+ 04114: Oocyte meiosis	0.1	0.2	1	0.6	0	0.9	0.1	0.2	0	1.4	0	1.2
CDC27	V		V							V		V
IGF1	V		V		V
RPS6KA2		V				V				V		V
SMC3		V		V		V				V
AURKA			V				V					V
SPDYE1			V
SPDYE3			V
SPDYE5			V
SPDYE6			V
RPS6KA3				V		V				V		V
PRKACB				V		V		V		V		V
PPP1CB				V		V				V
SLK				V		V				V
MAD1L1					V				V
CDK1						V				V		V
MAD2L1						V						V
CCNE2						V				V
CAMK2B						V		V		V
PPP3CA						V						V
CPEB4						V				V
ESPL1						V				V		V
SGO1						V				V		V
ANAPC11							V		V
PTTG2							V
SPDYA								V		V
CPEB1									V
ADCY1									V
FBXO5										V
ITPR3										V
ADCY5										V
PGR												V
+ 04210: Apoptosis	1.2	0.4	2.6	0.1	0.6	0.4	1.4	0.2	0.3	1.6	0.7	1.2
RELA	V		V		V
CASP8	V		V							V		V
AKT2	V		V							V		V
MAP3K14	V
TNF	V							V		V
TRAF1	V		V		V
PTPN13		V
CTSV		V					V		V			V
CTSO		V				V				V		V
TNFRSF10B			V							V		V
BCL2A1			V		V		V		V		V
DAB2IP			V									V
CTSC			V		V		V		V		V
TUBA3E			V				V
TUBA3D			V				V
TUBA3C			V				V
TUBA4A			V		V		V		V
TUBA1A			V				V
AKT3				V		V		V		V	V
NGF				V		V				V
TNFSF10				V		V		V		V		V
GADD45B					V						V
FOS					V				V		V
DDIT3					V
HRK					V				V
ATM						V
XIAP						V				V
CFLAR						V				V
PIK3CA						V				V
RIPK1						V
CSF2RB						V				V
BCL2L11						V				V		V
NRAS						V				V		V
ATF4							V
ENDOG									V
DIABLO									V
CASP10										V
CHUK										V
PMAIP1										V
ITPR3										V
TUBAL3										V		V
BIRC3												V
NFKBIA												V
+ 04215: Apoptosis - multiple species	1.1	0	0.3	0.4	0	0.8	0	0	0.1	1.2	0	1.4
CASP8	V		V							V		V
NGFR	V					V				V		V
BIRC6				V		V
XIAP						V				V
BCL2L11						V				V		V
DIABLO									V
PMAIP1										V
BIRC3												V
+ 04216: Ferroptosis	0.4	0.4	0	1.3	0.1	0.9	1.6	1.4	0.2	0.8	0.3	0.6
GCLM	V					V				V		V
SLC7A11		V		V		V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
SAT1					V				V		V
PRNP						V				V		V
VDAC2							V
STEAP3							V
FTH1							V					V
SLC39A8							V		V
ACSL6								V		V
+ 04217: Necroptosis	0.6	0.1	2.4	0	0.9	0	2.2	0.4	0.3	0.1	1.1	0.6
TNF	V							V		V
CASP8	V		V							V		V
TNFAIP3	V		V		V				V		V
H2AFX	V		V
PLA2G4A	V		V		V		V		V
TLR3		V				V				V		V
CASP1		V	V		V		V		V		V
MLKL			V		V				V
TNFRSF10B			V							V		V
IL1A			V		V
SLC25A5			V									V
IL1B			V		V		V		V
HIST1H2AJ			V				V
HIST1H2AC			V		V				V		V
CHMP4C			V									V
SQSTM1			V		V
TNFSF10				V		V		V		V		V
GLUL				V				V			V
TLR4					V				V
TYK2					V						V
H2AFJ					V		V		V		V
PLA2G4C					V				V		V
XIAP						V				V
CFLAR						V				V
TRPM7						V
RIPK1						V
HMGB1						V				V
PYCARD						V				V		V
H2AFV						V				V		V
CAMK2B						V		V		V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
SLC25A4							V
FTH1							V					V
HIST2H2AC							V
VDAC2							V
HSP90AA1								V
CHMP6									V
EIF2AK2										V		V
BIRC3												V
+ 04115: p53 signaling pathway	1.4	0	1.6	0.6	1.3	1.9	0.5	0.7	0.3	2.1	1.3	1.2
IGF1	V		V		V
CDKN1A	V							V
CASP8	V		V							V		V
CDK6	V					V		V		V
SERPINB5			V		V		V		V			V
TNFRSF10B			V							V		V
CCND2			V		V		V		V		V
PERP			V
ATR				V		V				V
CCNG1				V		V
PTEN				V		V
IGFBP3					V				V		V
GADD45B					V						V
TP53I3					V				V		V
SESN2					V
ATM						V
CCNE2						V				V
RRM2B						V				V
CD82						V				V		V
THBS1						V				V		V
CDK1						V				V		V
RCHY1						V				V		V
GORAB						V				V
STEAP3							V
ZMAT3								V
SERPINE1										V
PMAIP1										V
+ 04218: Cellular senescence	1.9	0.2	1.1	0.8	0.1	1.7	0.8	1.8	0	2.6	0.5	1
AKT2	V		V							V		V
CDK6	V					V		V		V
CDKN1A	V							V
RELA	V		V		V
KIR2DL1	V							V		V
KIR2DL2	V							V		V
KIR2DL3	V							V		V
KIR2DL4	V							V		V
KIR2DL5A	V							V		V
HIPK3		V
MAP2K6		V					V
CCNA1		V					V		V
MYC			V				V
CCND2			V		V		V		V		V
CDC25A			V
SQSTM1			V		V
IL1A			V		V
CXCL8			V
SLC25A5			V									V
PPP1CB				V		V				V
HIPK2				V		V		V		V
AKT3				V		V		V		V	V
MRE11				V
ATR				V		V				V
TGFB2				V		V				V
PTEN				V		V
GADD45B					V						V
IGFBP3					V				V		V
PIK3CA						V				V
NRAS						V				V		V
CCNE2						V				V
RB1						V				V
E2F5						V						V
LIN9						V				V		V
RBBP4						V
ATM						V
CDK1						V				V		V
PPP3CA						V						V
TRPM7						V
SMAD2						V				V		V
SMAD3						V
TGFBR1						V				V		V
HLA-F						V				V		V
RASSF5							V
CCNA2							V					V
SLC25A4							V
VDAC2							V
RBL1								V
FOXM1									V
RAD9B										V
ZFP36L2										V
ITPR3										V
SERPINE1										V
HLA-B										V
HLA-C										V		V
TRAF3IP2											V
IL6												V
+ 4.3 Cellular community - eukaryotes	2.4	2	3.4	3	1.7	3.6	3.9	3.4	1.9	3.5	1.6	2.4
+ 04510: Focal adhesion	3	2	1.1	1.7	0.4	2.6	1.1	1.9	0.5	3	1	1.5
ITGA10	V							V		V
AKT2	V		V							V		V
PRKCB	V							V
COL1A1	V							V		V
COL1A2	V							V		V
COL6A2	V					V				V		V
COL6A3	V		V							V		V
LAMA4	V							V		V
LAMC2	V		V		V
RELN	V		V		V		V		V
THBS2	V		V									V
THBS4	V		V		V		V		V
TNXB	V							V
IGF1	V		V		V
ITGB4		V				V				V		V
ITGA1		V				V
MYL5		V					V		V
COL4A4		V				V	V
COL4A5		V					V
COL9A2		V				V
COL6A5		V		V			V		V		V
TNC		V	V		V		V		V
LAMA5		V				V	V
VEGFB		V
COL4A6			V				V
CCND2			V		V		V		V		V
PDGFD			V		V		V		V
ITGB8				V		V		V		V
MYLK				V		V		V		V		V
PPP1CB				V		V				V
ROCK1				V		V
ROCK2				V		V				V		V
AKT3				V		V		V		V	V
PTEN				V		V
ARHGAP5				V		V				V		V
CAV2				V		V				V		V
SOS1				V		V				V
PAK6				V		V				V		V
FN1					V				V		V
LAMA2					V				V		V
KDR					V				V
PGF					V				V		V
SHC3					V				V		V
ITGA6						V		V		V		V
ITGAV						V				V		V
MYLK4						V				V
PPP1R12A						V
PIK3CA						V				V
THBS1						V				V		V
CAV1						V
XIAP						V				V
BRAF						V				V
MET						V		V		V
PDGFC						V
VEGFA						V				V		V
SHC2						V
PAK2						V				V
FYN								V
PPP1R12B									V
COL9A1									V
PARVB										V
ARHGAP35										V
COL6A1										V
SOS2										V
RAP1A										V
RAC1										V		V
VAV2										V
TLN2											V
ITGA2												V
ITGA8												V
BIRC3												V
+ 04520: Adherens junction	0.5	0.2	1.6	0.6	0.7	1.6	1.6	1.6	0.5	1.5	0.1	1.6
PTPRB	V							V
SORBS1	V		V									V
TCF7		V					V		V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
SNAI1			V		V
NECTIN1			V		V		V		V
NECTIN4			V				V
FER				V		V		V
PTPRM				V
SSX2IP				V		V				V
WASF3					V		V		V
BAIAP2					V				V
CDH1						V				V		V
SMAD2						V				V		V
SMAD3						V
YES1						V		V		V
TGFBR1						V				V		V
MET						V		V		V
PTPRJ						V				V		V
PTPRF						V
AFDN						V
FYN								V
MAP3K7										V		V
WASF1										V
RAC1										V		V
IQGAP1										V
+ 04530: Tight junction	0.5	0.7	0.9	2.4	0	1.3	2.1	2	0.4	1	0.1	1.3
LLGL2	V
MPP4	V		V		V				V		V
HCLS1	V							V
RAB8B	V							V		V		V
MYL6	V
PARD6B		V		V		V				V		V
SYNPO		V					V		V
MARVELD3		V				V	V					V
MYH2		V					V		V
MYH10		V				V						V
PARD6G			V				V					V
F11R			V
CLDN7			V									V
TUBA3E			V				V
TUBA3D			V				V
TUBA3C			V				V
TUBA4A			V		V		V		V
TUBA1A			V				V
ROCK1				V		V
ROCK2				V		V				V		V
RAPGEF6				V		V		V	V	V
PRKACB				V		V		V		V		V
MPDZ				V		V				V
MAP3K1				V		V		V		V
CLDN11				V		V		V		V		V
CLDN2				V		V		V		V
CLDN9				V				V			V
PRKAA2				V		V				V		V
MPP5				V		V		V
DLG1				V		V		V		V
PARD6A					V		V		V
PPP2R2C					V				V		V
YBX3					V				V
TIAM1						V				V		V
PRKCI						V
MAGI1						V
PRKAA1						V		V		V
AFDN						V
RAPGEF2						V
CGNL1						V				V
OCLN							V		V
CLDN3							V		V
PRKCE							V					V
CLDN16									V
RAC1										V		V
RAP1A										V
TUBAL3										V		V
ACTR3										V
ACTR2										V		V
CD1C										V
+ 04540: Gap junction	0.3	0.4	2.4	0.4	0.9	0.3	3.1	0.2	0.7	0.8	1	0.6
PRKCB	V							V
GUCY1A1	V										V
GJA1		V	V		V		V		V		V
MAP3K2		V		V		V
TUBA3E			V				V
TUBA3D			V				V
TUBA3C			V				V
TUBA4A			V		V		V		V
TUBA1A			V				V
PDGFD			V		V		V		V
ADRB1			V		V		V		V
PLCB1			V				V					V
PRKACB				V		V		V		V		V
SOS1				V		V				V
LPAR1					V				V		V
TUBB1					V
GRM5					V		V		V		V
CDK1						V				V		V
TUBB						V				V		V
NRAS						V				V		V
PDGFC						V
TUBB4A							V
ADCY1									V
GNAI3										V
ADCY5										V
TUBAL3										V		V
SOS2										V
ITPR3										V
+ 04550: Signaling pathways regulating pluripotency of stem cells	1.2	1.3	1.7	1.6	1.8	2.3	0.8	1.8	2.2	1.7	1.4	0.3
WNT11	V			V				V		V
AKT2	V		V							V		V
INHBA	V				V			V	V		V
INHBB	V							V		V
IGF1	V		V		V
ID2	V		V		V		V		V
TCF7		V					V		V
LIFR		V		V		V		V		V		V
SMAD9		V	V				V		V
SMARCAD1		V		V		V
RIF1		V		V		V
PCGF5		V		V		V		V		V		V
KLF4			V		V
SMAD1			V		V		V		V
MYC			V				V
ID1			V		V		V		V
ID3			V		V		V		V
HAND1			V		V				V		V
AKT3				V		V		V		V	V
BMP4				V		V		V		V
BMPR2				V		V		V		V		V
SKIL				V		V
WNT5B					V				V		V
FZD4					V				V		V
LIF					V
BMPR1B					V				V
MEIS1					V				V		V
ONECUT1					V				V		V
FZD6						V				V
FZD7						V		V		V
IL6ST						V
PIK3CA						V				V
ACVR2A						V				V		V
SMAD2						V				V		V
SMAD3						V
POU5F1						V				V
POU5F1B						V				V
NRAS						V				V		V
SMAD5						V				V
JARID2						V				V		V
COMMD3-BMI1						V
BMI1						V
WNT10B									V
APC2									V
NANOG									V
FGFR2									V
WNT2										V
ZFHX3										V
+ 4.5 Cell motility	0.7	0.9	0	0.5	0.1	2.1	0	1.2	0.3	2.6	0.2	1.4
+ 04810: Regulation of actin cytoskeleton	0.7	0.9	0	0.5	0.1	2.1	0	1.2	0.3	2.6	0.2	1.4
ARHGEF4	V	V				V	V	V		V		V
CHRM1	V							V		V
BDKRB2	V									V
ITGA10	V							V		V
FGF1	V				V
CXCR4	V				V			V			V
LPAR5	V
CYFIP2		V	V		V		V		V
MYL5		V					V		V
BDKRB1		V			V				V		V
ITGA1		V				V
ITGB4		V				V				V		V
MYH10		V				V						V
BRK1			V									V
ABI2			V									V
SCIN			V
PDGFD			V		V		V		V
DIAPH2				V		V		V		V		V
PPP1CB				V		V				V
MYLK				V		V		V		V		V
ROCK1				V		V
ROCK2				V		V				V		V
PAK6				V		V				V		V
ITGB8				V		V		V		V
SOS1				V		V				V
PFN2					V				V		V
BAIAP2					V				V
FN1					V				V		V
LPAR1					V				V		V
NCKAP1						V				V
SSH3						V
CFL1						V				V		V
CFL2						V		V		V
LIMK1						V
PPP1R12A						V
MYLK4						V				V
DIAPH3						V				V
PAK2						V				V
TIAM1						V				V		V
BRAF						V				V
PIK3CA						V				V
ITGA6						V		V		V		V
ITGAV						V				V		V
NRAS						V				V		V
GNA13						V				V		V
PDGFC						V
F2R						V				V		V
CXCL12								V		V
