Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	B4 high&S&CNA	B4 high&S	B4 low&S	Smoker (S)	NonSmoker (NS)
	88/222	415/994	370/885	391/931	437/1021
+ 1. Metabolism	2.3	7	8	8.6	10.4
+ 1.0 Global and overview maps	0.6	2.1	2.4	2.4	3.1
+ 01100: Metabolic pathways	0.3	1.4	2.4	2.6	4
EHHADH	V
PLD1	V
PIK3CA	V
B3GALNT1	V
SI	V
PCYT1A	V
DGKG	V
MCCC1	V
BDH1	V
ST6GAL1	V
B3GNT5	V
ALG3	V
PIGX	V
NDUFB5	V
FADS2		V
FADS1		V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
GGT6		V	V	V	V
GPX3		V	V	V	V
ALDH3A1		V		V	V
PIK3C2G		V		V	V
MAOB		V	V	V	V
ASPA		V	V	V	V
NOS1		V	V	V	V
SDS		V
UGT1A8		V	V	V	V
ENPP3		V	V	V	V
PDE4C		V	V	V	V
ADCY2		V	V	V	V
PDE6A		V	V	V	V
GUCY2C		V		V	V
CA3		V	V	V	V
CA6		V	V	V	V
CA9		V	V	V	V
LDHD		V	V	V	V
FUT6		V	V	V	V
ST6GALNAC1		V	V	V	V
AMY1A		V	V	V	V
CHST9		V	V	V	V
CHIT1		V		V	V
CYP2C18		V
CYP3A4		V	V	V	V
CYP3A5		V	V	V	V
HMGCS2		V	V	V	V
CBS		V	V	V
TDO2		V	V	V	V
RGN		V	V	V	V
DNMT3B		V	V	V	V
CKM		V	V	V	V
CKMT2		V	V	V	V
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
AOX1		V	V	V	V
ACADL		V	V	V	V
TM7SF2		V		V	V
ACOX2		V		V	V
CYP11A1		V	V	V	V
CYP21A2		V	V	V	V
HSD17B6		V	V	V	V
CYP27B1		V	V	V	V
FBP2		V	V	V	V
GPT		V	V	V	V
PLA2G2A		V	V	V	V
PLA2G7		V	V	V	V
DEGS2		V		V	V
ACER1		V	V	V	V
CYP2J2		V		V	V
EPHX2		V	V	V
PTGDS		V			V
CYP2E1		V	V	V	V
GALNT5		V	V	V	V
GALNT16		V	V	V	V
B3GALT5		V	V	V	V
B4GALNT1		V	V	V
PGAM2		V	V	V	V
ENO2		V	V	V	V
ENO3		V	V	V	V
DCT		V	V	V	V
PCK1		V	V	V	V
EXTL1		V	V	V	V
ALDH1A1		V	V	V	V
TREH		V	V	V	V
NMRK2		V		V
B3GNT6		V	V	V	V
GCNT3		V	V	V	V
GYS2		V	V	V	V
PYGM		V	V	V	V
AMPD1		V	V	V	V
P4HA3		V	V	V	V
COX6A2		V	V	V	V
COX7A1		V	V	V	V
ATP6V0D2		V
ATP6V0A4		V	V	V	V
HKDC1			V	V
GATM			V	V	V
GAD1			V
UGT1A7			V	V	V
NT5C1A			V	V
ENPP4			V	V	V
PDE11A			V		V
MIOX			V
ACACB			V		V
ALPP			V		V
ALOX12			V	V	V
ALOX15			V		V
MGLL			V	V	V
ABO			V	V	V
ACSM3			V	V	V
ALDH1A2			V	V	V
UGT1A10				V	V
GSTA2					V
GSTM5					V
PLCB4					V
UGT1A6					V
UGT1A9					V
ADCY5					V
CA13					V
CA4					V
CA8					V
CYP1A1					V
CHDH					V
TYRP1					V
IDO1					V
CDO1					V
ADH7					V
GPT2					V
PLA2G2F					V
PTGIS					V
GALNT12					V
RDH16					V
ACSS3					V
ATP12A					V
+ 01200: Carbon metabolism	0.3	0.8	1.1	1	0.8
EHHADH	V
PGAM2		V	V	V	V
FBP2		V	V	V	V
ENO2		V	V	V	V
ENO3		V	V	V	V
SDS		V
RGN		V	V	V	V
GPT		V	V	V	V
HKDC1			V	V
GPT2					V
+ 01210: 2-Oxocarboxylic acid metabolism	0	0.5	0.6	0.5	1.2
GPT		V	V	V	V
GPT2					V
+ 01212: Fatty acid metabolism	0.7	0.6	0.3	0.3	0.1
EHHADH	V
FADS2		V
FADS1		V	V	V
ACADL		V	V	V	V
+ 01230: Biosynthesis of amino acids	0	1.3	1.1	1	0.9
PGAM2		V	V	V	V
ENO2		V	V	V	V
ENO3		V	V	V	V
SDS		V
GPT		V	V	V	V
CBS		V	V	V
GPT2					V
+ 1.1 Carbohydrate metabolism	1.5	2.2	3.7	3.6	3.8
+ 00010: Glycolysis / Gluconeogenesis	0	3.1	2.9	3.6	3.4
ALDH3A1		V		V	V
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
ENO2		V	V	V	V
ENO3		V	V	V	V
PGAM2		V	V	V	V
FBP2		V	V	V	V
PCK1		V	V	V	V
HKDC1			V	V
ADH7					V
+ 00020: Citrate cycle (TCA cycle)	0	0.3	0.3	0.3	0.2
PCK1		V	V	V	V
+ 00030: Pentose phosphate pathway	0	0.7	0.8	0.8	0.7
FBP2		V	V	V	V
RGN		V	V	V	V
+ 00040: Pentose and glucuronate interconversions	0	0.2	0.7	1.2	2.1
UGT1A8		V	V	V	V
UGT1A7			V	V	V
UGT1A10				V	V
UGT1A6					V
UGT1A9					V
+ 00051: Fructose and mannose metabolism	0	0.2	0.8	0.7	0.2
FBP2		V	V	V	V
HKDC1			V	V
+ 00052: Galactose metabolism	1	0	0.3	0.3	0
SI	V
HKDC1			V	V
+ 00053: Ascorbate and aldarate metabolism	0	0.8	2.1	2.1	3
RGN		V	V	V	V
UGT1A8		V	V	V	V
MIOX			V
UGT1A7			V	V	V
UGT1A10				V	V
UGT1A6					V
UGT1A9					V
+ 00500: Starch and sucrose metabolism	1	2.1	2.8	2.7	2.1
SI	V
ENPP3		V	V	V	V
GYS2		V	V	V	V
TREH		V	V	V	V
AMY1A		V	V	V	V
PYGM		V	V	V	V
HKDC1			V	V
+ 00520: Amino sugar and nucleotide sugar metabolism	0	0.1	0.1	0.4	0.1
CHIT1		V		V	V
HKDC1			V	V
+ 00620: Pyruvate metabolism	0	0.5	1.1	0.6	1
PCK1		V	V	V	V
LDHD		V	V	V	V
ACACB			V		V
+ 00630: Glyoxylate and dicarboxylate metabolism	0	0	0	0	0
+ 00640: Propanoate metabolism	1	0	0.3	0	0.6
EHHADH	V
ACACB			V		V
ACSS3					V
+ 00650: Butanoate metabolism	2	0.3	1.5	0.9	0.8
BDH1	V
EHHADH	V
HMGCS2		V	V	V	V
GAD1			V
ACSM3			V	V	V
+ 00562: Inositol phosphate metabolism	0.6	0	0	0	0.1
PIK3CA	V
PIK3C2G		V		V	V
MIOX			V
PLCB4					V
+ 1.2 Energy metabolism	0.2	1.6	1.7	1.7	2.7
+ 00190: Oxidative phosphorylation	0.3	0.1	0.1	0.1	0.1
NDUFB5	V
COX7A1		V	V	V	V
COX6A2		V	V	V	V
ATP6V0D2		V
ATP6V0A4		V	V	V	V
ATP12A					V
+ 00910: Nitrogen metabolism	0	1.9	2	2	3.8
CA3		V	V	V	V
CA6		V	V	V	V
CA9		V	V	V	V
CA13					V
CA4					V
CA8					V
+ 00920: Sulfur metabolism	0	0.8	0.9	0.9	0.8
SELENBP1		V	V	V	V
+ 1.3 Lipid metabolism	1.4	3.7	3.2	3.7	4.9
+ 00061: Fatty acid biosynthesis	0	0	0.6	0	0.5
ACACB			V		V
+ 00062: Fatty acid elongation	0	0	0	0	0
+ 00071: Fatty acid degradation	0.8	1.8	1.5	1.9	2.2
EHHADH	V
ACADL		V	V	V	V
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
ADH7					V
+ 00072: Synthesis and degradation of ketone bodies	1.6	0.8	0.9	0.9	0.8
BDH1	V
HMGCS2		V	V	V	V
+ 00100: Steroid biosynthesis	0	1.1	0.5	1.2	1.1
TM7SF2		V		V	V
CYP27B1		V	V	V	V
+ 00120: Primary bile acid biosynthesis	0	1.2	0	0.6	1.2
ACOX2		V		V	V
CH25H		V			V
+ 00140: Steroid hormone biosynthesis	0	2.1	2.8	3.1	4
HSD17B6		V	V	V	V
CYP11A1		V	V	V	V
CYP21A2		V	V	V	V
CYP3A5		V	V	V	V
UGT1A8		V	V	V	V
CYP2E1		V	V	V	V
CYP3A4		V	V	V	V
UGT1A7			V	V	V
UGT1A10				V	V
CYP1A1					V
UGT1A6					V
UGT1A9					V
+ 00561: Glycerolipid metabolism	0.7	0	0.3	0.3	0.2
DGKG	V
PLPP4		V	V	V	V
MGLL			V	V	V
+ 00564: Glycerophospholipid metabolism	1.6	0.6	0.8	0.7	0.8
PCYT1A	V
DGKG	V
PLD1	V
PLA2G2A		V	V	V	V
PLPP4		V	V	V	V
GPD1L		V	V	V	V
GPD1		V	V	V	V
PNPLA7		V	V	V	V
PLA2G2F					V
