• Score Type:
• Meta Z-score
• Z-score
• No. of Genes

HisBIM: A Hierarchical System Biology Model

System/Subsystem/Pathway	Z-score
	LH-LN up	LH-LN down	LJ'-LH up	LJ'-LH down	AH-AN up	AH-AN down	AJ'-AH up	AJ'-AH down	LN-AN up	LN-AN down
	340/652	302/553	142/306	197/355	991/2080	652/1363	255/548	298/615	1164/2353	2831/6542
+ 1. Metabolism	20	10.2	5.3	12	9	20.1	9.5	5.5	30.1	11.2
+ 1.0 Global and overview maps	10.7	2.9	2.5	6.4	3.5	11.8	6	1.6	16.7	6.3
+ 01100: Metabolic pathways	12.4	4.1	3.3	6.9	3.3	12.9	5.8	2.3	17.5	5.1
Hexb	V									V
Chkb	V							V		V
Etnk2	V								V
Fasn	V			V		V				V
Acsf3	V					V				V
Kyat3	V					V			V	V
Kyat1	V							V	V
Hadh	V
Pomt1	V					V				V
Pts	V					V				V
Bckdhb	V								V	V
Gal3st1	V
Fads2	V								V
Elovl5	V			V					V
Fads1	V							V	V
Acaa1a	V								V	V
Acox1	V							V	V	V
Scp2	V	V		V		V			V
Acaa1b	V			V					V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Gstk1	V					V
Dglucy	V
Glul	V					V				V
Gls2	V			V					V
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Pgm1	V					V				V
Pik3cb	V					V				V
Ipmk	V								V
Maob	V					V
Hnmt	V					V				V
Acadm	V									V
Aldh4a1	V			V						V
Alas1	V		V	V		V			V	V
Sds	V								V
Enpp3	V								V
Upp2	V		V			V			V	V
Tk1	V				V				V
Tk2	V			V	V	V		V
Adcy6	V					V				V
Nme2	V									V
Uox	V								V
Pklr	V								V
Gda	V
Selenbp1	V			V		V			V
Esd	V								V
Acss2	V			V		V				V
Hagh	V					V	V		V	V
Acaca	V					V
Dhdh	V					V
Chac1	V									V
Gaa	V			V						V
Pcyt1a	V								V
Chpt1	V					V				V
Nagk	V									V
Cyp2c50	V			V					V
Cyp2a4	V								V
Cyp2c39	V								V
Prdx6	V					V			V	V
Tpk1	V					V			V
Hykk	V								V
Lpin2	V								V
Papss2	V				V					V
Hsd11b1	V					V			V
Hsd3b2	V		V						V
Ugp2	V					V			V
Ido2	V								V
Gamt	V								V
Pgls	V					V				V
Dcxr	V								V
Gne	V								V
Gcdh	V								V
Dhtkd1	V		V			V	V			V
Asl	V								V
Haao	V								V	V
Aox3	V					V			V
Bhmt	V								V
Ivd	V					V				V
Mccc1	V								V
Acat1	V
Dhcr7	V	V		V	V				V
Akr1d1	V								V
Cyp17a1	V								V
Fbp1	V								V
Cmpk1	V				V
Uck1	V					V				V
Pla2g6	V			V	V	V	V			V
Agpat2	V					V				V
Gpam	V			V
Gpat3	V									V
Smpd2	V									V
Sgms2	V
Asah2	V
Cers2	V								V	V
Nmnat1	V	V
Nudt12	V								V
Nmnat3	V
Nadsyn1	V								V
Sirt2	V				V					V
Sirt5	V					V				V
Sirt1	V		V	V
Nadk2	V		V		V	V			V
Nnmt	V									V
Dgat1	V					V	V			V
Lipg	V			V					V
Cmbl	V				V		V
Pank1	V								V
Coasy	V					V			V	V
Cpox	V								V	V
Oat	V			V					V
Hao2	V
Acsm3	V					V			V	V
Gk	V				V				V
Hsd17b10	V		V			V				V
Gck	V			V					V
Alg3	V	V							V	V
Extl2	V						V			V
Extl1	V								V
Idh1	V								V
Acot2	V					V				V
Acot3	V		V
Acot4	V		V			V			V
Aldh1a1	V					V			V	V
Rdh16	V								V
Dhrs4	V						V		V
Treh	V
Ahcyl2	V	V		V		V				V
Acss3	V						V			V
Gys2	V								V
Csgalnact2	V									V
Nqo1	V
Dhfr	V								V
Qdpr	V			V					V
Suox	V					V			V
Prodh2	V		V						V
Prodh	V					V	V			V
Inmt	V					V			V
Cox4i1	V					V				V
Ndufs8	V						V			V
Ndufa11	V			V						V
Suv39h1	V									V
Kmt2e	V									V
Etnk1		V							V
Cyp1a2		V							V
Gmppb		V		V	V				V
Gmppa		V			V					V
Tkfc		V				V			V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Nat8		V							V
Pi4kb		V								V
Pik3c2a		V					V		V
Mtmr4		V			V		V		V
Ddc		V							V
Keg1		V	V						V
Cad		V			V				V
Sdsl		V			V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Pnp		V								V
Pnp2		V								V
Entpd8		V							V
Nme6		V							V
Cant1		V								V
Aprt		V			V				V	V
Pfkfb3		V			V		V			V
Elovl1		V		V	V			V	V	V
Cyp2c40		V							V
Cyp3a11		V		V					V
Cyp2c70		V	V						V
Cyp2c68		V							V
Cyp2c55		V							V
Papss1		V			V	V			V	V
Comt		V				V			V
Ugdh		V							V
Gfpt1		V
Asns		V				V				V
Acmsd		V							V
Acsl4		V							V
Sqle		V						V	V
Lss		V		V					V
Tm7sf2		V							V
Hsd17b2		V							V
Cyp2r1		V			V				V
Csad		V				V	V		V	V
Cyp4a12b		V							V
Cyp4a12a		V							V
Idi1		V							V
Fdps		V		V					V
Alg8		V			V					V
St6gal1		V			V				V
Galnt18		V								V
St3gal1		V							V
St3gal5		V							V
Coq7		V								V
Dhrs9		V			V			V	V
Gcnt4		V							V
St3gal4		V							V
H6pd		V	V							V
Nsd3		V						V	V	V
Crls1			V			V				V
Pten			V			V				V
Pik3c3			V			V				V
Afmid			V		V			V	V
Bcat2			V			V			V	V
Ugt2b34			V						V
Cda			V
Nudt16			V							V
Mocs1			V
Mgat1			V		V					V
Cyp2c54			V						V
Cyp7a1			V						V
Acsl1			V		V				V	V
Slc27a5			V						V
Urad			V						V
Sirt3			V			V	V
Naga			V	V	V					V
Slc33a1			V						V
Acot5			V
Acot1			V
Ampd2			V		V					V
Cox5a			V
Ndufs2			V	V	V	V	V	V	V	V
Ndufab1			V			V				V
Ezh2			V							V
Msmo1				V					V
Gsta1				V					V
Gstm4				V					V	V
Pi4k2a				V	V			V	V
Tymp				V
Acacb				V		V			V	V
Alg2				V	V
Elovl3				V	V				V
Srm				V
Hmgcs1				V	V				V
Lpin1				V	V				V
Pgd				V						V
Ass1				V	V				V
Cdo1				V		V	V			V
Dnmt3a				V	V			V	V	V
Tat				V					V
Hpd				V					V
Hal				V					V
Acsl3				V					V
Mvd				V	V			V	V
Hsd17b7				V	V				V
Sc5d				V	V			V	V
Tkt				V		V				V
Me1				V						V
Pcyt2				V		V			V
Phospho1				V	V				V
Nnt				V
Galnt11				V			V
Dpagt1				V		V			V
Rdh11				V					V
Pigs				V	V					V
Mocs2				V	V	V	V			V
Hmgcr				V					V
Acly				V		V				V
Atp5d				V		V
Hexa					V					V
Man1c1					V			V		V
Sgpl1					V			V
Arg1					V				V
Hadha					V				V	V
Pdxk					V
Phospho2					V	V
Pld4					V				V	V
Pld3					V
Hsd17b12					V	V				V
Hacd4					V					V
Glyctk					V				V
Glb1					V					V
Rrm1					V					V
Rrm2					V				V
Hpgds					V			V		V
Ggt6					V
Anpep					V			V	V
Aldh3b1					V
Hk3					V			V
Pik3cd					V
Pik3cg					V					V
Inpp5d					V			V		V
Pi4k2b					V			V	V
Pip5k1c					V				V
Ocrl					V
Inpp4b					V
Mtmr6					V					V
Itpk1					V			V
Pip4k2b					V
Pip4k2a					V			V		V
Plcg2					V			V		V
Itpkb					V					V
Cdipt					V					V
Maoa					V					V
Gatm					V			V
Cndp2					V					V
Got1					V				V
Ldha					V				V
Enpp1					V				V
Upp1					V
Dck					V					V
Nt5c2					V			V	V	V
Entpd1					V			V		V
Pde1b					V					V
Pde8a					V
Pde2a					V					V
Pde7b					V
Adcy3					V					V
Adcy7					V
Entpd5					V				V
Ada					V
Dera					V				V
Oxct1					V					V
Acss1					V					V
Renbp					V					V
B3gnt3					V					V
Gcnt2					V				V	V
Mgat5					V
B4galt5					V				V
Hmox1					V			V		V
Blvra					V					V
Gusb					V			V		V
Large1					V					V
Idua					V		V			V
Dhcr24					V				V
Sms					V			V		V
Sms-ps					V			V		V
Ak1					V		V			V
Akr1b3					V					V
Akr1b8					V					V
Xylt2					V					V
Xylt1					V			V		V
Dgkz					V			V		V
Lpin3					V					V
Acads					V					V
Mthfd2					V			V		V
Mthfd1l					V
Gnpda1					V
Nans					V					V
Aldh18a1					V					V
Sat1					V					V
Acat2					V	V				V
Acsl5					V					V
Gapdh-ps15					V				V
Gapdh					V				V
Pla2g2e					V					V
Pisd					V	V
Agps					V					V
Pafah2					V				V	V
Pafah1b2					V					V
Pla2g7					V			V		V
Sgms1					V					V
Smpd4					V			V
Galc					V			V		V
Asah1					V					V
Sptlc3					V
Ltc4s					V					V
Tbxas1					V					V
Mgll					V					V
Dad1					V					V
Galnt7					V			V
Galnt1					V		V			V
Galnt6					V			V
Galnt12					V					V
Chpf					V					V
Gba					V					V
B4galt6					V					V
B4galnt1					V			V	V
St6galnac4					V					V
Pcx					V	V
Prps1					V					V
Tpi1					V				V	V
Galns					V			V		V
Ndst1					V				V
Hpse					V
Aldh1a2					V					V
Dhrs3					V					V
Hyal1					V				V
Pigt					V					V
Gcnt1					V					V
Csgalnact1					V					V
Ampd3					V					V
Adssl1					V				V
Ak6					V			V		V
Acp2					V			V	V	V
Npl					V					V
G6pdx					V					V
Pycr1					V					V
Cox6a2					V
Atp6v0b					V					V
Atp6v1a					V			V
Atp6v1b2					V			V		V
Atp6v0a1					V			V		V
Atp6v0c					V					V
Atp6v0d2					V			V
Tcirg1					V			V	V
Atp6ap1					V					V
Atp6v1c1					V
Acer3					V
Dot1l					V			V		V
Kmt5a					V					V
Setd7					V					V
Plod1					V					V
Plod2					V					V
Colgalt1					V			V	V
Mcat						V				V
Mecr						V	V			V
Sdha						V				V
Sdhb						V				V
Echs1						V			V	V
Xdh						V		V		V
Tgds						V				V
Bckdha						V				V
Dbt						V	V
Tecr						V				V
Elovl6						V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Gpx3						V				V
Gpx4						V				V
Gpx8						V				V
Aldh7a1						V			V
Plcd1						V				V
Itpka						V				V
Alas2						V	V		V
Ldhb						V	V			V
Gcat						V			V
Ddo						V
Ugt1a7c						V				V
Ugt1a5						V			V
Nt5e						V				V
Dtymk						V				V
Pde3b						V	V			V
Nme3						V				V
Npr2						V				V
Gucy1a1						V				V
Tst						V			V
Mpst						V			V	V
Shpk						V			V
L2hgdh						V			V
Aacs						V				V
Grhpr						V			V
Pfkfb1						V
Khk						V			V
Pdha1						V				V
Pdhx						V				V
Pdhb						V				V
Cept1						V				V
B4galt1						V				V
Galt						V	V
Amy1						V	V		V	V
Phykpl						V
Chdh						V
Hmgcs2						V			V
Fah						V	V		V
Aldh6a1						V	V			V
Hibadh						V
Hibch						V	V			V
Acadsb						V				V
Acad8						V			V
Aco2						V	V			V
Tdo2						V			V
Fdft1						V			V
Galk1						V
Gmds						V				V
Fahd1						V			V
Aldh5a1						V			V
Phgdh						V	V			V
Ckmt1						V				V
Adh1						V	V		V
Azin2						V	V			V
Mccc2						V				V
Acadvl						V			V
Ppt2						V				V
Cyp27a1						V			V
Amacr						V			V
Gpt2						V			V
Ctps2						V	V	V		V
Dpyd						V			V
Sephs2						V			V
Pla2g2d						V				V
Pla2g12a						V				V
Agpat3						V
Agpat1						V				V
Gpat4						V			V	V
Alox5						V				V
Ptges						V				V
Ptges2						V				V
Alox15						V				V
Cbr2						V				V
Cyp2e1						V	V			V
Sirt4						V				V
Naprt						V			V	V
Pnpla2						V	V			V
Trit1						V	V			V
Man2a2						V				V
Galnt10						V				V
Chpf2						V				V
Pigp						V				V
St3gal6						V				V
B3galt2						V	V			V
St6galnac5						V				V
Pnpo						V	V		V
Acyp1						V				V
Eno3						V				V
Pck1						V	V
Taldo1						V	V			V
Mpi						V
Hgsnat						V			V	V
Idh3g						V	V			V
Suclg2						V			V
Suclg1						V			V
Nampt						V				V
Gys1						V				V
Pygb						V	V			V
Alad						V	V		V
Hmbs						V				V
Adk						V			V
Acp5						V	V	V		V
Dguok						V				V
Isyna1						V				V
Pccb						V				V
Sqor						V				V
Uqcrq						V				V
Uqcr10						V
Uqcr11						V
Uqcrc2						V			V
Cox6a1						V				V
Cox6c						V				V
Cox7a2						V			V	V
Cox7c						V
COX2						V
COX3						V
Atp6v0e2						V				V
Cyc1						V	V			V
Uqcrfs1						V				V
Ndufb11						V
ND3						V
Ndufa2						V				V
Ndufa4						V			V	V
Ndufv1						V
Ndufs1						V	V		V	V
Ndufs6						V			V	V
Ndufa1						V
Ndufa3						V
Ndufb9						V				V
Ndufc1						V				V
Ndufa12						V				V
Ndufa6						V			V	V
Ndufb8						V				V
Ndufa10						V				V
Ndufc2						V		V		V
Ndufb2						V
Ndufa5						V
Ndufb10						V				V
Ndufs3						V			V	V
Ndufs7						V	V			V
Ndufv3						V				V
Ezh1						V				V
Camkmt						V				V
Lipt1							V
Acox3							V		V
Synj1							V
Mtmr14							V			V
Plce1							V			V
Ugt1a1							V		V
Adh5							V		V
Mcee							V			V
Dpm1							V			V
Mgat4b							V			V
Pomgnt1							V			V
Fut8							V			V
Nat8l							V			V
Psat1							V			V
Apip							V			V
Plaat3							V			V
Alg9							V			V
Gart							V
Pcbd1							V		V
Cox7a1							V
Atp6v0a2							V			V
Atp5g3							V
Smyd1							V
Ehmt1							V
Setd2							V			V
Impdh2								V		V
Gatb								V	V	V
Ahcyl1								V		V
Amdhd2								V
Man1a									V
Acsm1									V
Cth									V
Ppat									V
Elovl2									V
Hacd3									V
Scd3									V
Aldoc									V
Aldob									V
Shmt2									V
Shmt1									V
Mthfr									V
Agxt									V
Agxt2									V
Gstm6									V
Gsto1									V
Gstm7									V
Lap3									V
Nat8f1									V
Nat8f2									V
Sepsecs									V	V
Pah									V
G6pc									V
Inppl1									V	V
Mtmr1									V
Inpp5k									V	V
Cat									V
Aadat									V
Kynu									V
Glyat									V
Mif									V
Aspdh									V
Abat									V
Got2									V
Gss									V
Nit2									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Dpys									V
Upb1									V
Umps									V
Adcy9									V
Pde9a									V
Paics									V
Rbks									V
Hoga1									V
Ldhd									V
Glo1									V
Acot12									V
Dpm2									V	V
Acaa2									V
Cyp8b1									V
Chac2									V
Blvrb									V
B3galnt2									V
Srr									V
Gclc									V
Gclm									V
Gldc									V
Cyp26a1									V
Cyp2a12									V
Cyp2a5									V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp3a13									V
Cyp2c23									V
Cyp3a25									V
Ak2									V	V
Etnppl									V
Gulo									V
Bpnt1									V
Cbs									V
Hsd3b5									V
Mthfd1									V
Btd									V
Pgk1									V
Cryl1									V	V
Nanp									V
Tsta3									V
Rgn									V
Mat2b									V
Mat1a									V
Adi1									V
Amd1									V
Pipox									V
Otc									V
Hgd									V
Adh4									V
Aldh8a1									V
Cps1									V
Ftcd									V
Amdhd1									V
Uroc1									V
Bhmt2									V
Dmgdh									V
Hmgcl									V
Bdh2									V
Bdh1									V
Ebp									V
Hsd3b7									V
Acox2									V
Cyp21a1									V
Hsd17b6									V
Gpt									V	V
Baat									V
Pla2g12b									V
Pemt									V
Cyp2j5									V
Cyp2j6									V
Cyp4a32									V
Cyp4a10									V
Cyp4a14									V
Cyp4a31									V
Ephx2									V
Cyp4f14									V
Qprt									V
Sirt7									V	V
Nadk									V	V
Lipc									V
Ganab									V
Man2a1									V
Chsy3									V
St6galnac6									V
Urod									V
Sphk2									V	V
Aass									V
Hao1									V
Acsm5									V
Nags									V
Adpgk									V
Glud1									V
Agmat									V
Sord									V
Kmo									V
Gns									V
Bco1									V
Rdh7									V
Galm									V
Gm4737									V
Ahcy									V
Gpld1									V
Pygl									V
Agl									V
B4galt7									V
B3gat3									V
Ggcx									V
Spr									V
Gch1									V
Urah									V
Nat2									V
Flad1									V	V
Mthfsl									V
Mthfs									V
Gphn									V
Gnpnat1									V
Gnmt									V
Sardh									V
Ethe1									V
P4ha2									V	V
Acot8									V
Atp6v1h									V	V
Ndufa7									V	V
Ehmt2									V	V
Prdm2									V
Setd1b									V
