Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	G1(165)	G2(1011)	G5(156)	G1+G2+G5(1172)	G6(474)	Flu_cellline(293)	Flu_human_42,90(467)	Flu_human_18(333)	Cytokine(258)	NAD_GO,str(624)	NAD_nonMeta(267)	SNP(17)
	98/157	393/949	92/148	487/1103	229/455	188/292	148/399	111/274	206/258	467/588	117/238	14/17
+ 1. Metabolism	2.8	4	2.5	4.4	8.3	7.5	2.2	2.5	1.5	40.8	0	2.3
+ 1.0 Global and overview maps	1.9	2.2	1.9	2.6	4.8	7.3	0.7	0.4	0.1	28.8	0	0.4
+ 01100: Metabolic pathways	0.9	0.4	0.8	0.6	3.6	1.9	0	0.1	0	30.3	0	0.9
TYMP	V		V	V
NME2	V			V
BLVRA	V		V	V						V
MTHFD2	V		V	V						V
MTHFD1	V		V	V						V
GAPDH	V		V	V						V
ALOX12	V		V	V						V
TALDO1	V		V	V						V
PCBD1	V		V	V
ACLY	V		V	V
COX7B	V		V	V						V
ATP6V0E1	V		V	V
NDUFB3	V		V	V						V
OXSM		V		V
HADHA		V		V						V
ELOVL5		V		V
TECR		V		V						V
ALDOA		V		V		V				V
SHMT2		V		V
GPX4		V		V
PGM1		V		V						V
CDIPT		V		V
MIF		V		V					V
ACADM		V		V
DCK		V		V
PDE6D		V		V
GMPS		V		V
MDH2		V		V						V
ESD		V		V
GRHPR		V		V						V
GLO1		V		V
HAGH		V		V
DPM3		V		V
GPI		V		V					V
HMOX1		V		V						V
POMGNT1		V		V
GALE		V		V						V
SMS		V		V
GAMT		V		V
PGD		V		V	V					V
CRYL1		V		V						V
UXS1		V		V						V
FAHD1		V		V
ACADVL		V		V
ACSL3		V		V
EBP		V		V
CMPK1		V		V
PLA2G12A		V		V
PAFAH1B2		V		V
PAFAH1B3		V		V
PTDSS1		V		V
FDPS		V		V
PIGC		V		V
ST6GALNAC6		V		V
PPCS		V		V
ACYP2		V		V
HSD17B10		V		V						V
ADPGK		V		V
GATB		V		V
PRPS1		V		V
GART		V		V
SUCLG2		V		V
GALM		V		V
PIGX		V		V
C1GALT1		V		V
B3GALT6		V		V
VKORC1L1		V		V		V
VKORC1		V		V		V
QDPR		V		V						V
UQCRHL		V		V
UQCRB		V		V
UQCRH		V		V
COX7A2L		V		V						V
ATP6V1G1		V		V
NDUFA11		V		V						V
NDUFA6		V		V						V
NDUFA10		V		V						V
NDUFC1		V		V	V					V
NDUFS5		V		V						V
NDUFB11		V		V						V
SDHD					V
GMPPB					V
HSD17B4					V					V
ACOX1					V
RRM2					V
MGST1					V
GSTO1					V
OPLAH					V
HK1					V
HK3					V
CAT					V					V
UPP1					V
CDA					V
NME3					V
NUDT16					V
GMPR					V					V
CA2					V
ACSS2					V
ELOVL1					V
GAA					V
BLVRB					V					V
NFS1					V
LPIN2					V
IDO1					V
PGK1					V					V
ASRGL1					V
PPT1					V
FBP1					V
CMPK2					V
SEPHS2					V
GPAT3					V
SPTLC2					V
ALOX5					V
BST1					V					V
CD38					V					V
MGLL					V
GBA					V
ST6GALNAC4					V
PNPO					V
PANK4					V
GK					V
PCK2					V
GNS					V
HPSE					V
IDH1					V	V				V
HYAL2					V
AHCY					V					V
GYG1					V
C1GALT1C1					V
GCH1					V
DGUOK					V
ATP6V1E1					V
CBR4						V				V
KYAT3						V
DLD						V				V
AOC2						V
AOC3						V
AOC1						V
AADAT						V
GOT1						V
GOT2						V
ENPP1						V				V
ADA						V
ACOD1						V
L2HGDH						V				V
DLST						V
TAT						V
GPT2						V
PAFAH1B1						V
PTGS1						V
ENO1						V
IDH2						V				V
OGDH						V				V
SQOR						V
NDUFS7						V				V
NDUFS2						V				V
NDUFA13						V				V
PIP5K1A							V	V
PIK3C2G							V
BCAT1							V
UGT1A6							V
DPYS							V	V
PDE11A							V
PDE4A							V
ADCY2							V
ADCY5							V
AK7							V
ACP1							V
ACADL							V	V
CYP19A1							V
PNLIPRP2							V
ALDH1A2							V			V
GPX8								V
PLCE1								V
GAD1								V
CA6								V
FUT9								V
BHMT2								V
DMGDH								V
PLA2G2F								V
TUSC3								V
MAN1C1								V
OGDHL								V		V
P4HA3								V
ENPP3									V	V
DBH									V
PLA2G5									V
ASAH2									V
NAMPT									V	V
FASN										V
MCAT										V
HSD17B8										V
MECR										V
SDHA										V
EHHADH										V
HADH										V
CYP1A2										V
CYP2A6										V
XDH										V
FADS1										V
HSD17B12										V
ALDOB										V
AMT										V
MTHFR										V
GSR										V
GLS										V
ALDH2										V
ALDH3A1										V
ALDH1B1										V
ALDH1A3										V
ALDH3B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
PGM2										V
HK2										V
PIK3CD										V
PIK3CG										V
KYNU										V
AFMID										V
ASPDH										V
NOS1										V
NOS2										V
NOS3										V
ALDH4A1										V
CAD										V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
PNP										V
NT5E										V
NT5C3A										V
UMPS										V
ITPA										V
GMPR2										V
HDDC3										V
IMPDH1										V
IMPDH2										V
SHPK										V
MDH1										V
ADH5										V
DERA										V
RBKS										V
MIOX										V
PFKFB1										V
PFKFB2										V
TIGAR										V
HADHB										V
DHDH										V
DLAT										V
PDHA1										V
PDHA2										V
PDHB										V
PDHX										V
HMOX2										V
COX10										V
COX15										V
DHCR24										V
CYP1A1										V
CYP2C8										V
CYP2C9										V
CYP3A4										V
CYP26A1										V
CYP26B1										V
AKR1B1										V
AKR1B10										V
PFKL										V
PFKM										V
DGKK										V
DGKA										V
DGKB										V
DGKG										V
DGKH										V
DGKQ										V
DGKZ										V
DGKE										V
DGKD										V
DGKI										V
PAPSS2										V
PAPSS1										V
HSD11B1										V
HSD11B2										V
ALDH6A1										V
HIBADH										V
ACADS										V
HSD3B1										V
HSD3B2										V
CYP7A1										V
MTHFD1L										V
FDFT1										V
PGK2										V
PGLS										V
DCXR										V
UGDH										V
AKR1A1										V
GMDS										V
TSTA3										V
ALDH5A1										V
PHGDH										V
MAT2B										V
CDO1										V
DHTKD1										V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH6										V
ADH7										V
TYR										V
HAAO										V
ALDH8A1										V
AOX1										V
ALDH18A1										V
ACMSD										V
BDH2										V
BDH1										V
SQLE										V
CYP51A1										V
TM7SF2										V
MSMO1										V
NSDHL										V
HSD17B7										V
SC5D										V
DHCR7										V
HSD3B7										V
AKR1D1										V
AKR1C4										V
CYP27A1										V
CYP17A1										V
HSD17B3										V
HSD17B2										V
HSD17B6										V
AKR1C3										V
HSD17B1										V
CYP2R1										V
CYP27B1										V
RPIA										V
TKT										V
RPE										V
RPEL1										V
ME3										V
ME1										V
DHODH										V
DPYD										V
AGK										V
KDSR										V
SMPD3										V
SMPD1										V
CYP2J2										V
CYP4A11										V
CYP4A22										V
CYP4F3										V
CYP4F2										V
PTGS2										V
CBR1										V
CBR3										V
PTGIS										V
CYP2C19										V
CYP2E1										V		V
QPRT										V
NMNAT2										V
NMNAT3										V
NMNAT1										V
NUDT12										V
NADSYN1										V
NAPRT										V
NADK2										V
NNT										V
NADK										V
NNMT										V
SPHK2										V
SPHK1										V
PGAM4										V
PGAM1										V
PGAM2										V
AASS										V
ENO2										V
ENO4										V
GCK										V
GLUD1										V
GLUD2										V
COQ6										V
COQ7										V
SORD										V
KMO										V
IDH3A										V
IDH3B										V
IDH3G										V
ALDH1A1										V
DHRS9										V
DHRS4										V
RDH12										V
RDH10										V
RDH8										V
RDH11										V
RDH16										V
DHRS3										V
AHCYL1										V
AHCYL2										V
NMRK2										V
NMRK1										V
NQO1										V
DHFR										V
SPR										V
RFK										V
G6PD										V
ISYNA1										V
H6PD										V
GAPDHS										V
PYCR2										V
PYCR1										V
HMGCR										V
COX17										V
COX6B1										V
COX6C										V
COX7A1										V
COX7A2										V
COX8A										V
COX7B2										V
COX8C										V
COX4I2										V
NDUFC2-KCTD14										V
NDUFA1										V
NDUFA2										V
NDUFA3										V
NDUFA4										V
NDUFA5										V
NDUFA7										V
NDUFA8										V
NDUFA9										V
NDUFAB1										V
NDUFB1										V
NDUFB2										V
NDUFB4										V
NDUFB5										V
NDUFB7										V
NDUFB8										V
NDUFB9										V
NDUFB10										V
NDUFC2										V
NDUFS1										V
NDUFS3										V
NDUFV1										V
NDUFS4										V
NDUFS6										V
NDUFS8										V
NDUFV2										V
NDUFV3										V
NDUFA12										V
NAT2												V
+ 01200: Carbon metabolism	1.8	1.9	1.9	2.4	3.5	4.4	0	0.2	0.3	14.5	0	0
GAPDH	V		V	V						V
TALDO1	V		V	V						V
ME2	V		V	V						V
ALDOA		V		V		V				V
ADPGK		V		V
GPI		V		V					V
PGD		V		V	V					V
MDH2		V		V						V
SUCLG2		V		V
SHMT2		V		V
PRPS1		V		V
ESD		V		V
HADHA		V		V						V
PGK1					V					V
FBP1					V
HK1					V
HK3					V
SDHD					V
IDH1					V	V				V
ACOX1					V
ACSS2					V
CAT					V					V
ENO1						V
DLD						V				V
IDH2						V				V
DLST						V
OGDH						V				V
GOT1						V
GOT2						V
GPT2						V
OGDHL								V		V
ALDOB										V
TKT										V
PGAM4										V
PGAM1										V
PGAM2										V
PGK2										V
RPE										V
RPEL1										V
PFKL										V
PFKM										V
GCK										V
HK2										V
G6PD										V
H6PD										V
PGLS										V
RPIA										V
ENO2										V
ENO4										V
DLAT										V
PDHA1										V
PDHA2										V
PDHB										V
MDH1										V
SDHA										V
IDH3A										V
IDH3B										V
IDH3G										V
PHGDH										V
MTHFR										V
AMT										V
ADH5										V
ME3										V
ME1										V
ACADS										V
EHHADH										V
ALDH6A1										V
GLUD1										V
GLUD2										V
+ 01210: 2-Oxocarboxylic acid metabolism	0	0	0	0	0.9	5.2	1	0	0	3.8	0	0
IDH1					V	V				V
GOT1						V
GOT2						V
GPT2						V
AADAT						V
IDH2						V				V
BCAT1							V
IDH3A										V
IDH3B										V
IDH3G										V
+ 01212: Fatty acid metabolism	0	2.3	0	2	2	0.6	0.4	0.6	0	6.1	0	0
OXSM		V		V
TECR		V		V						V
HADHA		V		V						V
ELOVL5		V		V
ACSL3		V		V
ACADM		V		V
ACADVL		V		V
ELOVL1					V
HSD17B4					V					V
ACOX1					V
PPT1					V
CBR4						V				V
ACADL							V	V
FASN										V
MCAT										V
HSD17B8										V
MECR										V
HSD17B12										V
HADHB										V
EHHADH										V
HADH										V
ACADS										V
FADS1										V
+ 01230: Biosynthesis of amino acids	1.5	0.4	1.6	0.8	0.6	4.3	0.3	0	0	9.7	0	0
GAPDH	V		V	V						V
TALDO1	V		V	V						V
ALDOA		V		V		V				V
PRPS1		V		V
SHMT2		V		V
PGK1					V					V
IDH1					V	V				V
ENO1						V
GOT1						V
GOT2						V
IDH2						V				V
GPT2						V
TAT						V
BCAT1							V
PGK2										V
PGAM4										V
PGAM1										V
PGAM2										V
ENO2										V
ENO4										V
ALDOB										V
PFKL										V
PFKM										V
TKT										V
RPE										V
RPEL1										V
RPIA										V
PHGDH										V
IDH3A										V
IDH3B										V
IDH3G										V
ALDH18A1										V
PYCR2										V
PYCR1										V
MAT2B										V
+ 1.1 Carbohydrate metabolism	1.2	3.3	1.2	3.3	5.2	3.1	0.6	0.8	1.1	23.9	0	0
+ 00010: Glycolysis / Gluconeogenesis	0.8	1.2	0.8	1.3	2.8	1.7	0	0	0.5	14.7	0	0
GAPDH	V		V	V						V
ALDOA		V		V		V				V
GPI		V		V					V
PGM1		V		V						V
GALM		V		V
ADPGK		V		V
FBP1					V
HK1					V
HK3					V
PGK1					V					V
PCK2					V
ACSS2					V
ENO1						V
DLD						V				V
ALDOB										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
AKR1A1										V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH5										V
ADH6										V
ADH7										V
PDHA1										V
PDHA2										V
PDHB										V
DLAT										V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
ENO2										V
ENO4										V
PGAM4										V
PGAM1										V
PGAM2										V
GAPDHS										V
PFKL										V
PFKM										V
PGM2										V
HK2										V
GCK										V
PGK2										V
+ 00020: Citrate cycle (TCA cycle)	1.2	0.8	1.3	1.2	2.1	3.9	0	0.9	0	8	0	0
ACLY	V		V	V
SUCLG2		V		V
MDH2		V		V						V
IDH1					V	V				V
PCK2					V
SDHD					V
DLD						V				V
OGDH						V				V
DLST						V
IDH2						V				V
OGDHL								V		V
IDH3A										V
IDH3B										V
IDH3G										V
MDH1										V
PDHA1										V
PDHA2										V
PDHB										V
DLAT										V
SDHA										V
+ 00030: Pentose phosphate pathway	1.2	2.4	1.3	2.7	1.4	0.9	0	0	1	8.8	0	0
TALDO1	V		V	V						V
GPI		V		V					V
PRPS1		V		V
ALDOA		V		V		V				V
PGD		V		V	V					V
PGM1		V		V						V
FBP1					V
RBKS										V
PGM2										V
DERA										V
TKT										V
RPIA										V
RPE										V
RPEL1										V
ALDOB										V
PFKL										V
PFKM										V
PGLS										V
G6PD										V
H6PD										V
+ 00040: Pentose and glucuronate interconversions	0	0.2	0	0.2	0	0	0.7	0	0	5.5	0	0
CRYL1		V		V						V
UGT1A6							V
RPE										V
RPEL1										V
AKR1B1										V
AKR1B10										V
DCXR										V
UGDH										V
DHDH										V
SORD										V
AKR1A1										V
+ 00051: Fructose and mannose metabolism	0	0.2	0	0.2	2.7	0.8	0	0	0	6.9	0	0
ALDOA		V		V		V				V
HK1					V
HK3					V
GMPPB					V
FBP1					V
AKR1B1										V
AKR1B10										V
SORD										V
HK2										V
PFKFB1										V
PFKFB2										V
TIGAR										V
TSTA3										V
GMDS										V
PFKL										V
PFKM										V
ALDOB										V
+ 00052: Galactose metabolism	0	1.3	0	1.1	2.1	0	0	0	0	5.2	0	0
PGM1		V		V						V
GALE		V		V						V
GALM		V		V
GAA					V
HK1					V
HK3					V
PFKL										V
PFKM										V
AKR1B1										V
AKR1B10										V
GCK										V
HK2										V
PGM2										V
+ 00053: Ascorbate and aldarate metabolism	0	0	0	0	0	0	0.8	0	0	4.4	0	0
UGT1A6							V
MIOX										V
UGDH										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
+ 00500: Starch and sucrose metabolism	0	0.6	0	0.5	2.6	0.8	0	0	1.7	3.4	0	0
PGM1		V		V						V
GPI		V		V					V
HK1					V
HK3					V
GAA					V
GYG1					V
ENPP1						V				V
ENPP3									V	V
HK2										V
PGM2										V
GCK										V
+ 00520: Amino sugar and nucleotide sugar metabolism	0	1.3	0	1	1.6	0	0	0	0.7	6.5	0	0
GALE		V		V						V
UXS1		V		V						V
PGM1		V		V						V
GPI		V		V					V
HK1					V
HK3					V
GMPPB					V
HK2										V
CYB5R3										V
CYB5R4										V
CYB5R2										V
CYB5R1										V
CYB5RL										V
UGDH										V
PGM2										V
GMDS										V
TSTA3										V
GCK										V
+ 00620: Pyruvate metabolism	1.1	2	1.1	2.3	1.2	0.8	0	0	0	9.7	0	0
ME2	V		V	V						V
GLO1		V		V
HAGH		V		V
MDH2		V		V						V
GRHPR		V		V						V
ACYP2		V		V
PCK2					V
ACSS2					V
DLD						V				V
PDHA1										V
PDHA2										V
PDHB										V
ME3										V
ME1										V
MDH1										V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
DLAT										V
+ 00630: Glyoxylate and dicarboxylate metabolism	0	1.4	0	1.2	1.4	0.9	0	0	0	4.3	0	0
GRHPR		V		V						V
MDH2		V		V						V
SHMT2		V		V
CAT					V					V
ACSS2					V
DLD						V				V