+ 00565: Ether lipid metabolism	0.8	0.8	0.5	0.9	1.2
PLD1	V
PLA2G7		V	V	V	V
PLA2G2A		V	V	V	V
GDPD3		V		V	V
PLA2G2F					V
+ 00600: Sphingolipid metabolism	0	0.4	0.1	0.4	0.4
DEGS2		V		V	V
ACER1		V	V	V	V
+ 00590: Arachidonic acid metabolism	0	1.6	1.8	1.8	2.8
EPHX2		V	V	V
CYP2J2		V		V	V
GPX3		V	V	V	V
PLA2G2A		V	V	V	V
PTGDS		V			V
CYP2E1		V	V	V	V
ALOX12			V	V	V
ALOX15			V		V
PLA2G2F					V
PTGIS					V
+ 00591: Linoleic acid metabolism	0	1.9	2.1	2	3
PLA2G2A		V	V	V	V
CYP2J2		V		V	V
CYP2E1		V	V	V	V
CYP3A4		V	V	V	V
ALOX15			V		V
PLA2G2F					V
+ 00592: alpha-Linolenic acid metabolism	0	0.9	0.4	0.4	0.9
PLA2G2A		V	V	V	V
FADS2		V
PLA2G2F					V
+ 01040: Biosynthesis of unsaturated fatty acids	0	0.8	0.4	0.3	0
FADS2		V
FADS1		V	V	V
+ 1.4 Nucleotide metabolism	0	0.4	1.1	1	0.9
+ 00230: Purine metabolism	0	0.4	1.2	1.1	1.2
ADCY2		V	V	V	V
AMPD1		V	V	V	V
GUCY2C		V		V	V
PDE6A		V	V	V	V
PDE4C		V	V	V	V
ENPP3		V	V	V	V
PDE11A			V		V
NT5C1A			V	V
ENPP4			V	V	V
ADCY5					V
+ 00240: Pyrimidine metabolism	0	0.1	0.3	0.3	0.1
ENPP3		V	V	V	V
NT5C1A			V	V
+ 1.5 Amino acid metabolism	0.9	4	3.5	3.9	4.4
+ 00250: Alanine, aspartate and glutamate metabolism	0	0.6	1.2	0.6	1
GPT		V	V	V	V
ASPA		V	V	V	V
GAD1			V
GPT2					V
+ 00260: Glycine, serine and threonine metabolism	0	1.4	1.6	1.5	1.4
CBS		V	V	V
SDS		V
MAOB		V	V	V	V
PGAM2		V	V	V	V
GATM			V	V	V
CHDH					V
+ 00270: Cysteine and methionine metabolism	0	0.7	0.4	0.4	0.3
CBS		V	V	V
DNMT3B		V	V	V	V
SDS		V
CDO1					V
+ 00280: Valine, leucine and isoleucine degradation	1.6	0.4	0.4	0.4	0.3
MCCC1	V
EHHADH	V
HMGCS2		V	V	V	V
AOX1		V	V	V	V
+ 00290: Valine, leucine and isoleucine biosynthesis	0	1.3	0	0	0
SDS		V
+ 00310: Lysine degradation	0.7	0	0	0	0
EHHADH	V
+ 00220: Arginine biosynthesis	0	1	1.1	1.1	1.7
NOS1		V	V	V	V
GPT		V	V	V	V
GPT2					V
+ 00330: Arginine and proline metabolism	0	1.6	2.3	2.2	2
MAOB		V	V	V	V
CKM		V	V	V	V
CKMT2		V	V	V	V
NOS1		V	V	V	V
P4HA3		V	V	V	V
GATM			V	V	V
+ 00340: Histidine metabolism	0	1.6	1.1	1.7	1.6
MAOB		V	V	V	V
ALDH3A1		V		V	V
ASPA		V	V	V	V
+ 00350: Tyrosine metabolism	0	3.6	2.8	3.7	4.4
ALDH3A1		V		V	V
MAOB		V	V	V	V
AOX1		V	V	V	V
DCT		V	V	V	V
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
ADH7					V
TYRP1					V
+ 00360: Phenylalanine metabolism	0	1.3	0.6	1.3	1.3
ALDH3A1		V		V	V
MAOB		V	V	V	V
+ 00380: Tryptophan metabolism	0.9	0.9	1	1	1.8
EHHADH	V
MAOB		V	V	V	V
TDO2		V	V	V	V
AOX1		V	V	V	V
IDO1					V
CYP1A1					V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	0	0
+ 1.6 Metabolism of other amino acids	1.1	0.7	1	0.8	1.4
+ 00410: beta-Alanine metabolism	1	0.2	0.3	0.3	0.2
EHHADH	V
ALDH3A1		V		V	V
GAD1			V
+ 00430: Taurine and hypotaurine metabolism	0	0.8	1.7	0.8	1.6
GGT6		V	V	V	V
GAD1			V
CDO1					V
+ 00440: Phosphonate and phosphinate metabolism	1.8	0	0	0	0
PCYT1A	V
+ 00450: Selenocompound metabolism	0	0	0	0	0
+ 00471: D-Glutamine and D-glutamate metabolism	0	0	0	0	0
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0
+ 00480: Glutathione metabolism	0	1	0.7	1.1	1.8
GGT6		V	V	V	V
GPX3		V	V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
GSTA2					V
GSTM5					V
+ 1.7 Glycan biosynthesis and metabolism	2.4	1.6	1.8	1.8	1.6
+ 00510: N-Glycan biosynthesis	1.6	0	0	0	0
ALG3	V
ST6GAL1	V
+ 00512: Mucin type O-glycan biosynthesis	0	2.4	2.5	2.5	2.9
GCNT3		V	V	V	V
ST6GALNAC1		V	V	V	V
B3GNT6		V	V	V	V
GALNT5		V	V	V	V
GALNT16		V	V	V	V
GALNT12					V
+ 00515: Mannose type O-glycan biosynthesis	0	0	0	0	0
+ 00514: Other types of O-glycan biosynthesis	1.2	0	0	0	0
ST6GAL1	V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	0.5	0	0	0
CHST11		V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0	0.4	0.5	0.4	0.4
EXTL1		V	V	V	V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	0.6	0.7	0.7	0.6
CHST2		V	V	V	V
+ 00531: Glycosaminoglycan degradation	0	0	0	0	0
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2.2	0	0	0	0
PIGX	V
PIGZ	V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	2.1	0.9	1.6	1.5	1.4
B3GNT5	V
B3GALNT1	V
FUT6		V	V	V	V
B3GALT5		V	V	V	V
ABO			V	V	V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	1.4	0.6	0.7	0.6	0.6
B3GALNT1	V
B3GALT5		V	V	V	V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0	0.6	0.7	0.6	0
B4GALNT1		V	V	V
+ 00511: Other glycan degradation	0	0	0	0	0
+ 1.8 Metabolism of cofactors and vitamins	0	2.5	3.1	3.2	3.7
+ 00730: Thiamine metabolism	0	0	0.7	0	0.6
ALPP			V		V
+ 00740: Riboflavin metabolism	0	0.9	1	1	0.9
ENPP3		V	V	V	V
+ 00750: Vitamin B6 metabolism	0	1.1	1.2	1.1	1.1
AOX1		V	V	V	V
+ 00760: Nicotinate and nicotinamide metabolism	0	1.3	1.4	1.9	0.7
ENPP3		V	V	V	V
NMRK2		V		V
AOX1		V	V	V	V
NT5C1A			V	V
+ 00770: Pantothenate and CoA biosynthesis	0	0.5	0.5	0.5	0.5
ENPP3		V	V	V	V
+ 00780: Biotin metabolism	0	0	0	0	0
+ 00785: Lipoic acid metabolism	0	0	0	0	0
+ 00790: Folate biosynthesis	0	0	0.4	0	0.3
ALPP			V		V
+ 00670: One carbon pool by folate	0	0.4	0.5	0.5	0.4
ALDH1L1		V	V	V	V
+ 00830: Retinol metabolism	0	3.8	4.1	4.7	6.1
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
ALDH1A1		V	V	V	V
AOX1		V	V	V	V
LRAT		V
CYP3A4		V	V	V	V
CYP3A5		V	V	V	V
CYP2C18		V
UGT1A8		V	V	V	V
HSD17B6		V	V	V	V
ALDH1A2			V	V	V
UGT1A7			V	V	V
CYP27C1			V	V	V
UGT1A10				V	V
ADH7					V
CYP1A1					V
RDH16					V
UGT1A6					V
UGT1A9					V
+ 00860: Porphyrin and chlorophyll metabolism	0	0.5	1	1.5	2.3
UGT1A8		V	V	V	V
CP		V	V	V	V
UGT1A7			V	V	V
UGT1A10				V	V
UGT1A6					V
UGT1A9					V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0	0	0	0	0
+ 1.9 Metabolism of terpenoids and polyketides	0	0.4	0.4	0.4	0.4
+ 00900: Terpenoid backbone biosynthesis	0	0.4	0.4	0.4	0.4
HMGCS2		V	V	V	V