Setdb1									V
Kmt5c									V	V
Bbox1									V
Plod3									V	V
Man1b1										V
Lias										V
Lipt2										V
Neu1										V
Neu3										V
Cbr4										V
Sdhc										V
Pdxp										V
Pld2										V
Dld										V
Hacd1										V
Hacd2										V
Scd2										V
Rrm2b										V
Gstm2										V
Ggt7										V
Ggt5										V
Gsr										V
Gpx7										V
Oplah										V
Gls										V
Mars1										V
Mtr										V
Aldh1a3										V
Aldh3b2										V
Aoc3										V
Aoc2										V
Pgm2										V
Hk1										V
Hk2										V
G6pc3										V
Pi4ka										V
Pip5k1b										V
Inpp5e										V
Mtm1										V
Mtmr2										V
Fig4										V
Pip4k2c										V
Plcg1										V
Plcd3										V
Inpp5j										V
Inpp5a										V
Inpp1										V
Aspa										V
Nos2										V
Nos3										V
Bcat1										V
Ugt1a6b										V
Nudt2										V
Nt5m										V
Nt5c										V
Nt5c3b										V
Fhit										V
Enpp4										V
Pde7a										V
Pde3a										V
Adcy4										V
Adcy5										V
Itpa										V
Nme7										V
Gmpr2										V
Gmpr										V
Hddc3										V
Pde6d										V
Pde5a										V
Gucy1b1										V
Pkm										V
Guk1										V
Impdh1										V
Atic										V
Entpd2										V
Ntpcr										V
Adsl										V
Nudt5										V
Adprm										V
Nudt9										V
Car7										V
Mdh2										V
Pgm2l1										V
Dpm3										V
Hadhb										V
B3gat2										V
Alg11										V
Alg14										V
Alg1										V
Alg5										V
Mgat3										V
Dlat										V
B3galnt1										V
Rxylt1										V
St3gal3										V
Pomk										V
Fkrp										V
B4gat1										V
B4galt2										V
A4galt										V
Ids										V
Smox										V
Cyp2s1										V
Ak5										V
Acp1										V
Folh1										V
Pfkl										V
Pfkm										V
Pfkp										V
Dgka										V
Plpp1										V
Plpp3										V
Mthfd2l										V
Uap1										V
Uap1l1										V
Akr1a1										V
Uxs1										V
Gfpt2										V
Gnpda2										V
Pmm1										V
Mat2a										V
Ckb										V
Hdc										V
Psph										V
Gstz1										V
Asrgl1										V
Sat2										V
Mtap										V
Auh										V
Ppt1										V
Acsbg1										V
Mvk										V
Lbr										V
Rpia										V
Rpe										V
Dhodh										V
Cmpk2										V
Uckl1										V
Pla2g4a										V
Pgs1										V
Mboat1										V
Agpat5										V
Agpat4										V
Ptdss2										V
Agk										V
Lpcat1										V
Lpcat4										V
Kdsr										V
Smpd1										V
Smpd3										V
Cers4										V
Cers5										V
Sptlc2										V
Sptlc1										V
Cyp2j9										V
Ptgs1										V
Prxl2b										V
Cbr3										V
Ptgis										V
Ptgds										V
Cd38										V
Pnpla3										V
Dgat2										V
Dolk										V
Ddost										V
Stt3b										V
Tusc3										V
Galnt2										V
Galnt16										V
Galnt17										V
Galnt15										V
St3gal2										V
Chsy1										V
Pigh										V
Pigq										V
Pigc										V
Gba2										V
B4galt4										V
B3galt4										V
Sphk1										V
Acyp2										V
Pgp										V
Eno2										V
Lta4h										V
Pck2										V
Dut										V
Idnk										V
Prps2										V
Alg12										V
Coq2										V
Coq3										V
Coq6										V
Coq5										V
Ext2										V
Naglu										V
Idh2										V
Idh3a										V
Ogdhl										V
Rdh12										V
Arsb										V
Enoph1										V
Pigl										V
Pigm										V
Pigx										V
Pigf										V
Gpaa1										V
Pygm										V
Vkorc1										V
Vkorc1l1										V
Rfk										V
Pcca										V
Echdc1										V
Pycr2										V
P4ha1										V
Cs										V
Uqcrc1										V
Cox6b1										V
Cox17										V
Cox8a										V
Cox8b										V
Cox7a2l										V
Cox6b2										V
Cox4i2										V
Atp5c1										V
Atp5pb										V
Atp6v0d1										V
Atp6v1e1										V
Atp6v1f										V
Atp6v1g2										V
Atp6v1g1										V
Atp6v1d										V
Ndufb4c										V
Ndufb4b										V
Ndufb4										V
ND2										V
Ndufa4l2										V
Ndufs5										V
Ndufb5										V
Ndufb3										V
Ndufb7										V
Ndufv2										V
Smyd2										V
Smyd3										V
Kmt2b										V
+ 01200: Carbon metabolism	3.2	0.5	0.2	1.9	1	4.5	3.2	0.2	5.6	3.1
Fbp1	V								V
Gck	V			V					V
Pgls	V					V				V
Pklr	V								V
Idh1	V								V
Acat1	V
Sds	V								V
Esd	V								V
Acox1	V							V	V	V
Acss2	V			V		V				V
Hao2	V
H6pd		V	V							V
Sdsl		V			V
Tkfc		V				V			V
Tkt				V		V				V
Pgd				V						V
Me1				V						V
Gapdh-ps15					V				V
Gapdh					V				V
Hk3					V			V
G6pdx					V					V
Tpi1					V				V	V
Acat2					V	V				V
Glyctk					V				V
Prps1					V					V
Pcx					V	V
Acads					V					V
Hadha					V				V	V
Got1					V				V
Acss1					V					V
Taldo1						V	V			V
Eno3						V				V
Pdha1						V				V
Pdhb						V				V
Sdha						V				V
Sdhb						V				V
Suclg2						V			V
Suclg1						V			V
Idh3g						V	V			V
Aco2						V	V			V
Pccb						V				V
Phgdh						V	V			V
Echs1						V			V	V
Hibch						V	V			V
Aldh6a1						V	V			V
Gpt2						V			V
Mcee							V			V
Psat1							V			V
Adh5							V		V
Acox3							V		V
Aldoc									V
Aldob									V
Pgk1									V
Adpgk									V
Agxt									V
Shmt2									V
Shmt1									V
Mthfr									V
Gldc									V
Cps1									V
Rgn									V
Got2									V
Gpt									V	V
Glud1									V
Cat									V
Hao1									V
Rpe										V
Pfkl										V
Pfkm										V
Pfkp										V
Hk1										V
Hk2										V
Rpia										V
Eno2										V
Pkm										V
Dld										V
Dlat										V
Cs										V
Mdh2										V
Sdhc										V
Idh2										V
Idh3a										V
Pcca										V
Psph										V
Prps2										V
Ogdhl										V
Me2										V
Idnk										V
Pgp										V
+ 01210: 2-Oxocarboxylic acid metabolism	0.8	0	1.2	0	0.2	2.2	1.8	0	3.6	1.4
Idh1	V								V
Bcat2			V			V			V	V
Got1					V				V
Gpt2						V			V
Aco2						V	V			V
Idh3g						V	V			V
Got2									V
Gpt									V	V
Nags									V
Aadat									V
Cs										V
Idh2										V
Idh3a										V
Bcat1										V
+ 01212: Fatty acid metabolism	5.9	1.2	0.5	4	1.8	4.2	0.7	1.1	4.8	2.6
Fasn	V			V		V				V
Acat1	V
Acaa1a	V								V	V
Acaa1b	V			V					V
Hadh	V
Fads2	V								V
Elovl5	V			V					V
Fads1	V							V	V
Scp2	V	V		V		V			V
Acox1	V							V	V	V
Acaca	V					V
Cpt1a	V				V				V
Acadm	V									V
Acsf3	V					V				V
Elovl1		V		V	V			V	V	V
Acsl4		V							V
Acsl1			V		V				V	V
Elovl3				V	V				V
Acsl3				V					V
Hsd17b12					V	V				V
Hacd4					V					V
Acat2					V	V				V
Hadha					V				V	V
Acads					V					V
Acsl5					V					V
Mcat						V				V
Mecr						V	V			V
Elovl6						V
Tecr						V				V
Echs1						V			V	V
Acadsb						V				V
Acadvl						V			V
Ppt2						V				V
Acox3							V		V
Hacd3									V
Acaa2									V
Scd3									V
Elovl2									V
Cbr4										V
Hacd1										V
Hacd2										V
Hadhb										V
Cpt2										V
Scd2										V
Acsbg1										V
Cpt1c										V
Ppt1										V
+ 01230: Biosynthesis of amino acids	1.7	0.5	0.4	1.5	1.5	2.6	2	0	5.8	1.9
Pklr	V								V
Sds	V								V
Idh1	V								V
Asl	V								V
Glul	V					V				V
Sdsl		V			V
Asns		V				V				V
Bcat2			V			V			V	V
Tkt				V		V				V
Ass1				V	V				V
Tat				V					V
Tpi1					V				V	V
Gapdh-ps15					V				V
Gapdh					V				V
Prps1					V					V
Got1					V				V
Pcx					V	V
Arg1					V				V
Aldh18a1					V					V
Pycr1					V					V
Eno3						V				V
Phgdh						V	V			V
Aco2						V	V			V
Idh3g						V	V			V
Gpt2						V			V
Taldo1						V	V			V
Psat1							V			V
Pgk1									V
Aldoc									V
Aldob									V
Shmt2									V
Shmt1									V
Got2									V
Cth									V
Gpt									V	V
Nags									V
Otc									V
Cps1									V
Pah									V
Mat2b									V
Mat1a									V
Cbs									V
Eno2										V
Pkm										V
Pfkl										V
Pfkm										V
Pfkp										V
Rpe										V
Rpia										V
Prps2										V
Bcat1										V
Psph										V
Mtr										V
Cs										V
Idh2										V
Idh3a										V
Pycr2										V
Mat2a										V
+ 1.1 Carbohydrate metabolism	8.9	3.1	1.3	4.7	4.4	9.9	5	1.8	11.4	5.6
+ 00010: Glycolysis / Gluconeogenesis	3.7	0	0	1.6	0.9	2.6	1.7	0.2	4.2	1.2
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Pklr	V								V
Fbp1	V								V
Pgm1	V					V				V
Gck	V			V					V
Acss2	V			V		V				V
Aldh3b1					V
Ldha					V				V
Gapdh-ps15					V				V
Gapdh					V				V
Tpi1					V				V	V
Hk3					V			V
Acss1					V					V
Aldh7a1						V			V
Adh1						V	V		V
Pdha1						V				V
Pdhb						V				V
Ldhb						V	V			V
Eno3						V				V
Pck1						V	V
Adh5							V		V
Aldoc									V
Aldob									V
Adh4									V
Galm									V
G6pc									V
Pgk1									V
Adpgk									V
Aldh1a3										V
Aldh3b2										V
Akr1a1										V
Dlat										V
Pkm										V
Eno2										V
Pfkl										V
Pfkm										V
Pfkp										V
Pgm2										V
Hk1										V
Hk2										V
G6pc3										V
Dld										V
Pck2										V
+ 00020: Citrate cycle (TCA cycle)	0.5	0	0	0.8	0	4.7	2	0	0.4	2.5
Idh1	V								V
Acly				V		V				V
Pcx					V	V
Suclg2						V			V
Suclg1						V			V
Idh3g						V	V			V
Aco2						V	V			V
Pdha1						V				V
Pdhb						V				V
Pck1						V	V
Sdha						V				V
Sdhb						V				V
Dld										V
Ogdhl										V
Idh2										V
Idh3a										V
Cs										V
Mdh2										V
Dlat										V
Pck2										V
Sdhc										V
+ 00030: Pentose phosphate pathway	1.8	0.6	0.9	1.6	0.9	1.4	0.6	0	1.9	2.3
Fbp1	V								V
Pgls	V					V				V
Pgm1	V					V				V
H6pd		V	V							V
Tkt				V		V				V
Pgd				V						V
Dera					V				V
Prps1					V					V
G6pdx					V					V
Glyctk					V				V
Taldo1						V	V			V
Rbks									V
Aldoc									V
Aldob									V
Rgn									V
Pgm2										V
Prps2										V
Rpia										V
Rpe										V
Pfkl										V
Pfkm										V
Pfkp										V
Idnk										V
+ 00040: Pentose and glucuronate interconversions	1.7	2.5	0.9	0	0.4	1.4	0.5	0.5	5.6	0.2
Dcxr	V								V
Ugp2	V					V			V
Dhdh	V					V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Ugdh		V							V
Ugt2b34			V						V
Gusb					V			V		V
Akr1b3					V					V
Akr1b8					V					V
Ugt1a7c						V				V
Ugt1a5						V			V
Ugt1a1							V		V
Cryl1									V	V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Sord									V
Rpe										V
Ugt1a6b										V
Akr1a1										V
+ 00051: Fructose and mannose metabolism	0.4	2.5	0	0.8	2.3	1.8	0.5	0.5	2.5	1.1
Fbp1	V								V
Pfkfb3		V			V		V			V
Gmppb		V		V	V				V
Gmppa		V			V					V
Tkfc		V				V			V
Akr1b3					V					V
Akr1b8					V					V
Hk3					V			V
Pfkfb4					V					V
Tpi1					V				V	V
Khk						V			V
Pfkfb1						V
Mpi						V
Gmds						V				V
Sord									V
Tsta3									V
Aldoc									V
Aldob									V
Hk1										V
Hk2										V
Pmm1										V
Pfkl										V
Pfkm										V
Pfkp										V
+ 00052: Galactose metabolism	2.4	0	0	1.7	0.9	2	0.6	0.5	0.7	1.8
Gaa	V			V						V
Gck	V			V					V
Pgm1	V					V				V
Ugp2	V					V			V
Akr1b3					V					V
Akr1b8					V					V
Hk3					V			V
Glb1					V					V
B4galt1						V				V
Galt						V	V
Galk1						V
G6pc									V
Galm									V
Pfkl										V
Pfkm										V
Pfkp										V
Hk1										V
Hk2										V
Pgm2										V
B4galt2										V
G6pc3										V
+ 00053: Ascorbate and aldarate metabolism	2.6	2.8	1	0.9	0.1	1.7	0.7	0	7.2	0
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Ugdh		V							V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Ugt2b34			V						V
Ugt1a7c						V				V
Ugt1a5						V			V
Aldh7a1						V			V
Ugt1a1							V		V
Rgn									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Gulo									V
Ugt1a6b										V
+ 00500: Starch and sucrose metabolism	4	0	0	1.6	0.2	1.9	1.2	0.5	2.6	0.7
Gaa	V			V						V
Enpp3	V								V
Ugp2	V					V			V
Gys2	V								V
Pgm1	V					V				V
Gck	V			V					V
Treh	V
Hk3					V			V
Enpp1					V				V
Gys1						V				V
Amy1						V	V		V	V
Pygb						V	V			V
G6pc									V
Pygl									V
Agl									V
Hk1										V
Hk2										V
Pgm2l1										V
Pgm2										V
G6pc3										V
Pygm										V
+ 00520: Amino sugar and nucleotide sugar metabolism	2.9	2.1	0	2	2.4	1.7	0.9	1.4	2.1	1.8
Nagk	V									V
Gne	V								V
Hexb	V									V
Pgm1	V					V				V
Ugp2	V					V			V
Gck	V			V					V
Gfpt1		V
Ugdh		V							V
Gmppb		V		V	V				V
Gmppa		V			V					V
Cyb5r3				V	V		V		V
Nans					V					V
Gnpda1					V
Renbp					V					V
Hexa					V					V
Npl					V					V
Hk3					V			V
Cyb5r1					V					V
Galt						V	V
Mpi						V
Galk1						V
Gmds						V				V
Amdhd2								V
Cyb5rl								V
Nanp									V
Gnpnat1									V
Cyb5r4									V	V
Tsta3									V
Uap1										V
Uap1l1										V
Gnpda2										V
Gfpt2										V
Hk1										V
Hk2										V
Uxs1										V
Pmm1										V
Pgm2										V
+ 00620: Pyruvate metabolism	4.8	0	0	2.9	1	5.5	1.8	0	3.4	2.2
Pklr	V								V
Hagh	V					V	V		V	V
Acss2	V			V		V				V
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Acat1	V
Acaca	V					V
Me1				V						V
Acacb				V		V			V	V
Pcx					V	V
Ldha					V				V
Acss1					V					V
Acat2					V	V				V
Pdha1						V				V
Pdhb						V				V
Pck1						V	V
Ldhb						V	V			V
Aldh7a1						V			V
Grhpr						V			V
Acyp1						V				V
Glo1									V
Ldhd									V
Acot12									V
Pck2										V
Pkm										V
Me2										V
Mdh2										V
Dlat										V
Dld										V
Acyp2										V
+ 00630: Glyoxylate and dicarboxylate metabolism	2.5	0	0.9	0.8	0.9	2.5	1.3	0.5	3.3	1.3
Hao2	V
Acat1	V
Glul	V					V				V
Acss2	V			V		V				V
Afmid			V		V			V	V
Acat2					V	V				V
Glyctk					V				V
Acss1					V					V
Aco2						V	V			V
Grhpr						V			V
Pccb						V				V
Mcee							V			V
Hoga1									V
Hao1									V
Agxt									V
Shmt2									V
Shmt1									V
Gldc									V
Cat									V
Cs										V
Mdh2										V
Pgp										V
Pcca										V
Dld										V
+ 00640: Propanoate metabolism	3.5	0	0	1.6	1.2	5.4	4.3	0.5	3	3.2