AFMID										V
MDH1										V
AMT										V
+ 00640: Propanoate metabolism	0	0.7	0	0.5	1.3	0.8	0	0	0	5.5	0	0
HADHA		V		V						V
SUCLG2		V		V
ACSS2					V
ACOX1					V
DLD						V				V
ALDH6A1										V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
EHHADH										V
ACADS										V
+ 00650: Butanoate metabolism	0	0.3	0	0.2	0	0.9	0	1	0	4.8	0	0
HADHA		V		V						V
L2HGDH						V				V
GAD1								V
BDH2										V
BDH1										V
EHHADH										V
HADH										V
ACADS										V
ALDH5A1										V
+ 00562: Inositol phosphate metabolism	0	0	0	0	0	0	0.7	1.1	0	1.8	0	0
CDIPT		V		V
PIP5K1A							V	V
PIK3C2G							V
PLCE1								V
ISYNA1										V
MIOX										V
PIK3CD										V
PIK3CG										V
ALDH6A1										V
+ 1.2 Energy metabolism	1.3	1.2	1.3	1.7	0.9	1.4	0	0.7	0	10.3	0	0
+ 00190: Oxidative phosphorylation	2.3	2.2	2.3	2.9	0.5	1	0	0	0	14.1	0	0
NDUFB3	V		V	V						V
COX7B	V		V	V						V
ATP6V0E1	V		V	V
PPA1	V		V	V
NDUFC1		V		V	V					V
NDUFA11		V		V						V
NDUFA10		V		V						V
NDUFA6		V		V						V
NDUFS5		V		V						V
NDUFB11		V		V						V
COX7A2L		V		V						V
UQCRHL		V		V
UQCRB		V		V
UQCRH		V		V
ATP6V1G1		V		V
LHPP		V		V
ATP6V1E1					V
SDHD					V
NDUFS7						V				V
NDUFS2						V				V
NDUFA13						V				V
COX4I2										V
NDUFC2-KCTD14										V
NDUFC2										V
NDUFB10										V
NDUFB9										V
NDUFB8										V
NDUFB7										V
NDUFB6										V
NDUFB5										V
NDUFB4										V
NDUFB2										V
NDUFB1										V
NDUFAB1										V
NDUFA9										V
NDUFA8										V
NDUFA7										V
NDUFA5										V
NDUFA4										V
NDUFA3										V
NDUFA2										V
NDUFA1										V
NDUFV3										V
NDUFV2										V
NDUFV1										V
NDUFS8										V
NDUFS6										V
NDUFS4										V
NDUFS3										V
NDUFS1										V
COX17										V
COX15										V
NDUFA12										V
COX8A										V
COX8C										V
COX7B2										V
COX7A1										V
COX7A2										V
COX6C										V
COX6B1										V
SDHA										V
COX10										V
+ 00910: Nitrogen metabolism	0	0	0	0	1	0	0	1.2	0	1.7	0	0
CA2					V
CA6								V
GLUD1										V
GLUD2										V
+ 00920: Sulfur metabolism	0	0	0	0	0	1.5	0	0	0	2.1	0	0
SQOR						V
PAPSS2										V
PAPSS1										V
+ 1.3 Lipid metabolism	1	1.9	1.1	2	2.5	0.8	0.5	1.3	1.2	18.6	0	1.6
+ 00061: Fatty acid biosynthesis	0	1.2	0	1.1	0	1.2	0	0	0	3.8	0	0
OXSM		V		V
ACSL3		V		V
CBR4						V				V
FASN										V
MCAT										V
MECR										V
HSD17B8										V
+ 00062: Fatty acid elongation	1.3	1.5	1.3	1.8	1.5	0	0	0	0	3.8	0	0
ACOT7	V		V	V
HADHA		V		V						V
TECR		V		V						V
ELOVL5		V		V
PPT1					V
ELOVL1					V
MECR										V
HADHB										V
HADH										V
HSD17B12										V
+ 00071: Fatty acid degradation	0	1.4	0	1.2	0.5	0	0.5	0.7	0	8.6	0	0
HADHA		V		V						V
ACADM		V		V
ACSL3		V		V
ACADVL		V		V
ACOX1					V
ACADL							V	V
ACADS										V
EHHADH										V
HADH										V
HADHB										V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH5										V
ADH6										V
ADH7										V
CYP4A11										V
CYP4A22										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
+ 00072: Synthesis and degradation of ketone bodies	0	0	0	0	0	0	0	0	0	2.1	0	0
BDH2										V
BDH1										V
+ 00100: Steroid biosynthesis	0	0.5	0	0.4	0	0	0	0	0	7.6	0	0
EBP		V		V
SC5D										V
DHCR7										V
DHCR24										V
CYP51A1										V
TM7SF2										V
NSDHL										V
MSMO1										V
HSD17B7										V
CYP2R1										V
CYP27B1										V
FDFT1										V
SQLE										V
+ 00120: Primary bile acid biosynthesis	0	0	0	0	1	0	0	0	0	6.2	0	0
HSD17B4					V					V
CYP46A1										V
CYP7B1										V
CYP7A1										V
AKR1D1										V
AKR1C4										V
CYP27A1										V
HSD3B7										V
CYP39A1										V
+ 00140: Steroid hormone biosynthesis	0	0	0	0	0	0	0.9	0	0	10.7	0	1.9
UGT1A6							V
CYP19A1							V
HSD17B1										V
HSD17B2										V
HSD17B12										V
HSD17B7										V
HSD17B8										V
HSD17B6										V
SULT2B1										V
CYP17A1										V
HSD3B1										V
HSD3B2										V
CYP7B1										V
CYP1A1										V
CYP1A2										V
AKR1C3										V
SRD5A1										V
SRD5A2										V
SRD5A3										V
AKR1C2										V
AKR1D1										V
AKR1C4										V
AKR1C1										V
HSD11B1										V
HSD11B2										V
DHRS11										V
HSD17B3										V
CYP7A1										V
CYP2E1										V		V
CYP3A4										V
+ 00561: Glycerolipid metabolism	0	0	0	0	1.9	0	0.4	0	0	7.7	0	0
LPIN2					V
MGLL					V
GPAT3					V
GK					V
PNLIPRP2							V
AGK										V
AKR1B1										V
AKR1B10										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
AKR1A1										V
DGKK										V
DGKA										V
DGKB										V
DGKG										V
DGKH										V
DGKQ										V
DGKZ										V
DGKE										V
DGKD										V
DGKI										V
+ 00564: Glycerophospholipid metabolism	0.6	0.4	0.6	0.5	0.4	0	0	0.3	0.3	5.2	0	0
LYPLA2	V		V	V
PTDSS1		V		V
PLA2G12A		V		V
CDIPT		V		V
LYPLA1		V		V
LPIN2					V
GPAT3					V
PLA2G2F								V
PLA2G5									V
CHAT										V
DGKK										V
DGKA										V
DGKB										V
DGKG										V
DGKH										V
DGKQ										V
DGKZ										V
DGKE										V
DGKD										V
DGKI										V
GPD1L										V
GPD1										V
GPD2										V
TAZ										V
+ 00565: Ether lipid metabolism	0	0.8	0	0.7	0	1.4	0	0.7	0.7	0	0	0
PAFAH1B2		V		V
PAFAH1B3		V		V
PLA2G12A		V		V
PAFAH1B1						V
ENPP2						V
PLA2G2F								V
PLA2G5									V
+ 00600: Sphingolipid metabolism	0	0	0	0	1	0	0	0	0.7	3	0	0
SPTLC2					V
GBA					V
ASAH2									V
SMPD3										V
SMPD1										V
CERK										V
KDSR										V
SPHK2										V
SPHK1										V
+ 00590: Arachidonic acid metabolism	0.8	0.1	0.9	0.2	0.3	0.5	0	1.2	0.6	6.3	0	1.9
ALOX12	V		V	V						V
PLA2G12A		V		V
ALOX5					V
PTGS1						V
GPX8								V
PLA2G2F								V
PLA2G5									V
CYP2J2										V
CYP2C9										V
CYP2C8										V
CYP4F3										V
CYP4F2										V
CYP4A11										V
CYP4A22										V
PTGS2										V
PTGIS										V
AKR1C3										V
CBR1										V
CBR3										V
CYP2C19										V
CYP2E1										V		V
+ 00591: Linoleic acid metabolism	0	0.3	0	0.2	0	0	0	1	1	4.3	0	2.3
PLA2G12A		V		V
PLA2G2F								V
PLA2G5									V
CYP1A2										V
CYP2C19										V
CYP2C8										V
CYP2C9										V
CYP2J2										V
CYP2E1										V		V
CYP3A4										V
+ 00592: alpha-Linolenic acid metabolism	0	0.4	0	0.3	0.8	0	0	1.1	1.1	0	0	0
PLA2G12A		V		V
ACOX1					V
PLA2G2F								V
PLA2G5									V
+ 01040: Biosynthesis of unsaturated fatty acids	1.3	0.9	1.3	1.3	2.2	0	0	0	0	2.6	0	0
ACOT7	V		V	V
TECR		V		V						V
ELOVL5		V		V
HSD17B4					V					V
ACOX1					V
ELOVL1					V
HSD17B12										V
FADS1										V
+ 1.4 Nucleotide metabolism	1.6	0.6	0.7	0.9	2.7	0.8	1.3	0.4	0.6	6.2	0	0
+ 00230: Purine metabolism	0.4	0.5	0	0.5	1.3	0.5	1.5	0	0.2	4.8	0	0
NME2	V			V
PRPS1		V		V
GART		V		V
GMPS		V		V
PDE6D		V		V
DCK		V		V
PGM1		V		V						V
RRM2					V
NME3					V
GMPR					V					V
DGUOK					V
NUDT16					V
ADA						V
ENPP1						V				V
PDE11A							V
ADCY2							V
ADCY5							V
AK7							V
PDE4A							V
ENPP3									V	V
XDH										V
NT5E										V
NT5C3A										V
PNP										V
GMPR2										V
IMPDH1										V
IMPDH2										V
HDDC3										V
PAPSS2										V
PAPSS1										V
ITPA										V
PGM2										V
+ 00240: Pyrimidine metabolism	1.8	0.3	0.9	0.8	2.5	0.6	0.4	0.6	0.6	4	0	0
NME2	V			V
TYMP	V		V	V
CMPK1		V		V
DCK		V		V
RRM2					V
NME3					V
CMPK2					V
UPP1					V
CDA					V
ENPP1						V				V
DPYS							V	V
ENPP3									V	V
CAD										V
UMPS										V
NT5E										V
NT5C3A										V
DPYD										V
PNP										V
DHODH										V
+ 1.5 Amino acid metabolism	0	1.1	0	0.9	0.7	8.9	0.9	0.8	0.8	16.3	0	0
+ 00250: Alanine, aspartate and glutamate metabolism	0	0	0	0	0.6	2.4	0	0.8	0	3.4	0	0
ASRGL1					V
GOT1						V
GOT2						V
GPT2						V
GAD1								V
CAD										V
ALDH5A1										V
GLUD1										V
GLUD2										V
GLS										V
ALDH4A1										V
+ 00260: Glycine, serine and threonine metabolism	0	1	0	0.8	0	2.3	0	0.8	0	4.2	0	0
GAMT		V		V
SHMT2		V		V
GRHPR		V		V						V
AOC2						V
AOC3						V
DLD						V				V
DMGDH								V
ALDH7A1										V
PHGDH										V
AMT										V
PGAM4										V
PGAM1										V
PGAM2										V
+ 00270: Cysteine and methionine metabolism	0	0.4	0	0.3	0.4	2.7	0.5	0.7	0	6	0	0
SMS		V		V
MDH2		V		V						V
AHCY					V					V
TAT						V
KYAT3						V
GOT1						V
GOT2						V
BCAT1							V
BHMT2								V
MAT2B										V
AHCYL1										V
AHCYL2										V
CDO1										V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
MDH1										V
PHGDH										V
+ 00280: Valine, leucine and isoleucine degradation	0	0.8	0	0.6	0	0.6	0.5	0	0	6.9	0	0
HADHA		V		V						V
HSD17B10		V		V						V
ACADM		V		V
DLD						V				V
BCAT1							V
EHHADH										V
HADHB										V
HADH										V
AOX1										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
ALDH6A1										V
HIBADH										V
ACADS										V
+ 00290: Valine, leucine and isoleucine biosynthesis	0	0	0	0	0	0	1.7	0	0	0	0	0
BCAT1							V
+ 00310: Lysine degradation	0	0.1	0	0	0.3	1.9	0.4	0	0	5.3	0	0
HADHA		V		V						V
PLOD1					V
AADAT						V
DLD						V				V
DLST						V
BBOX1							V
AASS										V
EHHADH										V
HADH										V
ALDH7A1										V
DHTKD1										V
ALDH9A1										V
EHMT2										V
ALDH2										V
ALDH1B1										V
ALDH3A2										V
+ 00220: Arginine biosynthesis	0	0	0	0	0	2.9	0	0	0	4.2	0	0
GOT1						V
GOT2						V
GPT2						V
GLS										V
NOS1										V
NOS2										V
NOS3										V
GLUD1										V
GLUD2										V
+ 00330: Arginine and proline metabolism	0	0.4	0	0.3	0	2.1	0	0.7	0	5.6	0	0
SMS		V		V
GAMT		V		V
AOC1						V
GOT1						V
GOT2						V
P4HA3								V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
NOS1										V
NOS2										V
NOS3										V
PYCR2										V
PYCR1										V
ALDH4A1										V
ALDH18A1										V
+ 00340: Histidine metabolism	0	0	0	0	0	1.1	0	0	0	5.2	0	0
AOC1						V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
+ 00350: Tyrosine metabolism	0	0.6	0	0.5	0	3.8	0	0	1.8	6.3	0	0
FAHD1		V		V
MIF		V		V					V
GOT1						V
GOT2						V
TAT						V
AOC2						V
AOC3						V
DBH									V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
TYR										V
AOX1										V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH5										V
ADH6										V
ADH7										V
+ 00360: Phenylalanine metabolism	0	0.6	0	0.5	0	4.7	0	0	1.3	2.5	0	0
MIF		V		V					V
AOC2						V
AOC3						V
TAT						V
GOT1						V
GOT2						V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
+ 00380: Tryptophan metabolism	0	0.2	0	0.1	1.1	3.5	0	0	0	9.1	0	0
HADHA		V		V						V
CAT					V					V
IDO1					V
DLD						V				V
DLST						V
AADAT						V
KYAT3						V
AOC1						V
EHHADH										V
HADH										V
CYP1A1										V
CYP1A2										V
AFMID										V
DHTKD1										V
ALDH8A1										V
ACMSD										V
HAAO										V
KYNU										V
KMO										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
AOX1										V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	0	0	4.1	0	0	0	0	0	0
TAT						V
GOT1						V
GOT2						V
+ 1.6 Metabolism of other amino acids	0	0.5	0	0.4	1.8	1.6	0.3	1.4	0	6.7	0	0
+ 00410: beta-Alanine metabolism	0	0.7	0	0.6	0.6	1.7	0.7	1.8	0	7	0	0
HADHA		V		V						V
SMS		V		V
ACOX1					V
AOC2						V
AOC3						V
DPYS							V	V
GAD1								V
ACADS										V
EHHADH										V
ALDH6A1										V
ALDH2										V
ALDH1B1										V
ALDH9A1										V
ALDH3A2										V
ALDH7A1										V
DPYD										V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
+ 00430: Taurine and hypotaurine metabolism	0	0	0	0	0	0	0	1.5	0	1.1	0	0
GAD1								V
CDO1										V
+ 00440: Phosphonate and phosphinate metabolism	0	0	0	0	0	0	0	0	0	0	0	0
+ 00450: Selenocompound metabolism	0	0	0	0	1	1.2	0	0	0	3.8	0	0
SEPHS2					V
KYAT3						V
TXNRD2										V
TXNRD3										V
TXNRD1										V
PAPSS2										V
PAPSS1										V
+ 00471: D-Glutamine and D-glutamate metabolism	0	0	0	0	0	0	0	0	0	3.6	0	0
GLUD1										V
GLUD2										V
GLS										V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0	0	0	0	0	0	0	0
+ 00480: Glutathione metabolism	0	0.6	0	0.5	3.1	1.3	0	0.6	0	2.2	0	0
GPX4		V		V
PGD		V		V	V					V
SMS		V		V
IDH1					V	V				V
OPLAH					V
MGST1					V
GSTO1					V
RRM2					V
IDH2						V				V
GPX8								V
G6PD										V
GSR										V
+ 1.7 Glycan biosynthesis and metabolism	0	1.1	0	0.9	1.8	0	0.2	1.6	0	0.1	0	0
+ 00510: N-Glycan biosynthesis	0	0.1	0	0.1	0.4	0	0	1.4	0	0.3	0	0
DPM3		V		V
DOLPP1					V
MAN1C1								V
TUSC3								V
SRD5A3										V
+ 00512: Mucin type O-glycan biosynthesis	0	0.3	0	0.2	0.7	0	0	0	0	0	0	0
C1GALT1		V		V
C1GALT1C1					V
+ 00515: Mannose type O-glycan biosynthesis	0	0.4	0	0.3	0	0	0	1.1	0	0	0	0
POMGNT1		V		V
FUT9								V
+ 00514: Other types of O-glycan biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	1.2	0	1	0	0	0	0	0	0	0	0
B3GALT6		V		V
CHST11		V		V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0	0.4	0	0.3	0	0	0.9	1.1	0	0	0	0
B3GALT6		V		V
HS6ST3							V	V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	0	0	0	0	0	0	0	0	0	0	0
+ 00531: Glycosaminoglycan degradation	0	0	0	0	2.6	0	0	0	0	0	0	0
HPSE					V
GNS					V
HYAL2					V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	1	0	0.9	0	0	0	0	0	0	0	0
PIGC		V		V
PIGX		V		V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0	0	0	0	0	0	0	1	0	0	0	0
FUT9								V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0	0	0	0	0	1.3	0	0	0	0
FUT9								V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0	0.6	0	0.5	1	0	0	0	0	0	0	0
ST6GALNAC6		V		V
ST6GALNAC4					V
+ 00511: Other glycan degradation	0	0	0	0	1.8	0	0	0	0	0	0	0
FUCA2					V
GBA					V
+ 1.8 Metabolism of cofactors and vitamins	1.4	1.5	1.4	2	2.1	2.1	2	0.7	1.4	13.1	0	0
+ 00730: Thiamine metabolism	0	0	0	0	1	0	2.1	0	0	0	0	0
NFS1					V
AK7							V
ACP1							V
+ 00740: Riboflavin metabolism	0	0	0	0	1.4	1.6	1.4	0	1.6	4	0	0
BLVRB					V					V
ENPP1						V				V
ACP1							V
ENPP3									V	V
RFK										V
+ 00750: Vitamin B6 metabolism	0	0	0	0	1.5	0	0	0	0	1.4	0	0
PNPO					V
AOX1										V