+ 1.10 Biosynthesis of other secondary metabolites	0	0	0.9	0.9	0
+ 00232: Caffeine metabolism	0	0	0	0	0
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	1.3	1.2	0
HKDC1			V	V
+ 1.11 Xenobiotics biodegradation and metabolism	0	5	4.9	6.5	9.2
+ 00980: Metabolism of xenobiotics by cytochrome P450	0	3.5	3.1	4.4	6.1
CYP2E1		V	V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
UGT1A8		V	V	V	V
ALDH3A1		V		V	V
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
CYP3A4		V	V	V	V
CYP3A5		V	V	V	V
CYP2F1		V	V	V	V
UGT1A7			V	V	V
UGT1A10				V	V
GSTA2					V
GSTM5					V
UGT1A6					V
UGT1A9					V
ADH7					V
CYP1A1					V
+ 00982: Drug metabolism - cytochrome P450	0	4.4	3.9	5.2	6.5
ALDH3A1		V		V	V
FMO2		V	V	V	V
CYP3A4		V	V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
UGT1A8		V	V	V	V
MAOB		V	V	V	V
AOX1		V	V	V	V
CYP2E1		V	V	V	V
CYP3A5		V	V	V	V
UGT1A7			V	V	V
UGT1A10				V	V
GSTA2					V
GSTM5					V
ADH7					V
UGT1A6					V
UGT1A9					V
+ 00983: Drug metabolism - other enzymes	0	0.9	1.4	1.7	3.3
UGT1A8		V	V	V	V
CYP3A4		V	V	V	V
CYP2E1		V	V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
CES1			V		V
UGT1A7			V	V	V
UGT1A10				V	V
UGT1A6					V
UGT1A9					V
GSTA2					V
GSTM5					V
+ 2. Genetic Information Processing	3.2	0.2	0.2	0.2	0
+ 2.1 Transcription	1.3	0	0	0	0
+ 03020: RNA polymerase	1	0	0	0	0
POLR2H	V
+ 03022: Basal transcription factors	0	0	0	0	0
+ 03040: Spliceosome	1.3	0	0	0	0
NCBP2	V
HNRNPA3	V
TRA2B	V
+ 2.2 Translation	2.4	0	0	0	0
+ 03010: Ribosome	0.7	0	0	0	0
RPL35A	V
RPL22L1	V
+ 00970: Aminoacyl-tRNA biosynthesis	0	0	0	0	0
+ 03013: RNA transport	3	0	0	0	0
NCBP2	V
SENP2	V
NMD3	V
EIF4A2	V
EIF4G1	V
EIF2B5	V
FXR1	V
EEF1A2		V	V	V	V
+ 03015: mRNA surveillance pathway	0.5	0	0	0	0
NCBP2	V
+ 03008: Ribosome biogenesis in eukaryotes	1.2	0	0	0	0
NMD3	V
LSG1	V
+ 2.3 Folding, sorting and degradation	1.2	0.1	0.1	0.1	0
+ 03060: Protein export	1.2	0	0	0	0
SEC62	V
+ 04141: Protein processing in endoplasmic reticulum	1.1	0	0	0	0
SEC62	V
DNAJB11	V
NFE2L2	V
PRKN		V	V	V	V
CRYAB		V	V	V	V
SVIP					V
+ 04130: SNARE interactions in vesicular transport	0	0.2	0	0	0
STX19		V
+ 04120: Ubiquitin mediated proteolysis	0	0	0.2	0	0
PRKN		V	V	V	V
UBE2C		V	V	V	V
SOCS1			V
CDC20			V
+ 04122: Sulfur relay system	0	0	0	0	0
+ 03050: Proteasome	0.8	0	0	0	0
PSMD2	V
+ 03018: RNA degradation	0	0.1	0.2	0.1	0.1
ENO2		V	V	V	V
ENO3		V	V	V	V
+ 2.4 Replication and repair	1.4	0.2	0.3	0.3	0
+ 03030: DNA replication	1	0	0	0	0
RFC4	V
+ 03410: Base excision repair	0	0	0	0	0
+ 03420: Nucleotide excision repair	0.8	0	0	0	0
RFC4	V
+ 03430: Mismatch repair	1.2	0.4	0.4	0.4	0
RFC4	V
EXO1		V	V	V
+ 03440: Homologous recombination	0	0.1	0.2	0.2	0
EME1		V	V	V
+ 03450: Non-homologous end-joining	0	0	0	0	0
+ 03460: Fanconi anemia pathway	0.7	0.1	0.1	0.1	0
HES1	V
EME1		V	V	V
+ 3. Environmental Information Processing	3.2	6.2	6.5	6.6	6.1
+ 3.1 Membrane transport	0.8	0.8	1	0.9	0.8
+ 02010: ABC transporters	0.8	0.8	1	0.9	0.8
ABCC5	V
CFTR		V	V	V	V
ABCA8		V	V	V	V
DEFB1		V	V	V	V
+ 3.2 Signal transduction	3.8	4	4.5	4.4	4.9
+ 04010: MAPK signaling pathway	0.8	0.2	0.1	0.1	0.2
MAP3K13	V
IL1RAP	V
PAK2	V
MECOM	V
DUSP9		V	V	V	V
MAPT		V	V	V	V
ERBB4		V	V	V	V
CACNG6		V	V	V	V
CACNA1B		V		V
CACNA1S		V	V	V	V
CACNB4		V	V	V	V
CACNG1		V
RPS6KA6		V	V	V	V
NTF3		V		V	V
PGF		V
FGF19		V
IL1A			V	V
FOS			V
EGF					V
FGF7					V
VEGFD					V
IGF1					V
+ 04012: ErbB signaling pathway	1.1	0.2	0.9	0.5	1
PAK2	V
PIK3CA	V
ERBB4		V	V	V	V
NRG2		V	V	V	V
CAMK2B		V	V	V	V
NRG1			V
BTC			V	V	V
PAK5					V
EGF					V
+ 04014: Ras signaling pathway	1.1	0	0	0	0.4
PIK3CA	V
PLD1	V
GNB4	V
PAK2	V
NTF3		V		V	V
PGF		V
FGF19		V
PLA2G2A		V	V	V	V
GNGT1		V
HTR7		V		V	V
CALML6			V	V	V
EGF					V
FGF7					V
VEGFD					V
IGF1					V
PLA2G2F					V
GNG7					V
PAK5					V
+ 04015: Rap1 signaling pathway	0.4	0	0	0	0.2
PIK3CA	V
PRKCI	V
PGF		V
FGF19		V
ADCY2		V	V	V	V
CALML6			V	V	V
EGF					V
FGF7					V
VEGFD					V
IGF1					V
PLCB4					V
ADCY5					V
+ 04310: Wnt signaling pathway	1.1	1.3	1	1.4	1.7
DVL3	V
TBL1XR1	V
SENP2	V
CAMK2B		V	V	V	V
FZD2		V		V	V
MMP7		V		V
DKK4		V	V	V	V
WIF1		V	V	V	V
SFRP1		V	V	V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
SOST		V	V	V	V
CCN4		V	V	V	V
ROR2		V
NOTUM			V	V
PLCB4					V
SFRP5					V
LGR6					V
RSPO1					V
+ 04330: Notch signaling pathway	1.6	0.4	0.4	0.4	0
HES1	V
DVL3	V
KAT2B		V	V	V
DLL3		V		V
MAML3			V
+ 04340: Hedgehog signaling pathway	0	0.1	0.1	0.1	0
BOC		V	V	V
+ 04350: TGF-beta signaling pathway	0.4	1.2	1.5	1.4	1.2
CHRD	V
ID4		V	V	V	V
INHBA		V	V	V	V
FST		V	V	V	V
BMP8A		V	V	V	V
HJV		V	V	V	V
GREM1		V	V	V	V
GREM2		V	V	V	V
+ 04390: Hippo signaling pathway	1.6	0.6	0.6	0.7	0.6
DLG1	V
PRKCI	V
DVL3	V
SOX2	V
BIRC5		V	V	V	V
AMOT		V	V	V	V
DLG2		V	V	V	V
SERPINE1		V	V	V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
FZD2		V		V	V
BMP8A		V	V	V	V
+ 04392: Hippo signaling pathway - multiple species	0	0	0	0	0
+ 04370: VEGF signaling pathway	0.7	0.1	0.1	0.1	0.1
PIK3CA	V
SH2D2A		V	V	V	V
+ 04371: Apelin signaling pathway	0.3	2	2.3	2.1	2.7
GNB4	V
PRKAA2		V	V	V	V
SERPINE1		V	V	V	V
GNGT1		V
PPARGC1A		V	V	V	V
MYLK3		V	V	V	V
MYL2		V	V	V	V
MYL3		V	V	V	V
ADCY2		V	V	V	V
NOS1		V	V	V	V
SPP1		V	V	V	V
PLIN1		V	V	V	V
APLN		V	V	V	V
CALML6			V	V	V
GNG7					V
PLCB4					V
ADCY5					V
+ 04064: NF-kappa B signaling pathway	0	0	0	0	0
TNFSF11		V
PLAU		V	V	V	V
+ 04668: TNF signaling pathway	0.4	0.4	0.9	0.5	0.2
PIK3CA	V
CXCL5		V	V	V
CXCL10		V	V	V	V
CSF2		V	V	V	V
MMP3		V	V	V	V
MMP9		V	V	V	V
FOS			V
+ 04066: HIF-1 signaling pathway	1	0.5	0.9	0.9	1
PIK3CA	V
TFRC	V
CAMK2B		V	V	V	V
ENO2		V	V	V	V
ENO3		V	V	V	V
TF		V	V	V	V
SERPINE1		V	V	V	V
HKDC1			V	V
EGF					V
