Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	2nd_Lung_vs_Primary/UP	2nd_Lung_vs_Primary/DOWN	UGT2B7_KO_vs_Primary/UP	UGT2B7_KO_vs_Primary/DOWN	UGT2B7_KO_vs_2nd_Lung/UP	UGT2B7_KO_vs_2nd_Lung/DOWN	UGT2B7_KO_vs_UGT2B7_SC/UP	UGT2B7_KO_vs_UGT2B7_SC/DOWN
	162/333	319/850	1070/2804	1326/3058	1280/3294	1647/3921	193/486	193/424
+ 1. Metabolism	7	3.3	4.5	7.8	3.9	8.3	4.7	4.9
+ 1.0 Global and overview maps	3.4	0.4	1.4	2.6	0.7	3.3	1.9	0.7
+ 01100: Metabolic pathways	3.9	0	0.1	2.9	0	3.4	0.9	1.4
HSD17B8	V
ARG2	V		V
GSTT2	V
GSTT2B	V
ALDH1A3	V					V		V
G6PC3	V					V
PIK3CG	V		V
MTMR4	V		V		V
ITPKB	V		V
KYNU	V		V
GCAT	V					V
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
PDE1C	V		V
PDE2A	V					V
HDDC3	V		V
B3GNT3	V		V
HEXD	V
CYP24A1	V		V					V
DCXR	V					V
GCDH	V			V		V
ASRGL1	V					V		V
SAT1	V		V
TM7SF2	V		V				V
ACOX2	V
PLA2G4A	V		V		V
PLA2G4C	V		V
CERS1	V					V		V
CYP2J2	V					V
PTGS2	V		V		V
LIPG	V		V		V
GALNT14	V		V			V		V
ST6GALNAC5	V					V
SPHK1	V			V		V		V
NAGS	V					V
PFAS	V					V		V
ACOT2	V
ACOT1	V		V
ACSS3	V		V
QDPR	V		V
PYCR3	V					V
COX7B2	V		V
NDUFA1	V
FKTN		V	V		V
DLD		V			V
RRM2B		V	V		V
GPX8		V			V
GLS		V			V
PIK3CA		V	V		V
PTEN		V	V		V
PIK3C2A		V	V		V
MTM1		V			V
MTMR6		V			V
ACADM		V			V
ENPP1		V			V		V
NT5E		V
PDE10A		V			V
MGAT4A		V		V
B4GALT2		V		V
GCLM		V			V
PGM3		V
CYP2C9		V		V		V		V
AKR1B1		V
AKR1B10		V		V				V
HSD11B1		V		V
GGPS1		V	V		V		V
PHGDH		V		V
AMD1		V			V
ACSL3		V	V		V		V
ACSL4		V			V
AKR1C3		V
ME1		V			V
CMPK1		V			V
AGPS		V			V
ALOX5		V		V
PTGS1		V		V
GALNT1		V	V		V
GALNT7		V	V		V
UGCG		V		V
B3GNT5		V			V
TRAK2		V			V
NMRK1		V			V
NAMPT		V			V
PIGK		V			V
GYG2		V		V	V
AGL		V	V		V
GCNT1		V	V		V
CSGALNACT1		V
ISYNA1		V		V
ECHDC1		V	V		V
FASN			V
SDHD			V		V
KYAT3			V		V
EHHADH			V		V
CRPPA			V		V
CYP1A2			V		V
PHOSPHO2			V		V
PLD1			V		V
DBT			V		V
FADS1			V
HSD17B12			V		V
HACD1			V		V
SCD			V		V		V
TKFC			V
ALDOC			V				V
GSTO2			V
GGT7			V		V		V
OPLAH			V		V
ALDH3A2			V		V
ALDH7A1			V		V
SACM1L			V		V
PI4K2B			V		V
PIK3C2B			V		V		V
PIKFYVE			V		V
FIG4			V
PLCH1			V		V
PLCB1			V
PLCG1			V		V
PLCZ1			V					V
IMPA1			V		V
IMPA2			V
MINPP1			V		V
MAOA			V
HNMT			V		V
GATM			V		V
BCAT1			V		V
UPP1			V		V
NT5C			V		V
NT5C3A			V		V
FHIT			V
ENPP4			V		V
PDE11A			V		V
PDE3A			V		V
PDE4C			V		V
PDE4D			V		V
NME7			V		V
PDE5A			V		V
NPR1			V				V
PKLR			V		V
ADPRM			V		V
MDH1			V		V
DERA			V
HOGA1			V
ACSS2			V		V		V
PGM2L1			V		V
ALG13			V		V
ALG2			V		V
DLAT			V		V
ST8SIA1			V		V		V
MMAB			V				V
CHPT1			V		V
FKRP			V		V
B4GAT1			V		V
A4GALT			V		V
SMS			V		V
AK7			V		V		V
RIMKLA			V		V
NAT8L			V
PHYKPL			V		V		V
HMGCS1			V		V		V
LPIN1			V		V
DGKD			V		V
ALDH6A1			V
ACADS			V
ACADSB			V		V
MTHFD2L			V		V
FDFT1			V		V
BTD			V		V
UGDH			V		V
GNPDA2			V		V
GFPT1			V		V
NANP			V		V
RGN			V		V		V
DNMT1			V		V
PSPH			V		V
GSTZ1			V		V
ALDH8A1			V		V
BDH2			V		V
CYP51A1			V		V		V
HSD17B7			V		V		V
SC5D			V		V
HSD17B3			V		V		V
CYP2R1			V
TKTL2			V		V
PLA2G5			V		V
LCLAT1			V		V
AGPAT5			V		V
CHKB			V
ETNK1			V		V
SPTLC3			V		V
PTGES			V		V
TBXAS1			V		V		V
NUDT12			V		V
CD38			V
NNMT			V
IDI1			V		V		V
IDI2			V		V
TRIT1			V
MAN1A1			V		V		V
ST6GAL1			V
POC1B-GALNT4			V		V
GALNT5			V		V		V
CHSY1			V		V
PIGH			V
B4GALT6			V		V
ST3GAL5			V		V		V
CMBL			V
PANK3			V
PPCS			V		V
HAO1			V		V		V
ACSM3			V		V
ENO3			V
COQ5			V		V
MPI			V
NDST2			V		V
IDH1			V		V
IDH2			V		V
SUCLA2			V		V
ACOT4			V		V
RDH11			V		V
DSE			V		V
GALM			V		V
GPLD1			V		V			V
PIGL			V
PIGW			V		V
PIGM			V
GYS2			V
CSGALNACT2			V		V
DHFR2			V		V
PCCA			V		V
GNMT			V
HMGCR			V		V
AANAT			V
COX11			V
ATP6V1G3			V		V		V
ATP6V0D2			V		V		V
ATP6V1B1			V
NDUFA5			V		V
NDUFC2			V
NDUFS4			V		V
MCAT				V		V
SDHB				V		V
HADHA				V		V
CYP2A6				V		V
GMPPB				V		V
GMPPA				V		V
PLD3				V		V
BCKDHA				V
ELOVL6				V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
GSTK1				V
GGT5				V		V
LAP3				V		V
GSR				V		V
GBA3				V		V
MARS				V		V
MARS2				V		V		V
SCLY				V		V
AOC3				V		V
PAH				V		V		V
G6PC2				V		V
INPPL1				V		V
PI4KB				V		V
PI4K2A				V		V
PIP5K1C				V		V
INPP5B				V		V
INPP4A				V		V
MTMR14				V		V
MTMR2				V		V
PLCG2				V		V		V
PLCH2				V		V
INPP1				V
IMPAD1				V
CDIPT				V		V
MAOB				V
AOC1				V		V
CAD				V		V
ALAS1				V		V
ALAS2				V		V
GAD1				V		V
GAD2				V
SDSL				V		V
GSS				V		V
UGT2A3				V		V
NUDT2				V		V
UPP2				V		V
TYMP				V		V
PNP				V		V
NT5C3B				V		V
TK1				V		V
CDA				V		V
PDE8A				V
PDE1B				V		V
ADCY1				V		V
ADCY2				V		V		V
ITPA				V		V
NME6				V		V
NME1				V		V		V
ENTPD6				V		V
GMPR				V		V
PDE6D				V
PDE6H				V		V
GUK1				V		V
IMPDH2				V		V
ATIC				V		V
ADA2				V		V		V
MPST				V		V
CA5A				V		V
CA7				V		V
ACOD1				V		V
OXCT1				V		V		V
AACS				V		V
GLA				V		V
DPM2				V		V
PFKFB1				V		V
ENOSF1				V		V
MGAT3				V
PDHA1				V
PDHA2				V		V
PDHX				V		V
GBGT1				V		V
GGCT				V
HMOX2				V		V
BLVRB				V		V
GUSB				V		V
RXYLT1				V		V
POMGNT1				V		V
GALE				V		V
B4GALNT3				V		V
GCLC				V
GLDC				V		V
SMOX				V		V
SRM				V		V
CYP26A1				V		V
AK1				V		V
ALPI				V		V
ALPG				V		V
DCTPP1				V		V
PFKL				V		V
DGKK				V		V		V
DGKA				V		V
PAPSS2				V
FAH				V		V
TYRP1				V		V
ACO2				V		V
IL4I1				V
GAMT				V		V
MTHFD1				V		V
PGD				V		V
PGLS				V		V
KL				V		V		V
GALK1				V		V
GNPDA1				V		V
NANS				V		V
PMM1				V		V
PMM2				V		V
DNMT3B				V		V
CKMT2				V
HDC				V		V
PNMT				V		V
SAT2				V		V
ACMSD				V		V
ACSL1				V		V
MVD				V		V
HSD3B7				V		V
CYP11A1				V		V		V
CMPK2				V
CTPS1				V		V
UCK2				V		V
CSAD				V		V
PLB1				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
AGPAT1				V		V
AGPAT2				V		V
MBOAT1				V		V
AGPAT3				V
GPAT2				V		V		V
CHKA				V		V
ETNK2				V		V
PEMT				V		V
PAFAH2				V		V
CERS3				V		V
CERS2				V		V
SMPD2				V		V
ALOX12				V		V
PTGES2				V		V		V
PRXL2B				V		V
CBR3				V		V
QPRT				V		V
NADSYN1				V		V
NADK				V		V
MOGAT3				V		V
PNPLA2				V		V
DGAT1				V		V
DOLK				V		V
ALG8				V		V
STT3A				V		V
RPN2				V		V
MAN1B1				V		V
GALNT13				V		V
GALNT8				V		V
GALNTL6				V		V
GALNT12				V		V
ST3GAL1				V		V
CHPF2				V		V
GBA				V		V
GBA2				V		V
FUT2				V		V
B4GALNT1				V		V
ST6GALNAC6				V		V
ST6GALNAC4				V		V
PANK2				V		V
UROD				V		V
ACSM6				V		V
ENO2				V		V
DCT				V		V
GK				V
HSD17B10				V		V		V
TALDO1				V		V
DCTD				V		V
DUT				V		V
QARS				V		V
GATC				V		V
GATB				V		V
ALG3				V		V
ALG12				V		V
SORD				V		V
EXTL3				V		V
SGSH				V		V
IDH3A				V		V
IDH3B				V		V
IDH3G				V		V
FH				V		V
DHRS9				V		V		V
RDH16				V
TREH				V		V
ARSB				V		V
HYAL1				V		V
SPAM1				V		V
NMRK2				V		V		V
ACY1				V		V
PIGO				V		V
PIGU				V		V
PIGT				V		V
B3GNT6				V		V
PYGM				V		V
B4GALT7				V		V
VKORC1L1				V		V
ADSSL1				V		V
ACP5				V		V
FLAD1				V		V
MTHFS				V		V
G6PD				V		V
PCCB				V		V
GAPDHS				V		V		V
ETHE1				V		V
PYCR2				V		V
PYCR1				V		V
P4HA2				V		V
ACOT8				V		V
UQCRC1				V		V
COX8A				V		V
TCIRG1				V		V
ATP5F1B				V		V
ATP5MC1				V		V		V
ATP6V1A				V		V
ATP6V0C				V		V
ATP6V0B				V		V
ATP6V0D1				V		V
CYC1				V		V
NDUFA7				V		V
NDUFAB1				V		V
NDUFB7				V		V
NDUFB10				V		V
NDUFS3				V		V
NDUFV1				V		V
NDUFS6				V		V
NDUFS8				V		V
NDUFA13				V		V
TGDS					V
HACD2					V
SCP2					V
MTR					V
ALDH2					V
CARNMT1					V
ABAT					V		V
CA5B					V
DPM1					V
B3GALNT1					V
AMY2A					V
HIBCH					V
UGP2					V
GNE					V
MMUT					V
HAAO					V
CYP27B1					V
DPYD					V
MBOAT2					V
AGK					V
LPCAT2					V
SGMS2					V
CYP2U1					V
PIGA					V
PANK1					V
OAT					V
AASS					V
QRSL1					V
GNS					V
EXTL2					V
AMPD3					V
ADSS					V
P4HA1					V
ATP6V1C1					V
NDUFB5					V
ARG1						V
PDXP						V
AGXT2						V
RRM2						V
GSTT1						V
GGT1						V
ANPEP						V
NAT8B						V
CARNS1						V
AOC2						V
PLCB2						V
INPP5A						V
IPPK						V
CNDP1						V
GADL1						V
GOT2						V
BCAT2						V
UGT2B11						V
DTYMK						V
ENTPD8						V
ENTPD3						V
PDE4A						V
NME4						V
MOCS1						V
PDE6B						V
NPR2						V
ADA						V
APRT						V
CA3						V
GRHPR						V
DPM3						V
KHK						V
B3GAT1						V
GAA						V
MGAM						V		V
PPOX						V
LARGE2						V
CHIA						V
CYP2C18						V
PLPP2						V
IDO2						V
AKR1A1						V
CRYL1						V
ADI1						V
MRI1						V
ASL						V
HGD						V
BHMT						V
IVD						V
MCCC2						V
ACSBG1						V
PMVK						V
MVK						V
HSD17B6						V
DHODH						V		V
BAAT						V
PLA2G4E						V
PLA2G4F						V
LPCAT4						V
PAFAH1B3						V
CYP4F2						V
ALOX15						V
CYP4F8						V
CYP2E1						V
BST1						V
PNLIP						V	V
DGAT2						V
GALNT18						V
ST3GAL2						V
PIGQ						V
FUT1						V
PGAM2						V
HAO2						V
ACSM4						V
RDH12						V
HYAL3						V
AHCY						V
B3GALT6						V
B3GAT3						V
PCBD1						V
NAT2						V
ACP2						V
AMDHD2						V
SUOX						V
INMT						V
COX6A2						V
ATP5F1D						V
ATP6V0A1						V
ATP6V1F						V
NDUFS7						V
NDUFC1						V
NDUFS2						V
NDUFB11						V
HACD4							V
INPP5D							V
SDS							V
CHAC1							V
IDUA							V
ALPP							V
SQLE							V
B3GALT4							V
FUT7							V
PDE3B								V
PCYT1B								V
B3GALT1								V
KMO								V
ODC1								V
+ 01200: Carbon metabolism	0	0.1	1.1	0.7	0.5	0.2	1.4	0
DLD		V			V
PHGDH		V		V
ME1		V			V
ALDOC			V				V
TKTL2			V		V
ENO3			V
PKLR			V		V
DLAT			V		V
MDH1			V		V
SDHD			V		V
SUCLA2			V		V
IDH1			V		V
IDH2			V		V
PCCA			V		V
PSPH			V		V
TKFC			V
ME2			V		V
RGN			V		V		V
ACADS			V
EHHADH			V		V
ALDH6A1			V
ACSS2			V		V		V
HAO1			V		V		V
PFKL				V		V
G6PD				V		V
PGLS				V		V
PGD				V		V
TALDO1				V		V
ENO2				V		V
PDHA1				V
PDHA2				V		V
FH				V		V
SDHB				V		V
IDH3A				V		V
IDH3B				V		V
IDH3G				V		V
ACO2				V		V
PCCB				V		V
SDSL				V		V
GLDC				V		V
HADHA				V		V
MMUT					V
HIBCH					V
PGAM2						V
GOT2						V
HAO2						V
SDS							V
+ 01210: 2-Oxocarboxylic acid metabolism	1.1	0	0.7	1.5	0.5	2.4	0	0
NAGS	V					V
IDH1			V		V
IDH2			V		V
BCAT1			V		V
ACO2				V		V
IDH3A				V		V
IDH3B				V		V
IDH3G				V		V
ACY1				V		V
GOT2						V
BCAT2						V
+ 01212: Fatty acid metabolism	1.1	0.7	1	0	0.6	0	1.4	0
HSD17B8	V
CPT1C	V		V
ACSL3		V	V		V		V
ACSL4		V			V
ACADM		V			V
FASN			V
HSD17B12			V		V
HACD1			V		V
EHHADH			V		V
SCD			V		V		V
ACADS			V
ACADSB			V		V
FADS1			V
MCAT				V		V
ELOVL6				V
HADHA				V		V
ACSL1				V		V
HACD2					V
SCP2					V
ACSBG1						V
HACD4							V
+ 01230: Biosynthesis of amino acids	1.5	0	0.3	0.8	0	1.4	0.6	0.2
NAGS	V					V
ARG2	V		V
PYCR3	V					V
PHGDH		V		V
ENO3			V
PKLR			V		V
ALDOC			V				V
TKTL2			V		V
BCAT1			V		V
PSPH			V		V
IDH1			V		V
IDH2			V		V
ENO2				V		V
PFKL				V		V
SDSL				V		V
ACO2				V		V
IDH3A				V		V
IDH3B				V		V
IDH3G				V		V
ACY1				V		V
PYCR2				V		V
PYCR1				V		V
TALDO1				V		V
PAH				V		V		V
MTR					V
PGAM2						V
BCAT2						V
GOT2						V
ASL						V
ARG1						V
SDS							V
+ 1.1 Carbohydrate metabolism	2.8	2.3	3.3	2.6	2.5	1.9	2.4	1.7
+ 00010: Glycolysis / Gluconeogenesis	1	0.1	0.4	0	0.2	0.1	0.7	0.8
ALDH1A3	V					V		V
G6PC3	V					V
DLD		V			V
ALDOC			V				V
ALDH3A2			V		V
ALDH7A1			V		V
DLAT			V		V
PKLR			V		V
ENO3			V
GALM			V		V
ACSS2			V		V		V
MINPP1			V		V
PDHA1				V
PDHA2				V		V
ENO2				V		V
GAPDHS				V		V		V
PFKL				V		V
G6PC2				V		V
ALDH2					V
AKR1A1						V
PGAM2						V
+ 00020: Citrate cycle (TCA cycle)	0	0.3	1.1	1.7	1.2	0.8	0	0
DLD		V			V
SUCLA2			V		V
IDH1			V		V
IDH2			V		V
MDH1			V		V
DLAT			V		V
SDHD			V		V
IDH3A				V		V
IDH3B				V		V
IDH3G				V		V
FH				V		V
ACO2				V		V
PDHA1				V
PDHA2				V		V
SDHB				V		V
+ 00030: Pentose phosphate pathway	0	0	0.4	0.6	0	0.3	1.4	0
DERA			V
TKTL2			V		V
ALDOC			V				V
RGN			V		V		V
PFKL				V		V
PGD				V		V
PGLS				V		V
G6PD				V		V
TALDO1				V		V
+ 00040: Pentose and glucuronate interconversions	3	0.8	0.6	0.5	0.2	0.9	0	1.4
DCXR	V					V
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
AKR1B1		V
AKR1B10		V		V				V
CRPPA			V		V
UGDH			V		V
GUSB				V		V
KL				V		V		V
UGT2A3				V		V
SORD				V		V
UGP2					V
CRYL1						V
UGT2B11						V
AKR1A1						V
+ 00051: Fructose and mannose metabolism	0	0.8	0.3	1.8	0	1.2	0.6	0.6
AKR1B1		V
AKR1B10		V		V				V
PFKFB4			V
MPI			V
ALDOC			V				V
TKFC			V
SORD				V		V
PFKFB1				V		V
PMM1				V		V
PMM2				V		V
GMPPB				V		V
GMPPA				V		V
PFKL				V		V
ENOSF1				V		V
KHK						V
+ 00052: Galactose metabolism	0.8	1.4	0	1.2	0	1.1	0	1.4
G6PC3	V					V
AKR1B1		V
AKR1B10		V		V				V
B4GALT2		V		V
GALM			V		V
GLA				V		V
PFKL				V		V
GALE				V		V
G6PC2				V		V
GALK1				V		V
UGP2					V
GAA						V
MGAM						V		V
+ 00053: Ascorbate and aldarate metabolism	2.5	0	1.7	0	1	0	0.7	0
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
UGDH			V		V
RGN			V		V		V
ALDH3A2			V		V
ALDH7A1			V		V
UGT2A3				V		V
ALDH2					V
UGT2B11						V
+ 00500: Starch and sucrose metabolism	0.7	1.3	0.1	0.4	0.5	0.5	0.5	0.6
G6PC3	V					V
ENPP1		V			V		V
GYG2		V		V	V
AGL		V	V		V
PGM2L1			V		V
GYS2			V
GBA3				V		V
G6PC2				V		V
TREH				V		V
PYGM				V		V
UGP2					V
AMY2A					V
GAA						V
MGAM						V		V
+ 00520: Amino sugar and nucleotide sugar metabolism	0	0.5	0.2	0.9	0.2	0.9	0	0
PGM3		V
CYB5R4		V
NANP			V		V
GNPDA2			V		V
GFPT1			V		V
UGDH			V		V
MPI			V
NANS				V		V
GNPDA1				V		V
CYB5R2				V
GALE				V		V
PMM1				V		V
PMM2				V		V
GALK1				V		V
GMPPB				V		V
GMPPA				V		V
GNE					V
UGP2					V
AMDHD2						V
CHIA						V
CYB5R3						V
+ 00620: Pyruvate metabolism	0	0.6	1	0.1	1.6	0	0.5	0
ME1		V			V
DLD		V			V
PKLR			V		V
ME2			V		V
MDH1			V		V
ACSS2			V		V		V
ALDH3A2			V		V
ALDH7A1			V		V
DLAT			V		V
PDHA1				V
PDHA2				V		V
FH				V		V
ALDH2					V
GRHPR						V
+ 00630: Glyoxylate and dicarboxylate metabolism	0	0.3	0.8	0.2	0.9	0.3	1.4	0
DLD		V			V
HOGA1			V
HAO1			V		V		V
MDH1			V		V
PCCA			V		V
ACSS2			V		V		V
ACO2				V		V
PCCB				V		V
GLDC				V		V
MMUT					V
HAO2						V
GRHPR						V
+ 00640: Propanoate metabolism	0.8	0.8	2	0.1	1.9	0	1.2	0
ACSS3	V		V
ECHDC1		V	V		V
DLD		V			V
ALDH6A1			V
PCCA			V		V
ACSS2			V		V		V
EHHADH			V		V
ACADS			V
SUCLA2			V		V
DBT			V		V
PCCB				V		V
HADHA				V		V
BCKDHA				V
ABAT					V		V
HIBCH					V
MMUT					V
+ 00650: Butanoate metabolism	0	0	0.9	1.1	0.6	0.6	1.4	0.7
BDH2			V		V
HMGCS1			V		V		V
EHHADH			V		V
ACADS			V
ACSM3			V		V
OXCT1				V		V		V
AACS				V		V
HADHA				V		V
GAD1				V		V
GAD2				V
ACSM6				V		V
ABAT					V		V
ACSM4						V
+ 00562: Inositol phosphate metabolism	1.5	1.6	2.6	1.1	0.9	0.4	0.6	0.7
ITPKB	V		V
MTMR4	V		V		V
PIK3CG	V		V
PTEN		V	V		V
MTM1		V			V
ISYNA1		V		V
MTMR6		V			V
PIK3CA		V	V		V
PIK3C2A		V	V		V
MINPP1			V		V
IMPA1			V		V
IMPA2			V
PI4K2B			V		V
PLCH1			V		V
PLCB1			V
PLCG1			V		V
PLCZ1			V					V
ALDH6A1			V
PIKFYVE			V		V
PIK3C2B			V		V		V
SACM1L			V		V
FIG4			V
INPP5B				V		V
INPP1				V
INPP4A				V		V
IMPAD1				V
PI4KB				V		V
PI4K2A				V		V
PIP5K1C				V		V
MTMR14				V		V
MTMR2				V		V
PLCG2				V		V		V
PLCH2				V		V
CDIPT				V		V
INPPL1				V		V
INPP5A						V
PLCB2						V
IPPK						V
INPP5D							V
+ 1.2 Energy metabolism	0.2	0	0	1.5	0	1.2	0.3	0
+ 00190: Oxidative phosphorylation	0.4	0	0	0.5	0	0.7	0.4	0.1
NDUFA1	V
COX7B2	V		V
LHPP		V	V		V		V
NDUFC2			V
NDUFA5			V		V
NDUFS4			V		V
COX11			V
ATP6V1G3			V		V		V
ATP6V0D2			V		V		V
ATP6V1B1			V
PPA2			V
SDHD			V		V
NDUFB10				V		V
NDUFB7				V		V
NDUFAB1				V		V
NDUFA7				V		V
NDUFV1				V		V
NDUFS8				V		V
NDUFS6				V		V
NDUFS3				V		V
NDUFA13				V		V
COX8A				V		V
CYC1				V		V
UQCRC1				V		V
TCIRG1				V		V
ATP5F1B				V		V
ATP5MC1				V		V		V
ATP6V1A				V		V
ATP6V0C				V		V
ATP6V0B				V		V
ATP6V0D1				V		V
SDHB				V		V
NDUFB5					V
ATP6V1C1					V
NDUFC1						V
NDUFS7						V
NDUFS2						V
NDUFB11						V
COX6A2						V
ATP5F1D						V
ATP6V0A1						V
ATP6V1F						V
+ 00910: Nitrogen metabolism	0	0	0	0.3	0.1	0.4	0	0
CA5A				V		V
CA7				V		V
CA5B					V
CA3						V
+ 00920: Sulfur metabolism	0	0	0	1.9	0	1	0	0
IMPAD1				V
PAPSS2				V
MPST				V		V
ETHE1				V		V
SUOX						V
+ 1.3 Lipid metabolism	5.6	1.5	2.3	2.4	1.6	3	2.4	2.5
+ 00061: Fatty acid biosynthesis	1.1	1.3	0.3	0.2	0.2	0.3	0.9	0
HSD17B8	V
ACSL3		V	V		V		V
ACSL4		V			V
FASN			V
MCAT				V		V
ACSL1				V		V
ACSBG1						V
+ 00062: Fatty acid elongation	1.8	0	0.6	0.1	0.4	0	0.7	0
ACOT2	V
ACOT1	V		V
HSD17B12			V		V
HACD1			V		V
ACOT4			V		V
HADHA				V		V
ELOVL6				V
HACD2					V
HACD4							V
+ 00071: Fatty acid degradation	1.4	1	0.7	0	0.7	0	0.4	0
GCDH	V			V		V
CPT1C	V		V
ACADM		V			V
ACSL3		V	V		V		V
ACSL4		V			V
ACADSB			V		V
ACADS			V
EHHADH			V		V
ALDH3A2			V		V
ALDH7A1			V		V
HADHA				V		V
ACSL1				V		V
ALDH2					V
ECI2						V
ACSBG1						V
+ 00072: Synthesis and degradation of ketone bodies	0	0	0.8	0.2	0.6	0.1	1.2	1.3
HMGCS1			V		V		V
BDH2			V		V
OXCT1				V		V		V
+ 00100: Steroid biosynthesis	2	0	2.5	0	1.2	0	3.3	0.9
TM7SF2	V		V				V
CYP24A1	V		V					V
SC5D			V		V
CYP51A1			V		V		V
HSD17B7			V		V		V
CYP2R1			V
FDFT1			V		V
SOAT1				V
CYP27B1					V
SQLE							V
+ 00120: Primary bile acid biosynthesis	1.1	0	0	1.1	0.2	1.1	0	1
ACOX2	V
CYP46A1				V		V		V
CH25H				V		V
HSD3B7				V		V
ACOT8				V		V
CYP7B1					V
SCP2					V
BAAT						V
+ 00140: Steroid hormone biosynthesis	2.3	1.1	0.4	0.2	0.2	0	0.8	0.9
HSD17B8	V
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
AKR1C3		V
AKR1C1		V		V
HSD11B1		V		V
CYP1B1		V		V
HSD17B12			V		V
HSD17B7			V		V		V
SULT2B1			V		V
CYP1A2			V		V
HSD17B3			V		V		V
CYP11A1				V		V		V
SRD5A2				V		V
DHRS11				V		V
UGT2A3				V		V
STS					V
CYP7B1					V
HSD17B6						V
UGT2B11						V
CYP2E1						V
AKR1C2								V
+ 00561: Glycerolipid metabolism	0.4	0.3	0.4	1.4	0.5	0.9	0.3	1.4
LIPG	V		V		V
AKR1B1		V
AKR1B10		V		V				V
LPIN1			V		V
LCLAT1			V		V
AGPAT5			V		V
TKFC			V
ALDH3A2			V		V
ALDH7A1			V		V
DGKD			V		V
PNPLA2				V		V
MOGAT3				V		V
DGAT1				V		V
AGPAT1				V		V
AGPAT2				V		V
MBOAT1				V		V
AGPAT3				V
GPAT2				V		V		V
GK				V
GLA				V		V
DGKK				V		V		V
DGKA				V		V
MBOAT2					V
AGK					V
ALDH2					V
PNLIP						V	V
DGAT2						V
PLPP2						V
AKR1A1						V
+ 00564: Glycerophospholipid metabolism	0.7	0	0.4	1.8	0.4	1.6	0	0.9
PLA2G4A	V		V		V
PLA2G4C	V		V
LPGAT1		V
CHPT1			V		V
CHKB			V
ETNK1			V		V
PLA2G5			V		V
DGKD			V		V
LPIN1			V		V
PLD1			V		V
LCLAT1			V		V
AGPAT5			V		V
GPD1L			V		V
ADPRM			V		V
CHKA				V		V
ETNK2				V		V
PLB1				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
DGKK				V		V		V
DGKA				V		V
PLD3				V		V
AGPAT1				V		V
AGPAT2				V		V
MBOAT1				V		V
AGPAT3				V
CDIPT				V		V
GPAT2				V		V		V
LCAT				V		V
PNPLA6				V		V
LYPLA2				V		V
PEMT				V		V
PLA2G15				V		V
MBOAT7				V		V
LPCAT2					V
MBOAT2					V
GPD2					V
LYPLA1					V
LPCAT4						V
PLA2G4E						V
PLA2G4F						V
PLPP2						V
GPD1						V
PCYT1B								V
+ 00565: Ether lipid metabolism	1.3	0.2	0.4	0.3	0.4	1	0	0
PLA2G4A	V		V		V
PLA2G4C	V		V
AGPS		V			V
CHPT1			V		V
PLA2G5			V		V
PLD1			V		V
GDPD1			V		V
PAFAH2				V		V
PLB1				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
PLD3				V		V
LPCAT2					V
PLPP2						V
PAFAH1B3						V
PLA2G4E						V
PLA2G4F						V
LPCAT4						V
+ 00600: Sphingolipid metabolism	1.3	0.2	0	1.6	0	1.5	0	1.7
CERS1	V					V		V
SPHK1	V			V		V		V
UGCG		V		V
SGPP1			V		V
SPTLC3			V		V
B4GALT6			V		V
ACER3				V		V
CERS3				V		V
CERS2				V		V
SMPD2				V		V
GLA				V		V
NEU2				V		V
GBA				V		V
GBA2				V		V
ARSA				V		V		V
SGMS2					V
PLPP2						V
NEU1						V
+ 00590: Arachidonic acid metabolism	2.3	1.5	0.1	1.1	0.1	1.8	0.3	0.8
CYP2J2	V					V
PTGS2	V		V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
CYP2C9		V		V		V		V
GPX8		V			V
PTGS1		V		V
ALOX5		V		V
AKR1C3		V
PLA2G5			V		V
PTGES			V		V
TBXAS1			V		V		V
ALOX12				V		V
PLB1				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
GGT5				V		V
PTGES2				V		V		V
CBR3				V		V
PRXL2B				V		V
CYP2U1					V
CYP4F2						V
ALOX15						V
PLA2G4E						V
PLA2G4F						V
GGT1						V
CYP4F8						V
CYP2E1						V
+ 00591: Linoleic acid metabolism	2.5	0.4	0.5	0.7	0.2	2	0	0.7
PLA2G4A	V		V		V
PLA2G4C	V		V
CYP2J2	V					V
CYP2C9		V		V		V		V
CYP1A2			V		V
PLA2G5			V		V
PLB1				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
ALOX15						V
PLA2G4E						V
PLA2G4F						V
CYP2E1						V
+ 00592: alpha-Linolenic acid metabolism	1.9	0	0.4	0.6	0.1	0.9	0	0
PLA2G4A	V		V		V
PLA2G4C	V		V
PLA2G5			V		V
PLB1				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
PLA2G4E						V
PLA2G4F						V
+ 01040: Biosynthesis of unsaturated fatty acids	1.8	0	1.3	0	1	0	1.4	0
ACOT2	V
ACOT1	V		V
HSD17B12			V		V
HACD1			V		V
ACOT4			V		V
SCD			V		V		V
FADS1			V
ELOVL6				V
HACD2					V
SCP2					V
BAAT						V
HACD4							V
+ 1.4 Nucleotide metabolism	0.9	1	0.3	2.4	0.3	3	0.5	1.7
+ 00230: Purine metabolism	1.3	0.2	0.4	0.7	0.2	1	0.5	1.4
PDE1C	V		V
PDE2A	V					V
HDDC3	V		V
PFAS	V					V		V
RRM2B		V	V		V
PDE10A		V			V
NT5E		V
ENPP1		V			V		V
PDE11A			V		V
PDE3A			V		V
NME7			V		V
AK7			V		V		V
NT5C			V		V
NT5C3A			V		V
NPR1			V				V
PDE5A			V		V
ADPRM			V		V
FHIT			V
ENPP4			V		V
PKLR			V		V
PDE4C			V		V
PDE4D			V		V
ATIC				V		V
PDE1B				V		V
ADCY1				V		V
ADCY2				V		V		V
NME6				V		V
NME1				V		V		V
AK1				V		V
ADSSL1				V		V
NT5C3B				V		V
PNP				V		V
ADA2				V		V		V
GMPR				V		V
IMPDH2				V		V
ENTPD6				V		V
GUK1				V		V
PDE6D				V
PDE6H				V		V
PAPSS2				V
ITPA				V		V
NUDT2				V		V
PDE8A				V
ADSS					V
AMPD3					V
AK3					V
RRM2						V
ENTPD8						V
ENTPD3						V
NME4						V
APRT						V
ADA						V
NPR2						V
PDE6B						V
PDE4A						V
PDE3B								V
+ 00240: Pyrimidine metabolism	0	1.2	0.1	2.8	0.3	3.2	0.3	0.9
RRM2B		V	V		V
CMPK1		V			V
NT5E		V
ENPP1		V			V		V
NME7			V		V
NT5C			V		V
NT5C3A			V		V
UPP1			V		V
CAD				V		V
NME6				V		V
NME1				V		V		V
CMPK2				V
CTPS1				V		V