Acaca	V					V
Acss3	V						V			V
Acss2	V			V		V				V
Acat1	V
Bckdhb	V								V	V
Acox1	V							V	V	V
Acacb				V		V			V	V
Acss1					V					V
Ldha					V				V
Hadha					V				V	V
Acads					V					V
Acat2					V	V				V
Aldh6a1						V	V			V
Hibch						V	V			V
Pccb						V				V
Ldhb						V	V			V
Echs1						V			V	V
Suclg2						V			V
Suclg1						V			V
Bckdha						V				V
Dbt						V	V
Mcee							V			V
Acox3							V		V
Abat									V
Pcca										V
Echdc1										V
Dld										V
+ 00650: Butanoate metabolism	2	0	0	0.9	1.5	3.2	0	0	4.8	0.3
Acat1	V
Hadh	V
Acsm3	V					V			V	V
Hmgcs1				V	V				V
Oxct1					V					V
Acat2					V	V				V
Hadha					V				V	V
Acads					V					V
Aacs						V				V
Hmgcs2						V			V
Echs1						V			V	V
Aldh5a1						V			V
L2hgdh						V			V
Bdh2									V
Bdh1									V
Hmgcl									V
Abat									V
Acsm1									V
Acsm5									V
+ 00562: Inositol phosphate metabolism	0.5	1.1	1.1	0.4	3.5	1.4	2.6	2.4	1.1	2.6
Ipmk	V								V
Pik3cb	V					V				V
Pi4kb		V								V
Mtmr4		V			V		V		V
Pik3c2a		V					V		V
Pten			V			V				V
Pik3c3			V			V				V
Pi4k2a				V	V			V	V
Pip4k2b					V
Pip4k2a					V			V		V
Ocrl					V
Itpkb					V					V
Itpk1					V			V
Inpp4b					V
Pi4k2b					V			V	V
Pip5k1c					V				V
Mtmr6					V					V
Plcg2					V			V		V
Pik3cd					V
Pik3cg					V					V
Tpi1					V				V	V
Cdipt					V					V
Inpp5d					V			V		V
Itpka						V				V
Isyna1						V				V
Plcd1						V				V
Aldh6a1						V	V			V
Synj1							V
Mtmr14							V			V
Plce1							V			V
Inpp5k									V	V
Mtmr1									V
Inppl1									V	V
Pip4k2c										V
Inpp5e										V
Inpp5j										V
Inpp5a										V
Inpp1										V
Mtm1										V
Pi4ka										V
Pip5k1b										V
Mtmr2										V
Plcg1										V
Plcd3										V
Fig4										V
+ 1.2 Energy metabolism	2.2	0.7	0.5	1.2	0.7	7.6	1.2	0.9	2.7	2.6
+ 00190: Oxidative phosphorylation	0.2	0	0.9	0.8	0.2	8.5	2.1	1.5	0.1	3.7
Cox4i1	V					V				V
Ndufa11	V			V						V
Ndufs8	V						V			V
Ndufab1			V			V				V
Ndufs2			V	V	V	V	V	V	V	V
Cox5a			V
Atp5d				V		V
Cox6a2					V
Atp6v0b					V					V
Atp6v1a					V			V
Atp6v1b2					V			V		V
Atp6v0a1					V			V		V
Atp6v0c					V					V
Atp6v0d2					V			V
Tcirg1					V			V	V
Atp6ap1					V					V
Atp6v1c1					V
Ndufc2						V		V		V
Ndufc1						V				V
Ndufb10						V				V
Ndufb9						V				V
Ndufb8						V				V
Ndufb2						V
Ndufa10						V				V
Ndufa6						V			V	V
Ndufa5						V
Ndufa4						V			V	V
Ndufa3						V
Ndufa2						V				V
Ndufa1						V
Ndufv3						V				V
Ndufv1						V
Ndufs7						V	V			V
Ndufs6						V			V	V
Ndufs3						V			V	V
Ndufs1						V	V		V	V
ND3						V
Ndufb11						V
Ndufa12						V				V
Cox7c						V
Cox7a2						V			V	V
Cox6c						V				V
Uqcrq						V				V
Uqcr10						V
Cyc1						V	V			V
Uqcr11						V
Uqcrfs1						V				V
Uqcrc2						V			V
Cox6a1						V				V
COX2						V
COX3						V
Atp6v0e2						V				V
Ppa1						V				V
Sdha						V				V
Sdhb						V				V
Cox7a1							V
Atp6v0a2							V			V
Atp5g3							V
Ndufa7									V	V
Atp6v1h									V	V
Lhpp									V
Cox4i2										V
Ndufb7										V
Ndufb5										V
Ndufb4c										V
Ndufb4b										V
Ndufb4										V
Ndufb3										V
Ndufa4l2										V
Ndufv2										V
Ndufs5										V
ND2										V
Cox17										V
Cox8a										V
Cox8b										V
Cox7a2l										V
Uqcrc1										V
Cox6b1										V
Cox6b2										V
Atp5c1										V
Atp5pb										V
Atp6v0d1										V
Atp6v1e1										V
Atp6v1f										V
Atp6v1g2										V
Atp6v1g1										V
Atp6v1d										V
Sdhc										V
+ 00910: Nitrogen metabolism	0.8	0	0	0	0	0.4	0	0	0.5	0
Glul	V					V				V
Cps1									V
Glud1									V
Car7										V
+ 00920: Sulfur metabolism	2.9	1.1	0	1.4	1	4.2	0	0	4.1	0.7
Suox	V					V			V
Papss2	V				V					V
Selenbp1	V			V		V			V
Papss1		V			V	V			V	V
Tst						V			V
Mpst						V			V	V
Sqor						V				V
Bpnt1									V
Ethe1									V
+ 1.3 Lipid metabolism	10.7	5.4	4.5	8.4	4.5	7.5	3.3	2.8	14.7	4.1
+ 00061: Fatty acid biosynthesis	2.3	0.8	1.2	2.9	0.6	3.3	0.9	0	1.4	1.6
Fasn	V			V		V				V
Acaca	V					V
Acsf3	V					V				V
Acsl4		V							V
Acsl1			V		V				V	V
Acacb				V		V			V	V
Acsl3				V					V
Acsl5					V					V
Mcat						V				V
Mecr						V	V			V
Acsbg1										V
Cbr4										V
+ 00062: Fatty acid elongation	3.1	0.6	3.4	2.5	1.4	3.6	0.6	0.6	3.3	2.1
Hadh	V
Acot2	V					V				V
Acot3	V		V
Acot4	V		V			V			V
Elovl5	V			V					V
Elovl1		V		V	V			V	V	V
Acot5			V
Acot1			V
Elovl3				V	V				V
Hadha					V				V	V
Hsd17b12					V	V				V
Hacd4					V					V
Ppt2						V				V
Mecr						V	V			V
Echs1						V			V	V
Tecr						V				V
Elovl6						V
Acaa2									V
Hacd3									V
Them4									V
Elovl2									V
Ppt1										V
Hadhb										V
Hacd1										V
Hacd2										V
Acot7										V
+ 00071: Fatty acid degradation	5.9	1.5	0.6	1.9	1.2	3.2	2.6	0.3	7.4	1.1
Hadh	V
Acadm	V									V
Eci2	V					V			V	V
Acat1	V
Acaa1a	V								V	V
Acaa1b	V			V					V
Gcdh	V								V
Acox1	V							V	V	V
Cpt1a	V				V				V
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Cyp4a12b		V							V
Cyp4a12a		V							V
Acsl4		V							V
Acsl1			V		V				V	V
Acsl3				V					V
Acads					V					V
Hadha					V				V	V
Acat2					V	V				V
Acsl5					V					V
Acadsb						V				V
Echs1						V			V	V
Eci1						V	V			V
Eci3						V	V			V
Adh1						V	V		V
Acadvl						V			V
Aldh7a1						V			V
Adh5							V		V
Acox3							V		V
Acaa2									V
Adh4									V
Cyp4a32									V
Cyp4a10									V
Cyp4a14									V
Cyp4a31									V
Hadhb										V
Acsbg1										V
Cpt1c										V
Cpt2										V
+ 00072: Synthesis and degradation of ketone bodies	1.1	0	0	1.4	1.7	1.4	0	0	2.8	0.1
Acat1	V
Hmgcs1				V	V				V
Acat2					V	V				V
Oxct1					V					V
Hmgcs2						V			V
Hmgcl									V
Bdh2									V
Bdh1									V
+ 00100: Steroid biosynthesis	0.7	3.8	0	5	3.1	0.3	0	3	5.2	0
Dhcr7	V	V		V	V				V
Tm7sf2		V							V
Lss		V		V					V
Cyp2r1		V			V				V
Sqle		V						V	V
Sc5d				V	V			V	V
Msmo1				V					V
Hsd17b7				V	V				V
Lipa				V	V			V	V
Dhcr24					V				V
Soat1					V			V		V
Fdft1						V			V
Ebp									V
Lbr										V
+ 00120: Primary bile acid biosynthesis	2.5	1.8	2.3	1.2	0	1.7	0	0	6.4	0
Cyp46a1	V
Akr1d1	V								V
Scp2	V	V		V		V			V
Cyp7b1		V							V
Cyp7a1			V						V
Slc27a5			V						V
Cyp27a1						V			V
Amacr						V			V
Acox2									V
Baat									V
Hsd3b7									V
Cyp8b1									V
Cyp39a1									V
Acot8									V
+ 00140: Steroid hormone biosynthesis	2.3	4.7	3.6	1.9	0	1.6	0.4	0	9.7	0
Cyp17a1	V								V
Hsd3b2	V		V						V
Cyp2c50	V			V					V
Cyp2c39	V								V
Cyp2d26	V								V
Akr1d1	V								V
Hsd11b1	V					V			V
Hsd17b2		V							V
Cyp7b1		V							V
Cyp1a2		V							V
Cyp2c40		V							V
Cyp3a11		V		V					V
Cyp2c70		V	V						V
Cyp2c68		V							V
Cyp2c55		V							V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Comt		V				V			V
Cyp2c54			V						V
Srd5a3			V	V						V
Srd5a2			V
Ugt2b34			V						V
Cyp7a1			V						V
Hsd17b7				V	V				V
Hsd17b12					V	V				V
Cyp2d22						V			V
Dhrs11						V			V
Ugt1a7c						V				V
Ugt1a5						V			V
Sult1e1						V				V
Cyp2e1						V	V			V
Ugt1a1							V		V
Hsd17b6									V
Cyp21a1									V
Hsd3b5									V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp2d10									V
Cyp2d9									V
Cyp3a13									V
Cyp2c23									V
Cyp2d11									V
Cyp3a25									V
Cyp2d40									V
Srd5a1									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Ugt1a6b										V
Cyp1b1										V
+ 00561: Glycerolipid metabolism	5.1	0.2	0	2.9	2.1	2.8	1.2	0.6	2.4	2.1
Lipg	V			V					V
Dgat1	V					V	V			V
Lpin2	V								V
Mogat1	V					V				V
Agpat2	V					V				V
Gpam	V			V
Gpat3	V									V
Gk	V				V				V
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Tkfc		V				V			V
Lpin1				V	V				V
Plpp5				V	V			V		V
Lpin3					V					V
Mogat2					V					V
Mgll					V					V
Akr1b3					V					V
Akr1b8					V					V
Dgkz					V			V		V
Glyctk					V				V
Pnpla2						V	V			V
Agpat3						V
Agpat1						V				V
Gpat4						V			V	V
Aldh7a1						V			V
Lpl							V		V	V
Lipc									V
Pnpla3										V
Dgat2										V
Plpp1										V
Plpp3										V
Mboat1										V
Agpat5										V
Agpat4										V
Agk										V
Akr1a1										V
Dgka										V
+ 00564: Glycerophospholipid metabolism	3.7	0.3	0.8	2.7	1.4	2.3	1.2	1.4	2.6	1.9
Lpcat3	V								V	V
Chpt1	V					V				V
Pcyt1a	V								V
Chkb	V							V		V
Etnk2	V								V
Pla2g6	V			V	V	V	V			V
Lpin2	V								V
Agpat2	V					V				V
Gpam	V			V
Gpat3	V									V
Lypla1	V								V
Etnk1		V							V
Pnpla7		V							V	V
Gpcpd1			V						V
Crls1			V			V				V
Pcyt2				V		V			V
Lpin1				V	V				V
Plpp5				V	V			V		V
Phospho1				V	V				V
Pla2g2e					V					V
Dgkz					V			V		V
Lpin3					V					V
Pld4					V				V	V
Pld3					V
Cdipt					V					V
Pisd					V	V
Pla2g15					V			V		V
Lpgat1					V				V
Cept1						V				V
Pla2g2d						V				V
Pla2g12a						V				V
Agpat3						V
Agpat1						V				V
Gpat4						V			V	V
Plaat3							V			V
Lypla2							V	V		V
Taz							V			V
Gnpat									V	V
Pla2g12b									V
Lcat									V
Pemt									V
Etnppl									V
Ptdss2										V
Lpcat1										V
Lpcat4										V
Pla2g4a										V
Dgka										V
Plpp1										V
Plpp3										V
Pld2										V
Mboat1										V
Agpat5										V
Agpat4										V
Gpd1										V
Adprm										V
Pgs1										V
+ 00565: Ether lipid metabolism	1.3	0	0	1.3	2.1	1.7	0.9	0.8	0.3	2.1
Chpt1	V					V				V
Pla2g6	V			V	V	V	V			V
Gal3st1	V
Enpp2				V		V				V
Agps					V					V
Pafah2					V				V	V
Pafah1b2					V					V
Pla2g7					V			V		V
Pla2g2e					V					V
Pld4					V				V	V
Pld3					V
Gdpd1					V			V		V
Cept1						V				V
Pla2g2d						V				V
Pla2g12a						V				V
Plaat3							V			V
Pla2g12b									V
Tmem86b									V
Plpp1										V
Plpp3										V
Pla2g4a										V
Lpcat1										V
Lpcat4										V
Pld2										V
Gdpd3										V
+ 00600: Sphingolipid metabolism	2.4	0.4	0	0.6	2.4	0	0	1.4	0.1	2.8
Asah2	V
Cers2	V								V	V
Smpd2	V									V
Gal3st1	V
Sgms2	V
Arsa		V		V					V	V
Acer3					V
Asah1					V					V
Smpd4					V			V
Sptlc3					V
Glb1					V					V
Gba					V					V
Sgpl1					V			V
Galc					V			V		V
B4galt6					V					V
Sgms1					V					V
Sphk2									V	V
Cers4										V
Smpd1										V
Smpd3										V
Cerk										V
Plpp1										V
Plpp3										V
Sptlc2										V
Sptlc1										V
Kdsr										V
Neu1										V
Neu3										V
Gba2										V
Sphk1										V
Cers5										V
+ 00590: Arachidonic acid metabolism	0.6	2.2	0.9	0.8	0.1	2.2	0.8	0.1	3.7	0.4
Cyp2c50	V			V					V
Cyp2c39	V								V
Pla2g6	V			V	V	V	V			V
Cyp2c40		V							V
Cyp2c70		V	V						V
Cyp2c68		V							V
Cyp2c55		V							V
Cyp4a12b		V							V
Cyp4a12a		V							V
Cyp2c54			V						V
Pla2g2e					V					V
Ltc4s					V					V
Tbxas1					V					V
Hpgds					V			V		V
Gpx3						V				V
Gpx8						V				V
Alox15						V				V
Pla2g2d						V				V
Pla2g12a						V				V
Alox5						V				V
Ptges						V				V
Ptges2						V				V
Cbr2						V				V
Cyp2e1						V	V			V
Plaat3							V			V
Ephx2									V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp2j5									V
Cyp2j6									V
Cyp2c23									V
Cyp4f14									V
Cyp4a32									V
Cyp4a10									V
Cyp4a14									V
Cyp4a31									V
Pla2g12b									V
Cyp2j9										V
Gpx7										V
Ptgs1										V
Pla2g4a										V
Lta4h										V
Ggt5										V
Ptgis										V
Ptgds										V
Cbr3										V
Prxl2b										V
+ 00591: Linoleic acid metabolism	1.3	3.1	1.4	1.9	0	1.2	1.5	0	4.6	0
Pla2g6	V			V	V	V	V			V
Cyp2c50	V			V					V
Cyp2c39	V								V
Cyp1a2		V							V
Cyp2c40		V							V
Cyp2c70		V	V						V
Cyp2c68		V							V
Cyp2c55		V							V
Cyp3a11		V		V					V
Cyp2c54			V						V
Pla2g2e					V					V
Alox15						V				V
Pla2g2d						V				V
Pla2g12a						V				V
Cyp2e1						V	V			V
Plaat3							V			V
Pla2g12b									V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp2c23									V
Cyp2j5									V
Cyp2j6									V
Cyp3a13									V
Cyp3a25									V
Pla2g4a										V
Cyp2j9										V
+ 00592: alpha-Linolenic acid metabolism	3.3	0	0	1.8	0.4	1.2	2.2	0.6	1.9	0.6
Acox1	V							V	V	V
Acaa1a	V								V	V
Acaa1b	V			V					V
Pla2g6	V			V	V	V	V			V
Fads2	V								V
Pla2g2e					V					V
Pla2g2d						V				V
Pla2g12a						V				V
Acox3							V		V
Plaat3							V			V
Pla2g12b									V
Pla2g4a										V
+ 01040: Biosynthesis of unsaturated fatty acids	5.6	1.3	3.3	3.7	0.9	2.4	0.6	1.8	5	0.8
Fads2	V								V
Acaa1a	V								V	V
Scp2	V	V		V		V			V
Acaa1b	V			V					V
Acox1	V							V	V	V
Acot2	V					V				V
Acot3	V		V
Acot4	V		V			V			V
Elovl5	V			V					V
Fads1	V							V	V
Elovl1		V		V	V			V	V	V
Acot5			V
Acot1			V
Elovl3				V	V				V
Hsd17b12					V	V				V
Hacd4					V					V
Tecr						V				V
Elovl6						V
Acox3							V		V
Elovl2									V
Hacd3									V
Baat									V
Scd3									V
Hacd1										V
Hacd2										V
Acot7										V
Scd2										V
+ 1.4 Nucleotide metabolism	3.6	3.4	1.6	0.8	3.8	2.4	0.5	1.9	3.2	4.2
+ 00230: Purine metabolism	1.9	1.9	1	0	2.7	1.1	0.4	0.9	1.6	3.9
Adcy6	V					V				V
Nme2	V									V
Gda	V
Uox	V								V
Papss2	V				V					V
Pklr	V								V
Pgm1	V					V				V
Enpp3	V								V
Entpd8		V							V
Nme6		V							V
Aprt		V			V				V	V
Pnp		V								V
Pnp2		V								V
Cant1		V								V
Papss1		V			V	V			V	V
Ampd2			V		V					V
Urad			V						V
Nudt16			V							V
Rrm1					V					V
Rrm2					V				V
Prps1					V					V
Pde1b					V					V
Pde2a					V					V
Adcy3					V					V
Adcy7					V
Entpd1					V			V		V
Ak6					V			V		V
Ak1					V		V			V
Adssl1					V				V
Ampd3					V					V
Nt5c2					V			V	V	V
Ada					V
Entpd5					V				V
Dck					V					V
Pde8a					V
Pde7b					V
Enpp1					V				V
Xdh						V		V		V
Pde3b						V	V			V
Nme3						V				V
Nt5e						V				V
Adk						V			V
Npr2						V				V
Gucy1a1						V				V
Dguok						V				V
Gart							V
Impdh2								V		V
Ppat									V
Paics									V
Adcy9									V