IGF1					V
+ 04068: FoxO signaling pathway	1.3	0.1	0.2	0.1	0.2
PIK3CA	V
TNFSF10	V
BCL6	V
PRKAA2		V	V	V	V
PCK1		V	V	V	V
PLK1		V	V	V
SLC2A4		V	V	V	V
EGF					V
IGF1					V
+ 04020: Calcium signaling pathway	0	3.8	3.7	4.3	3.9
NOS1		V	V	V	V
CAMK2B		V	V	V	V
ERBB4		V	V	V	V
GNA14		V	V	V	V
GRIN2D		V	V	V	V
MYLK3		V	V	V	V
PHKG1		V	V	V	V
CACNA1S		V	V	V	V
CACNA1B		V		V
CHRM1		V	V	V	V
HTR2C		V		V
TACR1		V	V	V	V
TNNC2		V	V	V	V
TNNC1		V	V	V	V
ADCY2		V	V	V	V
ATP2A1		V	V	V	V
HTR7		V		V	V
PLN		V	V	V	V
ATP2B2		V	V	V	V
CASQ1		V	V	V	V
CASQ2		V		V
TRDN		V	V	V	V
HRC		V	V	V	V
CALML6			V	V	V
SLC25A4			V		V
PLCB4					V
PTGER3					V
+ 04070: Phosphatidylinositol signaling system	1	0	0	0.1	0.3
PIK3CA	V
DGKG	V
PIK3C2G		V		V	V
IP6K3		V			V
CALML6			V	V	V
PLCB4					V
+ 04072: Phospholipase D signaling pathway	1.2	0	0	0	0.4
PIK3CA	V
PLD1	V
DGKG	V
CXCR2		V	V	V	V
ADCY2		V	V	V	V
FCER1A		V	V	V	V
PLCB4					V
ADCY5					V
EGF					V
AGT					V
+ 04071: Sphingolipid signaling pathway	1.4	0.1	0	0.1	0.1
PIK3CA	V
PLD1	V
KNG1	V
DEGS2		V		V	V
ACER1		V	V	V	V
FCER1A		V	V	V	V
PLCB4					V
+ 04024: cAMP signaling pathway	1.2	2.2	2.8	2.4	3
GHSR	V
PIK3CA	V
PLD1	V
SST	V
CACNA1S		V	V	V	V
ATP2A1		V	V	V	V
ATP1A2		V	V	V	V
CHRM1		V	V	V	V
HTR1D		V	V	V	V
NPY1R		V	V	V	V
ADCY2		V	V	V	V
PLN		V	V	V	V
CFTR		V	V	V	V
ATP2B2		V	V	V	V
CNGB1		V	V	V	V
CNGB3		V
CAMK2B		V	V	V	V
PDE4C		V	V	V	V
GRIN2D		V	V	V	V
FXYD1		V	V	V	V
PPP1R1B		V	V	V	V
EDN3		V	V	V	V
CALML6			V	V	V
FOS			V
PTGER3					V
SSTR1					V
ADCY5					V
VIPR2					V
+ 04022: cGMP-PKG signaling pathway	1	1.2	1.7	1.3	1.9
KCNMB2	V
KCNMB3	V
KNG1	V
CNGB1		V	V	V	V
CACNA1S		V	V	V	V
GATA4		V
ATP2A1		V	V	V	V
PLN		V	V	V	V
ATP1A2		V	V	V	V
ATP2B2		V	V	V	V
MYH6		V	V	V	V
MYH7		V	V	V	V
ADCY2		V	V	V	V
MYLK3		V	V	V	V
SLC25A4			V		V
CALML6			V	V	V
PLCB4					V
ADCY5					V
+ 04151: PI3K-Akt signaling pathway	0.1	3	2.5	2.7	2.3
PIK3CA	V
GNB4	V
ERBB4		V	V	V	V
CHRM1		V	V	V	V
GYS2		V	V	V	V
PCK1		V	V	V	V
NTF3		V		V	V
PGF		V
FGF19		V
PRKAA2		V	V	V	V
GNGT1		V
ITGA11		V	V	V
ITGA5		V	V	V	V
CHAD		V	V	V	V
COL1A1		V	V	V	V
COL1A2		V	V	V	V
COL2A1		V	V	V	V
COL4A1		V	V	V	V
COL4A2		V	V	V	V
COL4A6		V	V	V
COL6A1		V	V	V
COL6A2		V		V
COL6A3		V	V	V	V
LAMB4		V	V	V	V
FN1		V	V	V	V
LAMA1		V	V	V	V
TNC		V
IBSP		V	V	V	V
LAMA3		V	V	V	V
LAMC2		V	V	V	V
RELN		V	V	V
SPP1		V	V	V	V
TNXB		V	V	V	V
COL4A5			V	V	V
EGF					V
FGF7					V
VEGFD					V
IGF1					V
GNG7					V
+ 04152: AMPK signaling pathway	0.8	2	2.3	2.2	2.2
PIK3CA	V
ADIPOQ	V	V	V	V	V
PRKAA2		V	V	V	V
SLC2A4		V	V	V	V
PPARGC1A		V	V	V	V
FBP2		V	V	V	V
GYS2		V	V	V	V
PCK1		V	V	V	V
PPARG		V	V	V	V
CAB39L		V	V	V	V
CCNA1		V		V
CFTR		V	V	V	V
ACACB			V		V
IGF1					V
+ 04150: mTOR signaling pathway	0.6	0.6	0.6	0.7	0.8
PIK3CA	V
DVL3	V
RRAGD		V	V	V	V
RPS6KA6		V	V	V	V
PRKAA2		V	V	V	V
DEPTOR		V	V	V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
FZD2		V		V	V
CAB39L		V	V	V	V
IGF1					V
+ 3.3 Signaling molecules and interaction	1	6	5.8	6.1	4.8
+ 04080: Neuroactive ligand-receptor interaction	0.3	1	0.4	0.9	0.8
GHSR	V
KNG1	V
SST	V
PRSS3		V		V	V
GRIK3		V	V	V	V
GRIN2D		V	V	V	V
GABRA4		V	V	V	V
GABRP		V	V	V	V
NPBWR1		V
GPR50		V		V
F2RL2		V	V	V
TACR1		V	V	V	V
NPY1R		V	V	V	V
HTR1D		V	V	V	V
HTR2C		V		V
HTR7		V		V	V
CHRM1		V	V	V	V
CHRNB4		V		V
APLN		V	V	V	V
GRP		V
EDN3		V	V	V	V
NPW		V	V	V
UCN2		V	V	V	V
GABRB3			V		V
VIPR2					V
PTGER3					V
SSTR1					V
AGT					V
NTS					V
+ 04060: Cytokine-cytokine receptor interaction	0.8	2.6	2.8	2.8	2
IL1RAP	V
THPO	V
IL12A	V
TNFSF10	V
INHBA		V	V	V	V
TNFSF4		V	V	V
CD70		V		V	V
IL22		V		V	V
IL24		V	V	V	V
CSF2		V	V	V	V
CNTFR		V	V	V	V
IL11		V	V	V	V
CX3CR1		V	V	V
CXCR2		V	V	V	V
CXCL13		V	V	V	V
CXCL11		V	V	V	V
CXCL10		V	V	V	V
CXCL9		V			V
CXCL5		V	V	V
TNFSF11		V
CCL11		V	V	V	V
CCL14		V	V	V	V
CXCL17		V	V	V	V
IL36A		V	V	V	V
IL36G		V	V	V	V
IL33		V	V	V	V
BMP3		V	V	V	V
GDF10		V	V	V	V
BMP8A		V	V	V	V
IL1A			V	V
IL17D			V		V
MSTN			V	V
IL34					V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	0.4	2.1	2	1.9	1.7
TNFSF10	V
CCL14		V	V	V	V
CCL11		V	V	V	V
CX3CR1		V	V	V
CXCL5		V	V	V
CXCR2		V	V	V	V
CXCL13		V	V	V	V
CXCL10		V	V	V	V
CXCL9		V			V
CXCL11		V	V	V	V
IL24		V	V	V	V
IL34					V
+ 04512: ECM-receptor interaction	0.5	6.3	6.4	6.5	5
GP5	V
LAMB4		V	V	V	V
LAMA1		V	V	V	V
LAMA3		V	V	V	V
LAMC2		V	V	V	V
COL1A1		V	V	V	V
COL1A2		V	V	V	V
COL2A1		V	V	V	V
COL4A1		V	V	V	V
COL4A2		V	V	V	V
COL4A6		V	V	V
COL6A1		V	V	V
COL6A2		V		V
COL6A3		V	V	V	V
TNC		V
TNXB		V	V	V	V
IBSP		V	V	V	V
SPP1		V	V	V	V
FN1		V	V	V	V
ITGA11		V	V	V
ITGA5		V	V	V	V
CHAD		V	V	V	V
RELN		V	V	V
COL4A5			V	V	V
FREM2					V
+ 4. Cellular Processes	2.8	2.4	2.6	2.3	2.8
+ 4.1 Transport and catabolism	1.9	0.2	0.2	0.1	0.1
+ 04144: Endocytosis	1.9	0	0	0	0
AP2M1	V
PRKCI	V
TFRC	V
PLD1	V
ACAP2	V
WIPF1	V
CXCR2		V	V	V	V
CAV3		V		V
FOLR1		V			V
FOLR3		V	V	V	V
+ 04145: Phagosome	0.2	0.3	0.2	0.1	0
TFRC	V
ITGA5		V	V	V	V
ATP6V0D2		V
ATP6V0A4		V	V	V	V
OLR1		V
NOS1		V	V	V	V
SFTPA2		V	V	V	V
TUBB3			V
+ 04142: Lysosome	0.3	0.1	0	0	0
LAMP3	V
ATP6V0D2		V
ATP6V0A4		V	V	V	V
SLC11A1		V
CTSV			V		V
+ 04146: Peroxisome	1.2	0.1	0.1	0.1	0.2
PEX5L	V
EHHADH	V
ACOX2		V		V	V
EPHX2		V	V	V
MPV17L			V		V
SLC27A2					V
+ 04140: Autophagy - animal	0.8	0	0.1	0.1	0
PIK3CA	V
RUBCN	V
DEPTOR		V	V	V	V
RRAGD		V	V	V	V
PRKAA2		V	V	V	V
+ 04136: Autophagy - other	0	0	0	0	0
+ 04137: Mitophagy - animal	0.6	0	0.1	0	0
MFN1	V
PRKN		V	V	V	V
+ 4.2 Cell growth and death	0.9	0.8	1.4	0.8	1.2
+ 04110: Cell cycle	0	0.5	0.2	0.2	0
ORC6		V
PLK1		V	V	V
PKMYT1		V	V	V	V
SMC1B		V			V
CDC45		V	V	V
CCNA1		V		V
CDC20			V
CDKN2A					V
+ 04114: Oocyte meiosis	0	0.7	1.6	0.9	1.2
PKMYT1		V	V	V	V
RPS6KA6		V	V	V	V
CAMK2B		V	V	V	V
PLK1		V	V	V
ADCY2		V	V	V	V
SMC1B		V			V