ENTPD6				V		V
UCK2				V		V
NT5C3B				V		V
UPP2				V		V
CDA				V		V
DCTPP1				V		V
DCTD				V		V
TK1				V		V
PNP				V		V
TYMP				V		V
NUDT2				V		V
DUT				V		V
DPYD					V
RRM2						V
NME4						V
ENTPD8						V
ENTPD3						V
DTYMK						V
DHODH						V		V
+ 1.5 Amino acid metabolism	2.8	1	2.2	2.8	2.4	3.4	1.2	2.2
+ 00250: Alanine, aspartate and glutamate metabolism	0.7	0.2	0.1	0.4	0.3	0.5	0.5	0.6
ASRGL1	V					V		V
GLS		V			V
NAT8L			V
GFPT1			V		V
RIMKLA			V		V
IL4I1				V
ADSSL1				V		V
CAD				V		V
GAD1				V		V
GAD2				V
ADSS					V
ABAT					V		V
GOT2						V
ASL						V
AGXT2						V
+ 00260: Glycine, serine and threonine metabolism	0.7	0.6	0.4	1	0.1	1.7	0.5	0
GCAT	V					V
PHGDH		V		V
DLD		V			V
ALDH7A1			V		V
GATM			V		V
PSPH			V		V
MAOA			V
GNMT			V
GAMT				V		V
SDSL				V		V
GLDC				V		V
ALAS1				V		V
ALAS2				V		V
MAOB				V
AOC3				V		V
BHMT						V
GRHPR						V
AOC2						V
AGXT2						V
PGAM2						V
SDS							V
+ 00270: Cysteine and methionine metabolism	0	0.9	0.2	0.6	0.5	1.1	0.4	0
AMD1		V			V
GCLM		V			V
PHGDH		V		V
KYAT3			V		V
DNMT1			V		V
SMS			V		V
MDH1			V		V
BCAT1			V		V
SRM				V		V
DNMT3B				V		V
IL4I1				V
SDSL				V		V
MPST				V		V
GCLC				V
GSS				V		V
MTR					V
ADI1						V
MRI1						V
BHMT						V
AHCY						V
GOT2						V
BCAT2						V
AGXT2						V
SDS							V
+ 00280: Valine, leucine and isoleucine degradation	0	0.5	1.4	0.4	2.2	0.4	0.9	1.1
DLD		V			V
ACADM		V			V
HMGCS1			V		V		V
EHHADH			V		V
BCAT1			V		V
ACADSB			V		V
DBT			V		V
PCCA			V		V
ALDH3A2			V		V
ALDH7A1			V		V
ALDH6A1			V
ACADS			V
BCKDHA				V
OXCT1				V		V		V
HADHA				V		V
IL4I1				V
PCCB				V		V
HSD17B10				V		V		V
AACS				V		V
MMUT					V
ALDH2					V
ABAT					V		V
HIBCH					V
MCCC2						V
IVD						V
BCAT2						V
AGXT2						V
+ 00290: Valine, leucine and isoleucine biosynthesis	0	0	0.7	0.7	0.6	1.3	1.7	0
BCAT1			V		V
SDSL				V		V
BCAT2						V
SDS							V
+ 00310: Lysine degradation	0.5	0.1	1.8	0.8	2.4	0.4	0.3	0.4
GCDH	V			V		V
DLD		V			V
EHHADH			V		V
ALDH7A1			V		V
KMT5A			V		V
KMT2A			V		V
NSD3			V		V
ASH1L			V		V
SETMAR			V		V
PRDM2			V		V
DOT1L			V		V
PRDM6			V		V
PLOD2			V		V
ALDH3A2			V		V
PHYKPL			V		V		V
HADHA				V		V
TMLHE				V		V
EZH1				V		V
EZH2				V		V		V
SUV39H1				V		V
SETD3				V		V
KMT5C				V		V
SETD1A				V		V
KMT2B				V		V
AASS					V
KMT5B					V
ALDH2					V
KMT2E						V
+ 00220: Arginine biosynthesis	2	0.5	0	0	0	0.8	0	0
ARG2	V		V
NAGS	V					V
GLS		V			V
ACY1				V		V
ASL						V
ARG1						V
GOT2						V
+ 00330: Arginine and proline metabolism	1.9	0.1	0.8	1.5	0.5	1.6	0	0.4
ARG2	V		V
SAT1	V		V
PYCR3	V					V
AMD1		V			V
GATM			V		V
ALDH3A2			V		V
ALDH7A1			V		V
SMS			V		V
MAOA			V
HOGA1			V
AOC1				V		V
SRM				V		V
SAT2				V		V
MAOB				V
GAMT				V		V
CKMT2				V
SMOX				V		V
PYCR2				V		V
PYCR1				V		V
P4HA2				V		V
LAP3				V		V
ALDH2					V
OAT					V
P4HA1					V
ARG1						V
CARNS1						V
CNDP1						V
GOT2						V
ODC1								V
+ 00340: Histidine metabolism	1	0	0.8	0.4	1	0.7	0	0.9
ALDH1A3	V					V		V
ALDH3A2			V		V
ALDH7A1			V		V
MAOA			V
HNMT			V		V
MAOB				V
AOC1				V		V
HDC				V		V
CARNMT1					V
ALDH2					V
CARNS1						V
CNDP1						V
+ 00350: Tyrosine metabolism	0.7	0	0	1	0	1.1	0	0.6
ALDH1A3	V					V		V
GSTZ1			V		V
MAOA			V
MAOB				V
IL4I1				V
AOC3				V		V
FAH				V		V
DCT				V		V
PNMT				V		V
TYRP1				V		V
HGD						V
GOT2						V
AOC2						V
+ 00360: Phenylalanine metabolism	1.2	0	0.1	1.2	0	1.2	0	2
ALDH1A3	V					V		V
MAOA			V
AOC3				V		V
MAOB				V
IL4I1				V
PAH				V		V		V
AOC2						V
GOT2						V
+ 00380: Tryptophan metabolism	1.4	0.6	1.4	0.7	1.1	0.1	0	0.5
GCDH	V			V		V
KYNU	V		V
CYP1B1		V		V
DLD		V			V
EHHADH			V		V
CYP1A2			V		V
AANAT			V
MAOA			V
ALDH8A1			V		V
KYAT3			V		V
ALDH3A2			V		V
ALDH7A1			V		V
IL4I1				V
MAOB				V
HADHA				V		V
ACMSD				V		V
AOC1				V		V
HAAO					V
ALDH2					V
IDO2						V
INMT						V
KMO								V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	1.3	0	1.1	0	1.6
IL4I1				V
PAH				V		V		V
GOT2						V
+ 1.6 Metabolism of other amino acids	0.7	0.8	0.8	2.8	1.1	2.8	1	1.8
+ 00410: beta-Alanine metabolism	0.8	0	1	0.8	1.4	1.7	0.6	0.7
ALDH1A3	V					V		V
ACADS			V
EHHADH			V		V
ALDH6A1			V
SMS			V		V
ALDH3A2			V		V
ALDH7A1			V		V
HADHA				V		V
GAD1				V		V
GAD2				V
SRM				V		V
AOC3				V		V
SMOX				V		V
HIBCH					V
ABAT					V		V
ALDH2					V
DPYD					V
CARNS1						V
GADL1						V
AOC2						V
CNDP1						V
+ 00430: Taurine and hypotaurine metabolism	0	0	0.2	1.7	0.2	2.5	1.2	0
GGT7			V		V		V
CSAD				V		V
GAD1				V		V
GAD2				V
GGT5				V		V
GADL1						V
GGT1						V
BAAT						V
+ 00440: Phosphonate and phosphinate metabolism	0	0	0.5	0	0.4	0	0	1.5
CHPT1			V		V
PCYT1B								V
+ 00450: Selenocompound metabolism	0	0	0.1	1.6	0.2	0.7	0	1
KYAT3			V		V
TXNRD1				V
MARS				V		V
MARS2				V		V		V
SCLY				V		V
PAPSS2				V
MTR					V
INMT						V
+ 00471: D-Glutamine and D-glutamate metabolism	0	1.3	0	0	0.5	0	0	0
GLS		V			V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0	0	0	0
+ 00480: Glutathione metabolism	1.1	0.8	0.4	3.4	0.3	2.5	0.8	1.5
GSTT2	V
GSTT2B	V
GPX8		V			V
GCLM		V			V
RRM2B		V	V		V
GGT7			V		V		V
IDH1			V		V
IDH2			V		V
OPLAH			V		V
GSTO2			V
SMS			V		V
GGT5				V		V
G6PD				V		V
GSS				V		V
GCLC				V
GGCT				V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
GSTK1				V
GSR				V		V
PGD				V		V
SRM				V		V
LAP3				V		V
ANPEP						V
GGT1						V
NAT8B						V
GSTT1						V
RRM2						V
CHAC1							V
ODC1								V
+ 1.7 Glycan biosynthesis and metabolism	1.4	1.9	2.3	3.6	1.5	4	2.4	1.2
+ 00510: N-Glycan biosynthesis	0	0.5	0.1	1.8	0	0.6	0.4	0
B4GALT2		V		V
MGAT4A		V		V
ST6GAL1			V
MAN1A1			V		V		V
ALG2			V		V
ALG13			V		V
DPM2				V		V
ALG12				V		V
ALG3				V		V
DOLPP1				V		V
MGAT3				V
MAN1B1				V		V
STT3A				V		V
DOLK				V		V
ALG8				V		V
RPN2				V		V
DPM1					V
DPM3						V
+ 00512: Mucin type O-glycan biosynthesis	0.8	1.5	1.1	1	0.5	1.5	0.6	0.7
GALNT14	V		V			V		V
GCNT1		V	V		V
GALNT1		V	V		V
GALNT7		V	V		V
POC1B-GALNT4			V		V
GALNT5			V		V		V
ST3GAL1				V		V
B3GNT6				V		V
GALNT13				V		V
GALNT8				V		V
GALNTL6				V		V
GALNT12				V		V
ST3GAL2						V
GALNT18						V
+ 00515: Mannose type O-glycan biosynthesis	0	1.1	0.8	0.3	0.6	0.4	0	0
B4GALT2		V		V
FKTN		V	V		V
B4GAT1			V		V
CRPPA			V		V
FKRP			V		V
POMGNT1				V		V
RXYLT1				V		V
B3GAT1						V
LARGE2						V
+ 00514: Other types of O-glycan biosynthesis	0	1.1	1.3	0.4	0.6	0	0.8	0
B4GALT2		V		V
GXYLT1		V			V
ST6GAL1			V
LFNG			V		V		V
POGLUT1			V
GXYLT2			V		V
EOGT			V		V
POFUT2				V
POFUT1				V		V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	0.6	1	1.8	0.4	1.8	0	0
CSGALNACT1		V
CHSY1			V		V
CSGALNACT2			V		V
UST			V
DSE			V		V
B4GALT7				V		V
CHPF2				V		V
CHST13				V		V
CHST11				V
CHST3				V		V
CHST14				V		V
B3GAT3						V
B3GALT6						V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1	0	1.3	0.7	1	1.5	0.8	0
HS3ST2	V		V		V		V
NDST2			V		V
HS3ST1			V
HS2ST1			V		V
HS6ST3			V		V
EXTL3				V		V
HS3ST3B1				V		V
HS6ST1				V		V
B4GALT7				V		V
EXTL2					V
HS6ST2						V
B3GALT6						V
B3GAT3						V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	0.7	0	1.4	0	1	0	2.1
B4GALT2		V		V
CHST6				V		V		V
ST3GAL1				V		V
CHST4				V		V		V
ST3GAL2						V
+ 00531: Glycosaminoglycan degradation	0	0	0	1.4	0	1.4	0.9	0
SGSH				V		V
ARSB				V		V
HYAL1				V		V
SPAM1				V		V
GUSB				V		V
GNS					V
HYAL3						V
IDUA							V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	0.5	1.6	0.7	0.9	0.6	0	0.8
PIGK		V			V
PIGH			V
PIGM			V
PIGL			V
GPLD1			V		V			V
PIGW			V		V
PIGZ			V		V
DPM2				V		V
PIGU				V		V
PIGT				V		V
PIGO				V		V
PIGA					V
PIGQ						V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0.9	1	0.3	0.1	0.4	0	1.5	0.8
B3GNT3	V		V
B4GALT2		V		V
B3GNT5		V			V
ST8SIA1			V		V		V
A4GALT			V		V
FUT2				V		V
B3GALNT1					V
FUT1						V
FUT7							V
B3GALT1								V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0.4	1.3	0.7	1.8	1	0
A4GALT			V		V
ST8SIA1			V		V		V
ST3GAL1				V		V
FUT2				V		V
GLA				V		V
GBGT1				V		V
B3GALNT1					V
ST3GAL2						V
FUT1						V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	1.2	0	0.4	1.3	0.3	1.8	2.8	0
ST6GALNAC5	V					V
ST8SIA1			V		V		V
ST3GAL5			V		V		V
ST3GAL1				V		V
B4GALNT1				V		V
ST6GALNAC6				V		V
ST6GALNAC4				V		V
ST3GAL2						V
B3GALT4							V
+ 00511: Other glycan degradation	1.1	0	0.1	1	0	1.9	0	0
HEXD	V
AGA			V
NEU2				V		V
MAN2B1				V		V
GBA				V		V
GBA2				V		V
NEU1						V
MAN2C1						V
ENGASE						V
+ 1.8 Metabolism of cofactors and vitamins	1.5	1.5	1.4	1.6	1.6	1.7	1.9	1.3
+ 00730: Thiamine metabolism	0	0	0.1	0.8	0.1	0.5	1.9	0
AK7			V		V		V
AK1				V		V
ALPI				V		V
ALPG				V		V
ALPP							V
+ 00740: Riboflavin metabolism	0	1	0	1.6	0.3	1.9	1.3	0
ENPP1		V			V		V
FLAD1				V		V
BLVRB				V		V
ACP5				V		V
ACP2						V
+ 00750: Vitamin B6 metabolism	0	0	0.5	0	0.4	0.3	0	0
PHOSPHO2			V		V
PDXP						V
+ 00760: Nicotinate and nicotinamide metabolism	0	2	0.8	1	0.8	0.8	0.6	0.7
ENPP1		V			V		V
NMRK1		V			V
NAMPT		V			V
NT5E		V
NUDT12			V		V
CD38			V
NNMT			V
NT5C			V		V
NT5C3A			V		V
QPRT				V		V
NMRK2				V		V		V
PNP				V		V
NADSYN1				V		V
NADK				V		V
NT5C3B				V		V
BST1						V
+ 00770: Pantothenate and CoA biosynthesis	0	0.6	1	0.2	2.1	0.6	0.9	0.9
ENPP1		V			V		V
PANK3			V
VNN2			V		V
BCAT1			V		V
PPCS			V		V
PANK2				V		V
VNN1				V		V		V
PANK1					V
DPYD					V
AASDHPPT					V
BCAT2						V
GADL1						V
+ 00780: Biotin metabolism	0	0	0.9	0	0.8	0	0	0
BTD			V		V
+ 00785: Lipoic acid metabolism	0	0	0	0	0	0	0	0
+ 00790: Folate biosynthesis	0.9	1.7	0.1	0.6	0	0.5	0.7	1.6
QDPR	V		V
AKR1B1		V
AKR1B10		V		V				V
AKR1C3		V
DHFR2			V		V
ALPI				V		V
ALPG				V		V
PAH				V		V		V
MOCS1						V
PCBD1						V
ALPP							V
+ 00670: One carbon pool by folate	0	0	0.6	0.5	0.7	0.2	0	0
MTHFD2L			V		V
DHFR2			V		V
MTFMT			V		V
MTHFD1				V		V
MTHFS				V		V
ATIC				V		V
MTR					V
+ 00830: Retinol metabolism	2.2	0.1	0.3	0.2	0	0.2	0.7	1.3
LRAT	V		V		V
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
CYP2C9		V		V		V		V
RDH11			V		V
RETSAT			V		V
CYP1A2			V		V
CYP27C1			V		V		V
DGAT1				V		V
CYP26A1				V		V
RDH16				V
DHRS9				V		V		V
CYP2A6				V		V
UGT2A3				V		V
SDR16C5				V		V		V
RDH12						V
CYP2C18						V
UGT2B11						V
HSD17B6						V
AWAT2							V
+ 00860: Porphyrin and chlorophyll metabolism	2.1	0	0.3	0.7	0	0.7	0.4	0
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
HCCS			V		V
MMAB			V				V
GUSB				V		V
UGT2A3				V		V
BLVRB				V		V
UROD				V		V
ALAS1				V		V
ALAS2				V		V
HMOX2				V		V
UGT2B11						V
PPOX						V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0	0	0.3	0.2	0.2	0.1	0	0
COQ5			V		V
VKORC1L1				V		V
+ 1.9 Metabolism of terpenoids and polyketides	0	0.5	1.2	0.7	1.3	1.4	2.3	0.8
+ 00900: Terpenoid backbone biosynthesis	0	0.5	1.2	0.7	1.3	1.4	2.3	0.8
GGPS1		V	V		V		V
HMGCS1			V		V		V
HMGCR			V		V
IDI1			V		V		V
IDI2			V		V
MVD				V		V
DHDDS				V		V
PDSS1				V		V		V
ZMPSTE24				V
FNTA					V
MVK						V
PMVK						V
CHURC1-FNTB						V
RCE1						V
+ 1.10 Biosynthesis of other secondary metabolites	0	0	0.4	0.4	0.4	0.8	0	0
+ 00232: Caffeine metabolism	0	0	0.6	0.6	0.5	1.1	0	0
CYP1A2			V		V
CYP2A6				V		V
NAT2						V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	0	0	0	0	0	0
+ 1.11 Xenobiotics biodegradation and metabolism	5.1	0.6	0.1	3.6	0	2.4	0.1	3
+ 00980: Metabolism of xenobiotics by cytochrome P450	3.1	0.8	0	1.8	0	0.6	0	1.7
GSTT2	V
GSTT2B	V
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
ALDH1A3	V					V		V
CYP1B1		V		V
AKR1C1		V		V
HSD11B1		V		V
CYP2C9		V		V		V		V
GSTO2			V
CYP1A2			V		V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
GSTK1				V
UGT2A3				V		V
CBR3				V		V
CYP2A6				V		V
CYP2E1						V
GSTT1						V
UGT2B11						V
+ 00982: Drug metabolism - cytochrome P450	3.2	0.1	0.1	1.5	0	0.7	0.2	2.3
ALDH1A3	V					V		V
GSTT2	V
GSTT2B	V
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
CYP2C9		V		V		V		V
CYP1A2			V		V
GSTO2			V
MAOA			V
FMO2				V		V		V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
GSTK1				V
UGT2A3				V		V
CYP2A6				V		V
MAOB				V
FMO3					V		V
GSTT1						V
UGT2B11						V
CYP2E1						V
+ 00983: Drug metabolism - other enzymes	2.5	0.2	0.1	3.1	0	3	0	1.1
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
GSTT2	V
GSTT2B	V
CMPK1		V			V
RRM2B		V	V		V
UPP1			V		V
NME7			V		V
GSTO2			V
ITPA				V		V
UPP2				V		V
TYMP				V		V
UCK2				V		V
TK1				V		V
IMPDH2				V		V
CDA				V		V
CES2				V		V
UGT2A3				V		V
GUSB				V		V
NME6				V		V
NME1				V		V		V
DUT				V		V
CYP2A6				V		V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
DPYD					V
NAT2						V
UGT2B11						V
NME4						V
RRM2						V
CYP2E1						V
GSTT1						V
+ 2. Genetic Information Processing	0.5	2.8	1.3	6.6	3	5.7	0.2	2.3
+ 2.1 Transcription	0	0.7	0.5	3	1.1	2.4	0.2	0.8
+ 03020: RNA polymerase	0	0.3	0	2.4	0	2.4	0	1.4
TWISTNB		V
POLR3F			V		V
POLR2A				V		V
POLR2D				V		V
POLR2F				V		V
POLR2L				V		V
POLR2J				V		V
POLR3B				V		V
POLR1C				V		V
POLR3K				V		V
POLR1A				V		V
ZNRD1				V		V
POLR2G						V
POLR3D						V
POLR3G								V
POLR1E								V
+ 03022: Basal transcription factors	0	0.5	0.1	1.1	0.4	0	0.4	0
TAF2		V
TAF12		V		V
TAF11			V		V
GTF2B			V		V
TAF15			V		V
CCNH			V		V
TAF1L				V
TAF6				V		V
TAF7L				V		V
TAF10				V		V
GTF2F1				V		V
ERCC2				V		V
ERCC3				V
TAF13				V
TAF1					V
GTF2I					V
GTF2F2					V
TBPL2							V
+ 03040: Spliceosome	0	0.4	0.7	1.8	1.5	1.7	0	0
PRPF40A		V			V
U2SURP		V	V		V
HNRNPA3		V	V		V
CDC5L		V		V
THOC2		V			V
DDX39B			V		V
RBM25			V		V
SNRPE			V		V
DDX5			V		V
SF3B1			V		V
TRA2A			V		V
SRSF3			V		V
SRSF5			V		V
SRSF7			V		V
BCAS2			V		V
HSPA1L			V		V
CRNKL1			V		V
LSM8			V		V
SNRNP27			V		V
EIF4A3			V
ALYREF			V
SLU7			V		V
PRPF38B			V		V
SNRPA				V		V
SNRPB				V		V
SNRPD3				V		V
SNRPA1				V		V
SF3A3				V		V
SF3A2				V		V
SF3B4				V		V
SF3B3				V		V
U2AF2				V		V
U2AF1L4				V		V
PUF60				V		V
RBMXL3				V		V
HNRNPA1L2				V		V
PQBP1				V		V
WBP11				V		V
PPIL1				V		V
CCDC12				V		V
LSM4				V		V
LSM7				V		V
LSM2				V		V
PRPF31				V		V
PRPF3				V		V
SNRNP40				V		V
DDX23				V		V
ACIN1				V		V
ZMAT2				V
BUD31				V		V
DDX46					V
CDC40					V
DHX15					V
SF3B6					V
HNRNPK					V
SRSF1					V
AQR					V
THOC1					V
DHX38						V
DHX8						V
PHF5A						V
SRSF9						V
CTNNBL1						V
PRPF6						V
TXNL4A						V
SART1						V
+ 2.2 Translation	0.7	1.3	0.3	3.1	1.1	2.7	0	2.1
+ 03010: Ribosome	0	0	0	0.1	0	0.1	0	0.6
RPS18			V		V
RPS3A			V
RPL27A			V					V
RPL31			V		V
RPL34			V
RPL37			V
RPL7A			V		V
RPL14			V		V
MRPS7			V
MRPS6			V		V
MRPS16			V
MRPL2				V		V
MRPL3				V		V
RPL8				V		V
MRPL23				V		V
UBA52				V		V
RPL10				V		V
MRPL12				V		V
MRPL27				V		V
MRPL35				V		V
MRPS5				V		V
MRPS9				V		V
RPS5				V		V
MRPS12				V		V
MRPS15				V		V
MRPS18A				V		V
MRPS2				V		V
RPS10						V
RPL23						V		V
RPL23A						V
MRPL4						V
MRPS11						V
RPL26								V
+ 00970: Aminoacyl-tRNA biosynthesis	0.6	0.2	0	3	0.1	2.6	0	0.5
YARS2	V					V
DARS		V
GARS			V		V
LARS2			V		V
MTFMT			V		V
HARS2				V		V
FARSB				V		V
FARS2				V		V
FARSA				V		V
RARS				V
QARS				V		V
SARS2				V		V
MARS				V		V
MARS2				V		V		V
VARS				V		V
AARS				V		V
WARS2				V		V
YARS				V		V
GATC				V		V
GATB				V		V
TARSL2					V
QRSL1					V
WARS						V
+ 03013: RNA transport	0.3	1.4	0.2	0.7	1.5	0.6	0	0.4
NUP210	V		V		V
CYFIP2	V					V		V
XPO1		V	V		V
NXT2		V			V
RANBP2		V	V		V
EIF1AX		V			V
EIF3E		V			V
EIF3A		V	V		V
THOC2		V			V
UPF2		V			V
EIF5B		V			V
FXR1		V			V
EIF4A3			V
CASC3			V		V
PNN			V		V
ALYREF			V
TPR			V		V
SUMO3			V		V
SUMO2			V		V
NMD3			V		V
DDX39B			V		V
TRNT1			V		V
RPP30			V		V
THOC5			V		V
PAIP1			V		V
EIF5			V		V
FMR1			V		V
GEMIN4				V		V
SNUPN				V		V
ACIN1				V		V
RNPS1				V		V
NXT1				V		V
NUP188				V		V
RAE1				V		V
NUP214				V		V
NUP88				V		V
AAAS				V		V
UPF1				V		V
EIF1AY				V		V
EIF3B				V		V
EIF3G				V		V
EIF3H				V		V
RPP40				V		V		V
RPP21				V		V
PABPC4				V		V
EIF4E1B				V		V	V
EIF4G1				V		V
UPF3B				V
EIF4EBP1				V		V
TACC3				V		V
EIF2B3				V		V
EIF2B5				V		V
FXR2				V		V
PHAX					V
GEMIN8					V
NUP153					V
SUMO1					V
EEF1A1					V
ELAC1					V
THOC1					V
EIF2S1					V
NUP35					V
CLNS1A						V
EIF3CL						V
EIF3C						V
POP1						V		V
RPP25						V
EIF2B4						V
+ 03015: mRNA surveillance pathway	0.7	0.3	0.3	0.8	0.6	0.3	0	0.2
PPP2R2C	V		V
MSI2	V
NXT2		V			V
UPF2		V			V
PPP1CB		V			V
EIF4A3			V
CASC3			V		V
PNN			V		V
ALYREF			V
DDX39B			V		V
PCF11			V		V
CPSF6			V		V
PPP2CB			V		V
PPP2R3A			V		V
PPP1CC			V		V
ACIN1				V		V
RNPS1				V		V
NXT1				V		V
UPF3B				V
UPF1				V		V
SMG5				V		V
SMG7				V		V
SMG6				V		V
GSPT2				V		V		V
CLP1				V		V
CPSF1				V		V
CSTF2				V		V
PABPC4				V		V
PPP1CA				V		V
SSU72				V		V
SMG1					V
PAPOLA					V
PPP2R5C					V
HBS1L					V
SYMPK						V
PPP2R3B						V
+ 03008: Ribosome biogenesis in eukaryotes	0	1.1	0.1	2.4	0.2	2.6	0	3.1
XPO1		V	V		V
NOP58		V		V
XRN1		V	V		V
NXT2		V			V
MPHOSPH10		V			V
NMD3			V		V
NOP10			V		V
UTP14C			V		V
RPP30			V		V
RIOK1			V		V
TCOF1				V		V
NOP56				V		V		V
DROSHA				V		V
NAT10				V		V
UTP14A				V		V
RPP40				V		V		V
GNL3				V		V
GNL2				V		V
NVL				V		V
NXT1				V		V
IMP4				V		V		V
UTP4				V		V		V
WDR43				V		V
TBL3				V		V
CSNK2A1				V		V
CSNK2B				V		V
NOL6				V		V		V
EIF6				V		V
EMG1				V		V
RIOK2					V
DKC1						V		V
RCL1						V
POP1						V		V
RPP25						V
RRP7A						V
NOB1						V
+ 2.3 Folding, sorting and degradation	0.2	2.3	0.5	3.6	2	2.7	0.1	0.7
+ 03060: Protein export	0	0.5	0.4	0.1	1.3	0.4	0	0.8
SEC62		V	V		V
SRP14			V		V
SEC61G			V		V
SRPRA				V		V
SEC11C				V		V		V
SRP9					V
SEC63					V
SPCS3					V
SPCS1						V
SRPRB						V
+ 04141: Protein processing in endoplasmic reticulum	0.1	2.5	0.2	2.3	1.8	1.5	0.1	0
WFS1	V			V		V
EDEM3		V			V
LMAN1		V			V
UGGT2		V			V
SEC62		V	V		V
ATF6B		V		V
YOD1		V	V		V
PLAA		V			V
UBE2D1		V	V		V
DNAJC10		V			V
DNAJC3		V
NFE2L2		V			V
TRAM1		V	V		V
HSPH1		V			V
CRYAB		V	V		V
MAP3K5			V		V
SEC61G			V		V
EDEM1			V		V
SEC23B			V		V
SEC23A			V		V
SEC24D			V		V
ERO1A			V		V
MAN1A1			V		V		V
ATXN3			V		V
HSPA1L			V		V
SEL1L			V		V
DERL1			V
HERPUD1			V		V		V
SAR1B			V		V
HSPA4L			V		V
DDIT3				V		V
TRAF2				V		V
MAP2K7				V		V
CALR				V		V
CAPN1				V		V
STT3A				V		V
RPN2				V		V
SEC24C				V		V
LMAN2				V		V
NPLOC4				V		V
MAN1B1				V		V
MARCH6				V
BAX				V		V
EIF2AK1				V		V
XBP1				V		V
RAD23A				V		V
UBQLN2				V		V
UBQLN4				V		V
UBE2J2				V		V
UBE4B				V		V
UBE2D4				V		V
DNAJC5G				V		V
P4HB				V		V
TXNDC5				V		V		V
PDIA4				V		V
DNAJC1				V		V
NSFL1C				V		V
UBXN6				V		V
RNF185				V		V
SEC31A				V		V
LMAN1L				V		V
HSPBP1				V		V
SIL1				V		V
BCAP31				V		V
EIF2S1					V
CAPN2					V
ERO1B					V
SEC63					V
RAD23B					V
UBE2J1					V
ERLEC1					V
HSP90AA1					V
HSP90B1					V
DERL3						V
PREB						V
BAG1						V
SSR2						V
SSR4						V
+ 04130: SNARE interactions in vesicular transport	0	0.8	0	1.1	0.6	0.6	0	0.6
BET1		V
VAMP7		V			V
VTI1A			V		V
SNAP23			V		V
YKT6				V		V
STX5				V		V
SEC22B				V
STX1A				V		V
STX3				V		V
VAMP8				V		V
VAMP3				V
STX17					V
STX7					V
VAMP4					V
GOSR2						V
STX10						V
STX11								V
+ 04120: Ubiquitin mediated proteolysis	0	1.4	0.4	0.4	1.2	0	0	0.2
DET1		V			V
UBE2W		V	V		V
CUL5		V	V		V
CUL4B		V			V
BIRC3		V			V			V
XIAP		V			V
UBE2D1		V	V		V
UBA6		V	V		V
UBE2Q2		V			V
UBA2			V		V
RHOBTB1			V		V
CDC27			V		V
CUL3			V		V
FANCL			V		V
RCHY1			V		V
SIAH1			V		V
UBE3A			V		V
UBE2K			V		V
HERC2			V
UBE2R2			V		V
UBE2E3			V		V
UBE2E1			V		V
UBE2E2			V
SAE1				V		V
RHOBTB2				V		V
SOCS1				V		V
UBA3				V
CDC20				V		V
MGRN1				V		V
PIAS4				V		V
PIAS1				V
CBLC				V		V
CBLB				V		V
UBE2D4				V		V
SMURF1				V		V
SMURF2				V
UBE3C				V		V
UBE2J2				V		V
UBA1				V		V
UBE4B				V		V
HUWE1				V
UBE2O				V		V
UBE2M				V		V
WWP1					V
UBE2J1					V
ITCH					V
BIRC6					V
NEDD4L					V
UBE2B					V
ANAPC5						V
CUL7						V
UBE2U						V
KLHL13							V
SKP2								V
+ 04122: Sulfur relay system	0	0	0	0.9	0	1.3	0	0
URM1				V		V
MPST				V		V
CTU2						V
+ 03050: Proteasome	0	0.2	0	3	0	1.9	0	0
PSMB9		V		V
PSMD11				V		V
PSMD8				V		V
PSMD2				V		V
ADRM1				V		V
PSMC4				V		V
PSMC3				V		V
PSMC5				V		V
PSMA6				V		V
PSMB7				V		V
PSMB2				V		V
PSMB1				V		V
PSMB4				V		V
PSMB10				V
PSMB8				V		V
PSMD14					V
POMP					V
PSME3						V
+ 03018: RNA degradation	0.3	0.8	0.1	1.7	0.3	1.5	0.2	0
DCPS	V					V
TTC37		V	V		V
DIS3		V			V
MTREX		V
XRN1		V	V		V
ENO3			V
CNOT6L			V		V
CNOT8			V		V
LSM8			V		V
DHX36			V		V
BTG1			V		V
ENO2				V		V
EXOSC1				V		V
SKIV2L				V		V
EXOSC5				V		V
EXOSC10				V		V
TENT4A				V		V
CNOT3				V		V
CNOT4				V		V
CNOT9				V		V
CNOT10				V		V
DCP1A				V
LSM2				V		V
LSM4				V		V
LSM7				V		V
HSPA9				V		V
PABPC4				V		V
PFKL				V		V
C1D					V
DCP2					V
PAN3					V
EXOSC4						V
EXOSC7						V
EXOSC2						V
TOB1							V
+ 2.4 Replication and repair	0	1.2	1.2	3.5	1.7	3.6	0	1
+ 03030: DNA replication	0	0	0	2.3	0	2.3	0	0.6
RNASEH2A				V		V
RFC2				V		V
MCM5				V		V
POLD4				V		V
MCM2				V		V
MCM3				V		V
MCM4				V		V
POLA2				V		V
POLD2				V		V
POLE				V		V
MCM7				V
RPA4					V
LIG1						V
RNASEH2C						V
POLE4						V
PRIM1								V
+ 03410: Base excision repair	0	0.3	0	2.2	0	4	0	0
HMGB1		V	V		V
APEX2				V		V
APEX1				V		V
PARP2				V		V
LIG3				V		V
POLE				V		V
POLD2				V		V
POLD4				V		V
MUTYH				V		V
XRCC1				V		V
POLL				V		V
PARP3						V
LIG1						V
POLE4						V
UNG						V
NEIL2						V
OGG1						V
SMUG1						V
+ 03420: Nucleotide excision repair	0	0.5	0	0.5	0.4	0.3	0	0
CUL4B		V			V
ERCC6		V			V
CCNH			V		V