Ak2									V	V
Urah									V
Pde9a									V
Rrm2b										V
Prps2										V
Atic										V
Adsl										V
Pde3a										V
Adcy4										V
Adcy5										V
Entpd2										V
Nme7										V
Ak5										V
Nt5m										V
Nt5c										V
Nt5c3b										V
Gmpr2										V
Gmpr										V
Impdh1										V
Guk1										V
Hddc3										V
Gucy1b1										V
Pde6d										V
Pde5a										V
Itpa										V
Nudt2										V
Pgm2										V
Nudt5										V
Adprm										V
Nudt9										V
Fhit										V
Enpp4										V
Pkm										V
Ntpcr										V
Pde7a										V
+ 00240: Pyrimidine metabolism	3.1	2.9	1.3	1.2	2.7	2.2	0.3	1.7	3	2
Nme2	V									V
Cmpk1	V				V
Uck1	V					V				V
Upp2	V		V			V			V	V
Tk1	V				V				V
Tk2	V			V	V	V		V
Enpp3	V								V
Cad		V			V				V
Nme6		V							V
Entpd8		V							V
Cant1		V								V
Pnp		V								V
Pnp2		V								V
Cda			V
Tymp				V
Rrm1					V					V
Rrm2					V				V
Entpd1					V			V		V
Entpd5					V				V
Nt5c2					V			V	V	V
Upp1					V
Dck					V					V
Enpp1					V				V
Nme3						V				V
Ctps2						V	V	V		V
Nt5e						V				V
Dpyd						V			V
Dtymk						V				V
Umps									V
Dpys									V
Upb1									V
Rrm2b										V
Nme7										V
Cmpk2										V
Uckl1										V
Nt5m										V
Nt5c										V
Nt5c3b										V
Dhodh										V
Nudt2										V
Dut										V
+ 1.5 Amino acid metabolism	11.1	2.5	2.5	5.7	3.7	7.4	3.2	1.7	16.3	2.8
+ 00250: Alanine, aspartate and glutamate metabolism	2.2	1.8	0	2.3	0.7	1.7	0.5	0	5.3	0.5
Asl	V								V
Glul	V					V				V
Gls2	V			V					V
Aldh4a1	V			V						V
Asns		V				V				V
Cad		V			V				V
Gfpt1		V
Ass1				V	V				V
Got1					V				V
Adssl1					V				V
Ddo						V
Gpt2						V			V
Aldh5a1						V			V
Nat8l							V			V
Nit2									V
Got2									V
Agxt									V
Agxt2									V
Gpt									V	V
Glud1									V
Abat									V
Cps1									V
Ppat									V
Asrgl1										V
Adsl										V
Gls										V
Gfpt2										V
Aspa										V
Folh1										V
+ 00260: Glycine, serine and threonine metabolism	2.7	0.4	0.8	0.7	0.6	2.9	1.7	0.4	6.4	0.1
Bhmt	V								V
Gamt	V								V
Sds	V								V
Alas1	V		V	V		V			V	V
Maob	V					V
Sdsl		V			V
Gatm					V			V
Maoa					V					V
Glyctk					V				V
Chdh						V
Aldh7a1						V			V
Phgdh						V	V			V
Gcat						V			V
Alas2						V	V		V
Grhpr						V			V
Psat1							V			V
Srr									V
Agxt									V
Dmgdh									V
Cbs									V
Cth									V
Pipox									V
Sardh									V
Shmt2									V
Shmt1									V
Gldc									V
Gnmt									V
Agxt2									V
Psph										V
Aoc3										V
Aoc2										V
Dld										V
+ 00270: Cysteine and methionine metabolism	2.3	0.8	0.6	3.1	0.8	2.4	2.5	2.4	6.6	1.2
Kyat3	V					V			V	V
Kyat1	V							V	V
Bhmt	V								V
Ahcyl2	V	V		V		V				V
Sds	V								V
Sdsl		V			V
Bcat2			V			V			V	V
Tat				V					V
Srm				V
Dnmt3a				V	V			V	V	V
Cdo1				V		V	V			V
Got1					V				V
Ldha					V				V
Sms					V			V		V
Sms-ps					V			V		V
Tst						V			V
Mpst						V			V	V
Ldhb						V	V			V
Phgdh						V	V			V
Apip							V			V
Psat1							V			V
Ahcyl1								V		V
Adi1									V
Amd1									V
Cth									V
Cbs									V
Mat2b									V
Mat1a									V
Gm4737									V
Ahcy									V
Bhmt2									V
Got2									V
Agxt2									V
Gclc									V
Gclm									V
Gss									V
Mtap										V
Mtr										V
Mat2a										V
Enoph1										V
Mdh2										V
Bcat1										V
+ 00280: Valine, leucine and isoleucine degradation	6.5	0	1.3	1.8	0.7	6.5	1.9	0	4.6	2.6
Bckdhb	V								V	V
Acat1	V
Mccc1	V								V
Ivd	V					V				V
Acaa1a	V								V	V
Acaa1b	V			V					V
Hadh	V
Aox3	V					V			V
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Hsd17b10	V		V			V				V
Acadm	V									V
Acsf3	V					V				V
Bcat2			V			V			V	V
Hmgcs1				V	V				V
Acat2					V	V				V
Oxct1					V					V
Hadha					V				V	V
Acads					V					V
Bckdha						V				V
Hmgcs2						V			V
Mccc2						V				V
Echs1						V			V	V
Acadsb						V				V
Dbt						V	V
Pccb						V				V
Aldh7a1						V			V
Aldh6a1						V	V			V
Hibadh						V
Hibch						V	V			V
Acad8						V			V
Aacs						V				V
Mcee							V			V
Hmgcl									V
Acaa2									V
Abat									V
Agxt2									V
Dld										V
Auh										V
Bcat1										V
Hadhb										V
Pcca										V
+ 00290: Valine, leucine and isoleucine biosynthesis	1.6	1.6	1.9	0	1	1.2	0	0	1.8	0.9
Sds	V								V
Sdsl		V			V
Bcat2			V			V			V	V
Bcat1										V
+ 00310: Lysine degradation	4.8	0.3	1.2	0.5	1.5	2.1	1.8	1.2	4.7	1.8
Hadh	V
Dhtkd1	V		V			V	V			V
Acat1	V
Gcdh	V								V
Aldh9a1	V
Suv39h1	V									V
Kmt2e	V									V
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh1b1	V			V					V
Hykk	V								V
Nsd3		V						V	V	V
Ezh2			V							V
Hadha					V				V	V
Acat2					V	V				V
Dot1l					V			V		V
Kmt5a					V					V
Setd7					V					V
Colgalt1					V			V	V
Plod1					V					V
Plod2					V					V
Echs1						V			V	V
Aldh7a1						V			V
Camkmt						V				V
Ezh1						V				V
Phykpl						V
Smyd1							V
Ehmt1							V
Setd2							V			V
Aass									V
Aadat									V
Pipox									V
Bbox1									V
Ehmt2									V	V
Prdm2									V
Setd1b									V
Setdb1									V
Plod3									V	V
Kmt5c									V	V
Dld										V
Smyd2										V
Smyd3										V
Kmt2b										V
+ 00220: Arginine biosynthesis	2.3	0	0	2.1	1.1	0.9	0	0	5.3	0.3
Gls2	V			V					V
Glul	V					V				V
Asl	V								V
Ass1				V	V				V
Arg1					V				V
Got1					V				V
Gpt2						V			V
Cps1									V
Otc									V
Nags									V
Glud1									V
Got2									V
Gpt									V	V
Gls										V
Nos2										V
Nos3										V
+ 00330: Arginine and proline metabolism	5.1	0	0.6	2.6	2.6	1.6	0.9	1.3	3.6	1.7
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Maob	V					V
Gamt	V								V
Oat	V			V					V
Prodh	V					V	V			V
Aldh4a1	V			V						V
Prodh2	V		V						V
L3hypdh	V									V
Srm				V
Arg1					V				V
Gatm					V			V
Sms					V			V		V
Sms-ps					V			V		V
Sat1					V					V
Maoa					V					V
Cndp2					V					V
Pycr1					V					V
Aldh18a1					V					V
Got1					V				V
Aldh7a1						V			V
Ckmt1						V				V
Azin2						V	V			V
Amd1									V
Agmat									V
P4ha2									V	V
Got2									V
Hoga1									V
Lap3									V
Sat2										V
Ckb										V
Smox										V
Nos2										V
Nos3										V
Pycr2										V
P4ha1										V
+ 00340: Histidine metabolism	4	0	0	1.9	1.3	1.8	0	0	2.9	0.7
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Maob	V					V
Hnmt	V					V				V
Hal				V					V
Cndp2					V					V
Maoa					V					V
Aldh3b1					V
Aldh7a1						V			V
Ftcd									V
Amdhd1									V
Uroc1									V
Aldh1a3										V
Aldh3b2										V
Aspa										V
Hdc										V
+ 00350: Tyrosine metabolism	0.9	1.1	0	1.5	0.3	2.1	1.7	0	4.1	0
Maob	V					V
Aox3	V					V			V
Ddc		V							V
Comt		V				V			V
Hpd				V					V
Tat				V					V
Got1					V				V
Aldh3b1					V
Maoa					V					V
Fahd1						V			V
Fah						V	V		V
Adh1						V	V		V
Adh5							V		V
Hgd									V
Got2									V
Mif									V
Adh4									V
Gstz1										V
Aldh1a3										V
Aldh3b2										V
Aoc3										V
Aoc2										V
+ 00360: Phenylalanine metabolism	0.7	1.6	1.1	1.9	1.4	0.3	0	0	4	0.2
Maob	V					V
Ddc		V							V
Keg1		V	V						V
Hpd				V					V
Tat				V					V
Aldh3b1					V
Maoa					V					V
Got1					V				V
Gm4952					V				V
Got2									V
Mif									V
Glyat									V
Pah									V
Aldh1a3										V
Aldh3b2										V
Aoc3										V
Aoc2										V
+ 00380: Tryptophan metabolism	6.9	1.5	1.4	0.6	0.7	3.4	0.4	0.8	6.4	0.1
Hadh	V
Ido2	V								V
Maob	V					V
Acat1	V
Gcdh	V								V
Dhtkd1	V		V			V	V			V
Haao	V								V	V
Kyat3	V					V			V	V
Kyat1	V							V	V
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Aox3	V					V			V
Inmt	V					V			V
Cyp1a2		V							V
Ddc		V							V
Acmsd		V							V
Afmid			V		V			V	V
Maoa					V					V
Acat2					V	V				V
Hadha					V				V	V
Echs1						V			V	V
Tdo2						V			V
Aldh7a1						V			V
Cat									V
Aldh8a1									V
Kynu									V
Kmo									V
Aadat									V
Cyp1b1										V
Dld										V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	1.6	0.6	0	0	0	2.9	0
Tat				V					V
Got1					V				V
Pah									V
Got2									V
+ 1.6 Metabolism of other amino acids	5.5	2.1	0	3	1.3	5	2	1.1	6.6	2
+ 00410: beta-Alanine metabolism	3	0	0	0.8	1.3	2.4	2	0.5	3.9	1.4
Aldh2	V					V			V	V
Aldh3a2	V				V				V
Aldh9a1	V
Aldh1b1	V			V					V
Acox1	V							V	V	V
Acads					V					V
Hadha					V				V	V
Aldh3b1					V
Cndp2					V					V
Echs1						V			V	V
Hibch						V	V			V
Aldh6a1						V	V			V
Aldh7a1						V			V
Dpyd						V			V
Acox3							V		V
Abat									V
Upb1									V
Dpys									V
Aoc3										V
Aoc2										V
Aldh1a3										V
Aldh3b2										V
Smox										V
+ 00430: Taurine and hypotaurine metabolism	0	1.1	0	1.4	0.4	1.4	2.1	0	0.9	0.7
Csad		V				V	V		V	V
Cdo1				V		V	V			V
Ggt6					V
Baat									V
Ggt7										V
Ggt5										V
+ 00440: Phosphonate and phosphinate metabolism	2.5	0	0	1.7	0	2.8	0	0	1.5	0.5
Pcyt1a	V								V
Chpt1	V					V				V
Pcyt2				V		V			V
Cept1						V				V
+ 00450: Selenocompound metabolism	3.8	1.8	0	0	0.7	2.3	0	0.8	3.7	1.1
Kyat3	V					V			V	V
Kyat1	V							V	V
Pstk	V									V
Papss2	V				V					V
Inmt	V					V			V
Txnrd1		V							V
Papss1		V			V	V			V	V
Sephs2						V			V
Sepsecs									V	V
Cth									V
Mars1										V
Mtr										V
+ 00471: D-Glutamine and D-glutamate metabolism	2.8	0	0	1.8	0	0	0	0	1.8	0.3
Dglucy	V
Gls2	V			V					V
Glud1									V
Gls										V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0	0	0	0	0	0
+ 00480: Glutathione metabolism	2.4	2.7	0	2.2	1	4.3	1.2	1.5	5.7	1.2
Idh1	V								V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Gstk1	V					V
Chac1	V									V
Nat8		V							V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Gsta1				V					V
Gstm4				V					V	V
Pgd				V						V
Srm				V
Anpep					V			V	V
Ggt6					V
G6pdx					V					V
Hpgds					V			V		V
Sms					V			V		V
Sms-ps					V			V		V
Rrm1					V					V
Rrm2					V				V
Gpx3						V				V
Gpx8						V				V
Gpx4						V				V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Gss									V
Gclc									V
Gclm									V
Nat8f1									V
Nat8f2									V
Gstm6									V
Gsto1									V
Gstm7									V
Lap3									V
Chac2									V
Ggt7										V
Ggt5										V
Gpx7										V
Idh2										V
Oplah										V
Gstm2										V
Gsr										V
Rrm2b										V
+ 1.7 Glycan biosynthesis and metabolism	2.7	3	1.3	1.7	4.9	1.9	3	2.4	2.7	7.6
+ 00510: N-Glycan biosynthesis	0.3	1.5	1.4	2	1.3	0.5	2.1	0.3	1	3.3
Alg3	V	V							V	V
St6gal1		V			V				V
Alg8		V			V					V
Mgat1			V		V					V
Srd5a3			V	V						V
Alg2				V	V
Dpagt1				V		V			V
Mgat5					V
Man1c1					V			V		V
Dad1					V					V
B4galt1						V				V
Man2a2						V				V
Alg9							V			V
Fut8							V			V
Mgat4b							V			V
Dpm1							V			V
Dpm2									V	V
Man2a1									V
Ganab									V
Man1a									V
Alg14										V
Dpm3										V
Alg12										V
B4galt2										V
Mgat3										V
Man1b1										V
Alg11										V
Stt3b										V
Alg5										V
Alg1										V
Dolk										V
Ddost										V
Tusc3										V
+ 00513: Various types of N-glycan biosynthesis	0.9	0.4	0.8	0.7	0.9	0.3	1.7	0.4	0.2	2.9
Alg3	V	V							V	V
Hexb	V									V
Mgat1			V		V					V
Alg2				V	V
Man1c1					V			V		V
Dad1					V					V
Hexa					V					V
B4galt1						V				V
Man2a2						V				V
Alg9							V			V
Fut8							V			V
Mgat4b							V			V
Man1a									V
Man2a1									V
Alg11										V
Alg12										V
Alg1										V
Alg14										V
Ddost										V
Stt3b										V
Tusc3										V
B4galt2										V
St3gal3										V
Man1b1										V
+ 00512: Mucin type O-glycan biosynthesis	0	2.1	0	0.9	1.9	0.2	1.4	1.3	0.5	0.9
St3gal1		V							V
Galnt18		V								V
Gcnt4		V							V
Galnt11				V			V
Gcnt1					V					V
B4galt5					V				V
Galnt7					V			V
Galnt1					V		V			V
Galnt6					V			V
Galnt12					V					V
Galnt10						V				V
St3gal2										V
Galnt2										V
Galnt16										V
Galnt17										V
Galnt15										V
+ 00515: Mannose type O-glycan biosynthesis	0.6	0	0	0	0.1	0.8	0.7	0	0.1	1.8
Pomt1	V					V				V
Large1					V					V
B4galt1						V				V
Pomgnt1							V			V
B3galnt2									V
B4galt2										V
St3gal3										V
B3gat2										V
Pomk										V
B4gat1										V
Fkrp										V
Rxylt1										V
+ 00514: Other types of O-glycan biosynthesis	0.3	1.6	0	0.6	1.5	0.6	1	2.1	0.4	2.5
Pomt1	V					V				V
St6gal1		V			V				V
Gxylt1		V							V
Galnt18		V								V
Galnt11				V			V
Colgalt1					V			V	V
Pofut2					V			V		V
Galnt7					V			V
Galnt1					V		V			V
Galnt6					V			V
Galnt12					V					V
B4galt1						V				V
Galnt10						V				V
Plod3									V	V
B3glct										V
St3gal3										V
Lfng										V
Mfng										V
B4galt2										V
Xxylt1										V
Poglut1										V
Gxylt2										V
Eogt										V
Galnt2										V
Galnt16										V
Galnt17										V
Galnt15										V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.8	0	0	0	2.6	0.4	0	0.8	1.4	2.9
Csgalnact2	V									V
Xylt2					V					V
Xylt1					V			V		V
Csgalnact1					V					V
Chpf					V					V
Chst11					V					V
Chst15					V					V
Chpf2						V				V
B3gat3									V
B4galt7									V
Chsy3									V
Chst13									V
Chsy1										V
Chst7										V
Ust										V
Chst14										V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1.5	0	0	0	0.9	0	0.8	0.7	2.3	0.4
Extl2	V						V			V
Extl1	V								V
Xylt2					V					V
Xylt1					V			V		V
Ndst1					V				V
Hs3st3a1									V
Hs6st1									V
B4galt7									V
B3gat3									V
Ext2										V
Hs3st1										V
Hs2st1										V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	1	0	0	0	1.9	2	0	0.2	2.6
St3gal1		V							V
B4galt1						V				V
Chst1						V	V			V
Chst4						V				V
Fut8							V			V
B4galt2										V
St3gal3										V
B4galt4										V
B3gnt7										V
St3gal2										V