APC2									V
PPP1R12B									V
ITGAL									V
FGFR2									V
FGF5									V
WASF1										V
GSN										V
RAC1										V		V
IQGAP1										V
ARHGAP35										V
VAV2										V
SOS2										V
ITGA2												V
ITGA8												V
+ 5. Organismal Systems	8.3	4.1	7.7	5.3	5.1	6.6	8.1	9.6	3.9	9	6.3	6.4
+ 5.1 Immune system	7.9	4.8	7.4	2.2	3.8	4.5	8.1	5.7	2.1	7.9	2.6	7.3
+ 04640: Hematopoietic cell lineage	0.1	4.4	4.2	0.1	1.7	2.2	4.9	0.2	1.1	0.2	0.1	3.9
TNF	V							V		V
ITGA1		V				V
CD14		V		V		V
CSF1R		V				V						V
CD3D		V	V		V		V		V			V
IL7R		V			V		V		V		V
HLA-DMA		V		V		V	V					V
HLA-DMB		V				V	V					V
HLA-DPA1		V	V			V	V			V		V
HLA-DRA		V	V			V	V					V
HLA-DRB1		V	V			V	V					V
HLA-DRB3		V	V			V	V					V
HLA-DRB4		V	V			V	V					V
IL11RA			V		V
IL6R			V		V		V		V
CD33			V				V					V
CD24			V		V		V		V
CD38			V		V
IL11			V				V					V
IL1A			V		V
IL1B			V		V		V		V
IL7			V		V		V		V
CD22					V		V		V
ITGA6						V		V		V		V
GP1BB						V				V		V
IL1R1						V				V		V
DNTT						V
CSF1						V						V
KITLG						V
HLA-DOA							V					V
CD9									V
GYPA									V
CD44										V
CD1C										V
FLT3										V
ITGA2												V
IL6												V
+ 04610: Complement and coagulation cascades	0.8	0.9	1.1	2.1	1.1	2.8	0.7	0.1	0.4	1	1.1	1.7
SERPINB2	V		V		V				V		V
BDKRB2	V									V
C4BPA	V									V
BDKRB1		V			V				V		V
PROS1		V
CFB		V		V		V
SERPIND1			V		V		V		V			V
C1S			V				V
CFH			V		V		V		V
F2RL2			V		V				V		V
TFPI				V		V				V
PLAT				V		V
C5				V		V
C4BPB				V		V		V		V
C2				V		V				V		V
CLU				V		V				V		V
C1QB					V						V
PLAUR					V
F2R						V				V		V
C3						V						V
CD46						V						V
SERPINA1						V				V		V
C4A						V
C4B						V
C4B_2						V
F3						V						V
CFD						V				V		V
C3AR1							V
SERPINE1										V
+ 04611: Platelet activation	1	0	0.7	0.9	0	1.3	0.2	1.1	0.1	2.4	0.9	1.5
AKT2	V		V							V		V
GUCY1A1	V										V
PLA2G4A	V		V		V		V		V
COL1A1	V							V		V
COL1A2	V							V		V
PLCB1			V				V					V
PLCG2			V
PIK3CG			V		V		V		V
FCGR2A			V				V			V		V
AKT3				V		V		V		V	V
ROCK1				V		V
ROCK2				V		V				V		V
PPP1CB				V		V				V
MYLK				V		V		V		V		V
PRKACB				V		V		V		V		V
APBB1IP					V				V		V
PLA2G4C					V				V		V
F2R						V				V		V
PIK3CA						V				V
NOS3						V				V
GNA13						V				V		V
PPP1R12A						V
MYLK4						V				V
PTGS1						V				V		V
TBXAS1						V						V
GP1BB						V				V		V
PRKCI						V
FYN								V
ADCY1									V
ITPR3										V
RAP1A										V
GNAI3										V
ADCY5										V
ARHGAP35										V
TLN2											V
ITGA2												V
+ 04620: Toll-like receptor signaling pathway	3.9	0.6	1.6	0.1	0.6	1.1	1.3	2.8	0.1	4	0.4	2.5
CXCL11	V									V		V
CCL5	V							V		V		V
AKT2	V		V							V		V
TNF	V							V		V
CASP8	V		V							V		V
CCL3L3	V		V		V			V		V		V
CCL3L1	V		V		V			V		V		V
CCL3	V		V		V			V		V		V
RELA	V		V		V
CCL4L1	V					V		V		V
CCL4L2	V					V		V		V
CCL4	V					V		V		V
TLR3		V				V				V		V
CD14		V		V		V
MAP2K6		V					V
CXCL8			V
IL1B			V		V		V		V
AKT3				V		V		V		V	V
TLR4					V				V
FOS					V				V		V
MAP3K8						V				V
RIPK1						V
CD40						V				V		V
TBK1						V				V
TLR2						V				V		V
TLR5						V				V
PIK3CA						V				V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
IL12A							V
TAB2								V		V
CXCL9									V
TLR7									V
CHUK										V
IRAK4										V
MAP3K7										V		V
RAC1										V		V
IL12B										V
TOLLIP											V
IL6												V
NFKBIA												V
+ 04621: NOD-like receptor signaling pathway	1.4	0.2	3.3	0.1	2.3	0.6	3.3	0.3	1	2.1	0.9	1.2
RELA	V		V		V
GBP5	V		V							V		V
TNFAIP3	V		V		V				V		V
CASP8	V		V							V		V
OAS1	V		V
OAS2	V		V		V
TNF	V							V		V
CCL5	V							V		V		V
CASP1		V	V		V		V		V		V
GBP2		V				V	V			V		V
NLRX1		V
IL1B			V		V		V		V
IL18			V		V		V		V		V
PLCB1			V				V					V
CASP4			V		V		V		V		V
CXCL8			V
CXCL1			V		V		V		V
CXCL2			V		V		V		V
DEFB4B			V		V		V		V
DEFB4A			V		V		V		V
DEFB103A			V		V		V		V
DEFB103B			V		V		V		V
TAB3				V		V				V
ERBIN				V		V				V
NEK7				V		V		V		V		V
BRCC3				V		V				V
TRPV2					V				V		V
TYK2					V						V
TLR4					V				V
NFKBIB					V				V		V
TMEM173					V
CXCL3					V		V		V
PYCARD						V				V		V
NAIP						V
AIM2						V				V		V
TRPM7						V
TBK1						V				V
GBP3						V				V
XIAP						V				V
TANK						V				V		V
NAMPT						V				V
IFI16						V				V
RIPK1						V
OAS3						V				V		V
CCL2						V				V		V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
VDAC2							V
TAB2								V		V
HSP90AA1								V
CHUK										V
MAP3K7										V		V
IRAK4										V
ITPR3										V
GBP1										V
PRKCD										V
RNASEL										V
NFKBIA												V
BIRC3												V
IL6												V
+ 04622: RIG-I-like receptor signaling pathway	1.9	0.2	0.9	0.1	0.4	0.4	1.7	0.7	0	1.9	0.1	0.6
DDX58	V
IFIH1	V									V
RELA	V		V		V
CASP8	V		V							V		V
TNF	V							V		V
NLRX1		V
ISG15			V		V
CXCL8			V
MAP3K1				V		V		V		V
NFKBIB					V				V		V
TMEM173					V
TANK						V				V		V
TBK1						V				V
RIPK1						V
SIKE1						V				V		V
DDX3X						V		V		V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
TKFC							V		V
IL12A							V
CASP10										V
CHUK										V
MAP3K7										V		V
IL12B										V
NFKBIA												V
+ 04623: Cytosolic DNA-sensing pathway	3	0.2	1	0	1.2	0.8	2.3	1.3	0.4	1.2	1	0.8
RELA	V		V		V
DDX58	V
CCL4L1	V					V		V		V
CCL4L2	V					V		V		V
CCL4	V					V		V		V
CCL5	V							V		V		V
CGAS	V									V
CASP1		V	V		V		V		V		V
IL1B			V		V		V		V
IL18			V		V		V		V		V
TMEM173					V
NFKBIB					V				V		V
PYCARD						V				V		V
AIM2						V				V		V
TBK1						V				V
RIPK1						V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
CHUK										V
IL6												V
NFKBIA												V
+ 04625: C-type lectin receptor signaling pathway	2.5	0.6	1.7	0.3	0.2	0.1	0.4	0.1	0.1	1.5	1.1	0.8
RELA	V		V		V
IL23A	V		V							V
CASP8	V		V							V		V
MAP3K14	V
TNF	V							V		V
AKT2	V		V							V		V
IRF1	V									V
NFKB2	V									V
CASP1		V	V		V		V		V		V
BCL3		V				V
CLEC1B		V		V					V		V
IL1B			V		V		V		V
PLCG2			V
PTGS2			V		V		V		V		V
MALT1				V		V
AKT3				V		V		V		V	V
EGR2					V				V		V
NRAS						V				V		V
PYCARD						V				V		V
PPP3CA						V						V
PIK3CA						V				V
IL12A							V
CHUK										V
IL12B										V
BCL10										V		V
PRKCD										V
ITPR3										V
IL6												V
NFKBIA												V
+ 04650: Natural killer cell mediated cytotoxicity	4.1	0	0.6	0	0.2	0.2	0.9	4	0.1	2.9	0.1	0.4
TNF	V							V		V
PRKCB	V							V
SH2D1B	V				V			V			V
ULBP2	V
KIR2DS2	V							V		V
KIR2DS4	V							V		V
KIR2DS5	V							V		V
KIR2DL1	V							V		V
KIR2DL2	V							V		V
KIR2DL3	V							V		V
KIR2DL4	V							V		V
KIR2DL5A	V							V		V
KIR3DL2	V							V		V
KIR3DL1	V							V		V
PLCG2			V
TNFRSF10B			V							V		V
ULBP1			V
ICAM2			V		V				V
KLRC2			V		V		V		V
KLRC1			V		V		V		V
TNFSF10				V		V		V		V		V
SOS1				V		V				V
SHC3					V				V		V
RAET1E					V
PPP3CA						V						V
SH3BP2						V						V
PTK2B						V				V		V
ICAM1						V				V
PIK3CA						V				V
BRAF						V				V
NRAS						V				V		V
SHC2						V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
KLRC3							V		V
FYN								V
ITGAL									V
HLA-C										V		V
HLA-B										V
SOS2										V
RAC1										V		V
VAV2										V
+ 04612: Antigen processing and presentation	5.4	3.7	2.3	0.2	0.3	2	3.4	5	0.1	4.7	0	2.4
NFYC	V		V		V					V
KIR2DS2	V							V		V
KIR3DL3	V							V		V
KIR2DL1	V							V		V
KIR2DL2	V							V		V
KIR2DL3	V							V		V
KIR2DL4	V							V		V
KIR2DS4	V							V		V
KIR2DS5	V							V		V
KIR3DL1	V							V		V
KIR3DL2	V							V		V
KIR2DL5A	V							V		V
HSPA1B	V							V		V
TNF	V							V		V
CD74		V				V				V		V
HLA-DMA		V		V		V	V					V
HLA-DMB		V				V	V					V
CIITA		V
HLA-DPA1		V	V			V	V			V		V
HLA-DRA		V	V			V	V					V
HLA-DRB1		V	V			V	V					V
HLA-DRB3		V	V			V	V					V
HLA-DRB4		V	V			V	V					V
KLRC1			V		V		V		V
KLRC2			V		V		V		V
TAP2				V		V
PSME3					V
CREB1						V				V
TAPBP						V				V
HLA-F						V				V		V
HSPA1A						V				V
KLRC3							V		V
HLA-DOA							V					V
HSP90AA1								V
HLA-B										V
HLA-C										V		V
TAP1										V
+ 04660: T cell receptor signaling pathway	0.9	0.1	0.2	1.3	0.1	0.8	0.1	1	0.1	2.1	0.5	1.7
TNF	V							V		V
RELA	V		V		V
MAP3K14	V
AKT2	V		V							V		V
CD3D		V	V		V		V		V			V
AKT3				V		V		V		V	V
MALT1				V		V
SOS1				V		V				V
PAK6				V		V				V		V
CTLA4				V
DLG1				V		V		V		V
NFKBIB					V				V		V
FOS					V				V		V
MAP3K8						V				V
PIK3CA						V				V
NRAS						V				V		V
PPP3CA						V						V
PAK2						V				V
NCK2						V				V		V
CARD11							V					V
FYN								V
PTPRC								V		V
CD40LG									V
CHUK										V
BCL10										V		V
SOS2										V
VAV2										V
MAP3K7										V		V
NFKBIA												V
GRAP2												V
+ 04658: Th1 and Th2 cell differentiation	0.3	3.3	1.6	0.4	0.9	0.8	3	0	0.2	0	0.5	2.6
RELA	V		V		V
IL2RG	V				V
CD3D		V	V		V		V		V			V
MAF		V					V					V
HLA-DMA		V		V		V	V					V
HLA-DMB		V				V	V					V
HLA-DPA1		V	V			V	V			V		V
HLA-DRA		V	V			V	V					V
HLA-DRB1		V	V			V	V					V
HLA-DRB3		V	V			V	V					V
HLA-DRB4		V	V			V	V					V
MAML2				V
RBPJ				V		V
NFKBIB					V				V		V
FOS					V				V		V
JAG1					V				V
TYK2					V						V
PPP3CA						V						V
GATA3						V				V
IL12A							V
HLA-DOA							V					V
MAML3									V
CHUK										V
IL12B										V
NOTCH2										V		V
NFKBIA												V
+ 04659: Th17 cell differentiation	0.5	2.6	2.3	0.1	1.1	1.8	3	0.3	0.2	0.2	0.4	3
RELA	V		V		V
IL2RG	V				V
IL23A	V		V							V
HLA-DMA		V		V		V	V					V
HLA-DMB		V				V	V					V
HLA-DPA1		V	V			V	V			V		V
HLA-DRA		V	V			V	V					V
HLA-DRB1		V	V			V	V					V
HLA-DRB3		V	V			V	V					V
HLA-DRB4		V	V			V	V					V
CD3D		V	V		V		V		V			V
IL6R			V		V		V		V
IL1B			V		V		V		V
HIF1A				V		V		V		V
NFKBIB					V				V		V
FOS					V				V		V
IRF4					V				V
TYK2					V						V
PPP3CA						V						V
IL1R1						V				V		V
IL6ST						V
TGFBR1						V				V		V
GATA3						V				V
SMAD2						V				V		V
SMAD3						V
AHR						V		V		V		V
HLA-DOA							V					V
IL1RAP							V
HSP90AA1								V
CHUK										V
NFKBIA												V
IL6												V
+ 04657: IL-17 signaling pathway	1.4	0.4	4	0.1	3.9	0.2	3.3	1.2	3	0.4	1.3	0.7
RELA	V		V		V
CASP8	V		V							V		V
TNFAIP3	V		V		V				V		V
MMP1	V		V		V		V		V