ERCC4			V		V
ERCC2				V		V
ERCC3				V
RFC2				V		V
POLE				V		V
POLD2				V		V
POLD4				V		V
RAD23A				V		V
ERCC5					V
RPA4					V
RAD23B					V
LIG1						V
POLE4						V
+ 03430: Mismatch repair	0	0	0	0.7	0.1	0.6	0	0
POLD2				V		V
POLD4				V		V
PMS2				V		V
RFC2				V		V
MSH2					V
RPA4					V
LIG1						V
+ 03440: Homologous recombination	0	0	1.2	2	1.4	1.6	0	1.2
RAD52			V
RAD50			V		V
NBN			V		V
BRCA2			V		V
RAD54B			V		V
SYCP3			V		V
BRIP1			V		V
ATM			V		V
TOP3A				V		V
TOP3B				V		V
BLM				V
RAD51D				V		V
EME1				V		V
RAD54L				V		V
POLD2				V		V
POLD4				V		V
RBBP8				V
BARD1				V		V
BABAM1				V		V
RPA4					V
ABRAXAS1					V
BRCC3					V
XRCC3						V
RAD51B						V
UIMC1						V
XRCC2								V
RAD51								V
+ 03450: Non-homologous end-joining	0	0.8	1.1	0.5	0.9	0.3	0	0
LIG4		V	V		V
RAD50			V		V
XRCC4			V		V
POLL				V		V
PRKDC				V		V
+ 03460: Fanconi anemia pathway	0	1.7	0.9	1.2	1.8	0.4	0	1
RMI1		V	V		V
ATR		V			V
USP1		V			V
POLK		V	V		V
REV3L		V			V
FANCM			V		V
FANCL			V		V
RMI2			V
BRCA2			V		V
BRIP1			V		V
POLI			V		V
ERCC4			V		V
FANCA				V		V
FANCD2				V
FANCE				V		V
FAAP100				V		V
BLM				V
TOP3A				V		V
TOP3B				V		V
ATRIP				V		V
TELO2				V		V		V
PMS2				V		V
EME1				V		V
FANCB					V
RPA4					V
FAN1					V
CENPX						V
RAD51								V
+ 3. Environmental Information Processing	6.1	3.5	3.6	6.2	3	6.1	4.4	5.9
+ 3.1 Membrane transport	0.6	0.2	0.7	0.2	1.2	0	1.6	0
+ 02010: ABC transporters	0.6	0.2	0.7	0.2	1.2	0	1.6	0
ABCA3	V		V
ABCA1		V		V
ABCG8			V		V
ABCC6			V		V
ABCC5			V		V
ABCB4			V		V		V
ABCA10			V		V
ABCA5			V		V
ABCG5				V		V
ABCD1				V		V
ABCB6				V		V
TAP1				V
CFTR					V
ABCC4					V
ABCB10					V
TAP2					V
ABCG4						V
ABCC2						V
ABCG1							V
ABCA13							V
+ 3.2 Signal transduction	6.4	4.8	5	7.4	3.6	6.2	3.5	5.1
+ 04010: MAPK signaling pathway	0.8	1.2	0.3	2.8	0.4	2.9	1.3	0.1
DUSP1	V					V
DUSP2	V			V		V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
FOS	V		V
EREG	V		V		V
DUSP10		V		V
RASA1		V			V
PRKACB		V			V
RASA2		V			V
MET		V			V
NGFR		V			V		V
ATF2		V			V
AKT3		V
TAOK1		V			V
STK3		V	V		V
TGFBR1		V
TNF		V		V		V		V
MAP3K2		V			V
RPS6KA3		V	V		V
NGF		V		V
NTF3		V		V			V
PPM1B			V		V
MAPT			V
RELA			V
NF1			V		V
KRAS			V		V
ERBB4			V
FGFR3			V
KDR			V
CACNA2D4			V		V
MEF2C			V		V		V
MAP2K6			V		V		V
PPM1A			V		V
MAP3K5			V		V
FAS			V		V
IL1RAP			V		V
TGFB3			V		V
RAC1			V		V
RAC3			V		V
HSPA1L			V		V
JUND			V
PPP3CA			V		V
PPP3CC			V
MAP4K3			V		V
MYC			V		V
MKNK2			V		V
EFNA3			V
FGF20			V		V
ANGPT1			V
PGF			V		V		V
PDGFC			V		V
TGFA			V		V
PDGFD			V		V
FGF17			V		V
DUSP7				V		V
PTPN5				V		V
PLA2G4D				V		V
NFKB1				V		V
NFKB2				V		V
RELB				V		V
MAPK1				V		V
MAP2K2				V		V
PRKCG				V		V
PRKACG				V		V
HRAS				V		V
RRAS				V		V
RASGRP4				V		V
GRB2				V		V
EGFR				V
FGFR4				V		V	V
FLT1				V		V
FLT3				V
INSR				V		V
CACNG3				V		V		V
CACNA1F				V		V
NR4A1				V		V
CDC25B				V		V
RPS6KA4				V		V
MAPKAPK3				V		V
DDIT3				V		V
TP53				V		V
ELK1				V		V
MAPK14				V
MAPK12				V		V
PPP5C				V		V
MAP2K3				V		V
MAP3K13				V		V
MAP4K2				V		V
GADD45A				V		V
TRAF2				V		V
CASP3				V
CD14				V		V
TNFRSF1A				V		V
IL1A				V		V
IL1B				V		V		V
MAPKAPK5				V		V
RAC2				V		V
MAPK8IP1				V		V
MAP2K7				V		V
ARRB1				V		V
NFATC3				V		V
SRF				V		V
RPS6KA2				V		V
CSF1				V		V
FLT3LG				V		V
IGF1				V		V
INS				V		V
NTF4				V		V
ANGPT4				V		V
PDGFA				V		V
MYD88				V		V
IRAK1				V		V
ARAF				V		V
DUSP6					V		V
MAP4K4					V
RAP1A					V
RAPGEF2					V
SOS1					V
SOS2					V
CACNB4					V
MAPKAPK2					V
MAP3K20					V
MECOM					V
KITLG					V
BDNF					V
PTPN7						V
FASLG						V
PLA2G4E						V
PLA2G4F						V
PRKACA						V
FGFR2						V
CACNG2						V
CACNA2D3						V
CACNA1D						V
CACNA1I						V
MAPK11						V
MAPK13						V
ECSIT						V
TAB1						V
PAK1						V
RPS6KA1						V
EFNA2						V
EGF						V
FGF6						V
FGF8						V
FGF22						V
CACNA2D1							V
PDGFB							V
VEGFA							V
+ 04012: ErbB signaling pathway	0.3	1	1.2	3.2	0.9	1.7	0.1	0.2
EREG	V		V		V
BUB1B-PAK6		V		V
PAK6		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
ERBB4			V
RPS6KB1			V		V
CDKN1B			V
NCK1			V		V
TGFA			V		V
NRG2			V		V
SHC2			V		V		V
SHC4			V		V
CAMK2D			V		V
PLCG1			V		V
MYC			V		V
KRAS			V		V
GRB2				V		V
ELK1				V		V
STAT5B				V		V
EGFR				V
EIF4EBP1				V		V
RPS6KB2				V		V
CDKN1A				V		V
MTOR				V		V
BAD				V		V
MAP2K7				V		V
CBLB				V		V
NRG3				V		V
SHC1				V		V
PRKCG				V		V
CAMK2B				V
PLCG2				V		V		V
NRG1				V		V
PIK3R2				V		V
SRC				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
GAB1					V
SOS1					V
SOS2					V
PAK1						V
EGF						V
+ 04014: Ras signaling pathway	0.1	1.7	0.5	2	0.6	1.3	1.5	0
PLA2G4A	V		V		V
PLA2G4C	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
NGF		V		V
NTF3		V		V			V
MET		V			V
NGFR		V			V		V
TIAM1		V
RASA1		V			V
RASA2		V			V
BUB1B-PAK6		V		V
PAK6		V		V
TBK1		V			V
PRKACB		V			V
SHOC2		V			V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
EFNA3			V
FGF20			V		V
ANGPT1			V
PGF			V		V		V
PDGFC			V		V
TGFA			V		V
PDGFD			V		V
FGF17			V		V
FGFR3			V
KDR			V
GAB2			V
RAC1			V		V
RAC3			V		V
PLD1			V		V
RELA			V
PLA2G5			V		V
RAB5A			V		V
RAB5B			V		V
RASA4			V		V		V
NF1			V		V
ARF6			V		V
CALM1			V		V
CALML4			V
GNG2			V		V
PLCG1			V		V
MAPK1				V		V
MAP2K2				V		V
HRAS				V		V
RRAS				V		V
GRB2				V		V
PIK3R2				V		V
SHC1				V		V
CSF1				V		V
FLT3LG				V		V
IGF1				V		V
INS				V		V
NTF4				V		V
ANGPT4				V		V
PDGFA				V		V
EGFR				V
FGFR4				V		V	V
FLT1				V		V
FLT3				V
INSR				V		V
RAC2				V		V
PRKCG				V		V
BAD				V		V
BCL2L1				V		V
NFKB1				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
ELK1				V		V
RAB5C				V		V
RASGRP4				V		V
RASAL3				V		V
SYNGAP1				V		V
RASSF1				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
PLCG2				V		V		V
KSR1				V		V
PRKACG				V		V
SOS1					V
SOS2					V
KITLG					V
BDNF					V
GAB1					V
RAP1A					V
GNG10					V
REL					V
EFNA2						V
EGF						V
FGF6						V
FGF8						V
FGF22						V
FGFR2						V
FASLG						V
PLA2G4E						V
PLA2G4F						V
GRIN2A						V
CALML3						V
GNB3						V
PAK1						V
PRKACA						V
PDGFB							V
VEGFA							V
PLA1A								V
+ 04015: Rap1 signaling pathway	1	0.5	0.7	0.5	0.5	0.6	2	0.1
APBB1IP	V		V
EVL	V		V
PFN2	V		V		V
ID1	V					V
PARD6A	V
NGF		V		V
MET		V			V
NGFR		V			V		V
ADORA2A		V		V
TIAM1		V
KRIT1		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
EFNA3			V
FGF20			V		V
ANGPT1			V
PGF			V		V		V
PDGFC			V		V
PDGFD			V		V
FGF17			V		V
FGFR3			V
KDR			V
RAC1			V		V
RAC3			V		V
MAP2K6			V		V		V
RAPGEF4			V		V		V
ITGB2			V		V		V
F2R			V		V
PLCB1			V
MAGI3			V		V
RAPGEF6			V		V
FARP2			V		V
GNAI3			V		V
SIPA1L2			V
KRAS			V		V
CTNND1			V		V
CALM1			V		V
CALML4			V
PLCG1			V		V
MAPK1				V		V
MAP2K2				V		V
CSF1				V		V
IGF1				V		V
INS				V		V
ANGPT4				V		V
PDGFA				V		V
EGFR				V
FGFR4				V		V	V
FLT1				V		V
INSR				V		V
RAC2				V		V
MAP2K3				V		V
MAPK14				V
MAPK12				V		V
PFN3				V		V		V
PFN1				V		V
SIPA1				V		V
FPR1				V		V
LPAR4				V		V
LPAR2				V		V
PRKD2				V		V
SRC				V		V
ADCY1				V		V
ADCY2				V		V		V
PIK3R2				V		V
SIPA1L3				V		V
HRAS				V		V
RRAS				V		V
PRKCG				V		V
RAP1A					V
KITLG					V
ENAH					V
ITGB1					V
LPAR5					V		V
CTNNB1					V
MAGI1					V
RAPGEF2					V
PRKD3					V
PRKCI					V
EFNA2						V
EGF						V
FGF6						V
FGF8						V
FGF22						V
FGFR2						V
MAPK11						V
MAPK13						V
ITGAL						V
PLCB2						V
VAV1						V
GRIN2A						V
CALML3						V
PDGFB							V
VEGFA							V
F2RL3							V
+ 04310: Wnt signaling pathway	1.9	0.4	0.6	1.2	0.4	0.8	0.1	0.7
WNT5B	V					V
CCND2	V		V
LEF1	V					V
TCF7	V					V
APC2	V		V		V
WNT10B	V					V
FZD7		V		V
ROCK2		V			V
TBL1XR1		V			V
PRKACB		V			V
ROR1		V			V
RNF43		V		V		V
PPP3CA			V		V
PPP3CC			V
CAMK2D			V		V
PLCB1			V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
RAC1			V		V
RAC3			V		V
DVL3			V		V
MYC			V		V
CTBP1			V
TCF7L2			V
TCF7L1			V		V
CREBBP			V		V
APC			V		V
SIAH1			V		V
LRP5			V		V
SFRP5			V		V
SERPINF1			V		V		V
LGR4			V		V
SMAD3				V		V
NFATC2				V		V
NFATC3				V		V
PRKCG				V		V
CAMK2B				V
RAC2				V		V
DVL1				V		V
DVL2				V		V
PRICKLE3				V		V
PPARD				V		V
CCND3				V
FOSL1				V		V
NKD2				V		V
TP53				V		V
AXIN1				V		V
PRKACG				V		V
CSNK2A1				V		V
CSNK2B				V		V
SFRP1				V		V
PORCN				V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
BAMBI				V		V
NOTUM				V		V		V
LGR6				V		V
DAAM1					V
PRICKLE2					V
CTNNB1					V
PLCB2						V
PRKACA						V
WNT4						V
WNT3A						V
MMP7								V
+ 04330: Notch signaling pathway	0	0.1	1.1	0.4	0.8	0.4	0.4	0.4
CIR1		V			V
CTBP1			V
CREBBP			V		V
KAT2A			V		V
KAT2B			V		V
NUMB			V		V
NOTCH2			V		V
NOTCH3			V		V
DVL3			V		V
LFNG			V		V		V
NCSTN				V		V
MAML1				V		V
PSENEN				V		V
NOTCH1				V		V
DVL1				V		V
DVL2				V		V
DLL4				V		V
DLL3						V
DLL1						V
DTX1								V
+ 04340: Hedgehog signaling pathway	1.3	1.4	0.6	1	0.6	0.9	0	0
HHIP	V		V
CCND2	V		V
CSNK1G3		V	V		V
PRKACB		V			V
GLI2		V			V
SPOPL		V	V		V
DHH			V		V
KIF3A			V		V
CUL3			V		V
CSNK1G2				V		V
PRKACG				V		V
PTCH2				V		V
SUFU				V		V
SMURF1				V		V
SMURF2				V
SHH				V		V
GRK2				V		V
ARRB1				V		V
GPR161					V
PRKACA						V
PTCH1						V
EVC						V
+ 04350: TGF-beta signaling pathway	2.3	1.5	3.2	0.8	1.4	0.3	0.8	1.4
LTBP1	V		V
ID1	V					V
INHBA	V			V		V		V
FST	V		V
BMP2	V		V
INHBB		V			V		V
ROCK1		V	V		V
TGFBR1		V
TNF		V		V		V		V
BMPR2		V	V		V
BMP4		V					V
GDF5		V		V
ACVR1C			V		V
SMAD6			V		V
SMAD7			V
PITX2			V		V
CREBBP			V		V
MYC			V		V
E2F5			V		V
ACVR1			V		V
INHBE			V		V
RPS6KB1			V		V
PPP2CB			V		V
TGFB3			V		V
AMHR2			V		V
BMPR1A			V		V
GDF6			V		V
SMAD1			V
SMAD9			V					V
NEO1			V
RGMB			V
FBN1			V		V
SMAD3				V		V
NODAL				V		V
E2F4				V		V
RBL1				V
ID3				V		V		V
RPS6KB2				V		V
MAPK1				V		V
SMURF1				V		V
SMURF2				V
BMP8A				V		V
NOG				V		V
BAMBI				V		V
FMOD				V		V
SMAD2					V
ZFYVE16					V		V
GDF7						V
TGIF2						V
GREM1						V
+ 04390: Hippo signaling pathway	4	1.2	2.2	0.1	2.1	0.1	1	0.4
TEAD4	V					V
PARD6A	V
WNT10B	V					V
WNT5B	V					V
APC2	V		V		V
LEF1	V					V
TCF7	V					V
CCND2	V		V
BMP2	V		V
ID1	V					V
PPP2R2C	V		V
STK3		V	V		V
PPP1CB		V			V
DLG1		V			V
TGFBR1		V
FZD7		V		V
BMP4		V					V
GDF5		V		V
BMPR2		V	V		V
GLI2		V			V
SAV1			V		V
WWTR1			V		V
CTNNA1			V		V
CCN2			V
PPP1CC			V		V
MOB1B			V		V
LLGL2			V		V		V
LLGL1			V		V
ITGB2			V		V		V
TGFB3			V		V
SMAD7			V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
DVL3			V		V
APC			V		V
TCF7L2			V
TCF7L1			V		V
MYC			V		V
SOX2			V		V
GDF6			V		V
BMPR1A			V		V
SMAD1			V
BBC3			V		V		V
PPP2CB			V		V
WWC1				V		V		V
RASSF1				V		V
BIRC5				V		V
PPP1CA				V		V
TEAD2				V
LIMD1				V		V
SMAD3				V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
DVL1				V		V
DVL2				V		V
AXIN1				V		V
CCND3				V
BMP8A				V		V
FRMD6					V
YAP1					V
MPP5					V
TEAD1					V
AJUBA					V
PRKCI					V
SMAD2					V
CTNNB1					V
CRB1						V
WNT4						V
WNT3A						V
GDF7						V
+ 04392: Hippo signaling pathway - multiple species	0.8	0.3	0.8	0.4	2	0.3	0.6	0.7
TEAD4	V					V
STK3		V	V		V
SAV1			V		V
WWTR1			V		V
MOB1B			V		V
FAT4			V		V		V
WWC1				V		V		V
TEAD2				V
RASSF1				V		V
LIMD1				V		V
FRMD6					V
YAP1					V
TEAD1					V
AJUBA					V
PAK1						V
+ 04370: VEGF signaling pathway	2.3	0.7	1.8	2.3	0.8	2.6	0.8	0.9
SPHK1	V			V		V		V
PTGS2	V		V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
KDR			V
PLCG1			V		V
PPP3CA			V		V
PPP3CC			V
SHC2			V		V		V
KRAS			V		V
RAC1			V		V
RAC3			V		V
PLCG2				V		V		V
PLA2G4D				V		V
MAPKAPK3				V		V
PIK3R2				V		V
NFATC2				V		V
PRKCG				V		V
MAPK14				V
MAPK12				V		V
SH2D2A				V		V
SRC				V		V
MAPK1				V		V
MAP2K2				V		V
HRAS				V		V
BAD				V		V
RAC2				V		V
MAPKAPK2					V
PLA2G4E						V
PLA2G4F						V
MAPK11						V
MAPK13						V
PXN						V
VEGFA							V
+ 04371: Apelin signaling pathway	0.8	0.1	0.9	1.1	0.2	0.9	0.7	1.7
SPHK1	V			V		V		V
PIK3CG	V		V
EGR1	V		V
AKT3		V
TGFBR1		V
PRKACB		V			V
PRKAA2			V		V
GNAI3			V		V
GNG2			V		V
RPS6KB1			V		V
PLCB1			V
ITPR2			V		V
KRAS			V		V
CCN2			V
MYLK4			V		V
PRKCE			V		V
MEF2C			V		V		V
HDAC5			V		V		V
GNA13			V		V
GABARAPL2			V
GABARAPL1			V		V		V
NOTCH3			V		V
ACTA2			V
PLIN1			V		V
CALM1			V		V
CALML4			V
PRKAG3				V		V		V
PRKAG1				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
PIK3R6				V		V
MAP2K2				V		V
MAPK1				V		V
RPS6KB2				V		V
MTOR				V		V
HRAS				V		V
RRAS				V		V
MYLK2				V		V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
LIPE				V		V
PLAT				V		V
SMAD3				V		V
CAMK4				V
GNG10					V
MEF2A					V
SMAD2					V
APLNR						V
PRKAB1						V
GNB3						V
PIK3R5						V
PLCB2						V
MYL4						V
PRKACA						V
CALML3						V
RYR1								V
PDE3B								V
+ 04064: NF-kappa B signaling pathway	1.7	0.8	0	4.5	0	4.6	0.4	3.1
TNFRSF11A	V					V
BCL2A1	V					V		V
PTGS2	V		V		V
CXCL2	V					V		V
BIRC3		V			V			V
TNF		V		V		V		V
XIAP		V			V
LTA		V		V
LTB		V		V
RELA			V
PLCG1			V		V
TAB3			V		V
DDX58			V		V		V
LY96			V		V
ATM			V		V
BCL2L1				V		V
IRAK1				V		V
MYD88				V		V
TRAF2				V		V
TNFRSF1A				V		V
IL1B				V		V		V
TNFSF14				V		V
TRAF3				V		V
NFKB2				V		V
RELB				V		V
NFKB1				V		V
TNFSF13B				V
CD40				V		V
CARD10				V		V
CARD11				V		V
TNFAIP3				V		V		V
TRAF1				V		V
CXCL8				V		V		V
CXCL12				V
TIRAP				V		V
TICAM1				V		V
CD14				V		V
CSNK2A1				V		V
CSNK2B				V		V
PLCG2				V		V		V
LYN				V		V
PIAS4				V		V
ERC1				V		V
EDA				V		V
EDARADD				V		V
CYLD				V		V
LTBR						V
TNFRSF13C						V
TNFSF11						V
TAB1						V
CCL21						V
EDAR						V
EDA2R						V
PLAU							V
+ 04668: TNF signaling pathway	3.4	2.6	0.2	2.7	0.3	2.4	0.1	4.2
FOS	V		V
CCL2	V			V		V		V
CXCL1	V			V		V		V
CXCL2	V					V		V
CXCL3	V					V		V
JUNB	V		V		V
MMP3	V					V		V
PTGS2	V		V		V
TNF		V		V		V		V
BIRC3		V			V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
CCL5		V		V		V
LTA		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
MAP2K6			V		V		V
RELA			V
FADD			V		V
FAS			V		V
BCL3			V		V
DNM1L			V		V
TAB3			V		V
MAP3K5			V		V
TNFRSF1A				V		V
TRAF2				V		V
MAP2K7				V		V
MAP2K3				V		V
MAPK14				V
MAPK12				V		V
NFKB1				V		V
MAPK1				V		V
RPS6KA4				V		V
CASP3				V
CSF1				V		V
IL1B				V		V		V
IL6				V		V
LIF				V		V
TNFAIP3				V		V		V
TRAF1				V		V
MMP9				V		V
NOD2				V		V
TNFRSF1B				V		V		V
PIK3R2				V		V
TRAF3				V		V
MLKL				V		V
ITCH					V
MAPK11						V
MAPK13						V
CCL20						V		V
EDN1						V
TAB1						V
+ 04066: HIF-1 signaling pathway	0	0.2	0.2	2.6	0.1	1.7	0.3	0.4
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
CREBBP			V		V
HIF1A			V		V
PLCG1			V		V
CAMK2D			V		V
ENO3			V
ANGPT1			V
RELA			V
RPS6KB1			V		V
MKNK2			V		V
CDKN1B			V
EGLN2				V		V
IGF1				V		V
INS				V		V
EGFR				V
INSR				V		V
PIK3R2				V		V
MTOR				V		V
PLCG2				V		V		V
PRKCG				V		V
PDHA1				V
PDHA2				V		V
CAMK2B				V
PFKL				V		V
ENO2				V		V
FLT1				V		V
ANGPT4				V		V
TIMP1				V		V
NFKB1				V		V
IL6				V		V
STAT3				V
EIF4EBP1				V		V
EIF4E1B				V		V	V
RPS6KB2				V		V
MAPK1				V		V
MAP2K2				V		V
CDKN1A				V		V
EGLN3					V
EGLN1					V
PDK1					V
IFNGR1					V
EGF						V
EDN1						V
NPPA						V
LTBR						V
IL6R						V		V
VEGFA							V
+ 04068: FoxO signaling pathway	1.3	0.9	1.1	1.5	0.5	1.4	0.5	0.6
G6PC3	V					V
CCND2	V		V
S1PR1	V
HOMER2	V					V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PTEN		V	V		V
PLK4		V
TNFSF10		V		V
TGFBR1		V
PRKAA2			V		V
KRAS			V		V
IRS1			V		V
IRS2			V		V
CREBBP			V		V
CDKN1B			V
RBL2			V		V
BCL6			V		V		V
ATM			V		V
HOMER3			V		V
HOMER1			V		V
BNIP3			V		V
GABARAPL2			V
GABARAPL1			V		V		V
ATG12			V		V
FBXO25			V
CCNG2			V		V		V
TGFB3			V		V
MAPK1				V		V
PRKAG3				V		V		V
PRKAG1				V		V
INS				V		V
HRAS				V		V
MAP2K2				V		V
INSR				V		V
ARAF				V		V
G6PC2				V		V
PIK3R2				V		V
EGFR				V
GRB2				V		V
IGF1				V		V
CDK2				V		V
CDKN1A				V		V
PLK2				V		V
PLK1				V		V
GADD45A				V		V
S1PR4				V		V
GRM1				V		V
SMAD3				V		V
STAT3				V
IL6				V		V
MAPK14				V
MAPK12				V		V
SOS1					V
SOS2					V
SIRT1					V
SMAD2					V
PRKAB1						V
EGF						V
FASLG						V
BCL2L11						V
IL7R						V		V
MAPK11						V
MAPK13						V
STK11						V
SKP2								V
+ 04020: Calcium signaling pathway	1.2	0.2	0.4	0.9	0.1	0.2	0.2	2.2
ITPKB	V		V
PDE1C	V		V
SPHK1	V			V		V		V
GRM5	V		V		V
BDKRB1	V					V
EDNRB		V			V
OXTR		V	V		V
ADORA2A		V		V
PRKACB		V			V
ATP2B1		V			V
ATP2B4		V			V
VDAC2			V		V
CAMK2D			V		V
PPP3CA			V		V
PPP3CC			V
CD38			V
ERBB4			V
GNA11			V
P2RX4			V
PLCG1			V		V
PLCZ1			V					V
MYLK4			V		V
ITPR2			V		V
PLCB1			V
ADRA1A			V		V
F2R			V		V
AVPR1A			V		V
CALM1			V		V
CALML4			V
TNNC2			V		V
SLC25A4			V		V
ADRB1			V		V
HRH2			V		V
ADCY1				V		V
PDE1B				V		V
PPIF				V		V		V
CAMK4				V
CAMK2B				V
CAMK1				V		V
PRKCG				V		V
PTK2B				V		V
TPCN2				V		V
EGFR				V
GRIN2D				V
P2RX3				V		V
P2RX5				V		V
PLCG2				V		V		V
MYLK2				V		V		V
PHKG2				V
ORAI1				V		V
CACNA1F				V		V
CHRM1				V		V
CHRM2				V		V
CHRM3				V		V
GRM1				V		V
TRHR				V		V		V
CXCR4				V		V
CCKBR				V		V
SLC25A6				V		V
ADCY2				V		V		V
ADRB3				V		V		V
PRKACG				V		V
STIM1				V		V
HRC				V		V
P2RX6					V		V
PHKB					V
ORAI3					V		V
EDNRA					V
ATP2A1					V
ASPH					V
GRIN2A						V
PLCB2						V
CACNA1D						V
CALML3						V
PRKACA						V
CACNA1I						V
ATP2A3							V
RYR1								V
+ 04070: Phosphatidylinositol signaling system	0.7	1.4	2	1	0.8	0.6	0.4	0.9
ITPKB	V		V
MTMR4	V		V		V
PTEN		V	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PIK3C2A		V	V		V
MTM1		V			V
MTMR6		V			V
PPIP5K2		V	V		V
PLCB1			V
PLCG1			V		V
PLCZ1			V					V
CALM1			V		V
CALML4			V
ITPR2			V		V
PIKFYVE			V		V
PI4K2B			V		V
PIK3C2B			V		V		V
DGKD			V		V
IMPA1			V		V
IMPA2			V
PIP4P2			V		V
SACM1L			V		V
PLCG2				V		V		V
CDIPT				V		V
PIK3R2				V		V
PIP5K1C				V		V
PI4KB				V		V
PI4K2A				V		V
DGKK				V		V		V
DGKA				V		V
INPP4A				V		V
INPP5B				V		V
IMPAD1				V
INPP1				V
INPPL1				V		V
MTMR14				V		V
MTMR2				V		V
PIP4P1				V		V
IP6K1				V		V
PRKCG				V		V
IPPK						V
PLCB2						V
CALML3						V
INPP5A						V
INPP5D							V
+ 04072: Phospholipase D signaling pathway	1.6	0	0.7	2.8	0.5	2.6	0.7	2
GRM5	V		V		V
PIK3CG	V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
SPHK1	V			V		V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
GAB2			V
F2R			V		V
AVPR1A			V		V
PLCG1			V		V
RAPGEF4			V		V		V
PLD1			V		V
PLCB1			V
GNA13			V		V
DGKD			V		V
PDGFC			V		V
PDGFD			V		V
ARF6			V		V
AGPAT5			V		V
MAPK1				V		V
MAP2K2				V		V
HRAS				V		V
RRAS				V		V
GRB2				V		V
PIK3R2				V		V
SHC1				V		V
EGFR				V
INSR				V		V
LPAR4				V		V
GRM1				V		V
GRM2				V		V		V
CXCR1				V		V
LPAR2				V		V
PLCG2				V		V		V
TSC2				V		V
MTOR				V		V
PIP5K1C				V		V
PIK3R6				V		V
CYTH2				V		V
ARF1				V		V
ADCY1				V		V
ADCY2				V		V		V
PTK2B				V		V
PLA2G4D				V		V
DGKK				V		V		V
DGKA				V		V
PDGFA				V		V
INS				V		V
CXCL8				V		V		V
FYN				V
AVP				V		V
AGPAT1				V		V
AGPAT2				V		V
AGPAT3				V
SOS1					V
SOS2					V
KITLG					V
GAB1					V
LPAR5					V		V
DNM3					V
CXCR2						V
PLCB2						V
PIK3R5						V
PLA2G4E						V
PLA2G4F						V
PLPP2						V
EGF						V
DNM2						V
AGT						V
PDGFB							V
MS4A2								V
+ 04071: Sphingolipid signaling pathway	1.4	1.1	1.3	1	0.6	0.6	0.1	1.1
S1PR1	V
CERS1	V					V		V
SPHK1	V			V		V		V
PPP2R2C	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
ROCK1		V	V		V
ROCK2		V			V
PTEN		V	V		V
TNF		V		V		V		V
S1PR3			V		V
GNAI3			V		V
GNA13			V		V
KRAS			V		V
PLCB1			V
SPTLC3			V		V
MAP3K5			V		V
PPP2CB			V		V
PPP2R3A			V		V
SGPP1			V		V
RELA			V
RAC1			V		V
RAC3			V		V
PLD1			V		V
GAB2			V
PRKCE			V		V
MAPK1				V		V
MAP2K2				V		V
PIK3R2				V		V
PRKCG				V		V
S1PR4				V		V
HRAS				V		V
CERS3				V		V
CERS2				V		V
SMPD2				V		V
CTSD				V		V
MAPK14				V
MAPK12				V		V
BAX				V		V
TP53				V		V
NFKB1				V		V
RAC2				V		V
TNFRSF1A				V		V
FYN				V
TRAF2				V		V
PPP2R5C					V
SGMS2					V
PLCB2						V
PPP2R3B						V
MAPK11						V
MAPK13						V
ADORA1							V
MS4A2								V
+ 04024: cAMP signaling pathway	0.4	2.2	0.3	0.3	0.7	0.2	1	0.1
ATP1A3	V			V		V
FOS	V		V
HHIP	V		V
OXTR		V	V		V
PRKACB		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
ATP2B1		V			V
ATP2B4		V			V
CREB1		V			V
CREB5		V			V
ROCK1		V	V		V
ROCK2		V			V
PPP1R12A		V	V		V
ADORA2A		V		V
PDE10A		V			V
PPP1CB		V			V
TIAM1		V
NPY1R			V		V		V
GNAI3			V		V
CALM1			V		V
CALML4			V
RAPGEF4			V		V		V
CNGA1			V		V
CAMK2D			V		V
ADRB1			V		V
GIPR			V		V
NPR1			V				V
PTGER2			V		V
PDE3A			V		V
PDE4C			V		V
PDE4D			V		V
RELA			V
CREBBP			V		V
PLD1			V		V
PPP1CC			V		V
F2R			V		V
RAC1			V		V
RAC3			V		V
CACNA1F				V		V
CHRM1				V		V
CHRM2				V		V
FFAR2				V		V
SSTR1				V		V
SSTR5				V		V
GABBR2				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
CAMK4				V
CAMK2B				V
BAD				V		V
NFKB1				V		V
RRAS				V		V
LIPE				V		V
GHRL				V		V
GRIN2D				V
ORAI1				V		V
PPP1R1B				V		V
PPP1CA				V		V
MYL9				V
RAC2				V		V
FSHB				V		V
SST				V		V
ADCYAP1				V		V
ATP2A1					V
EDNRA					V
CFTR					V
RAP1A					V
ABCC4					V
BDNF					V
CACNA1D						V
ATP1A4						V
HCAR1						V
PRKACA						V
CALML3						V
PDE4A						V
GRIN2A						V
HCN2						V
PTCH1						V
VAV1						V
PAK1						V
NPPA						V
EDN1						V
ATP2A3							V
ATP1B2							V
ADORA1							V
HTR1E							V
PDE3B								V
+ 04022: cGMP-PKG signaling pathway	1.4	1.8	2.1	0.2	1.9	0.2	1.5	1.4
KCNU1	V		V
RGS2	V		V
ATP1A3	V			V		V
PIK3CG	V		V
PDE2A	V					V
PPP1R12A		V	V		V
PPP1CB		V			V
EDNRB		V			V
ROCK1		V	V		V
ROCK2		V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