AR		V	V	V	V
CDC20			V
CALML6			V	V	V
SPDYC			V
ADCY5					V
IGF1					V
+ 04210: Apoptosis	0.7	0	0.1	0	0
PIK3CA	V
TNFSF10	V
BIRC5		V	V	V	V
FOS			V
CTSV			V		V
+ 04215: Apoptosis - multiple species	0	0.2	0.3	0.3	0.2
BIRC5		V	V	V	V
+ 04216: Ferroptosis	0.9	0.5	1.1	0.5	0.9
TFRC	V
TF		V	V	V	V
CP		V	V	V	V
ALOX15			V		V
+ 04217: Necroptosis	0.2	0	0.3	0.1	0.1
TNFSF10	V
IL33		V	V	V	V
PYGM		V	V	V	V
CAMK2B		V	V	V	V
IL1A			V	V
SLC25A4			V		V
ALOX15			V		V
+ 04115: p53 signaling pathway	0.6	0.1	0	0	0.6
ZMAT3	V
SERPINE1		V	V	V	V
GTSE1		V
RPRM					V
IGF1					V
CDKN2A					V
+ 04218: Cellular senescence	0.2	0.1	0.3	0.3	0.2
PIK3CA	V
CCNA1		V		V
MYBL2		V	V	V	V
FOXM1		V	V	V	V
GATA4		V
SERPINE1		V	V	V	V
IL1A			V	V
CALML6			V	V	V
SLC25A4			V		V
CDKN2A					V
+ 4.3 Cellular community - eukaryotes	1.9	3.4	3.4	3.5	3.7
+ 04510: Focal adhesion	0.4	4.6	4.1	4.6	3.8
PIK3CA	V
PAK2	V
ITGA11		V	V	V
ITGA5		V	V	V	V
MYLK3		V	V	V	V
MYLPF		V		V	V
MYL2		V	V	V	V
CHAD		V	V	V	V
COL1A1		V	V	V	V
COL1A2		V	V	V	V
COL2A1		V	V	V	V
COL4A1		V	V	V	V
COL4A2		V	V	V	V
COL4A6		V	V	V
COL6A1		V	V	V
COL6A2		V		V
COL6A3		V	V	V	V
LAMB4		V	V	V	V
FN1		V	V	V	V
LAMA1		V	V	V	V
TNC		V
IBSP		V	V	V	V
LAMA3		V	V	V	V
LAMC2		V	V	V	V
RELN		V	V	V
SPP1		V	V	V	V
TNXB		V	V	V	V
CAV3		V		V
PGF		V
COL4A5			V	V	V
EGF					V
VEGFD					V
IGF1					V
PAK5					V
+ 04520: Adherens junction	0	0	0	0	0
SORBS1		V	V	V	V
+ 04530: Tight junction	2	2.5	2.8	2.4	3.2
PRKCI	V
CLDN16	V
CLDN11	V		V		V
CLDN1	V
DLG1	V
MYL2		V	V	V	V
CLDN17		V	V	V	V
CLDN10		V	V	V	V
CLDN8		V	V	V	V
PRKAA2		V	V	V	V
AMOT		V	V	V	V
GATA4		V
CFTR		V	V	V	V
TJP3		V	V	V	V
MYH1		V		V
MYH2		V	V	V	V
MYH4		V	V	V	V
MYH11		V	V	V	V
MYH13		V	V	V	V
CGNL1		V	V	V	V
DLG2		V	V	V	V
CLDN23			V
CGN					V
CLDN3					V
MYH7B					V
MYH14					V
+ 04540: Gap junction	0	0.1	0.1	0.1	0.4
HTR2C		V		V
ADCY2		V	V	V	V
TUBB3			V
ADCY5					V
EGF					V
PLCB4					V
+ 04550: Signaling pathways regulating pluripotency of stem cells	1.8	0.6	0.5	0.7	1
DVL3	V
PIK3CA	V
SOX2	V
SKIL	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
FZD2		V		V	V
INHBA		V	V	V	V
ID4		V	V	V	V
LHX5		V	V	V	V
DUSP9		V	V	V	V
IGF1					V
ISL1					V
+ 4.5 Cell motility	0.8	0.3	0.2	0.2	0.5
+ 04810: Regulation of actin cytoskeleton	0.8	0.3	0.2	0.2	0.5
PAK2	V
PIK3CA	V
KNG1	V
SCIN		V	V	V	V
MYLPF		V		V	V
MYL2		V	V	V	V
MYLK3		V	V	V	V
CHRM1		V	V	V	V
ITGA11		V	V	V
ITGA5		V	V	V	V
FN1		V	V	V	V
FGF19		V
PAK5					V
EGF					V
FGF7					V
MYH14					V
+ 5. Organismal Systems	4.7	8.6	9.2	9	11.3
+ 5.1 Immune system	3.5	2	2.1	2	2.1
+ 04640: Hematopoietic cell lineage	1.6	0.2	0.8	0.7	0.1
GP5	V
TFRC	V
THPO	V
ITGA5		V	V	V	V
IL11		V	V	V	V
CSF2		V	V	V	V
CD24			V	V
IL1A			V	V
+ 04610: Complement and coagulation cascades	1.2	2.7	1.8	2.4	2.2
KNG1	V
MASP1	V
SERPINA5		V		V	V
SERPINE1		V	V	V	V
SERPINB2		V
PLAU		V	V	V	V
C6		V	V	V	V
C7		V	V	V	V
PROC		V	V	V	V
CLU		V	V	V	V
F2RL2		V	V	V
CFD		V		V	V
F10					V
+ 04611: Platelet activation	1.4	0.3	0.4	0.4	0.7
GP5	V
PIK3CA	V
PRKCI	V
MYLK3		V	V	V	V
ADCY2		V	V	V	V
COL1A1		V	V	V	V
COL1A2		V	V	V	V
COL3A1		V	V	V	V
PLCB4					V
ADCY5					V
+ 04620: Toll-like receptor signaling pathway	1	0.5	0.4	0.1	0.4
PIK3CA	V
IL12A	V
SPP1		V	V	V	V
CXCL11		V	V	V	V
CXCL10		V	V	V	V
CD80		V			V
CXCL9		V			V
FOS			V
+ 04621: NOD-like receptor signaling pathway	0.5	0	0	0	0
PYDC2	V
MFN1	V
AIM2		V	V	V	V
GBP5		V	V	V	V
PLCB4					V
+ 04622: RIG-I-like receptor signaling pathway	0.6	0.1	0.2	0.2	0.1
IL12A	V
ISG15		V	V	V	V
CXCL10		V	V	V	V
+ 04623: Cytosolic DNA-sensing pathway	0.6	0.5	0.6	0.5	0.4
POLR2H	V
AIM2		V	V	V	V
CXCL10		V	V	V	V
IL33		V	V	V	V
+ 04625: C-type lectin receptor signaling pathway	1	0	0.1	0	0
IL12A	V
PIK3CA	V
IL17D			V		V
CALML6			V	V	V
+ 04650: Natural killer cell mediated cytotoxicity	0.8	0.1	0	0	0
TNFSF10	V
PIK3CA	V
CSF2		V	V	V	V
ULBP2		V		V	V
ULBP1		V
RAET1E		V
+ 04612: Antigen processing and presentation	0	0	0	0	0
+ 04660: T cell receptor signaling pathway	1.6	0	0.1	0	0.1
PIK3CA	V
PAK2	V
DLG1	V
CSF2		V	V	V	V
FOS			V
PAK5					V
CTLA4					V
+ 04658: Th1 and Th2 cell differentiation	0.4	0	0.1	0	0
IL12A	V
DLL3		V		V
FOS			V
MAML3			V
+ 04659: Th17 cell differentiation	0.4	0	0.2	0	0.1
IL1RAP	V
IL22		V		V	V
RORC		V	V	V	V
FOS			V
IL17D			V		V
+ 04657: IL-17 signaling pathway	0	2.3	2.6	2.5	2.2
MMP9		V	V	V	V
MMP13		V	V	V	V
CSF2		V	V	V	V
CCL11		V	V	V	V
MMP1		V	V	V	V
MMP3		V	V	V	V
LCN2		V		V	V
CXCL5		V	V	V
CXCL10		V	V	V	V
MUC5B		V		V	V
FOS			V
IL17D			V		V
+ 04662: B cell receptor signaling pathway	0.5	0	0.1	0	0
PIK3CA	V
FOS			V
LILRA3			V		V
+ 04664: Fc epsilon RI signaling pathway	0.6	0.2	0.2	0.2	0.2
PIK3CA	V
FCER1A		V	V	V	V
CSF2		V	V	V	V
+ 04666: Fc gamma R-mediated phagocytosis	1.1	0	0	0	0
PIK3CA	V
PLD1	V
SCIN		V	V	V	V
+ 04670: Leukocyte transendothelial migration	2	0.9	1.5	1	1.5
CLDN16	V
CLDN11	V		V		V
CLDN1	V
PIK3CA	V
CLDN17		V	V	V	V
CLDN10		V	V	V	V
CLDN8		V	V	V	V
MMP9		V	V	V	V
MYLPF		V		V	V
MYL2		V	V	V	V
THY1		V	V	V	V
CLDN23			V
CLDN3					V
+ 04672: Intestinal immune network for IgA production	0	0.4	0	0.1	0.3
CD80		V			V
PIGR		V		V	V
+ 04062: Chemokine signaling pathway	0.5	0.9	0.7	0.6	0.8
PIK3CA	V
GNB4	V
CX3CR1		V	V	V
CXCR2		V	V	V	V
CXCL13		V	V	V	V
CXCL10		V	V	V	V
CXCL9		V			V
CCL11		V	V	V	V
CCL14		V	V	V	V
CXCL11		V	V	V	V
CXCL5		V	V	V
GNGT1		V
ADCY2		V	V	V	V
PLCB4					V
GNG7					V
ADCY5					V
+ 5.2 Endocrine system	2.3	4.9	6.4	5.6	8
+ 04911: Insulin secretion	1.8	0.7	0.6	0.5	1.4
SLC2A2	V
KCNMB2	V
KCNMB3	V
CACNA1S		V	V	V	V
ADCY2		V	V	V	V
CAMK2B		V	V	V	V
ATP1A2		V	V	V	V
RIMS2		V
KCNJ11					V
PLCB4					V
ADCY5					V
+ 04910: Insulin signaling pathway	0.7	1.7	3.2	2.4	2.2
PIK3CA	V
PRKCI	V
PRKAA2		V	V	V	V
PPP1R3A		V	V	V	V