+ 00760: Nicotinate and nicotinamide metabolism	0	0	0	0	1.4	0.9	0	0	1.9	11.3	0	0
BST1					V					V
CD38					V					V
ENPP1						V				V
ENPP3									V	V
NAMPT									V	V
ASPDH										V
NUDT12										V
QPRT										V
NMRK2										V
NMRK1										V
PNP										V
NMNAT2										V
NMNAT3										V
NMNAT1										V
NADSYN1										V
NAPRT										V
NNMT										V
NADK2										V
NADK										V
NNT										V
AOX1										V
NT5E										V
NT5C3A										V
+ 00770: Pantothenate and CoA biosynthesis	0	0.5	0	0.4	0.9	1.1	1.9	1.2	1.2	2.3	0	0
PPCS		V		V
PANK4					V
ENPP1						V				V
DPYS							V	V
BCAT1							V
ENPP3									V	V
DPYD										V
+ 00780: Biotin metabolism	0	1.5	0	1.4	0	0	0	0	0	0	0	0
OXSM		V		V
+ 00785: Lipoic acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0
+ 00790: Folate biosynthesis	1.3	0.4	1.4	0.8	0.8	0	0	0	0	4.5	0	0
PCBD1	V		V	V
QDPR		V		V						V
GCH1					V
DHFR										V
SPR										V
AKR1B1										V
AKR1B10										V
CBR1										V
AKR1C3										V
+ 00670: One carbon pool by folate	2.5	1.1	2.6	2.2	0	0	0	0	0	4.3	0	0
MTHFD2	V		V	V						V
MTHFD1	V		V	V						V
GART		V		V
SHMT2		V		V
DHFR										V
MTHFR										V
AMT										V
MTHFD1L										V
+ 00830: Retinol metabolism	0	0	0	0	0	0	0.8	0.5	0	11.3	0	0
ALDH1A2							V			V
UGT1A6							V
LRAT								V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH5										V
ADH6										V
ADH7										V
ALDH1A1										V
AOX1										V
RDH10										V
RDH11										V
RDH5										V
RDH12										V
CYP26A1										V
CYP26B1										V
CYP3A4										V
CYP1A1										V
CYP1A2										V
RDH8										V
RDH16										V
DHRS9										V
DHRS4										V
DHRS3										V
CYP2A6										V
CYP4A11										V
CYP4A22										V
CYP2C8										V
CYP2C9										V
SDR16C5										V
HSD17B6										V
+ 00860: Porphyrin and chlorophyll metabolism	1.1	0.2	1.1	0.4	0.5	0	0.5	0.8	0	3.2	0	0
BLVRA	V		V	V						V
HMOX1		V		V						V
BLVRB					V					V
UGT1A6							V
HCCS								V
COX10										V
COX15										V
HMOX2										V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0	1.7	0	1.6	0	3.6	0	0	0	3	0	0
VKORC1L1		V		V		V
VKORC1		V		V		V
TAT						V
COQ6										V
COQ7										V
NQO1										V
+ 1.9 Metabolism of terpenoids and polyketides	0	0.4	0	0.3	1.6	0	0	0	0	0.7	0	0
+ 00900: Terpenoid backbone biosynthesis	0	0.4	0	0.3	1.6	0	0	0	0	0.7	0	0
FDPS		V		V
NUS1					V
PDSS1					V
HMGCR										V
+ 1.10 Biosynthesis of other secondary metabolites	0	0	0	0	2	0	0	0	0	4.4	0	2
+ 00232: Caffeine metabolism	0	0	0	0	0	0	0	0	0	3.6	0	2.8
CYP1A2										V
XDH										V
CYP2A6										V
NAT2												V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	0	0	2.8	0	0	0	0	2.6	0	0
HK1					V
HK3					V
HK2										V
GCK										V
+ 1.11 Xenobiotics biodegradation and metabolism	1.3	0.1	0.9	0.4	2.7	0	1	0.5	0	12.4	0	3.9
+ 00980: Metabolism of xenobiotics by cytochrome P450	0	0	0	0	0.6	0	0.7	0.4	0	8.8	0	1.9
MGST1					V
GSTO1					V
UGT1A6							V
SULT2A1							V	V
CYP2E1										V		V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH5										V
ADH6										V
ADH7										V
CYP1A1										V
CYP1A2										V
CYP3A4										V
AKR7A3										V
AKR7A2										V
AKR1C1										V
DHDH										V
HSD11B1										V
CBR1										V
CBR3										V
CYP2A6										V
CYP2D6										V
CYP2C9										V
+ 00982: Drug metabolism - cytochrome P450	0	0	0	0	0.7	0	0.3	0	0	8.9	0	1.9
MGST1					V
GSTO1					V
UGT1A6							V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
FMO1										V
FMO2										V
FMO3										V
FMO4										V
FMO5										V
CYP3A4										V
CYP2D6										V
CYP1A2										V
CYP2C19										V
CYP2C9										V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH5										V
ADH6										V
ADH7										V
CYP2A6										V
AOX1										V
CYP2E1										V		V
CYP2C8										V
+ 00983: Drug metabolism - other enzymes	2.2	0.1	1.5	0.7	3.5	0	0.7	0.4	0	3.8	0	3.1
TPMT	V		V	V
TYMP	V		V	V
NME2	V			V
GMPS		V		V
CMPK1		V		V
UPP1					V
CDA					V
CES1					V
NME3					V
RRM2					V
MPO					V					V
MGST1					V
GSTO1					V
DPYS							V	V
UGT1A6							V
ITPA										V
XDH										V
DPYD										V
UMPS										V
IMPDH1										V
IMPDH2										V
CYP3A4										V
CYP2A6										V
CYP2E1										V		V
NAT2												V
+ 2. Genetic Information Processing	3.4	12.9	3.3	13.3	2.5	4	0.1	0.3	0.5	2	2.9	0
+ 2.1 Transcription	0.3	8.5	0.3	8	0.3	0.1	0	0	0	0	0	0
+ 03020: RNA polymerase	0	4.4	0	4.1	0	0	0	0	0	0	0	0
POLR2A		V		V
POLR2E		V		V
POLR2H		V		V
POLR2I		V		V
POLR2J		V		V
POLR2K		V		V
POLR1D		V		V
POLR3GL		V		V
POLR1E		V		V
+ 03022: Basal transcription factors	0	2.3	0	2	0	0	0	0	0	0	0	0
TAF6		V		V
TAF7		V		V
GTF2B		V		V
TAF12		V		V
TAF13		V		V
TAF15		V		V
+ 03040: Spliceosome	0.4	8	0.5	7.7	0.5	0.2	0	0	0	0	0	0
SRSF2	V		V	V
DDX46		V		V
SNRPA		V		V
SNRPC		V		V
SNRPD1		V		V
SNRPF		V		V
TCERG1		V		V
SF3A2		V		V
SF3B6		V		V
SF3B5		V		V
PUF60		V		V
SMNDC1		V		V
CHERP		V		V
RBMX		V		V
HNRNPC		V		V		V
HNRNPU		V		V
SRSF8		V		V
SRSF3		V		V
SRSF6		V		V
PRPF19		V		V
CWC15		V		V
SYF2		V		V
WBP11		V		V
CCDC12		V		V
LSM4		V		V
LSM3		V		V
PRPF4		V		V
SNU13		V		V
SNRNP27		V		V
SART1		V		V
MAGOH		V		V
ALYREF		V		V
SLU7		V		V
PRPF38A		V		V
BUD31		V		V
DHX15					V
HSPA1B					V
HSPA6					V
+ 2.2 Translation	2	7.4	2.1	7.5	0.5	1.8	0	0	0	0.1	0.4	0
+ 03010: Ribosome	1	3.6	1.1	3.7	0	0.2	0	0	0	0	0	0
MRPL23	V		V	V
MRPL27	V		V	V
RPL28		V		V
RPS27L		V		V
RPL27A		V		V
RSL24D1		V		V
RPL36AL		V		V
RPL34		V		V
RPL29		V		V
RPL38		V		V
MRPL16		V		V
MRPL21		V		V
MRPS5		V		V
MRPS9		V		V
MRPS12		V		V
MRPS15		V		V
MRPS6		V		V
MRPS21		V		V
MRPL1		V		V
RPS7						V
+ 00970: Aminoacyl-tRNA biosynthesis	2.8	0.9	2.8	2.1	0.5	0	0	0	0	0.3	0.8	0
KARS	V		V	V
WARS	V		V	V						V	V
YARS	V		V	V
IARS2		V		V
CARS		V		V
GATB		V		V
RARS					V
+ 03013: RNA transport	0	4.6	0	4.1	0.3	0.8	0	0	0	0	0	0
PHAX		V		V
CLNS1A		V		V
MAGOH		V		V
RNPS1		V		V
SAP18		V		V
SRRM1		V		V
NXF1		V		V
ALYREF		V		V
NUP62		V		V	V
UBE2I		V		V
SUMO3		V		V
SUMO1		V		V
UPF1		V		V
EIF3B		V		V
EIF3H		V		V
POP7		V		V
RPP25L		V		V
THOC6		V		V
THOC7		V		V
EIF4G1		V		V
UPF3B		V		V
EIF4EBP2		V		V
EIF2B2		V		V
SNUPN					V
TACC3					V
PABPC1						V
PABPC4						V
FMR1						V
+ 03015: mRNA surveillance pathway	0.6	4.2	0.7	4.1	0.1	3	0	0	0	0	0	0
PPP2CB	V		V	V
MAGOH		V		V
RNPS1		V		V
SAP18		V		V
SRRM1		V		V
NXF1		V		V
ALYREF		V		V
UPF3B		V		V
UPF1		V		V
GSPT2		V		V
GSPT1		V		V
NUDT21		V		V
CPSF4		V		V
CSTF1		V		V
PPP1CC		V		V
SSU72		V		V
PPP2R1A					V
PABPC1						V
PABPC4						V
PPP2R5A						V
MSI2						V
DAZAP1						V
MSI1						V
+ 03008: Ribosome biogenesis in eukaryotes	0	3.2	0	2.8	0.2	0	0	0	0	0	0	0
SNU13		V		V
DKC1		V		V
NAT10		V		V
UTP14A		V		V
POP7		V		V
RPP25L		V		V
GNL3		V		V
NXF1		V		V
MPHOSPH10		V		V
IMP3		V		V
CSNK2A3		V		V
GNL3L					V
+ 2.3 Folding, sorting and degradation	4.5	4.5	4.2	6.2	3.5	5.7	0	0.2	0.6	1.1	1.3	0
+ 03060: Protein export	0	2.8	0	2.6	0	0	0	0	0	1.4	2.1	0
SRP14		V		V
SRP19		V		V
SRP9		V		V
SEC62		V		V
SPCS1		V		V
OXA1L										V	V
IMMP2L										V	V
+ 04141: Protein processing in endoplasmic reticulum	2.6	1.4	2.1	2.3	2.8	0.8	0	0.4	0	0	0.2	0
CALR	V			V
SYVN1	V		V	V
XBP1	V		V	V
PDIA6	V		V	V
CKAP4	V		V	V
ATF4		V		V
CANX		V		V
SEC62		V		V
EIF2AK1		V		V
ERLEC1		V		V
DNAJB2		V		V
STUB1		V		V
ERP29		V		V
UBXN6		V		V
NFE2L2		V		V
BCAP31		V		V
MAP3K5					V
LMAN1					V
BAK1					V
HSPA1B					V
HSPA6					V
OS9					V
FBXO6					V
SKP1					V
TRAM1					V
SIL1					V
CAPN2						V
UBE2G2						V
CRYAB						V
TUSC3								V
MAN1C1								V
VCP										V	V
+ 04130: SNARE interactions in vesicular transport	1.2	2.3	1.2	2.5	1.3	0	0	0	0.9	0	0	0
VAMP5	V		V	V
BET1L		V		V
GOSR1		V		V
STX16		V		V
VAMP4		V		V
SNAP23		V		V
STX11					V
STX8					V
STX1A									V
+ 04120: Ubiquitin mediated proteolysis	2.8	0.9	2.9	2	1.2	2.4	0.1	0.2	0	0	0.2	0
SOCS1	V		V	V
SYVN1	V		V	V
PML	V		V	V
UBE2L6	V		V	V
UBE2H	V		V	V
SAE1		V		V
UBE2F		V		V
DDB1		V		V
PRPF19		V		V
UBE2N		V		V
UBE2R2		V		V
STUB1		V		V
UBE2I		V		V
SOCS3					V
UBA3					V
SKP1					V
UBE4A					V
UBE2Q1					V
UBE2K						V
UBE2G2						V
CDC34						V
WWP2						V
NEDD4L						V
NEDD4						V
UBOX5							V
SMURF1								V
RNF7										V	V
+ 04122: Sulfur relay system	0	1.9	0	1.8	1.4	0	0	0	0	0	0	0
CTU2		V		V
CTU1		V		V
NFS1					V
+ 03050: Proteasome	5.4	0.9	4.9	3.7	2.3	8.7	0	0	0.7	0.3	0.8	0
PSMD4	V		V	V		V
PSME2	V			V
PSMA6	V		V	V	V
PSMA4	V		V	V
PSMB6	V		V	V
PSMB3	V		V	V
POMP	V		V	V
IFNG		V		V					V	V	V
PSMD7		V		V
PSMC3		V		V		V
PSMC4					V	V
PSMA3					V
PSMB5					V
PSMD3						V
PSMD12						V
PSMD11						V
PSMD6						V
PSMD13						V
PSMD14						V
PSMD8						V
PSMD2						V
PSMD1						V
PSMC2						V
PSMC1						V
PSMC6						V
PSMC5						V
+ 03018: RNA degradation	0	1.7	0	1.4	0.2	3.3	0	0	0	1.3	0	0
PNPT1		V		V		V
EXOSC5		V		V
MPHOSPH6		V		V
CNOT3		V		V
LSM1		V		V
LSM3		V		V
LSM4		V		V
NUDT16					V
ENO1						V
PATL1						V
HSPD1						V
PABPC1						V
PABPC4						V
ENO2										V
ENO4										V
PFKL										V
PFKM										V
+ 2.4 Replication and repair	0	5.4	0	4.9	0.6	0.3	0.2	0.3	0.3	2.7	4.1	0
+ 03030: DNA replication	0	3.1	0	2.9	0.6	0	0	0	0	0.4	0.9	0
RNASEH2A		V		V
RFC2		V		V
POLD4		V		V
POLE3		V		V
SSBP1		V		V
POLD2		V		V
RPA1		V		V
POLA2					V
LIG1										V	V
+ 03410: Base excision repair	0	2.3	0	2.1	0	0.8	0	0	0.9	4.6	5.8	0
APEX1		V		V
PARP1		V		V						V	V
POLE3		V		V
POLD2		V		V
POLD4		V		V
HMGB1						V			V
PARP2										V	V
PARP3										V	V
PARP4										V	V
LIG1										V	V
LIG3										V	V
XRCC1										V	V
OGG1										V	V
+ 03420: Nucleotide excision repair	0	3.1	0	2.8	0	0	0	0	0	0.3	0.8	0
DDB1		V		V
RFC2		V		V
POLE3		V		V
POLD2		V		V
POLD4		V		V
RPA1		V		V
ERCC1		V		V
CETN2		V		V
LIG1										V	V
+ 03430: Mismatch repair	0	2.8	0	2.6	0	0	0	0	0	0.7	1.2	0
POLD2		V		V
POLD4		V		V
RPA1		V		V
RFC2		V		V
SSBP1		V		V
LIG1										V	V
+ 03440: Homologous recombination	0	2	0	1.7	0	0	0.6	0.8	0	0	0	0
RPA1		V		V
POLD2		V		V
POLD4		V		V
SSBP1		V		V
BABAM1		V		V
XRCC2							V	V
+ 03450: Non-homologous end-joining	0	0.7	0	0.6	0	0	0	0	0	1	1.4	0
XRCC5		V		V
LIG4										V	V
+ 03460: Fanconi anemia pathway	0	0.3	0	0.2	0.9	0	0	0	0	0.2	0.7	0
RPA1		V		V
ERCC1		V		V
RMI2					V
SLX1B					V
USP1										V	V
+ 3. Environmental Information Processing	2.5	1.3	2.3	1.4	2.8	7.8	5.1	5.3	21.1	6.6	7.9	1.1
+ 3.1 Membrane transport	0	0	0	0	0	0	0.5	1.5	0	0.8	1.6	0
+ 02010: ABC transporters	0	0	0	0	0	0	0.5	1.5	0	0.8	1.6	0
ABCC12							V
ABCC4								V		V	V
ABCC9								V
ABCB11										V	V
+ 3.2 Signal transduction	3.2	2.1	2.9	2.3	3.3	7	4.6	4	13.9	10.5	10.6	1.9
+ 04010: MAPK signaling pathway	0.1	1.1	0.1	0.6	0.9	2.1	1.7	0.8	5.6	1.1	3.3	0
MAX	V	V	V	V
DUSP7		V		V
PRKCB		V		V
MAPKAPK2		V		V
ATF4		V		V
PPP5C		V		V
TAOK3		V		V
MAP3K13		V		V
TAB1		V		V
DAXX		V		V
TGFBR1		V		V
MAPKAPK5		V		V
RAC2		V		V						V	V
CDC42		V		V
NFATC1		V		V
MYC		V		V
FLT3LG		V		V					V
NFKB2					V
NLK					V
MAP3K5					V
PAK1					V
MAP2K4					V
HSPA1B					V
HSPA6					V
MKNK2					V
MAPT						V
CACNA1D						V
MEF2C						V
TAOK1						V
JUN						V
EFNA5						V	V	V
FGF3						V
FGF8						V
HGF						V	V
RASGRF1							V
ERBB3							V
FGFR1							V
KDR							V	V
PDGFRA							V
CACNG2							V
EREG							V	V	V
ANGPT1							V		V
FGFR2								V
FGF18								V
FASLG									V
EGFR									V
IL1R1									V
IL1RAP									V
TNFRSF1A									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
IL1A									V
IL1B									V	V	V
TNF									V	V	V
CSF1									V
FGF2									V
INS									V	V	V
KITLG									V
VEGFA									V
NFKB1										V	V
INSR										V	V
TP53										V	V
ECSIT										V	V
RAC1										V	V
PDGFB										V	V
+ 04012: ErbB signaling pathway	0	0.3	0	0.2	1	0.9	2.1	0.4	1.6	0.3	0.4	0
PRKCB		V		V
CAMK2G		V		V
MYC		V		V
STAT5A					V
PAK1					V
MAP2K4					V
GSK3B						V
JUN						V
ERBB3							V
GAB1							V
NRG2							V
SHC4							V
EREG							V	V	V
EGFR									V
NRG1									V
ABL1										V	V
PIK3CD										V
+ 04014: Ras signaling pathway	0	0.2	0	0.1	0.1	1.9	2.3	2	3.3	0.8	2.2	0
FLT3LG		V		V					V
RAC2		V		V						V	V
PRKCB		V		V
RALBP1		V		V
CDC42		V		V
PLA2G12A		V		V
RASSF5		V		V
CALM2		V		V
LAT		V		V
GNG10					V
PAK1					V
REL					V
EFNA5						V	V	V
FGF3						V
FGF8						V
HGF						V	V
RHOA						V
RASSF1						V
ZAP70						V
SHC4							V
ANGPT1							V		V
FGFR1							V
KDR							V	V
PDGFRA							V
GAB1							V
FOXO4							V
RASGRF1							V
FGF18								V
FGFR2								V
PLCE1								V
PLA2G2F								V
GNG3								V
CSF1									V
FGF2									V
INS									V	V	V
KITLG									V
VEGFA									V
EGFR									V
FASLG									V
PLA2G5									V
PIK3CD										V
PDGFB										V	V
INSR										V	V
RAC1										V	V
ABL1										V	V
NFKB1										V	V
+ 04015: Rap1 signaling pathway	0.2	0.4	0.2	0.3	0	1.2	1.8	1.3	2.7	1	2.4	0
ACTB	V		V	V
RAC2		V		V						V	V
RASSF5		V		V
ITGB1		V		V
F2R		V		V
CDC42		V		V
CALM2		V		V
PRKCB		V		V
LAT		V		V
PARD6A		V		V
PRKD2					V
EFNA5						V	V	V
FGF3						V
FGF8						V
HGF						V	V
RHOA						V
ANGPT1							V		V
FGFR1							V
KDR							V	V
PDGFRA							V
ADCY2							V
ADCY5							V
FGF18								V
FGFR2								V
PLCE1								V
CSF1									V
FGF2									V
INS									V	V	V
KITLG									V
VEGFA									V
EGFR									V
THBS1									V
PDGFB										V	V
INSR										V	V
RAC1										V	V
GNAI2										V	V
GNAI3										V	V
PIK3CD										V
+ 04310: Wnt signaling pathway	0	1.1	0	0.8	0.6	1.7	0.5	0.1	2.3	0.6	2	0
NFATC1		V		V
PRKCB		V		V
CAMK2G		V		V
RAC2		V		V						V	V
CCND3		V		V
MYC		V		V
LEF1		V		V
RUVBL1		V		V
CTNNBIP1		V		V
CSNK2A3		V		V
FZD2					V
NLK					V
SKP1					V
FRAT2					V
WNT5A						V			V
RHOA						V
JUN						V
GSK3B						V
WNT3A						V			V
APC							V
CER1							V		V
ZNRF3							V
DKK4								V
WNT1									V
WNT2									V
WNT7A									V
RAC1										V	V
CTBP1										V	V
CTBP2										V	V
TP53										V	V
+ 04330: Notch signaling pathway	1	0.4	1	0.6	1	0.6	0	0	0	3.4	4.8	0
DTX3L	V		V	V						V	V
HDAC1		V		V						V	V
HDAC2		V		V						V	V
PSEN2					V
KAT2B					V					V	V
ADAM17						V
CTBP1										V	V
CTBP2										V	V
KAT2A										V	V