ATP2B1		V			V
ATP2B4		V			V
AKT3		V
PPP1CC			V		V
NPR1			V				V
PRKG1			V		V
PRKG2			V		V
ITPR2			V		V
KCNMB3			V		V
KCNMB1			V		V
PDE5A			V		V
CNGA1			V		V
ADRA1A			V		V
PLCB1			V
GNA11			V
TRPC6			V		V
PPP3CA			V		V
PPP3CC			V
MEF2C			V		V		V
PDE3A			V		V
PRKCE			V		V
SLC25A4			V		V
VDAC2			V		V
MYLK4			V		V
CALM1			V		V
CALML4			V
IRS1			V		V
IRS2			V		V
ADRB1			V		V
GNAI3			V		V
GNA13			V		V
PPP1CA				V		V
MYL9				V
ADRA2B				V		V		V
CACNA1F				V		V
NFATC2				V		V
NFATC3				V		V
SRF				V		V
MAP2K2				V		V
MAPK1				V		V
BAD				V		V
PIK3R6				V		V
NPPB				V		V	V
ADCY1				V		V
ADCY2				V		V		V
PPIF				V		V		V
SLC25A6				V		V
MYLK2				V		V		V
INSR				V		V
ADRB3				V		V		V
INS				V		V
EDNRA					V
MEF2A					V
ATP2A1					V
GTF2I					V
NPR2						V
PLCB2						V
CACNA1D						V
KCNJ8						V
ATP1A4						V
PIK3R5						V
CALML3						V
NPPA						V
GATA4							V
ATP2A3							V
ATP1B2							V
ADORA1							V
PDE3B								V
+ 04151: PI3K-Akt signaling pathway	1.7	0.5	0.8	1.4	0.3	1.1	2.1	0.6
G6PC3	V					V
EREG	V		V		V
PPP2R2C	V		V
PIK3CG	V		V
COL6A5	V		V
TNC	V
IBSP	V					V
RELN	V					V		V
PIK3AP1	V		V					V
CCND2	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PTEN		V	V		V
MET		V			V
NGFR		V			V		V
NGF		V		V
NTF3		V		V			V
ITGAV		V	V		V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PKN2		V	V		V
CCNE2		V			V			V
RPS6KB1			V		V
RPTOR			V
IRS1			V		V
ERBB4			V
FGFR3			V
KDR			V
F2R			V		V
MYC			V		V
CDKN1B			V
RBL2			V		V
GYS2			V
RELA			V
EFNA3			V
FGF20			V		V
ANGPT1			V
PGF			V		V		V
PDGFC			V		V
TGFA			V		V
PDGFD			V		V
FGF17			V		V
KRAS			V		V
PPP2CB			V		V
PPP2R3A			V		V
PRKAA2			V		V
DDIT4			V		V		V
PHLPP1			V
GNG2			V		V
ITGA1			V		V
ITGA2			V		V
ITGB8			V		V		V
COL4A4			V		V
COL4A5			V		V
COL4A6			V
FN1			V		V		V
LAMA5			V		V		V
THBS4			V		V
RAC1			V		V
IL4R			V		V
PRLR			V		V
OSMR			V		V
IL7			V		V
MTCP1			V		V
EIF4E1B				V		V	V
EIF4EBP1				V		V
RPS6KB2				V		V
MTOR				V		V
TSC2				V		V
PIK3R2				V		V
EGFR				V
FGFR4				V		V	V
FLT1				V		V
FLT3				V
INSR				V		V
CHRM1				V		V
CHRM2				V		V
LPAR4				V		V
LPAR2				V		V
BAD				V		V
BCL2L1				V		V
TP53				V		V
G6PC2				V		V
NFKB1				V		V
CSF1				V		V
FLT3LG				V		V
IGF1				V		V
INS				V		V
NTF4				V		V
ANGPT4				V		V
PDGFA				V		V
GRB2				V		V
HRAS				V		V
CDKN1A				V		V
CDK2				V		V
CDK4				V		V
PIK3R6				V		V
MAP2K2				V		V
MAPK1				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
LAMC3				V		V
COL1A1				V
COL1A2				V
COL2A1				V		V
COL4A2				V		V
COL6A2				V		V
COMP				V		V
LAMA4				V
LAMB3				V		V
LAMC2				V		V
IL2RG				V		V
JAK2				V		V
IL6				V		V
PRL				V		V		V
PKN1				V		V
CCND3				V
CCNE1				V		V
NR4A1				V		V
LPAR5					V		V
KITLG					V
BDNF					V
SOS1					V
SOS2					V
PPP2R5C					V
HSP90AA1					V
HSP90B1					V
GNG10					V
ITGB1					V
ITGB4					V		V
MAGI1					V
MLST8						V
FGFR2						V
FASLG						V
BCL2L11						V
EFNA2						V
EGF						V
FGF6						V
FGF8						V
FGF22						V
PPP2R3B						V
STK11						V
PIK3R5						V
GNB3						V
LAMB4						V
IL2RB						V
IL6R						V		V
IL7R						V		V
JAK3						V
IFNA6						V
IFNA14						V
IFNA21						V
MYB						V		V
PDGFB							V
VEGFA							V
THBS3							V
THBS2								V
+ 04152: AMPK signaling pathway	1.4	0.8	1.4	0.5	0.8	0.4	0.2	0.3
CPT1C	V		V
G6PC3	V					V
PPP2R2C	V		V
CCNA1	V		V		V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
LEPR		V	V		V
CREB1		V			V
CREB5		V			V
PRKAA2			V		V
IRS1			V		V
IRS2			V		V
PFKFB4			V
RPTOR			V
GYS2			V
FASN			V
SCD			V		V		V
RPS6KB1			V		V
PPP2CB			V		V
PPP2R3A			V		V
HMGCR			V		V
ADRA1A			V		V
CD36			V
RAB10			V		V
RAB14			V		V
PRKAG3				V		V		V
PRKAG1				V		V
INS				V		V
INSR				V		V
PIK3R2				V		V
IGF1				V		V
ADIPOR1				V		V
CAMKK2				V		V		V
PFKFB1				V		V
PFKL				V		V
TSC2				V		V
MTOR				V		V
G6PC2				V		V
EEF2				V		V
RPS6KB2				V		V
EIF4EBP1				V		V
LIPE				V		V
RAB11B				V		V
SIRT1					V
STRADB					V
CAB39					V
PPP2R5C					V
CFTR					V
PRKAB1						V
STK11						V
PPP2R3B						V
LEP						V
+ 04150: mTOR signaling pathway	0.3	1.2	0.7	1.7	0.9	2	1	1.6
WNT10B	V					V
WNT5B	V					V
PIK3CA		V	V		V
PIK3R1		V	V		V
PTEN		V	V		V
AKT3		V
RPS6KA3		V	V		V
TNF		V		V		V		V
RICTOR		V			V
FZD7		V		V
CLIP1		V			V
IRS1			V		V
KRAS			V		V
LPIN1			V		V
RPS6KB1			V		V
RRAGB			V		V
RRAGA			V
PRKAA2			V		V
DDIT4			V		V		V
RNF152			V		V
ATP6V1G3			V		V		V
ATP6V1B1			V
SLC38A9			V		V
FNIP1			V		V
RPTOR			V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
LRP5			V		V
DVL3			V		V
INSR				V		V
PIK3R2				V		V
MAPK1				V		V
HRAS				V		V
MAP2K2				V		V
TSC2				V		V
EIF4EBP1				V		V
RPS6KB2				V		V
PRKCG				V		V
RPS6KA2				V		V
GRB2				V		V
EIF4E1B				V		V	V
TNFRSF1A				V		V
SLC3A2				V		V
ATP6V1A				V		V
LAMTOR4				V		V
LAMTOR1				V		V
IGF1				V		V
INS				V		V
MTOR				V		V
TTI1				V		V
TELO2				V		V		V
MAPKAP1				V		V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
DVL1				V		V
DVL2				V		V
ULK2					V
SOS1					V
SOS2					V
ATP6V1C1					V
STRADB					V
CAB39					V
RPS6KA1						V
NPRL3						V
ATP6V1F						V
FLCN						V
MLST8						V
WNT4						V
WNT3A						V
STK11						V
CASTOR1							V
SKP2								V
+ 3.3 Signaling molecules and interaction	3.5	1	0.6	3.1	0.4	4.4	2.5	5.2
+ 04080: Neuroactive ligand-receptor interaction	0.6	0	0	0.4	0	1.3	2.5	1.5
PRSS3	V					V
GRM5	V		V		V
S1PR1	V
BDKRB1	V					V
GAL	V					V		V
NMU	V		V
LEPR		V	V		V
ADORA2A		V		V
OXTR		V	V		V
EDNRB		V			V
PLG			V		V
PRLR			V		V
THRB			V
NR3C1			V		V
GLRB			V		V
GRIK2			V		V		V
P2RX4			V
GABRB1			V		V		V
GIPR			V		V
S1PR3			V		V
PTGER2			V		V
PTGER4			V
HCRTR1			V		V
HCRTR2			V
F2R			V		V
F2RL1			V
F2RL2			V		V
AVPR1A			V		V
OPRL1			V		V		V
NPY1R			V		V		V
MC5R			V		V
C3AR1			V		V
HRH2			V		V
ADRA1A			V		V
ADRB1			V		V
CHRNG			V		V
CHRNA9			V		V
NPB			V		V
TAC1			V		V
GNRH1			V		V
RLN3			V		V
RLN2			V		V
UCN			V
FSHB				V		V
PRL				V		V		V
THRA				V		V
TSPO				V		V
GLRA3				V		V
GRIK3				V		V
GRIK5				V		V
GRIN2D				V
P2RX3				V		V
P2RX5				V		V
GABRA2				V		V
GABRE				V		V		V
GABBR2				V		V
GRM1				V		V
GRM2				V		V		V
GCGR				V		V		V
RXFP1				V		V
S1PR4				V		V
LPAR4				V		V
LPAR2				V		V
MTNR1B				V		V
TRHR				V		V		V
P2RY8				V		V
P2RY2				V		V
NMUR2				V
UTS2R				V		V
SSTR1				V		V
SSTR4				V		V
SSTR5				V		V
NPY2R				V		V
MC1R				V		V
CCKBR				V		V
FPR1				V		V
TAAR5				V		V
ADRA2B				V		V		V
ADRB3				V		V		V
CHRM1				V		V
CHRM2				V		V
CHRM3				V		V
CHRNB1				V		V
CHRND				V		V
CHRNA10				V
C3				V		V		V
GHRL				V		V
MLN				V		V
NPFF				V		V	V
SST				V		V
AVP				V		V
GHRH				V		V		V
ADCYAP1				V		V
GRIK4					V
P2RX6					V		V
EDNRA					V
C5					V
KISS1					V
LHB						V
LEP						V
GRID2						V
GRIN2A						V
GABRA4						V
GABRA6						V
GABRG2						V
GABRR2						V
NPBWR1						V
MLNR						V		V
GHRHR						V	V
GPR50						V
GALR2						V
OPRM1						V
APLNR						V
NMBR						V
DRD3						V
AGT						V
CCK						V
EDN1						V
PPY						V
NPW						V
PRLH						V
GNRH2						V
CALCA						V
UCN3						V
CALCRL							V
GPR35							V
ADORA1							V
F2RL3							V
NTSR2							V
HTR1E							V
CHRM4							V
NTS							V
SCT							V
+ 04060: Cytokine-cytokine receptor interaction	1.8	1	0.1	2.3	0	3.6	0.3	3.9
IL18	V		V		V
BMP2	V		V
INHBA	V			V		V		V
TNFRSF11A	V					V
CXCL1	V			V		V		V
CXCL2	V					V		V
CXCL3	V					V		V
CCL2	V			V		V		V
GDF3	V		V
BMPR2		V	V		V
LIFR		V	V		V
TGFBR1		V
GDF5		V		V
INHBB		V			V		V
LTB		V		V
LTA		V		V
CXCL11		V			V
NGFR		V			V		V
TNFSF10		V		V
TNF		V		V		V		V
CCL5		V		V		V
NGF		V		V
BMP4		V					V
LEPR		V	V		V
IL1RAP			V		V
BMPR1A			V		V
ACVR1			V		V
AMHR2			V		V
IL17B			V		V
INHBE			V		V
TGFB3			V		V
TNFRSF19			V
FAS			V		V
TNFSF18			V		V		V
IFNLR1			V		V
IL20RA			V		V
PRLR			V		V
IL4R			V		V
IL7			V		V
OSMR			V		V
IL12B			V		V
TNFRSF12A			V
TNFRSF10B			V		V
TNFSF15			V		V
ACKR4			V		V
CCR10			V
CCR4			V
CCR6			V		V
CD4			V		V
ACVR1C			V		V
BMP3			V		V
GDF9			V		V
GDF6			V		V
IL20RB				V
IL2RG				V		V
CSF2RB				V		V
IL18RAP				V		V		V
IL1B				V		V		V
IL1A				V		V
IL17A				V		V
RELT				V		V
TNFRSF9				V		V
CD40				V		V
TNFRSF14				V		V
EDA				V		V
TNFSF13B				V
TNFSF14				V		V
IL24				V		V
MPL				V		V
CRLF2				V		V
IL15RA				V		V
PRL				V		V		V
CNTFR				V		V
IL23A				V		V
CTF1				V		V
LIF				V		V
IL11				V
IL6				V		V
CXCR4				V		V
CXCR1				V		V
CXCL16				V		V
CXCL12				V
CXCL8				V		V		V
PPBP				V		V
TNFRSF1A				V		V
TNFRSF1B				V		V		V
TNFRSF10A				V		V
IL17RE				V
CCL11				V		V
CCL16				V		V
CCL14				V		V
CCL17				V		V
CCL15				V		V
IL27				V		V
IL1RN				V
IL36A				V		V		V
IL1RL2				V		V
IL32				V		V		V
CSF1				V		V
INHA				V		V
NODAL				V		V
MSTN				V		V
BMP8A				V		V
IL10RB					V
IL6ST					V
IFNGR1					V
IL2RB						V
IL25						V
EDA2R						V
EDAR						V
TNFRSF13C						V
TNFRSF13B						V
TNFRSF18						V
TNFRSF4						V
TNFRSF8						V
LTBR						V
FASLG						V
IL10RA						V
IFNL2						V
IFNL3						V
IFNK						V	V
IFNA6						V
IFNA14						V
IFNA21						V
IL7R						V		V
IL6R						V		V
IL13						V
CLCF1						V
CXCR3						V
CXCR2						V
CXCL9						V
TNFRSF10D						V
TNFSF11						V
IL17F						V
CCL21						V
CCL23						V
CCL20						V		V
GDF7						V
LEP						V
IL33							V
PF4V1								V
ACVRL1								V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	2.2	0.8	0	3	0	3.7	0	4.4
CCL2	V			V		V		V
CXCL1	V			V		V		V
CXCL2	V					V		V
CXCL3	V					V		V
IL18	V		V		V
CCL5		V		V		V
CXCL11		V			V
LTA		V		V
TNF		V		V		V		V
TNFSF10		V		V
CCR4			V
CCR6			V		V
ACKR4			V		V
CCR10			V
IL20RA			V		V
TNFRSF10B			V		V
CCL14				V		V
CCL15				V		V
CCL16				V		V
CCL11				V		V
CCL17				V		V
CXCL8				V		V		V
CXCR1				V		V
PPBP				V		V
CXCL12				V
CXCR4				V		V
IL6				V		V
IL2RG				V		V
IL18RAP				V		V		V
IL20RB				V
IL24				V		V
CSF1				V		V
TNFRSF14				V		V
TNFSF14				V		V
TNFRSF1A				V		V
TNFRSF1B				V		V		V
TNFRSF10A				V		V
IL10RB					V
IL6ST					V
CCL23						V
CCL20						V		V
CCL21						V
CXCR2						V
CXCL9						V
CXCR3						V
IL10RA						V
IL6R						V		V
IL2RB						V
LTBR						V
TNFRSF10D						V
PF4V1								V
+ 04512: ECM-receptor interaction	2.4	0.3	1.1	0.5	0.8	0.2	2.3	0.6
COL6A5	V		V
TNC	V
IBSP	V					V
RELN	V					V		V
FRAS1	V		V
ITGAV		V	V		V
HMMR		V			V
CD47		V	V		V
LAMA5			V		V		V
COL4A4			V		V
COL4A5			V		V
COL4A6			V
GP1BB			V		V
FN1			V		V		V
THBS4			V		V
CD36			V
ITGB8			V		V		V
ITGA1			V		V
ITGA2			V		V
LAMC3				V		V
LAMA4				V
LAMB3				V		V
LAMC2				V		V
COL1A1				V
COL1A2				V
COL2A1				V		V
COL4A2				V		V
COL6A2				V		V
COMP				V		V
HSPG2				V		V
CD44				V		V
AGRN				V		V
GP1BA					V
ITGB1					V
ITGB4					V		V
FREM2					V		V
LAMB4						V
FREM1						V
THBS3							V
THBS2								V
+ 4. Cellular Processes	3.1	6.3	4.5	6	6.8	3.8	3.4	2.3
+ 4.1 Transport and catabolism	0.5	2.9	3	3	4.1	1.9	1.9	0.6
+ 04144: Endocytosis	0	2.3	0.2	1.7	2.4	0.6	0.2	0
PARD6A	V
STAM2		V			V
USP8		V			V
VPS37A		V			V
PDCD6IP		V	V		V
RAB11FIP2		V			V
EEA1		V	V		V
ACAP2		V			V
ASAP3		V			V
SMAP1		V
TGFBR1		V
CAV1		V			V
CAV2		V	V		V
KIF5B		V			V
WASHC4		V			V
CAPZA2		V			V
SPART		V			V
VPS26A		V	V		V
WASL		V			V
LDLR			V		V
AP2A1			V		V
HSPA1L			V		V
DNAJC6			V		V
CHMP1B			V		V
VPS4A			V		V
VPS4B			V		V
CHMP5			V		V
ARF6			V		V
RAB5A			V		V
RAB5B			V		V
FGFR3			V
GRK4			V		V
GRK1			V		V		V
PLD1			V		V
ARFGEF1			V		V
PSD3			V		V
ARAP2			V		V
ARFGAP3			V		V
GIT1			V		V
ASAP2			V		V
CAPZA1			V		V
RAB10			V		V
RAB22A			V		V
RAB11FIP4			V
IST1			V		V
CBLC				V		V
SMURF1				V		V
SMURF2				V
CBLB				V		V
AP2M1				V		V
AP2S1				V		V
VPS37B				V		V
VPS36				V		V
VPS25				V		V
CHMP6				V		V
HRAS				V		V
SRC				V		V
RAB11B				V		V
EPN1				V		V
EPS15L1				V		V
RAB5C				V		V
CXCR1				V		V
CXCR4				V		V
EGFR				V
FGFR4				V		V	V
SH3GLB2				V		V
GRK2				V		V
GRK5				V		V
GRK6				V		V
ARRB1				V		V
RAB11FIP5				V		V
PIP5K1C				V		V
CYTH2				V		V
IQSEC1				V
AGAP3				V		V
ARFGAP1				V		V
SMAP2				V		V
ARFGAP2				V		V
ACAP1				V		V
HLA-F				V
SMAD3				V		V
IL2RG				V		V
ARF1				V		V
ARF3				V		V
ARF5				V		V
WASHC5				V
CAPZB				V		V
BIN1				V
ARPC4				V		V
ARPC1A				V
SNX12				V		V
SNX32				V		V
DNM3					V
WWP1					V
NEDD4L					V
ITCH					V
VPS37D					V		V
CHMP2B					V
PRKCI					V
SH3GLB1					V
ASAP1					V
ZFYVE16					V		V
SMAD2					V
SNX4					V
ARPC2					V
SNX2					V
WIPF1					V
DNM2						V
EPN2						V
CXCR2						V
FGFR2						V
ARAP1						V
RAB7A						V
IL2RB						V
CHMP7						V
WIPF3						V
SH3GL2								V
+ 04145: Phagosome	0	0.4	1.3	0.9	0.8	0.2	1.3	0.8
ITGAV		V	V		V
EEA1		V	V		V
DYNC1I2		V
LAMP2		V			V
MARCO		V		V
HLA-DPA1		V
FCGR2A			V		V
C1R			V
ITGB2			V		V		V
PLA2R1			V		V		V
MSR1			V		V
ITGA2			V		V
RAB5A			V		V
RAB5B			V		V
RAC1			V		V
DYNC1I1			V		V
DYNC1LI2			V		V
TUBA3E			V		V
TUBA1A			V		V
TUBB			V		V
TUBB8			V		V
TUBB2B			V
ATP6V1G3			V		V		V
ATP6V0D2			V		V		V
ATP6V1B1			V
PIKFYVE			V		V
CD36			V
THBS4			V		V
SEC61G			V		V
HLA-DMB			V		V
SEC22B				V
VAMP3				V
RAB5C				V		V
RAB7B				V		V
CYBA				V		V
NCF2				V		V
TUBA1C				V		V
TUBB6				V		V
TCIRG1				V		V
ATP6V1A				V		V
ATP6V0C				V		V
ATP6V0B				V		V
ATP6V0D1				V		V
CD14				V		V
SCARB1				V		V
C3				V		V		V
COMP				V		V
SFTPD				V		V
CALR				V		V
HLA-DRA				V
HLA-DRB5				V		V		V
CD209				V		V
TAP1				V
CTSL				V		V
HLA-F				V
ITGB1					V
ATP6V1C1					V
STX7					V
TAP2					V
RAB7A						V
M6PR						V
ATP6V0A1						V
ATP6V1F						V
COLEC11						V
HLA-DOB						V
CORO1A						V
TUBB4A							V
THBS3							V
THBS2								V
HLA-DPB1								V
+ 04142: Lysosome	0.1	0.3	0.4	1.6	0.9	1.1	0.5	0.7
CTSC	V
LAMP2		V			V
LAPTM5		V		V		V		V
CD164		V			V
AP1S2		V	V		V
ATP6V0D2			V		V		V
CTSK			V		V
CTSV			V		V			V
CTSO			V		V		V
CTSF			V		V
LGMN			V		V
ARSG			V		V
DNASE2B			V
AGA			V
GNPTAB			V		V
SCARB2			V		V
SLC11A2			V		V
AP1G1			V		V
AP3B1			V		V
GGA3			V
TCIRG1				V		V
ATP6V0C				V		V
ATP6V0B				V		V
ATP6V0D1				V		V
CTSD				V		V
CTSL				V		V
CTSW				V
TPP1				V
GLA				V		V
GBA				V		V
MAN2B1				V		V
GUSB				V		V
ARSA				V		V		V
ARSB				V		V
SGSH				V		V
PLA2G15				V		V
CD68				V		V
AP1M2				V		V
AP3D1				V		V
GGA1				V		V
ACP5				V		V
AP4B1				V		V
AP4M1				V		V
HYAL1				V		V
GNS					V
PSAPL1					V
SLC17A5					V
CLN5					V
MFSD8					V
AP4S1					V
AP4E1					V
MCOLN1					V
ATP6V0A1						V
GAA						V
NEU1						V
ACP2						V
M6PR						V
IDUA							V
+ 04146: Peroxisome	0.8	1.1	0.5	0.1	1	0.2	1	0
ACOX2	V
SLC27A2	V		V		V
AGPS		V			V
PECR		V		V
ACSL3		V	V		V		V
ACSL4		V			V
FAR1		V			V
PEX1			V		V
PHYH			V
HACL1			V		V
EHHADH			V		V
NUDT12			V		V
IDH1			V		V
IDH2			V		V
HAO1			V		V		V
FAR2			V		V
PEX14				V		V
PEX6				V		V
PEX16				V		V
ACOT8				V		V
ABCD1				V		V
ACSL1				V		V
GSTK1				V
SCP2					V
CROT					V
NUDT19					V
PEX10						V
MVK						V
PMVK						V
BAAT						V
ECI2						V
HAO2						V
MPV17						V
ECH1							V
+ 04140: Autophagy - animal	0.5	1.6	2.6	1.1	2.6	1.2	0.2	0.1
MTMR4	V		V		V
ATG16L2	V					V
PIK3CA		V	V		V
PIK3R1		V	V		V
PTEN		V	V		V
AKT3		V
RB1CC1		V	V		V
PRKACB		V			V
HMGB1		V	V		V
ATG5		V	V		V
LAMP2		V			V
IRS1			V		V
IRS2			V		V
KRAS			V		V
HIF1A			V		V
DDIT4			V		V		V
BNIP3			V		V
RPTOR			V
RPS6KB1			V		V
PPP2CB			V		V
ATG2B			V		V
RRAGB			V		V
RRAGA			V
PRKAA2			V		V
TP53INP2			V		V
NRBF2			V		V
ATG14			V		V
UVRAG			V		V
ATG12			V		V
RAB33B			V		V
GABARAPL2			V
GABARAPL1			V		V		V
VMP1			V		V
INS				V		V
PIK3R2				V		V
HRAS				V		V
RRAS				V		V
MAP2K2				V		V
MAPK1				V		V
TSC2				V		V
MTOR				V		V
RPS6KB2				V		V
ATG101				V		V
CAMKK2				V		V		V
PRKACG				V		V
AMBRA1				V		V
BCL2L1				V		V
ATG9B				V		V
MTMR14				V		V
BAD				V		V
DAPK2				V		V
ATG4D				V		V
RAB7B				V		V
VAMP8				V		V
CTSD				V		V
CTSL				V		V
ULK2					V
STX17					V
SH3GLB1					V
EIF2S1					V
ATG4C					V
MLST8						V
ATG13						V
STK11						V
PRKACA						V
ZFYVE1						V
RAB7A						V
+ 04136: Autophagy - other	0	0.3	1.4	0.3	1	0.4	0.6	0
ATG5		V	V		V
RPTOR			V
PPP2CB			V		V
ATG2B			V		V
GABARAPL2			V
GABARAPL1			V		V		V
ATG12			V		V
MTOR				V		V
ATG101				V		V
ATG9B				V		V
ATG4D				V		V
ULK2					V
ATG4C					V
MLST8						V
ATG13						V
+ 04137: Mitophagy - animal	0	1.8	1.7	2.3	2	1.4	1.2	0
USP8		V			V
TBK1		V			V
BNIP3L		V	V		V		V
ATG5		V	V		V
TAX1BP1		V			V
TBC1D15		V			V
MFN1			V		V
USP30			V
OPTN			V		V
NBR1			V		V
GABARAPL2			V
GABARAPL1			V		V		V
FUNDC1			V		V
BNIP3			V		V
TBC1D17			V		V		V
HIF1A			V		V
RELA			V
KRAS			V		V
MFN2				V		V
AMBRA1				V		V
SQSTM1				V		V
SRC				V		V
CSNK2A1				V		V
CSNK2B				V		V
BCL2L1				V		V
RHOT2				V		V
ATG9B				V		V
TFEB				V
TFE3				V		V
RAB7B				V		V
FIS1				V		V
E2F1				V		V
TP53				V		V
HRAS				V		V
RRAS				V		V
CALCOCO2					V
RHOT1					V
RAB7A						V
+ 4.2 Cell growth and death	2.2	4.3	2.1	5.2	3.4	3.6	1.4	2.2
+ 04110: Cell cycle	0.5	2	0.2	3	1.4	1.6	0.2	1.5
CCNA1	V		V		V		V
CCND2	V		V
ORC3		V			V
ORC4		V	V		V
CDK1		V			V
ATR		V			V
RB1		V			V
CCNE2		V			V			V
TTK		V			V
SMC3		V			V
STAG1		V			V
STAG2		V			V
ORC6			V		V
CDC27			V		V
ATM			V		V
MAD2L1			V		V
CREBBP			V		V
CDKN1B			V
CDKN1C			V		V		V
TGFB3			V		V
CCNH			V		V
E2F5			V		V
MYC			V		V
RBL2			V		V
MCM2				V		V
MCM3				V		V
MCM4				V		V
MCM5				V		V
MCM7				V
ORC1				V		V		V
BUB1B				V		V
PLK1				V		V
SFN				V		V
CHEK2				V
CDKN1A				V		V
PRKDC				V		V
PKMYT1				V		V
ESPL1				V		V
SMC1A				V		V
GADD45A				V		V
TP53				V		V
SMAD3				V		V
CDC20				V		V
CDC25B				V		V
CDC45				V		V		V
CDC25A				V		V		V
CDK2				V		V
CDK4				V		V
CCNE1				V		V
CCND3				V
MAD1L1				V		V
CDKN2C				V		V
RBL1				V
E2F4				V		V
ZBTB17				V		V
E2F1				V		V
CDC14A					V
WEE2					V
SMAD2					V
RAD21					V
ANAPC5						V
MAD2L2						V
SMC1B						V
SKP2								V
+ 04114: Oocyte meiosis	0	1.7	0.3	0.8	0.7	0.9	0	1.1
CDK1		V			V
RPS6KA3		V	V		V
FBXO5		V			V
CCNE2		V			V			V
CPEB4		V	V		V
PRKACB		V			V
PPP1CB		V			V
SMC3		V			V
SLK		V	V		V
MAD2L1			V		V
CDC27			V		V
FBXO43			V		V
CAMK2D			V		V
PLCZ1			V					V
ITPR2			V		V
CALM1			V		V
CALML4			V
PPP3CA			V		V
PPP3CC			V
CPEB2			V		V
PPP1CC			V		V
PPP2CB			V		V
MAD1L1				V		V
PKMYT1				V		V
RPS6KA2				V		V
MAPK1				V		V
CDC20				V		V
CCNE1				V		V
CDK2				V		V
CAMK2B				V
PLK1				V		V
CPEB1				V		V		V
PRKACG				V		V
ADCY1				V		V
ADCY2				V		V		V
PPP1CA				V		V
MAPK14				V
MAPK12				V		V
ESPL1				V		V
SMC1A				V		V
PGR				V		V
INS				V		V
IGF1				V		V
CPEB3					V
PPP2R5C					V
SPDYA					V
MAD2L2						V
RPS6KA1						V
ANAPC5						V
CALML3						V
PRKACA						V
MAPK11						V
MAPK13						V
SMC1B						V
+ 04210: Apoptosis	1.3	1.1	0.8	2.5	0.7	1.6	0.2	0.9
BCL2A1	V					V		V
FOS	V		V
CTSC	V
HRK	V		V		V
BIRC3		V			V			V
XIAP		V			V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
NGF		V		V
TNF		V		V		V		V
TNFSF10		V		V
ATM			V		V
RELA			V
APAF1			V		V
FADD			V		V
TNFRSF10B			V		V
FAS			V		V
BBC3			V		V		V
PTPN13			V		V
MAP3K5			V		V
CTSK			V		V
CTSV			V		V			V
CTSO			V		V		V
CTSF			V		V
ITPR2			V		V
TUBA3E			V		V
TUBA1A			V		V
KRAS			V		V
BCL2L1				V		V
DFFA				V		V
TP53				V		V
AIFM1				V		V
BIRC5				V		V
CASP3				V
BAD				V		V
NFKB1				V		V
CAPN1				V		V
PIK3R2				V		V
TRAF2				V		V
CSF2RB				V		V
TNFRSF1A				V		V
TNFRSF10A				V		V
LMNA				V		V
PARP2				V		V
BAX				V		V
GADD45A				V		V
TRAF1				V		V
CTSD				V		V
CTSL				V		V
CTSW				V
DDIT3				V		V
CASP2				V		V
PRF1				V		V
TUBA1C				V		V
HRAS				V		V
MAP2K2				V		V
MAPK1				V		V
CAPN2					V
PMAIP1					V
EIF2S1					V
ENDOG						V
FASLG						V
LMNB2						V
PARP3						V
BCL2L11						V
+ 04215: Apoptosis - multiple species	0	1.4	0.2	0.5	1.4	0.4	1.3	0.7
BIRC3		V			V			V
XIAP		V			V
NGFR		V			V		V
APAF1			V		V
FADD			V		V
BBC3			V		V		V
CASP3				V
BIRC5				V		V
BAX				V		V
BCL2L1				V		V
TNFRSF1A				V		V
BIRC6					V
PMAIP1					V
BOK						V
BCL2L11						V
+ 04216: Ferroptosis	0.7	1.7	1.2	1	1.5	0.8	0.5	0
SAT1	V		V
GCLM		V			V
ATG5		V	V		V
ACSL3		V	V		V		V
ACSL4		V			V
SLC7A11			V		V
VDAC2			V		V
SLC40A1			V		V
FTH1			V		V
SLC11A2			V		V
TP53				V		V
GCLC				V
SLC3A2				V		V
GSS				V		V
FTL				V		V
MAP1LC3A				V		V
SAT2				V		V
ACSL1				V		V
MAP1LC3B					V
SLC39A14						V
ALOX15						V
+ 04217: Necroptosis	1	0.5	0.2	2.3	0.1	2.1	0	1.4
CASP1	V		V
H2AFJ	V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
TNF		V		V		V		V
TNFSF10		V		V
BIRC3		V			V			V
XIAP		V			V
TRPM7		V	V		V
HMGB1		V	V		V
PYCARD		V		V		V
TNFRSF10B			V		V
FAS			V		V
TLR3			V		V
FADD			V		V
SLC25A4			V		V
DNM1L			V		V
FTH1			V		V
HIST2H2AC			V
CAMK2D			V		V
VPS4A			V		V
CHMP5			V		V
CHMP1B			V		V
VPS4B			V		V
VDAC2			V		V
TNFRSF1A				V		V
TRAF2				V		V
MLKL				V		V
JAK2				V		V
TYK2				V		V
TNFRSF10A				V		V
CYLD				V		V
TNFAIP3				V		V		V
FAF1				V		V
TICAM1				V		V
RBCK1				V		V
RNF31				V		V
SHARPIN				V		V
STAT3				V
STAT4				V		V
STAT5B				V		V
STAT6				V		V
IL1A				V		V
PYGM				V		V
SLC25A6				V		V
NLRP3				V		V		V
IL1B				V		V		V
FTL				V		V
CAPN1				V		V
H2AFX				V		V
HIST2H2AB				V		V		V
AIFM1				V		V
BAX				V		V
PARP2				V		V
PLA2G4D				V		V
CAMK2B				V
CHMP6				V		V
SQSTM1				V		V
IFNGR1					V
HSP90AA1					V
CAPN2					V
CHMP2B					V
IFNA6						V
IFNA14						V
IFNA21						V
JAK3						V
FASLG						V
PARP3						V
PLA2G4E						V
PLA2G4F						V
CHMP7						V
ALOX15						V
IL33							V
+ 04115: p53 signaling pathway	2.1	1.7	2.2	1.7	2.2	0.7	1.1	0.3
IGFBP3	V
SERPINB5	V		V				V
TP53I3	V
CCND2	V		V
ATR		V			V
CCNE2		V			V			V
RRM2B		V	V		V
PTEN		V	V		V
CD82		V		V		V
CDK1		V			V
SIAH1			V		V
ATM			V		V
PPM1D			V		V
CCNG1			V		V
CCNG2			V		V		V
FAS			V		V
TNFRSF10B			V		V
APAF1			V		V
RCHY1			V		V
PERP			V
SESN3			V		V
BBC3			V		V		V
GORAB			V		V
GADD45A				V		V
CHEK2				V
SFN				V		V
CDK2				V		V
CCNE1				V		V
TSC2				V		V
IGF1				V		V