TNF	V							V		V
SRSF1		V				V
LCN2		V				V	V					V
CXCL1			V		V		V		V
CXCL2			V		V		V		V
CCL20			V		V		V		V
DEFB4B			V		V		V		V
DEFB4A			V		V		V		V
MMP9			V				V					V
CXCL8			V
MMP3			V		V		V		V		V
PTGS2			V		V		V		V		V
IL1B			V		V		V		V
TAB3				V		V				V
USP25				V		V
FOS					V				V		V
FOSB					V
MAPK15					V				V
CEBPB					V
CXCL3					V		V		V
S100A9					V
MAPK6						V				V
CCL2						V				V		V
TBK1						V				V
TAB2								V		V
IL17C								V
HSP90AA1								V
CCL11								V
MUC5AC									V
MMP13									V
MAP3K7										V		V
CHUK										V
TRAF3IP2											V
IL6												V
NFKBIA												V
+ 04662: B cell receptor signaling pathway	1.2	0	1.1	0.5	0.5	0.2	0.7	0.6	0.2	1.2	0.7	1.3
RELA	V		V		V
AKT2	V		V							V		V
PRKCB	V							V
PIK3AP1	V		V		V		V		V			V
PLCG2			V
LILRA1			V				V
MALT1				V		V
AKT3				V		V		V		V	V
SOS1				V		V				V
NFKBIB					V				V		V
FOS					V				V		V
CD22					V		V		V
PIK3CA						V				V
NRAS						V				V		V
PPP3CA						V						V
CARD11							V					V
LILRA3								V		V
CHUK										V
BCL10										V		V
VAV2										V
RAC1										V		V
SOS2										V
NFKBIA												V
+ 04664: Fc epsilon RI signaling pathway	1	0.6	0.5	0.7	0.2	0.2	0.2	0.8	0.2	1.4	0.5	0.4
TNF	V							V		V
AKT2	V		V							V		V
PLA2G4A	V		V		V		V		V
MAP2K6		V					V
ALOX5		V		V		V				V		V
PLCG2			V
AKT3				V		V		V		V	V
SOS1				V		V				V
GAB2					V				V
PLA2G4C					V				V		V
PIK3CA						V				V
NRAS						V				V		V
FYN								V
SOS2										V
RAC1										V		V
VAV2										V
+ 04666: Fc gamma R-mediated phagocytosis	1	0.1	1.2	0.4	0.3	1.5	0.8	0.8	0.4	3.2	0.9	1
PLA2G4A	V		V		V		V		V
AKT2	V		V							V		V
SPHK1	V		V		V				V		V
PRKCB	V							V
NCF1		V					V
FCGR2A			V				V			V		V
PLCG2			V
SCIN			V
AKT3				V		V		V		V	V
DOCK2				V		V
ASAP1				V		V				V		V
PLA2G4C					V				V		V
WASF3					V		V		V
GAB2					V				V
PIK3CA						V				V
RPS6KB1						V				V
PLD1						V				V
LIMK1						V
CFL1						V				V		V
CFL2						V		V		V
ASAP3						V				V		V
ASAP2						V				V
MARCKS						V				V
BIN1						V				V		V
PRKCE							V					V
PTPRC								V		V
MARCKSL1									V
PRKCD										V
VAV2										V
RAC1										V		V
WASF1										V
GSN										V
ARF6										V
PLPP3											V
+ 04670: Leukocyte transendothelial migration	0.4	0.2	1.5	1.1	0.1	0.4	1.5	1.6	0.4	0.8	0.4	0.7
PRKCB	V							V
NCF2	V		V		V			V
CXCR4	V				V			V			V
MYL5		V					V		V
NCF1		V					V
CLDN7			V									V
ESAM			V		V		V		V
MMP9			V				V					V
F11R			V
RAPGEF3			V		V				V		V
THY1			V				V					V
PLCG2			V
CLDN11				V		V		V		V		V
CLDN2				V		V		V		V
CLDN9				V				V			V
ROCK1				V		V
ROCK2				V		V				V		V
ARHGAP5				V		V				V		V
AFDN						V
PIK3CA						V				V
TXK						V
PTK2B						V				V		V
ICAM1						V				V
OCLN							V		V
CLDN3							V		V
RASSF5							V
CXCL12								V		V
CLDN16									V
ITGAL									V
ARHGAP35										V
RAC1										V		V
RAP1A										V
VAV2										V
GNAI3										V
+ 04672: Intestinal immune network for IgA production	0.8	3.6	2.3	0.6	0.5	2.3	3.7	0.6	0.4	0.3	0.3	3.6
MAP3K14	V
CXCR4	V				V			V			V
HLA-DMA		V		V		V	V					V
HLA-DMB		V				V	V					V
HLA-DPA1		V	V			V	V			V		V
HLA-DRA		V	V			V	V					V
HLA-DRB1		V	V			V	V					V
HLA-DRB3		V	V			V	V					V
HLA-DRB4		V	V			V	V					V
IL15RA			V
ICOSLG				V		V				V		V
CCR10					V				V
LTBR					V		V		V
CD40						V				V		V
IL15						V
HLA-DOA							V					V
CXCL12								V		V
CD40LG									V
IL6												V
+ 04062: Chemokine signaling pathway	3.7	0	1.2	0.7	1.3	0.5	0.5	2.9	1.2	3.4	0.5	1.9
CCR6	V									V
CXCR4	V				V			V			V
CCL26	V
CCL4L1	V					V		V		V
CCL4L2	V					V		V		V
CCL4	V					V		V		V
CCL3L3	V		V		V			V		V		V
CCL3L1	V		V		V			V		V		V
CCL3	V		V		V			V		V		V
CCL5	V							V		V		V
CXCL11	V									V		V
GNGT2	V							V		V
PRKCB	V							V
AKT2	V		V							V		V
RELA	V		V		V
PREX1	V
GRK1		V					V		V
NCF1		V					V
CXCL1			V		V		V		V
CXCL2			V		V		V		V
CXCL8			V
CCL20			V		V		V		V
PLCB1			V				V					V
PIK3CG			V		V		V		V
CCR2				V							V
CXCL16				V				V		V
ROCK1				V		V
ROCK2				V		V				V		V
PRKACB				V		V		V		V		V
AKT3				V		V		V		V	V
DOCK2				V		V
SOS1				V		V				V
CCR10					V				V
CXCL3					V		V		V
CCL18					V
SHC3					V				V		V
GNB3					V				V		V
GNG5					V
NFKBIB					V				V		V
CCL2						V				V		V
PIK3CA						V				V
SHC2						V
GNG10						V						V
GNB4						V
TIAM1						V				V		V
PTK2B						V				V		V
NRAS						V				V		V
BRAF						V				V
CCL11								V
CXCL12								V		V
CCR8									V
CXCL9									V
PF4									V
XCL1									V
XCL2									V
FGR									V
ADCY1									V
CCL13										V		V
GNAI3										V
GNB1										V		V
GNG4										V
GRK3										V
VAV2										V
ADCY5										V
RAP1A										V
PRKCD										V
RAC1										V		V
CHUK										V
SOS2										V
CX3CL1												V
NFKBIA												V
+ 5.2 Endocrine system	5.2	1.6	5.3	4	2.9	4.1	4.5	6.5	2.7	5.6	4.1	3.6
+ 04911: Insulin secretion	0.3	0.8	1.3	0.4	0.4	0.7	2.8	2.1	1.3	1.1	1	1.2
PRKCB	V							V
CREB5	V		V							V
RIMS2		V	V		V		V		V
PCLO		V					V		V
KCNN1		V					V		V
KCNJ11			V
PLCB1			V				V					V
CREB3L3			V				V					V
KCNMB4			V			V	V			V		V
PRKACB				V		V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
ATP1A3					V				V		V
SNAP25					V		V		V
KCNU1					V				V		V
KCNN2					V				V		V
SLC2A1						V						V
CREB1						V				V
CREB3L1						V				V
CAMK2B						V		V		V
ATP1B1						V
ATF4							V
ATP1B2							V
KCNN4							V					V
ATP1A4								V			V
RAB3A								V		V
CACNA1F									V
ADCY1									V
ADCY5										V
ITPR3										V
+ 04910: Insulin signaling pathway	0.5	0.1	0.2	1.4	0	2.4	0.3	0.9	0.1	0.9	0.7	0.3
PPP1R3C	V							V		V
SORBS1	V		V									V
AKT2	V		V							V		V
IRS2	V				V			V			V
PDE3B		V					V		V
SREBF1		V		V		V
SOCS2			V				V					V
G6PC3			V			V	V			V		V
PRKAA2				V		V				V		V
PPP1CB				V		V				V
PHKB				V		V		V		V
PRKACB				V		V		V		V		V
ACACA				V
SOS1				V		V				V
AKT3				V		V		V		V	V
INPP5K					V						V
SHC3					V				V		V
FBP2					V						V
PTPRF						V
SOCS4						V
SOCS1						V
PRKAA1						V		V		V
PRKAR1B						V						V
NRAS						V				V		V
SHC2						V
RPS6KB1						V				V
BRAF						V				V
PCK2						V
FBP1						V				V
PIK3CA						V				V
PRKCI						V
IRS1						V
SOCS3							V		V
PRKAR2B							V		V
RPTOR									V
EIF4E									V
SOS2										V
+ 04922: Glucagon signaling pathway	0.2	0.1	1.3	1.9	0	2.2	1	1.8	0	2.1	0	1.4
CREB5	V		V							V
AKT2	V		V							V		V
PDE3B		V					V		V
PLCB1			V				V					V
CREB3L3			V				V					V
G6PC3			V			V	V			V		V
PRMT1			V
CPT1A			V		V		V
PRKACB				V		V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
AKT3				V		V		V		V	V
PHKB				V		V		V		V
ACACA				V
PRKAA2				V		V				V		V
PPARA				V		V				V
SLC2A1						V						V
CREB1						V				V
CREB3L1						V				V
PPP4R3B						V				V
PCK2						V
PPP3CA						V						V
FBP1						V				V
PRKAA1						V		V		V
CAMK2B						V		V		V
ATF4							V
ITPR3										V
+ 04923: Regulation of lipolysis in adipocytes	0.7	0.8	0.8	0.9	1.1	0.7	1.2	1	1.2	0.9	2.1	0.3
IRS2	V				V			V			V
AKT2	V		V							V		V
PDE3B		V					V		V
PLAAT3		V					V
ADRB1			V		V		V		V
PTGS2			V		V		V		V		V
PRKACB				V		V		V		V		V
ABHD5				V		V
AKT3				V		V		V		V	V
AQP7					V				V		V
FABP4					V				V		V
PIK3CA						V				V
IRS1						V
PTGS1						V				V		V
ADCY1									V
ADCY5										V
GNAI3										V
+ 04920: Adipocytokine signaling pathway	1.4	0	0.9	1.9	0.7	2	0.5	2.9	0	2.2	0.9	1.3
RELA	V		V		V
AKT2	V		V							V		V
IRS2	V				V			V			V
TNF	V							V		V
CPT1A			V		V		V
G6PC3			V			V	V			V		V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
PRKAA2				V		V				V		V
PPARA				V		V				V
LEPR				V		V		V		V		V
AKT3				V		V		V		V	V
NFKBIB					V				V		V
ADIPOR2					V
PCK2						V
PRKAA1						V		V		V
SLC2A1						V						V
TNFRSF1B						V				V		V
IRS1						V
SOCS3							V		V
ACSL6								V		V
CHUK										V
NFKBIA												V
+ 03320: PPAR signaling pathway	0.8	1	3.1	1.4	2.6	0.5	2.4	1.1	1.7	0.4	0.8	0.1
PLIN2	V		V		V
SORBS1	V		V									V
MMP1	V		V		V		V		V
PPARG		V
SCD		V		V		V
SCD5		V					V		V
SLC27A2			V		V		V		V
FABP5			V		V		V		V
ACADL			V
CPT1A			V		V		V
OLR1			V
ANGPTL4			V		V		V		V		V
ACOX2			V		V		V		V
PPARA				V		V				V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
HMGCS2				V				V
AQP7					V				V		V
SLC27A4					V
FABP4					V				V		V
FABP6					V				V
PCK2						V
SCP2						V				V
ME1						V				V		V
LPL							V
ACSL6								V		V
ACADM										V
FABP2												V
+ 04912: GnRH signaling pathway	1	0.4	0.3	1	0.2	0.5	0.8	0.8	0.2	0.9	0.2	0.1
PRKCB	V							V
MAP3K3	V				V
PLA2G4A	V		V		V		V		V
EGR1	V		V		V		V		V		V
MAP2K6		V					V
MAP3K2		V		V		V
PLCB1			V				V					V
MAP3K1				V		V		V		V
GNRH1				V		V
PRKACB				V		V		V		V		V
SOS1				V		V				V
PLA2G4C					V				V		V
CAMK2B						V		V		V
PLD1						V				V
NRAS						V				V		V
PTK2B						V				V		V
ATF4							V
ADCY1									V
CACNA1F									V
PRKCD										V
ADCY5										V
ITPR3										V
SOS2										V
+ 04913: Ovarian steroidogenesis	2.9	0.3	2.8	1	3.3	0.3	0.9	1.6	2.2	0.8	1.8	0.8
HSD3B1	V		V		V			V		V
HSD3B2	V		V		V
AKR1C3	V			V		V		V		V		V
CYP1A1	V		V		V				V
IGF1	V		V		V
PLA2G4A	V		V		V		V		V
ALOX5		V		V		V				V		V
CYP2J2			V		V		V		V
PTGS2			V		V		V		V		V
PRKACB				V		V		V		V		V
HSD17B2					V				V		V
ACOT2					V				V		V
PLA2G4C					V				V		V
CYP1B1						V		V		V		V
ADCY1									V
ADCY5										V
+ 04915: Estrogen signaling pathway	1.9	0	1.1	0.7	0.4	0.6	0.3	1.9	0	2.6	1	0.9
CREB5	V		V							V
AKT2	V		V							V		V
FKBP5	V
HSPA1B	V							V		V
KRT34	V				V			V			V
KRT17	V		V		V			V		V	V
KRT32	V		V
MMP9			V				V					V
CREB3L3			V				V					V
PLCB1			V				V					V
TGFA			V		V		V		V			V
PRKACB				V		V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
AKT3				V		V		V		V	V
SOS1				V		V				V
NCOA2				V		V				V
FOS					V				V		V
GABBR2					V
SHC3					V				V		V
FKBP4					V				V
GPER1						V				V		V
NRAS						V				V		V
CREB1						V				V
CREB3L1						V				V
PIK3CA						V				V
NOS3						V				V
SHC2						V
HSPA1A						V				V
ATF4							V
HSP90AA1								V
ADCY1									V
PRKCD										V
ADCY5										V
SOS2										V
GNAI3										V
ITPR3										V
NCOA1										V
KRT40										V
PGR												V