PPP1R3C		V	V	V	V
GYS2		V	V	V	V
PHKG1		V	V	V	V
PYGM		V	V	V	V
PCK1		V	V	V	V
FBP2		V	V	V	V
PPARGC1A		V	V	V	V
SORBS1		V	V	V	V
SLC2A4		V	V	V	V
SOCS1			V
CALML6			V	V	V
ACACB			V		V
HKDC1			V	V
+ 04922: Glucagon signaling pathway	0.4	1.7	2.7	2.2	2.6
SLC2A2	V
PGAM2		V	V	V	V
ADCY2		V	V	V	V
GYS2		V	V	V	V
PYGM		V	V	V	V
PPARGC1A		V	V	V	V
PCK1		V	V	V	V
PHKG1		V	V	V	V
PRKAA2		V	V	V	V
CAMK2B		V	V	V	V
CALML6			V	V	V
ACACB			V		V
PLCB4					V
+ 04923: Regulation of lipolysis in adipocytes	0.7	1	1.6	1.5	2.2
PIK3CA	V
ADCY2		V	V	V	V
PLIN1		V	V	V	V
AQP7		V	V	V	V
NPY1R		V	V	V	V
MGLL			V	V	V
ADCY5					V
PTGER3					V
+ 04920: Adipocytokine signaling pathway	0.6	1.1	1.7	1.2	1.4
ADIPOQ	V	V	V	V	V
PCK1		V	V	V	V
PRKAA2		V	V	V	V
SLC2A4		V	V	V	V
PPARGC1A		V	V	V	V
ACACB			V		V
+ 03320: PPAR signaling pathway	1.2	4.5	3.8	4	4.1
EHHADH	V
ADIPOQ	V	V	V	V	V
AQP7		V	V	V	V
PCK1		V	V	V	V
PLIN5		V	V	V	V
PLIN1		V	V	V	V
SLC27A6		V	V	V	V
FABP7		V	V	V	V
PPARG		V	V	V	V
ACADL		V	V	V	V
OLR1		V
HMGCS2		V	V	V	V
SORBS1		V	V	V	V
MMP1		V	V	V	V
ACOX2		V		V	V
FADS2		V
SLC27A2					V
+ 04912: GnRH signaling pathway	0.4	0.2	0.5	0.4	0.9
PLD1	V
ADCY2		V	V	V	V
CAMK2B		V	V	V	V
CACNA1S		V	V	V	V
CALML6			V	V	V
ADCY5					V
PLCB4					V
+ 04913: Ovarian steroidogenesis	0	0.7	0.4	0.8	2
CYP11A1		V	V	V	V
ADCY2		V	V	V	V
CYP2J2		V		V	V
ADCY5					V
CYP1A1					V
IGF1					V
+ 04915: Estrogen signaling pathway	0.3	1.1	2.2	1.5	2.7
PIK3CA	V
MMP9		V	V	V	V
ADCY2		V	V	V	V
KRT40		V	V	V	V
KRT23		V	V	V	V
KRT13		V	V	V	V
KRT17		V	V	V	V
KRT32		V	V	V	V
KRT33A		V	V	V	V
KRT36		V	V	V	V
FOS			V
CALML6			V	V	V
KRT9			V
PLCB4					V
ADCY5					V
KRT16					V
KRT19					V
TFF1					V
+ 04914: Progesterone-mediated oocyte maturation	0.4	0.6	0.8	0.7	0.6
PIK3CA	V
ADCY2		V	V	V	V
PLK1		V	V	V
PKMYT1		V	V	V	V
RPS6KA6		V	V	V	V
CCNA1		V		V
SPDYC			V
IGF1					V
ADCY5					V
+ 04917: Prolactin signaling pathway	1.3	0.1	0.2	0	0
PIK3CA	V
SLC2A2	V
ELF5		V		V	V
TNFSF11		V
SOCS1			V
FOS			V
+ 04921: Oxytocin signaling pathway	0	0.6	1.1	0.7	1.1
MYLK3		V	V	V	V
ADCY2		V	V	V	V
CAMK2B		V	V	V	V
CACNG6		V	V	V	V
CACNA1S		V	V	V	V
CACNB4		V	V	V	V
CACNG1		V
PRKAA2		V	V	V	V
CALML6			V	V	V
FOS			V
ADCY5					V
PLCB4					V
+ 04926: Relaxin signaling pathway	0.8	2.1	2.7	2.3	2.9
PIK3CA	V
GNB4	V
GNGT1		V
MMP9		V	V	V	V
NOS1		V	V	V	V
COL1A1		V	V	V	V
COL1A2		V	V	V	V
COL3A1		V	V	V	V
COL4A1		V	V	V	V
COL4A2		V	V	V	V
COL4A6		V	V	V
MMP1		V	V	V	V
MMP13		V	V	V	V
ADCY2		V	V	V	V
COL4A5			V	V	V
FOS			V
GNG7					V
ADCY5					V
VEGFD					V
PLCB4					V
+ 04918: Thyroid hormone synthesis	0	0.6	0.8	0.7	1.3
ADCY2		V	V	V	V
ATP1A2		V	V	V	V
IYD		V	V	V	V
GPX3		V	V	V	V
PLCB4					V
ADCY5					V
+ 04919: Thyroid hormone signaling pathway	0.3	0.8	0.7	0.6	0.5
PIK3CA	V
GATA4		V
MYH6		V	V	V	V
MYH7		V	V	V	V
ATP2A1		V	V	V	V
PLN		V	V	V	V
ATP1A2		V	V	V	V
KAT2B		V	V	V
PLCB4					V
+ 04928: Parathyroid hormone synthesis, secretion and action	0.4	1.3	1.2	1.1	1.6
PLD1	V
ADCY2		V	V	V	V
PTHLH		V	V	V	V
PDE4C		V	V	V	V
CYP27B1		V	V	V	V
TNFSF11		V
SOST		V	V	V	V
MMP13		V	V	V	V
SLC34A3		V
FOS			V
SLC34A2				V	V
PLCB4					V
ADCY5					V
+ 04916: Melanogenesis	0.4	0.8	1	1.2	2
DVL3	V
DCT		V	V	V	V
CAMK2B		V	V	V	V
FZD2		V		V	V
ADCY2		V	V	V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
CALML6			V	V	V
TYRP1					V
PLCB4					V
ADCY5					V
+ 04924: Renin secretion	0	0.4	0.9	0.8	1.8
CLCA4		V	V	V	V
CACNA1S		V	V	V	V
EDN3		V	V	V	V
CALML6			V	V	V
ADCY5					V
PLCB4					V
AGT					V
+ 04614: Renin-angiotensin system	0	0.4	0	0	0.4
CMA1		V
AGT					V
+ 04925: Aldosterone synthesis and secretion	0	1.2	1.7	1.6	2.4
CACNA1S		V	V	V	V
ADCY2		V	V	V	V
CAMK2B		V	V	V	V
CYP11A1		V	V	V	V
CYP21A2		V	V	V	V
ATP1A2		V	V	V	V
ATP2B2		V	V	V	V
CALML6			V	V	V
PLCB4					V
ADCY5					V
AGT					V
+ 04927: Cortisol synthesis and secretion	0.6	0.8	1.8	1.3	2.3
NCEH1	V
CACNA1S		V	V	V	V
ADCY2		V	V	V	V
CYP11A1		V	V	V	V
CYP21A2		V	V	V	V
NR5A1			V	V
PBX1			V		V
PLCB4					V
ADCY5					V
AGT					V
+ 5.3 Circulatory system	0.4	4.6	4.9	4.9	5.4
+ 04260: Cardiac muscle contraction	0	4.5	4.1	4.3	3.8
CACNG6		V	V	V	V
CACNA1S		V	V	V	V
CACNB4		V	V	V	V
CACNG1		V
ATP2A1		V	V	V	V
TNNC1		V	V	V	V
MYH6		V	V	V	V
MYH7		V	V	V	V
MYL2		V	V	V	V
MYL3		V	V	V	V
COX6A2		V	V	V	V
COX7A1		V	V	V	V
ATP1A2		V	V	V	V
TRDN		V	V	V	V
CASQ2		V		V
HRC		V	V	V	V
+ 04261: Adrenergic signaling in cardiomyocytes	0	3.1	3.5	3.3	3.8
CACNG6		V	V	V	V
CACNA1S		V	V	V	V
CACNB4		V	V	V	V
CACNG1		V
ATP2A1		V	V	V	V
TNNC1		V	V	V	V
MYH6		V	V	V	V
MYH7		V	V	V	V
MYL2		V	V	V	V
MYL3		V	V	V	V
ATP1A2		V	V	V	V
ADCY2		V	V	V	V
PLN		V	V	V	V
SCN7A		V	V	V	V
PPP1R1A		V	V	V	V
CAMK2B		V	V	V	V
ATP2B2		V	V	V	V
CALML6			V	V	V
ADCY5					V
PLCB4					V
AGT					V
+ 04270: Vascular smooth muscle contraction	0.8	0.4	0.8	0.8	1.7
KCNMB2	V
KCNMB3	V
MYLK3		V	V	V	V
CACNA1S		V	V	V	V
PLA2G2A		V	V	V	V
ADCY2		V	V	V	V
MYH11		V	V	V	V
EDN3		V	V	V	V
CALML6			V	V	V
PLCB4					V
PLA2G2F					V
ADCY5					V
AGT					V
+ 5.4 Digestive system	1.8	6.6	6.5	7.2	7.8
+ 04970: Salivary secretion	0	4.1	4.4	5.2	6.1
ADCY2		V	V	V	V
ATP2B2		V	V	V	V
AQP5		V	V	V	V
NOS1		V	V	V	V
TRPV6		V	V	V	V
MUC5B		V		V	V
MUC7		V	V	V	V
PRH1		V	V	V	V
PRH2		V	V	V	V
AMY1A		V	V	V	V
HTN1		V	V	V	V
HTN3		V	V	V	V
STATH		V	V	V	V
ATP1A2		V	V	V	V
LPO		V	V	V	V
CALML6			V	V	V
CST1				V
DMBT1				V	V
ADCY5					V
PLCB4					V
PRB1					V
CST5					V
LYZ					V
+ 04971: Gastric acid secretion	0.6	2.1	2.7	2.6	3.1
SST	V
ADCY2		V	V	V	V
GAST		V	V	V	V
CFTR		V	V	V	V
ATP1A2		V	V	V	V
SLC9A4		V	V	V	V
KCNJ16		V	V	V	V
MYLK3		V	V	V	V
CAMK2B		V	V	V	V
CALML6			V	V	V
ADCY5					V
PLCB4					V
+ 04972: Pancreatic secretion	0	1.9	1.8	2	2.8
ATP2B2		V	V	V	V
ATP1A2		V	V	V	V
CFTR		V	V	V	V
CLCA4		V	V	V	V
SLC4A4		V	V	V	V