+ 04340: Hedgehog signaling pathway	0	0	0	0	0	0.7	0.5	0.7	0	0	0	0
GSK3B						V
GLI3							V
SMURF1								V
+ 04350: TGF-beta signaling pathway	1.3	0.4	1.4	0.8	0.4	0.8	0	0.3	6.3	1	2.2	0
PPP2CB	V		V	V
BMP6	V		V	V
MYC		V		V
TGFBR1		V		V
IFNG		V		V					V	V	V
TGIF2		V		V
PPP2R1A					V
SKP1					V
SP1						V
RHOA						V
SMURF1								V
THBS1									V
INHBA									V
INHBB									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
TNF									V	V	V
BMP4									V
NOG									V
CHRD									V
GREM1									V
GREM2									V
BMP2										V	V
+ 04390: Hippo signaling pathway	2.6	1.2	2.7	1.9	0.4	2.2	0.1	0.5	3.7	0.1	0.6	0
YWHAH	V		V	V
YWHAZ	V	V	V	V
ACTB	V		V	V
BMP6	V		V	V
PPP2CB	V		V	V
NF2		V		V
SAV1		V		V
PPP1CC		V		V
YWHAQ		V		V
PARD6A		V		V
TGFBR1		V		V
LEF1		V		V
MYC		V		V
CCND3		V		V
YWHAE					V	V
FZD2					V
PPP2R1A					V
RASSF1						V
MOB1B						V
WNT5A						V			V
WNT3A						V			V
GSK3B						V
APC							V
AMOT								V
SERPINE1								V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
WNT1									V
WNT2									V
WNT7A									V
BMP4									V
BMP2										V	V
+ 04392: Hippo signaling pathway - multiple species	0	0.8	0	0.7	0.7	1.8	0	0	0	0	0	0
NF2		V		V
SAV1		V		V
PAK1					V
MOB1B						V
RASSF1						V
+ 04370: VEGF signaling pathway	0	1.4	0	1.2	0	0	0.4	0.6	0.6	3.1	1.4	0
CDC42		V		V
MAPKAPK2		V		V
PRKCB		V		V
PXN		V		V
RAC2		V		V						V	V
KDR							V	V
VEGFA									V
SPHK2										V
SPHK1										V
PTGS2										V
PIK3CD										V
NOS3										V
RAC1										V	V
+ 04371: Apelin signaling pathway	1	0.2	0.4	0.4	0.2	0.9	1	2.5	0.2	4.6	4.5	0
PRKAG2	V			V
GABARAP	V		V	V
PIK3R5		V		V
TGFBR1		V		V
GABARAPL2		V		V
BECN1		V		V
CALM2		V		V
GNG10					V
PIK3R6					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
MEF2C						V
PRKAB2							V	V
MYLK3							V
ADCY2							V
ADCY5							V
SERPINE1								V
GNG3								V
RYR2								V		V	V
UCP1								V
SPP1									V
PRKAG3										V	V
SPHK2										V
SPHK1										V
GNAI2										V	V
GNAI3										V	V
PIK3CG										V
PPARGC1A										V	V
NOS1										V
NOS2										V
NOS3										V
HDAC5										V	V
HDAC4										V	V
AGTR1										V	V
+ 04064: NF-kappa B signaling pathway	0.6	0.9	0.6	0.9	1.7	3.8	0.2	0	6.5	1.3	2.1	2.9
CD40	V		V	V
PRKCB		V		V
TAB1		V		V
LAT		V		V
CSNK2A3		V		V
PARP1		V		V						V	V
UBE2I		V		V
NFKB2					V
TNFSF13B					V				V
BCL2A1					V
BTK					V
ICAM1					V
TNFSF14						V			V
CD40LG						V			V
TLR4						V						V
ZAP70						V
SYK						V
CCL4						V			V
CCL21						V
CYLD						V
TNFRSF11A							V
IL1R1									V
TNFRSF1A									V
IL1B									V	V	V
TNF									V	V	V
CXCL8									V
TNFSF11									V
LBP									V
CXCL2									V
CCL19									V
LTA									V
NFKB1										V	V
PTGS2										V
TIRAP												V
+ 04668: TNF signaling pathway	0.5	0.3	0.6	0.3	2.4	2.7	0.4	0.3	8.8	1.2	1.4	1.7
CEBPB	V		V	V
ATF4		V		V
CCL5		V		V		V			V
JUNB		V		V
TAB1		V		V
MAP2K4					V
CASP7					V
CXCL10					V	V	V		V
BCL3					V
SOCS3					V
ICAM1					V
MAP3K5					V
JUN						V
NOD2						V
IRF1						V
IFNB1						V			V
CCL2							V		V
MMP3								V	V
TNF									V	V	V
TNFRSF1A									V
CCL20									V
CXCL1									V
CXCL2									V
CX3CL1									V
CSF1									V
CSF2									V
IL1B									V	V	V
IL6									V
IL15									V
LIF									V
LTA									V
MMP9									V			V
EDN1									V
TNFRSF1B									V
NFKB1										V	V
PTGS2										V
PIK3CD										V
+ 04066: HIF-1 signaling pathway	1.3	0.5	1.3	0.9	1.6	1.3	0.1	0.8	4.8	7.8	2.6	2.9
GAPDH	V		V	V						V
TIMP1	V		V	V					V			V
PRKCB		V		V
CAMK2G		V		V
ALDOA		V		V		V				V
HMOX1		V		V						V
IFNG		V		V					V	V	V
CYBB					V					V	V
HK1					V
HK3					V
PGK1					V					V
MKNK2					V
ENO1						V
TLR4						V						V
ANGPT1							V		V
TF								V
SERPINE1								V
VEGFA									V
INS									V	V	V
EGFR									V
EPO									V
EDN1									V
IL6									V
IL6R									V
INSR										V	V
PIK3CD										V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
PDHA1										V
PDHA2										V
PDHB										V
HK2										V
PFKL										V
ENO2										V
ENO4										V
NOS2										V
NOS3										V
NFKB1										V	V
+ 04068: FoxO signaling pathway	1.1	0.3	0.5	0.5	1.3	0.5	0.3	0.6	4.4	2.3	3.2	0
PRKAG2	V			V
GABARAP	V		V	V
HOMER2		V		V
BNIP3		V		V
GABARAPL2		V		V
TGFBR1		V		V
USP7		V		V
PCK2					V
TNFSF10					V				V
CAT					V					V
SGK1					V
NLK					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
PRKAB2							V	V
FOXO4							V
INS									V	V	V
EGFR									V
FASLG									V
IL7R									V
IL6									V
IL10									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
PRKAG3										V	V
INSR										V	V
PIK3CD										V
SIRT1										V	V
+ 04020: Calcium signaling pathway	0.3	0.3	0.3	0.3	0.1	1.8	1.2	1	0.1	2.4	2.1	0
TBXA2R	V		V	V
CAMK2G		V		V
PRKCB		V		V
F2R		V		V
CALM2		V		V
SLC25A5		V		V
SLC25A6		V		V
ATP2A3		V		V
STIM1		V		V
VDAC3					V
CD38					V					V
CHRNA7						V
P2RX2						V
P2RX3						V
P2RX4						V
P2RX5						V
CACNA1D						V
ERBB3							V
PDGFRA							V
MYLK3							V
PTGER3							V	V
ADCY2							V
ATP2B2							V
PLCE1								V
P2RX6								V
RYR2								V		V	V
EGFR									V
NOS1										V
NOS2										V
NOS3										V
CAMK1D										V	V
P2RX7										V	V
SPHK2										V
SPHK1										V
AGTR1										V	V
TRHR										V	V
DRD5										V	V
+ 04070: Phosphatidylinositol signaling system	0	0.2	0	0.1	0	0	0.5	0.8	0	3.7	0	0
CALM2		V		V
CDIPT		V		V
PRKCB		V		V
PIP5K1A							V	V
PIK3C2G							V
PLCE1								V
PIK3CD										V
DGKK										V
DGKA										V
DGKB										V
DGKG										V
DGKH										V
DGKQ										V
DGKZ										V
DGKE										V
DGKD										V
DGKI										V
+ 04072: Phospholipase D signaling pathway	0.4	0	0.4	0	0.2	0.9	1.7	0.2	2.4	5.3	2.1	0
FCER1G	V		V	V		V
F2R		V		V
PIK3R5		V		V
PIK3R6					V
ARF1					V
RHOA						V
SYK						V
SHC4							V
PDGFRA							V
GAB1							V
PIP5K1A							V	V
ADCY2							V
ADCY5							V
KITLG									V
EGFR									V
INS									V	V	V
CXCL8									V
F2									V
AGT									V	V	V
PIK3CD										V
INSR										V	V
AGTR1										V	V
PIK3CG										V
DGKK										V
DGKA										V
DGKB										V
DGKG										V
DGKH										V
DGKQ										V
DGKZ										V
DGKE										V
DGKD										V
DGKI										V
SPHK2										V
SPHK1										V
PDGFB										V	V
+ 04071: Sphingolipid signaling pathway	1.1	0	1.2	0.1	1.4	1.1	0	0	1.2	3.6	3.4	0
PPP2CB	V		V	V
FCER1G	V		V	V		V
PRKCB		V		V
RAC2		V		V						V	V
SPTLC2					V
CTSD					V
MAP3K5					V
PPP2R1A					V
BID					V
RHOA						V
PPP2R5A						V
TNF									V	V	V
ASAH2									V
TNFRSF1A									V
PIK3CD										V
GNAI2										V	V
GNAI3										V	V
SPHK2										V
SPHK1										V
SMPD1										V
TP53										V	V
NOS3										V
NFKB1										V	V
RAC1										V	V
+ 04024: cAMP signaling pathway	0.2	0.1	0.2	0.1	0.1	0.5	2.5	1.7	1	1.6	3.2	0
MYL9	V		V	V
ATP2A3		V		V
CALM2		V		V
CAMK2G		V		V
NFATC1		V		V
PPP1CC		V		V
F2R		V		V
RAC2		V		V						V	V
ATP1B2					V
ACOX1					V
PAK1					V
CACNA1D						V
RHOA						V
JUN						V
ATP1B4							V
PTGER3							V	V
GABBR2							V
ADCY2							V
ADCY5							V
ATP2B2							V
CNGA1							V
PDE4A							V
GLI3							V
TSHB							V
RYR2								V		V	V
NPY1R								V
PLCE1								V
CNGB3								V
ABCC4								V		V	V
GHRL									V
POMC									V
EDN1									V
EDN2									V
GNAI2										V	V
GNAI3										V	V
PIK3CD										V
DRD5										V	V
TSHR										V	V
NFKB1										V	V
RAC1										V	V
+ 04022: cGMP-PKG signaling pathway	0.3	0.5	0.4	0.5	0.6	0.7	3.4	0.8	0.1	1.2	1.9	0
MYL9	V		V	V
PPP1CC		V		V
NFATC1		V		V
ATP2A3		V		V
ATF4		V		V
PIK3R5		V		V
SLC25A5		V		V
SLC25A6		V		V
CALM2		V		V
KCNMB1					V
ATP1B2					V
PIK3R6					V
VDAC3					V
CACNA1D						V
RHOA						V
MEF2C						V
PRKG2							V
KCNMB2							V	V
KCNMB4							V
KCNMA1							V
CNGA1							V
ATP1B4							V
ATP2B2							V
MYH6							V	V
ADCY2							V
ADCY5							V
MYLK3							V
GATA4								V
INS									V	V	V
AGTR1										V	V
PIK3CG										V
NOS3										V
INSR										V	V
GNAI2										V	V
GNAI3										V	V
+ 04151: PI3K-Akt signaling pathway	1	0	1.1	0	0.5	3	2.4	3.1	9.3	0.7	1.8	2.1
YWHAH	V		V	V
YWHAZ	V	V	V	V
PPP2CB	V		V	V
ITGB7	V		V	V
F2R		V		V
MYC		V		V
YWHAQ		V		V
FLT3LG		V		V					V
PIK3R5		V		V
ITGB1		V		V
ATF4		V		V
CCND3		V		V
PCK2					V
YWHAE					V	V
PPP2R1A					V
PIK3R6					V
GNG10					V
CSF3R					V				V
EPOR					V
SGK1					V
GSK3B						V
EFNA5						V	V	V
FGF3						V
FGF8						V
HGF						V	V
PPP2R5A						V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
SYK						V
TLR2						V						V
TLR4						V						V
IFNB1						V			V
ERBB3							V
FGFR1							V
KDR							V	V
PDGFRA							V
EREG							V	V	V
ANGPT1							V		V
ITGA9							V	V
LAMB4							V
THBS2							V
VWF							V
GHR							V	V	V
IFNA10							V	V
FGFR2								V
FGF18								V
GNG3								V
COL4A5								V
COL6A6								V
TNN								V
EGFR									V
FASLG									V
CSF1									V
FGF2									V
INS									V	V	V
KITLG									V
VEGFA									V
COL1A2									V
FN1									V
LAMA5									V
SPP1									V
THBS1									V
IL4R									V
IL6R									V
IL7R									V
PRLR									V
CSF3									V
EPO									V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
IL2									V
IL3									V
IL4									V
IL6									V
IL7									V
OSM									V
PIK3CD										V
INSR										V	V
TP53										V	V
NFKB1										V	V
PDGFB										V	V
NOS3										V
PIK3CG										V
RAC1										V	V
+ 04152: AMPK signaling pathway	1.8	0	1.2	0.1	1	1.6	0.1	1.2	1.2	4.3	3.4	0
PRKAG2	V			V
PPP2CB	V		V	V
RAB8A	V		V	V
RAB11B		V		V
FBP1					V
PCK2					V
TBC1D1					V
PPP2R1A					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
EEF2K						V		V
PPP2R5A						V
PRKAB2							V	V
INS									V	V	V
ADIPOQ									V
LEP									V
PRKAG3										V	V
INSR										V	V
PIK3CD										V
SIRT1										V	V
PPARGC1A										V	V
PFKFB1										V
PFKFB2										V
PFKL										V
PFKM										V
FASN										V
HMGCR										V
+ 04150: mTOR signaling pathway	0.9	0	1	0	0.4	2.2	0	0.1	3.3	1	2	0
LAMTOR5	V		V	V
LAMTOR2	V		V	V
PRKCB		V		V
ATP6V1G1		V		V
SGK1					V
ATP6V1E1					V
FZD2					V
RHOA						V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
GSK3B						V
WNT5A						V			V
WNT3A						V			V
TNF									V	V	V
TNFRSF1A									V
INS									V	V	V
WNT1									V
WNT2									V
WNT7A									V
INSR										V	V
PIK3CD										V
+ 3.3 Signaling molecules and interaction	1.1	0.1	1.1	0.1	1.6	6.5	3.7	3.6	22.7	0.1	1.5	0
+ 04080: Neuroactive ligand-receptor interaction	0.1	0	0.1	0	0	3.4	1.9	2.3	2.1	0.1	1.2	0
TBXA2R	V		V	V
F2R		V		V
TSPO					V
GPR35					V
C3AR1					V
ADM					V
P2RX2						V
P2RX3						V
P2RX4						V
P2RX5						V
CHRNA1						V		V
CHRNA2						V
CHRNA3						V
CHRNA4						V
CHRNA5						V
CHRNA7						V
CHRNB1						V
CHRNB2						V
CHRNB4						V
C3						V
TSHB							V
GHR							V	V	V
GRID1							V
GABRA4							V
GABRA6							V
GABRG2							V
GABBR2							V
MTNR1B							V
PTGER3							V	V
NMBR							V
AGTR2							V
TAC1							V
P2RX6								V
GABRA5								V
PTH2R								V
NPFFR2								V
OPRK1								V
NPY1R								V
TAAR9								V
F2									V
PRLR									V
LEP									V
AGT									V	V	V
EDN1									V
EDN2									V
GHRL									V
POMC									V
P2RX7										V	V
TRHR										V	V
TSHR										V	V
AGTR1										V	V
DRD5										V	V
+ 04060: Cytokine-cytokine receptor interaction	0.8	0	0.8	0.1	2	4.7	2.3	1.5	26.7	0.1	1.4	0
IL10RB	V		V	V
CD40	V		V	V
BMP6	V		V	V
TGFBR1		V		V
TNFRSF4		V		V
CD27		V		V
CD70		V		V
IFNG		V		V					V	V	V
TNFSF12		V		V
CCL5		V		V		V			V
IL32		V		V					V
TNFSF13B					V				V
EPOR					V
IL15RA					V				V
IL12RB1					V
CSF3R					V				V
CXCL10					V	V	V		V
PPBP					V
TNFSF10					V				V
CCR1					V
IL27					V				V
IL31RA					V
IL1RN					V				V
IL20RB						V
TNFSF4						V
CD40LG						V			V
TNFSF14						V			V
IFNB1						V			V
TSLP						V			V
IL23A						V			V
IL12B						V	V		V
XCL1						V			V
CXCL13						V
CCL4						V			V
CCL3						V			V
CCL21						V
CCR2						V
CD4						V
IFNE							V
IFNK							V		V
IFNA10							V	V
GHR							V	V	V
CXCL11							V	V
TNFRSF11A							V
CCL2							V		V
CCL18							V	V
GDF3							V
BMP3							V
IL20								V	V
IL9								V
IL36RN								V	V
IL4									V
LIFR									V
IL6ST									V
IL1R2									V
IL1RAP									V
IL1R1									V
IL17RA									V
IL18									V
IL1B									V	V	V
IL1A									V
IL25									V
IL17B									V
IL17A									V
INHBB									V
INHBA									V
TGFB3									V
TGFB2									V
TGFB1									V	V	V
TNFRSF18									V
TNFSF13									V
FASLG									V
LTA									V
IL26									V
IFNL1									V
IFNL2									V
IFNL3									V
IL22									V
IL24									V
IL19									V
IL10									V
IFNW1									V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
PRLR									V
CRLF2									V
IL7R									V
IL4R									V
CSF2RA									V
THPO									V
EPO									V
IL21									V
IL15									V
IL7									V
IL2									V
IL5									V
IL3									V
CSF2									V
IL6R									V
IL12A									V
IL13									V	V	V
CSF3									V
CTF1									V
CLCF1									V
LIF									V
OSM									V
IL11									V
IL6									V
CX3CL1									V
PF4									V
CXCL16									V
CXCL9									V
CXCL8									V
CXCL6									V
TNFRSF1A									V
TNFRSF1B									V
TNFRSF11B									V
TNFSF15									V
TNF									V	V	V
CXCL1									V
CXCL2									V
TNFSF11									V
IL17RB									V
IL17F									V
IL17C									V
IL17D									V
CCL19									V
CCL11									V
CCL22									V
CCL20									V
IL31									V
IL36A									V
IL37									V
IL36B									V
IL36G									V
IL1F10									V
IL33									V
IL1RL1									V
IL16									V
IL34									V
CSF1									V
TNFRSF25									V
INHA									V
BMP4									V
LEP									V
BMP2										V	V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	0.6	0	0.6	0	1.2	4.7	1.4	1.4	13.3	0.1	0.4	0
IL10RB	V		V	V
CCL5		V		V		V			V
CCR1					V
PPBP					V
CXCL10					V	V	V		V
TNFSF10					V				V
CCL3						V			V
CCR2						V
CCL4						V			V
CCL21						V
CXCL13						V
XCL1						V			V
IL20RB						V
TNFSF14						V			V
CCL2							V		V
CCL18							V	V
CXCL11							V	V