+ 04914: Progesterone-mediated oocyte maturation	0.6	0.7	2.2	0.3	0	0.5	0.8	0.8	0.6	1.3	0.1	1.6
IGF1	V		V		V
AKT2	V		V							V		V
CDC27	V		V							V		V
PDE3B		V					V		V
RPS6KA2		V				V				V		V
CCNA1		V					V		V
CDC25A			V
SPDYE1			V
SPDYE3			V
SPDYE5			V
SPDYE6			V
AURKA			V				V					V
AKT3				V		V		V		V	V
PRKACB				V		V		V		V		V
RPS6KA3				V		V				V		V
MAD1L1					V				V
CPEB4						V				V
CDK1						V				V		V
PIK3CA						V				V
MAD2L1						V						V
BRAF						V				V
ANAPC11							V		V
CCNA2							V					V
HSP90AA1								V
SPDYA								V		V
CPEB1									V
ADCY1									V
KIF22									V
ADCY5										V
GNAI3										V
PGR												V
+ 04917: Prolactin signaling pathway	1.4	0	1.3	0.6	1	1.1	0.9	0.1	0.5	0.7	1.3	0.6
AKT2	V		V							V		V
PRLR	V				V	V
IRF1	V									V
RELA	V		V		V
SOCS2			V				V					V
CCND2			V		V		V		V		V
TNFRSF11A			V		V		V		V
AKT3				V		V		V		V	V
SOS1				V		V				V
SOCS6				V		V				V		V
SHC3					V				V		V
FOS					V				V		V
PIK3CA						V				V
NRAS						V				V		V
SHC2						V
SOCS4						V
SOCS1						V
SOCS3							V		V
SOS2										V
CSN2												V
+ 04921: Oxytocin signaling pathway	1.3	0	0.9	0.8	0.6	0.4	0.4	1.3	0.8	0.5	0.9	0.2
PRKCB	V							V
PLA2G4A	V		V		V		V		V
GUCY1A1	V										V
MYL6	V
CACNA2D4	V		V		V				V		V
CDKN1A	V							V
KCNJ14	V									V
PLCB1			V				V					V
PTGS2			V		V		V		V		V
RGS2			V		V		V		V
MEF2C			V		V				V
CD38			V		V
PIK3CG			V		V		V		V
MYLK				V		V		V		V		V
PRKACB				V		V		V		V		V
OXTR				V		V		V		V
ROCK1				V		V
ROCK2				V		V				V		V
PPP1CB				V		V				V
PRKAA2				V		V				V		V
PLA2G4C					V				V		V
CACNB1					V				V		V
FOS					V				V		V
MYLK4						V				V
NRAS						V				V		V
CAMK2B						V		V		V
NOS3						V				V
PPP1R12A						V
PRKAA1						V		V		V
PPP3CA						V						V
CACNB4							V					V
CACNG2								V
ADCY1									V
PPP1R12B									V
CACNA1F									V
ITPR3										V
ADCY5										V
GNAI3										V
+ 04926: Relaxin signaling pathway	2	0.4	1.2	0.8	0.3	1.9	1.2	2	0.2	3.1	0.8	2.1
AKT2	V		V							V		V
RELA	V		V		V
GNGT2	V							V		V
CREB5	V		V							V
NOS1	V							V		V
COL1A1	V							V		V
COL1A2	V							V		V
MMP1	V		V		V		V		V
VEGFB		V
COL4A4		V				V	V
COL4A5		V					V
CREB3L3			V				V					V
MMP9			V				V					V
COL4A6			V				V
PLCB1			V				V					V
AKT3				V		V		V		V	V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
PRKACB				V		V		V		V		V
EDNRB				V		V		V		V		V
SOS1				V		V				V
GNB3					V				V		V
GNG5					V
EDN1					V				V		V
SHC3					V				V		V
FOS					V				V		V
NOS3						V				V
PIK3CA						V				V
GNG10						V						V
GNB4						V
CREB1						V				V
CREB3L1						V				V
VEGFA						V				V		V
SMAD2						V				V		V
SMAD3						V
NRAS						V				V		V
SHC2						V
TGFBR1						V				V		V
ATF4							V
MMP13									V
ADCY1									V
GNB1										V		V
GNG4										V
ADCY5										V
GNAI3										V
SOS2										V
NFKBIA												V
+ 04918: Thyroid hormone synthesis	0.4	0	0.8	0.6	0.1	0.7	0.8	1.5	0.1	0.9	0.4	0.8
PRKCB	V							V
CREB5	V		V							V
PLCB1			V				V					V
CREB3L3			V				V					V
ASGR1			V		V				V
PRKACB				V		V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
ATP1A3					V				V		V
TG						V
ATP1B1						V
CREB1						V				V
CREB3L1						V				V
GPX7						V						V
ATP1B2							V
ATF4							V
ATP1A4								V			V
ADCY1									V
ADCY5										V
ITPR3										V
GPX8										V
+ 04919: Thyroid hormone signaling pathway	0.2	0	0.3	1	0	0.8	0.3	1.5	0	0.7	1.7	0.4
AKT2	V		V							V		V
PRKCB	V							V
PLCB1			V				V					V
PLCG2			V
MYC			V				V
AKT3				V		V		V		V	V
HIF1A				V		V		V		V
PRKACB				V		V		V		V		V
SLC16A2				V				V			V
NCOA2				V		V				V
BMP4				V		V		V		V
PLCD4					V
TBC1D4					V						V
ATP1A3					V				V		V
ITGAV						V				V		V
PIK3CA						V				V
NRAS						V				V		V
SLC2A1						V						V
ATP1B1						V
KAT2B						V				V
MED14						V
MED13						V				V
RCAN2							V
ATP1B2							V
ATP1A4								V			V
PLCE1									V
DIO2									V		V
MED12L									V
NCOA1										V
NOTCH2										V		V
THRB											V
+ 04928: Parathyroid hormone synthesis, secretion and action	2.8	0.3	2	0.3	1.1	0.9	1.3	1.7	1.1	1.5	0.7	0.8
PRKCB	V							V
CYP27B1	V		V		V
CYP24A1	V		V		V
CREB5	V		V							V
CDKN1A	V							V
SLC34A1	V							V		V
NR4A2	V		V		V		V		V
KL	V							V
EGR1	V		V		V		V		V		V
PDE4D		V					V
LRP5		V					V
PLCB1			V				V					V
CREB3L3			V				V					V
NACA			V									V
MEF2C			V		V				V
PRKACB				V		V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
PTHLH					V				V		V
MMP15					V				V
MMP16					V				V		V
FOS					V				V		V
GATA3						V				V
BRAF						V				V
GNA13						V				V		V
PLD1						V				V
SOST						V
CREB1						V				V
CREB3L1						V				V
RUNX2						V				V
MEF2A						V
ATF4							V
ADCY1									V
LRP6									V
MMP13									V
ITPR3										V
ADCY5										V
GNAI3										V
MEF2D												V
+ 04916: Melanogenesis	0.2	0.3	0.4	0.6	0.1	0.6	1.1	1.8	0.7	1.1	1.2	0.6
PRKCB	V							V
WNT11	V			V				V		V
TYR		V					V		V
TCF7		V					V		V
PLCB1			V				V					V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
CREB3L3			V				V					V
PRKACB				V		V		V		V		V
EDNRB				V		V		V		V		V
CREB3L2				V		V		V		V		V
FZD4					V				V		V
WNT5B					V				V		V
EDN1					V				V		V
CAMK2B						V		V		V
KITLG						V
FZD6						V				V
FZD7						V		V		V
CREB1						V				V
CREB3L1						V				V
NRAS						V				V		V
ADCY1									V
WNT10B									V
GNAI3										V
ADCY5										V
WNT2										V
MITF											V
+ 04924: Renin secretion	0.5	1.1	0.2	0.6	0.4	0.4	0.9	0.1	0.8	0.3	0.9	0.4
GUCY1A1	V										V
PTGER4	V				V
PDE3B		V					V		V
EDNRA		V		V		V
EDN2		V		V		V
ADRB1			V		V		V		V
PLCB1			V				V					V
PRKACB				V		V		V		V		V
PDE1C					V				V		V
EDN1					V				V		V
CREB1						V				V
PPP3CA						V						V
AQP1						V				V		V
PTGER2							V
CLCA2									V
CACNA1F									V
ADCY5										V
GNAI3										V
ITPR3										V
+ 04614: Renin-angiotensin system	0	0.7	0	0	0	0.1	0.5	0.6	0.2	0.4	1.4	0.7
KLK2		V					V		V		V
PRCP						V				V		V
CTSG								V
KLK1										V		V
CPA3											V
+ 04925: Aldosterone synthesis and secretion	2.6	0.1	1.8	0.9	0.7	0.8	1.5	3	0.5	1.7	0.8	0.9
CACNA1H	V
CACNA1G	V							V
CREB5	V		V							V
PRKCB	V							V
PRKD1	V		V		V			V		V
NR4A2	V		V		V		V		V
HSD3B1	V		V		V			V		V
HSD3B2	V		V		V
CYP11B2		V		V					V		V
PLCB1			V				V					V
CREB3L3			V				V					V
PDE2A			V		V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
PRKACB				V		V		V		V		V
ATP2B1				V		V		V		V
NR4A1					V
ATP1A3					V				V		V
KCNK9						V				V		V
CREB1						V				V
CREB3L1						V				V
CAMK2B						V		V		V
ATF1						V				V
ATP1B1						V
ATP2B4						V				V		V
ATF4							V
PRKCE							V					V
ATP1B2							V
ATP1A4								V			V
CACNA1F									V
ADCY1									V
DAGLA									V
ITPR3										V
ADCY5										V
+ 04927: Cortisol synthesis and secretion	2	0.2	1.4	1.1	0.2	0.5	0.6	1.7	0.1	1.5	0.1	0.7
CACNA1H	V
CACNA1G	V							V
CREB5	V		V							V
HSD3B1	V		V		V			V		V
HSD3B2	V		V		V
PBX1		V		V		V				V
PLCB1			V				V					V
CREB3L3			V				V					V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
PRKACB				V		V		V		V		V
NR4A1					V
CREB1						V				V
CREB3L1						V				V
ATF4							V
CACNA1F									V
ADCY1									V
ITPR3										V
ADCY5										V
KCNK2											V
+ 5.3 Circulatory system	1	0.5	1.4	1.6	1.1	0.9	1.3	1.6	1.4	0.9	2.8	0.8
+ 04260: Cardiac muscle contraction	0.3	0.1	0.6	0	1	0	0.6	0.5	0.8	0	1.9	0
CACNA2D4	V		V		V				V		V
COX7B2	V		V		V		V		V		V
ASPH		V		V		V	V	V	V	V
UQCRHL			V
UQCRH			V
CACNB1					V				V		V
TPM4					V						V
UQCRQ					V
ATP1A3					V				V		V
TRDN					V
ATP1B1						V
CACNB4							V					V
ATP1B2							V
CACNG2								V
ATP1A4								V			V
CACNA1F									V
TPM2									V
COX7A2										V		V
+ 04261: Adrenergic signaling in cardiomyocytes	0.2	0	1.2	0.9	0.5	0.3	0.9	1.7	0.8	0.8	1.9	0.6
CACNA2D4	V		V		V				V		V
AKT2	V		V							V		V
CREB5	V		V							V
SCN5A		V			V				V		V
ADRB1			V		V		V		V
PIK3CG			V		V		V		V
CREB3L3			V				V					V
SCN7A			V				V		V
PLCB1			V				V					V
RAPGEF3			V		V				V		V
PRKACB				V		V		V		V		V
AKT3				V		V		V		V	V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
PPP1CB				V		V				V
PPP2R3A				V		V
ATP2B1				V		V		V		V
CACNB1					V				V		V
TPM4					V						V
ATP1A3					V				V		V
PPP2R2C					V				V		V
ATP1B1						V
CREB1						V				V
CREB3L1						V				V
CAMK2B						V		V		V
ATP2B4						V				V		V
KCNE1						V				V		V
CACNB4							V					V
ATP1B2							V
ATF4							V
CACNG2								V
ATP1A4								V			V
RPS6KA5								V		V
CACNA1F									V
TPM2									V
ADCY1									V
GNAI3										V
ADCY5										V
KCNQ1										V		V
+ 04270: Vascular smooth muscle contraction	1.3	0.7	0.6	1.8	0.5	1.2	0.6	0.6	0.9	0.7	1.1	0.8
MYL6	V
PRKCB	V							V
PLA2G4A	V		V		V		V		V
GUCY1A1	V										V
MRVI1	V		V		V
ADM	V		V			V	V			V		V
PLA2G5		V				V
EDNRA		V		V		V
NPPB		V					V		V
EDN2		V		V		V
PLCB1			V				V					V
KCNMB4			V			V	V			V		V
ADORA2B			V
MYLK				V		V		V		V		V
PPP1CB				V		V				V
ROCK1				V		V
ROCK2				V		V				V		V
CALD1				V		V		V		V
ADORA2A				V		V		V		V		V
PRKACB				V		V		V		V		V
PRKCH					V				V
ACTG2					V				V		V
KCNU1					V				V		V
PLA2G4C					V				V		V
CALCRL					V				V		V
EDN1					V				V		V
MYLK4						V				V
PPP1R12A						V
GNA13						V				V		V
BRAF						V				V
PRKCE							V					V
PPP1R12B									V
CACNA1F									V
ADCY1									V
PRKCD										V
ITPR3										V
ADCY5										V
CALCB												V
+ 5.4 Digestive system	1.5	1.8	2.5	1.6	1.2	1.4	4.2	3.1	1.5	1.4	3	1.8
+ 04970: Salivary secretion	0.7	0.4	1.3	0.4	0.1	0.1	2	1.2	0.1	0.1	0.6	0.8
PRKCB	V							V
NOS1	V							V		V
GUCY1A1	V										V
AQP5		V		V
DMBT1		V				V	V
ADRB1			V		V		V		V
PLCB1			V				V					V
CD38			V		V
CST1			V				V					V
CST2			V				V					V
CST4			V				V					V
PRKACB				V		V		V		V		V
ATP2B1				V		V		V		V
ATP1A3					V				V		V
ATP2B4						V				V		V
ATP1B1						V
KCNN4							V					V
ATP1B2							V
ATP1A4								V			V
ADCY1									V
PRH1									V
ADCY5										V
ITPR3										V
+ 04971: Gastric acid secretion	0.4	0	0.2	0.3	0	0.1	1.2	1.9	0	0.9	0.8	0.5
PRKCB	V							V
SST	V							V		V
PLCB1			V				V					V
CA2			V				V					V
PRKACB				V		V		V		V		V
MYLK				V		V		V		V		V
ATP1A3					V				V		V
ATP1B1						V
MYLK4						V				V
CAMK2B						V		V		V