+ 00531: Glycosaminoglycan degradation	0.7	0	0	0	3	0.3	0.8	1.5	0.8	1.7
Hexb	V									V
Hpse					V
Galns					V			V		V
Idua					V		V			V
Glb1					V					V
Hyal1					V				V
Hexa					V					V
Gusb					V			V		V
Hgsnat						V			V	V
Gns									V
Ids										V
Arsb										V
Naglu										V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	0	0	1	0.4	0.3	0	0	0.3	2.6
Pigs				V	V					V
Pigt					V					V
Pigp						V				V
Dpm2									V	V
Gpld1									V
Pigq										V
Pigh										V
Pigc										V
Pigx										V
Pigm										V
Pigf										V
Pigl										V
Gpaa1										V
Pigz										V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0	0.7	0	0	0.3	1.2	0.7	0	0.2	1.4
St3gal4		V							V
B3gnt3					V					V
Gcnt2					V				V	V
St3gal6						V				V
B4galt1						V				V
B3galt2						V	V			V
B4galt4										V
B4galt2										V
Ggta1										V
St3gal3										V
A4galt										V
B3galnt1										V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0.8	0.9	1.3	1.2	0.7	0	0	0	0.2	0.9
Hexb	V									V
St3gal1		V							V
Naga			V	V	V					V
Hexa					V					V
St3gal2										V
A4galt										V
B3galnt1										V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0.9	1.9	1.3	0	1.9	0.5	0	0.9	2.3	1.4
Hexb	V									V
St3gal1		V							V
St3gal5		V							V
Slc33a1			V						V
Glb1					V					V
Hexa					V					V
B4galnt1					V			V	V
St6galnac4					V					V
St6galnac5						V				V
St6galnac6									V
St3gal2										V
B3galt4										V
+ 00511: Other glycan degradation	3.1	0.9	0	0	2.7	0.4	0	0.8	0.1	3.1
Man2c1	V	V				V			V	V
Fuca2	V				V					V
Aga	V									V
Hexb	V									V
Glb1					V					V
Man2b2					V
Hexa					V					V
Manba					V
Gba					V					V
Man2b1								V
Neu1										V
Neu3										V
Fuca1										V
Engase										V
Gba2										V
+ 1.8 Metabolism of cofactors and vitamins	5.8	2.6	2.2	2.5	1.7	4.1	3.6	1.3	11	2.1
+ 00730: Thiamine metabolism	0.9	0	0	0	0.3	0.5	1	0	0.7	0.6
Tpk1	V					V			V
Ak1					V		V			V
Ak2									V	V
Ak5										V
Ntpcr										V
Acp1										V
+ 00740: Riboflavin metabolism	1.2	0	0	0	1.3	0.8	1.3	2.3	3.4	1.8
Enpp3	V								V
Enpp1					V				V
Acp2					V			V	V	V
Acp5						V	V	V		V
Flad1									V	V
Blvrb									V
Rfk										V
Acp1										V
+ 00750: Vitamin B6 metabolism	1.2	0	0	0	1.2	2.4	2.3	0	1.1	0.2
Aox3	V					V			V
Phospho2					V	V
Pdxk					V
Pnpo						V	V		V
Psat1							V			V
Pdxp										V
+ 00760: Nicotinate and nicotinamide metabolism	5.4	1.6	2.2	1.4	0.5	2.8	0.4	0.4	3.1	1.2
Nudt12	V								V
Enpp3	V								V
Nmnat1	V	V
Nmnat3	V
Nadsyn1	V								V
Nnmt	V									V
Nadk2	V		V		V	V			V
Aox3	V					V			V
Sirt2	V				V					V
Sirt5	V					V				V
Sirt1	V		V	V
Pnp		V								V
Pnp2		V								V
Sirt3			V			V	V
Nnt				V
Enpp1					V				V
Nt5c2					V			V	V	V
Naprt						V			V	V
Nampt						V				V
Sirt4						V				V
Nt5e						V				V
Aspdh									V
Qprt									V
Nadk									V	V
Sirt7									V	V
Cd38										V
Nt5m										V
Nt5c										V
Nt5c3b										V
+ 00770: Pantothenate and CoA biosynthesis	3.8	0	1.2	0	0.2	2.9	0	0	3.7	0.1
Coasy	V					V			V	V
Enpp3	V								V
Pank1	V								V
Vnn1	V					V
Vnn3	V					V
Bcat2			V			V			V	V
Enpp1					V				V
Dpyd						V			V
Upb1									V
Dpys									V
Bcat1										V
+ 00780: Biotin metabolism	0	0	0	0	0	0	0	0	1	0
Btd									V
+ 00785: Lipoic acid metabolism	0	0	0	0	0	0	1.6	0	0.9	0.9
Lipt1							V
Acsm1									V
Lias										V
Lipt2										V
+ 00790: Folate biosynthesis	2	0	1	1.8	1.2	0.7	1.5	0	2.8	0.1
Dhfr	V								V
Qdpr	V			V					V
Pts	V					V				V
Mocs1			V
Mocs2				V	V	V	V			V
Mocos					V				V
Akr1b3					V					V
Akr1b8					V					V
Pcbd1							V		V
Gch1									V
Gphn									V
Pah									V
Spr									V
Ggh										V
+ 00670: One carbon pool by folate	0.8	0	0	1.1	1.1	0.4	0.9	0.8	3.9	0.1
Dhfr	V								V
Aldh1l1				V	V	V			V
Mthfd2					V			V		V
Mthfd1l					V
Gart							V
Ftcd									V
Mthfr									V
Mthfd1									V
Mthfsl									V
Mthfs									V
Shmt2									V
Shmt1									V
Mthfd2l										V
Atic										V
Mtr										V
+ 00830: Retinol metabolism	2.7	4.6	1.4	1.3	0	0.6	1.7	0.1	10.4	0
Aldh1a1	V					V			V	V
Aox3	V					V			V
Dgat1	V					V	V			V
Rdh16	V								V
Dhrs4	V						V		V
Cyp2a4	V								V
Cyp2c50	V			V					V
Cyp2c39	V								V
Cyp3a11		V		V					V
Cyp1a2		V							V
Dhrs9		V			V			V	V
Cyp4a12b		V							V
Cyp4a12a		V							V
Cyp2c40		V							V
Cyp2c70		V	V						V
Cyp2c68		V							V
Cyp2c55		V							V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Cyp2c54			V						V
Ugt2b34			V						V
Rdh11				V					V
Aldh1a2					V					V
Dhrs3					V					V
Adh1						V	V		V
Ugt1a7c						V				V
Ugt1a5						V			V
Adh5							V		V
Ugt1a1							V		V
Adh4									V
Bco1									V
Lrat									V
Retsat									V
Cyp26a1									V
Cyp3a13									V
Cyp3a25									V
Rdh7									V
Cyp2a12									V
Cyp2a5									V
Cyp4a32									V
Cyp4a10									V
Cyp4a14									V
Cyp4a31									V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp2c23									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Hsd17b6									V
Rdh5										V
Rdh12										V
Cyp2s1										V
Ugt1a6b										V
+ 00860: Porphyrin and chlorophyll metabolism	0.9	1.7	1.6	0.7	0.3	3.3	1.7	1	5.6	0.1
Cpox	V								V	V
Alas1	V		V	V		V			V	V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Ugt2b34			V						V
Gusb					V			V		V
Blvra					V					V
Hmox1					V			V		V
Ugt1a7c						V				V
Ugt1a5						V			V
Cp						V			V
Fxn						V
Heph						V				V
Hmbs						V				V
Alad						V	V		V
Alas2						V	V		V
Ugt1a1							V		V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Blvrb									V
Urod									V
Ugt1a6b										V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	1.1	1.1	0	2.5	0	0	0	0	1.6	2.2
Nqo1	V
Coq7		V								V
Hpd				V					V
Tat				V					V
Ggcx									V
Coq2										V
Coq3										V
Coq6										V
Coq5										V
Vkorc1										V
Vkorc1l1										V
+ 1.9 Metabolism of terpenoids and polyketides	0.6	1.5	0	3.5	1.8	1.3	0	0.7	3	0.3
+ 00900: Terpenoid backbone biosynthesis	0.6	1.5	0	3.5	1.8	1.3	0	0.7	3	0.3
Acat1	V
Idi1		V							V
Fdps		V		V					V
Hmgcs1				V	V				V
Hmgcr				V					V
Mvd				V	V			V	V
Acat2					V	V				V
Nus1					V
Pcyox1					V				V
Hmgcs2						V			V
Fnta						V				V
Rce1									V	V
Mvk										V
Pdss1										V
Fntb										V
+ 1.10 Biosynthesis of other secondary metabolites	2	1	0	1.2	0.6	0.7	0	2	2.2	0.6
+ 00232: Caffeine metabolism	1.4	1.4	0	0	0	1	0	1.4	2.3	0.1
Uox	V								V
Cyp1a2		V							V
Xdh						V		V		V
Nat2									V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	1.5	0	0	1.7	0.8	0	0	1.5	0.8	0.7
Gck	V			V					V
Hk3					V			V
Hk1										V
Hk2										V
+ 1.11 Xenobiotics biodegradation and metabolism	5.6	7.1	2.1	2.6	0.2	10.2	5.2	0.9	13.7	0.5
+ 00980: Metabolism of xenobiotics by cytochrome P450	2.4	4.5	0.5	1	0	5.9	3.2	0.2	7.8	0.2
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Gstk1	V					V
Dhdh	V					V
Hsd11b1	V					V			V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Ephx1		V			V				V
Cyp1a2		V							V
Ugt2b34			V						V
Gsta1				V					V
Gstm4				V					V	V
Hpgds					V			V		V
Aldh3b1					V
Cyp2e1						V	V			V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Ugt1a7c						V				V
Ugt1a5						V			V
Adh1						V	V		V
Cbr2						V				V
Cyp2f2						V			V
Ugt1a1							V		V
Adh5							V		V
Gstm6									V
Gsto1									V
Gstm7									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Adh4									V
Gstm2										V
Ugt1a6b										V
Aldh1a3										V
Aldh3b2										V
Cyp1b1										V
Cbr3										V
Cyp2s1										V
+ 00982: Drug metabolism - cytochrome P450	3.2	4	0.5	1.6	0	6.1	3.6	0.2	7.4	0.1
Fmo1	V			V		V	V			V
Fmo5	V					V			V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Gstk1	V					V
Maob	V					V
Aox3	V					V			V
Cyp1a2		V							V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Ugt2b34			V						V
Gsta1				V					V
Gstm4				V					V	V
Aldh3b1					V
Hpgds					V			V		V
Maoa					V					V
Fmo2						V				V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Adh1						V	V		V
Ugt1a7c						V				V
Ugt1a5						V			V
Cyp2e1						V	V			V
Adh5							V		V
Ugt1a1							V		V
Gstm6									V
Gsto1									V
Gstm7									V
Adh4									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Aldh1a3										V
Aldh3b2										V
Fmo3										V
Gstm2										V
Ugt1a6b										V
+ 00983: Drug metabolism - other enzymes	4	3.9	2.6	1.9	0.3	5.6	2.2	1.2	8.5	0.5
Upp2	V		V			V			V	V
Uck1	V					V				V
Tk1	V				V				V
Tk2	V			V	V	V		V
Ces1d	V		V			V	V			V
Ces1f	V					V			V	V
Cmpk1	V				V
Nme2	V									V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Ces2a		V							V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Nme6		V							V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Cda			V
Ces2c			V						V
Ugt2b34			V						V
Tymp				V
Gsta1				V					V
Gstm4				V					V	V
Upp1					V
Gusb					V			V		V
Rrm1					V					V
Rrm2					V				V
Xdh						V		V		V
Dpyd						V			V
Ugt1a7c						V				V
Ugt1a5						V			V
Nme3						V				V
Cyp2e1						V	V			V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Ugt1a1							V		V
Impdh2								V		V
Nat2									V
Dpys									V
Upb1									V
Umps									V
Ces1c									V
Ces1e									V
Ces2e									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Gstm6									V
Gsto1									V
Gstm7									V
Itpa										V
Uckl1										V
Impdh1										V
Ugt1a6b										V
Nme7										V
Rrm2b										V
Dut										V
Gstm2										V
+ 2. Genetic Information Processing	3.1	8.5	2.2	6.2	3.9	4.5	2.3	2.6	5.4	13.9
+ 2.1 Transcription	0	4.7	1.6	1.4	0.3	0.5	0.5	0.3	1.2	6.7
+ 03020: RNA polymerase	0	2.1	1	0	0.3	0	0	0	0.9	2.2
Polr1d		V	V							V
Polr1b		V							V
Znrd1		V								V
Polr2a					V					V
Polr3g					V				V
Polr2b									V
Polr2h									V
Polr2c										V
Polr2d										V
Polr2e										V
Polr2f										V
Polr2g										V
Polr2l										V
Polr3k										V
Polr3h										V
Polr3gl										V
Polr1a										V
Polr3e										V
+ 03022: Basal transcription factors	0	2.2	0.7	0.6	0.2	0.1	0	0.3	0.6	1.6
Gtf2b		V
Gtf2ird1		V							V
Gtf2f1		V
Ercc2		V
Gtf2a2			V						V	V
Mnat1				V						V
Taf1					V
Taf6l					V					V
Ccnh					V					V
Gtf2i						V				V
Taf9b								V		V
Tbpl1									V	V
Taf8									V
Gtf2e1									V
Taf3										V
Taf5l										V
Taf10										V
Taf11										V
Gtf2f2										V
Gtf2h1										V
Gtf2h3										V
Gtf2h4										V
Ercc3										V
Gtf2h5										V
Cdk7										V
+ 03040: Spliceosome	0	3.8	1.1	1.8	0	0.8	0.8	0.1	0.6	7.9
Snrpa		V								V
Sf3a1		V
Sf3a3		V								V
Sf3b1		V			V				V	V
U2af1		V				V				V
Puf60		V								V
Hnrnpc		V							V
Hnrnpm		V	V						V	V
Srsf5		V	V							V
Plrg1		V
Prpf6		V
Acin1		V				V			V	V
Rbm25			V							V
Snrnp70				V						V
Prpf40b				V		V				V
Srsf2				V
Srsf7				V						V
Prpf19				V
Tcerg1					V
Hnrnpk					V			V		V
Hspa8					V			V	V	V
Wbp11					V
Ppih					V	V				V
Rbmx						V			V	V
Hnrnpu						V			V	V
Srsf1						V			V	V
Isy1						V				V
Eftud2						V				V
Snrpb							V			V
U2af1l4							V
Pqbp1							V
Ppie							V			V
Ddx46									V
Sf3b3									V	V
Lsm6									V
Prpf8									V	V
Txnl4a									V	V
Thoc2									V
Ddx39b										V
Snrpc										V
Prpf40a										V
Dhx15										V
Snrpd2										V
Snrpe										V
Snrpg										V
Snrpf										V
Snrpa1										V
Snrpb2										V
Sf3b4										V
Sf3b6										V
Sf3b5										V
Ddx42										V
U2af2										V
Smndc1										V
Cherp										V
Ncbp2										V
Hnrnpa1										V
Rbmxl1										V
Srsf9										V
Srsf3										V
Tra2b										V
Srsf6										V
Bcas2										V
Cwc15										V
Ctnnbl1										V
Hspa2										V
Hspa1a										V
Xab2										V
Syf2										V
Snw1										V
Ccdc12										V
Rbm22										V
Aqr										V
Lsm4										V
Lsm7										V
Lsm5										V
Lsm3										V
Lsm8										V
Prpf31										V
Prpf3										V
LOC100862468										V
Snu13										V
Snrnp40										V
Ddx23										V
Snrnp27										V
Sart1										V
Eif4a3										V
Rbm8a										V
Magoh										V
Magohb										V
Alyref										V
Thoc1										V
Thoc3										V
Zmat2										V
Prpf38a										V
Bud31										V
+ 2.2 Translation	1.2	5.8	0.7	2	0.7	4.2	1.2	1.4	2.8	11
+ 03010: Ribosome	0.3	3.3	0.2	1.3	0	4.5	2.2	0.9	0.1	11.4
Rps25	V									V
Rplp0	V									V
Mrpl1	V								V
Rps19		V			V	V			V	V
Rps24		V		V		V			V	V
Rps28		V							V	V
Rpl12		V								V
Rpl5		V	V	V	V					V
Rpl35		V								V
Rpl7		V								V
Rpl36a		V
Rpl36al		V
Rpl37rt		V								V
Rpl37		V								V
Mrpl28				V		V				V
Rpsa				V					V	V
Rpl22					V					V
Rpl10					V		V	V	V	V
Fau						V	V			V
Rps18						V
Rps17						V			V	V
Rps27l						V
Rps10						V	V			V
Rpl11						V				V
Rpl13a						V				V
Mrpl2						V				V
LOC100044627						V				V
LOC100862455						V				V
Rpl23						V				V
Rpl18						V		V		V
LOC108167922						V	V			V
Rpl27						V	V			V
Rplp2						V				V
Mrpl20						V				V
Mrpl36						V				V
Rps2						V				V
Mrps12						V				V
Mrps15						V				V
Mrps21						V	V			V
Mrpl3							V
Rpl37a							V			V
Rpl3								V		V
Rpl29								V		V
Gm8210								V		V
Mrpl10									V	V
Mrpl15									V
Rpl15									V	V
Rpl13										V
Rpl28										V
Rps14										V
Rps23										V
Rps29										V
Rps13										V
Rps11										V
Rps15										V
Rps6-ps4										V
Rps6										V
Rps8										V
Rps27rt										V
Rps27										V
Rps27a										V
Rps7										V
Rps12										V
Rps21										V
Rps4x										V
Rps3a1										V
Mrpl11										V
Rpl9										V
Mrpl13										V
Rpl8										V
Rpl27a										V
Mrpl18										V
Rpl17										V
Rpl23a										V
Mrpl23										V
Rpl26										V
Mrpl24										V
Mrpl30										V
Rpl19										V
Rpl21										V
Rpl24										V