CDKN1A				V		V
GTSE1				V		V
BAX				V		V
TP53				V		V
CDK4				V		V
CCND3				V
CASP3				V
BCL2L1				V		V
MDM4					V
PMAIP1					V
RRM2						V
SHISA5						V
+ 04218: Cellular senescence	0.6	2.2	0.9	2.9	1.5	2	0.6	0.4
CCND2	V		V
CCNA1	V		V		V		V
IGFBP3	V
PPP1CB		V			V
HIPK2		V		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
CCNE2		V			V			V
RB1		V			V
LIN9		V			V
ATR		V			V
CDK1		V			V
TRPM7		V	V		V
TGFBR1		V
PTEN		V	V		V
PPP1CC			V		V
MYC			V		V
KRAS			V		V
RBL2			V		V
E2F5			V		V
MAP2K6			V		V		V
ATM			V		V
RAD50			V		V
NBN			V		V
RELA			V
CALM1			V		V
CALML4			V
PPP3CA			V		V
PPP3CC			V
ITPR2			V		V
TRPV4			V		V		V
TGFB3			V		V
SLC25A4			V		V
VDAC2			V		V
PPP1CA				V		V
TP53				V		V
PIK3R2				V		V
TSC2				V		V
MTOR				V		V
HRAS				V		V
RRAS				V		V
MAP2K2				V		V
CDK4				V		V
CCND3				V
MAPK1				V		V
CDKN1A				V		V
CDK2				V		V
CCNE1				V		V
RBL1				V
E2F1				V		V
E2F4				V		V
MAPK14				V
MAPK12				V		V
MAP2K3				V		V
MYBL2				V		V
CHEK2				V
GADD45A				V		V
CDC25A				V		V		V
RAD9A				V		V
NFKB1				V		V
TRAF3IP2				V		V
SQSTM1				V		V
EIF4EBP1				V		V
IL1A				V		V
CAPN1				V		V
NFATC2				V		V
NFATC3				V		V
IL6				V		V
CXCL8				V		V		V
SMAD3				V		V
HLA-F				V
SLC25A6				V		V
SIRT1					V
RBBP4					V
RAD9B					V
MAPKAPK2					V
CAPN2					V
SMAD2					V
HIPK4						V
MAPK11						V
MAPK13						V
FOXM1						V
LIN37						V
RAD1						V
CACNA1D						V
CALML3						V
GATA4							V
+ 4.3 Cellular community - eukaryotes	2.8	3.6	2.7	2.1	3.8	1.2	1.8	1.3
+ 04510: Focal adhesion	1.1	2.7	1	1.5	1.4	0.3	2.2	0.8
COL6A5	V		V
TNC	V
IBSP	V					V
RELN	V					V		V
CCND2	V		V
ITGAV		V	V		V
PPP1R12A		V	V		V
PPP1CB		V			V
ROCK1		V	V		V
ROCK2		V			V
AKT3		V
PTEN		V	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
ARHGAP5		V	V		V		V
CAV1		V			V
CAV2		V	V		V
BIRC3		V			V			V
XIAP		V			V
MET		V			V
BUB1B-PAK6		V		V
PAK6		V		V
ITGB8			V		V		V
ITGA1			V		V
ITGA2			V		V
MYLK4			V		V
MYL12A			V		V
MYL5			V
PPP1CC			V		V
VCL			V		V
COL4A4			V		V
COL4A5			V		V
COL4A6			V
FN1			V		V		V
LAMA5			V		V		V
THBS4			V		V
KDR			V
PGF			V		V		V
PDGFC			V		V
PDGFD			V		V
SHC2			V		V		V
SHC4			V		V
RAC1			V		V
RAC3			V		V
MYLK2				V		V		V
MYL9				V
MYLPF				V		V
PPP1R12C				V		V
PPP1CA				V		V
PARVG				V		V
PIK3R2				V		V
ZYX				V		V
PIP5K1C				V		V
ACTN1				V		V
ARHGAP35				V		V
PRKCG				V		V
SRC				V		V
FYN				V
LAMC3				V		V
COL1A1				V
COL1A2				V
COL2A1				V		V
COL4A2				V		V
COL6A2				V		V
COMP				V		V
LAMA4				V
LAMB3				V		V
LAMC2				V		V
BAD				V		V
ELK1				V		V
MAPK1				V		V
CCND3				V
HRAS				V		V
GRB2				V		V
EGFR				V
FLT1				V		V
IGF1				V		V
PDGFA				V		V
SHC1				V		V
RAC2				V		V
ITGB1					V
ITGB4					V		V
CAPN2					V
SOS1					V
SOS2					V
RAP1A					V
CTNNB1					V
MYL7						V
PXN						V
LAMB4						V
EGF						V
PAK1						V
VAV1						V
THBS3							V
PDGFB							V
VEGFA							V
PARVB								V
THBS2								V
+ 04520: Adherens junction	2.1	1.7	0.9	0.9	2.2	0.3	0.2	0.3
LEF1	V					V
TCF7	V					V
WASF3	V							V
NECTIN1	V			V		V
YES1		V			V
FER		V			V
TGFBR1		V
MET		V			V
WASL		V			V
SSX2IP		V			V
CTNNA1			V		V
CTNND1			V		V
TCF7L2			V
TCF7L1			V		V
CREBBP			V		V
RAC1			V		V
RAC3			V		V
VCL			V		V
LMO7			V		V		V
IQGAP1			V		V
NECTIN3			V		V
FARP2			V		V
SMAD3				V		V
FYN				V
MAPK1				V		V
EGFR				V
INSR				V		V
CSNK2A1				V		V
CSNK2B				V		V
PTPN1				V		V
WASF2				V		V
RAC2				V		V
ACTN1				V		V
SRC				V		V
SMAD2					V
TJP1					V
CTNNB1					V
+ 04530: Tight junction	0.3	1	0.3	0.3	1.9	0.1	0.5	0.1
PARD6A	V
PPP2R2C	V		V
TIAM1		V
ROCK1		V	V		V
ROCK2		V			V
MICALL2		V
PRKACB		V			V
CLDN11		V			V
WASL		V			V
DLG1		V			V
MYH10		V			V
OCLN			V		V
RAC1			V		V
RAPGEF6			V		V
PPP2CB			V		V
MAP3K5			V		V
LLGL2			V		V		V
LLGL1			V		V
MPP4			V		V
MARVELD2			V		V
CLDN15			V		V
PRKAA2			V		V
TUBA3E			V		V
TUBA1A			V		V
WHAMM			V
ACTR2			V		V
JAM3			V		V
MYL12A			V		V
MYH14			V		V
PRKCE			V		V
CGNL1			V		V
ARHGAP17				V		V
ACTN1				V		V
PRKACG				V		V
SRC				V		V
MAP2K7				V		V
MSN				V		V
CLDN24				V		V
CLDN4				V
CLDN22				V		V
CLDN25				V
CLDN6				V		V
CLDN2				V
PRKAG3				V		V		V
PRKAG1				V		V
TJP2				V		V
TUBA1C				V		V
CDK4				V		V
ARHGEF2				V
CD1C				V		V
HCLS1				V		V
MYL9				V
MYL6B				V		V
MYH11				V		V
MYH7B				V		V
TJP1					V
PRKCI					V
MAGI1					V
RAP1A					V
MPDZ					V
RAPGEF2					V
CFTR					V
RAB8B					V
ITGB1					V
MPP5					V
NEDD4L					V
STK11						V
PRKACA						V
CACNA1D						V
YBX3						V
CLDN7						V
PRKAB1						V
SYMPK						V
TJP3						V
MYH13						V
CLDN10							V
CLDN8							V
GATA4							V
ACTR3B								V
+ 04540: Gap junction	0.8	0.3	1.5	0.6	1.4	0.3	0.4	0.6
GJA1	V		V					V
GRM5	V		V		V
MAP3K2		V			V
CDK1		V			V
PRKACB		V			V
GNAI3			V		V
PRKG1			V		V
PRKG2			V		V
TUBB			V		V
TUBB8			V		V
TUBB2B			V
TUBA3E			V		V
TUBA1A			V		V
KRAS			V		V
PDGFC			V		V
PDGFD			V		V
ADRB1			V		V
GNA11			V
PLCB1			V
ITPR2			V		V
PRKCG				V		V
PRKACG				V		V
TUBB6				V		V
ADCY1				V		V
ADCY2				V		V		V
SRC				V		V
TUBA1C				V		V
MAPK1				V		V
MAP2K2				V		V
HRAS				V		V
GRB2				V		V
EGFR				V
PDGFA				V		V
GRM1				V		V
TJP1					V
SOS1					V
SOS2					V
PRKACA						V
EGF						V
PLCB2						V
TUBB4A							V
PDGFB							V
+ 04550: Signaling pathways regulating pluripotency of stem cells	2.1	2.3	2.2	1.3	1.6	1.7	0.7	1.3
WNT10B	V					V
WNT5B	V					V
APC2	V		V		V
TCF7	V					V
INHBA	V			V		V		V
ID1	V					V
FZD7		V		V
LIFR		V	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
INHBB		V			V		V
BMP4		V					V
BMPR2		V	V		V
SMARCAD1		V	V		V
JARID2		V	V		V
RIF1		V			V
PCGF5		V	V		V
APC			V		V
DVL3			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
KLF4			V		V
INHBE			V		V
ACVR1C			V		V
BMPR1A			V		V
ACVR1			V		V
POU5F1			V		V
POU5F1B			V		V
SOX2			V		V
KRAS			V		V
FGFR3			V
SMAD1			V
SMAD9			V					V
MYC			V		V
HESX1			V		V
MEIS1			V
PCGF3			V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
AXIN1				V		V
DVL1				V		V
DVL2				V		V
LIF				V		V
JAK2				V		V
STAT3				V
PIK3R2				V		V
GRB2				V		V
SMAD3				V		V
MAPK1				V		V
HRAS				V		V
MAP2K2				V		V
FGFR4				V		V	V
IGF1				V		V
MAPK14				V
MAPK12				V		V
ID3				V		V		V
HOXB1				V		V
PCGF6				V
NODAL				V		V
CTNNB1					V
IL6ST					V
SMAD2					V
WNT4						V
WNT3A						V
JAK3						V
FGFR2						V
MAPK11						V
MAPK13						V
HAND1						V
ONECUT1						V
PCGF1						V
+ 4.5 Cell motility	0.7	1.7	1.1	1.6	2.2	0.9	1.7	0.4
+ 04810: Regulation of actin cytoskeleton	0.7	1.7	1.1	1.6	2.2	0.9	1.7	0.4
PFN2	V		V		V
APC2	V		V		V
CYFIP2	V					V		V
BDKRB1	V					V
WASL		V			V
NCKAP1		V	V		V
PPP1R12A		V	V		V
PPP1CB		V			V
DIAPH3		V			V
ROCK1		V	V		V
ROCK2		V			V
BUB1B-PAK6		V		V
PAK6		V		V
TIAM1		V
PIK3CA		V	V		V
PIK3R1		V	V		V
ITGAV		V	V		V
MYH10		V			V
TMSB4X			V		V
APC			V		V
SCIN			V		V
VCL			V		V
PIKFYVE			V		V
PPP1CC			V		V
MYL12A			V		V
MYL5			V
MYLK4			V		V
GIT1			V		V
RAC1			V		V
RAC3			V		V
IQGAP1			V		V
ITGA1			V		V
ITGA2			V		V
ITGB2			V		V		V
ITGB8			V		V		V
FN1			V		V		V
KRAS			V		V
GNA13			V		V
FGFR3			V
FGF20			V		V
PDGFC			V		V
PDGFD			V		V
FGF17			V		V
F2R			V		V
MYH14			V		V
ARPC4				V		V
ARPC1A				V
PFN3				V		V		V
PFN1				V		V
WASF2				V		V
NCKAP1L				V		V
CFL1				V		V		V
LIMK1				V
GSN				V			V
PIP5K1C				V		V
ACTN1				V		V
MSN				V		V
PPP1R12C				V		V
PPP1CA				V		V
MYL9				V
MYLPF				V		V
MYLK2				V		V		V
RAC2				V		V
ARHGEF1				V		V
ARHGAP35				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
PIK3R2				V		V
CHRM1				V		V
CHRM2				V		V
CHRM3				V		V
SRC				V		V
ITGAX				V		V
HRAS				V		V
RRAS				V		V
EGFR				V
FGFR4				V		V	V
PDGFA				V		V
INS				V		V
CXCR4				V		V
LPAR4				V		V
LPAR2				V		V
CXCL12				V
ARPC2					V
CFL2					V
ENAH					V
ARHGEF12					V
IQGAP2					V
ITGB1					V
ITGB4					V		V
SOS1					V
SOS2					V
LPAR5					V		V
PXN						V
MYL7						V
PAK1						V
IQGAP3						V
VAV1						V
ITGAL						V
FGFR2						V
EGF						V
FGF6						V
FGF8						V
FGF22						V
CHRM4							V
PDGFB							V
+ 5. Organismal Systems	7	6.4	4.8	8.9	3.4	9.7	4.4	5.9
+ 5.1 Immune system	4	3.8	2.1	7.2	1.7	6.9	2.5	6.8
+ 04640: Hematopoietic cell lineage	0	0.1	0.1	0.9	0	0.9	0	2.3
HLA-DPA1		V
TNF		V		V		V		V
ITGA1			V		V
ITGA2			V		V
GP1BB			V		V
CD36			V
IL4R			V		V
CD24			V		V
CD4			V		V
CD38			V
HLA-DMB			V		V
IL7			V		V
CD14				V		V
CR1				V		V
CD44				V		V
CD22				V		V
MME				V		V
CD8A				V		V
CD1C				V		V
FLT3				V
HLA-DRA				V
HLA-DRB5				V		V		V
CSF1				V		V
FLT3LG				V		V
IL11				V
IL6				V		V
IL1A				V		V
IL1B				V		V		V
GP1BA					V
KITLG					V
GYPA						V
ANPEP						V
IL6R						V		V
CD33						V
CD2						V
IL7R						V		V
HLA-DOB						V
HLA-DPB1								V
+ 04610: Complement and coagulation cascades	1.4	1.1	0.9	1.3	0.7	0.9	1.9	3.6
SERPIND1	V		V
SERPINB2	V			V		V		V
BDKRB1	V					V
TFPI		V			V
C4BPB		V		V		V
C2		V		V		V
CLU		V		V		V
CFD		V			V
F13A1			V		V		V
F2R			V		V
PLG			V		V
C1R			V
C1S			V		V
CFH			V		V		V
CD46			V		V
PROS1			V		V
F2RL2			V		V
F3			V		V
ITGB2			V		V		V
C3AR1			V		V
FGG				V		V		V
PLAT				V		V
C3				V		V		V
SERPING1				V		V
C6				V		V		V
THBD				V		V
SERPINA1				V		V		V
SERPINF2				V		V		V
CR1				V		V
PLAUR				V		V
PROCR				V		V
ITGAX				V		V
C5					V
MASP1						V
PLAU							V
F2RL3							V
FGB								V
SERPINA5								V
+ 04611: Platelet activation	1.4	1.7	1.7	1.4	1.6	0.9	0.2	1.5
APBB1IP	V		V
PIK3CG	V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
ROCK1		V	V		V
ROCK2		V			V
PPP1R12A		V	V		V
PPP1CB		V			V
PTGS1		V		V
PRKACB		V			V
ITPR2			V		V
F2R			V		V
PLCB1			V
ITGA2			V		V
PRKG1			V		V
PRKG2			V		V
GNA13			V		V
PPP1CC			V		V
MYL12A			V		V
MYLK4			V		V
GNAI3			V		V
TBXAS1			V		V		V
COL3A1			V
GP1BB			V		V
SNAP23			V		V
FCGR2A			V		V
PLCG2				V		V		V
ORAI1				V		V
PIK3R2				V		V
MAPK14				V
MAPK12				V		V
MAPK1				V		V
ARHGEF1				V		V
PPP1CA				V		V
MYLK2				V		V		V
ADCY1				V		V
ADCY2				V		V		V
PIK3R6				V		V
PLA2G4D				V		V
STIM1				V		V
PRKACG				V		V
COL1A1				V
COL1A2				V
FGG				V		V		V
LYN				V		V
FYN				V
VAMP8				V		V
SRC				V		V
ARHGAP35				V		V
ITGB1					V
RAP1A					V
ARHGEF12					V
GP1BA					V
PRKCI					V
PLCB2						V
MAPK11						V
MAPK13						V
PIK3R5						V
PLA2G4E						V
PLA2G4F						V
PRKACA						V
FERMT3						V
F2RL3							V
FGB								V
+ 04620: Toll-like receptor signaling pathway	0.2	1.3	0.2	2.1	0.1	2.6	0.1	0.8
FOS	V		V
CXCL11		V			V
TBK1		V			V
CCL5		V		V		V
AKT3		V
TNF		V		V		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
RAC1			V		V
FADD			V		V
CD80			V		V
LY96			V		V
TLR3			V		V
RELA			V
MAP2K6			V		V		V
IL12B			V		V
CTSK			V		V
IRAK1				V		V
MYD88				V		V
MAPK1				V		V
NFKB1				V		V
TRAF3				V		V
CD40				V		V
MAPK14				V
MAPK12				V		V
CXCL8				V		V		V
TIRAP				V		V
IL1B				V		V		V
IKBKE				V		V
IL6				V		V
IRF3				V		V
TLR9				V		V
TOLLIP				V		V
TICAM1				V		V
CD14				V		V
PIK3R2				V		V
MAP2K7				V		V
MAP2K3				V		V
MAP2K2				V		V
TLR5					V
IRF5						V
IFNA6						V
IFNA14						V
IFNA21						V
MAPK11						V
MAPK13						V
TAB1						V
CXCL9						V
TLR7						V
+ 04621: NOD-like receptor signaling pathway	2.5	2.5	0.6	2.3	0.5	2	0.2	3.1
CASP1	V		V
IL18	V		V		V
TRPV2	V		V
CASP4	V					V
CXCL1	V			V		V		V
CXCL2	V					V		V
CXCL3	V					V		V
CCL2	V			V		V		V
PYCARD		V		V		V
AIM2		V		V
TRPM7		V	V		V
TBK1		V			V
ERBIN		V	V		V
NEK7		V			V
GBP3		V			V
BIRC3		V			V			V
XIAP		V			V
ATG5		V	V		V
TANK		V			V
NAMPT		V			V
IFI16		V		V
TNF		V		V		V		V
CCL5		V		V		V
TAB3			V		V
CARD8			V		V
SUGT1			V		V
PSTPIP1			V		V
NAIP			V		V
RELA			V
NLRP12			V
ITPR2			V		V
PLCB1			V
GBP2			V		V		V
VDAC2			V		V
GBP1			V		V
GABARAPL2			V
GABARAPL1			V		V		V
ATG12			V		V
CARD6			V		V
FADD			V		V
MFN1			V		V
DNM1L			V		V
OAS3			V		V
NOD2				V		V
NLRP3				V		V		V
IL1B				V		V		V
MAPK1				V		V
MAPK14				V
MAPK12				V		V
PANX1				V		V
NFKB1				V		V
TRAF3				V		V
IKBKE				V		V
IRF3				V		V
TYK2				V		V
GSDMD				V		V
MYD88				V		V
TICAM1				V		V
GBP7				V		V		V
TXN2				V		V
RBCK1				V		V
RNF31				V		V
SHARPIN				V		V
CYBA				V		V
NLRP6				V		V
TNFAIP3				V		V		V
TRIP6				V		V
TRAF2				V		V
CARD18				V		V
BCL2L1				V		V
MFN2				V		V
OAS1				V
OAS2				V
IL6				V		V
CXCL8				V		V		V
HSP90AA1					V
BRCC3					V
TAB1						V
MAPK11						V
MAPK13						V
PLCB2						V
IFNA6						V
IFNA14						V
IFNA21						V
NFKBIB						V
NLRP7						V
TMEM173							V
+ 04622: RIG-I-like receptor signaling pathway	0	1.7	0.4	0.8	0.4	1.4	1.1	0.7
IFIH1		V			V
TANK		V			V
TBK1		V			V
ATG5		V	V		V
SIKE1		V	V		V
TNF		V		V		V		V
DDX58			V		V		V
RNF125			V		V
RELA			V
FADD			V		V
ATG12			V		V
TKFC			V
IL12B			V		V
NFKB1				V		V
OTUD5				V		V
TRAF3				V		V
IRF3				V		V
IKBKE				V		V
CYLD				V		V
PIN1				V		V
MAPK14				V
MAPK12				V		V
TRAF2				V		V
CXCL8				V		V		V
AZI2					V
IFNA6						V
IFNA14						V
IFNA21						V
NFKBIB						V
MAPK11						V
MAPK13						V
IFNK						V	V
TMEM173							V
+ 04623: Cytosolic DNA-sensing pathway	1	1	0	1.6	0	1.8	1.2	0.8
CASP1	V		V
IL18	V		V		V
PYCARD		V		V		V
AIM2		V		V
TBK1		V			V
CCL5		V		V		V
RELA			V
DDX58			V		V		V
POLR3F			V		V
IL1B				V		V		V
IKBKE				V		V
IRF3				V		V
NFKB1				V		V
IL6				V		V
POLR3K				V		V
POLR2F				V		V
POLR2L				V		V
POLR3B				V		V
POLR1C				V		V
CGAS				V
IFNA6						V
IFNA14						V
IFNA21						V
NFKBIB						V
POLR3D						V
TREX1						V
TMEM173							V
IL33							V
POLR3G								V
+ 04625: C-type lectin receptor signaling pathway	1.6	0.7	0.6	2.3	0.1	2	0	1.3
CASP1	V		V
CLEC1B	V		V		V
PTGS2	V		V		V
EGR2	V		V
PYCARD		V		V		V
TNF		V		V		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
KRAS			V		V
RELA			V
IL12B			V		V
BCL3			V		V
PPP3CA			V		V
PPP3CC			V
ITPR2			V		V
CALM1			V		V
CALML4			V
CD209				V		V
KSR1				V		V
SRC				V		V
NFKB1				V		V
HRAS				V		V
RRAS				V		V
IL23A				V		V
NLRP3				V		V		V
IL1B				V		V		V
IL6				V		V
CYLD				V		V
IKBKE				V		V
PLCG2				V		V		V
MAPK1				V		V
NFATC2				V		V
NFATC3				V		V
CBLB				V		V
PIK3R2				V		V
NFKB2				V		V
RELB				V		V
CCL17				V		V
MAPK14				V
MAPK12				V		V
ARHGEF12					V
MAPKAPK2					V
PAK1						V
CALML3						V
EGR3						V
MAPK11						V
MAPK13						V
+ 04650: Natural killer cell mediated cytotoxicity	0.1	0.2	0.4	0.7	0.3	0.7	1.2	0.3
ICAM2	V					V
TNFSF10		V		V
TNF		V		V		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PPP3CA			V		V
PPP3CC			V
PLCG1			V		V
CD247			V		V
FAS			V		V
TNFRSF10B			V		V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
RAC1			V		V
RAC3			V		V
KLRC2			V		V		V
KLRC3			V		V		V
ITGB2			V		V		V
KLRC1			V		V		V
NFATC2				V		V
FYN				V
PLCG2				V		V		V
PRF1				V		V
PRKCG				V		V
PTK2B				V		V
CASP3				V
TNFRSF10A				V		V
ULBP3				V		V
ULBP2				V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
GRB2				V		V
SHC1				V		V
RAC2				V		V
NCR2				V		V
IFNGR1					V
SH3BP2					V
SOS1					V
SOS2					V
IFNA6						V
IFNA14						V
IFNA21						V
PAK1						V
VAV1						V
FASLG						V
NCR3						V
ITGAL						V
RAET1L						V
+ 04612: Antigen processing and presentation	0	0.4	0.1	0.6	0.3	0.1	1.5	1.2
CREB1		V			V
HLA-DPA1		V
TNF		V		V		V		V
HLA-DMB			V		V
NFYB			V		V
LGMN			V		V
CD4			V		V
KLRC1			V		V		V
KLRC2			V		V		V
KLRC3			V		V		V
HSPA1L			V		V
CD74				V
NFYC				V		V
CIITA				V		V
CTSL				V		V
IFI30				V		V
CD8A				V		V
CALR				V		V
HLA-F				V
HLA-DRA				V
HLA-DRB5				V		V		V
TAP1				V
TAP2					V
HSP90AA1					V
RFXANK						V
HLA-DOB						V
PSME3						V
KLRC4							V
HLA-DPB1								V
+ 04660: T cell receptor signaling pathway	0.2	1.4	0.7	1.4	0.3	0.7	0.1	0.4
FOS	V		V
TNF		V		V		V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
BUB1B-PAK6		V		V
PAK6		V		V
DLG1		V			V
RELA			V
CD28			V		V
KRAS			V		V
PPP3CA			V		V
PPP3CC			V
TEC			V		V
PLCG1			V		V
GRAP2			V		V		V
NCK1			V		V
CD247			V		V
CD4			V		V
PTPRC			V		V
CDK4				V		V
NFKBIE				V		V		V
NFKB1				V		V
CARD11				V		V
GRB2				V		V
PIK3R2				V		V
HRAS				V		V
NFATC2				V		V
NFATC3				V		V
FYN				V
CD8A				V		V
CBLB				V		V
MAP2K2				V		V
MAPK1				V		V
MAP2K7				V		V
MAPK14				V
MAPK12				V		V
SOS1					V
SOS2					V
NFKBIB						V
VAV1						V
PAK1						V
MAPK11						V
MAPK13						V
+ 04658: Th1 and Th2 cell differentiation	0.3	0	0.4	1.3	0.1	1.8	0	1
FOS	V		V
HLA-DPA1		V
RELA			V
PPP3CA			V		V
PPP3CC			V
CD247			V		V
PLCG1			V		V
CD4			V		V
IL12B			V		V
IL4R			V		V
NOTCH2			V		V
NOTCH3			V		V
HLA-DMB			V		V
NFKBIE				V		V		V
NFKB1				V		V
NFATC2				V		V
NFATC3				V		V
MAPK1				V		V
MAPK14				V
MAPK12				V		V
STAT4				V		V
STAT6				V		V
IL2RG				V		V
STAT5B				V		V
NOTCH1				V		V
MAML1				V		V
DLL4				V		V
HLA-DRA				V
HLA-DRB5				V		V		V
JAK2				V		V
TYK2				V		V
IFNGR1					V
GATA3					V
NFKBIB						V
MAPK11						V
MAPK13						V
IL13						V
IL2RB						V
DLL3						V
DLL1						V
HLA-DOB						V
JAK3						V
HLA-DPB1								V
+ 04659: Th17 cell differentiation	0.2	0.1	0.1	1.6	0.1	1.7	0	1.7
FOS	V		V
HLA-DPA1		V
TGFBR1		V
RELA			V
PPP3CA			V		V
PPP3CC			V
PLCG1			V		V
CD4			V		V
IL4R			V		V
HLA-DMB			V		V
IL1RAP			V		V
CD247			V		V
HIF1A			V		V
NFKBIE				V		V		V
NFKB1				V		V
NFATC2				V		V
NFATC3				V		V
MAPK1				V		V
MAPK14				V
MAPK12				V		V
IL2RG				V		V
STAT6				V		V
STAT5B				V		V
HLA-DRA				V
HLA-DRB5				V		V		V
STAT3				V
MTOR				V		V
IL17A				V		V
RXRB				V		V
SMAD3				V		V
IL1B				V		V		V
IL6				V		V
IL23A				V		V
JAK2				V		V
TYK2				V		V
IFNGR1					V
IL6ST					V
GATA3					V
SMAD2					V
HSP90AA1					V
AHR					V
NFKBIB						V
MAPK11						V
MAPK13						V
IL2RB						V
HLA-DOB						V
IL6R						V		V
IL17F						V
IRF4						V
JAK3						V
HLA-DPB1								V
+ 04657: IL-17 signaling pathway	4.1	0.3	0.1	2.6	0	3.5	0	4.9
FOS	V		V
FOSB	V
CXCL1	V			V		V		V
CXCL2	V					V		V
CXCL3	V					V		V
CCL2	V			V		V		V
MMP1	V		V			V		V
MMP3	V					V		V
PTGS2	V		V		V
MAPK6		V
TBK1		V			V
TNF		V		V		V		V
TAB3			V		V
RELA			V
JUND			V
IL17B			V		V
FADD			V		V
MMP13			V
USP25			V		V
IL6				V		V
NFKB1				V		V
FOSL1				V		V
IL17A				V		V
IL17RE				V
TRAF3IP2				V		V
TRAF3				V		V
TRAF2				V		V
IKBKE				V		V
MAPK14				V
MAPK1				V		V
MAPK12				V		V
CASP3				V
MMP9				V		V
CCL17				V		V
TNFAIP3				V		V		V
CXCL8				V		V		V
CCL11				V		V
LCN2				V		V		V
TRAF4				V		V
IL1B				V		V		V
HSP90AA1					V
HSP90B1					V
SRSF1					V
IL25						V
IL17F						V
MAPK11						V
MAPK13						V
CCL20						V		V
MUC5AC						V
IL13						V
ANAPC5						V
+ 04662: B cell receptor signaling pathway	0.8	0.4	0.3	1.5	0	1.5	0.5	1.1
FOS	V		V
PIK3AP1	V		V					V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
RELA			V
KRAS			V		V
PPP3CA			V		V
PPP3CC			V
RAC1			V		V
RAC3			V		V
NFKBIE				V		V		V
NFKB1				V		V
CARD11				V		V
PIK3R2				V		V
INPPL1				V		V
HRAS				V		V
NFATC2				V		V
NFATC3				V		V
RAC2				V		V
PLCG2				V		V		V
LYN				V		V
CD22				V		V
LILRB5				V		V
MAP2K2				V		V
MAPK1				V		V
GRB2				V		V
DAPP1				V		V
SOS1					V
SOS2					V
NFKBIB						V
VAV1						V
CD79A						V
LILRA4						V
IFITM1							V
INPP5D							V
+ 04664: Fc epsilon RI signaling pathway	1	1.4	0.6	2.2	0.3	2	0.7	1.3
PLA2G4A	V		V		V
PLA2G4C	V		V
TNF		V		V		V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
ALOX5		V		V
MAP2K6			V		V		V
GAB2			V
PLCG1			V		V
KRAS			V		V
RAC1			V		V
RAC3			V		V
FYN				V
MAPK14				V
MAPK12				V		V
MAP2K7				V		V
MAP2K3				V		V
PIK3R2				V		V
LYN				V		V
PLCG2				V		V		V
MAPK1				V		V
MAP2K2				V		V
HRAS				V		V
GRB2				V		V
PLA2G4D				V		V
RAC2				V		V
ALOX5AP				V		V
SOS1					V
SOS2					V
IL13						V
MAPK11						V
MAPK13						V
PLA2G4E						V
PLA2G4F						V
VAV1						V
INPP5D							V
MS4A2								V
+ 04666: Fc gamma R-mediated phagocytosis	1.8	0.9	1.1	1.5	1.6	1	0.8	1.4
PLA2G4A	V		V		V
PLA2G4C	V		V
WASF3	V							V
SPHK1	V			V		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
WASL		V			V
ASAP3		V			V
FCGR2A			V		V
PTPRC			V		V
PLCG1			V		V
PRKCE			V		V
RPS6KB1			V		V
RAC1			V		V
PLD1			V		V
ASAP2			V		V
MARCKSL1			V		V		V
SCIN			V		V
GAB2			V
ARF6			V		V
HCK				V		V
LYN				V		V
PIK3R2				V		V
INPPL1				V		V
PLCG2				V		V		V
MAPK1				V		V
PLA2G4D				V		V
RPS6KB2				V		V
RAC2				V		V
WASF2				V		V
ARPC4				V		V
ARPC1A				V
LIMK1				V
CFL1				V		V		V
GSN				V			V
PIP5K1C				V		V
BIN1				V
PRKCG				V		V
ARPC2					V
DOCK2					V
CFL2					V
ASAP1					V
MARCKS					V
PLA2G4E						V
PLA2G4F						V
VAV1						V
PAK1						V
PLPP2						V
DNM2						V
INPP5D							V
+ 04670: Leukocyte transendothelial migration	0.2	0.9	1.1	2.2	1.3	1.3	1.4	0.1
ESAM	V
CLDN11		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
ROCK1		V	V		V
ROCK2		V			V
ARHGAP5		V	V		V		V
OCLN			V		V
CLDN15			V		V
PECAM1			V		V
ITGB2			V		V		V
CTNND1			V		V
MYL12A			V		V
MYL5			V
JAM3			V		V
CTNNA1			V		V
RAC1			V		V
RAPGEF4			V		V		V
TXK			V		V
GNAI3			V		V
PLCG1			V		V
VCL			V		V
CLDN24				V		V
CLDN4				V
CLDN22				V		V
CLDN25				V
CLDN6				V		V
CLDN2				V
MMP2				V		V
MMP9				V		V
CDH5				V		V
SIPA1				V		V
PIK3R2				V		V
MYL9				V
MYLPF				V		V
PRKCG				V		V
MAPK14				V
MAPK12				V		V
ARHGAP35				V		V
CYBA				V		V
NCF2				V		V
RAC2				V		V
MSN				V		V
PTK2B				V		V
CXCL12				V
CXCR4				V		V
PLCG2				V		V		V
ACTN1				V		V
ITGB1					V
CTNNB1					V
RAP1A					V
CLDN7						V
ITGAL						V
MYL7						V
MAPK11						V
MAPK13						V
PXN						V
VAV1						V
CLDN10							V
CLDN8							V
+ 04672: Intestinal immune network for IgA production	0	0.1	0.1	0.9	0	0.6	0	1.1
HLA-DPA1		V
CD80			V		V
CD28			V		V
HLA-DMB			V		V
CCR10			V
IL6				V		V
TNFSF13B				V
CD40				V		V
HLA-DRA				V
HLA-DRB5				V		V		V
MADCAM1				V		V
CXCL12				V
CXCR4				V		V
IL15RA				V		V
TNFRSF13C						V
TNFRSF13B						V
HLA-DOB						V
LTBR						V
HLA-DPB1								V
+ 04062: Chemokine signaling pathway	1.2	1	0	3	0	3.5	0.2	1.9