IL20								V	V
CCL11									V
CCL22									V
CCL20									V
CCL19									V
CX3CL1									V
CXCL1									V
CXCL2									V
CXCL8									V
CXCL6									V
CXCL9									V
PF4									V
IL10									V
IL6ST									V
IL6R									V
IL6									V
IL2									V
IL37									V
IL18									V
IL24									V
IL19									V
IL34									V
CSF1									V
LTA									V
TNFRSF1A									V
TNFRSF1B									V
TNF									V	V	V
+ 04512: ECM-receptor interaction	0.7	0.1	0.7	0.2	0	0.3	1.6	2.1	3.3	0	0	0
ITGB7	V		V	V
ITGB1		V		V
CD44		V		V
DAG1						V
LAMB4							V
VWF							V
THBS2							V
ITGA9							V	V
COL4A5								V
COL6A6								V
TNN								V
LAMA5									V
COL1A2									V
SPP1									V
FN1									V
THBS1									V
SDC1									V
+ 4. Cellular Processes	5.8	4.6	5.8	6	4.3	4.2	3	2.3	5.7	4.3	6.7	1.1
+ 4.1 Transport and catabolism	4.9	2.8	4.9	4.2	4	2.9	0.3	0.5	1.2	3.2	3.3	1.7
+ 04144: Endocytosis	2	2.4	2.1	2.9	1.2	0.7	0.1	0.4	0.5	0	0	0
AP2S1	V		V	V
CHMP2A	V		V	V
PML	V		V	V
CAPZA2	V		V	V
RAB8A	V		V	V
AP2A2		V		V
VPS37C		V		V
VPS36		V		V
TSG101		V		V
SNF8		V		V
CHMP4A		V		V
CDC42		V		V
PARD6A		V		V
RAB11B		V		V
SH3GLB1		V		V
EEA1		V		V
ACAP3		V		V
AGAP3		V		V
ARFGAP3		V		V
ARFGAP1		V		V
TGFBR1		V		V
ARPC2		V		V
ARPC5L		V		V
SNX3		V		V
WIPF1		V		V
HSPA1B					V
HSPA6					V
CHMP1A					V
IQSEC2					V
ARF1					V
RAB35					V
VPS26A					V
RAB31					V
NEDD4L						V
NEDD4						V
GBF1						V
RHOA						V
CLTB							V
PDGFRA							V
PIP5K1A							V	V
SMURF1								V
FGFR2								V
EGFR									V
HLA-E									V
HLA-G									V
+ 04145: Phagosome	3.7	0.2	3.3	1.4	1.8	2.2	0.2	0.1	1.9	1.7	2.5	4.5
ACTB	V		V	V
CYBA	V		V	V						V	V
NCF4	V		V	V						V	V
TUBA1C	V		V	V
TUBB4B	V		V	V
ATP6V0E1	V		V	V
CALR	V			V
ITGB1		V		V
EEA1		V		V
TUBA8		V		V
ATP6V1G1		V		V
CANX		V		V
FCGR1A					V
CYBB					V					V	V
TUBB					V
ATP6V1E1					V
MPO					V					V
STX12					V
CTSL					V
C1R						V
TLR2						V						V
TLR4						V						V
C3						V
MBL2						V
COLEC11						V
THBS2							V
SFTPA2							V	V
PLA2R1									V
THBS1									V
SFTPD									V
HLA-E									V
HLA-G									V
NCF1										V	V
NCF2										V	V
RAC1										V	V
NOS1										V
MRC1												V
CD209												V
+ 04142: Lysosome	1.1	0.1	1.2	0.2	4.1	0	0.3	0.2	0	0.3	0.8	0
CTSA	V		V	V
AP1S1	V		V	V
DNASE2		V		V
AP3S2		V		V
LITAF		V		V	V
CTSB					V
CTSD					V
CTSL					V
GAA					V
GBA					V
GNS					V
GM2A					V
PSAP					V
PPT1					V
CD63					V
NPC2					V
LAMP3							V
CLTB							V
CTSV								V
SMPD1										V
SLC11A2										V	V
SLC11A1										V	V
+ 04146: Peroxisome	2.2	0.1	2.2	0.7	3	2.1	0	0.4	0	5.3	2.9	0
FAR1	V		V	V						V	V
PRDX1	V		V	V
MPV17L2	V		V	V
ACSL3		V		V
SOD1		V		V
PEX14					V	V
PEX11B					V
ACOX1					V
HSD17B4					V					V
CAT					V					V
IDH1					V	V				V
FAR2					V					V	V
PHYH						V
IDH2						V				V
PEX5L								V
DHRS4										V
EHHADH										V
PECR										V	V
NUDT12										V
DECR2										V	V
XDH										V
NOS2										V
SLC25A17										V	V
+ 04140: Autophagy - animal	1.1	0.5	1.1	0.8	0.5	1	0	0.2	0.7	0.6	1.3	0
PPP2CB	V		V	V
GABARAP	V		V	V
BNIP3		V		V
SUPT20H		V		V
BECN1		V		V
SH3GLB1		V		V
GABARAPL2		V		V
ATG4A		V		V
CTSD					V
CTSL					V
CTSB					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
HMGB1						V			V
INS									V	V	V
PIK3CD										V
+ 04136: Autophagy - other	2.2	1.3	2.2	2.1	0	0	0	0	0	0	0	0
PPP2CB	V		V	V
GABARAP	V		V	V
BECN1		V		V
GABARAPL2		V		V
ATG4A		V		V
+ 04137: Mitophagy - animal	0.8	2.8	0.9	2.9	0	1.8	0	0	0	0.5	1.3	0
GABARAP	V		V	V
PINK1		V		V						V	V
OPTN		V		V
GABARAPL2		V		V
CSNK2A3		V		V
BNIP3		V		V
RHOT2		V		V
BECN1		V		V
FIS1		V		V
ATF4		V		V
NBR1						V
SP1						V
JUN						V
TP53										V	V
+ 4.2 Cell growth and death	2.2	4	2.3	4.1	4.1	2.2	0.7	1.1	5.1	4.1	6.4	0.5
+ 04110: Cell cycle	1.1	2.3	1.2	2.2	1	0.6	0.1	0.2	1.2	1	2.3	0
YWHAH	V		V	V
YWHAZ	V	V	V	V
CDKN2A		V		V
MAD2L2		V		V
MAD2L1		V		V
YWHAQ		V		V
WEE1		V		V
CCND3		V		V
MAD1L1		V		V
SMC3		V		V
MYC		V		V
HDAC1		V		V						V	V
HDAC2		V		V						V	V
SKP1					V
YWHAE					V	V
CDKN2C					V
E2F2					V
GSK3B						V
CDC14B							V	V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
TP53										V	V
ABL1										V	V
+ 04114: Oocyte meiosis	1.7	2	1.8	2.2	1	0.6	1.1	0.2	0.2	0	0.3	0
YWHAH	V		V	V
YWHAZ	V	V	V	V
PPP2CB	V		V	V
MAD2L2		V		V
MAD2L1		V		V
MAD1L1		V		V
FBXO5		V		V
CAMK2G		V		V
CALM2		V		V
YWHAQ		V		V
PPP1CC		V		V
REC8		V		V
SMC3		V		V
SKP1					V
CPEB4					V
YWHAE					V	V
PPP2R1A					V
PPP2R5A						V
ADCY2							V
ADCY5							V
PGR							V
SPDYA							V	V
INS									V	V	V
+ 04210: Apoptosis	1	0.9	1.1	1.1	2.8	1	0	0.2	2.1	2.6	4.1	0
ACTB	V		V	V
TUBA1C	V		V	V
DFFA		V		V
ENDOG		V		V
LMNB2		V		V
PARP1		V		V						V	V
HTRA2		V		V		V
DAXX		V		V
ATF4		V		V
TUBA8		V		V
CASP7					V
BID					V
TNFSF10					V				V
BAK1					V
BCL2A1					V
MAP3K5					V
CTSB					V
CTSD					V
CTSL					V
CAPN2						V
JUN						V
CTSV								V
TNFRSF1A									V
IL3									V
TNF									V	V	V
FASLG									V
TP53										V	V
AIFM1										V	V
NFKB1										V	V
PIK3CD										V
LMNA										V	V
PARP2										V	V
PARP3										V	V
PARP4										V	V
+ 04215: Apoptosis - multiple species	0	0.7	0	0.6	2.1	0.9	0	0	0.9	0	0	0
HTRA2		V		V		V
BECN1		V		V
CASP7					V
BAK1					V
BID					V
TNFRSF1A									V
+ 04216: Ferroptosis	0	1	0	0.8	1.2	0	0.6	1.6	0	3.2	3.8	0
GPX4		V		V
HMOX1		V		V						V
ACSL3		V		V
VDAC3					V
CYBB					V					V	V
SLC7A11							V	V		V	V
TF								V
TP53										V	V
STEAP3										V	V
SLC11A2										V	V
+ 04217: Necroptosis	2	1.3	2.1	2	1.7	2.5	0	0.1	6.2	2.9	3.7	1.5
PYCARD	V		V	V
CASP1	V		V	V
H2AFY	V		V	V
CHMP2A	V		V	V
IFNG		V		V					V	V	V
FAF1		V		V
SHARPIN		V		V
ZBP1		V		V
SLC25A5		V		V
SLC25A6		V		V
H2AFV		V		V
PARP1		V		V						V	V
CAMK2G		V		V
CHMP4A		V		V
PPID		V		V
TNFSF10					V				V
STAT5A					V
BID					V
H2AFX					V
CYBB					V					V	V
CHMP1A					V
VDAC3					V
TLR4						V						V
IFNB1						V			V
CYLD						V
TLR3						V
STAT1						V
HMGB1						V			V
CAPN2						V
IFNA10							V	V
TNF									V	V	V
TNFRSF1A									V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
FASLG									V
IL33									V
IL1A									V
NLRP3									V
IL1B									V	V	V
GLUD1										V
GLUD2										V
SMPD1										V
AIFM1										V	V
PARP2										V	V
PARP3										V	V
PARP4										V	V
+ 04115: p53 signaling pathway	0	0.4	0	0.3	1.7	0.4	0	0.5	0.5	1.3	2.5	0
CDKN2A		V		V
CCND3		V		V
SHISA5		V		V
RRM2					V
BID					V
TP53I3					V	V				V	V
GTSE1					V
SERPINE1								V
THBS1									V
STEAP3										V	V
TP53										V	V
AIFM2										V	V
+ 04218: Cellular senescence	0.3	2.5	0.4	2.3	0.1	0.4	0	0.4	3.2	0.6	1.5	0
HIPK2	V		V	V
RASSF5		V		V
PPP1CC		V		V
MYC		V		V
CDKN2A		V		V
CCND3		V		V
LIN37		V		V
LIN52		V		V
RAD9A		V		V
MAPKAPK2		V		V
CALM2		V		V
NFATC1		V		V
TGFBR1		V		V
SLC25A5		V		V
SLC25A6		V		V
PPID		V		V
E2F2					V
VDAC3					V
CACNA1D						V
CAPN2						V
GATA4								V
SERPINE1								V
IL1A									V
IL6									V
CXCL8									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
HLA-E									V
HLA-G									V
TP53										V	V
PIK3CD										V
SIRT1										V	V
NFKB1										V	V
+ 4.3 Cellular community - eukaryotes	3.3	1.4	3.2	2.4	0.4	2.7	3.1	2.1	3.7	0.9	2.6	0
+ 04510: Focal adhesion	2.3	0.6	2.3	1.4	0.1	1.3	3	1.4	2.4	0.2	0.8	0
ITGB7	V		V	V
MYL9	V		V	V
PARVB	V		V	V
ZYX	V		V	V
ACTB	V		V	V
ITGB1		V		V
CDC42		V		V
MYL12B		V		V
MYL12A		V		V
PPP1CC		V		V
ILK		V		V	V
PXN		V		V
PRKCB		V		V
CCND3		V		V
RAC2		V		V						V	V
PAK1					V
CAPN2						V
RHOA						V
HGF						V	V
JUN						V
GSK3B						V
ITGA9							V	V
MYLK3							V
MYL10							V
RASGRF1							V
LAMB4							V
THBS2							V
VWF							V
KDR							V	V
PDGFRA							V
SHC4							V
COL4A5								V
COL6A6								V
TNN								V
COL1A2									V
FN1									V
LAMA5									V
SPP1									V
THBS1									V
EGFR									V
VEGFA									V
PIK3CD										V
PDGFB										V	V
RAC1										V	V
+ 04520: Adherens junction	0.8	1.1	0.8	1.2	0.2	0.4	1.3	0.5	0.5	0.9	1.9	0
ACTB	V		V	V
LEF1		V		V
TGFBR1		V		V
CSNK2A3		V		V
RAC2		V		V						V	V
CDC42		V		V
NLK					V
RHOA						V
FGFR1							V
ACP1							V
SORBS1							V
NECTIN4								V
EGFR									V
INSR										V	V
RAC1										V	V
+ 04530: Tight junction	3	1.2	2.6	2.4	0.3	2.4	0.4	2.6	0	0.3	1.4	0
PPP2CB	V		V	V
ACTB	V		V	V
PRKAG2	V			V
TUBA1C	V		V	V
RAB8A	V		V	V
MYL9	V		V	V
PARD6A		V		V
CDC42		V		V
SLC9A3R1		V		V
MSN		V		V
TUBA8		V		V
ACTR2		V		V
NF2		V		V
HSPA4		V		V
ITGB1		V		V
MYL12B		V		V
MYL12A		V		V
PPP2R1A					V
MAP3K5					V
CD1D					V
RHOA						V
CACNA1D						V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
JUN						V
NEDD4L						V
NEDD4						V
PRKAB2							V	V
MYH10							V
CGNL1							V
JAM2								V
AMOT								V
GATA4								V
MYH1								V
MYH7B								V
RAC1										V	V
PRKAG3										V	V
+ 04540: Gap junction	1.4	0.1	1.5	0.3	0.2	0	1.6	0	0.4	0.7	1.7	0
TUBB4B	V		V	V
TUBA1C	V		V	V
PRKCB		V		V
TUBA8		V		V
TUBB					V
PRKG2							V
ADCY2							V
ADCY5							V
PDGFRA							V
EGFR									V
GNAI2										V	V
GNAI3										V	V
PDGFB										V	V
+ 04550: Signaling pathways regulating pluripotency of stem cells	0	0.1	0	0	0	1.9	0.6	0.2	5.1	0	0	0
MYC		V		V
TCF3		V		V
BMI1		V		V
PCGF5		V		V
FZD2					V
WNT5A						V			V
WNT3A						V			V
GSK3B						V
PAX6						V
DLX5						V	V
APC							V
FGFR1							V
FGFR2								V
WNT1									V
WNT2									V
WNT7A									V
LIF									V
IL6ST									V
LIFR									V
INHBA									V
INHBB									V
BMP4									V
FGF2									V
PIK3CD										V
+ 4.5 Cell motility	1.1	0.9	1.2	1.2	0.1	0.5	1.8	0.9	1.4	0.3	1.1	0
+ 04810: Regulation of actin cytoskeleton	1.1	0.9	1.2	1.2	0.1	0.5	1.8	0.9	1.4	0.3	1.1	0
MYL9	V		V	V
ITGB7	V		V	V
ACTB	V		V	V
ARPC2		V		V
ARPC5L		V		V
BRK1		V		V
MSN		V		V
PXN		V		V
PPP1CC		V		V
MYL12B		V		V
MYL12A		V		V
CDC42		V		V
RAC2		V		V						V	V
ITGB1		V		V
F2R		V		V
NCKAP1L					V
LIMK1					V
PAK1					V
RHOA						V
FGF3						V
FGF8						V
APC							V
PIP5K1A							V	V
MYL10							V
MYLK3							V
ITGA9							V	V
FGFR1							V
PDGFRA							V
MYH10							V
FGFR2								V
FGF18								V
F2									V
FN1									V
EGFR									V
FGF2									V
INS									V	V	V
RAC1										V	V
PIK3CD										V
PDGFB										V	V
+ 5. Organismal Systems	5	3.1	4.2	3.9	6.5	8.7	9.3	5.4	12.8	16.1	14.3	1.5
+ 5.1 Immune system	4.7	2.7	4.3	3.6	5.4	12.1	3.4	1.5	23.9	5.3	8.5	3.2
+ 04640: Hematopoietic cell lineage	0	0.2	0	0.1	2.2	1.3	0	0.3	11.1	1.4	2.2	0
CD44		V		V
CD8A		V		V					V
FLT3LG		V		V					V
CD55					V				V	V	V
EPOR					V
CSF3R					V				V
FCGR1A					V
CD1D					V
CD38					V					V
CD3E						V
CD4						V
CD34						V		V
IL1R1									V
IL1R2									V
IL6R									V
IL4R									V
CSF2RA									V
FCER2									V
CD8B									V
IL7R									V
THPO									V
EPO									V
TNF									V	V	V
CSF1									V
CSF3									V
IL11									V
IL6									V
CSF2									V
IL4									V
IL1A									V
IL1B									V	V	V
IL5									V
IL3									V
IL7									V
KITLG									V
CD24										V	V
+ 04610: Complement and coagulation cascades	1.5	0	1.5	0.2	3.9	9.3	3.7	2.2	2.8	0.1	0.5	0
SERPING1	V		V	V	V		V
CLU	V		V	V		V			V
F2R		V		V
C1QA					V	V
C1QB					V	V
C1QC					V	V
CD55					V				V	V	V
SERPINA1					V
PLAUR					V
C3AR1					V
CFD					V	V
MBL2						V
MASP2						V
MASP1						V	V
C1R						V
C1S						V
C3						V
CFH						V
C6						V	V
C7						V
C8A						V
C8B						V	V	V
CD46						V
C4A						V
C4B						V
C2						V	V
CFB						V	V	V
FGB							V
VWF							V
FGA								V
SERPINE1								V
F13A1									V
F2									V
A2M									V
+ 04611: Platelet activation	1.7	1.1	1.8	1.7	0.3	1.6	2.4	0.6	1.2	1	0.7	0
TBXA2R	V		V	V
ACTB	V		V	V
FCER1G	V		V	V		V
F2R		V		V
ITGB1		V		V
PPP1CC		V		V
MYL12B		V		V
MYL12A		V		V
PIK3R5		V		V
STIM1		V		V
SNAP23		V		V
PIK3R6					V
BTK					V
RHOA						V
PTGS1						V
SYK						V
PRKG2							V
MYLK3							V
ADCY2							V
ADCY5							V
VWF							V
COL3A1							V	V	V
FGB							V
FGA								V
COL1A2									V
F2									V
PIK3CD										V
NOS3										V
GNAI2										V	V
GNAI3										V	V
PIK3CG										V
+ 04620: Toll-like receptor signaling pathway	0.6	0	0.6	0.1	1.2	5.4	1.4	0.8	8.2	1.2	2	6.3
CD40	V		V	V
CCL5		V		V		V			V
TAB1		V		V
IRF7					V
CXCL10					V	V	V		V
TLR8					V							V
MAP2K4					V
IFNB1						V			V
STAT1						V
TLR2						V						V
TLR3						V
TLR9						V						V
TLR4						V						V
CCL3						V			V
JUN						V
IL12B						V	V		V
CCL4						V			V
CXCL11							V	V
IFNA10							V	V
SPP1									V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
CXCL8									V
IL1B									V	V	V
IL6									V
TNF									V	V	V
LBP									V
CXCL9									V
IL12A									V
NFKB1										V	V
RAC1										V	V
PIK3CD										V
TIRAP												V
TLR1												V
+ 04621: NOD-like receptor signaling pathway	4.3	0.3	3.5	1.7	1.2	3.5	0.7	0.1	6.6	1.3	2.7	1.5
PYCARD	V		V	V
CASP1	V		V	V
SUGT1	V	V	V	V
GSDMD	V		V	V
GBP1	V		V	V					V
TXN	V			V						V	V
GABARAP	V		V	V
CYBA	V		V	V						V	V
CARD16	V			V
TAB1		V		V
MAVS		V		V
SHARPIN		V		V
GABARAPL2		V		V
TMEM173		V		V
CCL5		V		V		V			V
IRF7					V
VDAC3					V
CYBB					V					V	V
NLRX1					V
CTSB					V
OAS1					V		V
NOD2						V
AIM2						V
JUN						V
STAT1						V
TLR4						V						V
RHOA						V
IFNB1						V			V
PYDC5						V
IFI16						V
IFNA10							V	V
OAS3							V
CCL2							V		V
NLRP3									V
IL1B									V	V	V
IL18									V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
NAMPT									V	V
IL6									V
TNF									V	V	V
CXCL8									V
CXCL1									V
CXCL2									V
P2RX7										V	V
NFKB1										V	V
+ 04622: RIG-I-like receptor signaling pathway	0.8	0.4	0.8	0.6	1.2	2.3	2.9	0.5	6.8	0.9	1.9	0
ISG15	V		V	V			V
MAVS		V		V
TMEM173		V		V
PIN1		V		V						V	V
IRF7					V
NLRX1					V
CXCL10					V	V	V		V
IFNB1						V			V
CYLD						V
IL12B						V	V		V
IFNA10							V	V
IFNE							V
IFNK							V		V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
IFNW1									V
CXCL8									V
TNF									V	V	V
IL12A									V
NFKB1										V	V
+ 04623: Cytosolic DNA-sensing pathway	1.7	2.9	1.7	3.3	0.8	3.6	0.9	0.5	7	0.6	1.3	0
CASP1	V		V	V
PYCARD	V		V	V
ZBP1		V		V
MAVS		V		V
TMEM173		V		V
POLR1D		V		V