CCKBR							V
ATP1B2							V
SLC26A7							V
ATP1A4								V			V
ADCY1									V
ADCY5										V
ITPR3										V
KCNQ1										V		V
GNAI3										V
KCNK2											V
+ 04972: Pancreatic secretion	0.1	0.3	0.5	0	0.1	0.3	0.8	0.4	0.1	0.2	0.5	0.4
PRKCB	V							V
SCTR		V				V	V					V
PLA2G5		V				V
PLCB1			V				V					V
CA2			V				V					V
PRSS3			V		V		V		V
CD38			V		V
ATP2B1				V		V		V		V
ATP1A3					V				V		V
ATP2B4						V				V		V
ATP1B1						V
SLC4A4						V
TRPC1						V				V
RAB27B						V
ATP1B2							V
ATP1A4								V			V
CLCA2									V
ADCY1									V
ITPR3										V
KCNQ1										V		V
ADCY5										V
RAP1A										V
RAC1										V		V
CPA3											V
+ 04976: Bile secretion	0	0.5	0.2	0.1	0.4	0.8	0.8	0.3	1.4	0.1	1.7	0.9
SCTR		V				V	V					V
EPHX1		V				V
CA2			V				V					V
SLCO1B3			V		V		V		V		V
PRKACB				V		V		V		V		V
ATP1A3					V				V		V
ABCG2					V				V
KCNN2					V				V		V
ATP1B1						V
SLC4A4						V
ABCC3						V				V		V
SLC2A1						V						V
AQP1						V				V		V
ATP1B2							V
ATP1A4								V			V
ADCY1									V
SLCO1A2									V		V
ABCB4									V
SLC4A5									V
ADCY5										V
SLC10A2										V
+ 04973: Carbohydrate digestion and absorption	0.9	0	0.5	0.2	0.3	0.7	0.5	1.2	0.2	0.7	1.9	0.9
AKT2	V		V							V		V
PRKCB	V							V
G6PC3			V			V	V			V		V
AKT3				V		V		V		V	V
ATP1A3					V				V		V
MGAM					V				V		V
ATP1B1						V
PIK3CA						V				V
GNAT3						V				V		V
ATP1B2							V
ATP1A4								V			V
SLC2A5												V
+ 04974: Protein digestion and absorption	1.9	1.2	0.6	1.5	0.2	1.1	2	1.6	0.7	2	1.4	1.4
SLC7A9	V							V
COL1A1	V							V		V
COL1A2	V							V		V
COL6A2	V					V				V		V
COL6A3	V		V							V		V
COL17A1	V							V		V
COL4A4		V				V	V
COL4A5		V					V
COL9A2		V				V
COL6A5		V		V			V		V		V
SLC1A1			V		V		V		V
PRSS3			V		V		V		V
COL4A6			V				V
SLC38A2				V		V				V
SLC7A7				V		V				V
SLC6A19				V					V		V
COL5A1				V		V				V		V
COL12A1				V		V		V		V
ATP1A3					V				V		V
COL27A1					V
ATP1B1						V
PRCP						V				V		V
COL15A1						V				V		V
COL18A1						V				V		V
ATP1B2							V
KCNN4							V					V
ATP1A4								V			V
KCNE3									V
COL9A1									V
KCNQ1										V		V
COL6A1										V
COL14A1										V
CPA3											V
COL13A1												V
+ 04975: Fat digestion and absorption	0	1.1	0	0.3	0.3	0.1	0	0.3	0	0	0.3	0.1
PLA2G5		V				V
ABCA1		V		V		V		V		V
SLC27A4					V
GOT2					V
PLPP3											V
FABP2												V
+ 04979: Cholesterol metabolism	0.8	0.3	0.5	0.6	0.2	0	1.4	1.1	0.4	0	1.3	0
LIPG	V		V		V
VAPB	V							V		V
ABCA1		V		V		V		V		V
ANGPTL4			V		V		V		V		V
MYLIP				V		V
APOC2							V		V
LPL							V
VDAC2							V
LCAT								V
PCSK9									V		V
LRP1											V
+ 04977: Vitamin digestion and absorption	0	1.5	1.7	0	1.9	0.1	1.1	0	1.7	0.4	0	0.7
LRAT		V	V		V		V		V
SLC19A3		V	V				V		V			V
SLC52A3			V		V				V
MMACHC					V				V
SLC23A1					V
LMBRD1						V				V
AWAT2										V		V
+ 04978: Mineral absorption	0	0.3	2.6	1.9	0.4	1.1	3.5	1.5	0.1	0.1	1.1	0
CLCN2		V		V		V
MT1A			V		V		V
MT1B			V				V
MT1E			V				V
MT1H			V				V
MT1X			V				V
MT2A			V				V
SLC26A6			V
ATP2B1				V		V		V		V
CYBRD1				V		V		V		V
ATP7A				V		V		V		V
SLC6A19				V					V		V
S100G					V
ATP1A3					V				V		V
STEAP2						V
ATP1B1						V
TRPM7						V
FTH1							V					V
SLC39A4							V
ATP1B2							V
ATP1A4								V			V
+ 5.5 Excretory system	1.5	1	1.7	0.9	1.2	2	2.3	2.2	0.7	0.8	1.8	1.3
+ 04962: Vasopressin-regulated water reabsorption	0.3	0.4	1	0.6	0.1	1.1	1	0.7	0	1	0	0.9
CREB5	V		V							V
AQP3		V				V	V					V
CREB3L3			V				V					V
DYNC1I1			V		V		V		V
PRKACB				V		V		V		V		V
CREB3L2				V		V		V		V		V
CREB1						V				V
CREB3L1						V				V
DYNC1I2						V				V
+ 04960: Aldosterone-regulated sodium reabsorption	1.6	1.1	0.7	0	1.2	0.6	1.2	0.9	0.3	0	0.9	0.1
SGK1	V		V		V
IGF1	V		V		V
PRKCB	V							V
SCNN1A		V				V	V					V
NR3C2		V			V		V		V
ATP1A3					V				V		V
ATP1B1						V
IRS1						V
PIK3CA						V				V
ATP1B2							V
ATP1A4								V			V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	1.3	0.8	0.1	1	0	0.3	0.9	2.1	0.1	0.3	1.2	0.4
BDKRB2	V									V
KL	V							V
PRKCB	V							V
DNM3		V		V		V
KLK2		V					V		V		V
PLCB1			V				V					V
ATP2B1				V		V		V		V
PRKACB				V		V		V		V		V
ATP1A3					V				V		V
ATP1B1						V
ATP1B2							V
ATP1A4								V			V
KLK1										V		V
+ 04964: Proximal tubule bicarbonate reclamation	0	0	0.5	0	0.3	1.8	1.1	1.3	0.7	0.4	1.4	1.3
CA2			V				V					V
ATP1A3					V				V		V
SLC4A4						V
GLS						V		V		V		V
ATP1B1						V
AQP1						V				V		V
PCK2						V
ATP1B2							V
ATP1A4								V			V
SLC38A3									V
+ 04966: Collecting duct acid secretion	0	0	1.6	0.4	1.1	0.6	1	0	0.5	0.1	0.5	0.2
ATP6V1B2			V
ATP6V0E1			V		V		V		V		V
CA2			V				V					V
ATP6V1G3				V
ATP6V0E2					V				V
ATP6V0A1					V
ATP6V0A4						V
ATP6V1A						V
SLC12A7						V				V
+ 5.6 Nervous system	2.7	0.2	1.7	2	1.5	1.7	1.3	3	1.1	3.9	1.9	1.8
+ 04724: Glutamatergic synapse	0.4	0.1	0.3	1.4	0.5	0.7	0.9	1.6	0.8	1.7	1	0.7
PRKCB	V							V
GNGT2	V							V		V
PLA2G4A	V		V		V		V		V
SHANK2		V		V		V				V
SLC1A1			V		V		V		V
PLCB1			V				V					V
HOMER2			V		V		V		V		V
GRIK2				V		V				V
SLC1A3				V		V		V		V
SLC38A2				V		V				V
PRKACB				V		V		V		V		V
GLUL				V				V			V
SLC1A7				V
GRM5					V		V		V		V
GNB3					V				V		V
GNG5					V
PLA2G4C					V				V		V
GRIK4						V				V		V
TRPC1						V				V
GNG10						V						V
GNB4						V
PPP3CA						V						V
GLS						V		V		V		V
PLD1						V				V
HOMER1							V
GRIA4								V
GRM4									V
ADCY1									V
SLC38A3									V
SLC1A2										V		V
ADCY5										V
ITPR3										V
GNAI3										V
GNB1										V		V
GNG4										V
GRK3										V
+ 04727: GABAergic synapse	0.7	0	0	0.4	0.1	0.1	0	1.2	0.1	0.7	0.3	0.3
GNGT2	V							V		V
SLC12A5	V
PRKCB	V							V
SLC32A1			V									V
GLUL				V				V			V
PRKACB				V		V		V		V		V
SLC38A2				V		V				V
GABBR2					V
GNB3					V				V		V
GNG5					V
GNG10						V						V
GNB4						V
GABRE						V				V
GLS						V		V		V		V
ADCY1									V
CACNA1F									V
SLC38A3									V
ADCY5										V
GNAI3										V
GNB1										V		V
GNG4										V
TRAK2										V
+ 04725: Cholinergic synapse	1.9	0	0.6	0.2	0.2	0.4	0.6	1.9	0.2	2.2	0.7	0.9
CHRM1	V							V		V
ACHE	V
PRKCB	V							V
GNGT2	V							V		V
KCNJ14	V									V
CREB5	V		V							V
AKT2	V		V							V		V
PLCB1			V				V					V
CREB3L3			V				V					V
PIK3CG			V		V		V		V
PRKACB				V		V		V		V		V
CREB3L2				V		V		V		V		V
AKT3				V		V		V		V	V
GNB3					V				V		V
GNG5					V
KCNQ3					V				V		V
FOS					V				V		V
GNG10						V						V
GNB4						V
CREB1						V				V
CREB3L1						V				V
CAMK2B						V		V		V
PIK3CA						V				V
NRAS						V				V		V
CHRNA6							V
ATF4							V
FYN								V
ADCY1									V
CACNA1F									V
ADCY5										V
ITPR3										V
GNAI3										V
GNB1										V		V
GNG4										V
KCNQ1										V		V
+ 04728: Dopaminergic synapse	0.9	0	0.6	1.4	0.2	1	0.2	2	0	1.7	0.8	0.8
SLC18A1	V				V
PRKCB	V							V
GNGT2	V							V		V
AKT2	V		V							V		V
CREB5	V		V							V
KIF5B		V		V		V		V		V
PLCB1			V				V					V
MAOA			V		V		V		V
MAOB			V			V				V		V
CREB3L3			V				V					V
PRKACB				V		V		V		V		V
AKT3				V		V		V		V	V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
PPP2R3A				V		V
PPP1CB				V		V				V
CLOCK				V		V				V
GNB3					V				V		V
GNG5					V
FOS					V				V		V
PPP2R2C					V				V		V
GNG10						V						V
GNB4						V
CREB1						V				V
CREB3L1						V				V
PPP3CA						V						V
CAMK2B						V		V		V
ATF4							V
GRIA4								V
LRTOMT									V
ADCY5										V
ITPR3										V
GNAI3										V
GNB1										V		V
GNG4										V
COMT											V
+ 04726: Serotonergic synapse	1.1	0.1	1.8	0.1	1.8	0.3	0.8	0.3	1.2	1.2	1.4	0.9
SLC18A1	V				V
PRKCB	V							V
GNGT2	V							V		V
PLA2G4A	V		V		V		V		V
CYP4X1	V									V
ALOX5		V		V		V				V		V
HTR7			V		V
PLCB1			V				V					V
RAPGEF3			V		V				V		V
MAOA			V		V		V		V
MAOB			V			V				V		V
CYP2J2			V		V		V		V
PTGS2			V		V		V		V		V
DUSP1			V		V		V		V		V
PRKACB				V		V		V		V		V
GNB3					V				V		V
GNG5					V
PLA2G4C					V				V		V
KCNN2					V				V		V
HTR1D						V
GNG10						V						V
GNB4						V
TRPC1						V				V
PTGS1						V				V		V
NRAS						V				V		V
BRAF						V				V
HTR1B									V
CACNA1F									V
ADCY5										V
ITPR3										V
GNAI3										V
GNB1										V		V
GNG4										V
ALOX12										V
HTR3A												V
+ 04720: Long-term potentiation	0.2	0.2	0.2	0.7	0.1	0.9	0.6	0.8	0.2	1.1	0.5	1
PRKCB	V							V
RPS6KA2		V				V				V		V
RAPGEF3			V		V				V		V
PLCB1			V				V					V
RPS6KA3				V		V				V		V
PRKACB				V		V		V		V		V
PPP1CB				V		V				V
GRM5					V		V		V		V
CAMK2B						V		V		V
PPP3CA						V						V
BRAF						V				V
NRAS						V				V		V
ATF4							V
ADCY1									V
RAP1A										V
ITPR3										V
+ 04730: Long-term depression	2.1	0	0.6	0	0.3	0.1	0.3	0.4	0.2	0.7	0.5	0.5
PLA2G4A	V		V		V		V		V
NOS1	V							V		V
PRKCB	V							V
IGF1	V		V		V
GUCY1A1	V										V
PLCB1			V				V					V
PLA2G4C					V				V		V
GNA13						V				V		V
BRAF						V				V
NRAS						V				V		V
GRID2									V
GNAI3										V
GNAZ										V		V
ITPR3										V
+ 04723: Retrograde endocannabinoid signaling	0.1	0	0.3	0	0.2	0	0	0.3	0.3	0	0.2	0.1
PRKCB	V							V
GNGT2	V							V		V
PLCB1			V				V					V
PTGS2			V		V		V		V		V
SLC32A1			V									V
NDUFA9			V		V				V
NDUFC2			V
PRKACB				V		V		V		V		V
NAPEPLD				V		V
GNB3					V				V		V
GNG5					V
GRM5					V		V		V		V
RIMS1					V
NDUFB9					V
GABRE						V				V
GNG10						V						V
GNB4						V
NDUFA5						V				V		V
GRIA4								V
CACNA1F									V
DAGLA									V
ADCY1									V
NDUFA3									V
NDUFB1									V
ITPR3										V
GNAI3										V
GNB1										V		V
GNG4										V
ADCY5										V
+ 04721: Synaptic vesicle cycle	0.1	0.1	0.7	0.9	1.5	0.1	0.7	0.3	0.4	0	0.3	0.1
SLC18A1	V				V
DNM3		V		V		V
SLC32A1			V									V
ATP6V1B2			V
ATP6V0E1			V		V		V		V		V
SLC1A1			V		V		V		V
ATP6V1G3				V
SLC1A3				V		V		V		V
SLC1A7				V
RIMS1					V
CPLX1					V				V		V
SNAP25					V		V		V
ATP6V0E2					V				V
ATP6V0A1					V
ATP6V0A4						V
ATP6V1A						V
SLC6A9						V
UNC13C							V					V
RAB3A								V		V
SLC1A2										V		V
+ 04722: Neurotrophin signaling pathway	1.1	0.2	0.3	1.3	0.1	1.7	0	0.8	0	2.7	0.3	0.6
NTF3	V			V		V		V		V