Rpl30										V
Rpl39										V
Rpl41										V
Rpl31										V
Rpl32										V
Gm4705										V
Rpl34-ps1										V
Rpl34										V
Rpl6										V
Rpl18a										V
Rpl22l1										V
Rpl36										V
Rpl38										V
Rpl4										V
Rpl7a										V
Rpl14										V
Mrpl4										V
Rplp1										V
Mrpl17										V
Mrpl27										V
Mrpl33										V
Mrps9										V
Rps5										V
Rps15a										V
Rps16										V
Rps20										V
Rps3										V
Mrps14										V
Mrps17										V
Mrps6										V
Mrps16										V
Rps9										V
+ 00970: Aminoacyl-tRNA biosynthesis	1.4	4.3	0.7	1.4	0	0.6	0	0.9	3.4	1.3
Farsb	V	V		V					V
Tars2	V								V	V
Pstk	V									V
Iars		V						V	V
Rars2		V
Sars		V							V
Aars		V		V					V
Kars		V
Wars		V								V
Yars		V								V
Farsa			V			V				V
Hars2						V			V	V
Cars2						V			V	V
Gatb								V	V	V
Fars2									V	V
Cars									V	V
Vars2									V
Tars									V
Sepsecs									V	V
Iars2										V
Gars										V
Mars1										V
Vars										V
Lars2										V
Lars										V
+ 03013: RNA transport	0.3	0.8	0	1	0.4	1.8	0.5	0.4	1	5.2
Nxt2	V				V				V
Rangap1	V								V	V
Pop4	V									V
Rpp21	V				V					V
Casc3		V							V	V
Acin1		V				V			V	V
Sumo3		V							V	V
Eif2b4		V							V
Cyfip1		V			V					V
Aaas				V	V					V
Eif1a				V				V		V
Eif4a2				V		V	V			V
Eif4e2				V		V
Tpr					V				V
Senp2					V				V	V
Nup210					V				V
Nup214					V					V
Thoc6					V					V
Eif4a1					V					V
Eif4g1					V				V
Upf3b					V	V			V	V
Nup35					V	V				V
Cyfip2					V			V		V
Fmr1					V		V			V
Phax						V				V
Rnps1						V				V
Rpp25						V				V
Rpp25l						V				V
Pop7						V				V
Elac2						V				V
Thoc7						V				V
Eif2s3y						V			V	V
Eif4ebp3						V
Eif4ebp1						V	V			V
Eif2b3						V	V			V
Ube2i								V		V
Eef1a1								V	V
Gemin2									V	V
Pnn									V	V
Nup155									V
Nup88									V
Upf1									V
Thoc2									V
Pabpc1									V	V
Eif5b									V	V
Ran										V
Ncbp2										V
Smn1										V
Gemin7										V
Gemin8										V
Rbm8a										V
Magoh										V
Magohb										V
Eif4a3										V
Sap18b										V
Sap18										V
Nxf1										V
Alyref										V
Nup205										V
Nup188										V
Nup62										V
Nup93										V
Nup37										V
Sec13										V
Nup107										V
Nup85										V
Nup133										V
Sumo2										V
Sumo1										V
Eef1a2										V
Ddx39b										V
Pym1										V
Eif1										V
Eif1ax										V
Eif1b										V
Eif3e										V
Eif3g										V
Eif3i										V
Eif3d										V
Eif3f										V
Eif3h										V
Rpp38										V
Rpp30										V
Rpp14										V
Elac1										V
Thoc1										V
Thoc3										V
Pabpc1l										V
Eif4e										V
Upf3a										V
Tacc3										V
Eif2b1										V
Eif2b2										V
Fxr1										V
Fxr2										V
+ 03015: mRNA surveillance pathway	0.3	0.8	0.3	0	0.6	1.8	0	0.1	0.6	4.2
Nxt2	V				V				V
Ppp2r1b	V					V				V
Casc3		V							V	V
Acin1		V				V			V	V
Papola		V							V	V
Cpsf4			V
Upf3b					V	V			V	V
Rnmt					V
Cpsf7					V					V
Cstf2					V	V				V
Ppp2r5b					V					V
Ppp2r5c					V			V		V
Ppp1cc					V					V
Ppp1ccb					V					V
Rnps1						V				V
Pcf11						V				V
Clp1						V
Cstf3						V				V
Pabpn1						V				V
Ppp2r3a						V
Pnn									V	V
Upf1									V
Smg7									V
Pabpc1									V	V
Wdr33									V
Rbm8a										V
Magoh										V
Magohb										V
Eif4a3										V
Sap18b										V
Sap18										V
Nxf1										V
Alyref										V
Upf3a										V
Ddx39b										V
Pym1										V
Smg5										V
Gspt2										V
Cpsf6										V
Fip1l1										V
Cstf1										V
Ncbp2										V
Pabpc1l										V
Ppp2ca										V
Ppp2cb										V
Ppp2r5a										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r3c										V
Ppp2r2a										V
Ppp2r2b										V
Dazap1										V
Ppp1ca										V
Ssu72										V
+ 03008: Ribosome biogenesis in eukaryotes	0.4	3.7	0.4	0.9	0.4	0.5	0	0.8	1.1	2.4
Pop4	V									V
Nxt2	V				V				V
Nop58		V	V
Nop56		V							V
Utp14a		V
Gnl2		V							V
Gnl3		V			V				V	V
Heatr1		V							V
Wdr43		V
Lsg1		V						V	V	V
Spata5		V
Dkc1				V		V
Csnk2b				V				V	V
Mphosph10					V					V
Csnk2a1					V				V
Csnk2a2					V
Ak6					V			V		V
Rbm28					V					V
Rpp25						V				V
Rpp25l						V				V
Pop7						V				V
Imp3						V				V
Rcl1									V
Mdn1									V
Riok1									V
Ran										V
LOC100862468										V
Snu13										V
Fbl										V
Nop10										V
Nhp2										V
Fcf1										V
Drosha										V
Nat10										V
Rpp38										V
Rpp30										V
Gnl3l										V
Nvl										V
Rexo5										V
Rexo1										V
Nxf1										V
Wdr75										V
Utp4										V
Nol6										V
Rrp7a										V
Riok2										V
Eif6										V
Sbds										V
Nob1										V
+ 2.3 Folding, sorting and degradation	2.3	5.6	2	6.3	2.1	2.6	1.7	2	6.2	6.2
+ 03060: Protein export	2.5	5	0	3.9	0.6	0.6	0	0	1.7	0.4
Immp2l	V					V				V
Gm4184	V	V		V					V
Gm11575	V	V		V					V
Sec61g	V	V		V					V
Srp19		V			V
Spcs2		V			V
Sec11a		V
Srprb		V
Hspa5		V		V					V
Sec61a1				V
Sec11c					V
Oxa1l						V				V
Srp54c									V	V
Spcs3									V
Srp14										V
Sec61a2										V
Arxes1										V
Arxes2										V
Immp1l										V
+ 04141: Protein processing in endoplasmic reticulum	1.9	6	1.3	5.7	2.8	0.7	0.5	1.3	7.6	1.8
Mapk8	V
Gm4184	V	V		V					V
Gm11575	V	V		V					V
Sec61g	V	V		V					V
Rad23a	V									V
Ube4b	V									V
Herpud1	V			V					V
Nfe2l2	V
Hsph1	V	V		V	V				V	V
Calr		V		V	V				V
Pdia3		V							V
Sec24c		V
Uggt1		V			V				V	V
Syvn1		V							V
Hspa5		V		V					V
Xbp1		V				V
Derl3		V							V
Selenos		V		V
Pdia4		V		V					V
Dnajc3		V							V
Dnajb11		V			V	V			V	V
Hsp90aa1		V					V		V
Preb		V							V
Hsp90b1		V							V
Hyou1		V		V	V				V
Ssr2		V								V
Sec24a			V						V
Lman1			V		V				V	V
Dnaja1			V			V			V	V
Sec31a			V						V	V
Ddit3				V	V					V
Sec61a1				V
Eif2ak3				V
Dnajb2				V					V
Dnajb1				V
Pdia6				V				V	V
Dad1					V					V
Edem1					V				V
Sec23a					V				V
Sec23b					V
Ufd1					V	V				V
Man1c1					V			V		V
Ube2g1					V			V	V
Bax					V			V		V
Ern1					V				V
Wfs1					V			V		V
Rad23b					V				V
Plaa					V
Hspa8					V			V	V	V
Sel1l					V				V
Rbx1					V			V		V
Ube2d3					V				V
Dnajc1					V
Hspa4l					V
Cryab					V					V
Ckap4					V					V
Sec24b						V				V
Derl1						V				V
Fbxo2						V				V
Stub1						V			V	V
Ubxn6						V
Skp1a						V	V		V	V
Ssr4						V			V
Capn1							V
Ssr3							V		V	V
Map2k7									V	V
Canx									V
Edem2									V
Edem3									V
Ero1lb									V
Man1a									V
Ganab									V
Atf6									V
Yod1									V
Atxn3									V
Derl2									V
Txndc5									V
P4hb									V	V
Hsp90ab1									V	V
Sar1b									V
Tram1									V
Hspbp1									V
Rrbp1									V	V
Atf4										V
Mapk9										V
Traf2										V
Casp12										V
Capn2										V
Sec61a2										V
Ddost										V
Stt3b										V
Tusc3										V
Man1b1										V
Bak1										V
Ubqln2										V
Ngly1										V
Ube2j2										V
Ube2j1										V
Hspa2										V
Hspa1a										V
Erlec1										V
Fbxo6										V
Ube2d1										V
Ube2d2a										V
Erp29										V
Dnajc10										V
Nsfl1c										V
Svip										V
Cul1										V
Sec13										V
Bcl2										V
Prkn										V
Bcap31										V
+ 04130: SNARE interactions in vesicular transport	0	0.6	0	0.8	0	0.5	0.6	0.5	0.7	1.5
Stx18		V							V	V
Vamp8				V
Stx2					V			V		V
Vamp1						V				V
Vamp2						V				V
Use1							V		V	V
Bet1									V
Vamp7									V
Ykt6										V
Stx6										V
Vti1a										V
Stx8										V
Vamp4										V
Vamp5										V
Stx1a										V
Vamp3										V
+ 04120: Ubiquitin mediated proteolysis	0.8	0.4	1	1.8	0.9	0.7	0.4	1.3	1	4.9
Rhobtb1	V			V						V
Mdm2	V	V			V					V
Smurf1	V									V
Ube4b	V									V
Birc6	V			V	V					V
Elob		V								V
Syvn1		V							V
Itch			V		V				V
Uba7			V							V
Nedd4			V
Cul2				V
Prpf19				V
Herc1				V		V	V			V
Rbx1					V			V		V
Vhl					V					V
Cdc20					V
Brca1					V
Cbl					V
Ube2d3					V				V
Wwp1					V				V
Ube2c					V			V		V
Ube2a					V
Ube2g1					V			V	V
Herc2					V
Wwp2					V			V
Fbxo2						V				V
Herc4						V			V
Skp1a						V	V		V	V
Cul7						V				V
Ube2k						V				V
Stub1						V			V	V
Ube2o						V				V
Anapc13						V				V
Ube2r2							V			V
Ube2n								V		V
Ube2i								V		V
Mgrn1									V
Pias2									V	V
Xiap									V
Pml									V
Cblc									V
Smurf2									V
Ube4a									V
Ube2m									V	V
Ube2b									V
Uba2										V
Sae1										V
Eloc										V
Fbxo4										V
Btrc										V
Klhl13										V
Ddb2										V
Ube2w										V
Uba3										V
Cdc23										V
Cdc16										V
Anapc5										V
Anapc4										V
Cdc27										V
Anapc1										V
Anapc2										V
Anapc11										V
Fbxw8										V
Cul1										V
Rnf7										V
Ddb1										V
Cul4a										V
Trim37										V
Trim32										V
Nhlrc1										V
Pias3										V
Pias1										V
Pias4										V
Birc3										V
Siah1a										V
Prkn										V
Cblb										V
Ube2d1										V
Ube2d2a										V
Ube2j1										V
Ube3b										V
Ube2s										V
Ube2j2										V
Ppil2										V
Trip12										V
Ube2q2										V
Ube2q1										V
Ube2h										V
Ube2e2										V
Ube2e3										V
Ube2e1										V
+ 04122: Sulfur relay system	0	0	0	1.5	0.6	2.5	1.3	0	1.2	1.8
Mocs2				V	V	V	V			V
Tst						V			V
Mpst						V			V	V
Urm1										V
Ctu2										V
Ctu1										V
+ 03050: Proteasome	0.8	1.6	1.5	2.7	0.4	1.8	1.6	0.9	1.5	3.9
Psmc1	V
Psmb8	V									V
Psmd12		V							V	V
Psmd11		V				V			V
Psma3		V								V
Psma4			V						V
Psmb1			V				V
Psmd1				V						V
Psmc4				V					V	V
Psme2				V		V				V
Psme2b				V		V				V
Psmd13					V	V		V		V
Psmd14					V					V
Psme4					V				V
Psma6					V	V				V
Psma7						V				V
Psmd2							V	V
Psmf1							V			V
Psmd8									V	V
Adrm1									V	V
Psmc3									V	V
Psmd6										V
Sem1										V
Psmd4										V
Psmc5										V
Psme1										V
Psma2										V
Psma5										V
Psma1										V
Psmb3										V
Psmb2										V
Psmb5										V
Psmb10										V
+ 03018: RNA degradation	0.1	1.4	1.6	0.3	0.1	0.1	0	1.2	2.7	2.2
Pnldc1	V
Exosc1		V
Ttc37		V			V				V	V
Btg3		V								V
Pan2		V							V
Exosc5			V			V				V
Cnot1			V		V				V
Nudt16			V							V
Btg2				V						V
Cnot6					V			V	V
Cnot9					V
Hspd1					V			V	V
Eno3						V				V
Tob2						V				V
Edc3								V		V
Patl1								V
Skiv2l									V	V
Exosc10									V	V
Tent4a									V
Tent4b									V
Cnot3									V
Cnot7									V	V
Cnot8									V
Dcps									V	V
Lsm6									V
Tob1									V
Pabpc1									V	V
Pan3									V	V
Eno2										V
Pnpt1										V
Wdr61										V
Exosc9										V
Exosc8										V
Mphosph6										V
Cnot10										V
Dcp1b										V
Lsm3										V
Lsm4										V
Lsm5										V
Lsm7										V
Lsm8										V
Edc4										V
Parn										V
Btg1										V
Pabpc1l										V
Pfkl										V
Pfkm										V
Pfkp										V
+ 2.4 Replication and repair	2.6	0.9	0	2.6	4.7	1.6	1.2	1.5	0.6	3.9
+ 03030: DNA replication	1.7	0	0	1.6	3.7	0.1	0.6	1.8	0.1	1.6
Pold4	V									V
Mcm6	V			V	V			V		V
Rpa1	V			V
Fen1					V
Dna2					V
Rnaseh2b					V
Pcna					V			V		V
Mcm5					V			V		V
Mcm2					V
Mcm3					V					V
Prim2					V					V
Pole					V
Pole2					V
Pole4						V				V
Pola2							V			V
Ssbp1									V
Rfc1									V
Rpa3										V
Pole3										V
Mcm4										V
Pold2										V
Mcm7										V
Rpa2										V
+ 03410: Base excision repair	0.5	1.9	0	0	1.6	1.4	0.6	0.5	0.7	2.5
Pold4	V									V
Apex1		V								V
Lig3		V							V
Ung		V							V
Fen1					V
Pole					V
Pole2					V
Pcna					V			V		V
Neil3					V
Tdg					V				V	V
Pole4						V				V
Neil2						V				V
Mpg						V				V
Neil1						V
Ogg1							V			V
Parp3									V	V
Parp2										V
Parp4										V
Pole3										V
Pold2										V
Mutyh										V
Xrcc1										V
Gm21596										V
Hmgb1										V
+ 03420: Nucleotide excision repair	1.5	0.4	0	1.4	1.2	0.1	0	0.9	0.1	3.8
Pold4	V									V
Rpa1	V			V
Rad23a	V									V
Ercc2		V
Mnat1				V						V
Ccnh					V					V
Rbx1					V			V		V
Pcna					V			V		V
Pole					V
Pole2					V
Rad23b					V				V
Pole4						V				V
Rfc1									V
Gtf2h4										V
Gtf2h3										V
Gtf2h1										V
Gtf2h5										V
Ercc3										V
Cdk7										V
Ddb1										V
Cul4a										V
Pole3										V
Ercc5										V
Pold2										V
Rpa2										V
Rpa3										V
Ercc1										V
Xpa										V
Ddb2										V
Cetn2										V
Xpc										V
+ 03430: Mismatch repair	1.5	0	0	2	0.1	0.3	0	0.7	0.4	0.4
Pold4	V									V
Rpa1	V			V
Mlh1				V		V
Pcna					V			V		V
Rfc1									V
Ssbp1									V
Msh2										V
Pold2										V
Rpa2										V
Rpa3										V
+ 03440: Homologous recombination	0.9	0	0	0.7	2.4	0.7	1.7	0	0.2	0.7
Rpa1	V			V
Pold4	V									V
Blm					V				V
Rad50					V					V
Xrcc2					V
Rad51					V
Rad54l					V
Sycp3					V	V				V
Brca1					V
Rbbp8					V
Topbp1					V					V
Top3b						V			V	V
Rad52						V	V
Rad51d							V			V
Babam2							V			V
Ssbp1									V
Sem1										V
Xrcc3										V
Mus81										V
Rpa2										V
Rpa3										V
Pold2										V
+ 03450: Non-homologous end-joining	0	0	0	0	1.5	1.3	0	0	0	0.2
Dclre1c					V					V
Rad50					V					V
Fen1					V
Xrcc5						V
Xrcc6						V
Prkdc										V
+ 03460: Fanconi anemia pathway	0.7	0	0	1.3	1.9	0.5	0.3	0	0.1	1.1
Rpa1	V			V
Rev3l	V
Mlh1				V		V
Fancc					V	V				V
Blm					V				V
Brca1					V
Ube2t					V
Cenpx					V					V
Polh					V
Rad51					V
Faap24					V					V
Poln					V					V
Top3b						V			V	V
Rev1							V			V
Wdr48									V	V
Fancg										V
Faap100										V
Rmi1										V
Atrip										V
Rpa2										V
Rpa3										V
Telo2										V
Fan1										V
Mus81										V
Eme2										V