CXCL1	V			V		V		V
CXCL2	V					V		V
CXCL3	V					V		V
CCL2	V			V		V		V
PIK3CG	V		V
CCL5		V		V		V
CXCL11		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
ROCK1		V	V		V
ROCK2		V			V
WASL		V			V
TIAM1		V
PRKACB		V			V
AKT3		V
CCR4			V
CCR6			V		V
CCR10			V
PLCB1			V
SHC2			V		V		V
SHC4			V		V
GNAI3			V		V
GNG2			V		V
GRK4			V		V
GRK1			V		V		V
KRAS			V		V
RAC1			V		V
RAC3			V		V
RELA			V
CXCR1				V		V
CXCR4				V		V
CXCL8				V		V		V
PPBP				V		V
CXCL16				V		V
CCL11				V		V
CCL14				V		V
CCL15				V		V
CCL16				V		V
CCL17				V		V
CXCL12				V
JAK2				V		V
FGR				V		V
HCK				V		V
LYN				V		V
SRC				V		V
PIK3R2				V		V
SHC1				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
GRB2				V		V
GRK2				V		V
GRK5				V		V
GRK6				V		V
ARRB1				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
PTK2B				V		V
STAT3				V
STAT5B				V		V
MAPK1				V		V
HRAS				V		V
RAC2				V		V
NFKB1				V		V
BAD				V		V
PIK3R6				V		V
GNG10					V
RAP1A					V
DOCK2					V
SOS1					V
SOS2					V
CXCR3						V
CXCR2						V
CXCL9						V
CCL20						V		V
CCL21						V
CCL23						V
JAK3						V
PXN						V
PLCB2						V
GNB3						V
VAV1						V
PRKACA						V
PAK1						V
NFKBIB						V
PIK3R5						V
PF4V1								V
+ 5.2 Endocrine system	4.6	4.5	3.1	4.9	1.8	5.1	2.2	3.5
+ 04911: Insulin secretion	2.4	1.3	0.5	0.3	0.3	0.4	0.9	0.2
ATP1A3	V			V		V
RIMS2	V		V		V
SNAP25	V		V		V
KCNU1	V		V
KCNN2	V		V		V
PRKACB		V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
RAB3A		V			V
PLCB1			V
GNA11			V
CAMK2D			V		V
RAPGEF4			V		V		V
PCLO			V
KCNMB3			V		V
KCNMB1			V		V
KCNN4			V		V		V
CACNA1F				V		V
CHRM3				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
INS				V		V
PRKCG				V		V
CAMK2B				V
STX1A				V		V
ADCYAP1				V		V
CACNA1D						V
PLCB2						V
PRKACA						V
FFAR1						V
ATP1A4						V
CCK						V
ATP1B2							V
+ 04910: Insulin signaling pathway	0.4	0.3	1.1	2.5	0.7	1.9	0.2	0.2
PPP1R3B	V		V
G6PC3	V					V
PPP1CB		V			V
PRKACB		V			V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
SOCS4			V		V
SOCS2			V		V
MKNK2			V		V
FASN			V
PRKAA2			V		V
PPP1CC			V		V
PKLR			V		V
GYS2			V
CALM1			V		V
CALML4			V
PRKAR1A			V		V
RPTOR			V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
RPS6KB1			V		V
RHOQ			V		V
SH2B2			V
IRS1			V		V
IRS2			V		V
INPPL1				V		V
PTPN1				V		V
SOCS1				V		V
ELK1				V		V
MAPK1				V		V
PRKAG3				V		V		V
PRKAG1				V		V
INS				V		V
LIPE				V		V
PPP1CA				V		V
PHKG2				V
PRKACG				V		V
PRKAR1B				V		V
PRKAR2A				V		V
EIF4EBP1				V		V
PYGM				V		V
HRAS				V		V
EIF4E1B				V		V	V
MAP2K2				V		V
SHC1				V		V
INSR				V		V
RPS6KB2				V		V
GRB2				V		V
BAD				V		V
TSC2				V		V
ARAF				V		V
G6PC2				V		V
MTOR				V		V
PIK3R2				V		V
CBLB				V		V
FLOT1				V		V
FLOT2				V		V
PPP1R3C					V
PHKB					V
SOS1					V
SOS2					V
PRKCI					V
PRKAB1						V
CALML3						V
PRKACA						V
EXOC7						V
PDE3B								V
+ 04922: Glucagon signaling pathway	0.6	1	0.2	0.3	0.1	0.2	0	1.3
G6PC3	V					V
CPT1C	V		V
PRKACB		V			V
CREB1		V			V
ATF2		V			V
CREB5		V			V
PPP4R3B		V	V		V
AKT3		V
GYS2			V
PLCB1			V
CREBBP			V		V
CALM1			V		V
CALML4			V
PPP3CA			V		V
PPP3CC			V
PRKAA2			V		V
CAMK2D			V		V
ITPR2			V		V
PDHA1				V
PDHA2				V		V
PFKL				V		V
GCGR				V		V		V
ADCY2				V		V		V
PRKACG				V		V
PYGM				V		V
PPP4C				V		V
G6PC2				V		V
PHKG2				V
PFKFB1				V		V
PRKAG3				V		V		V
PRKAG1				V		V
CAMK2B				V
PHKB					V
SIRT1					V
PGAM2						V
PRKACA						V
PLCB2						V
CALML3						V
PRKAB1						V
PDE3B								V
+ 04923: Regulation of lipolysis in adipocytes	0.5	1.7	2	1.2	1.5	0.8	1.4	1.6
PTGS2	V		V		V
PRKACB		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
PTGS1		V		V
AKT3		V
ADRB1			V		V
NPR1			V				V
PRKG1			V		V
PRKG2			V		V
PLIN1			V		V
GNAI3			V		V
IRS1			V		V
IRS2			V		V
FABP4			V		V
NPY1R			V		V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
ADRB3				V		V		V
LIPE				V		V
AQP7				V		V
PNPLA2				V		V
INS				V		V
INSR				V		V
PIK3R2				V		V
PRKACA						V
NPPA						V
ADORA1							V
PDE3B								V
+ 04920: Adipocytokine signaling pathway	1	1.3	0.2	1.8	0	2.2	0.2	2.4
CPT1C	V		V
G6PC3	V					V
ACSL3		V	V		V		V
ACSL4		V			V
LEPR		V	V		V
AKT3		V
TNF		V		V		V		V
RELA			V
PRKAA2			V		V
IRS1			V		V
IRS2			V		V
CD36			V
NFKB1				V		V
NFKBIE				V		V		V
G6PC2				V		V
ACSL1				V		V
PRKAG3				V		V		V
PRKAG1				V		V
ADIPOR1				V		V
CAMKK2				V		V		V
RXRB				V		V
TNFRSF1B				V		V		V
STAT3				V
MTOR				V		V
TRAF2				V		V
TNFRSF1A				V		V
JAK2				V		V
NFKBIB						V
ACSBG1						V
LEP						V
PRKAB1						V
STK11						V
+ 03320: PPAR signaling pathway	2.6	0.8	0.8	0.2	0.8	0.3	1	0.7
SLC27A2	V		V		V
CPT1C	V		V
MMP1	V		V			V		V
ANGPTL4	V					V
ACOX2	V
ACADM		V			V
ACSL3		V	V		V		V
ACSL4		V			V
ME1		V			V
PLIN1			V		V
CD36			V
FABP4			V		V
FABP5			V		V
EHHADH			V		V
HMGCS1			V		V		V
SCD			V		V		V
DBI			V		V
AQP7				V		V
GK				V
PLIN5				V		V
SLC27A4				V		V
FABP6				V		V		V
RXRB				V		V
PPARD				V		V
ACSL1				V		V
PLTP				V		V
FABP2					V
SCP2					V
ACSBG1						V
APOC3						V
APOA1						V
+ 04912: GnRH signaling pathway	1.2	0.1	0.5	1.7	0.1	2.2	0.1	0.2
PLA2G4A	V		V		V
PLA2G4C	V		V
EGR1	V		V
MAP3K2		V			V
PRKACB		V			V
PLCB1			V
CAMK2D			V		V
MAP2K6			V		V		V
ITPR2			V		V
CALM1			V		V
CALML4			V
GNA11			V
PLD1			V		V
GNRH1			V		V
KRAS			V		V
ADCY1				V		V
ADCY2				V		V		V
CAMK2B				V
MAP2K3				V		V
MAPK14				V
MAPK12				V		V
PLA2G4D				V		V
SRC				V		V
MMP2				V		V
PRKACG				V		V
CACNA1F				V		V
ELK1				V		V
MAPK1				V		V
FSHB				V		V
MAP2K2				V		V
HRAS				V		V
GRB2				V		V
EGFR				V
PTK2B				V		V
MAP2K7				V		V
SOS1					V
SOS2					V
LHB						V
PLCB2						V
MAPK11						V
MAPK13						V
PLA2G4E						V
PLA2G4F						V
CALML3						V
GNRH2						V
PRKACA						V
CACNA1D						V
+ 04913: Ovarian steroidogenesis	3.2	1.4	0.2	1.8	0.1	1.9	0.4	1.1
ACOT2	V
CYP2J2	V					V
PTGS2	V		V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
AKR1C3		V
CYP1B1		V		V
PRKACB		V			V
ALOX5		V		V
HSD17B7			V		V		V
LDLR			V		V
CYP11A1				V		V		V
ADCY1				V		V
ADCY2				V		V		V
FSHB				V		V
PRKACG				V		V
INS				V		V
INSR				V		V
IGF1				V		V
PLA2G4D				V		V
SCARB1				V		V
LHB						V
PRKACA						V
PLA2G4E						V
PLA2G4F						V
+ 04915: Estrogen signaling pathway	0.1	1.1	0.2	1.1	0.2	0.9	0	0.1
FOS	V		V
PRKACB		V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
ESR2			V		V
KRAS			V		V
PLCB1			V
SHC2			V		V		V
SHC4			V		V
HSPA1L			V		V
GNAI3			V		V
ITPR2			V		V
CALM1			V		V
CALML4			V
NCOA3			V		V
KRT15			V
TGFA			V		V
GPER1				V
SRC				V		V
MMP2				V		V
MMP9				V		V
EGFR				V
PRKACG				V		V
HRAS				V		V
MAP2K2				V		V
MAPK1				V		V
ADCY1				V		V
ADCY2				V		V		V
KCNJ9				V		V
GABBR2				V		V
PIK3R2				V		V
SHC1				V		V
GRB2				V		V
GRM1				V		V
KRT25				V		V
KRT23				V		V
KRT9				V		V
KRT13				V		V
KRT14				V		V
CTSD				V		V
PGR				V		V
SOS1					V
SOS2					V
HSP90AA1					V
HSP90B1					V
PRKACA						V
PLCB2						V
CALML3						V
OPRM1						V
KRT12						V
KRT16						V
KRT33B						V
KRT35						V
+ 04914: Progesterone-mediated oocyte maturation	0.2	1.5	0.1	1.4	0.4	1.5	0.1	1.4
CCNA1	V		V		V		V
CPEB4		V	V		V
CDK1		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
PRKACB		V			V
RPS6KA3		V	V		V
CPEB2			V		V
KRAS			V		V
CDC27			V		V
MAD2L1			V		V
GNAI3			V		V
IGF1				V		V
INS				V		V
CPEB1				V		V		V
ADCY1				V		V
ADCY2				V		V		V
PIK3R2				V		V
MAD1L1				V		V
CDC25A				V		V		V
CDC25B				V		V
PLK1				V		V
PRKACG				V		V
PKMYT1				V		V
RPS6KA2				V		V
MAPK1				V		V
CDK2				V		V
MAPK14				V
MAPK12				V		V
PGR				V		V
ARAF				V		V
CPEB3					V
HSP90AA1					V
SPDYA					V
ANAPC5						V
MAD2L2						V
PRKACA						V
RPS6KA1						V
MAPK11						V
MAPK13						V
PDE3B								V
+ 04917: Prolactin signaling pathway	1.6	0.5	1.5	2	0.8	1.9	0.2	0.3
CCND2	V		V
FOS	V		V
TNFRSF11A	V					V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
KRAS			V		V
PRLR			V		V
SHC2			V		V		V
SHC4			V		V
SOCS4			V		V
SOCS2			V		V
SOCS6			V		V
SOCS5			V		V
ESR2			V		V
RELA			V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
HRAS				V		V
PRL				V		V		V
JAK2				V		V
STAT3				V
STAT5B				V		V
SHC1				V		V
SRC				V		V
GRB2				V		V
MAPK14				V
MAPK12				V		V
SOCS1				V		V
CISH				V		V
INS				V		V
NFKB1				V		V
SOS1					V
SOS2					V
MAPK11						V
MAPK13						V
TNFSF11						V
LHB						V
+ 04921: Oxytocin signaling pathway	2	0.4	1	1.5	0.1	1.6	0.3	1.5
PLA2G4A	V		V		V
PLA2G4C	V		V
PTGS2	V		V		V
RGS2	V		V
FOS	V		V
PIK3CG	V		V
PRKACB		V			V
OXTR		V	V		V
ROCK1		V	V		V
ROCK2		V			V
PPP1R12A		V	V		V
PPP1CB		V			V
MYLK4			V		V
ITPR2			V		V
CALM1			V		V
CALML4			V
PLCB1			V
KRAS			V		V
CAMK2D			V		V
PPP1CC			V		V
CACNA2D4			V		V
NPR1			V				V
PRKAA2			V		V
PPP3CA			V		V
PPP3CC			V
MEF2C			V		V		V
CD38			V
GNAI3			V		V
MYLK2				V		V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
PRKCG				V		V
HRAS				V		V
MAP2K2				V		V
MAPK1				V		V
PLA2G4D				V		V
EEF2				V		V
CAMK4				V
CAMK2B				V
CAMK1				V		V
MYL9				V
MYL6B				V		V
PPP1R12C				V		V
PPP1CA				V		V
CACNG3				V		V		V
CACNA1F				V		V
CAMKK2				V		V		V
PRKAG3				V		V		V
PRKAG1				V		V
NFATC2				V		V
NFATC3				V		V
ELK1				V		V
PIK3R6				V		V
SRC				V		V
EGFR				V
CDKN1A				V		V
KCNJ9				V		V
CACNB4					V
CALML3						V
PRKACA						V
PLCB2						V
PLA2G4E						V
PLA2G4F						V
CACNG2						V
CACNA2D3						V
CACNA1D						V
NPR2						V
PRKAB1						V
PIK3R5						V
NPPA						V
CACNA2D1							V
RYR1								V
+ 04926: Relaxin signaling pathway	0.4	1.9	0.6	2.5	0.3	1.3	0.5	0.3
MMP1	V		V			V		V
FOS	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PRKACB		V			V
EDNRB		V			V
TGFBR1		V
RELA			V
GNG2			V		V
RLN2			V		V
GNAI3			V		V
ACTA2			V
COL3A1			V
COL4A4			V		V
COL4A5			V		V
COL4A6			V
MMP13			V
RLN3			V		V
KRAS			V		V
PLCB1			V
SHC2			V		V		V
SHC4			V		V
RXFP1				V		V
NFKB1				V		V
MAPK1				V		V
PIK3R2				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
PRKACG				V		V
MMP2				V		V
MMP9				V		V
SMAD3				V		V
COL1A1				V
COL1A2				V
COL4A2				V		V
ADCY1				V		V
ADCY2				V		V		V
SRC				V		V
HRAS				V		V
MAP2K2				V		V
SHC1				V		V
MAP2K7				V		V
MAPK14				V
MAPK12				V		V
EGFR				V
GRB2				V		V
ARRB1				V		V
GNG10					V
SMAD2					V
SOS1					V
SOS2					V
GNB3						V
PRKACA						V
EDN1						V
PLCB2						V
MAPK11						V
MAPK13						V
VEGFA							V
+ 04918: Thyroid hormone synthesis	0.4	1.6	0	0.1	0.3	0.1	1.1	0.7
ATP1A3	V			V		V
PRKACB		V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
GPX8		V			V
PLCB1			V
SLC26A4			V		V
IYD			V		V
TTF2			V
ITPR2			V		V
ASGR2			V		V
PRKACG				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKCG				V		V
PDIA4				V		V
GSR				V		V
TG					V		V
HSP90B1					V
PRKACA						V
PLCB2						V
ATP1A4						V
DUOX2						V
ATP1B2							V
ALB							V
DUOXA2								V
+ 04919: Thyroid hormone signaling pathway	0.2	0.8	1.3	0.8	0.7	0.7	0.9	0.7
ATP1A3	V			V		V
ITGAV		V	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PRKACB		V			V
BMP4		V					V
PLCB1			V
PLCG1			V		V
PLCZ1			V					V
KRAS			V		V
THRB			V
HIF1A			V		V
RCAN2			V		V
TBC1D4			V		V
KAT2A			V		V
KAT2B			V		V
NCOA3			V		V
CREBBP			V		V
MED12L			V		V
MED4			V		V
MED13			V		V
NOTCH2			V		V
NOTCH3			V		V
MYC			V		V
PIK3R2				V		V
PRKCG				V		V
PLCG2				V		V		V
HRAS				V		V
MAP2K2				V		V
THRA				V		V
MTOR				V		V
PRKACG				V		V
MAPK1				V		V
TP53				V		V
DIO2				V		V
SLC16A2				V		V		V
RXRB				V		V
MED16				V		V
MED12				V		V
TSC2				V		V
BAD				V		V
SRC				V		V
NOTCH1				V		V
CTNNB1					V
ATP2A1					V
PLCB2						V
PRKACA						V
ATP1A4						V
DIO3						V
WNT4						V
GATA4							V
ATP2A3							V
ATP1B2							V
+ 04928: Parathyroid hormone synthesis, secretion and action	1.6	0.7	1.3	0.5	0.4	0.5	1.1	0.8
MMP15	V					V
CYP24A1	V		V					V
FOS	V		V
EGR1	V		V
PRKACB		V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
ITPR2			V		V
PLCB1			V
GNA11			V
GNAI3			V		V
PDE4C			V		V
PDE4D			V		V
GCM2			V
MMP17			V				V
GNA13			V		V
PLD1			V		V
JUND			V
LRP5			V		V
MMP13			V
MEF2C			V		V		V
NR4A2			V		V		V
MAFB			V		V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
VDR				V		V
ARRB1				V		V
ARAF				V		V
MAPK1				V		V
PRKCG				V		V
MMP25				V		V
EGFR				V
ARHGEF1				V		V
TRPV5				V		V
CDKN1A				V		V
KL				V		V		V
RXRB				V		V
GATA3					V
CYP27B1					V
MEF2A					V
PLCB2						V
PRKACA						V
PDE4A						V
ARHGEF11						V
TNFSF11						V
BGLAP						V
+ 04916: Melanogenesis	1.7	0.4	0.3	1	0.3	1.6	0.1	0.9
LEF1	V					V
TCF7	V					V
WNT10B	V					V
WNT5B	V					V
PRKACB		V			V
EDNRB		V			V
FZD7		V		V
CREB1		V			V
DVL3			V		V
CAMK2D			V		V
CALM1			V		V
CALML4			V
GNAI3			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
PLCB1			V
CREBBP			V		V
TCF7L2			V
TCF7L1			V		V
KRAS			V		V
DVL1				V		V
DVL2				V		V
DCT				V		V
TYRP1				V		V
PRKACG				V		V
CAMK2B				V
ADCY1				V		V
ADCY2				V		V		V
PRKCG				V		V
MC1R				V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
MAPK1				V		V
MAP2K2				V		V
HRAS				V		V
KITLG					V
CTNNB1					V
PRKACA						V
CALML3						V
PLCB2						V
WNT4						V
WNT3A						V
EDN1						V
+ 04924: Renin secretion	0.4	0.2	1.6	0	0.5	0.8	0.6	0.8
PDE1C	V		V
PRKACB		V			V
CREB1		V			V
ADRB1			V		V
NPR1			V				V
GNAI3			V		V
PLCB1			V
ITPR2			V		V
PRKG2			V		V
PDE3A			V		V
PTGER2			V		V
PTGER4			V
CALM1			V		V
CALML4			V
PPP3CA			V		V
PPP3CC			V
PRKACG				V		V
ADRB3				V		V		V
ORAI1				V		V
PDE1B				V		V
CACNA1F				V		V
ADCYAP1				V		V
EDNRA					V
PRKACA						V
PLCB2						V
AGT						V
CLCA1						V
CLCA2						V
CACNA1D						V
CALML3						V
NPPA						V
EDN1						V
ADORA1							V
PDE3B								V
+ 04614: Renin-angiotensin system	0	0	0.4	0	0.3	0.6	0	0
ATP6AP2			V		V
KLK2			V		V
PRCP			V		V
MME				V		V
NLN						V
ANPEP						V
AGT						V
KLK1						V
+ 04925: Aldosterone synthesis and secretion	0.7	1.8	0.2	1.1	0.2	1.1	0.8	0.5
PDE2A	V					V
ATP1A3	V			V		V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PRKACB		V			V
ATF1		V
ATP2B1		V			V
ATP2B4		V			V
ITPR2			V		V
PLCB1			V
GNA11			V
CALM1			V		V
CALML4			V
PRKCE			V		V
CAMK2D			V		V
NR4A2			V		V		V
NPR1			V				V
DAGLA			V
LDLR			V		V
KCNK3				V		V
KCNK9				V
CACNA1F				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKCG				V		V
PRKD2				V		V
CAMK4				V
CAMK2B				V
CAMK1				V		V
NR4A1				V		V
PRKACG				V		V
ORAI1				V		V
SCARB1				V		V
LIPE				V		V
CYP11A1				V		V		V
PRKD3					V
PLCB2						V
CACNA1D						V
CACNA1I						V
CALML3						V
PRKACA						V
ATP1A4						V
AGT						V
NPPA						V
ATP1B2							V
+ 04927: Cortisol synthesis and secretion	0	1.4	0	0.7	0	1	0	0.8
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PRKACB		V			V
ITPR2			V		V
PLCB1			V
GNA11			V
LDLR			V		V
CACNA1F				V		V
ADCY1				V		V
ADCY2				V		V		V
PDE8A				V
PRKACG				V		V
ORAI1				V		V
SCARB1				V		V
CYP11A1				V		V		V
KCNK3				V		V
NR4A1				V		V
PLCB2						V
CACNA1D						V
CACNA1I						V
PRKACA						V
NR0B1						V
AGT						V
+ 5.3 Circulatory system	1.3	1.3	0.8	0.7	0.4	1.2	1.6	0.7
+ 04260: Cardiac muscle contraction	0.8	0	0	0	0	0.2	0.9	0.2
COX7B2	V		V
ATP1A3	V			V		V
CACNA2D4			V		V
CACNG3				V		V		V
CACNA1F				V		V
TPM4				V		V
COX8A				V		V
CYC1				V		V
UQCRC1				V		V
HRC				V		V
CACNB4					V
ATP2A1					V
ASPH					V
CACNG2						V
CACNA2D3						V
CACNA1D						V
MYL4						V
COX6A2						V
ATP1A4						V
CACNA2D1							V
ATP2A3							V
ATP1B2							V
+ 04261: Adrenergic signaling in cardiomyocytes	0.7	1.2	0.1	0	0.2	0.1	1	0.5
ATP1A3	V			V		V
PIK3CG	V		V
PPP2R2C	V		V
PRKACB		V			V
AKT3		V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PPP1CB		V			V
ATP2B1		V			V
ATP2B4		V			V
CACNA2D4			V		V
ADRB1			V		V
GNAI3			V		V
SCN5A			V		V		V
PPP1CC			V		V
PPP2CB			V		V
PPP2R3A			V		V
CALM1			V		V
CALML4			V
CAMK2D			V		V
PLCB1			V
RAPGEF4			V		V		V
ADRA1A			V		V
CACNG3				V		V		V
CACNA1F				V		V
TPM4				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
PIK3R6				V		V
MAPK1				V		V
PPP1CA				V		V
CAMK2B				V
MAPK14				V
MAPK12				V		V
KCNE1				V
CACNB4					V
ATP2A1					V
PPP2R5C					V
CACNG2						V
CACNA2D3						V
CACNA1D						V
MYL4						V
ATP1A4						V
PRKACA						V
PIK3R5						V
PPP2R3B						V
CALML3						V
PLCB2						V
MAPK11						V
MAPK13						V
AGT						V
CACNA2D1							V
ATP2A3							V
ATP1B2							V
SCN7A								V
+ 04270: Vascular smooth muscle contraction	0.8	0.9	1.3	1.1	0.4	1.8	0.8	0.6
KCNU1	V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
PPP1R12A		V	V		V
PPP1CB		V			V
ROCK1		V	V		V
ROCK2		V			V
CALD1		V			V
ADORA2A		V		V
PRKACB		V			V
MYLK4			V		V
PPP1CC			V		V
PRKCE			V		V
PRKCH			V
ACTA2			V
ADRA1A			V		V
GNA11			V
GNA13			V		V
PLCB1			V
ITPR2			V		V
CALM1			V		V
CALML4			V
KCNMB3			V		V
KCNMB1			V		V
PLA2G5			V		V
NPR1			V				V
PRKG1			V		V
AVPR1A			V		V
MYLK2				V		V		V
MYL9				V
MYL6B				V		V
PPP1R12C				V		V
PPP1CA				V		V
PRKCG				V		V
ARHGEF1				V		V
ACTG2				V		V		V
CACNA1F				V		V
PPP1R14A				V		V
PLA2G4D				V		V
PLA2G2E				V		V
PLA2G2A				V		V
ARAF				V		V
MAP2K2				V		V
MAPK1				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
RAMP2				V		V
MYH11				V		V
AVP				V		V
NPPB				V		V	V
ARHGEF12					V
EDNRA					V
ARHGEF11						V
PLCB2						V
CALML3						V
CACNA1D						V
PLA2G4E						V
PLA2G4F						V
PRKACA						V
NPR2						V
AGT						V
NPPA						V
EDN1						V
CALCA						V
CALCRL							V
RAMP1							V
+ 5.4 Digestive system	3.1	1.1	1.9	2.1	1.1	3.2	2.9	2
+ 04970: Salivary secretion	0.3	0.3	0.4	0.4	0.1	0.6	0.4	1.5
ATP1A3	V			V		V
PRKACB		V			V
ATP2B1		V			V
ATP2B4		V			V
ADRB1			V		V
ADRA1A			V		V
SLC12A2			V		V
PLCB1			V
ITPR2			V		V
CALM1			V		V
CALML4			V
PRKG1			V		V
PRKG2			V		V
CD38			V
KCNN4			V		V		V
DMBT1			V
ADRB3				V		V		V
CHRM3				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
PRKCG				V		V
AQP5				V		V		V
MUC7				V		V
CST1				V		V		V
CST2				V		V
CST4				V		V
SLC4A2				V		V
PRKACA						V
PLCB2						V
CALML3						V
BST1						V
ATP1A4						V
ATP1B2							V
+ 04971: Gastric acid secretion	0.3	0	0.4	0.6	0.2	0.7	0.2	1.2
ATP1A3	V			V		V
PRKACB		V			V
PLCB1			V
ITPR2			V		V
HRH2			V		V
KCNK10			V		V
SLC26A7			V		V
GNAI3			V		V
CALM1			V		V
CALML4			V
MYLK4			V		V
CAMK2D			V		V
CCKBR				V		V
CHRM3				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
PRKCG				V		V
SLC9A4				V		V		V
SLC4A2				V		V
SST				V		V
MYLK2				V		V		V
CAMK2B				V
CFTR					V
PRKACA						V
PLCB2						V
ATP1A4						V
KCNJ1						V
CALML3						V
ATP1B2							V
+ 04972: Pancreatic secretion	0.7	0.1	0.1	0.1	0.4	0.5	1.2	0.1
ATP1A3	V			V		V
PRSS3	V					V
ATP2B1		V			V
ATP2B4		V			V
SLC12A2			V		V
PLCB1			V
ITPR2			V		V
CELA2A			V		V
PLA2G5			V		V
TRPC1			V		V
CD38			V
CTRL			V		V
RAB27B			V		V
RAC1			V		V
CHRM3				V		V
PRKCG				V		V
SLC4A2				V		V
TPCN2				V		V
CPA2				V		V
CPB1				V		V
PLA2G2E				V		V
PLA2G2A				V		V
ADCY1				V		V
ADCY2				V		V		V
CFTR					V
AMY2A					V
SLC4A4					V
ATP2A1					V
RAP1A					V
PLCB2						V
ATP1A4						V
CLCA1						V
CLCA2						V
PNLIP						V	V
BST1						V
CCK						V
ATP1B2							V
ATP2A3							V
SCT							V
+ 04976: Bile secretion	0.9	0	0.1	0.4	0.4	0.9	1.1	0.3
ATP1A3	V			V		V
KCNN2	V		V		V
PRKACB		V			V
SLCO1B3			V		V
SLCO1B7			V		V
ABCG8			V		V
ABCB4			V		V		V
LDLR			V		V
HMGCR			V		V
SLC4A2				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
ABCG5				V		V
SLC22A7				V		V
SLC10A2				V
NR0B2				V		V
SCARB1				V		V
CFTR					V
SLC4A4					V
ABCC4					V
ATP1A4						V
PRKACA						V
ABCC2						V
SLC22A1						V
BAAT						V
SLC9A3						V
SLC51A						V
ATP1B2							V
SCT							V
+ 04973: Carbohydrate digestion and absorption	1.4	1	0	0.2	0	0.8	0.4	0.5
ATP1A3	V			V		V
G6PC3	V					V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
SLC37A4				V		V
G6PC2				V		V
PIK3R2				V		V
TAS1R3				V		V
AMY2A					V
ATP1A4						V
MGAM						V		V
CACNA1D						V
PLCB2						V
ATP1B2							V
+ 04974: Protein digestion and absorption	1.8	0.3	1.7	1.4	0.3	0.6	1.3	0.2
SLC1A1	V		V
PRSS3	V					V
ATP1A3	V			V		V
COL6A5	V		V
SLC38A2		V	V		V
COL5A1		V
COL18A1		V		V		V
SLC7A9			V		V
SLC3A1			V		V
CTRL			V		V
CELA2A			V		V
KCNN4			V		V		V
KCNK5			V		V		V
DPP4			V		V
MEP1A			V
PRCP			V		V
COL3A1			V
COL4A4			V		V
COL4A5			V		V
COL4A6			V
COL5A2			V		V
COL21A1			V		V		V
SLC7A7				V
SLC15A1				V		V
SLC1A5				V		V
SLC3A2				V		V
CPA2				V		V
CPB1				V		V
MME				V		V
XPNPEP2				V		V
ELN				V		V
COL1A1				V
COL1A2				V
COL2A1				V		V
COL4A2				V		V
COL6A2				V		V
COL17A1				V		V		V
COL27A1				V		V
ATP1A4						V
SLC9A3						V
ATP1B2							V
+ 04975: Fat digestion and absorption	0	0.2	0.1	2.1	0	2.7	0.5	0
ABCA1		V		V
ABCG8			V		V
CD36			V
PLA2G5			V		V
ABCG5				V		V
APOB				V		V
PLA2G2E				V		V
PLA2G2A				V		V
AGPAT1				V		V
AGPAT2				V		V
MOGAT3				V		V
DGAT1				V		V
SLC27A4				V		V
SCARB1				V		V
FABP2					V
PNLIP						V	V
DGAT2						V
APOA1						V
PLPP2						V
GOT2						V
+ 04979: Cholesterol metabolism	1.3	0.1	0.6	0.7	0.3	0.6	0.9	0
ANGPTL4	V					V
LIPG	V		V		V
ABCA1		V		V
APOE			V		V
LDLR			V		V
CD36			V
PCSK9			V		V		V
VDAC2			V		V
ABCG8			V		V
APOB				V		V
SOAT1				V
LCAT				V		V
PLTP				V		V
SCARB1				V		V
TSPO				V		V
ABCG5				V		V
VAPA					V
APOA1						V
APOC3						V
LRPAP1						V
LRP1							V
+ 04977: Vitamin digestion and absorption	2.7	0	0.8	0.7	0.6	2.6	1.6	2.5
LRAT	V		V		V
SLC19A3	V		V					V
SLC52A3	V					V		V
SLC19A2			V		V
BTD			V		V
APOB				V		V
SCARB1				V		V
SLC5A6				V		V		V
PLB1				V		V
LMBRD1					V
APOA1						V
CUBN						V
TCN2						V
MMACHC						V
PNLIP						V	V
AWAT2							V
+ 04978: Mineral absorption	0.5	1.3	1.8	0.1	1.1	0.2	1.4	0
ATP1A3	V			V		V
ATP2B1		V			V
CYBRD1		V	V		V		V
ATP7A		V	V		V
TRPM7		V	V		V
S100G			V