NGFR	V					V				V		V
AKT2	V		V							V		V
RELA	V		V		V
MAP3K3	V				V
BDNF		V		V		V
RPS6KA2		V				V				V		V
PLCG2			V
IRAK3			V				V					V
NGF				V		V				V
AKT3				V		V		V		V	V
SOS1				V		V				V
RPS6KA3				V		V				V		V
MAP3K1				V		V		V		V
SHC3					V				V		V
NFKBIB					V				V		V
PIK3CA						V				V
SHC2						V
NRAS						V				V		V
BRAF						V				V
FRS2						V				V
CAMK2B						V		V		V
IRS1						V
MAGED1						V				V
ATF4							V
RPS6KA5								V		V
PRKCD										V
SOS2										V
RAP1A										V
GAB1										V
RAC1										V		V
IRAK4										V
NFKBIA												V
+ 5.7 Sensory system	1.1	1.3	0.7	0.4	0.8	0.2	1.3	1.1	0.8	0.9	0.6	0.8
+ 04744: Phototransduction	0.6	1.4	0.4	0.4	0	0.1	0.4	1.8	0.5	1	0	0.2
RHO	V							V		V
CNGA1		V		V		V
GRK1		V					V		V
RCVRN			V
CNGB1								V		V
GUCA1B								V		V
GNAT2									V
GNB1										V		V
+ 04740: Olfactory transduction	0.1	0	0	0	0	0	0	0.1	0	0	0.1	0
OR4N4	V							V
OR51L1	V							V		V
OR51S1	V				V
OR2T12	V		V				V					V
OR52I2	V
OR5J2	V		V		V
OR2T8	V		V				V					V
OR10A6	V							V
OR2T33	V		V				V					V
OR5P2		V		V		V
OR13H1		V		V				V			V
OR52A5		V
OR10P1			V				V
OR4S1			V		V		V		V		V
OR51Q1			V									V
OR4X1			V				V					V
ANO2			V		V				V
PDE2A			V		V		V		V		V
RGS2			V		V		V		V
OR56A3				V				V			V
PRKACB				V		V		V		V		V
OR4S2					V				V		V
OR13J1					V
OR9K2					V				V
PDE1C					V				V		V
OR5P3						V				V		V
OR11H6						V				V
OR7E24						V						V
OR4C12						V				V		V
OR6X1						V
CAMK2B						V		V		V
OR6P1							V		V
OR7G3							V		V
OR6B3								V
OR7G2								V
CNGB1								V		V
OR2B6									V
OR52N4									V
OR10K2									V
OR2AK2									V		V
OR13A1									V
GNB1										V		V
OR5I1										V
OR52R1										V
OR10A7										V
OR14A16										V
OR13D1										V
OR6S1										V
GRK3										V
OR2L13											V
OR5D13											V
OR2V2												V
+ 04742: Taste transduction	0.1	0.8	0	0	0.3	0.2	0.4	0.1	0.3	0.1	0.7	1.3
TRPM5	V		V			V				V		V
SCN3A		V				V	V			V		V
SCNN1A		V				V	V					V
TAS2R20		V					V					V
PRKACB				V		V		V		V		V
SCN9A					V				V		V
PDE1C					V				V		V
GABBR2					V
GNB3					V				V		V
HTR1D						V
GNAT3						V				V		V
GRM4									V
HTR1B									V
ITPR3										V
TAS2R16												V
HTR3A												V
+ 04750: Inflammatory mediator regulation of TRP channels	1.3	0.3	1.1	0.3	1.3	0.1	1.8	0.4	0.7	0.7	0.5	0.1
BDKRB2	V									V
PTGER4	V				V
PLA2G4A	V		V		V		V		V
IGF1	V		V		V
PRKCB	V							V
BDKRB1		V			V				V		V
MAP2K6		V					V
IL1B			V		V		V		V
PLCB1			V				V					V
PLCG2			V
CYP2J2			V		V		V		V
NGF				V		V				V
PRKACB				V		V		V		V		V
PPP1CB				V		V				V
PLA2G4C					V				V		V
TRPV2					V				V		V
PRKCH					V				V
IL1R1						V				V		V
CAMK2B						V		V		V
PIK3CA						V				V
PTGER2							V
IL1RAP							V
PRKCE							V					V
ADCY1									V
ALOX12										V
ADCY5										V
PRKCD										V
ITPR3										V
+ 5.8 Development and regeneration	1.3	1.6	1.9	1.8	2.3	2.3	1.8	2.6	1.3	2.1	1	1.3
+ 04360: Axon guidance	0.5	1.5	0.2	2.5	1.7	3.1	1.3	2.7	1.8	1.9	0.9	0.7
CXCR4	V				V			V			V
SLIT2	V				V						V
EPHB1	V									V
EPHB3	V							V		V
SEMA6D	V		V		V				V
PARD6B		V		V		V				V		V
ROBO1		V		V		V				V
SEMA3A		V			V		V		V		V
SEMA3B		V		V		V	V
SEMA4G		V					V		V
SEMA5A		V		V		V		V		V
L1CAM		V		V		V				V
MYL5		V					V		V
PARD6G			V				V					V
DCC			V		V		V		V
PLXNA2			V		V		V
PLCG2			V
NEO1			V		V		V		V
ROCK1				V		V
ROCK2				V		V				V		V
PAK6				V		V				V		V
RASA1				V		V		V		V
EPHB4				V				V
PLXNA3				V
SEMA3C				V		V		V
SEMA4B				V		V		V		V
BMPR2				V		V		V		V		V
PARD6A					V		V		V
NTN4					V				V		V
EPHA4					V				V		V
ROBO2					V
EFNB1					V				V		V
RGS3					V	V			V	V		V
SEMA3F					V		V		V
BMPR1B					V				V
TRPC6					V
WNT5B					V				V		V
PPP3CA						V						V
PAK2						V				V
MET						V		V		V
PLXNC1						V
PLXNB1						V				V
PLXNA1						V
SEMA4D						V
NCK2						V				V		V
NRAS						V				V		V
LIMK1						V
CAMK2B						V		V		V
TRPC1						V				V
PIK3CA						V				V
PDK1						V				V		V
RHOD						V
CFL1						V				V		V
CFL2						V		V		V
SSH3						V
SEMA6B							V		V
FYN								V
NRP1								V
CXCL12								V		V
ROBO3									V
UNC5B									V
EPHB2									V
EFNA3									V
GNAI3										V
RAC1										V		V
SRGAP2												V
+ 04380: Osteoclast differentiation	1.3	0.7	2.5	0	1.5	0.2	1.3	1	0.1	1.1	0.5	1.1
MAP3K14	V
RELA	V		V		V
AKT2	V		V							V		V
TNF	V							V		V
NFKB2	V									V
NCF2	V		V		V			V
CSF1R		V				V						V
MAP2K6		V					V
PPARG		V
NCF1		V					V
TNFRSF11A			V		V		V		V
IL1A			V		V
IL1B			V		V		V		V
JUNB			V		V
FCGR2A			V				V			V		V
FCGR2C			V				V			V		V
PLCG2			V
SQSTM1			V		V
LILRA1			V				V
AKT3				V		V		V		V	V
TGFB2				V		V				V
GAB2					V				V
TYK2					V						V
FOS					V				V		V
FOSB					V
OSCAR					V				V
CSF1						V						V
PIK3CA						V				V
IL1R1						V				V		V
PPP3CA						V						V
CREB1						V				V
SOCS1						V
TGFBR1						V				V		V
SOCS3							V		V
TAB2								V		V
FYN								V
LILRA3								V		V
CHUK										V
MAP3K7										V		V
RAC1										V		V
MITF											V
NFKBIA												V
+ 5.9 Aging	3.1	0.1	1.1	1.3	0.7	2.5	0.3	2.7	0.3	3.4	0.5	1.1
+ 04211: Longevity regulating pathway	2.4	0.1	0.9	1.1	0.4	1.9	0.1	2	0	2.3	0.3	1.1
AKT2	V		V							V		V
IGF1	V		V		V
IRS2	V				V			V			V
CREB5	V		V							V
SOD2	V									V
KL	V							V
RELA	V		V		V
PPARG		V
CREB3L3			V				V					V
AKT3				V		V		V		V	V
PRKACB				V		V		V		V		V
PRKAA2				V		V				V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
SESN2					V
ADIPOR2					V
RPS6KB1						V				V
PIK3CA						V				V
IRS1						V
NRAS						V				V		V
PRKAA1						V		V		V
CREB1						V				V
CREB3L1						V				V
APPL1						V				V		V
RB1CC1						V
ATF4							V
RPTOR									V
ADCY1									V
EIF4E									V
ADCY5										V
+ 04213: Longevity regulating pathway - multiple species	2.1	0	0.6	0.8	0.5	1.7	0.3	1.8	0.4	2.5	0.5	0.5
AKT2	V		V							V		V
IGF1	V		V		V
IRS2	V				V			V			V
SOD2	V									V
HSPA1B	V							V		V
FOXA2			V		V		V		V
AKT3				V		V		V		V	V
PRKACB				V		V		V		V		V
PRKAA2				V		V				V		V
CLPB					V		V		V
RPS6KB1						V				V
PIK3CA						V				V
IRS1						V
NRAS						V				V		V
PRKAA1						V		V		V
CRYAB						V				V
HSPA1A						V				V
RPTOR									V
ADCY1									V
ADCY5										V
+ 5.10 Environmental adaptation	1.1	0	0.5	0.9	0.5	1.4	0.4	1.7	0.5	1.6	1.5	0.4
+ 04710: Circadian rhythm	0	0	0.3	1	0.5	2.2	0.3	0.4	0.4	1.7	1.1	0.5
BHLHE41			V		V		V		V
CLOCK				V		V				V
PRKAA2				V		V				V		V
PER1					V				V		V
NPAS2						V				V		V
PER3						V
FBXL3						V				V
PRKAA1						V		V		V
CREB1						V				V
NR1D1											V
+ 04713: Circadian entrainment	1.8	0	0	0	0.3	0.1	0.1	2.3	0.2	0.8	1.2	0.1
NOS1	V							V		V
GUCY1A1	V										V
PRKCB	V							V
GNGT2	V							V		V
CACNA1H	V
CACNA1G	V							V
PLCB1			V				V					V
PRKACB				V		V		V		V		V
GNB3					V				V		V
GNG5					V
RASD1					V		V		V		V
PER1					V				V		V
FOS					V				V		V
CAMK2B						V		V		V
GNG10						V						V
GNB4						V
CREB1						V				V
PER3						V
GRIA4								V
RPS6KA5								V		V
ADCY1									V
GNB1										V		V
GNG4										V
ITPR3										V
ADCY5										V
GNAI3										V
+ 04714: Thermogenesis	0	0.1	0.5	0.6	0.1	0	0.2	0.3	0.2	0.4	0.2	0.1
CREB5	V		V							V
ARID1B	V									V
COX7B2	V		V		V		V		V		V
PPARG		V
RPS6KA2		V				V				V		V
NPPB		V					V		V
CREB3L3			V				V					V
CPT1A			V		V		V
UQCRHL			V
NDUFA9			V		V				V
NDUFC2			V
COA1			V									V
UQCRH			V
ATP5MC1			V		V		V		V
CREB3L2				V		V		V		V		V
PRKACB				V		V		V		V		V
ATF2				V		V		V		V		V
DPF3				V							V
RPS6KA3				V		V				V		V
SOS1				V		V				V
ACSL3				V		V		V		V
ACSL4				V		V		V		V
PRKAA2				V		V				V		V
DPF1					V				V		V
SLC25A29					V						V
SLC25A20					V
UQCRQ					V
NDUFB9					V
ATP5F1D					V				V		V
CREB1						V				V
CREB3L1						V				V
RPS6KB1						V				V
FRS2						V				V
NRAS						V				V		V
PRKAA1						V		V		V
NDUFA5						V				V		V
NDUFAF3							V
COX18							V		V
COA4							V		V
ACSL6								V		V
ADCY1									V
ZNF516									V
RPTOR									V
NDUFA3									V
NDUFB1									V
ADCY5										V
SOS2										V
COX7A2										V		V
+ 6. Human Diseases	6.2	1.8	5.7	3.9	4.6	7.1	4.1	6.5	3.8	8.7	6.3	4.5
+ 6.1 Cancer: overview	4	1.2	3.3	1.9	3.9	3.9	2.3	4.3	2.7	4.6	4.7	2.9
+ 05200: Pathways in cancer	1.7	0.4	1.4	0.1	1.5	1.3	1.8	1.6	1.2	2	2.2	0.8
WNT11	V			V				V		V
LAMA4	V							V		V
LAMC2	V		V		V
IGF1	V		V		V
NFKB2	V									V
RELA	V		V		V
PRKCB	V							V
CDKN1A	V							V
CDK6	V					V		V		V
SKP2	V		V							V		V
CASP8	V		V							V		V
TRAF1	V		V		V
MMP1	V		V		V		V		V
AKT2	V		V							V		V
FGF1	V				V
LPAR5	V
PTGER4	V				V
BDKRB2	V									V
GNGT2	V							V		V
CXCR4	V				V			V			V
IL23A	V		V							V
IL2RG	V				V
COL4A4		V				V	V
COL4A5		V					V
LAMA5		V				V	V
TPR		V		V		V
TCF7		V					V		V
PPARG		V
CCNA1		V					V		V
VEGFB		V
CSF1R		V				V						V
EDNRA		V		V		V
BDKRB1		V			V				V		V
LRP5		V					V
IL7R		V			V		V		V		V
DCC			V		V		V		V
COL4A6			V				V
TGFA			V		V		V		V			V
PLCG2			V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
RARB			V		V		V		V		V
CCND2			V		V		V		V		V
CKS1B			V							V		V
BMP2			V		V				V		V
PTGS2			V		V		V		V		V
MMP9			V				V					V
CXCL8			V
PLCB1			V				V					V
KIF7			V		V
MGST2			V				V		V
IL7			V		V		V		V
IL6R			V		V		V		V
IL15RA			V
PTEN				V		V
SOS1				V		V				V
HIF1A				V		V		V		V
ARNT2				V		V		V		V		V
TGFB2				V		V				V
BMP4				V		V		V		V
AKT3				V		V		V		V	V
EDNRB				V		V		V		V		V
PRKACB				V		V		V		V		V
ROCK1				V		V
ROCK2				V		V				V		V
POLK				V		V		V		V		V
WNT5B					V				V		V
FN1					V				V		V
LAMA2					V				V		V
FZD4					V				V		V
FOS					V				V		V
PGF					V				V		V
DAPK3					V				V		V
GLI3					V
LPAR1					V				V		V
GNB3					V				V		V
GNG5					V
JAG1					V				V
HEY1					V				V		V
HEYL					V				V		V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
GADD45B					V						V
FRAT1					V				V
EDN1					V				V		V
CDH1						V				V		V
ITGA6						V		V		V		V
ITGAV						V				V		V
FZD6						V				V
FZD7						V		V		V
APPL1						V				V		V
PIK3CA						V				V
MET						V		V		V
NRAS						V				V		V
BRAF						V				V
PLD1						V				V
EGLN1						V
CUL2						V
EPAS1						V				V		V
TGFBR1						V				V		V
SMAD2						V				V		V
SMAD3						V