Ercc1										V
+ 3. Environmental Information Processing	7.4	2.9	3.7	3	10.9	4.1	4.2	6.9	3.3	15.6
+ 3.1 Membrane transport	4.4	0.4	0.7	0.6	0.7	0.2	0.4	0.3	3.2	0.5
+ 02010: ABC transporters	4.4	0.4	0.7	0.6	0.7	0.2	0.4	0.3	3.2	0.5
Abcg8	V								V
Abcg5	V								V
Abcd2	V					V				V
Abcd1	V				V					V
Abcc3	V				V				V
Abcb1a	V					V				V
Tap2	V	V								V
Tap1	V									V
Defb1	V
Abca3			V
Abcd3				V				V	V
Abcg3					V
Abcg1					V					V
Abcb4					V				V
Abca8b							V		V
Abcb11									V
Abcc6									V
Abcc2									V
Abcb7									V
Abcb6									V
Abca9									V
Abca6									V
Abcg4										V
Abcc4										V
Abcc5										V
Abcc1										V
Abcb1b										V
Abcb9										V
Abcb8										V
Abca8a										V
+ 3.2 Signal transduction	7.8	3.7	4.7	4.6	11.9	6.7	5.9	7.9	2.5	22.5
+ 04010: MAPK signaling pathway	1.6	0.2	2.2	1.2	3.7	0.4	0.5	1.7	0.2	7.4
Dusp6	V			V
Ikbkg	V				V				V	V
Mapk3	V					V				V
Rasgrp2	V		V			V				V
Grb2	V	V			V					V
Map2k6	V		V		V
Map3k20	V									V
Fas	V				V					V
Mapk8	V
Arrb1	V				V					V
Jun	V									V
Rps6ka1	V			V	V
Fgf21	V			V	V
Rela		V						V	V
Egfr		V							V
Hspb1		V
Igf1		V	V						V
Kit			V
Met			V			V			V
Mapk14			V	V	V				V
Map2k3			V
Map3k13			V						V
Fgf1			V						V
Ddit3				V	V					V
Flt3l				V						V
Irak1				V				V		V
Dusp10					V					V
Dusp9					V					V
Ptpn7					V					V
Dusp3					V					V
Map4k4					V					V
Stmn1					V					V
Nfkb2					V					V
Relb					V	V	V	V		V
Mapk1					V			V		V
Rasa1					V			V
Rap1b					V					V
Gna12					V
Csf1r					V
Ntrk2					V		V	V		V
Cacna1a					V
Cacna1d					V					V
Cacng5					V
Mapkapk3					V					V
Mapk12					V					V
Akt1					V					V
Taok2					V					V
Stk4					V
Gadd45a					V					V
Gadd45b					V			V		V
Daxx					V					V
Tgfb1					V					V
Tnf					V
Rac2					V					V
Arrb2					V				V	V
Hspa8					V			V	V	V
Fos					V					V
Nfatc1					V					V
Map3k8					V					V
Rps6ka2					V					V
Mknk1					V	V		V		V
Angpt2					V					V
Csf1					V					V
Pdgfa					V					V
Pdgfc					V					V
Raf1						V		V		V
Braf						V
Rras						V				V
Map4k2						V				V
Ecsit						V				V
Gadd45g						V				V
Mapkapk5						V	V			V
Mapk8ip1						V				V
Srf						V				V
Angpt1						V				V
Fgf10						V				V
Vegfb						V	V			V
Ppp3ca							V			V
Igf2							V			V
Ngf							V
Rap1a								V		V
Cd14								V		V
Map3k11								V
Ppm1b									V	V
Kras									V
Rasgrp3									V
Sos1									V
Epha2									V
Erbb3									V
Fgfr3									V
Fgfr4									V
Flt4									V
Taok3									V
Il1rap									V
Il1a									V
Il1b									V
Map2k7									V	V
Mapk8ip3									V	V
Klk1b4									V
Tgfa									V
Irak4									V
Dusp8										V
Dusp1										V
Dusp7										V
Dusp5										V
Dusp4										V
Dusp16										V
Pla2g4a										V
Nfkb1										V
Chuk										V
Ikbkb										V
Map3k14										V
Lamtor3										V
Map2k1										V
Nf1										V
Prkcb										V
Prkaca										V
Rasa2										V
Mras										V
Rras2										V
Rasgrp4										V
Gng12										V
Erbb2										V
Fgfr1										V
Igf1r										V
Tek										V
Cacna1c										V
Cacna2d1										V
Cacnb1										V
Cacnb3										V
Cacng7										V
Nr4a1										V
Mapk7										V
Map2k5										V
Cdc25b										V
Rps6ka4										V
Rps6ka5										V
Mapkapk2										V
Atf4										V
Max										V
Elk4										V
Elk1										V
Mapk11										V
Ppm1a										V
Akt2										V
Akt3										V
Map3k6										V
Stk3										V
Tab2										V
Tab1										V
Traf2										V
Tgfbr2										V
Il1r1										V
Tnfrsf1a										V
Tgfb2										V
Tgfb3										V
Cdc42										V
Rac3										V
Rac1										V
Pak2										V
Map3k3										V
Mapk9										V
Map2k4										V
Hspa2										V
Hspa1a										V
Jund										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Flnc										V
Map4k1										V
Map4k3										V
Myc										V
Rps6ka3										V
Mknk2										V
Angpt4										V
Efna2										V
Efna4										V
Efna5										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Vegfd										V
Ntf3										V
Pgf										V
Vegfc										V
Pdgfd										V
Araf										V
+ 04012: ErbB signaling pathway	2.5	0.5	0	0.8	1.1	1.8	2.8	2.2	0.2	4.2
Grb2	V	V			V					V
Gsk3b	V									V
Mapk8	V
Jun	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Egfr		V							V
Cdkn1a				V	V			V		V
Stat5b					V
Cbl					V
Shc2					V					V
Plcg2					V			V		V
Hbegf					V
Pik3cd					V
Akt1					V					V
Mapk1					V			V		V
Eif4ebp1						V	V			V
Cdkn1b						V	V			V
Ptk2						V	V			V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Stat5a							V			V
Mtor							V			V
Btc							V			V
Src							V	V
Abl1								V		V
Erbb3									V
Rps6kb1									V
Tgfa									V
Map2k7									V	V
Sos1									V
Kras									V
Elk1										V
Erbb2										V
Rps6kb2										V
Pak2										V
Nck1										V
Nck2										V
Bad										V
Map2k4										V
Cblb										V
Mapk9										V
Prkcb										V
Camk2d										V
Camk2a										V
Camk2g										V
Plcg1										V
Pik3r3										V
Akt2										V
Akt3										V
Nrg4										V
Myc										V
Map2k1										V
Araf										V
+ 04014: Ras signaling pathway	1.6	0.2	1.6	0.6	2	0.8	0.9	1.2	0.1	4.8
Mapk3	V					V				V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Fgf21	V			V	V
Ikbkg	V				V				V	V
Mapk8	V
Pla2g6	V			V	V	V	V			V
Rasgrp2	V		V			V				V
Exoc2	V
Shoc2	V									V
Igf1		V	V						V
Egfr		V							V
Rela		V						V	V
Fgf1			V						V
Kit			V
Met			V			V			V
Gnb2			V							V
Flt3l				V						V
Mapk1					V			V		V
Akt1					V					V
Pik3cd					V
Shc2					V					V
Angpt2					V					V
Csf1					V					V
Pdgfa					V					V
Pdgfc					V					V
Csf1r					V
Ntrk2					V		V	V		V
Gab2					V					V
Rac2					V					V
Rgl2					V					V
Pla2g2e					V					V
Rab5c					V					V
Rasa1					V			V
Rasa4					V					V
Rassf5					V				V
Stk4					V
Rap1b					V					V
Arf6					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gng2					V					V
Plcg2					V			V		V
Rel					V
Raf1						V		V		V
Rras						V				V
Pik3r2						V				V
Angpt1						V				V
Fgf10						V				V
Vegfb						V	V			V
Pla2g2d						V				V
Pla2g12a						V				V
Gnb1						V				V
Gnb5						V				V
Igf2							V			V
Ngf							V
Plce1							V			V
Plaat3							V			V
Abl1								V		V
Bcl2l1								V
Rap1a								V		V
Kras									V
Sos1									V
Klk1b4									V
Tgfa									V
Epha2									V
Fgfr3									V
Fgfr4									V
Flt4									V
Pla2g12b									V
Rasgrp3									V
Afdn									V
Tbk1									V
Brap									V
Map2k1										V
Mras										V
Rras2										V
Akt2										V
Akt3										V
Pik3r3										V
Angpt4										V
Efna2										V
Efna4										V
Efna5										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Vegfd										V
Ntf3										V
Pgf										V
Vegfc										V
Pdgfd										V
Fgfr1										V
Igf1r										V
Tek										V
Ptpn11										V
Tiam1										V
Rac3										V
Rac1										V
Ralgds										V
Rgl1										V
Rala										V
Ralb										V
Pld2										V
Prkcb										V
Rin1										V
Bad										V
Chuk										V
Ikbkb										V
Nfkb1										V
Mapk9										V
Ralbp1										V
Cdc42										V
Pla2g4a										V
Elk1										V
Rasgrp4										V
Rasa2										V
Rasa3										V
Nf1										V
Rhoa										V
Rassf1										V
Calml4										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Plcg1										V
Lat										V
Pak2										V
Ksr1										V
Prkaca										V
+ 04015: Rap1 signaling pathway	1.6	0.7	2.5	0.4	4.5	1.7	1	2	1.5	4.4
Mapk3	V					V				V
Fgf21	V			V	V
Map2k6	V		V		V
P2ry1	V				V
Rapgef1	V	V							V
Ctnnb1	V				V					V
Rasgrp2	V		V			V				V
Adcy6	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Igf1		V	V						V
Egfr		V							V
Cdh1		V							V
Rapgef4		V							V	V
Prkd3		V							V
Fgf1			V						V
Kit			V
Met			V			V			V
Map2k3			V
Mapk14			V	V	V				V
Mapk1					V			V		V
Rap1b					V					V
Apbb1ip					V			V		V
Angpt2					V					V
Csf1					V					V
Pdgfa					V					V
Pdgfc					V					V
Csf1r					V
Rac2					V					V
Rassf5					V				V
Mapk12					V					V
Evl					V			V		V
Pfn1					V					V
Actb					V					V
Sipa1l1					V			V
Sipa1					V					V
Itgam					V					V
Itgb1					V					V
Itgb2					V			V
F2r					V				V
Lpar5					V
Lpar3					V					V
Magi1					V				V
Vav1					V			V
Vav3					V					V
Adcy3					V					V
Adcy7					V
Gnao1					V					V
Pik3cd					V
Akt1					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Tln1					V					V
Lcp2					V			V
Fyb					V				V
Thbs1					V					V
Raf1						V		V		V
Angpt1						V				V
Fgf10						V				V
Vegfb						V	V			V
Rapgef3						V		V		V
Braf						V
Gnas						V				V
Prkd1						V				V
Gnai1						V	V			V
Pik3r2						V				V
Rras						V				V
Pard6b						V
Pard6g						V	V			V
Ngf							V
Prkd2							V			V
Src							V	V
Plce1							V			V
Rap1a								V		V
Klk1b4									V
Epha2									V
Fgfr3									V
Fgfr4									V
Flt4									V
Afdn									V
Itgb2l									V
Fpr1									V
Gnaq									V
Magi3									V
Pard3									V
Farp2									V
Rasgrp3									V
Adcy9									V
Kras									V
Prkcz									V	V
Map2k1										V
Angpt4										V
Efna2										V
Efna4										V
Efna5										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Vegfd										V
Pgf										V
Vegfc										V
Pdgfd										V
Fgfr1										V
Igf1r										V
Tek										V
Ralgds										V
Rac3										V
Rac1										V
Mapk11										V
Vasp										V
Pfn2										V
Actg1										V
Rala										V
Ralb										V
Adora2a										V
Adora2b										V
Lpar1										V
Lpar4										V
Tiam1										V
Rhoa										V
Krit1										V
Cdc42										V
Mras										V
Adcy4										V
Adcy5										V
Cnr1										V
Gnai2										V
Pik3r3										V
Akt2										V
Akt3										V
Sipa1l3										V
Calml4										V
Prkcb										V
Lat										V
Plcg1										V
Prkci										V
Pard6a										V
+ 04310: Wnt signaling pathway	1.6	0	0.1	0.3	1.3	0	0.5	0.2	0.1	3.1
Fzd4	V		V							V
Fzd8	V
Mapk8	V
Jun	V									V
Tbl1x	V
Tbl1xr1	V			V
Ctnnb1	V				V					V
Gsk3b	V									V
Ccnd1		V			V				V
Csnk2b				V				V	V
Nfatc1					V					V
Wnt5a					V					V
Rac2					V					V
Dvl1					V					V
Wnt11					V					V
Fosl1					V			V
Smad4					V					V
Rbx1					V			V		V
Nkd1					V					V
Senp2					V				V	V
Csnk2a1					V				V
Csnk2a2					V
Wif1					V
Sfrp4					V					V
Sfrp5					V		V			V
Wnt8b					V
Serpinf1					V				V
Skp1a						V	V		V	V
Porcn						V				V
Wnt2b						V				V
Rspo1						V				V
Ppp3ca							V			V
Prickle1							V			V
Wnt5b									V	V
Chd8									V
Wnt2									V
Notum									V
Rnf43									V
Lgr5									V
Nfatc4										V
Prkcb										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Camk2d										V
Camk2a										V
Camk2g										V
Fzd1										V
Fzd6										V
Fzd2										V
Mapk9										V
Rac3										V
Rac1										V
Rhoa										V
Daam1										V
Dvl2										V
Prickle4										V
Prickle3										V
Vangl1										V
Ppard										V
Ccnd2										V
Ccnd3										V
Myc										V
Ctbp1										V
Ctbp2										V
Sox17										V
Tcf7l1										V
Tcf7l2										V
Ctnnbip1										V
Cul1										V
Btrc										V
Siah1a										V
Nkd2										V
Axin2										V
Prkaca										V
Csnk1e										V
Sfrp2										V
Sfrp1										V
Wnt9a										V
Wnt6										V
Bambi										V
Ryk										V
Cby1										V
+ 04330: Notch signaling pathway	0.7	0.3	0.6	0	1.4	0	2	1.8	0.2	3.3
Aph1a	V					V				V
Adam17	V
Atxn1l		V							V
Numb			V
Aph1b					V					V
Aph1c					V					V
Psen2					V				V	V
Ncor2					V			V		V
Dtx4					V			V
Notch2					V			V	V
Notch4					V		V			V
Dvl1					V					V
Dtx2							V			V
Dll1							V
Heyl							V			V
Numbl								V		V
Dtx3l									V
Ncstn										V
Hdac1										V
Cir1										V
Ctbp1										V
Ctbp2										V
Snw1										V
Psenen										V
Dtx3										V
Jag1										V
Jag2										V
Notch1										V
Notch3										V
Dvl2										V
Lfng										V
Mfng										V
Dll4										V
Hey1										V
Hey2										V
+ 04340: Hedgehog signaling pathway	1.9	0.4	0.7	0.6	1	0.2	0.4	0.3	0.5	5
Gsk3b	V									V
Smurf1	V									V
Grk2	V				V					V
Arrb1	V				V					V
Ccnd1		V			V				V
Spop			V							V
Csnk1g3				V	V
Arrb2					V				V	V
Kif3a					V					V
Smo						V				V
Gas1						V				V
Cdon							V	V		V
Ptch1									V
Smurf2									V
Mgrn1									V
Csnk1g2										V
Csnk1d										V
Csnk1e										V
Prkaca										V
Gli1										V
Gli2										V
Gli3										V
Kif7										V
Cul1										V
Btrc										V
Ptch2										V
Sufu										V
Boc										V
Lrp2										V
Evc										V
Evc2										V
Grk3										V
Ccnd2										V
Bcl2										V
Megf8										V
Mosmo										V
+ 04350: TGF-beta signaling pathway	2.6	1.6	2.5	0	1	2.7	0.8	0.6	1.4	4.1
Acvr1	V									V
Ppp2r1b	V					V				V
Zfyve16	V									V
Zfyve9	V		V
Mapk3	V					V				V
Smurf1	V									V
Dcn	V					V				V
Hamp2	V								V
Id3		V				V				V
Inhba		V
Bmp6		V					V			V
Smad9		V				V			V
Hamp		V	V						V
Smad5			V			V				V
Chrd			V
Hjv			V						V
Thbs1					V					V
Rbx1					V			V		V
Smad4					V					V
Smad2					V					V
Tfdp1					V					V
Mapk1					V			V		V
Tgfb1					V					V
Tnf					V
Gdf6					V
Smad1					V				V
Tgif1					V			V	V
Acvr1c						V				V
Skp1a						V	V		V	V
Bmp4						V				V
Nbl1						V				V
Fmod						V				V
Rgma						V				V
Grem2						V				V
Smad6							V			V
E2f4									V
Id2									V
Inhbc									V
Inhbe									V
Rps6kb1									V
Smurf2									V
Bmp2									V
Ltbp1										V
Cul1										V
Cdkn2b										V
Myc										V
Rbl1										V
Inhbb										V
Fst										V
Lefty1										V
Rps6kb2										V
Ppp2ca										V
Ppp2cb										V
Ppp2r1a										V
Rock1										V
Rhoa										V