POLR2E		V		V
POLR2H		V		V
POLR2K		V		V
POLR3GL		V		V
CCL5		V		V		V			V
IRF7					V
CXCL10					V	V	V		V
AIM2						V
IFNB1						V			V
CCL4						V			V
TREX1						V
IFNA10							V	V
IL1B									V	V	V
IL18									V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
IL6									V
IL33									V
NFKB1										V	V
+ 04625: C-type lectin receptor signaling pathway	1.9	0.3	2	0.9	1.2	4.6	0.1	0	5.3	1.2	1.5	1.7
FCER1G	V		V	V		V
CASP1	V		V	V
PYCARD	V		V	V
LSP1		V		V
MAPKAPK2		V		V
NFATC1		V		V
CALM2		V		V
PAK1					V
BCL3					V
NFKB2					V
EGR2					V	V
SYK						V
IL23A						V			V
IL12B						V	V		V
RHOA						V
CYLD						V
STAT1						V
IRF1						V
JUN						V
IL12A									V
NLRP3									V
IL1B									V	V	V
IL6									V
IL17D									V
IL10									V
IL2									V
TNF									V	V	V
CCL22									V
NFKB1										V	V
PIK3CD										V
PTGS2										V
CD209												V
+ 04650: Natural killer cell mediated cytotoxicity	1.1	0.5	1.1	0.7	1.3	1.5	0.3	0.2	6.3	0.9	1.8	0
FCER1G	V		V	V		V
TYROBP	V		V	V
NFATC1		V		V
LAT		V		V
IFNG		V		V					V	V	V
PRKCB		V		V
CD48		V		V
RAC2		V		V						V	V
TNFSF10					V				V
BID					V
MICB					V
ICAM1					V
PAK1					V
SYK						V
ZAP70						V
IFNB1						V			V
IFNA10							V	V
SHC4							V
HLA-E									V
CSF2									V
TNF									V	V	V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
ULBP2									V
HLA-G									V
FASLG									V
RAET1G									V
PIK3CD										V
RAC1										V	V
+ 04612: Antigen processing and presentation	1.5	1	0	1.4	2.1	0.4	0	0	4	0.4	1.2	0
CALR	V			V
PSME2	V			V
CD8A		V		V					V
TAPBP		V		V
CANX		V		V
HSPA4		V		V
IFNG		V		V					V	V	V
CTSB					V
CTSL					V
IFI30					V
HSPA1B					V
HSPA6					V
CD4						V
CD8B									V
B2M									V
HLA-E									V
HLA-G									V
TNF									V	V	V
+ 04660: T cell receptor signaling pathway	0	0.6	0	0.4	0.1	3.8	0.2	0	4.9	0.9	1.5	0
IFNG		V		V					V	V	V
NFATC1		V		V
LAT		V		V
CDC42		V		V
CD8A		V		V					V
PAK1					V
CD28						V
CD40LG						V			V
JUN						V
RHOA						V
ZAP70						V
CD3E						V
CD4						V
GSK3B						V
TEC							V
TNF									V	V	V
CSF2									V
IL10									V
IL5									V
IL4									V
IL2									V
CD8B									V
NFKB1										V	V
PIK3CD										V
+ 04658: Th1 and Th2 cell differentiation	0	0.4	0	0.3	0.5	3.5	0.2	0	4.2	0.6	1.6	0
IFNG		V		V					V	V	V
NFATC1		V		V
LAT		V		V
GATA3		V		V		V
IL12RB1					V
STAT5A					V
ZAP70						V
CD3E						V
JUN						V
CD4						V
STAT1						V
IL12B						V	V		V
IL5									V
IL12A									V
IL4									V
IL4R									V
IL13									V	V	V
IL2									V
NFKB1										V	V
+ 04659: Th17 cell differentiation	0	0.5	0	0.3	0.4	3.2	0	0	7.5	0.8	2	0
NFATC1		V		V
LAT		V		V
IFNG		V		V					V	V	V
TGFBR1		V		V
GATA3		V		V		V
STAT5A					V
IL12RB1					V
ZAP70						V
JUN						V
CD4						V
STAT1						V
IL23A						V			V
CD3E						V
IL4									V
IL4R									V
IL2									V
IL1R1									V
IL1RAP									V
IL6R									V
IL6ST									V
IL21									V
IL17A									V
IL17F									V
IL22									V
TGFB1									V	V	V
IL1B									V	V	V
IL17D									V
IL6									V
NFKB1										V	V
+ 04657: IL-17 signaling pathway	0.6	0	0.7	0	0.9	1.9	0.6	0.3	12.4	1.8	2.8	3
CEBPB	V		V	V
IFNG		V		V					V	V	V
LCN2					V				V
CXCL10					V	V	V		V
S100A9					V				V
JUN						V
GSK3B						V
S100A7						V
CCL2							V		V
MMP3								V	V
IL6									V
IL25									V
IL17RA									V
IL17RB									V
IL17A									V
IL17F									V
IL17C									V
IL17B									V
IL17D									V
CXCL1									V
CXCL2									V
CCL20									V
MMP9									V			V
IL4									V
IL5									V
IL13									V	V	V
CXCL8									V
CSF2									V
CCL11									V
MMP1									V			V
TNF									V	V	V
CXCL6									V
CSF3									V
S100A8									V
IL1B									V	V	V
NFKB1										V	V
PTGS2										V
+ 04662: B cell receptor signaling pathway	0	0.3	0	0.2	1.1	1.5	0	0	1.1	1.2	1.8	0
PRKCB		V		V
NFATC1		V		V
RAC2		V		V						V	V
BTK					V
LILRB2					V
LILRA3					V
GSK3B						V
JUN						V
SYK						V
LILRB1									V
LILRA2									V
NFKB1										V	V
PIK3CD										V
RAC1										V	V
+ 04664: Fc epsilon RI signaling pathway	0.8	0.2	0.8	0.3	1.3	1.1	0	0	3.6	1.9	2.6	0
FCER1G	V		V	V		V
LAT		V		V
RAC2		V		V						V	V
MAP2K4					V
BTK					V
ALOX5					V
SYK						V
TNF									V	V	V
IL13									V	V	V
IL4									V
CSF2									V
IL5									V
IL3									V
PIK3CD										V
RAC1										V	V
+ 04666: Fc gamma R-mediated phagocytosis	0	1.4	0	1.1	1.3	0.3	0.2	0.3	0	2.3	2.2	0
HCK		V		V	V					V	V
LAT		V		V
RAC2		V		V						V	V
ARPC2		V		V
ARPC5L		V		V
CDC42		V		V
PRKCB		V		V
FCGR1A					V
PAK1					V
LIMK1					V
SYK						V
PIP5K1A							V	V
PIK3CD										V
RAC1										V	V
NCF1										V	V
SPHK2										V
SPHK1										V
+ 04670: Leukocyte transendothelial migration	2.5	1.6	2.5	2.5	0.7	0.2	0.1	0.3	0.8	3.1	4.4	1.7
ACTB	V		V	V
MYL9	V		V	V
CYBA	V		V	V						V	V
NCF4	V		V	V						V	V
ITGB1		V		V
MYL12B		V		V
MYL12A		V		V
PRKCB		V		V
PXN		V		V
RAC2		V		V						V	V
MSN		V		V
RASSF5		V		V
CDC42		V		V
ESAM					V
CYBB					V					V	V
ICAM1					V
RHOA						V
MYL10							V
JAM2								V
MMP2									V
MMP9									V			V
PIK3CD										V
NCF2										V	V
NCF1										V	V
RAC1										V	V
GNAI2										V	V
GNAI3										V	V
+ 04672: Intestinal immune network for IgA production	1.9	0	1.9	0.3	1	1.4	0	0	6.6	0.3	0.8	0
CD40	V		V	V
ITGB7	V		V	V
TNFSF13B					V				V
IL15RA					V				V
CD40LG						V			V
CD28						V
TGFB1									V	V	V
IL5									V
IL6									V
TNFSF13									V
IL10									V
IL15									V
IL4									V
IL2									V
+ 04062: Chemokine signaling pathway	0	0.2	0	0.1	1.7	3.8	1.6	0.7	6.5	1.5	2.6	0
CCL5		V		V		V			V
HCK		V		V	V					V	V
PXN		V		V
CDC42		V		V
PRKCB		V		V
RAC2		V		V						V	V
PIK3R5		V		V
CCR1					V
CXCL10					V	V	V		V
PPBP					V
GNG10					V
ELMO1					V
PAK1					V
PIK3R6					V
CCR2						V
CXCL13						V
CCL4						V			V
CCL3						V			V
CCL21						V
XCL1						V			V
RHOA						V
STAT1						V
GSK3B						V
CCL2							V		V
CCL18							V	V
CXCL11							V	V
SHC4							V
ADCY2							V
ADCY5							V
GNG3								V
CXCL1									V
CXCL2									V
CXCL8									V
CXCL9									V
PF4									V
CXCL16									V
CCL11									V
CCL19									V
CCL20									V
CCL22									V
CXCL6									V
CX3CL1									V
PIK3CD										V
GNAI2										V	V
GNAI3										V	V
NCF1										V	V
RAC1										V	V
NFKB1										V	V
PIK3CG										V
+ 5.2 Endocrine system	1.8	1.1	1.3	1.1	2.4	3.4	6.1	2.9	6.2	9.2	8.1	1.4
+ 04911: Insulin secretion	0	0.3	0	0.2	1	0.9	3.1	0.9	1	0.7	1.1	0
PRKCB		V		V
ATF4		V		V
CAMK2G		V		V
ATP1B2					V
KCNMB1					V
KCNN4					V
CACNA1D						V
FFAR1						V
ADCY2							V
ADCY5							V
ATP1B4							V
SNAP25							V
KCNMB2							V	V
KCNMB4							V
KCNMA1							V
RYR2								V		V	V
INS									V	V	V
STX1A									V
GCK										V
+ 04910: Insulin signaling pathway	1.6	0	1.1	0.2	2	0.9	0.6	0.5	0.2	2.6	2.7	0
SOCS1	V		V	V
PRKAG2	V			V
PRKAR2B	V		V	V
PPP1CC		V		V
CALM2		V		V
EXOC7		V		V
SOCS3					V
MKNK2					V
PRKAR1A					V
PCK2					V
FBP1					V
HK1					V
HK3					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
GSK3B						V
PRKAB2							V	V
SHC4							V
SORBS1							V
INS									V	V	V
FASN										V
PRKAG3										V	V
INSR										V	V
PPARGC1A										V	V
PIK3CD										V
GCK										V
HK2										V
+ 04922: Glucagon signaling pathway	0.6	0.3	0	0.4	0.4	0.7	0.5	0.8	0	6.3	2.6	0
PRKAG2	V			V
ATF4		V		V
PPP4C		V		V
CALM2		V		V
CAMK2G		V		V
PCK2					V
FBP1					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
ADCY2							V
PRKAB2							V	V
PDHA1										V
PDHA2										V
PDHB										V
GCK										V
PFKL										V
PGAM4										V
PGAM1										V
PGAM2										V
PPARGC1A										V	V
PFKFB1										V
PRKAG3										V	V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
SIRT1										V	V
+ 04923: Regulation of lipolysis in adipocytes	0	0	0	0	0.3	0.6	2.8	1.3	0.6	3.2	3.4	0
MGLL					V
PTGS1						V
ADCY2							V
ADCY5							V
PRKG2							V
PTGER3							V	V
TSHB							V
NPY1R								V
INS									V	V	V
GNAI2										V	V
GNAI3										V	V
INSR										V	V
PIK3CD										V
PTGS2										V
TSHR										V	V
+ 04920: Adipocytokine signaling pathway	0.8	0	0	0.1	0.7	1.1	0.3	1.1	3.6	2.4	3.7	0
PRKAG2	V			V
ACSL3		V		V
SOCS3					V
PCK2					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
PRKAB2							V	V
LEP									V
POMC									V
ADIPOQ									V
TNFRSF1B									V
TNFRSF1A									V
TNF									V	V	V
NFKB1										V	V
PRKAG3										V	V
PPARGC1A										V	V
+ 03320: PPAR signaling pathway	0	0.7	0	0.5	1.6	0	0.7	1.7	2.4	2.7	0	1.9
ACADM		V		V
ACSL3		V		V
ILK		V		V	V
DBI		V		V
GK					V
PCK2					V
ACOX1					V
ACADL							V	V
SORBS1							V
FABP3								V
UCP1								V
MMP1									V			V
APOA2									V
ADIPOQ									V
APOA1									V
CYP4A11										V
CYP4A22										V
EHHADH										V
CYP7A1										V
CYP27A1										V
ME3										V
ME1										V
+ 04912: GnRH signaling pathway	0	0.7	0	0.5	0.1	0.8	0.6	0	0.9	0	0	0
PRKCB		V		V
CDC42		V		V
ATF4		V		V
CAMK2G		V		V
CALM2		V		V
MAP2K4					V
CACNA1D						V
JUN						V
ADCY2							V
ADCY5							V
MMP2									V
EGFR									V
+ 04913: Ovarian steroidogenesis	1	0	1	0.1	0.4	0	1.7	0	0.7	5.6	1.5	0
BMP6	V		V	V
ALOX5					V
ADCY2							V
ADCY5							V
CYP19A1							V
INS									V	V	V
HSD3B1										V
HSD3B2										V
HSD17B2										V
AKR1C3										V
CYP17A1										V
CYP1A1										V
HSD17B1										V
HSD17B7										V
INSR										V	V
CYP2J2										V
PTGS2										V
+ 04915: Estrogen signaling pathway	0	0	0	0	0.5	0.5	2.6	0.2	1.6	0.5	0.7	1.6
ATF4		V		V
CALM2		V		V
EBAG9		V		V
HSPA1B					V
HSPA6					V
CTSD					V
JUN						V
SP1						V
ESR2							V	V
ADCY2							V
ADCY5							V
KCNJ3							V
GABBR2							V
SHC4							V
KRT25							V
PGR							V
MMP2									V
MMP9									V			V
EGFR									V
POMC									V
PIK3CD										V
NOS3										V
GNAI2										V	V
GNAI3										V	V
+ 04914: Progesterone-mediated oocyte maturation	0	0.2	0	0.1	0.1	0	1.5	0.3	0.4	1	1.6	0
MAD2L2		V		V
MAD2L1		V		V
MAD1L1		V		V
CPEB4					V
ADCY2							V
ADCY5							V
SPDYA							V	V
PGR							V
INS									V	V	V
PIK3CD										V
GNAI2										V	V
GNAI3										V	V
+ 04917: Prolactin signaling pathway	0.8	0	0.8	0	1.2	1.7	1.4	0.5	1.8	1.9	1.2	0
SOCS1	V		V	V
STAT5A					V
SOCS3					V
CISH					V
STAT1						V
IRF1						V
GSK3B						V
SHC4							V
ESR2							V	V
TNFRSF11A							V
PRLR									V
TNFSF11									V
INS									V	V	V
PIK3CD										V
GCK										V
CYP17A1										V
NFKB1										V	V
+ 04921: Oxytocin signaling pathway	1.5	0.3	1	0.6	0.2	2.6	1.6	1.4	0.2	2.7	3	0
MYL9	V		V	V
ACTB	V		V	V
PRKAG2	V			V
CALM2		V		V
PRKCB		V		V
CAMK2G		V		V
PPP1CC		V		V
NFATC1		V		V
PIK3R5		V		V
CD38					V					V
PIK3R6					V
EEF2K						V		V
RHOA						V
CACNA1D						V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
JUN						V
MEF2C						V
MYLK3							V
ADCY2							V
ADCY5							V
CACNG2							V
PRKAB2							V	V
KCNJ3							V
RYR2								V		V	V
EGFR									V
CAMK1D										V	V
NOS3										V
PTGS2										V
PRKAG3										V	V
GNAI2										V	V
GNAI3										V	V
PIK3CG										V
+ 04926: Relaxin signaling pathway	0	0	0	0	0.2	0.2	1.1	1.1	4	2	1.8	2.8
ATF4		V		V
TGFBR1		V		V
GNG10					V
MAP2K4					V
JUN						V
ADCY5							V
COL3A1							V	V	V
ADCY2							V
SHC4							V
GNG3								V
COL4A5								V
EDN1									V
VEGFA									V
MMP2									V
MMP9									V			V
TGFB1									V	V	V
COL1A2									V
MMP1									V			V
EGFR									V
NFKB1										V	V
NOS3										V
PIK3CD										V
GNAI2										V	V
GNAI3										V	V
NOS2										V
NOS1										V
+ 04918: Thyroid hormone synthesis	0	0.4	0	0.2	0.6	0	1.8	1.1	0	0.9	1.2	0
PRKCB		V		V
ATF4		V		V
CANX		V		V
ATP1B2					V
ASGR2					V
TSHB							V
ADCY2							V
ADCY5							V
ATP1B4							V
PAX8								V
GPX8								V
TSHR										V	V
DUOX2										V	V
GSR										V
+ 04919: Thyroid hormone signaling pathway	0.5	0.9	0.5	0.9	0.3	0.6	0.4	1.7	0.3	2.2	2.9	0
ACTB	V		V	V
PRKCB		V		V
ATP2A3		V		V
HDAC1		V		V						V	V
HDAC2		V		V						V	V
MED4		V		V
MED12		V		V
MYC		V		V
ATP1B2					V
KAT2B					V					V	V
GSK3B						V
STAT1						V
MYH6							V	V
ATP1B4							V
PLCE1								V
GATA4								V
SLC16A2								V
BMP4									V
PIK3CD										V
TP53										V	V
PFKFB2										V
HDAC3										V	V
KAT2A										V	V
+ 04928: Parathyroid hormone synthesis, secretion and action	0	0.3	0	0.2	0.4	1.8	1.3	0	0.8	0.8	1.5	0
GATA3		V		V		V
PRKCB		V		V
SLC9A3R1		V		V
ATF4		V		V
VDR					V					V	V
MAFB					V
RHOA						V
MEF2C						V
SP1						V
ADCY2							V
ADCY5							V
PDE4A							V
FGFR1							V
EGFR									V
TNFSF11									V
GNAI2										V	V
GNAI3										V	V
CYP27B1										V
+ 04916: Melanogenesis	0	0.3	0	0.2	0.1	1.3	0.5	0	4	0.5	0.9	0
CAMK2G		V		V
CALM2		V		V
LEF1		V		V
PRKCB		V		V
FZD2					V
GSK3B						V
WNT5A						V			V
WNT3A						V			V
ADCY2							V
ADCY5							V
KITLG									V
POMC									V
WNT1									V
WNT2									V
WNT7A									V
EDN1									V
TYR										V
GNAI2										V	V
GNAI3										V	V
+ 04924: Renin secretion	0	0	0	0	0.2	0.5	1.4	0.5	1.8	1.4	2.6	0
CALM2		V		V
CTSB					V
CACNA1D						V
ADCY5							V
PRKG2							V
KCNMA1							V
CLCA2								V
AGT									V	V	V
EDN1									V
EDN2									V
GNAI2										V	V
GNAI3										V	V
AGTR1										V	V
+ 04614: Renin-angiotensin system	1.4	0	1.4	0.3	0	0	1.7	0	2.1	1.4	2.1	0
CTSA	V		V	V
AGTR2							V
NLN							V
ACE2									V
AGT									V	V	V
AGTR1										V	V
+ 04925: Aldosterone synthesis and secretion	0	0.6	0	0.4	0.4	0.3	1.5	0	0.9	1.3	1.5	0
ATF4		V		V
CALM2		V		V
PRKCB		V		V
CAMK2G		V		V
ATF1		V		V
PRKD2					V
ATP1B2					V
CACNA1D						V
ADCY2							V
ADCY5							V
ATP1B4							V
ATP2B2							V
POMC									V
AGT									V	V	V
AGTR1										V	V
CAMK1D										V	V
HSD3B1										V
HSD3B2										V
+ 04927: Cortisol synthesis and secretion	0	0	0	0	0	1.1	0.9	0	1.2	2	1.3	0
ATF4		V		V
CACNA1D						V
SP1						V
ADCY2							V
ADCY5							V
POMC									V
AGT									V	V	V
AGTR1										V	V
HSD3B1										V
HSD3B2										V
CYP17A1										V
+ 5.3 Circulatory system	1.6	1.1	1.7	1.5	0.5	0.8	3	1.2	1	3.2	1.9	0