MECOM						V
JUP						V				V
RB1						V				V
CCNE2						V				V
XIAP						V				V
VEGFA						V				V		V
SLC2A1						V						V
DAPK2						V		V		V
GLI2						V		V		V
KITLG						V
F2R						V				V		V
GNG10						V						V
GNB4						V
GNA13						V				V		V
NFE2L2						V				V		V
GSTM2						V				V		V
GSTM4						V		V		V
RPS6KB1						V				V
CAMK2B						V		V		V
BCL2L11						V				V		V
PIM1						V
IL15						V
CSF2RB						V				V
IL6ST						V
RASSF5							V
PTGER2							V
GSTA3							V
GSTA4							V		V
IFNA4							V
IFNA16							V
IFNA17							V
IFNA21							V
IL12A							V
HSP90AA1								V
CXCL12								V		V
TXNRD1								V		V
RPS6KA5								V		V
WNT10B									V
FGFR2									V
IGF2									V
APC2									V
RET									V
HHIP									V
FGF5									V
ADCY1									V
TXNRD2									V
LRP6									V
FRAT2									V
WNT2										V
FLT3										V
CHUK										V
SOS2										V
RALB										V
RAC1										V		V
ADCY5										V
GNB1										V		V
GNG4										V
GNAI3										V
NOTCH2										V		V
NCOA1										V
PMAIP1										V
IL12B										V
MITF											V
ITGA2												V
NFKBIA												V
EGLN3												V
BIRC3												V
IL6												V
+ 05202: Transcriptional misregulation in cancer	2.9	1.5	2.1	1.3	2.1	1.4	1.8	2.7	0.9	0.3	1.7	0.7
SSX1	V							V
SSX2	V							V
SSX2B	V							V
ID2	V		V		V		V		V
NUPR1	V							V			V
CDKN1A	V							V
IGF1	V		V		V
TMPRSS2	V							V		V
TRAF1	V		V		V
HMGA2	V				V			V		V
NGFR	V					V				V		V
MPO	V							V
RELA	V		V		V
PPARG		V
CCNA1		V					V		V
CD14		V		V		V
PBX1		V		V		V				V
CDK14		V					V		V
MAF		V					V					V
CSF1R		V				V						V
NSD2		V					V		V
MYC			V				V
NFKBIZ			V
CXCL8			V
MMP3			V		V		V		V		V
MMP9			V				V					V
BCL2A1			V		V		V		V		V
LMO2			V		V		V		V
SMAD1			V		V		V		V
MEF2C			V		V				V
CCND2			V		V		V		V		V
WT1				V		V		V		V		V
ARNT2				V		V		V		V		V
ELK4				V		V				V
ZEB1				V		V		V		V
JMJD1C				V		V				V
SIX4				V				V
PLAT				V		V
POLK				V		V		V		V		V
ERG					V				V		V
DDIT3					V
ASPSCR1					V
IGFBP3					V				V		V
CEBPB					V
MEIS1					V				V		V
H3F3B					V
GADD45B					V						V
ETV1						V				V
ATF1						V				V
ATM						V
MET						V		V		V
JUP						V				V
CD40						V				V		V
RUNX2						V				V
UTY						V
COMMD3-BMI1						V
BMI1						V
CCNT2						V
HPGD						V						V
PAX3							V
BMP2K									V
HIST1H3H									V
FLT3										V
SIX1											V
MITF											V
FUS												V
SS18												V
IL6												V
BIRC3												V
+ 05206: MicroRNAs in cancer	1.7	0.3	2.1	1.5	1.3	3.5	1.5	2.6	0.6	2.3	0.6	1.2
CDK6	V					V		V		V
HMGA2	V				V			V		V
CYP24A1	V		V		V
IRS2	V				V			V			V
CDKN1A	V							V
TNXB	V							V
TRIM71	V		V		V
PRKCB	V							V
DDIT4		V		V		V	V					V
TNC		V	V		V		V		V
BMF		V
CDC25A			V
MMP9			V				V					V
CCND2			V		V		V		V		V
SERPINB5			V		V		V		V			V
MYC			V				V
ZFPM2			V		V		V		V
SOX4			V		V				V
PTGS2			V		V		V		V		V
PLCG2			V
PTEN				V		V
ZEB1				V		V		V		V
TGFB2				V		V				V
CCNG1				V		V
ROCK1				V		V
BMPR2				V		V		V		V		V
DICER1				V		V				V
SOS1				V		V				V
DNMT3B					V				V
ERBB3					V						V
MMP16					V				V		V
VEGFA						V				V		V
CYP1B1						V		V		V		V
PDCD4						V
MET						V		V		V
CCNE2						V				V
PIM1						V
TIMP3						V				V		V
NRAS						V				V		V
IRS1						V
PIK3CA						V				V
COMMD3-BMI1						V
BMI1						V
RECK						V				V
BCL2L11						V				V		V
MARCKS						V				V
GLS						V		V		V		V
ATM						V
SOCS1						V
THBS1						V				V		V
DNMT3A							V
PRKCE							V					V
RPS6KA5								V		V
RPTOR									V
APC2									V
EFNA3									V
NOTCH2										V		V
CD44										V
BRCA1										V
SOS2										V
+ 05205: Proteoglycans in cancer	1.1	0.1	0.1	1.1	0.1	2.8	0.1	2.2	0.7	3.7	0.5	1.2
ANK2	V	V					V	V	V
AKT2	V		V							V		V
HCLS1	V							V
TNF	V							V		V
CDKN1A	V							V
IGF1	V		V		V
PRKCB	V							V
WNT11	V			V				V		V
HPSE		V				V	V
SDC2		V				V	V					V
MMP9			V				V					V
MYC			V				V
PLCG2			V
ROCK1				V		V
ROCK2				V		V				V		V
AKT3				V		V		V		V	V
PPP1CB				V		V				V
HIF1A				V		V		V		V
TGFB2				V		V				V
SOS1				V		V				V
PRKACB				V		V		V		V		V
CAV2				V		V				V		V
ANK3					V				V		V
PLAUR					V
TLR4					V				V
ERBB3					V						V
FZD4					V				V		V
FN1					V				V		V
KDR					V				V
WNT5B					V				V		V
TIAM1						V				V		V
ANK1						V
PIK3CA						V				V
PPP1R12A						V
CAMK2B						V		V		V
NRAS						V				V		V
BRAF						V				V
SMAD2						V				V		V
TLR2						V				V		V
PDCD4						V
MET						V		V		V
TIMP3						V				V		V
THBS1						V				V		V
VEGFA						V				V		V
RPS6KB1						V				V
ITGAV						V				V		V
FZD6						V				V
FZD7						V		V		V
FRS2						V				V
GPC1						V				V		V
CAV1						V
LUM								V		V
PPP1R12B									V
PLCE1									V
NANOG									V
NUDT16L1									V
IGF2									V
TWIST2									V
TWIST1									V
WNT10B									V
CD44										V
ITPR3										V
GAB1										V
RAC1										V		V
IQGAP1										V
VAV2										V
IL12B										V
SOS2										V
WNT2										V
ITGA2												V
+ 05204: Chemical carcinogenesis	1.2	0.9	1.8	0	2	0.1	0.7	0.6	1.8	0.5	2.4	1.6
CYP1A1	V		V		V				V
UGT2A1	V		V							V		V
UGT2A2	V		V							V		V
HSD11B1	V							V		V
CYP1A2		V		V		V
ALDH3B1		V
EPHX1		V				V
UGT2B11			V		V
UGT2B28			V		V				V		V
MGST2			V				V		V
PTGS2			V		V		V		V		V
UGT2B7					V				V		V
UGT2B10					V				V		V
ALDH1A3					V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
GSTM2						V				V		V
GSTM4						V		V		V
CYP1B1						V		V		V		V
GSTA3							V
GSTA4							V		V
ADH6										V		V
AKR1C2										V
SULT1A4												V
SULT1A3												V
SULT1A2												V
SULT1A1												V
+ 05203: Viral carcinogenesis	2	0	1.3	0.2	3.6	0.5	0.1	1.6	2.3	2	4.9	1.2
TBP	V		V							V		V
CASP8	V		V							V		V
TRAF1	V		V		V
CREB5	V		V							V
NFKB2	V									V
RELA	V		V		V
CDK6	V					V		V		V
SKP2	V		V							V		V
CDKN1A	V							V
HDAC9	V							V		V
HIST2H2BF	V				V				V	V	V
CCNA1		V					V		V
CREB3L3			V				V					V
CCND2			V		V		V		V		V
SCIN			V
SP100			V									V
HIST1H2BD			V		V				V		V
HIST1H2BB			V		V						V
DLG1				V		V		V		V
ATF2				V		V		V		V		V
CREB3L2				V		V		V		V		V
RBPJ				V		V
PRKACB				V		V		V		V		V
HIST3H2BB				V	V			V			V
EGR2					V				V		V
MAD1L1					V				V
UBR4					V
LTBR					V		V		V
HIST1H2BF					V						V
HIST1H2BE					V				V		V
HIST1H2BI					V				V		V
HIST1H2BC					V				V		V
HIST1H2BL					V				V		V
HIST1H2BN					V				V		V
HIST1H2BM					V				V		V
HIST1H2BH					V						V
HIST1H2BO					V				V		V
HIST2H2BE					V				V		V
HIST1H2BK					V				V		V
HIST1H2BJ					V				V		V
HIST4H4					V				V		V
HIST2H4B					V				V		V
HIST1H4H					V				V		V
HIST2H4A					V				V		V
RB1						V				V
CREB1						V				V
CREB3L1						V				V
PIK3CA						V				V
KAT2B						V				V
CCNE2						V				V
NRAS						V				V		V
RASA2						V		V		V
IL6ST						V
C3						V						V
HLA-F						V				V		V
DDX3X						V		V		V
CDK1						V				V		V
ATF4							V
CCNA2							V					V
RBL1								V
CCR8									V
HIST1H4E									V
PMAIP1										V
RAC1										V		V
GSN										V
HLA-B										V
HLA-C										V		V
EIF2AK2										V		V
NFKBIA												V
+ 05230: Central carbon metabolism in cancer	0.2	0	0.5	0.6	0	1.1	0.1	1.2	0.1	1.3	0.1	1
AKT2	V		V							V		V
MYC			V				V
SIRT3			V									V
HIF1A				V		V		V		V
AKT3				V		V		V		V	V
PTEN				V		V
TIGAR					V
SLC2A1						V						V
GLS						V		V		V		V
PDK1						V				V		V
MET						V		V		V
NRAS						V				V		V
PIK3CA						V				V
FGFR2									V
RET									V
SCO2									V
FLT3										V
G6PD										V
+ 05231: Choline metabolism in cancer	0.6	0	0.4	0.3	0.5	0.4	0.5	0.4	0.3	1.2	1.2	0.2
AKT2	V		V							V		V
PLA2G4A	V		V		V		V		V
PRKCB	V							V
PDGFD			V		V		V		V
DGKK			V
SOS1				V		V				V
AKT3				V		V		V		V	V
HIF1A				V		V		V		V
PLA2G4C					V				V		V
DGKA					V
WASF3					V		V		V
FOS					V				V		V
NRAS						V				V		V
PIK3CA						V				V
PDGFC						V
CHPT1						V	V					V
PLD1						V				V
RPS6KB1						V				V
SLC22A3									V		V
SOS2										V
SLC44A1										V		V
LYPLA1										V
RAC1										V		V
WASF1										V
PLPP3											V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	0.7	0.4	0.3	0.4	0.6	0.6	0.3	0.2	0.1	0.5	0.6	0.8
RELA	V		V		V
AKT2	V		V							V		V
MAP3K3	V				V
CD3D		V	V		V		V		V			V
MAP2K6		V					V
AKT3				V		V		V		V	V
PTEN				V		V
HIF1A				V		V		V		V
NFKBIB					V				V		V
FOS					V				V		V
TLR4					V				V
PIK3CA						V				V
NRAS						V				V		V
PPP3CA						V						V
TLR2						V				V		V
BATF						V				V		V
RPS6KB1						V				V
BATF2							V
CHUK										V
NFKBIA												V
+ 6.2 Cancer: specific types	4.7	1.3	4.4	3.2	2.1	6.2	3.8	5.3	2.4	7.5	4.5	3.3
+ 05210: Colorectal cancer	0.3	0.4	1.7	0.8	0.7	1.7	2.1	0.5	1	2.7	1.4	1.8
AKT2	V		V							V		V
CDKN1A	V							V
TCF7		V					V		V
AREG		V					V		V
DCC			V		V		V		V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
TGFA			V		V		V		V			V
EREG			V		V		V		V		V
TGFB2				V		V				V
AKT3				V		V		V		V	V
POLK				V		V		V		V		V
SOS1				V		V				V
FOS					V				V		V
GADD45B					V						V
PIK3CA						V				V
APPL1						V				V		V
SMAD2						V				V		V
SMAD3						V
TGFBR1						V				V		V
BRAF						V				V
BCL2L11						V				V		V
NRAS						V				V		V
RPS6KB1						V				V
APC2									V
RAC1										V		V
PMAIP1										V
RALB										V
SOS2										V
+ 05212: Pancreatic cancer	1.3	0	0.4	0.6	0.2	2.1	0	1.1	0	2.9	0.4	1.1
AKT2	V		V							V		V
RELA	V		V		V
CDK6	V					V		V		V
CDKN1A	V							V
TGFA			V		V		V		V			V
AKT3				V		V		V		V	V
TGFB2				V		V				V
POLK				V		V		V		V		V
GADD45B					V						V
PIK3CA						V				V
BRAF						V				V
PLD1						V				V
VEGFA						V				V		V
RB1						V				V
TGFBR1						V				V		V
SMAD2						V				V		V
SMAD3						V
RPS6KB1						V				V
RAC1										V		V
CHUK										V
RALB										V
+ 05225: Hepatocellular carcinoma	0.9	0.1	0.5	1	0.6	2	1	2	2.1	2.4	2.3	0.2
AKT2	V		V							V		V
WNT11	V			V				V		V
CDKN1A	V							V
PRKCB	V							V
ARID1B	V									V
CDK6	V					V		V		V
TCF7		V					V		V
LRP5		V					V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
TGFA			V		V		V		V			V
PLCG2			V
MGST2			V				V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
PTEN				V		V
POLK				V		V		V		V		V
TGFB2				V		V				V
DPF3				V							V
PBRM1				V		V		V
SHC3					V				V		V