PRSS3		V		V	V
PLA2G2A		V	V	V	V
ATP2A1		V	V	V	V
ADCY2		V	V	V	V
PLCB4					V
PLA2G2F					V
ADCY5					V
+ 04976: Bile secretion	1.3	2.5	2.4	2.7	2.8
SLC51A	V
NCEH1	V
AQP9		V		V
ATP1A2		V	V	V	V
CFTR		V	V	V	V
SLC4A4		V	V	V	V
ADCY2		V	V	V	V
SLCO1B3		V	V	V	V
SLC5A1		V	V	V	V
CYP3A4		V	V	V	V
AQP4		V	V	V	V
ADCY5					V
SLC9A3					V
+ 04973: Carbohydrate digestion and absorption	2.5	0.8	1.5	1.4	0.8
SLC2A2	V
SI	V
PIK3CA	V
SLC5A1		V	V	V	V
ATP1A2		V	V	V	V
AMY1A		V	V	V	V
HKDC1			V	V
+ 04974: Protein digestion and absorption	0	6.7	5.9	6.6	5.8
PRSS3		V		V	V
ATP1A2		V	V	V	V
XPNPEP2		V		V	V
COL1A1		V	V	V	V
COL1A2		V	V	V	V
COL2A1		V	V	V	V
COL3A1		V	V	V	V
COL4A1		V	V	V	V
COL4A2		V	V	V	V
COL4A6		V	V	V
COL5A1		V	V	V	V
COL5A2		V	V	V	V
COL6A1		V	V	V
COL6A2		V		V
COL6A3		V	V	V	V
COL7A1		V	V	V	V
COL10A1		V	V	V	V
COL11A1		V	V	V	V
COL12A1		V	V	V	V
COL13A1		V	V	V	V
COL22A1		V	V	V	V
COL24A1		V
COL5A3		V		V
COL27A1		V
SLC1A1			V		V
COL4A5			V	V	V
SLC9A3					V
+ 04975: Fat digestion and absorption	0	0.2	0.2	0.2	0.5
PLA2G2A		V	V	V	V
PLA2G2F					V
+ 04979: Cholesterol metabolism	0.8	0.4	0.1	0.1	0.3
NCEH1	V
APOC1		V			V
PCSK9		V	V	V	V
+ 04977: Vitamin digestion and absorption	0	0.4	0	0	0
LRAT		V
+ 04978: Mineral absorption	0.7	1.9	1.7	2	2.3
CLCN2	V
TRPV6		V	V	V	V
TF		V	V	V	V
MT1A		V	V	V	V
ATP1A2		V	V	V	V
SLC5A1		V	V	V	V
SLC26A9		V
SLC34A2				V	V
SLC9A3					V
+ 5.5 Excretory system	0.8	2.6	2.1	2.3	3.1
+ 04962: Vasopressin-regulated water reabsorption	0	0.4	0.5	0.5	0.1
AQP4		V	V	V	V
AQP3		V	V	V
+ 04960: Aldosterone-regulated sodium reabsorption	0.9	2.1	1.2	1.6	2
PIK3CA	V
SCNN1A		V		V	V
SCNN1B		V	V	V	V
SCNN1G		V
ATP1A2		V	V	V	V
NR3C2		V	V	V	V
IGF1					V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	0.8	0.3	0.4	0.4	0.7
AP2M1	V
CALB1		V	V	V	V
ATP1A2		V	V	V	V
PLCB4					V
+ 04964: Proximal tubule bicarbonate reclamation	0	2.2	2.3	2.3	3.3
SLC4A4		V	V	V	V
ATP1A2		V	V	V	V
SLC38A3		V	V	V	V
PCK1		V	V	V	V
SLC9A3					V
CA4					V
+ 04966: Collecting duct acid secretion	0	0.8	0.4	0.3	0.8
ATP6V0D2		V
ATP6V0A4		V	V	V	V
CLCNKB					V
+ 5.6 Nervous system	1.9	2.7	2.6	2.5	3.8
+ 04724: Glutamatergic synapse	0.9	0.4	0.5	0.3	1.1
GNB4	V
PLD1	V
GRIK3		V	V	V	V
GRIN2D		V	V	V	V
ADCY2		V	V	V	V
SLC38A3		V	V	V	V
GNGT1		V
SLC1A1			V		V
ADCY5					V
PLCB4					V
GNG7					V
+ 04727: GABAergic synapse	0.5	2.1	2.3	1.8	2.3
GNB4	V
ADCY2		V	V	V	V
SLC6A1		V	V	V	V
CACNA1B		V		V
GNGT1		V
GABRA4		V	V	V	V
GABRP		V	V	V	V
HAP1		V	V	V	V
CACNA1S		V	V	V	V
SLC38A3		V	V	V	V
GAD1			V
GABRB3			V		V
ADCY5					V
GNG7					V
+ 04725: Cholinergic synapse	0.9	0.9	0.5	0.7	1.1
GNB4	V
PIK3CA	V
CHRNB4		V		V
CHRM1		V	V	V	V
ADCY2		V	V	V	V
CACNA1B		V		V
GNGT1		V
CAMK2B		V	V	V	V
CACNA1S		V	V	V	V
FOS			V
ADCY5					V
PLCB4					V
GNG7					V
KCNQ4					V
+ 04728: Dopaminergic synapse	0.3	0.2	0.4	0.3	0.6
GNB4	V
MAOB		V	V	V	V
CACNA1B		V		V
GNGT1		V
PPP1R1B		V	V	V	V
CAMK2B		V	V	V	V
FOS			V
CALML6			V	V	V
ADCY5					V
PLCB4					V
GNG7					V
+ 04726: Serotonergic synapse	2	2.7	1.7	2.3	3.3
GNB4	V
HTR3C	V
HTR3D	V
HTR3E	V
HTR7		V		V	V
HTR2C		V		V
SLC6A4		V	V	V	V
CACNA1B		V		V
HTR1D		V	V	V	V
GNGT1		V
MAOB		V	V	V	V
CACNA1S		V	V	V	V
HTR3A		V			V
HTR3B		V	V	V	V
CYP2C18		V
CYP2J2		V		V	V
CYP4X1		V	V	V	V
ALOX12			V	V	V
ALOX15			V		V
GABRB3			V		V
ADCY5					V
PLCB4					V
GNG7					V
+ 04720: Long-term potentiation	0	0.7	1.3	1.2	1.5
CAMK2B		V	V	V	V
RPS6KA6		V	V	V	V
GRIN2D		V	V	V	V
PPP1R1A		V	V	V	V
CALML6			V	V	V
PLCB4					V
+ 04730: Long-term depression	0	0	0.1	0.1	0.5
NOS1		V	V	V	V
PLCB4					V
IGF1					V
+ 04723: Retrograde endocannabinoid signaling	0.7	0.3	0.4	0.4	0.9
GNB4	V
NDUFB5	V
CACNA1B		V		V
CACNA1S		V	V	V	V
GABRA4		V	V	V	V
GABRP		V	V	V	V
GNGT1		V
ADCY2		V	V	V	V
GABRB3			V		V
MGLL			V	V	V
PLCB4					V
GNG7					V
ADCY5					V
+ 04721: Synaptic vesicle cycle	0.5	0.9	0.7	0.6	0.5
AP2M1	V
CACNA1B		V		V
ATP6V0D2		V
ATP6V0A4		V	V	V	V
SLC6A1		V	V	V	V
SLC6A4		V	V	V	V
SLC1A1			V		V
+ 04722: Neurotrophin signaling pathway	0.3	0.2	0.3	0.4	0.3
PIK3CA	V
NTRK3		V	V	V	V
NTF3		V		V	V
RPS6KA6		V	V	V	V
CAMK2B		V	V	V	V
CALML6			V	V	V
+ 5.7 Sensory system	1.7	1.9	1.3	1.8	1.9
+ 04744: Phototransduction	0	1.4	1.5	1.5	1.4
CNGB1		V	V	V	V
PDE6A		V	V	V	V
GNGT1		V
CALML6			V	V	V
+ 04740: Olfactory transduction	0	0	0	0	0
CNGB1		V	V	V	V
CAMK2B		V	V	V	V
CALML6			V	V	V
GNG7					V
+ 04742: Taste transduction	1.8	1.5	0.6	0.9	1.1
HTR3C	V
HTR3D	V
HTR3E	V
SCNN1A		V		V	V
SCNN1B		V	V	V	V
SCNN1G		V
GABRA4		V	V	V	V
HTR1D		V	V	V	V
HTR3A		V			V
HTR3B		V	V	V	V
+ 04750: Inflammatory mediator regulation of TRP channels	1.6	0.8	0.4	1.3	1.4
IL1RAP	V
PIK3CA	V
KNG1	V
HTR2C		V		V
ADCY2		V	V	V	V
CAMK2B		V	V	V	V
TRPA1		V
CYP2J2		V		V	V
TRPV3		V		V
ALOX12			V	V	V
CALML6			V	V	V
PLCB4					V
ADCY5					V
IGF1					V
+ 5.8 Development and regeneration	0.9	0.1	0.6	0.1	0.1
+ 04360: Axon guidance	0.9	0.1	0.2	0.1	0.1
PAK2	V
EPHB3	V
PIK3CA	V
ROBO2		V	V	V	V
EPHB2		V	V	V	V
SEMA3E		V	V	V	V
SEMA5B		V
CAMK2B		V	V	V	V
BOC		V	V	V
EPHA6			V
PAK5					V
EPHA7					V
+ 04380: Osteoclast differentiation	0.3	0	0.6	0.1	0
PIK3CA	V
TNFSF11		V
PPARG		V	V	V	V
TREM2		V	V	V	V
IL1A			V	V
FOS			V
SOCS1			V
LILRA3			V		V
+ 5.9 Aging	1.2	0.8	1	0.9	1.8
+ 04211: Longevity regulating pathway	1.1	0.7	0.9	0.8	1.3
PIK3CA	V
ADIPOQ	V	V	V	V	V
ADCY2		V	V	V	V
PRKAA2		V	V	V	V
PPARGC1A		V	V	V	V
PPARG		V	V	V	V
IGF1					V
ADCY5					V
+ 04213: Longevity regulating pathway - multiple species	0.7	0.5	0.6	0.6	1.2
PIK3CA	V
ADCY2		V	V	V	V
PRKAA2		V	V	V	V
CRYAB		V	V	V	V
IGF1					V
ADCY5					V
+ 5.10 Environmental adaptation	0.4	1	1.6	1.3	1.7
+ 04710: Circadian rhythm	0	0.7	0.8	0.8	0.7
RORC		V	V	V	V
PRKAA2		V	V	V	V
+ 04713: Circadian entrainment	0.4	0.6	1.1	0.7	1.5