+ 04260: Cardiac muscle contraction	1.4	1.2	1.5	1.6	0.2	0.3	1.1	0.9	0	4	0.4	0
TPM4	V		V	V
COX7B	V		V	V						V
ATP2A3		V		V
TPM3		V		V
UQCRHL		V		V
UQCRB		V		V
UQCRH		V		V
COX7A2L		V		V						V
ATP1B2					V
CACNA1D						V
CACNG2							V
MYH6							V	V
ATP1B4							V
RYR2								V		V	V
COX6B1										V
COX6C										V
COX7A1										V
COX7A2										V
COX8A										V
COX7B2										V
COX8C										V
COX4I2										V
+ 04261: Adrenergic signaling in cardiomyocytes	0.9	0.5	1	0.7	0.4	0.4	2.1	0.5	0.2	1	2.1	0
TPM4	V		V	V
PPP2CB	V		V	V
ATP2A3		V		V
TPM3		V		V
PIK3R5		V		V
ATF4		V		V
PPP1CC		V		V
CALM2		V		V
CAMK2G		V		V
ATP1B2					V
PIK3R6					V
PPP2R1A					V
CACNA1D						V
PPP2R5A						V
CACNG2							V
MYH6							V	V
ATP1B4							V
ADCY2							V
ADCY5							V
AGTR2							V
ATP2B2							V
RYR2								V		V	V
AGT									V	V	V
GNAI2										V	V
GNAI3										V	V
PIK3CG										V
AGTR1										V	V
+ 04270: Vascular smooth muscle contraction	0.4	0.3	0.5	0.3	0.2	0.5	1.9	0.6	1.6	0.6	0.7	0
MYL9	V		V	V
PPP1CC		V		V
PRKCB		V		V
PRKCH		V		V
CALM2		V		V
PLA2G12A		V		V
KCNMB1					V
ADM					V
RHOA						V
CACNA1D						V
MYLK3							V
KCNMB2							V	V
KCNMB4							V
KCNMA1							V
ADCY2							V
ADCY5							V
PLA2G2F								V
PLA2G5									V
AGT									V	V	V
EDN1									V
EDN2									V
CYP4A11										V
CYP4A22										V
AGTR1										V	V
+ 5.4 Digestive system	0.4	0.4	0.4	0.4	4.2	0.5	4.7	3.6	2.1	3.4	3.1	0
+ 04970: Salivary secretion	0	0.1	0	0	1.9	0	3	0.4	0	1.1	0.4	0
PRKCB		V		V
CALM2		V		V
BST1					V					V
CD38					V					V
KCNN4					V
ATP1B2					V
LYZ					V
ADCY2							V
ADCY5							V
ATP2B2							V
AQP5							V	V
PRKG2							V
KCNMA1							V
ATP1B4							V
NOS1										V
LPO										V	V
+ 04971: Gastric acid secretion	0.7	0.4	0.8	0.5	0.6	0	2.3	0	0	0.4	1.2	0
ACTB	V		V	V
PRKCB		V		V
CALM2		V		V
CAMK2G		V		V
ATP1B2					V
CA2					V
ADCY2							V
ADCY5							V
ATP1B4							V
SLC26A7							V
MYLK3							V
GNAI2										V	V
GNAI3										V	V
+ 04972: Pancreatic secretion	0.6	0.2	0.6	0.2	1.8	0.3	2.4	2.5	0.3	0.9	1	0
RAB8A	V		V	V
PRKCB		V		V
PLA2G12A		V		V
ATP2A3		V		V
ATP1B2					V
CA2					V
BST1					V					V
CD38					V					V
RAB27B					V
RHOA						V
ATP2B2							V
KCNMA1							V
ATP1B4							V
PNLIPRP2							V
ADCY2							V
ADCY5							V
CLCA2								V
RYR2								V		V	V
CPA1								V
PLA2G2F								V
CTRB1								V
PLA2G5									V
RAC1										V	V
+ 04976: Bile secretion	0	0	0	0	0.7	0	3.4	1.1	0	2.7	2.5	0
ATP1B2					V
CA2					V
ATP1B4							V
ADCY2							V
ADCY5							V
SLCO1B7							V
SLCO1A2							V
SULT2A1							V	V
SLC9A3							V
ABCC4								V		V	V
SLCO1B1										V	V
SLCO1B3										V	V
ABCB11										V	V
CYP7A1										V
CYP3A4										V
HMGCR										V
+ 04973: Carbohydrate digestion and absorption	0	0.1	0	0.1	1.7	0.7	0.5	0	0	0.9	0	0
PRKCB		V		V
ATP1B2					V
HK1					V
HK3					V
CACNA1D						V
ATP1B4							V
HK2										V
PIK3CD										V
+ 04974: Protein digestion and absorption	0	0	0	0	0.9	0	1.6	3.6	2.1	0	0	0
SLC1A5					V
ATP1B2					V
KCNN4					V
ATP1B4							V
SLC9A3							V
COL3A1							V	V	V
COL5A1							V	V
CTRB1								V
CPA1								V
COL4A5								V
COL6A6								V
COL14A1								V
DPP4									V
ACE2									V
COL1A2									V
+ 04975: Fat digestion and absorption	0	0.2	0	0.1	0	0.8	0.6	0.8	1.7	0	0	0
PLA2G12A		V		V
GOT2						V
PNLIPRP2							V
PLA2G2F								V
PLA2G5									V
APOA1									V
+ 04979: Cholesterol metabolism	0	0	0	0	2.2	0	0	0.7	1.5	1.3	0.8	0
VAPA					V
NPC2					V
VDAC3					V
TSPO					V
APOC1								V
APOA1									V
APOA2									V
CYP27A1										V
CYP7A1										V
ABCB11										V	V
+ 04977: Vitamin digestion and absorption	0	0	0	0	0.8	0	0	1.1	1.1	0.7	1.2	0
TCN2					V
LRAT								V
APOA1									V
MMACHC										V	V
+ 04978: Mineral absorption	0	0.3	0	0.2	2.6	0	1	1.4	0	2.8	2.9	0
HMOX1		V		V						V
MT1F		V		V
VDR					V					V	V
SLC39A4					V
SLC31A1					V
MT1E					V
ATP1B2					V
SLC9A3							V
ATP1B4							V
TF								V
STEAP1								V
CYBRD1										V	V
SLC11A2										V	V
HMOX2										V
ATP7A										V	V
+ 5.5 Excretory system	1	0.8	1	1	2.9	0.4	1.9	0.4	0.4	2.8	2	0
+ 04962: Vasopressin-regulated water reabsorption	0	0.9	0	0.7	0.5	0	0	0	0	0.3	0.8	0
AQP3		V		V
RAB11B		V		V
DYNLL2		V		V
ARHGDIA					V
ARHGDIB										V	V
+ 04960: Aldosterone-regulated sodium reabsorption	0	0.2	0	0.1	1.2	0.8	1.3	0.8	0.9	2.2	1.8	0
PRKCB		V		V
ATP1B2					V
SGK1					V
NEDD4L						V
SCNN1G							V
ATP1B4							V
SCNN1B								V
INS									V	V	V
HSD11B2										V
INSR										V	V
PIK3CD										V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	1	0.4	1	0.6	1	0	1.1	0	0	0.3	0.7	0
AP2S1	V		V	V
AP2A2		V		V
PRKCB		V		V
VDR					V					V	V
ATP1B2					V
CLTB							V
ATP1B4							V
+ 04964: Proximal tubule bicarbonate reclamation	0	0	0	0	2.4	0	1.7	0	0	2.8	0	0
CA2					V
ATP1B2					V
PCK2					V
SLC9A3							V
ATP1B4							V
GLS										V
GLUD1										V
GLUD2										V
MDH1										V
+ 04966: Collecting duct acid secretion	1.3	0.3	1.3	0.7	1.5	0	0	0	0	0.6	1.1	0
ATP6V0E1	V		V	V
ATP6V1G1		V		V
ATP6V1E1					V
CA2					V
SLC4A1										V	V
+ 5.6 Nervous system	1.6	1	1.7	1.1	1.3	2.5	3.1	1.6	0.3	6.3	3.5	0
+ 04724: Glutamatergic synapse	0	0	0	0	0.1	0.2	0.8	0.2	0	0.7	1.4	0
PRKCB		V		V
HOMER2		V		V
GNG10					V
CACNA1D						V
ADCY2							V
ADCY5							V
KCNJ3							V
GNG3								V
SLC1A3										V	V
GNAI2										V	V
GNAI3										V	V
GLS										V
+ 04727: GABAergic synapse	0.6	0.1	0.7	0.1	0.5	0.3	3	2.1	0	0.7	1	0
GABARAP	V		V	V
GABARAPL2		V		V
PRKCB		V		V
SLC6A12					V
GNG10					V
CACNA1D						V
GABBR2							V
SLC6A11							V	V
ADCY2							V
ADCY5							V
GABRA4							V
GABRA6							V
GABRG2							V
GAD1								V
GNG3								V
GABRA5								V
GNAI2										V	V
GNAI3										V	V
GLS										V
+ 04725: Cholinergic synapse	0	0.2	0	0.1	0.3	2.7	0.8	0.2	0	1.1	0.8	0
PRKCB		V		V
ATF4		V		V
CAMK2G		V		V
PIK3R5		V		V
GNG10					V
PIK3R6					V
CHRNA3						V
CHRNA4						V
CHRNA7						V
CHRNB2						V
CHRNB4						V
CACNA1D						V
ADCY2							V
ADCY5							V
KCNJ3							V
GNG3								V
CHAT										V
GNAI2										V	V
GNAI3										V	V
PIK3CD										V
PIK3CG										V
+ 04728: Dopaminergic synapse	0.4	0.3	0.5	0.3	0.2	1	0.3	0.2	0	0.9	2.3	0
PPP2CB	V		V	V
PRKCB		V		V
ATF4		V		V
CAMK2G		V		V
PPP1CC		V		V
CALM2		V		V
GNG10					V
PPP2R1A					V
GSK3B						V
PPP2R5A						V
CACNA1D						V
ADCY5							V
KCNJ3							V
GNG3								V
DRD5										V	V
GNAI2										V	V
GNAI3										V	V
CLOCK										V	V
ARNTL										V	V
+ 04726: Serotonergic synapse	0.5	0	0.5	0	0.3	0.6	0.8	0.2	0.3	2.6	0.8	0
ALOX12	V		V	V						V
PRKCB		V		V
GNG10					V
ALOX5					V
CACNA1D						V
PTGS1						V
ADCY5							V
HTR3B							V
KCNJ3							V
GNG3								V
APP									V
GNAI2										V	V
GNAI3										V	V
CYP2C19										V
CYP2C8										V
CYP2C9										V
CYP2D6										V
CYP2J2										V
PTGS2										V
+ 04720: Long-term potentiation	0	1.2	0	1	0	0	0	0	0	0	0	0
PRKCB		V		V
CAMK2G		V		V
CALM2		V		V
ATF4		V		V
PPP1CC		V		V
+ 04730: Long-term depression	0.9	0.1	0.9	0.2	0.3	0	0.4	0	0	1.1	1.4	0
PPP2CB	V		V	V
PRKCB		V		V
PPP2R1A					V
PRKG2							V
GNAI2										V	V
GNAI3										V	V
NOS1										V
+ 04723: Retrograde endocannabinoid signaling	0.4	0.5	0.4	0.5	0.4	1.3	1.7	0.9	0	11.2	0.6	0
NDUFB3	V		V	V						V
PRKCB		V		V
NDUFA11		V		V						V
NDUFA6		V		V						V
NDUFA10		V		V						V
NDUFC1		V		V	V					V
NDUFS5		V		V						V
NDUFB11		V		V						V
GNG10					V
MGLL					V
CACNA1D						V
NDUFS7						V				V
NDUFS2						V				V
NDUFA13						V				V
GABRA4							V
GABRA6							V
GABRG2							V
KCNJ3							V
ADCY2							V
ADCY5							V
GABRA5								V
GNG3								V
RIMS1								V
PTGS2										V
GNAI2										V	V
GNAI3										V	V
NDUFC2-KCTD14										V
NDUFA1										V
NDUFA2										V
NDUFA3										V
NDUFA4										V
NDUFA5										V
NDUFA7										V
NDUFA8										V
NDUFA9										V
NDUFAB1										V
NDUFB1										V
NDUFB2										V
NDUFB4										V
NDUFB5										V
NDUFB6										V
NDUFB7										V
NDUFB8										V
NDUFB9										V
NDUFB10										V
NDUFC2										V
NDUFS1										V
NDUFS3										V
NDUFV1										V
NDUFS4										V
NDUFS6										V
NDUFS8										V
NDUFV2										V
NDUFV3										V
NDUFA12										V
+ 04721: Synaptic vesicle cycle	2.2	0.1	2.3	0.7	0.6	0	1.8	1	0.5	0.1	0.5	0
NAPA	V		V	V
AP2S1	V		V	V
ATP6V0E1	V		V	V
AP2A2		V		V
ATP6V1G1		V		V
ATP6V1E1					V
SLC6A12					V
SNAP25							V
CLTB							V
SLC6A2							V
SLC6A11							V	V
RIMS1								V
STX1A									V
SLC1A3										V	V
+ 04722: Neurotrophin signaling pathway	0	0.6	0	0.4	1.4	1.6	0.4	0	0.3	1.4	2.4	0
ATF4		V		V
CAMK2G		V		V
MAPKAPK2		V		V
SH2B1		V		V
CDC42		V		V
CALM2		V		V
MAP3K5					V
ARHGDIA					V
SH2B3					V
YWHAE					V	V
PSEN2					V
GSK3B						V
RHOA						V
JUN						V
SHC4							V
GAB1							V
FASLG									V
PIK3CD										V
NFKB1										V	V
TP53										V	V
ARHGDIB										V	V
ABL1										V	V
RAC1										V	V
+ 5.7 Sensory system	0.3	0.5	0.3	0.5	0	0.5	2.2	1.4	0.7	0.9	0.2	0
+ 04744: Phototransduction	0	0.3	0	0.3	0	0	0.8	1.9	0	0	0	0
CALM2		V		V
CNGA1							V
GNAT1								V
RCVRN								V
+ 04740: Olfactory transduction	0	0	0	0	0	0	0	0	0	0	0	0
CAMK2G		V		V
CALM2		V		V
PRKG2							V
+ 04742: Taste transduction	0	0	0	0	0	0.9	2.2	1	0	0	0	0
P2RX2						V
P2RX3						V
SCNN1G							V
GABRA4							V
GABRA6							V
GABBR2							V
HTR3B							V
SCNN1B								V
GABRA5								V
+ 04750: Inflammatory mediator regulation of TRP channels	0.6	0.6	0.6	0.7	0	0	1.4	0	1.4	1.7	0.4	0
ALOX12	V		V	V						V
CAMK2G		V		V
PPP1CC		V		V
PRKCB		V		V
PRKCH		V		V
CALM2		V		V
ASIC5							V
ADCY2							V
ADCY5							V
TRPA1							V
IL1R1									V
IL1RAP									V
IL1B									V	V	V
PIK3CD										V
CYP2J2										V
CYP4A11										V
CYP4A22										V
+ 5.8 Development and regeneration	1.8	0.7	1.9	1.1	2.3	3.1	1.2	0.2	4.8	3	4.8	0
+ 04360: Axon guidance	0.3	0.6	0.3	0.5	0.2	1.9	1.4	0.3	0.4	0.7	1.8	0
MYL9	V		V	V
PARD6A		V		V
RAC2		V		V						V	V
CDC42		V		V
ITGB1		V		V
SEMA4B		V		V
ILK		V		V	V
CAMK2G		V		V
MYL12B		V		V
MYL12A		V		V
PAK1					V
LIMK1					V
RHOA						V
EPHA3						V
EPHA7						V
EFNA5						V	V	V
WNT5A						V			V
GSK3B						V
DCC							V
ROBO1							V
UNC5D							V
ROBO2							V
SEMA3A							V
L1CAM								V
NRP1									V
GNAI2										V	V
GNAI3										V	V
RAC1										V	V
ABL1										V	V
PIK3CD										V
+ 04380: Osteoclast differentiation	2.3	0.3	2.4	1	2.9	2.5	0.3	0	6.4	3.5	5	0
TYROBP	V		V	V
SOCS1	V		V	V
CYBA	V		V	V						V	V
NCF4	V		V	V						V	V
TAB1		V		V
NFATC1		V		V
IFNG		V		V					V	V	V
JUNB		V		V
TGFBR1		V		V
FCGR1A					V
BTK					V
SOCS3					V
NFKB2					V
LILRB2					V
LILRA3					V
OSCAR					V
SIRPB1					V
SIRPA					V
CYLD						V
IFNB1						V			V
STAT1						V
JUN						V
SYK						V
TREM2						V			V
TNFRSF11A							V
TEC							V
TNFSF11									V
CSF1									V
TNFRSF11B									V
IL1A									V
IL1B									V	V	V
IL1R1									V
TNF									V	V	V
TNFRSF1A									V
TGFB1									V	V	V
TGFB2									V
LILRB1									V
LILRA2									V
NFKB1										V	V
PIK3CD										V
RAC1										V	V
NOX1										V	V
NCF2										V	V
NCF1										V	V
+ 5.9 Aging	1.1	0.7	0	0.9	1.1	1.9	1.8	1.5	1.1	6.1	6.9	0
+ 04211: Longevity regulating pathway	0.6	0.1	0	0.1	0.1	0.9	1.1	0.9	1	4.3	4.8	0
PRKAG2	V			V
ATF4		V		V
APPL1		V		V
CAT					V					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
ADCY2							V
ADCY5							V
PRKAB2							V	V
INS									V	V	V
ADIPOQ									V
PIK3CD										V
PRKAG3										V	V
INSR										V	V
TP53										V	V
SIRT1										V	V
PPARGC1A										V	V
NFKB1										V	V
EHMT2										V
+ 04213: Longevity regulating pathway - multiple species	0.8	0.9	0	1.1	1.3	1.8	1.5	1.2	0.6	4.3	4.9	0
PRKAG2	V			V
EIF4EBP2		V		V
SOD1		V		V
HDAC1		V		V						V	V
HDAC2		V		V						V	V
HSPA1B					V
HSPA6					V
CAT					V					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
CRYAB						V
ADCY2							V
ADCY5							V
PRKAB2							V	V
INS									V	V	V
PIK3CD										V
INSR										V	V
PRKAG3										V	V
SIRT1										V	V
+ 5.10 Environmental adaptation	1.6	0.8	0.6	1.1	0.6	2.3	1.9	2.8	0	10.8	6.3	0
+ 04710: Circadian rhythm	1.2	0	0	0.2	0.7	1.8	0.7	2.6	0	3.7	4.8	0
PRKAG2	V			V
SKP1					V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
PRKAB2							V	V
PER1								V
ARNTL										V	V
NPAS2										V	V
CLOCK										V	V
PRKAG3										V	V
+ 04713: Circadian entrainment	0	0.2	0	0.1	0.1	0.3	2	1.4	0	0.9	1.6	0
CALM2		V		V
CAMK2G		V		V
PRKCB		V		V
GNG10					V
CACNA1D						V
PRKG2							V
MTNR1B							V
ADCY2							V
ADCY5							V
KCNJ3							V
GNG3								V
RYR2								V		V	V
PER1								V
NOS1										V
GNAI2										V	V
GNAI3										V	V
+ 04714: Thermogenesis	1.6	1.2	1.1	1.6	0.3	1.9	0.6	0.8	0	14.2	4.5	0
ACTB	V		V	V
PRKAG2	V			V
COX7B	V		V	V						V
NDUFB3	V		V	V						V
SMARCB1		V		V
SMARCE1		V		V
ACSL3		V		V
NDUFA11		V		V						V
UQCRHL		V		V
NDUFA6		V		V						V
NDUFA10		V		V						V
NDUFC1		V		V	V					V
NDUFS5		V		V						V
NDUFB11		V		V						V
UQCRB		V		V
UQCRH		V		V
COX7A2L		V		V						V
NDUFAF2		V		V						V	V
MGLL					V
MAP3K5					V
SDHD					V
KDM3B						V
KDM3A						V
PRKAA1						V				V	V
PRKAA2						V		V		V	V
NDUFS7						V				V
NDUFS2						V				V
NDUFA13						V				V
ADCY2							V
ADCY5							V
PRKG2							V
FGFR1							V
PRKAB2							V	V
UCP1								V
PRDM16								V
PPARGC1A										V	V
SIRT6										V	V
PRKAG3										V	V
NDUFC2-KCTD14										V
COX17										V
COX6B1										V
COX6C										V
COX7A1										V
COX7A2										V
COX8A										V
COX10										V
COX15										V
NDUFAF6										V	V
COX7B2										V
NDUFAF3										V	V
NDUFAF4										V	V
COX8C										V
NDUFA1										V
NDUFA2										V
NDUFA3										V
NDUFA4										V
NDUFA5										V
NDUFA7										V
NDUFA8										V
NDUFA9										V
NDUFAB1										V
NDUFB1										V
NDUFB2										V
NDUFB4										V
NDUFB5										V
NDUFB6										V
NDUFB7										V
NDUFB8										V
NDUFB9										V
NDUFB10										V
NDUFC2										V
NDUFS1										V
NDUFS3										V