FRAT1					V				V
FZD4					V				V		V
WNT5B					V				V		V
GADD45B					V						V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
DPF1					V				V		V
NRAS						V				V		V
BRAF						V				V
SHC2						V
RPS6KB1						V				V
PIK3CA						V				V
FZD6						V				V
FZD7						V		V		V
RB1						V				V
SMAD2						V				V		V
SMAD3						V
TGFBR1						V				V		V
MET						V		V		V
ARID2						V				V
NFE2L2						V				V		V
GSTM2						V				V		V
GSTM4						V		V		V
PHF10						V				V
GSTA3							V
GSTA4							V		V
TXNRD1								V		V
IGF2									V
APC2									V
FRAT2									V
LRP6									V
WNT10B									V
TXNRD2									V
SOS2										V
WNT2										V
GAB1										V
+ 05226: Gastric cancer	0.4	0.1	0.3	0.4	0.3	1.4	0.5	0.8	1.1	1.9	1.3	0.1
AKT2	V		V							V		V
WNT11	V			V				V		V
CDKN1A	V							V
FGF1	V				V
TCF7		V					V		V
LRP5		V					V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
RARB			V		V		V		V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
POLK				V		V		V		V		V
TGFB2				V		V				V
SHC3					V				V		V
FRAT1					V				V
FZD4					V				V		V
WNT5B					V				V		V
GADD45B					V						V
NRAS						V				V		V
BRAF						V				V
SHC2						V
RPS6KB1						V				V
PIK3CA						V				V
FZD6						V				V
FZD7						V		V		V
SMAD2						V				V		V
SMAD3						V
TGFBR1						V				V		V
MET						V		V		V
CDH1						V				V		V
JUP						V				V
CCNE2						V				V
RB1						V				V
APC2									V
FRAT2									V
LRP6									V
WNT10B									V
FGFR2									V
FGF5									V
SOS2										V
WNT2										V
GAB1										V
+ 05214: Glioma	1.8	0	0.8	0.9	0.3	1.5	0	1.9	0	1.4	0.8	0.3
IGF1	V		V		V
PRKCB	V							V
AKT2	V		V							V		V
CDK6	V					V		V		V
CDKN1A	V							V
TGFA			V		V		V		V			V
PLCG2			V
SOS1				V		V				V
AKT3				V		V		V		V	V
PTEN				V		V
POLK				V		V		V		V		V
SHC3					V				V		V
GADD45B					V						V
CAMK2B						V		V		V
SHC2						V
BRAF						V				V
PIK3CA						V				V
RB1						V				V
NRAS						V				V		V
SOS2										V
+ 05216: Thyroid cancer	0.4	1.8	1.2	0.8	0.4	1	1.7	0.9	0.6	0.6	0.9	1.2
CDKN1A	V							V
PPARG		V
TPR		V		V		V
TCF7		V					V		V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
POLK				V		V		V		V		V
GADD45B					V						V
NRAS						V				V		V
BRAF						V				V
CDH1						V				V		V
RET									V
+ 05221: Acute myeloid leukemia	1	1.6	1.8	0.7	0.2	1.5	1.8	0.4	0.4	1.7	0.9	0.4
RELA	V		V		V
AKT2	V		V							V		V
MPO	V							V
CCNA1		V					V		V
TCF7		V					V		V
CD14		V		V		V
CSF1R		V				V						V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
BCL2A1			V		V		V		V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
NRAS						V				V		V
JUP						V				V
PIM1						V
RPS6KB1						V				V
PIK3CA						V				V
BRAF						V				V
FLT3										V
CHUK										V
SOS2										V
+ 05220: Chronic myeloid leukemia	1.3	0	0.4	0.9	0.3	2.1	0	1	0	1.9	0.7	0.5
RELA	V		V		V
CDKN1A	V							V
CDK6	V					V		V		V
AKT2	V		V							V		V
MYC			V				V
TGFB2				V		V				V
SOS1				V		V				V
AKT3				V		V		V		V	V
POLK				V		V		V		V		V
SHC3					V				V		V
GAB2					V				V
GADD45B					V						V
MECOM						V
TGFBR1						V				V		V
SHC2						V
RB1						V				V
SMAD3						V
PIK3CA						V				V
BRAF						V				V
NRAS						V				V		V
CHUK										V
SOS2										V
NFKBIA												V
+ 05217: Basal cell carcinoma	0.6	0.2	1	0.7	1.6	0.3	0.6	2.2	1.7	0.7	1.9	0.1
WNT11	V			V				V		V
CDKN1A	V							V
TCF7		V					V		V
KIF7			V		V
BMP2			V		V				V		V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
BMP4				V		V		V		V
POLK				V		V		V		V		V
WNT5B					V				V		V
FZD4					V				V		V
GLI3					V
GADD45B					V						V
FZD6						V				V
FZD7						V		V		V
GLI2						V		V		V
WNT10B									V
APC2									V
HHIP									V
WNT2										V
+ 05218: Melanoma	1.8	0	0.5	0.6	0.4	1.6	0	1.6	0	1.2	0.8	0.3
FGF1	V				V
IGF1	V		V		V
CDKN1A	V							V
CDK6	V					V		V		V
AKT2	V		V							V		V
PDGFD			V		V		V		V
PTEN				V		V
AKT3				V		V		V		V	V
POLK				V		V		V		V		V
GADD45B					V						V
BRAF						V				V
CDH1						V				V		V
NRAS						V				V		V
MET						V		V		V
PDGFC						V
RB1						V				V
PIK3CA						V				V
FGF5									V
MITF											V
+ 05211: Renal cell carcinoma	0.5	0	0.2	1.9	0	3.3	0.1	1.6	0	3.7	0.1	2.4
AKT2	V		V							V		V
CDKN1A	V							V
TGFA			V		V		V		V			V
TGFB2				V		V				V
ARNT2				V		V		V		V		V
HIF1A				V		V		V		V
SOS1				V		V				V
PAK6				V		V				V		V
AKT3				V		V		V		V	V
VEGFA						V				V		V
SLC2A1						V						V
CUL2						V
EGLN1						V
EPAS1						V				V		V
MET						V		V		V
PAK2						V				V
PIK3CA						V				V
BRAF						V				V
NRAS						V				V		V
FLCN									V
RAC1										V		V
SOS2										V
GAB1										V
RAP1A										V
EGLN3												V
+ 05219: Bladder cancer	0.9	0	1.6	0	0.3	1.6	1.1	1.3	0.2	1.9	0.3	1.4
MMP1	V		V		V		V		V
CDKN1A	V							V
MMP9			V				V					V
CXCL8			V
MYC			V				V
DAPK3					V				V		V
VEGFA						V				V		V
THBS1						V				V		V
CDH1						V				V		V
DAPK2						V		V		V
RB1						V				V
BRAF						V				V
NRAS						V				V		V
RPS6KA5								V		V
+ 05215: Prostate cancer	1.8	0.1	2.9	1.3	0.8	1.6	2.2	1.5	0.6	2	0.9	0.9
RELA	V		V		V
CDKN1A	V							V
CREB5	V		V							V
IGF1	V		V		V
AKT2	V		V							V		V
TMPRSS2	V							V		V
TCF7		V					V		V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
CREB3L3			V				V					V
TGFA			V		V		V		V			V
PDGFD			V		V		V		V
MMP3			V		V		V		V		V
MMP9			V				V					V
PTEN				V		V
CREB3L2				V		V		V		V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
ZEB1				V		V		V		V
PLAT				V		V
ERG					V				V		V
NRAS						V				V		V
CREB1						V				V
CREB3L1						V				V
CCNE2						V				V
PDGFC						V
RB1						V				V
PIK3CA						V				V
BRAF						V				V
ATF4							V
HSP90AA1								V
FGFR2									V
CHUK										V
SOS2										V
NFKBIA												V
+ 05213: Endometrial cancer	0.6	0.3	1.1	1.3	0.1	1.2	1.1	0.9	0.2	1.4	1	0.9
AKT2	V		V							V		V
CDKN1A	V							V
TCF7		V					V		V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
MYC			V				V
PTEN				V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
POLK				V		V		V		V		V
GADD45B					V						V
NRAS						V				V		V
CDH1						V				V		V
PIK3CA						V				V
BRAF						V				V
APC2									V
SOS2										V
+ 05224: Breast cancer	1.4	0.1	0.3	0.4	1.1	0.4	0.3	0.8	1.5	1.3	1.9	0.1
IGF1	V		V		V
AKT2	V		V							V		V
WNT11	V			V				V		V
CDK6	V					V		V		V
CDKN1A	V							V
NFKB2	V									V
FGF1	V				V
TCF7		V					V		V
LRP5		V					V
MYC			V				V
LEF1			V		V		V		V		V
TCF7L1			V				V					V
SOS1				V		V				V
AKT3				V		V		V		V	V
PTEN				V		V
POLK				V		V		V		V		V
SHC3					V				V		V
JAG1					V				V
FOS					V				V		V
FRAT1					V				V
FZD4					V				V		V
WNT5B					V				V		V
HEY1					V				V		V
HEYL					V				V		V
GADD45B					V						V
NRAS						V				V		V
BRAF						V				V
SHC2						V
RPS6KB1						V				V
PIK3CA						V				V
FZD6						V				V
FZD7						V		V		V
RB1						V				V
APC2									V
FRAT2									V
LRP6									V
WNT10B									V
FGF5									V
NCOA1										V
SOS2										V
NOTCH2										V		V
WNT2										V
BRCA1										V
PGR												V
+ 05222: Small cell lung cancer	2.7	0.7	2.6	0.4	1.1	1.3	1.9	1.6	0.2	1.6	1.7	1.3
AKT2	V		V							V		V
LAMA4	V							V		V
LAMC2	V		V		V
TRAF1	V		V		V
CDK6	V					V		V		V
RELA	V		V		V
SKP2	V		V							V		V
CDKN1A	V							V
COL4A4		V				V	V
COL4A5		V					V
LAMA5		V				V	V
RARB			V		V		V		V		V
CKS1B			V							V		V
MYC			V				V
COL4A6			V				V
PTGS2			V		V		V		V		V
AKT3				V		V		V		V	V
PTEN				V		V
POLK				V		V		V		V		V
FN1					V				V		V
LAMA2					V				V		V
GADD45B					V						V
CCNE2						V				V
ITGA6						V		V		V		V
ITGAV						V				V		V
PIK3CA						V				V
XIAP						V				V
RB1						V				V
FHIT							V		V
CHUK										V
ITGA2												V
BIRC3												V
NFKBIA												V
+ 05223: Non-small cell lung cancer	1.5	0	0.9	0.7	0.2	0.9	1	1.7	0.2	1.4	0.9	0.4
PRKCB	V							V
AKT2	V		V							V		V
CDK6	V					V		V		V
CDKN1A	V							V
PLCG2			V
TGFA			V		V		V		V			V
RARB			V		V		V		V		V
AKT3				V		V		V		V	V
SOS1				V		V				V
POLK				V		V		V		V		V
GADD45B					V						V
PIK3CA						V				V
NRAS						V				V		V
RB1						V				V
BRAF						V				V
RASSF5							V
FHIT							V		V
SOS2										V
+ 6.12 Drug resistance: antineoplastic	2.1	0.6	2.2	1.6	1.9	2.2	1	1.7	1.5	3	1.7	1.6
+ 01521: EGFR tyrosine kinase inhibitor resistance	0.8	0	1.9	0.9	1.5	2	0.7	0.6	1.5	1.8	1.1	1
PRKCB	V							V
AKT2	V		V							V		V
IGF1	V		V		V
TGFA			V		V		V		V			V
PLCG2			V
PDGFD			V		V		V		V
IL6R			V		V		V		V
NRG2			V		V		V		V			V
SOS1				V		V				V
AKT3				V		V		V		V	V
PTEN				V		V
NF1				V							V
ERBB3					V						V
SHC3					V				V		V
KDR					V				V
RPS6KB1						V				V
SHC2						V
PIK3CA						V				V
BRAF						V				V
NRAS						V				V		V
MET						V		V		V
BCL2L11						V				V		V
VEGFA						V				V		V
PDGFC						V
NRG1						V			V
FGFR2									V
EIF4E									V
GAB1										V
SOS2										V
GAS6										V
IL6												V
+ 01524: Platinum drug resistance	0.9	0	0.8	1	0.2	1.3	0.5	2	0.5	2.1	1.2	0.9
CASP8	V		V							V		V
AKT2	V		V							V		V
CDKN1A	V							V
MGST2			V				V		V
POLH			V									V
ATP7A				V		V		V		V
TOP2A				V		V		V		V
AKT3				V		V		V		V	V
REV3L				V		V		V		V
GSTO2					V				V		V
GSTT2					V				V		V
GSTT2B					V				V		V
ATM						V
XIAP						V				V
GSTM2						V				V		V
GSTM4						V		V		V
TOP2B						V				V		V
PIK3CA						V				V
GSTA3							V
GSTA4							V		V
PMAIP1										V
BRCA1										V
BIRC3												V
+ 01523: Antifolate resistance	1.9	1.3	1.4	1	2	0.5	0.9	0.4	0.9	0.9	0.5	1
ABCC5	V
RELA	V		V		V
TNF	V							V		V
FOLR1		V		V		V
FOLR2		V		V		V
DHFR2			V				V					V
IL1B			V		V		V		V
FOLR3					V				V		V
ATIC					V
ABCG2					V				V
ABCC3						V				V		V
CHUK										V
ALOX12										V
IL6												V
+ 01522: Endocrine resistance	0.6	0	0.2	0.3	0.1	0.6	0	0.4	0.1	1.2	0.5	0.4
AKT2	V		V							V		V
CDKN1A	V							V
IGF1	V		V		V
MMP9			V				V					V
PRKACB				V		V		V		V		V
SOS1				V		V				V
AKT3				V		V		V		V	V
SHC3					V				V		V
JAG1					V				V
FOS					V				V		V
GPER1						V				V		V
NRAS						V				V		V
BRAF						V				V
SHC2						V
PIK3CA						V				V
RB1						V				V
RPS6KB1						V				V
ADCY1									V
SOS2										V
ADCY5										V
NOTCH2										V		V

**Save / Export**
META-Z-score:	download
Z-score:	download
Genes in pathway/subsystem/system:	download