SLC11A2			V		V
SLC40A1			V		V
FTH1			V		V
MT1H			V		V
MT1X			V				V
MT2A			V		V
STEAP1			V		V
CLCN2			V		V
VDR				V		V
FTL				V		V
HMOX2				V		V
MT1M				V		V
SLC39A4						V
SLC9A3						V
ATP1A4						V
ATP1B2							V
+ 5.5 Excretory system	1.4	1.4	1	1.4	1.2	2.1	1.4	0.2
+ 04962: Vasopressin-regulated water reabsorption	0	1.5	1.3	0.2	1.9	0.2	0	0
PRKACB		V			V
CREB1		V			V
CREB5		V			V
DYNC1I2		V
AQP3			V		V
ARHGDIG			V		V
RAB5A			V		V
RAB5B			V		V
DCTN2			V		V
DCTN4			V		V
DYNC1I1			V		V
DYNC1LI2			V		V
DYNC2LI1			V		V
AVP				V		V
PRKACG				V		V
RAB11B				V		V
RAB5C				V		V
NSF				V		V
PRKACA						V
DYNLL2						V
+ 04960: Aldosterone-regulated sodium reabsorption	1.5	0.7	0.5	1.6	0.3	1.6	0.5	0
ATP1A3	V			V		V
NR3C2	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
KRAS			V		V
IRS1			V		V
FXYD4				V		V
INSR				V		V
PIK3R2				V		V
INS				V		V
IGF1				V		V
SFN				V		V
MAPK1				V		V
PRKCG				V		V
NEDD4L					V
ATP1A4						V
KCNJ1						V
ATP1B2							V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	0.6	0.4	0.1	0.6	0.2	1.3	0.4	0.4
ATP1A3	V			V		V
ATP2B1		V			V
PRKACB		V			V
CALB1			V		V
AP2A1			V		V
PLCB1			V
KLK2			V		V
TRPV5				V		V
VDR				V		V
AP2M1				V		V
AP2S1				V		V
KL				V		V		V
PRKCG				V		V
PRKACG				V		V
DNM3					V
DNM2						V
PLCB2						V
KLK1						V
PRKACA						V
ATP1A4						V
ATP1B2							V
+ 04964: Proximal tubule bicarbonate reclamation	1	0.5	0	0.3	0.3	0.6	0.8	0
ATP1A3	V			V		V
GLS		V			V
MDH1			V		V
SLC38A3				V		V
SLC25A10				V		V
SLC4A4					V
SLC9A3						V
ATP1A4						V
ATP1B2							V
+ 04966: Collecting duct acid secretion	0	0	0.3	0.5	0.2	1	1.4	0
ATP6V1G3			V		V		V
ATP6V0D2			V		V		V
ATP6V1B1			V
TCIRG1				V		V
ATP6V1A				V		V
ATP6V0C				V		V
ATP6V0D1				V		V
ATP6V1C1					V
ATP6V0A1						V
ATP6V1F						V
SLC4A1						V
+ 5.6 Nervous system	3	1.7	1.3	4.1	0.8	3.8	1.5	0.7
+ 04724: Glutamatergic synapse	2	0.2	0.5	1.5	0.3	1.5	0.3	0.4
GRM5	V		V		V
SLC1A1	V		V
PLA2G4A	V		V		V
PLA2G4C	V		V
HOMER2	V					V
SLC38A2		V	V		V
PRKACB		V			V
GLS		V			V
GRIK2			V		V		V
PLCB1			V
ITPR2			V		V
TRPC1			V		V
GNAI3			V		V
GNG2			V		V
PPP3CA			V		V
PPP3CC			V
PLD1			V		V
HOMER3			V		V
HOMER1			V		V
GRIK3				V		V
GRIK5				V		V
GRIN2D				V
GRM1				V		V
GRM2				V		V		V
SLC1A6				V		V
ADCY1				V		V
ADCY2				V		V		V
SLC38A3				V		V
SLC17A8				V		V
PRKACG				V		V
PRKCG				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
GRK2				V		V
PLA2G4D				V		V
MAPK1				V		V
DLGAP1				V		V
GRIK4					V
SLC38A1					V
GNG10					V
GRIN2A						V
CACNA1D						V
PRKACA						V
PLCB2						V
GNB3						V
PLA2G4E						V
PLA2G4F						V
+ 04727: GABAergic synapse	0	0.6	0.1	1.9	0.3	1.7	1.8	0.5
GLS		V			V
PRKACB		V			V
TRAK2		V			V
SLC38A2		V	V		V
SLC32A1			V		V
GNAI3			V		V
GNG2			V		V
GABRB1			V		V		V
GABARAPL2			V
GABARAPL1			V		V		V
SLC12A5			V		V		V
GABBR2				V		V
ADCY1				V		V
ADCY2				V		V		V
GAD1				V		V
GAD2				V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
GABRA2				V		V
GABRE				V		V		V
PRKACG				V		V
NSF				V		V
CACNA1F				V		V
PRKCG				V		V
SRC				V		V
SLC38A3				V		V
GNG10					V
ABAT					V		V
SLC38A1					V
GNB3						V
GABRA4						V
GABRA6						V
GABRG2						V
PRKACA						V
CACNA1D						V
GABRR2						V
+ 04725: Cholinergic synapse	1	0.9	0.1	2	0	0.8	0.3	0.1
KCNQ3	V
PIK3CG	V		V
FOS	V		V
PRKACB		V			V
CREB1		V			V
CREB5		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
GNA11			V
PLCB1			V
ITPR2			V		V
GNAI3			V		V
GNG2			V		V
CAMK2D			V		V
KRAS			V		V
CHRM1				V		V
CHRM2				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
PRKCG				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
CHRM3				V		V
KCNQ5				V
KCNQ4				V		V
MAPK1				V		V
CAMK4				V
CAMK2B				V
PIK3R2				V		V
CACNA1F				V		V
PIK3R6				V		V
HRAS				V		V
JAK2				V		V
FYN				V
GNG10					V
PRKACA						V
PLCB2						V
GNB3						V
CACNA1D						V
PIK3R5						V
CHRM4							V
+ 04728: Dopaminergic synapse	0.4	1.5	0.2	0.2	0.2	0.1	0.2	0
FOS	V		V
PPP2R2C	V		V
PRKACB		V			V
AKT3		V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PPP1CB		V			V
KIF5B		V			V
CLOCK		V			V
PLCB1			V
ITPR2			V		V
MAOA			V
GNAI3			V		V
GNG2			V		V
PPP3CA			V		V
PPP3CC			V
CAMK2D			V		V
PPP2CB			V		V
PPP2R3A			V		V
PPP1CC			V		V
CALM1			V		V
CALML4			V
CALY			V		V		V
PRKACG				V		V
PRKCG				V		V
MAOB				V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
PPP1R1B				V		V
MAPK14				V
MAPK12				V		V
CAMK2B				V
PPP1CA				V		V
KCNJ9				V		V
GNG10					V
PPP2R5C					V
PRKACA						V
PLCB2						V
GNB3						V
MAPK11						V
MAPK13						V
DRD3						V
PPP2R3B						V
CALML3						V
CACNA1D						V
GRIN2A						V
+ 04726: Serotonergic synapse	2.4	0.3	0.2	1.3	0	1.2	0.6	0.1
PLA2G4A	V		V		V
PLA2G4C	V		V
CYP2J2	V					V
PTGS2	V		V		V
DUSP1	V					V
KCNN2	V		V		V
PRKACB		V			V
CYP2C9		V		V		V		V
ALOX5		V		V
PTGS1		V		V
PLCB1			V
ITPR2			V		V
GNAI3			V		V
GNG2			V		V
MAOA			V
TRPC1			V		V
KRAS			V		V
APP			V		V
GABRB1			V		V		V
PRKACG				V		V
PRKCG				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
MAOB				V
PLA2G4D				V		V
CACNA1F				V		V
HTR3C				V		V
ALOX12				V		V
CASP3				V
MAPK1				V		V
KCNJ9				V		V
HRAS				V		V
ARAF				V		V
GNG10					V
PRKACA						V
PLCB2						V
SLC6A4						V
GNB3						V
PLA2G4E						V
PLA2G4F						V
CACNA1D						V
CYP2C18						V
ALOX15						V
HTR1E							V
+ 04720: Long-term potentiation	0.4	0.6	1.1	1.1	0.7	0.9	0	0
GRM5	V		V		V
RPS6KA3		V	V		V
PRKACB		V			V
PPP1CB		V			V
CREBBP			V		V
CAMK2D			V		V
PPP3CA			V		V
PPP3CC			V
CALM1			V		V
CALML4			V
PPP1CC			V		V
KRAS			V		V
PLCB1			V
ITPR2			V		V
PRKCG				V		V
CAMK4				V
CAMK2B				V
RPS6KA2				V		V
GRIN2D				V
PRKACG				V		V
PPP1CA				V		V
ADCY1				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
GRM1				V		V
RAP1A					V
CALML3						V
RPS6KA1						V
GRIN2A						V
PRKACA						V
PLCB2						V
+ 04730: Long-term depression	1.1	0	1.1	0.7	0.2	0.9	0	0.3
PLA2G4A	V		V		V
PLA2G4C	V		V
PLCB1			V
GNA11			V
GNA13			V		V
GNAI3			V		V
PRKG1			V		V
PRKG2			V		V
KRAS			V		V
PPP2CB			V		V
ITPR2			V		V
PLA2G4D				V		V
GRM1				V		V
PRKCG				V		V
IGF1				V		V
PPP1R17				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
LYN				V		V
PLCB2						V
PLA2G4E						V
PLA2G4F						V
GRID2						V
RYR1								V
+ 04723: Retrograde endocannabinoid signaling	0.7	0	0	1.7	0	2.5	0.1	0.2
PTGS2	V		V		V
GRM5	V		V		V
NDUFA1	V
PRKACB		V			V
PLCB1			V
ITPR2			V		V
GABRB1			V		V		V
GNAI3			V		V
GNG2			V		V
DAGLA			V
SLC32A1			V		V
NAPEPLD			V		V
RIMS1			V		V
NDUFA5			V		V
NDUFC2			V
NDUFS4			V		V
SLC17A8				V		V
PRKCG				V		V
CACNA1F				V		V
GABRA2				V		V
GABRE				V		V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
GRM1				V		V
KCNJ9				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
FAAH				V		V
MAPK14				V
MAPK1				V		V
MAPK12				V		V
NDUFA7				V		V
NDUFAB1				V		V
NDUFB7				V		V
NDUFB10				V		V
NDUFS3				V		V
NDUFV1				V		V
NDUFS6				V		V
NDUFS8				V		V
NDUFA13				V		V
GNG10					V
NDUFB5					V
PLCB2						V
CACNA1D						V
GABRA4						V
GABRA6						V
GABRG2						V
GABRR2						V
GNB3						V
ABHD6						V
PRKACA						V
MAPK11						V
MAPK13						V
NDUFS7						V
NDUFC1						V
NDUFS2						V
NDUFB11						V
+ 04721: Synaptic vesicle cycle	1.4	0	0.2	1.2	0.2	1.6	1	0
CPLX1	V					V
SNAP25	V		V		V
SLC1A1	V		V
RAB3A		V			V
RIMS1			V		V
SYT1			V		V		V
AP2A1			V		V
SLC32A1			V		V
ATP6V1G3			V		V		V
ATP6V0D2			V		V		V
ATP6V1B1			V
STX1A				V		V
STX3				V		V
NAPA				V		V
NSF				V		V
AP2M1				V		V
AP2S1				V		V
UNC13C				V		V
SLC17A8				V		V
TCIRG1				V		V
ATP6V1A				V		V
ATP6V0C				V		V
ATP6V0B				V		V
ATP6V0D1				V		V
SLC1A6				V		V
SLC6A9				V		V
DNM3					V
ATP6V1C1					V
DNM2						V
UNC13B						V
ATP6V0A1						V
ATP6V1F						V
SLC6A4						V
+ 04722: Neurotrophin signaling pathway	0	1.4	0.4	1.5	0.7	0.9	0.6	0.7
NTF3		V		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
NGF		V		V
NGFR		V			V		V
AKT3		V
RPS6KA3		V	V		V
MAGED1		V		V		V		V
PLCG1			V		V
SHC2			V		V		V
SHC4			V		V
KRAS			V		V
RELA			V
CAMK2D			V		V
MAP3K5			V		V
IRS1			V		V
ARHGDIG			V		V
SH2B2			V
RAC1			V		V
CALM1			V		V
CALML4			V
NTF4				V		V
PIK3R2				V		V
PLCG2				V		V		V
SHC1				V		V
GRB2				V		V
HRAS				V		V
MAP2K2				V		V
MAPK1				V		V
RPS6KA2				V		V
BAD				V		V
NFKBIE				V		V		V
NFKB1				V		V
CAMK4				V
CAMK2B				V
TP53				V		V
MAPK14				V
MAPK12				V		V
SH2B1				V		V
MAP2K7				V		V
IRAK1				V		V
BAX				V		V
BDNF					V
SOS1					V
SOS2					V
RAP1A					V
GAB1					V
KIDINS220					V
MAPKAPK2					V
RPS6KA1						V
NFKBIB						V
FASLG						V
MAPK11						V
MAPK13						V
PRDM4						V
CALML3						V
+ 5.7 Sensory system	1.4	0.4	1.5	1.3	0.5	2.2	1	1.5
+ 04744: Phototransduction	0	0	1.3	0.1	0.7	0.4	0.7	0
CNGA1			V		V
SLC24A1			V		V
GRK1			V		V		V
SAG			V		V
CALM1			V		V
CALML4			V
GNB1				V		V
GNGT1				V		V
PDE6B						V
GNAT1						V
CALML3						V
+ 04740: Olfactory transduction	0.3	0	0	0.7	0	0.7	0.2	1.4
OR4S2	V			V		V
OR4S1	V					V		V
OR9K2	V		V		V		V
PDE1C	V		V
PDE2A	V					V
RGS2	V		V
OR4C11		V			V
PRKACB		V			V
OR5P2			V		V
OR2T12			V		V
OR6K6			V		V		V
OR9A2			V
OR2AG1			V
OR7A17			V		V
OR2T1			V		V
OR2J2			V		V
OR1L3			V		V		V
OR2T8			V		V
OR52A5			V		V
OR56A3			V		V
OR6C76			V		V		V
OR5AU1			V
OR2T33			V		V
OR51A4			V		V
OR51A2			V		V
OR10C1			V		V
OR4K5			V		V
OR1G1			V		V
ANO2			V		V
PRKG1			V		V
PRKG2			V		V
CAMK2D			V		V
CALM1			V		V
CALML4			V
GNB1				V		V
GNG13				V		V
OR5I1				V
OR51L1				V		V
OR51A7				V		V
OR4X2				V		V
OR5P3				V		V
OR10AD1				V		V
OR11H6				V
OR1I1				V		V
OR2T34				V		V
OR2B11				V
OR10X1				V		V		V
OR6N1				V		V
OR2Y1				V		V
OR2A14				V		V
OR13C8				V		V
OR13C4				V		V
OR1S2				V		V		V
OR1S1				V		V		V
OR5A2				V		V
OR6C3				V		V
OR52B2				V		V
OR4C3				V		V
OR2B6				V		V
OR2K2				V
OR5L2				V		V
OR5K1				V		V
OR10J1				V		V
OR10AG1				V		V
OR8D1				V		V
OR9G4				V		V
OR10A4				V
OR6C6				V		V
OR2L13				V		V
OR14A16				V
OR5AP2				V		V
OR8S1				V		V
OR2T3				V		V
OR6V1				V		V
OR51Q1				V		V
OR4X1				V		V
OR5T3				V		V		V
OR8A1				V		V	V
OR11G2				V		V
OR11H4				V		V
OR4F6				V				V
OR7G3				V		V
OR10K2				V		V
OR10K1				V		V
OR11L1				V		V
OR51T1				V		V		V
OR5K2				V		V
OR5K4				V		V
OR11H12				V		V
OR10J3				V		V
OR3A2				V		V
OR11H2				V		V
OR5AC2				V		V
OR11H1				V		V
OR4P4				V		V		V
OR2C3				V		V
CAMK2B				V
PDE1B				V		V
PRKACG				V		V
ARRB1				V		V
GRK2				V		V
OR5J2					V
OR51V1					V
OR6S1					V
OR8I2						V
OR10H4						V
OR2T11						V
OR6P1						V
OR13C3						V
OR5M3						V
OR8B12						V
OR9Q2						V
OR51F1						V
OR1J4						V
OR10H3						V
OR10G3						V
OR10R2						V
OR56B1						V
OR5D16						V
OR5AN1						V
OR4K13						V
OR2T27						V
OR13A1						V
OR51B2						V
OR6N2						V
OR1A1						V
OR3A3						V
CALML3						V
PRKACA						V
OR5R1							V
OR6F1							V
OR4C15							V
OR2T4								V
OR52A1								V
OR52L1								V
OR52N5								V
OR51E2								V
+ 04742: Taste transduction	0.3	0.1	0	0.8	0	1.6	0.5	0.6
PDE1C	V		V
SCN3A		V			V
PRKACB		V			V
SCN9A			V		V
TAS2R20			V		V
TAS2R50			V		V
TAS2R38			V		V
KCNK5			V		V		V
PDE1B				V		V
TAS2R39				V		V
TAS2R41				V		V		V
TAS2R16				V		V		V
TAS1R1				V		V
GRM1				V		V
TAS1R3				V		V
GABRA2				V		V
GABBR2				V		V
P2RX3				V		V
CHRM3				V		V
HTR3C				V		V
PRKACG				V		V
GNG13				V		V
PLCB2						V
CALHM1						V
TAS2R1						V
ASIC2						V
GABRA4						V
GABRA6						V
PRKACA						V
GNB3						V
HTR1E							V
+ 04750: Inflammatory mediator regulation of TRP channels	2.2	0.8	1.7	1	0.3	1.6	0.7	0.9
BDKRB1	V					V
PLA2G4A	V		V		V
PLA2G4C	V		V
CYP2J2	V					V
TRPV2	V		V
NGF		V		V
PRKACB		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
PPP1CB		V			V
PTGER2			V		V
PTGER4			V
IL1RAP			V		V
PLCB1			V
PRKCE			V		V
CAMK2D			V		V
PLCG1			V		V
ITPR2			V		V
TRPV4			V		V		V
PPP1CC			V		V
F2RL1			V
PRKCH			V
CALM1			V		V
CALML4			V
MAP2K6			V		V		V
P2RY2				V		V
IL1B				V		V		V
PLA2G4D				V		V
ALOX12				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
CAMK2B				V
MAPK14				V
MAPK12				V		V
PLCG2				V		V		V
PIK3R2				V		V
SRC				V		V
PPP1CA				V		V
IGF1				V		V
PRKCG				V		V
MAP2K3				V		V
ASIC2						V
ASIC4						V
PLA2G4E						V
PLA2G4F						V
PLCB2						V
PRKACA						V
MAPK11						V
MAPK13						V
CALML3						V
ASIC5							V
+ 5.8 Development and regeneration	1.6	1.3	1.7	2.2	1.5	2.2	0.2	0.8
+ 04360: Axon guidance	0.9	1.1	2.2	0.9	2.1	1.3	0	0.6
PARD6A	V
SEMA3A	V		V		V
SEMA3F	V					V
WNT5B	V					V
ROCK1		V	V		V
ROCK2		V			V
BUB1B-PAK6		V		V
PAK6		V		V
RASA1		V			V
MET		V			V
SEMA3C		V	V		V
BMPR2		V	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
GNAI3			V		V
RAC1			V		V
RAC3			V		V
PPP3CA			V		V
PPP3CC			V
NTNG1			V
NTN4			V		V
NCK1			V		V
ROBO1			V		V
EPHA4			V		V
EPHA5			V		V
EFNB3			V		V
EFNA3			V
PLXNA2			V
SEMA3D			V		V
SEMA3E			V		V
SEMA6D			V		V
KRAS			V		V
FZD3			V		V
CAMK2D			V		V
TRPC1			V		V
TRPC3			V		V
TRPC5			V		V
TRPC6			V		V
DPYSL2			V		V
PLCG1			V		V
ABLIM3			V		V
NEO1			V
MYL12A			V		V
MYL5			V
CXCR4				V		V
MAPK1				V		V
RAC2				V		V
NFATC2				V		V
NFATC3				V		V
SLIT3				V		V
SLIT2				V		V
UNC5B				V		V
EPHB4				V		V
SEMA7A				V		V
FYN				V
PLXNA3				V		V
SEMA4D				V		V
SRGAP3				V		V
L1CAM				V		V
CXCL12				V
SRC				V		V
HRAS				V		V
SHH				V		V
LIMK1				V
CAMK2B				V
TRPC4				V		V		V
PIK3R2				V		V
RHOD				V		V
FES				V		V
CFL1				V		V		V
RRAS				V		V
PLCG2				V		V		V
MYL9				V
ITGB1					V
EFNB2					V
ARHGEF12					V
PLXNC1					V
NRP1					V
PDK1					V
CFL2					V
ENAH					V
DCC						V
PAK1						V
ROBO3						V
EPHA6						V
EFNB1						V
EPHB6						V
EFNA2						V
PLXNB2						V
PLXNA1						V
SEMA4F						V
SEMA4A						V
SEMA5B						V
PTCH1						V
GDF7						V
WNT4						V
CDK5						V
RND1							V
SEMA3G								V
+ 04380: Osteoclast differentiation	1.3	0.7	0.3	2.2	0	1.8	0.2	0.6
TNFRSF11A	V					V
FOS	V		V
FOSB	V
JUNB	V		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
CREB1		V			V
TNF		V		V		V		V
TGFBR1		V
GAB2			V
RELA			V
MAP2K6			V		V		V
JUND			V
FCGR2A			V		V
TEC			V		V
PPP3CA			V		V
PPP3CC			V
CTSK			V		V
RAC1			V		V
NOX1			V		V		V
OSCAR			V
TRAF2				V		V
CSF1				V		V
CYLD				V		V
NFKB1				V		V
MAPK14				V
MAPK12				V		V
TYK2				V		V
FYN				V
PIK3R2				V		V
IL1A				V		V
IL1B				V		V		V
FOSL1				V		V
PLCG2				V		V		V
CAMK4				V
ACP5				V		V
TNFRSF1A				V		V
NFATC2				V		V
SOCS1				V		V
NFKB2				V		V
RELB				V		V
SQSTM1				V		V
GRB2				V		V
MAPK1				V		V
MAP2K7				V		V
CYBA				V		V
NCF2				V		V
LILRB5				V		V
SIRPA				V		V
IFNGR1					V
TNFSF11						V
TAB1						V
MAPK11						V
MAPK13						V
FOSL2						V
LILRA4						V
+ 5.9 Aging	0.7	3.6	1.4	2.8	1.3	2.3	0.1	1.7
+ 04211: Longevity regulating pathway	0	3.1	0.6	2.8	0.7	2.2	0.1	1.5
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PRKACB		V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
ATG5		V	V		V
APPL1		V	V		V
RB1CC1		V	V		V
RPS6KB1			V		V
RPTOR			V
IRS1			V		V
IRS2			V		V
KRAS			V		V
PRKAA2			V		V
SESN3			V		V
RELA			V
RPS6KB2				V		V
MTOR				V		V
PIK3R2				V		V
IGF1				V		V
HRAS				V		V
PRKACG				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKAG3				V		V		V
PRKAG1				V		V
INS				V		V
INSR				V		V
TSC2				V		V
EIF4EBP1				V		V
EIF4E1B				V		V	V
TP53				V		V
ADIPOR1				V		V
BAX				V		V
KL				V		V		V
CAMKK2				V		V		V
CAMK4				V
NFKB1				V		V
ATG101				V		V
SIRT1					V
PRKACA						V
PRKAB1						V
STK11						V
ATG13						V
+ 04213: Longevity regulating pathway - multiple species	1.1	1.9	1.3	1.1	1.1	1.1	0	0.8
FOXA2	V		V		V
CLPB	V					V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PRKACB		V			V
CRYAB		V	V		V
ATG5		V	V		V
RPS6KB1			V		V
RPTOR			V
IRS1			V		V
IRS2			V		V
KRAS			V		V
PRKAA2			V		V
HSPA1L			V		V
RPS6KB2				V		V
MTOR				V		V
PIK3R2				V		V
IGF1				V		V
HRAS				V		V
INS				V		V
INSR				V		V
PRKACG				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKAG3				V		V		V
PRKAG1				V		V
SIRT1					V
PRKACA						V
PRKAB1						V
+ 5.10 Environmental adaptation	0.9	1	0.5	1.4	0.3	1.7	0.6	0.9
+ 04710: Circadian rhythm	0	1.5	0.8	0.2	0.5	0.3	0.6	0.7
CLOCK		V			V
FBXL3		V	V		V
CREB1		V			V
NPAS2			V		V
PRKAA2			V		V
BHLHE41			V
BHLHE40			V				V
CRY2				V		V
PRKAG3				V		V		V
PRKAG1				V		V
PER1						V
PRKAB1						V
+ 04713: Circadian entrainment	0.7	0.1	0.1	0.9	0	0.8	0.4	0.5
RASD1	V		V		V		V
FOS	V		V
PRKACB		V			V
CREB1		V			V
CALM1			V		V
CALML4			V
CAMK2D			V		V
PRKG1			V		V
PRKG2			V		V
PLCB1			V
GNG2			V		V
GNAI3			V		V
GRIN2D				V
CAMK2B				V
MTNR1B				V		V
PRKCG				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
MAPK1				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
KCNJ9				V		V
ADCYAP1				V		V
GNG10					V
GRIN2A						V
CALML3						V
PLCB2						V
GNB3						V
CACNA1I						V
PRKACA						V
CACNA1D						V
PER1						V
RYR1								V
+ 04714: Thermogenesis	0.9	0.1	0	1.3	0	1.9	0.1	0.3
DPF1	V					V
CPT1C	V		V
SLC25A29	V			V		V
COX7B2	V		V
NDUFA1	V
CREB1		V			V
CREB5		V			V
PRKACB		V			V
ATF2		V			V
RPS6KA3		V	V		V
ACSL3		V	V		V		V
ACSL4		V			V
NPR1			V				V
PRKG1			V		V
PRKG2			V		V
KDM3B			V		V
KDM3A			V		V
SMARCA2			V		V
PLIN1			V		V
RPTOR			V
RPS6KB1			V		V
KRAS			V		V
MAP3K5			V		V
PRKAA2			V		V
COX11			V
NDUFA5			V		V
NDUFC2			V
NDUFS4			V		V
COA5			V		V
COA1			V		V
SDHD			V		V
COX14			V		V
PRKACG				V		V
MAPK14				V
MAPK12				V		V
ADRB3				V		V		V
ADCY1				V		V
ADCY2				V		V		V
SIRT6				V		V
SMARCB1				V		V
ARID1A				V
LIPE				V		V
KDM1A				V		V
RPS6KA2				V		V
TSC2				V		V
MTOR				V		V
RPS6KB2				V		V
GRB2				V		V
HRAS				V		V
ACSL1				V		V
PNPLA2				V		V
MAP2K3				V		V
PRKAG3				V		V		V
PRKAG1				V		V
BMP8A				V		V
COX8A				V		V
CYC1				V		V
NDUFA7				V		V
NDUFAB1				V		V
NDUFB7				V		V
NDUFB10				V		V
NDUFS3				V		V
NDUFV1				V		V
NDUFS6				V		V
NDUFS8				V		V
NDUFA13				V		V
SDHB				V		V
COA7				V		V
UQCRC1				V		V
NDUFAF5				V		V
ATP5F1B				V		V
ATP5MC1				V		V		V
NPPB				V		V	V
ARID1B					V
SOS1					V
SOS2					V
NDUFB5					V
PRKACA						V
MAPK11						V
MAPK13						V
SMARCA4						V
RPS6KA1						V
MLST8						V
PRKAB1						V
SLC25A20						V
COX6A2						V
NDUFS7						V
NDUFC1						V
NDUFS2						V
COA4						V
NDUFB11						V
ATP5F1D						V
NPPA						V
+ 6. Human Diseases	5.8	6.9	4.4	11.8	4.4	8.7	2.6	3.4
+ 6.1 Cancer: overview	4.1	3.6	2.8	6.1	2.6	3.7	2.2	2.7
+ 05200: Pathways in cancer	2.5	0.5	0.7	3.2	0.6	2.8	0.7	1.1
WNT10B	V					V
WNT5B	V					V
APC2	V		V		V
FOS	V		V
LEF1	V					V
TCF7	V					V
RARB	V		V
CCND2	V		V
CCNA1	V		V		V		V
BMP2	V		V
HHIP	V		V
PTGS2	V		V		V
MMP1	V		V			V		V
BDKRB1	V					V
HEYL	V					V
GSTT2	V
GSTT2B	V
ITGAV		V	V		V
PTEN		V	V		V
FZD7		V		V
APPL1		V	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
MET		V			V
ARNT2		V		V
TGFBR1		V
RB1		V			V
CCNE2		V			V			V
BMP4		V					V
BIRC3		V			V			V
XIAP		V			V
AKT3		V
GLI2		V			V
EDNRB		V			V
PRKACB		V			V
ROCK1		V	V		V
ROCK2		V			V
NFE2L2		V			V
POLK		V	V		V
CTNNA1			V		V
DVL3			V		V
COL4A4			V		V
COL4A5			V		V
COL4A6			V
FN1			V		V		V
LAMA5			V		V		V
ITGA2			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
FGFR3			V
TPR			V		V
TGFA			V		V
APC			V		V
CDKN1B			V
KRAS			V		V
RELA			V
CCDC6			V
PLCG1			V		V
RAC1			V		V
RAC3			V		V
PLD1			V		V
MYC			V		V
TCF7L2			V
TCF7L1			V		V
HIF1A			V		V
CREBBP			V		V
BRCA2			V		V
TGFB3			V		V
CTBP1			V
CEBPA			V		V
FAS			V		V
FADD			V		V
PGF			V		V		V
FGF20			V		V
FGF17			V		V
F2R			V		V
PTGER2			V		V
PTGER4			V
GNG2			V		V
GNA13			V		V
PLEKHG5			V		V
GNA11			V
PLCB1			V
GNAI3			V		V
NOTCH2			V		V
NOTCH3			V		V
HEY1			V		V
GSTO2			V
ESR2			V		V
NCOA3			V		V
LRP5			V		V
RPS6KB1			V		V
CALM1			V		V
CALML4			V
CAMK2D			V		V
BBC3			V		V		V
APAF1			V		V
IL7			V		V
IL12B			V		V
IL4R			V		V
CASP3				V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
DVL1				V		V
DVL2				V		V
LAMC3				V		V
COL4A2				V		V
LAMA4				V
LAMB3				V		V
LAMC2				V		V
BCR				V		V
PIK3R2				V		V
STAT5B				V		V
JAK2				V		V
EGFR				V
FLT3				V
FGFR4				V		V	V
PDGFA				V		V
IGF1				V		V
AXIN1				V		V
MTOR				V		V
BAD				V		V
BCL2L1				V		V
STAT3				V
GRB2				V		V
HRAS				V		V
ARAF				V		V
MAP2K2				V		V
RASSF1				V		V
NFKB1				V		V
NFKB2				V		V
RET				V		V
PLCG2				V		V		V
RAC2				V		V
TP53				V		V
PRKCG				V		V
SHH				V		V
SUFU				V		V
FH				V		V
EGLN2				V		V
SMAD3				V		V
BAX				V		V
GSTP1				V		V
RXRB				V		V
ZBTB16				V		V
ZBTB17				V		V
CCND3				V
CDKN1A				V		V
CDK4				V		V
E2F1				V		V
CDK2				V		V
CCNE1				V		V
PTCH2				V		V
BIRC5				V		V
TRAF1				V		V
TRAF2				V		V
TRAF3				V		V
TRAF4				V		V
DAPK2				V		V
MMP2				V		V
MMP9				V		V
CXCL8				V		V		V
IL6				V		V
PPARD				V		V
NKX3-1				V		V
MAPK1				V		V
FLT3LG				V		V
LPAR4				V		V
LPAR2				V		V
ADCY1				V		V
ADCY2				V		V		V
PRKACG				V		V
GNB1				V		V
GNB2				V		V
GNG4				V
GNGT1				V		V
GNGT2				V
GNG13				V		V
GNG8				V		V	V
ARHGEF1				V		V
RASGRP4				V		V
CXCR4				V		V
CXCL12				V
NOTCH1				V		V
DLL4				V		V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
TXNRD1				V
GADD45A				V		V
TERT				V		V
RPS6KB2				V		V
CAMK2B				V
ELK1				V		V
PIM2				V		V
IL23A				V		V
CSF2RB				V		V
IL2RG				V		V
IL15RA				V		V
STAT4				V		V
STAT6				V		V
CTNNB1					V
ITGB1					V
HSP90AA1					V
HSP90B1					V
SOS1					V
SOS2					V
EGLN3					V
EGLN1					V
MSH2					V
SMAD2					V
MECOM					V
KITLG					V
LPAR5					V		V
EDNRA					V
GNG10					V
ARHGEF12					V
EML4					V
PMAIP1					V
IFNGR1					V
IL6ST					V
DCC						V
WNT4						V
WNT3A						V
LAMB4						V
JAK3						V
FGFR2						V
EGF						V
PTCH1						V
FASLG						V
FGF6						V
FGF8						V
FGF22						V
PRKACA						V
GNB3						V
ARHGEF11						V
PLCB2						V
DLL3						V