GNB4	V
GRIN2D		V	V	V	V
CAMK2B		V	V	V	V
NOS1		V	V	V	V
GNGT1		V
ADCY2		V	V	V	V
CALML6			V	V	V
FOS			V
PLCB4					V
GNG7					V
ADCY5					V
+ 04714: Thermogenesis	0.3	0.5	0.9	0.8	0.8
ACTL6A	V
NDUFB5	V
PPARGC1A		V	V	V	V
ADCY2		V	V	V	V
PPARG		V	V	V	V
DPF1		V	V	V	V
PLIN1		V	V	V	V
RPS6KA6		V	V	V	V
KLB		V	V	V	V
PRKAA2		V	V	V	V
BMP8A		V	V	V	V
COX6A2		V	V	V	V
COX7A1		V	V	V	V
MGLL			V	V	V
ADCY5					V
+ 6. Human Diseases	4.2	2.5	2.7	2.9	4.3
+ 6.1 Cancer: overview	2.8	2.7	2.7	3.1	3.8
+ 05200: Pathways in cancer	1.4	0.5	0.4	0.6	1.6
DVL3	V
PIK3CA	V
PLD1	V
MECOM	V
GNB4	V
HES1	V
NFE2L2	V
IL12A	V
KNG1	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
COL4A1		V	V	V	V
COL4A2		V	V	V	V
COL4A6		V	V	V
LAMB4		V	V	V	V
FN1		V	V	V	V
LAMA1		V	V	V	V
LAMA3		V	V	V	V
LAMC2		V	V	V	V
FZD2		V		V	V
AR		V	V	V	V
PPARG		V	V	V	V
ZBTB16		V	V	V	V
CCNA1		V		V
BIRC5		V	V	V	V
PGF		V
MMP1		V	V	V	V
MMP9		V	V	V	V
FGF19		V
ADCY2		V	V	V	V
GNGT1		V
DLL3		V		V
GSTA1		V		V	V
MGST1		V	V	V	V
CAMK2B		V	V	V	V
COL4A5			V	V	V
FOS			V
CALML6			V	V	V
EGF					V
IGF1					V
CDKN2A					V
VEGFD					V
FGF7					V
PTGER3					V
ADCY5					V
GNG7					V
PLCB4					V
GSTA2					V
GSTM5					V
TERT					V
AGT					V
+ 05202: Transcriptional misregulation in cancer	0.9	2.2	2.3	2.1	2.1
MLF1	V
ETV5	V
BCL6	V
PPARG		V	V	V	V
TMPRSS2		V	V	V	V
PLAU		V	V	V	V
MMP3		V	V	V	V
MMP9		V	V	V	V
ZBTB16		V	V	V	V
CCNA1		V		V
HOXA9		V		V
HOXA10		V	V	V	V
HMGA2		V	V	V	V
PROM1		V		V	V
CSF2		V	V	V	V
HOXA11		V	V	V	V
HPGD		V	V	V	V
TLX3		V
HIST1H3G		V	V	V
CEBPE			V
PBX1			V		V
EYA1			V		V
IGF1					V
TLX1					V
+ 05206: MicroRNAs in cancer	1.2	1.2	1.4	1	1.1
TP63	V
HOXD10	V	V	V	V	V
PIK3CA	V
DNMT3B		V	V	V	V
HMGA2		V	V	V	V
MMP9		V	V	V	V
CDCA5		V	V	V	V
TNC		V
TNXB		V	V	V	V
ITGA5		V	V	V	V
PLAU		V	V	V	V
IGF2BP1		V	V	V	V
SOCS1			V
CDKN2A					V
+ 05205: Proteoglycans in cancer	0.4	1	1	1.4	0.9
PIK3CA	V
HOXD10	V	V	V	V	V
CAMK2B		V	V	V	V
MMP9		V	V	V	V
PLAU		V	V	V	V
ERBB4		V	V	V	V
LUM		V	V	V
FZD2		V		V	V
ITGA5		V	V	V	V
FN1		V	V	V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
CAV3		V		V
ANK2			V	V	V
IGF1					V
+ 05204: Chemical carcinogenesis	0	3.3	2.5	3.8	5.5
CYP2E1		V	V	V	V
UGT1A8		V	V	V	V
ALDH3A1		V		V	V
ADH1A		V		V	V
ADH1B		V	V	V	V
ADH1C		V	V	V	V
ADH4		V	V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
CYP3A4		V	V	V	V
CYP2C18		V
CYP3A5		V	V	V	V
UGT1A7			V	V	V
UGT1A10				V	V
CYP1A1					V
UGT1A6					V
UGT1A9					V
ADH7					V
GSTA2					V
GSTM5					V
+ 05203: Viral carcinogenesis	0.4	0	0	0	0
DLG1	V
PIK3CA	V
KAT2B		V	V	V
CCNA1		V		V
ATP6V0D2		V
SCIN		V	V	V	V
CDC20			V
CDKN2A					V
+ 05230: Central carbon metabolism in cancer	1.3	0.2	0.5	0.4	0.1
SLC2A2	V
PIK3CA	V
NTRK3		V	V	V	V
PGAM2		V	V	V	V
HKDC1			V	V
+ 05231: Choline metabolism in cancer	2.2	0	0	0	0
PIK3CA	V
PCYT1A	V
PLD1	V
DGKG	V
FOS			V
EGF					V
SLC44A4					V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	0.5	0	0	0	0
PIK3CA	V
FOS			V
EGF					V
+ 6.2 Cancer: specific types	3.1	1.1	1.2	1.2	2
+ 05210: Colorectal cancer	0.5	0	0.1	0	0.1
PIK3CA	V
BIRC5		V	V	V	V
FOS			V
EGF					V
+ 05212: Pancreatic cancer	1.2	0	0	0	0.1
PIK3CA	V
PLD1	V
EGF					V
CDKN2A					V
+ 05225: Hepatocellular carcinoma	1.5	0.2	0.1	0.2	0.9
PIK3CA	V
DVL3	V
NFE2L2	V
ACTL6A	V
FZD2		V		V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
DPF1		V	V	V	V
TERT					V
GSTA2					V
GSTM5					V
CDKN2A					V
+ 05226: Gastric cancer	0.7	0.1	0	0	0.3
PIK3CA	V
DVL3	V
FZD2		V		V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
FGF19		V
TERT					V
FGF7					V
EGF					V
+ 05214: Glioma	0.6	0	0.2	0.1	0.9
PIK3CA	V
CAMK2B		V	V	V	V
CALML6			V	V	V
EGF					V
IGF1					V
CDKN2A					V
+ 05216: Thyroid cancer	0	0.2	0.2	0.2	0.2
PPARG		V	V	V	V
+ 05221: Acute myeloid leukemia	0.6	0.4	0.5	0.5	0.2
PIK3CA	V
ZBTB16		V	V	V	V
CCNA1		V		V
CSF2		V	V	V	V
CEBPE			V
+ 05220: Chronic myeloid leukemia	1.2	0	0	0	0
MECOM	V
PIK3CA	V
CDKN2A					V
+ 05217: Basal cell carcinoma	0.6	0.5	0.3	0.5	0.4
DVL3	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
FZD2		V		V	V
+ 05218: Melanoma	0.6	0	0	0	0.6
PIK3CA	V
FGF19		V
EGF					V
FGF7					V
IGF1					V
CDKN2A					V
+ 05211: Renal cell carcinoma	1.3	0	0	0	0
PAK2	V
PIK3CA	V
PAK5					V
+ 05219: Bladder cancer	0	0.5	0.6	0.5	1.4
MMP1		V	V	V	V
MMP9		V	V	V	V
CDKN2A					V
EGF					V
+ 05215: Prostate cancer	1	0.6	0.7	0.7	1.1
PIK3CA	V
ETV5	V
AR		V	V	V	V
TMPRSS2		V	V	V	V
PLAU		V	V	V	V
MMP3		V	V	V	V
MMP9		V	V	V	V
EGF					V
IGF1					V
+ 05213: Endometrial cancer	0.7	0	0	0	0.1
PIK3CA	V
EGF					V
+ 05224: Breast cancer	1.2	0.3	0	0.1	0.3
PIK3CA	V
DVL3	V
HES1	V
DLL3		V		V
FZD2		V		V	V
WNT2		V	V	V	V
WNT7A		V	V	V	V
TNFSF11		V
FGF19		V
FOS			V
IGF1					V
EGF					V
FGF7					V
+ 05222: Small cell lung cancer	0.4	1.6	2.2	2.1	1.6
PIK3CA	V
COL4A1		V	V	V	V
COL4A2		V	V	V	V
COL4A6		V	V	V
LAMB4		V	V	V	V
FN1		V	V	V	V
LAMA1		V	V	V	V
LAMA3		V	V	V	V
LAMC2		V	V	V	V
COL4A5			V	V	V
+ 05223: Non-small cell lung cancer	0.6	0	0	0	0.2
PIK3CA	V
EGF					V
CDKN2A					V
+ 6.12 Drug resistance: antineoplastic	1.3	0.6	0.7	0.7	1.7
+ 01521: EGFR tyrosine kinase inhibitor resistance	0.5	0	0.1	0	0.3
PIK3CA	V
NRG2		V	V	V	V
NRG1			V
EGF					V
IGF1					V
+ 01524: Platinum drug resistance	0.6	0.3	0.2	0.4	1.3
PIK3CA	V
BIRC5		V	V	V	V
GSTA1		V		V	V
MGST1		V	V	V	V
GSTA2					V
GSTM5					V
CDKN2A					V
+ 01523: Antifolate resistance	1	0.7	0.8	0.8	1.3
ABCC5	V
FOLR1		V			V
FOLR3		V	V	V	V
ALOX12			V	V	V
+ 01522: Endocrine resistance	0.4	0.1	0.2	0.2	0.5
PIK3CA	V
MMP9		V	V	V	V
ADCY2		V	V	V	V
DLL3		V		V
FOS			V
ADCY5					V
CDKN2A					V
IGF1					V

**Save / Export**
META-Z-score:	download
Z-score:	download
Genes in pathway/subsystem/system:	download