NDUFV1										V
NDUFS4										V
NDUFS6										V
NDUFS8										V
NDUFV2										V
NDUFV3										V
NDUFAF1										V	V
NDUFAF7										V	V
COA1										V	V
NDUFA12										V
SDHA										V
NDUFAF5										V	V
COX4I2										V
+ 6. Human Diseases	2	2.5	2	2.5	4.8	5.7	3.9	2	12.4	10.7	9.1	4.4
+ 6.1 Cancer: overview	2.1	1.8	2.2	2	3.5	5.4	2.1	1.2	8.2	10.5	6.7	5.4
+ 05200: Pathways in cancer	0.1	0.4	0.1	0.2	1.5	1.9	1	1	10.8	2.7	4.2	1.8
PML	V		V	V
MAX	V	V	V	V
ITGB1		V		V
APPL1		V		V
TFG		V		V
TPM3		V		V
RASSF5		V		V
RAC2		V		V						V	V
RALBP1		V		V
CDC42		V		V
MYC		V		V
LEF1		V		V
PRKCB		V		V
TGFBR1		V		V
HDAC1		V		V						V	V
HDAC2		V		V						V	V
CCND3		V		V
CDKN2A		V		V
FLT3LG		V		V					V
F2R		V		V
NFE2L2		V		V
HMOX1		V		V						V
CALM2		V		V
CAMK2G		V		V
IFNG		V		V					V	V	V
FZD2					V
STAT5A					V
NFKB2					V
CEBPA					V
E2F2					V
BID					V
CSF3R					V				V
GNG10					V
MGST1					V
GSTO1					V
BAK1					V
FRAT2					V
SKP1					V
CASP7					V
EPOR					V
IL12RB1					V
IL15RA					V				V
WNT5A						V			V
WNT3A						V			V
HGF						V	V
GSK3B						V
STAT1						V
RASSF1						V
RHOA						V
JUN						V
FGF3						V
FGF8						V
SP1						V
IL12B						V	V		V
IL23A						V			V
DCC							V
LAMB4							V
PDGFRA							V
FGFR1							V
APC							V
GLI3							V
PTGER3							V	V
ADCY2							V
ADCY5							V
ESR2							V	V
IFNA10							V	V
COL4A5								V
FGFR2								V
PAX8								V
RUNX1T1								V
FGF18								V
GNG3								V
WNT1									V
WNT2									V
WNT7A									V
FN1									V
LAMA5									V
EGFR									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
BMP4									V
VEGFA									V
MMP1									V			V
MMP2									V
MMP9									V			V
CXCL8									V
CSF2RA									V
IL6									V
FASLG									V
KITLG									V
FGF2									V
EPO									V
IFNA2									V
IFNA5									V
IFNA8									V
IFNA14									V
IFNA21									V
IL2									V
IL3									V
IL4									V
IL5									V
IL7									V
IL12A									V
IL13									V	V	V
IL15									V
IL4R									V
IL6R									V
IL6ST									V
IL7R									V
F2									V
EDN1									V
AGT									V	V	V
ABL1										V	V
BCR										V	V
PIK3CD										V
PDGFB										V	V
NFKB1										V	V
RAC1										V	V
TP53										V	V
CTBP1										V	V
CTBP2										V	V
BMP2										V	V
PTGS2										V
NOS2										V
AGTR1										V	V
GNAI2										V	V
GNAI3										V	V
NQO1										V
TXNRD2										V
TXNRD3										V
TXNRD1										V
+ 05202: Transcriptional misregulation in cancer	2.9	1	3	1.8	2.5	1.9	1	1.1	2.5	0.7	1.8	1.4
CEBPB	V		V	V
PML	V		V	V
CD40	V		V	V
ITGB7	V		V	V
MAX	V	V	V	V
HHEX	V		V	V
ATF1		V		V
FUS		V		V
MYC		V		V
TCF3		V		V
KLF3		V		V
BMI1		V		V
HPGD		V		V						V	V
TAF15		V		V
HDAC1		V		V						V	V
HDAC2		V		V						V	V
ASPSCR1					V
PRCC					V
BCL2A1					V
CEBPA					V
FCGR1A					V
REL					V
ETV7					V		V
MPO					V					V
CDKN2C					V
BAK1					V
PAX3						V
MEF2C						V
JMJD1C						V
KDM6A						V
UTY						V
SP1						V
ERG							V
ETV1							V	V
MEN1							V
SIX1							V
PAX8								V
MMP3								V	V
RUNX1T1								V
IL6									V
CXCL8									V
MMP9									V			V
IL1R2									V
IL3									V
CSF2									V
TP53										V	V
NFKB1										V	V
+ 05206: MicroRNAs in cancer	0.4	0.7	0.4	0.7	0.2	0.8	0.9	0.1	2.4	2.4	3	1.5
SOCS1	V		V	V
HMOX1		V		V						V
MYC		V		V
BMI1		V		V
CD44		V		V
HDAC1		V		V						V	V
UBE2I		V		V
PRKCB		V		V
CDKN2A		V		V
BAK1					V
E2F2					V
RASSF1						V
WNT3A						V			V
RHOA						V
ERBB3							V
APC							V
PDGFRA							V
SHC4							V
TNN								V
VEGFA									V
MMP9									V			V
EGFR									V
TGFB2									V
THBS1									V
HDAC4										V	V
ABL1										V	V
SIRT1										V	V
GLS										V
NFKB1										V	V
PTGS2										V
TP53										V	V
PDGFB										V	V
+ 05205: Proteoglycans in cancer	0.2	0.6	0.3	0.5	1	2.9	1.2	0.3	6.3	0.3	1.2	3.4
ACTB	V		V	V
CD44		V		V
PPP1CC		V		V
CAMK2G		V		V
CDC42		V		V
NUDT16L1		V		V
PXN		V		V
MYC		V		V
ITGB1		V		V
MSN		V		V
PRKCB		V		V
PAK1					V
PLAUR					V
HPSE					V
FZD2					V
CTSL					V
CD63					V
RHOA						V
ANK1						V
ANK2						V
TLR2						V						V
TLR4						V						V
IL12B						V	V		V
HGF						V	V
WNT5A						V			V
WNT3A						V			V
GAB1							V
ERBB3							V
FGFR1							V
KDR							V	V
PLCE1								V
MMP9									V			V
TGFB1									V	V	V
THBS1									V
MMP2									V
VEGFA									V
TNF									V	V	V
FASLG									V
TGFB2									V
SDC1									V
WNT1									V
FGF2									V
FN1									V
EGFR									V
WNT2									V
WNT7A									V
PIK3CD										V
RAC1										V	V
TP53										V	V
+ 05204: Chemical carcinogenesis	0	0	0	0	0.6	0.9	0.7	0.4	0	7.9	0	3
MGST1					V
GSTO1					V
KYAT3						V
CHRNA7						V
UGT1A6							V
SULT2A1							V	V
CYP1A1										V
CYP1A2										V
CYP2E1										V		V
ALDH3A1										V
ALDH1A3										V
ALDH3B1										V
ADH1A										V
ADH1B										V
ADH1C										V
ADH4										V
ADH5										V
ADH6										V
ADH7										V
CYP3A4										V
CYP2C19										V
CYP2C8										V
CYP2C9										V
HSD11B1										V
AKR1C2										V
CBR1										V
CYP2A6										V
PTGS2										V
NAT2												V
+ 05203: Viral carcinogenesis	1.2	2	1.3	2.1	2.3	2.1	0	0	0.7	3.5	5.5	0
YWHAH	V		V	V
YWHAZ	V	V	V	V
HIST1H2BD	V		V	V
PXN		V		V
DDB1		V		V
ATF4		V		V
CDKN2A		V		V
MAD1L1		V		V
RANBP1		V		V
USP7		V		V
CCND3		V		V
YWHAQ		V		V
SND1		V		V
GTF2B		V		V
HDAC1		V		V						V	V
HDAC2		V		V						V	V
CDC42		V		V
MAPKAPK2		V		V
BAK1					V
STAT5A					V
NFKB2					V
REL					V
EGR2					V	V
KAT2B					V					V	V
VDAC3					V
YWHAE					V	V
IRF7					V
HIST2H2BE					V
PSMC1						V
JUN						V
SYK						V
RHOA						V
C3						V
HIST1H2BA							V
IL6ST									V
HLA-E									V
HLA-G									V
TP53										V	V
PIK3CD										V
NFKB1										V	V
KAT2A										V	V
HDAC6										V	V
HDAC5										V	V
HDAC7										V	V
HDAC8										V	V
HDAC11										V	V
HDAC3										V	V
HDAC9										V	V
HDAC4										V	V
RAC1										V	V
+ 05230: Central carbon metabolism in cancer	0.8	0	0.8	0.1	2.3	0.5	0.8	0.5	0.5	8.7	1.9	0
SLC16A3	V		V	V	V
MYC		V		V
HK1					V
HK3					V
SLC1A5					V
IDH1					V	V				V
FGFR1							V
PDGFRA							V
FGFR2								V
EGFR									V
GCK										V
GLS										V
SIRT6										V	V
PDHA1										V
PDHA2										V
PDHB										V
SIRT3										V	V
LDHAL6A										V
LDHA										V
LDHB										V
LDHC										V
LDHAL6B										V
PIK3CD										V
HK2										V
PGAM4										V
PGAM1										V
PGAM2										V
TIGAR										V
TP53										V	V
PFKL										V
PFKM										V
G6PD										V
+ 05231: Choline metabolism in cancer	0	0.2	0	0.1	0.1	0.8	0.5	0.3	0.3	4.8	1.5	0
LYPLA1		V		V
RAC2		V		V						V	V
PRKCB		V		V
SLC44A1					V
SP1						V
JUN						V
PDGFRA							V
PIP5K1A							V	V
EGFR									V
PIK3CD										V
PDGFB										V	V
DGKK										V
DGKA										V
DGKB										V
DGKG										V
DGKH										V
DGKQ										V
DGKZ										V
DGKE										V
DGKD										V
DGKI										V
RAC1										V	V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	0.6	0.4	0.7	0.5	0.1	4.4	0.2	0	1	0.6	1	4.9
BATF	V		V	V
NFATC1		V		V
IFNG		V		V					V	V	V
CSNK2A3		V		V
LAT		V		V
BATF2					V		V
JUN						V
ZAP70						V
CD3E						V
STAT1						V
TLR9						V						V
TLR2						V						V
TLR4						V						V
CD28						V
CD4						V
EGFR									V
NFKB1										V	V
PIK3CD										V
TIRAP												V
+ 6.2 Cancer: specific types	0.7	2	0.7	1.7	3.4	3.5	2.3	1.1	9	4.8	6	1.3
+ 05210: Colorectal cancer	0	0.8	0	0.6	0.2	1.5	1.1	0.4	2.7	1.5	2.3	0
APPL1		V		V
TGFBR1		V		V
RAC2		V		V						V	V
MYC		V		V
LEF1		V		V
BAK1					V
RHOA						V
JUN						V
GSK3B						V
DCC							V
APC							V
EREG							V	V	V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
EGFR									V
PIK3CD										V
RAC1										V	V
TP53										V	V
+ 05212: Pancreatic cancer	0	1	0	0.8	0.6	0.4	0	0	2.9	2.2	3	0
RAC2		V		V						V	V
RALBP1		V		V
CDKN2A		V		V
CDC42		V		V
TGFBR1		V		V
E2F2					V
BAK1					V
STAT1						V
VEGFA									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
EGFR									V
PIK3CD										V
RAC1										V	V
NFKB1										V	V
TP53										V	V
+ 05225: Hepatocellular carcinoma	0.3	1	0.4	0.9	1.3	1.2	0.7	0	3.5	1.5	0.5	0
ACTB	V		V	V
MYC		V		V
LEF1		V		V
PRKCB		V		V
TGFBR1		V		V
SMARCB1		V		V
NFE2L2		V		V
HMOX1		V		V						V
CDKN2A		V		V
PHF10		V		V
SMARCE1		V		V
FRAT2					V
FZD2					V
E2F2					V
BAK1					V
MGST1					V
GSTO1					V
GSK3B						V
WNT5A						V			V
WNT3A						V			V
HGF						V	V
SHC4							V
APC							V
GAB1							V
EGFR									V
WNT1									V
WNT2									V
WNT7A									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
PIK3CD										V
TP53										V	V
NQO1										V
TXNRD2										V
TXNRD3										V
TXNRD1										V
+ 05226: Gastric cancer	0	0	0	0	0.7	2.2	0.9	0.5	4.2	0.2	0.6	0
MYC		V		V
LEF1		V		V
TGFBR1		V		V
FRAT2					V
FZD2					V
BAK1					V
E2F2					V
GSK3B						V
WNT5A						V			V
WNT3A						V			V
HGF						V	V
FGF3						V
FGF8						V
SHC4							V
APC							V
GAB1							V
FGFR2								V
FGF18								V
WNT1									V
WNT2									V
WNT7A									V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
FGF2									V
EGFR									V
PIK3CD										V
TP53										V	V
+ 05214: Glioma	0	0.7	0	0.5	0.6	0	0.7	0	0.5	1.3	1.8	0
CALM2		V		V
CAMK2G		V		V
PRKCB		V		V
CDKN2A		V		V
E2F2					V
BAK1					V
PDGFRA							V
SHC4							V
EGFR									V
PDGFB										V	V
CAMK1D										V	V
PIK3CD										V
TP53										V	V
+ 05216: Thyroid cancer	0	1.6	0	1.4	0.5	0	0	0.8	0	0.4	0.9	0
MYC		V		V
TFG		V		V
TPM3		V		V
LEF1		V		V
BAK1					V
PAX8								V
TP53										V	V
+ 05221: Acute myeloid leukemia	0.8	0.2	0.8	0.3	2.3	0	0	0.5	1.2	1	0.6	0
PML	V		V	V
MYC		V		V
LEF1		V		V
CEBPA					V
STAT5A					V
BCL2A1					V
FCGR1A					V
MPO					V					V
RUNX1T1								V
CSF2									V
IL3									V
NFKB1										V	V
PIK3CD										V
+ 05220: Chronic myeloid leukemia	0	1	0	0.8	1.1	0	0.3	0	1.7	3.9	5.1	0
HDAC1		V		V						V	V
HDAC2		V		V						V	V
MYC		V		V
TGFBR1		V		V
CDKN2A		V		V
STAT5A					V
E2F2					V
BAK1					V
SHC4							V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
ABL1										V	V
BCR										V	V
TP53										V	V
CTBP1										V	V
CTBP2										V	V
NFKB1										V	V
PIK3CD										V
+ 05217: Basal cell carcinoma	0	0.1	0	0	0.8	1.8	0.9	0	3.7	0.6	1.3	0
LEF1		V		V
FZD2					V
BAK1					V
WNT5A						V			V
WNT3A						V			V
GSK3B						V
APC							V
GLI3							V
BMP4									V
WNT1									V
WNT2									V
WNT7A									V
BMP2										V	V
TP53										V	V
+ 05218: Melanoma	0	0	0	0	0.7	1.7	1.3	0.5	1.1	0.9	1.2	0
CDKN2A		V		V
E2F2					V
BAK1					V
FGF3						V
FGF8						V
HGF						V	V
FGFR1							V
PDGFRA							V
FGF18								V
EGFR									V
FGF2									V
PDGFB										V	V
TP53										V	V
PIK3CD										V
+ 05211: Renal cell carcinoma	0	0	0	0	0.7	1.1	0.8	0	2.5	1.4	1.9	0
CDC42		V		V
PAK1					V
PRCC					V
JUN						V
HGF						V	V
GAB1							V
TGFB1									V	V	V
TGFB2									V
TGFB3									V
VEGFA									V
PDGFB										V	V
RAC1										V	V
PIK3CD										V
+ 05219: Bladder cancer	1.1	0.5	1.1	0.8	0.5	0.7	0	0	4.9	0.4	0.8	3.4
TYMP	V		V	V
CDKN2A		V		V
MYC		V		V
E2F2					V
RASSF1						V
MMP1									V			V
MMP2									V
MMP9									V			V
VEGFA									V
CXCL8									V
THBS1									V
EGFR									V
TP53										V	V
+ 05215: Prostate cancer	0	0.1	0	0	0.1	0.3	1	0.8	2.6	1.8	2.1	1.7
LEF1		V		V
ATF4		V		V
E2F2					V
GSK3B						V
FGFR1							V
PDGFRA							V
ERG							V
FGFR2								V
MMP3								V	V
EGFR									V
INS									V	V	V
MMP9									V			V
IL1R2									V
SRD5A2										V
NFKB1										V	V
TP53										V	V
PDGFB										V	V
PIK3CD										V
+ 05213: Endometrial cancer	0	0.6	0	0.4	0.8	0.5	0.4	0	0.6	0.6	0.7	0
ILK		V		V	V
LEF1		V		V
MYC		V		V
BAK1					V
GSK3B						V
APC							V
EGFR									V
PIK3CD										V
TP53										V	V
+ 05224: Breast cancer	0	0	0	0	1.1	2.7	1.3	0.5	3.3	0.1	0.2	0
MYC		V		V
LEF1		V		V
FRAT2					V
FZD2					V
E2F2					V
NFKB2					V
BAK1					V
JUN						V
SP1						V
GSK3B						V
WNT5A						V			V
WNT3A						V			V
FGF3						V
FGF8						V
ESR2							V	V
SHC4							V
PGR							V
APC							V
FGFR1							V
FGF18								V
EGFR									V
WNT1									V
WNT2									V
WNT7A									V
TNFSF11									V
FGF2									V
PIK3CD										V
TP53										V	V
+ 05222: Small cell lung cancer	0.6	0.2	0.7	0.1	0.5	0	0.2	0.3	0.9	1.4	1	0
MAX	V	V	V	V
ITGB1		V		V
MYC		V		V
E2F2					V
BAK1					V
LAMB4							V
COL4A5								V
FN1									V
LAMA5									V
PIK3CD										V
NOS2										V
PTGS2										V
NFKB1										V	V
TP53										V	V
+ 05223: Non-small cell lung cancer	0	0.5	0	0.3	1.3	0.5	0	0	0.5	0.5	0.6	0
PRKCB		V		V
RASSF5		V		V
CDKN2A		V		V
E2F2					V
STAT5A					V
BAK1					V
RASSF1						V
EGFR									V
PIK3CD										V
TP53										V	V
+ 6.12 Drug resistance: antineoplastic	0.6	0.5	0.6	0.6	1.5	0.9	2.3	1.1	4.3	3.2	3.1	0.9
+ 01521: EGFR tyrosine kinase inhibitor resistance	0	0	0	0	0	1	3.2	1	3.9	0.4	0.5	0
PRKCB		V		V
GSK3B						V
HGF						V	V
ERBB3							V
GAB1							V
SHC4							V
PDGFRA							V
KDR							V	V
NRG2							V
FGFR2								V
EGFR									V
VEGFA									V
FGF2									V
GAS6									V
IL6									V
IL6R									V
NRG1									V
PIK3CD										V
PDGFB										V	V
+ 01524: Platinum drug resistance	0	0.1	0	0.1	2.7	0	0	0	0.5	0.9	1.2	0
ERCC1		V		V
CDKN2A		V		V
BID					V
BAK1					V
SLC31A1					V
MGST1					V
GSTO1					V
MAP3K5					V
FASLG									V
TP53										V	V
ATP7A										V	V
PIK3CD										V
+ 01523: Antifolate resistance	1.2	0.8	1.3	1.2	0	0	0	0.9	2.7	4.2	3.5	0
ALOX12	V		V	V						V
GART		V		V
SHMT2		V		V
ABCC4								V		V	V
IL6									V
IL1B									V	V	V
TNF									V	V	V
DHFR										V
NFKB1										V	V
MTHFR										V
+ 01522: Endocrine resistance	0	0	0	0	0.4	0.8	1.5	0.3	1.5	0.9	1	1.7
CDKN2A		V		V
CDKN2C					V
E2F2					V
JUN						V
SP1						V
ESR2							V	V
SHC4							V
ADCY2							V
ADCY5							V
MMP2									V
MMP9									V			V
EGFR									V
PIK3CD										V
TP53										V	V
CYP2D6										V
ABCB11										V	V

**Save / Export**
META-Z-score:	download
Z-score:	download
Genes in pathway/subsystem/system:	download