DLL1						V
GSTT1						V
CALML3						V
BCL2L11						V
IFNA6						V
IFNA14						V
IFNA21						V
IL13						V
IL2RB						V
IL6R						V		V
IL7R						V		V
EDN1						V
AGT						V
PDGFB							V
JUP							V
VEGFA							V
F2RL3							V
RAD51								V
SKP2								V
+ 05202: Transcriptional misregulation in cancer	1.2	1	0.4	2.1	0.4	0.8	2.3	1.2
IGFBP3	V
MMP3	V					V		V
CCNA1	V		V		V		V
BCL2A1	V					V		V
CCND2	V		V
ATF1		V
WT1		V		V		V		V
ARNT2		V		V
MET		V			V
ZEB1		V	V		V
BIRC3		V			V			V
JMJD1C		V	V		V
NGFR		V			V		V
CCNT2		V			V
POLK		V	V		V
ETV1			V		V		V
SS18			V		V
MYC			V		V
ATM			V		V
BAIAP3			V				V
DDX5			V		V
SPINT1			V		V
CEBPA			V		V
KMT2A			V		V
PBX3			V		V
SMAD1			V
MEF2C			V		V		V
CDKN1B			V
CDK14			V		V
DOT1L			V		V
MEIS1			V
SIX4			V		V
BCL6			V		V		V
TAF15			V		V
RELA			V
ETV4				V		V
DDIT3				V		V
PAX3				V		V
ASPSCR1				V		V
TFE3				V		V
PDGFA				V		V
FLT1				V		V
NUPR1				V		V
CDKN1A				V		V
IGF1				V		V
IL6				V		V
CXCL8				V		V		V
TMPRSS2				V
SLC45A3				V		V
MMP9				V		V
RXRB				V		V
ZBTB16				V		V
CEBPE				V		V
CD14				V		V
TRAF1				V		V
BCL2L1				V		V
CD40				V		V
ETV7				V
FLT3				V
ZBTB17				V		V
TP53				V		V
MEN1				V		V
CDK9				V		V
CDKN2C				V		V
HPGD				V		V
TLX3				V		V	V
PLAT				V		V
NFKB1				V		V
LDB1				V		V
LYL1				V		V
GADD45A				V		V
BAX				V		V
MLF1					V
REL					V
KDM6A					V
PROM1					V
MLLT3					V
DUSP6					V		V
IL2RB						V
UTY						V
PLAU							V
JUP							V
FLI1								V
+ 05206: MicroRNAs in cancer	2.4	1.8	3	2.4	2.7	1	1.7	1.6
CCND2	V		V
SERPINB5	V		V				V
CYP24A1	V		V					V
APC2	V		V		V
SOX4	V		V		V		V
TNC	V
PTGS2	V		V		V
PTEN		V	V		V
ZEB1		V	V		V
CYP1B1		V		V
MET		V			V
CCNE2		V			V			V
TIMP3		V		V		V		V
PIK3CA		V	V		V
ROCK1		V	V		V
BMPR2		V	V		V
GLS		V			V
DICER1		V			V
KRAS			V		V
CDKN1B			V
PDCD4			V		V
CREBBP			V		V
DDIT4			V		V		V
SPRY2			V		V
RPTOR			V
CCNG1			V		V
MYC			V		V
DNMT1			V		V
APC			V		V
IRS1			V		V
IRS2			V		V
NOTCH2			V		V
NOTCH3			V		V
RECK			V		V
PRKCE			V		V
ZFPM2			V		V
ATM			V		V
FZD3			V		V
EFNA3			V
FGFR3			V
PLCG1			V		V
SHC4			V		V
CDC25A				V		V		V
CDC25B				V		V
BCL2L2				V		V
DNMT3B				V		V
ST14				V		V
RASSF1				V		V
MMP9				V		V
CCNE1				V		V
EGFR				V
MTOR				V		V
STAT3				V
CASP3				V
HRAS				V		V
PIK3R2				V		V
NOTCH1				V		V
E2F1				V		V
CD44				V		V
SLC45A3				V		V
EZH2				V		V		V
CDCA5				V		V
KIF23				V		V
CDKN1A				V		V
SOCS1				V		V
NFKB1				V		V
MAPK1				V		V
PRKCG				V		V
GRB2				V		V
TP53				V		V
PLCG2				V		V		V
MAP2K2				V		V
SHC1				V		V
PDGFA				V		V
HNRNPK					V
SIRT1					V
MARCKS					V
MDM4					V
SOS1					V
SOS2					V
SLC7A1						V
BCL2L11						V
WNT3A						V
VEGFA							V
PLAU							V
PDGFB							V
BMF							V
+ 05205: Proteoglycans in cancer	0.4	2.7	1.2	2.5	1.7	2	1.2	0.8
ANK3	V		V		V
WNT10B	V					V
WNT5B	V					V
TIAM1		V
ROCK1		V	V		V
ROCK2		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
PPP1R12A		V	V		V
PPP1CB		V			V
MET		V			V
TIMP3		V		V		V		V
TNF		V		V		V		V
LUM		V
ITGAV		V	V		V
FZD7		V		V
PRKACB		V			V
CAV1		V			V
CAV2		V	V		V
ANK1			V		V		V
PPP1CC			V		V
ITPR2			V		V
CAMK2D			V		V
RAC1			V		V
IQGAP1			V		V
KRAS			V		V
DDX5			V		V
NUDT16L1			V
PDCD4			V		V
ERBB4			V
MYC			V		V
HIF1A			V		V
IL12B			V		V
RPS6KB1			V		V
FAS			V		V
COL21A1			V		V		V
ITGA2			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
SDC2			V		V
FN1			V		V		V
PLCG1			V		V
KDR			V
GPC1			V		V		V
CD44				V		V
PIK3R2				V		V
PPP1R12C				V		V
PPP1CA				V		V
CAMK2B				V
MAPK1				V		V
ELK1				V		V
HRAS				V		V
RRAS				V		V
ARAF				V		V
MAP2K2				V		V
DROSHA				V		V
STAT3				V
HCLS1				V		V
SRC				V		V
GRB2				V		V
ARHGEF1				V		V
TP53				V		V
MMP9				V		V
PLAUR				V		V
MMP2				V		V
CDKN1A				V		V
IGF1				V		V
MTOR				V		V
RPS6KB2				V		V
MSN				V		V
PLCG2				V		V		V
PRKCG				V		V
SHH				V		V
HSPG2				V		V
CTSL				V		V
PRKACG				V		V
MAPK14				V
MAPK12				V		V
TWIST2				V		V
EGFR				V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
CASP3				V
ARHGEF12					V
GAB1					V
SMAD2					V
CTNNB1					V
ITGB1					V
SOS1					V
SOS2					V
PAK1						V
VAV1						V
PXN						V
FASLG						V
GPC3						V
PTCH1						V
PRKACA						V
MAPK11						V
MAPK13						V
WNT4						V
WNT3A						V
PLAU							V
VEGFA							V
+ 05204: Chemical carcinogenesis	3.5	0.4	0	1	0	0.5	0	2.1
UGT2B28	V		V
UGT2B7	V		V
UGT2B10	V		V		V
ALDH1A3	V					V		V
GSTT2	V
GSTT2B	V
PTGS2	V		V		V
CYP1B1		V		V
CYP2C9		V		V		V		V
HSD11B1		V		V
CYP1A2			V		V
GSTO2			V
KYAT3			V		V
UGT2A3				V		V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
GSTK1				V
CYP2A6				V		V
CYP2E1						V
UGT2B11						V
GSTT1						V
CYP2C18						V
NAT2						V
AKR1C2								V
+ 05203: Viral carcinogenesis	0.4	1.6	0	1.8	0.2	0.4	0.6	0.2
EGR2	V		V
CCND2	V		V
CCNA1	V		V		V		V
DLG1		V			V
RB1		V			V
CREB1		V			V
ATF2		V			V
ATF6B		V		V
CREB5		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
CCNE2		V			V			V
HDAC9		V			V
RASA2		V			V
PRKACB		V			V
CDK1		V			V
UBE3A			V		V
RBL2			V		V
RELA			V
KAT2A			V		V
KAT2B			V		V
CCR4			V
KRAS			V		V
CREBBP			V		V
GTF2B			V		V
ATP6V0D2			V		V		V
CDKN1B			V
HDAC5			V		V		V
RAC1			V		V
SCIN			V		V
TP53				V		V
IRF3				V		V
RBL1				V
CASP3				V
BAX				V		V
BAD				V		V
TRAF1				V		V
TRAF2				V		V
TRAF3				V		V
SRC				V		V
MAPK1				V		V
STAT3				V
STAT5B				V		V
PIK3R2				V		V
NFKB1				V		V
NFKB2				V		V
CDK2				V		V
CDK4				V		V
MAD1L1				V		V
VAC14				V		V
RANBP1				V		V
SRF				V		V
LYN				V		V
CCND3				V
CCNE1				V		V
UBR4				V		V
HPN				V		V
HRAS				V		V
ATP6V0D1				V		V
CDKN1A				V		V
HDAC7				V		V
GSN				V			V
ACTN1				V		V
CDC20				V		V
C3				V		V		V
HLA-F				V
PRKACG				V		V
GRB2				V		V
H2BFWT				V		V
PMAIP1					V
REL					V
IL6ST					V
MAPKAPK2					V
HNRNPK					V
PXN						V
EGR3						V
JAK3						V
LTBR						V
PRKACA						V
TBPL2							V
SKP2								V
+ 05230: Central carbon metabolism in cancer	0	1.7	0.6	1.5	0.6	0.8	0	0
GLS		V			V
MET		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
PTEN		V	V		V
SLC16A3			V		V
MYC			V		V
HIF1A			V		V
SIRT3			V		V
FGFR3			V
KRAS			V		V
IDH1			V		V
SIRT6				V		V
PDHA1				V
PDHA2				V		V
EGFR				V
FLT3				V
RET				V		V
HRAS				V		V
MAP2K2				V		V
MAPK1				V		V
PIK3R2				V		V
MTOR				V		V
SLC1A5				V		V
TP53				V		V
PFKL				V		V
G6PD				V		V
PDK1					V
FGFR2						V
PGAM2						V
SCO2						V
+ 05231: Choline metabolism in cancer	1.7	0.5	1.5	1.7	1.2	1.5	0.1	0.9
PLA2G4A	V		V		V
PLA2G4C	V		V
WASF3	V							V
FOS	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
WASL		V			V
KRAS			V		V
PDGFC			V		V
PDGFD			V		V
SLC44A3			V		V
SLC44A1			V		V
CHKB			V
PLCG1			V		V
CHPT1			V		V
PLD1			V		V
RPS6KB1			V		V
DGKD			V		V
RAC1			V		V
RAC3			V		V
HIF1A			V		V
MAPK1				V		V
HRAS				V		V
MAP2K2				V		V
PIK3R2				V		V
EGFR				V
GRB2				V		V
PDGFA				V		V
SLC22A4				V		V
SLC44A4				V		V
CHKA				V		V
PLA2G4D				V		V
TSC2				V		V
MTOR				V		V
RPS6KB2				V		V
EIF4EBP1				V		V
DGKK				V		V		V
DGKA				V		V
PIP5K1C				V		V
RAC2				V		V
WASF2				V		V
PRKCG				V		V
SOS1					V
SOS2					V
LYPLA1					V
EGF						V
SLC22A1						V
PLA2G4E						V
PLA2G4F						V
PLPP2						V
PDGFB							V
PCYT1B								V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	0.3	0.6	1	2.3	0.4	1.5	0.1	0.2
FOS	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
PTEN		V	V		V
RELA			V
KRAS			V		V
PPP3CA			V		V
PPP3CC			V
PLCG1			V		V
CD247			V		V
CD28			V		V
MAP2K6			V		V		V
RPS6KB1			V		V
HIF1A			V		V
CD4			V		V
NFKBIE				V		V		V
NFKB1				V		V
PIK3R2				V		V
HRAS				V		V
NFATC2				V		V
NFATC3				V		V
MAP2K2				V		V
MAPK1				V		V
EGFR				V
JAK2				V		V
STAT3				V
TLR9				V		V
MAP2K3				V		V
MAPK14				V
MAPK12				V		V
CSNK2A1				V		V
CSNK2B				V		V
MYD88				V		V
MTOR				V		V
RPS6KB2				V		V
TICAM1				V		V
TIRAP				V		V
IFNGR1					V
EML4					V
NFKBIB						V
EGF						V
MAPK11						V
MAPK13						V
+ 6.2 Cancer: specific types	5.3	5.8	3.5	9.1	3.5	7.3	1.4	1.5
+ 05210: Colorectal cancer	2.4	1.3	1.8	1.8	2.2	1.5	0.1	0
APC2	V		V		V
FOS	V		V
LEF1	V					V
TCF7	V					V
EREG	V		V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
APPL1		V	V		V
TGFBR1		V
AKT3		V
POLK		V	V		V
TGFB3			V		V
APC			V		V
KRAS			V		V
RAC1			V		V
RAC3			V		V
MYC			V		V
TCF7L2			V
TCF7L1			V		V
BBC3			V		V		V
RPS6KB1			V		V
TGFA			V		V
CASP3				V
PIK3R2				V		V
SMAD3				V		V
ARAF				V		V
AXIN1				V		V
RAC2				V		V
BIRC5				V		V
MAP2K2				V		V
MAPK1				V		V
TP53				V		V
BAD				V		V
BAX				V		V
CDKN1A				V		V
GADD45A				V		V
HRAS				V		V
RPS6KB2				V		V
GRB2				V		V
MTOR				V		V
EGFR				V
SMAD2					V
MSH2					V
CTNNB1					V
PMAIP1					V
SOS1					V
SOS2					V
DCC						V
BCL2L11						V
EGF						V
+ 05212: Pancreatic cancer	0	1.6	0.8	2	0.6	0.9	0.2	0.2
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
RB1		V			V
TGFBR1		V
POLK		V	V		V
KRAS			V		V
RAC1			V		V
RAC3			V		V
RELA			V
PLD1			V		V
TGFA			V		V
TGFB3			V		V
BRCA2			V		V
RPS6KB1			V		V
PIK3R2				V		V
RAC2				V		V
NFKB1				V		V
BAD				V		V
BCL2L1				V		V
ARAF				V		V
MAPK1				V		V
STAT3				V
CDK4				V		V
E2F1				V		V
SMAD3				V		V
EGFR				V
MTOR				V		V
RPS6KB2				V		V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
SMAD2					V
EGF						V
VEGFA							V
RAD51								V
+ 05225: Hepatocellular carcinoma	2.6	1.8	0.7	3.4	1.1	2.4	0.1	1
LEF1	V					V
TCF7	V					V
APC2	V		V		V
WNT10B	V					V
WNT5B	V					V
GSTT2	V
GSTT2B	V
DPF1	V					V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
PTEN		V	V		V
FZD7		V		V
RB1		V			V
POLK		V	V		V
TGFBR1		V
MET		V			V
ARID2		V	V		V
NFE2L2		V			V
PHF10		V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
RPS6KB1			V		V
MYC			V		V
TCF7L2			V
TCF7L1			V		V
APC			V		V
DVL3			V		V
LRP5			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
TGFA			V		V
PLCG1			V		V
TGFB3			V		V
SMARCA2			V		V
GSTO2			V
BRD7			V		V
EGFR				V
HRAS				V		V
ARAF				V		V
MAP2K2				V		V
MAPK1				V		V
SHC1				V		V
GRB2				V		V
MTOR				V		V
RPS6KB2				V		V
PIK3R2				V		V
AXIN1				V		V
DVL1				V		V
DVL2				V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
E2F1				V		V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
PLCG2				V		V		V
PRKCG				V		V
ELK1				V		V
SMAD3				V		V
ARID1A				V
SMARCB1				V		V
TERT				V		V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
TXNRD1				V
BAD				V		V
BCL2L1				V		V
CDK4				V		V
SOS1					V
SOS2					V
CTNNB1					V
SMAD2					V
ARID1B					V
GAB1					V
WNT4						V
WNT3A						V
SMARCA4						V
GSTT1						V
+ 05226: Gastric cancer	2	1.3	0.9	1.5	1	2	0.4	0.5
LEF1	V					V
TCF7	V					V
APC2	V		V		V
WNT10B	V					V
WNT5B	V					V
RARB	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
FZD7		V		V
POLK		V	V		V
TGFBR1		V
MET		V			V
CCNE2		V			V			V
RB1		V			V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
RPS6KB1			V		V
MYC			V		V
TCF7L2			V
TCF7L1			V		V
APC			V		V
DVL3			V		V
LRP5			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
TGFB3			V		V
CTNNA1			V		V
CDKN1B			V
FGF20			V		V
FGF17			V		V
HRAS				V		V
ARAF				V		V
MAP2K2				V		V
MAPK1				V		V
SHC1				V		V
GRB2				V		V
MTOR				V		V
RPS6KB2				V		V
PIK3R2				V		V
AXIN1				V		V
DVL1				V		V
DVL2				V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
SMAD3				V		V
TERT				V		V
CCNE1				V		V
CDK2				V		V
E2F1				V		V
SHH				V		V
RXRB				V		V
EGFR				V
SOS1					V
SOS2					V
CTNNB1					V
SMAD2					V
GAB1					V
WNT4						V
WNT3A						V
CDX2						V
FGFR2						V
FGF6						V
FGF8						V
FGF22						V
EGF						V
JUP							V
+ 05214: Glioma	0	1.6	0.8	3	0.8	1.8	0.6	0.2
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
PTEN		V	V		V
RB1		V			V
POLK		V	V		V
TGFA			V		V
CALM1			V		V
CALML4			V
CAMK2D			V		V
SHC2			V		V		V
SHC4			V		V
PLCG1			V		V
KRAS			V		V
PDGFA				V		V
IGF1				V		V
EGFR				V
CAMK4				V
CAMK2B				V
CAMK1				V		V
PRKCG				V		V
SHC1				V		V
GRB2				V		V
ARAF				V		V
MAP2K2				V		V
MAPK1				V		V
PIK3R2				V		V
MTOR				V		V
TP53				V		V
CDK4				V		V
E2F1				V		V
PLCG2				V		V		V
HRAS				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
SOS1					V
SOS2					V
EGF						V
CALML3						V
PDGFB							V
+ 05216: Thyroid cancer	1.5	0.2	1.1	1.6	0.5	1.6	0	0
LEF1	V					V
TCF7	V					V
POLK		V	V		V
KRAS			V		V
MYC			V		V
CCDC6			V
TPR			V		V
TCF7L2			V
TCF7L1			V		V
HRAS				V		V
MAPK1				V		V
MAP2K2				V		V
RXRB				V		V
RET				V		V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
CTNNB1					V
+ 05221: Acute myeloid leukemia	2.2	0.6	0.7	2.8	0.5	2.1	1.2	0.3
CCNA1	V		V		V		V
LEF1	V					V
TCF7	V					V
BCL2A1	V					V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
KRAS			V		V
CEBPA			V		V
MYC			V		V
RELA			V
TCF7L2			V
TCF7L1			V		V
RPS6KB1			V		V
ZBTB16				V		V
FLT3				V
PPARD				V		V
NFKB1				V		V
STAT3				V
STAT5B				V		V
HRAS				V		V
BAD				V		V
PIM2				V		V
RPS6KB2				V		V
GRB2				V		V
MTOR				V		V
EIF4EBP1				V		V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
CEBPE				V		V
CD14				V		V
SOS1					V
SOS2					V
DUSP6					V		V
JUP							V
+ 05220: Chronic myeloid leukemia	0	1.6	0.8	2.2	0.4	1.3	0.2	0
TGFBR1		V
RB1		V			V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
POLK		V	V		V
TGFB3			V		V
CTBP1			V
MYC			V		V
RELA			V
CDKN1B			V
SHC2			V		V		V
SHC4			V		V
GAB2			V
KRAS			V		V
BCL2L1				V		V
BCR				V		V
TP53				V		V
STAT5B				V		V
NFKB1				V		V
BAD				V		V
CDKN1A				V		V
GRB2				V		V
SHC1				V		V
E2F1				V		V
SMAD3				V		V
CDK4				V		V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
GADD45A				V		V
BAX				V		V
MECOM					V
SOS1					V
SOS2					V
+ 05217: Basal cell carcinoma	3.9	1	1	1.8	0.4	2.5	0.7	0.8
BMP2	V		V
WNT10B	V					V
WNT5B	V					V
APC2	V		V		V
HHIP	V		V
LEF1	V					V
TCF7	V					V
BMP4		V					V
FZD7		V		V
GLI2		V			V
POLK		V	V		V
APC			V		V
DVL3			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
TCF7L2			V
TCF7L1			V		V
PTCH2				V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
SHH				V		V
SUFU				V		V
AXIN1				V		V
DVL1				V		V
DVL2				V		V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
CTNNB1					V
PTCH1						V
WNT4						V
WNT3A						V
+ 05218: Melanoma	0	2.1	0.3	1.4	0.4	1.3	0.2	0
PTEN		V	V		V
MET		V			V
RB1		V			V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
POLK		V	V		V
FGF20			V		V
PDGFC			V		V
PDGFD			V		V
FGF17			V		V
KRAS			V		V
CDK4				V		V
EGFR				V
IGF1				V		V
PDGFA				V		V
BAD				V		V
CDKN1A				V		V
TP53				V		V
E2F1				V		V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
GADD45A				V		V
BAX				V		V
EGF						V
FGF6						V
FGF8						V
FGF22						V
PDGFB							V
+ 05211: Renal cell carcinoma	0	2.1	0.2	1.3	1.3	0.4	0.6	0
ARNT2		V		V
MET		V			V
BUB1B-PAK6		V		V
PAK6		V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
TGFB3			V		V
CREBBP			V		V
HIF1A			V		V
TGFA			V		V
RAC1			V		V
KRAS			V		V
EGLN2				V		V
FH				V		V
GRB2				V		V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
BAD				V		V
TFE3				V		V
CDKN1A				V		V
EGLN3					V
EGLN1					V
SOS1					V
SOS2					V
GAB1					V
RAP1A					V
FLCN						V
PAK1						V
VEGFA							V
PDGFB							V
+ 05219: Bladder cancer	0.7	0.2	0.2	3.6	0	3.1	0.5	1.2
MMP1	V		V			V		V
RB1		V			V
MYC			V		V
FGFR3			V
KRAS			V		V
HRAS				V		V
MMP2				V		V
MMP9				V		V
TYMP				V		V
CXCL8				V		V		V
EGFR				V
CDKN1A				V		V
RASSF1				V		V
DAPK2				V		V
TP53				V		V
E2F1				V		V
CDK4				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
SRC				V		V
EGF						V
VEGFA							V
+ 05215: Prostate cancer	1.2	2.2	0.6	2.4	1.2	2	0.4	0.5
LEF1	V					V
TCF7	V					V
MMP3	V					V		V
PTEN		V	V		V
CREB1		V			V
CREB5		V			V
CCNE2		V			V			V
RB1		V			V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
ZEB1		V	V		V
RELA			V
CDKN1B			V
TCF7L2			V
TCF7L1			V		V
CREBBP			V		V
KRAS			V		V
PDGFC			V		V
TGFA			V		V
PDGFD			V		V
SPINT1			V		V
SRD5A2				V		V
NFKB1				V		V
NKX3-1				V		V
CDKN1A				V		V
CDK2				V		V
E2F1				V		V
HRAS				V		V
TP53				V		V
EGFR				V
BAD				V		V
CCNE1				V		V
IGF1				V		V
INS				V		V
PDGFA				V		V
GRB2				V		V
MTOR				V		V
PIK3R2				V		V
GSTP1				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
TMPRSS2				V
MMP9				V		V
PLAT				V		V
CTNNB1					V
SOS1					V
SOS2					V
HSP90AA1					V
HSP90B1					V
FGFR2						V
EGF						V
PDGFB							V
PLAU							V
+ 05213: Endometrial cancer	1.8	1.6	1.2	1.8	1.3	1.6	0	0
APC2	V		V		V
LEF1	V					V
TCF7	V					V
PTEN		V	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
POLK		V	V		V
KRAS			V		V
APC			V		V
CTNNA1			V		V
TCF7L2			V
TCF7L1			V		V
MYC			V		V
HRAS				V		V
AXIN1				V		V
BAD				V		V
GRB2				V		V
ELK1				V		V
EGFR				V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
CTNNB1					V
SOS1					V
SOS2					V
EGF						V
+ 05224: Breast cancer	2.5	0.7	1.6	1.5	1.2	2.4	0.1	0.2
FOS	V		V
LEF1	V					V
TCF7	V					V
APC2	V		V		V
WNT10B	V					V
WNT5B	V					V
HEYL	V					V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
PTEN		V	V		V
FZD7		V		V
RB1		V			V
POLK		V	V		V
ESR2			V		V
NCOA3			V		V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
NOTCH2			V		V
NOTCH3			V		V
RPS6KB1			V		V
MYC			V		V
TCF7L2			V
TCF7L1			V		V
APC			V		V
DVL3			V		V
LRP5			V		V
FZD3			V		V
FZD1			V		V		V
FZD6			V		V
BRCA2			V		V
FGF20			V		V
FGF17			V		V
HEY1			V		V
EGFR				V
HRAS				V		V
ARAF				V		V
MAP2K2				V		V
MAPK1				V		V
SHC1				V		V
GRB2				V		V
NOTCH1				V		V
MTOR				V		V
RPS6KB2				V		V
IGF1				V		V
DLL4				V		V
PGR				V		V
PIK3R2				V		V
AXIN1				V		V
DVL1				V		V
DVL2				V		V
WNT6				V		V
WNT8B				V		V		V
WNT2B				V		V		V
WNT10A				V		V
CDK4				V		V
E2F1				V		V
CDKN1A				V		V
NFKB2				V		V
TP53				V		V
GADD45A				V		V
BAX				V		V
SOS1					V
SOS2					V
CTNNB1					V
DLL3						V
DLL1						V
WNT4						V
WNT3A						V
TNFSF11						V
EGF						V
FGF6						V
FGF8						V
FGF22						V
+ 05222: Small cell lung cancer	0.7	2.7	1.6	2.4	1	1.2	0.4	1
RARB	V		V
PTGS2	V		V		V
CCNE2		V			V			V
ITGAV		V	V		V
AKT3		V
PTEN		V	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
BIRC3		V			V			V
XIAP		V			V
RB1		V			V
POLK		V	V		V
ITGA2			V		V
CDKN1B			V
APAF1			V		V
MYC			V		V
FHIT			V
COL4A4			V		V
COL4A5			V		V
COL4A6			V
FN1			V		V		V
LAMA5			V		V		V
RELA			V
CCNE1				V		V
CDK2				V		V
ZBTB17				V		V
RXRB				V		V
PIK3R2				V		V
LAMC3				V		V
COL4A2				V		V
LAMA4				V
LAMB3				V		V
LAMC2				V		V
BCL2L1				V		V
TRAF1				V		V
TRAF2				V		V
TRAF3				V		V
TRAF4				V		V
E2F1				V		V
CDK4				V		V
NFKB1				V		V
BAX				V		V
CASP3				V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
ITGB1					V
LAMB4						V
SKP2								V
+ 05223: Non-small cell lung cancer	0.4	1.4	0.3	3	0.4	2.1	0	0.3
RARB	V		V
AKT3		V
PIK3CA		V	V		V
PIK3R1		V	V		V
RB1		V			V
POLK		V	V		V
KRAS			V		V
PLCG1			V		V
TGFA			V		V
FHIT			V
PRKCG				V		V
BAD				V		V
PIK3R2				V		V
CDK4				V		V
E2F1				V		V
HRAS				V		V
PLCG2				V		V		V
EGFR				V
GRB2				V		V
RXRB				V		V
RASSF1				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
STAT3				V
STAT5B				V		V
TP53				V		V
CDKN1A				V		V
GADD45A				V		V
BAX				V		V
SOS1					V
SOS2					V
EML4					V
EGF						V
JAK3						V
+ 6.12 Drug resistance: antineoplastic	0.6	2.5	1.3	5.2	1.6	4	0.9	1.7
+ 01521: EGFR tyrosine kinase inhibitor resistance	0	1.1	1.4	3.3	1.6	2.7	1.5	0.6
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
PTEN		V	V		V
MET		V			V
RPS6KB1			V		V
TGFA			V		V
SHC2			V		V		V
SHC4			V		V
PLCG1			V		V
KRAS			V		V
NF1			V		V
KDR			V
FGFR3			V
PDGFC			V		V
PDGFD			V		V
NRG2			V		V
EGFR				V
EIF4EBP1				V		V
RPS6KB2				V		V
MTOR				V		V
BAD				V		V
GRB2				V		V
SHC1				V		V
PRKCG				V		V
PLCG2				V		V		V
PIK3R2				V		V
MAPK1				V		V
MAP2K2				V		V
ARAF				V		V
HRAS				V		V
STAT3				V
JAK2				V		V
BAX				V		V
BCL2L1				V		V
IGF1				V		V
PDGFA				V		V
SRC				V		V
IL6				V		V
EIF4E1B				V		V	V
NRG1				V		V
GAB1					V
SOS1					V
SOS2					V
GAS6					V
EGF						V
FGFR2						V
BCL2L11						V
IL6R						V		V
VEGFA							V
PDGFB							V
+ 01524: Platinum drug resistance	0.9	2.8	0.7	2.1	1.4	1.2	0.2	1.2
GSTT2	V
GSTT2B	V
BIRC3		V			V			V
XIAP		V			V
ATP7A		V	V		V
TOP2A		V			V
TOP2B		V	V		V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
REV3L		V			V
ATM			V		V
APAF1			V		V
FADD			V		V
FAS			V		V
BBC3			V		V		V
GSTO2			V
MAP3K5			V		V
TP53				V		V
CASP3				V
BAD				V		V
BIRC5				V		V
BAX				V		V
BCL2L1				V		V
GSTA5				V		V
GSTA1				V		V		V
GSTA2				V		V		V
GSTA3				V		V
GSTM1				V
GSTM2				V
GSTM4				V		V
GSTM5				V		V
GSTP1				V		V
PIK3R2				V		V
MAPK1				V		V
CDKN1A				V		V
PMAIP1					V
MSH2					V
FASLG						V
ABCC2						V
GSTT1						V
+ 01523: Antifolate resistance	0	0.3	0.2	1	0.1	0.8	0	1.5
TNF		V		V		V		V
ABCC5			V		V
DHFR2			V		V
RELA			V
ATIC				V		V
NFKB1				V		V
IL6				V		V
IL1B				V		V		V
ALOX12				V		V
ABCC4					V
ABCC2						V
+ 01522: Endocrine resistance	0.2	0.8	0.3	4	0.2	3.2	0.1	0.1
FOS	V		V
PRKACB		V			V
PIK3CA		V	V		V
PIK3R1		V	V		V
AKT3		V
RB1		V			V
ESR2			V		V
NCOA3			V		V
KRAS			V		V
SHC2			V		V		V
SHC4			V		V
NOTCH2			V		V
NOTCH3			V		V
CDKN1B			V
RPS6KB1			V		V
GPER1				V
SRC				V		V
MMP2				V		V
MMP9				V		V
EGFR				V
CARM1				V		V
PRKACG				V		V
HRAS				V		V
ARAF				V		V
MAP2K2				V		V
MAPK1				V		V
SHC1				V		V
GRB2				V		V
ADCY1				V		V
ADCY2				V		V		V
PIK3R2				V		V
MAPK14				V
MAPK12				V		V
NOTCH1				V		V
TP53				V		V
CDKN2C				V		V
CDKN1A				V		V
CDK4				V		V
E2F1				V		V
MTOR				V		V
RPS6KB2				V		V
IGF1				V		V
BIK				V		V
BAD				V		V
BAX				V		V
DLL4				V		V
SOS1					V
SOS2					V
PRKACA						V
MAPK11						V
MAPK13						V
DLL3						V
DLL1						V

**Save / Export**
META-Z-score:	download
Z-score:	download
Genes in pathway/subsystem/system:	download