Tgfbr2										V
Tgfb2										V
Tgfb3										V
Amhr2										V
Bmpr2										V
Bmpr1a										V
Bmp7										V
Gdf5										V
Nog										V
Bambi										V
+ 04390: Hippo signaling pathway	2	1.3	0.9	0.4	2.5	0.3	0.9	0.5	0.6	5.2
Frmd6	V									V
Wwtr1	V				V					V
Dlg1	V						V
Fzd4	V		V							V
Fzd8	V
Gsk3b	V									V
Ctnnb1	V				V					V
Ppp2r1b	V					V				V
Rassf6	V			V					V
Nf2		V			V		V	V	V
Ctnna1		V			V		V	V		V
Cdh1		V							V
Ajuba		V								V
Ccnd1		V			V				V
Bmp6		V					V			V
Dlg3			V
Fgf1			V						V
Ywhae				V						V
Lats2					V					V
Ccn2					V					V
Birc5					V
Ppp1cc					V					V
Ppp1ccb					V					V
Ywhaq					V					V
Actb					V					V
Smad2					V					V
Itgb2					V			V
Tgfb1					V					V
Smad4					V					V
Serpine1					V			V		V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Dvl1					V					V
Nkd1					V					V
Gdf6					V
Smad1					V				V
Crb2						V				V
Trp53bp2						V
Ywhag						V			V	V
Pard6b						V
Pard6g						V	V			V
Wnt2b						V				V
Bmp4						V				V
Wwc1									V
Patj									V	V
Llgl1									V	V
Pard3									V
Prkcz									V	V
Itgb2l									V
Wnt2									V
Wnt5b									V	V
Bmp2									V
Id2									V
Sav1										V
Stk3										V
Rassf1										V
Ppp1ca										V
Ywhah										V
Ywhaz										V
Ywhab										V
Scrib										V
Tead1										V
Tead2										V
Wtip										V
Actg1										V
Pard6a										V
Prkci										V
Csnk1d										V
Csnk1e										V
Btrc										V
Tgfb2										V
Tgfb3										V
Tgfbr2										V
Wnt9a										V
Wnt6										V
Fzd1										V
Fzd6										V
Fzd2										V
Dvl2										V
Axin2										V
Tcf7l1										V
Tcf7l2										V
Myc										V
Ccnd2										V
Ccnd3										V
Bmp7										V
Gdf5										V
Bmpr1a										V
Bmpr2										V
Ppp2ca										V
Ppp2cb										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r2a										V
Ppp2r2b										V
Gli2										V
+ 04392: Hippo signaling pathway - multiple species	2	1.5	0	0.9	1.7	0	0.7	2.1	0.6	1.9
Frmd6	V									V
Wwtr1	V				V					V
Rassf6	V			V					V
Nf2		V			V		V	V	V
Ajuba		V								V
Lats2					V					V
Rassf4					V			V		V
Rassf2					V			V
Wwc1									V
Sav1										V
Stk3										V
Tead1										V
Tead2										V
Csnk1e										V
Rassf1										V
Wtip										V
+ 04370: VEGF signaling pathway	1.1	0.3	0.6	1.2	1.7	1.4	1.3	1.7	0.1	4.6
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Hspb1		V
Mapk14			V	V	V				V
Plcg2					V			V		V
Mapkapk3					V					V
Akt1					V					V
Pik3cd					V
Mapk12					V					V
Shc2					V					V
Mapk1					V			V		V
Rac2					V					V
Pik3r2						V				V
Ptk2						V	V			V
Raf1						V		V		V
Ppp3ca							V			V
Src							V	V
Sphk2									V	V
Kras									V
Cdc42										V
Plcg1										V
Sphk1										V
Pla2g4a										V
Mapkapk2										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Akt2										V
Akt3										V
Pik3r3										V
Prkcb										V
Mapk11										V
Map2k1										V
Nos3										V
Casp9										V
Bad										V
Rac3										V
Rac1										V
+ 04371: Apelin signaling pathway	0.5	0.4	0.5	0.4	2.2	1.9	2.6	1.3	0.1	5.9
Prkag2	V					V				V
Mapk3	V					V				V
Adcy6	V					V				V
Egr1	V			V	V					V
Nrf1		V								V
Ccnd1		V			V				V
Cdh1		V							V
Gnb2			V							V
Pik3c3			V			V				V
Itpr1				V						V
Prkab1					V	V			V	V
Serpine1					V			V		V
Gng2					V					V
Pik3cg					V					V
Pik3r5					V			V		V
Akt1					V					V
Mapk1					V			V		V
Ccn2					V					V
Adcy3					V					V
Adcy7					V
Mef2d					V			V
Gna13					V					V
Becn1					V					V
Spp1					V				V
Smad4					V					V
Smad2					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Rras						V				V
Raf1						V		V		V
Klf2						V				V
Pde3b						V	V			V
Lipe						V	V			V
Plin1						V				V
Prkab2							V			V
Prkag3							V
Mtor							V			V
Myl2							V
Apln							V			V
Agtr1a							V
Pik3r4								V		V
Prkaa2									V
Sphk2									V	V
Rps6kb1									V
Kras									V
Ppargc1a									V
Adcy9									V
Gnaq									V
Aplnr										V
Prkaa1										V
Prkag1										V
Sphk1										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Akt2										V
Akt3										V
Map2k1										V
Rps6kb2										V
Itpr3										V
Mras										V
Rras2										V
Mylk										V
Prkce										V
Adcy4										V
Adcy5										V
Prkaca										V
Nos2										V
Nos3										V
Mef2a										V
Hdac5										V
Gabarap										V
Gabarapl2										V
Notch3										V
Jag1										V
Plat										V
Acta2										V
Rps6-ps4										V
Rps6										V
Calml4										V
+ 04064: NF-kappa B signaling pathway	0.2	0.3	0.3	1.6	4.1	0	0.6	5.3	0.4	3.8
Ikbkg	V				V				V	V
Blnk	V				V			V		V
Rela		V						V	V
Icam1		V			V
Cxcl12			V		V				V	V
Nfkbia				V				V		V
Irak1				V				V		V
Lbp				V	V					V
Csnk2b				V				V	V
Ripk1					V
Tnf					V
Nfkb2					V					V
Relb					V	V	V	V		V
Tnfrsf11a					V			V		V
Ticam2					V					V
Ly96					V
Csnk2a1					V				V
Csnk2a2					V
Plau					V					V
Bcl2a1d					V					V
Plcg2					V			V		V
Syk					V			V		V
Lyn					V
Btk					V			V		V
Cflar					V				V	V
Gadd45b					V			V		V
Ccl4					V			V
Vcam1					V					V
Cxcl2					V
Tab3							V
Ltb							V
Bcl2l1								V
Tnfaip3								V
Cd14								V		V
Ube2i								V		V
Irak4									V
Il1b									V
Card10									V	V
Tirap									V
Xiap									V
Bcl2										V
Birc3										V
Traf2										V
Il1r1										V
Tnfrsf1a										V
Map3k14										V
Chuk										V
Ikbkb										V
Nfkb1										V
Cd40										V
Plcg1										V
Prkcb										V
Bcl10										V
Traf1										V
Tlr4										V
Tab1										V
Tab2										V
Lat										V
Bcl2a1b										V
Pias4										V
LOC100041504										V
LOC100041593										V
Ccl21b										V
Gm10591										V
Gm13304										V
Ccl21d										V
Ccl21c										V
Gm1987										V
Ccl21a										V
Gm2023										V
Ccl19										V
+ 04668: TNF signaling pathway	2.2	0.6	1.7	1.5	4.6	0.5	0.1	1.6	0.2	4.5
Map2k6	V		V		V
Mapk8	V
Ikbkg	V				V				V	V
Mapk3	V					V				V
Jun	V									V
Fas	V				V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Rela		V						V	V
Bcl3		V			V				V
Icam1		V			V
Map2k3			V
Mapk14			V	V	V				V
Itch			V		V				V
Nfkbia				V				V		V
Creb3l2				V
Tnf					V
Ripk1					V
Mapk12					V					V
Map3k8					V					V
Mapk1					V			V		V
Creb3					V					V
Fos					V					V
Casp8					V					V
Ccl2					V			V		V
Cxcl2					V
Cxcl10					V	V		V		V
Csf1					V					V
Junb					V
Mmp3					V					V
Vcam1					V					V
Tnfrsf1b					V
Pik3cd					V
Akt1					V					V
Ripk3					V					V
Dnm1l					V					V
Cflar					V				V	V
Mmp9						V				V
Pik3r2						V				V
Bag4						V
Tab3							V
Tnfaip3								V
Map2k7									V	V
Creb3l3									V
Cebpb									V
Il1b									V
Tnfrsf1a										V
Traf2										V
Birc3										V
Map2k4										V
Mapk11										V
Mapk9										V
Ikbkb										V
Nfkb1										V
Map2k1										V
Rps6ka4										V
Rps6ka5										V
Atf4										V
Creb3l1										V
Fadd										V
Casp7										V
Ccl12										V
Ccl5										V
Cx3cl1										V
Il18r1										V
Jag1										V
Traf1										V
Mmp14										V
Edn1										V
Vegfd										V
Vegfc										V
Pik3r3										V
Akt2										V
Akt3										V
Map3k14										V
Chuk										V
Mlkl										V
Tab1										V
Tab2										V
+ 04066: HIF-1 signaling pathway	0.4	1.7	0.7	1.5	2.7	3	1.3	3.8	0.8	5.2
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Elob		V								V
Igf1		V	V						V
Egfr		V							V
Pfkfb3		V			V		V			V
Rela		V						V	V
Stat3		V			V			V
Arnt			V
Cul2				V
Eif4e2				V		V
Cdkn1a				V	V			V		V
Rbx1					V			V		V
Vhl					V					V
Hif1a					V			V	V
Pik3cd					V
Akt1					V					V
Cybb					V			V		V
Plcg2					V			V		V
Ldha					V				V
Hk3					V			V
Gapdh-ps15					V				V
Gapdh					V				V
Serpine1					V			V		V
Angpt2					V					V
Timp1					V
Hmox1					V			V		V
Mapk1					V			V		V
Mknk1					V	V		V		V
Egln2						V				V
Pik3r2						V				V
Ldhb						V	V			V
Pdk1						V				V
Pdha1						V				V
Pdhb						V				V
Eno3						V				V
Angpt1						V				V
Ifngr1						V				V
Eif4ebp1						V	V			V
Cdkn1b						V	V			V
Mtor							V			V
Egln3									V
Aldoc									V
Aldob									V
Pgk1									V
Tfrc									V
Il6ra									V
Rps6kb1									V
Eloc										V
Egln1										V
Slc2a1										V
Erbb2										V
Igf1r										V
Pik3r3										V
Akt2										V
Akt3										V
Plcg1										V
Prkcb										V
Camk2d										V
Camk2a										V
Camk2g										V
Hk1										V
Hk2										V
Pfkl										V
Pfkm										V
Pfkp										V
Eno2										V
Angpt4										V
Tek										V
Edn1										V
Nos2										V
Nos3										V
Tlr4										V
Nfkb1										V
Ifngr2										V
Eif4e										V
Rps6kb2										V
Rps6-ps4										V
Rps6										V
Map2k1										V
Mknk2										V
Bcl2										V
+ 04068: FoxO signaling pathway	2.3	2.3	1.5	1.3	4	3.1	1.5	2.1	1.1	5.1
Mapk8	V
Mapk3	V					V				V
Prkag2	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Grb2	V	V			V					V
Mdm2	V	V			V					V
Sirt1	V		V	V
Slc2a4	V					V	V			V
Irs1		V				V
Egfr		V							V
Igf1		V	V						V
Ccnd1		V			V				V
Agap2		V								V
Stat3		V			V			V
Pten			V			V				V
Mapk14			V	V	V				V
Cdkn1a				V	V			V		V
Mapk1					V			V		V
Prkab1					V	V			V	V
Akt1					V					V
Pik3cd					V
Stk4					V
Ccnb2					V
Ccnb1					V
Cdkn2d					V					V
Plk1					V
Plk2					V					V
Gadd45a					V					V
Gadd45b					V			V		V
Sod2					V				V
Il7r					V			V		V
Homer3					V			V		V
Atg12					V					V
Smad4					V					V
Il10					V
Mapk12					V					V
Setd7					V					V
Ccng2					V	V				V
Tgfb1					V					V
Braf						V
Raf1						V		V		V
Pck1						V	V
Pik3r2						V				V
Cdkn1b						V	V			V
Gadd45g						V				V
Klf2						V				V
Bnip3						V	V			V
Stk11						V				V
Prkab2							V			V
Prkag3							V
Sgk1								V		V
Prkaa2									V
Sos1									V
Kras									V
G6pc									V
Plk3									V
Bcl6									V	V
Cat									V
Homer2									V
Sgk2									V
Prmt1									V	V
Usp7									V
Chuk										V
Ikbkb										V
Mapk9										V
Prkaa1										V
Prkag1										V
Foxo6										V
Foxo1										V
Map2k1										V
Araf										V
Pck2										V
G6pc3										V
Akt2										V
Akt3										V
Pik3r3										V
Irs3										V
Irs2										V
Igf1r										V
Ccnd2										V
Cdkn2b										V
Tnfsf10										V
S1pr1										V
S1pr4										V
Csnk1e										V
Gabarap										V
Gabarapl2										V
Sgk3										V
Tgfbr2										V
Mapk11										V
Fbxo25										V
Fbxo32										V
Tgfb2										V
Tgfb3										V
+ 04020: Calcium signaling pathway	0.1	0.2	1.1	0.2	2.8	0.4	1.2	0.2	0	2.2
Vdac1	V									V
Gna14	V
Stim2	V				V
Egfr		V							V
Avpr1a		V	V			V			V
Atp2a2		V			V				V
Phkg2			V	V	V	V				V
Atp2b4			V							V
Stim1			V			V			V	V
Itpr1				V						V
Itpkb					V					V
Adcy3					V					V
Pde1b					V					V
Tpcn2					V					V
Tpcn1					V
Gna15					V					V
P2rx4					V			V		V
P2rx7					V			V
Plcg2					V			V		V
Cacna1d					V					V
Cacna1a					V
Cxcr4					V			V		V
F2r					V				V
Htr2b					V
Oxtr					V
Ptafr					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Tnnc1					V
Adcy7					V
Atp2a3					V		V			V
Gnal					V
Atp2b1					V					V
Casq1					V
Trdn					V
Asph					V	V	V			V
Itpka						V				V
Plcd1						V				V
Phkg1						V				V
Slc25a4						V				V
Slc25a5						V			V	V
Adrb3						V				V
Gnas						V				V
Ppp3ca							V			V
Plce1							V			V
Phkb							V
Agtr1a							V
Casq2							V			V
Ppif									V
Erbb3									V
Gnaq									V
Sphk2									V	V
Adra1b									V
Adcy9									V
Atp2b2									V
Nos2										V
Nos3										V
Vdac2										V
Vdac3										V
Camk2d										V
Camk2a										V
Camk2g										V
Camk1										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Prkcb										V
Ptk2b										V
Cd38										V
Erbb2										V
Gna11										V
Grin2d										V
P2rx6										V
P2rx5										V
Plcg1										V
Sphk1										V
Mylk										V
Plcd3										V
Itpr3										V
Phka2										V
Orai1										V
Orai2										V
Cacna1c										V
Adra1d										V
Ednra										V
Ednrb										V
Cysltr1										V
Calml4										V
Adcy4										V
Adora2a										V
Adora2b										V
Adrb1										V
Adrb2										V
Prkaca										V
+ 04070: Phosphatidylinositol signaling system	0.9	1.2	0.8	1.8	3.3	1.1	1.6	2.3	0.9	3.1
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ipmk	V								V
Ip6k2	V					V			V
Pi4kb		V								V
Pik3c2a		V					V		V
Mtmr4		V			V		V		V
Ppip5k2		V			V				V	V
Pten			V			V				V
Pik3c3			V			V				V
Itpr1				V						V
Pi4k2a				V	V			V	V
Pip4p1				V						V
Plcg2					V			V		V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Cdipt					V					V
Pik3cd					V
Pip5k1c					V				V
Pi4k2b					V			V	V
Dgkz					V			V		V
Inpp4b					V
Ocrl					V
Pip4k2b					V
Pip4k2a					V			V		V
Itpk1					V			V
Itpkb					V					V
Inpp5d					V			V		V
Mtmr6					V					V
Plcd1						V				V
Pik3r2						V				V
Itpka						V				V
Plce1							V			V
Synj1							V
Mtmr14							V			V
Inpp5k									V	V
Inppl1									V	V
Mtmr1									V
Ip6k1									V	V
Plcg1										V
Plcd3										V
Calml4										V
Itpr3										V
Pik3r3										V
Pip5k1b										V
Pi4ka										V
Dgka										V
Inpp5e										V
Pip4k2c										V
Mtm1										V
Inpp1										V
Inpp5j										V
Inpp5a										V
Mtmr2										V
Pip4p2										V
Ppip5k1										V
Prkcb										V
+ 04072: Phospholipase D signaling pathway	1	0.6	0.5	0.1	2.8	1.9	0.6	2.2	0	3.7
Mapk3	V					V				V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Adcy6	V					V				V
Agpat2	V					V				V
Egfr		V							V
Avpr1a		V	V			V			V
Rapgef4		V							V	V
Kit			V
Mapk1					V			V		V
Akt1					V					V
Pik3cd					V
Shc2					V					V
Gab2					V					V
F2r					V				V
Lpar5					V
Lpar3					V					V
Plcg2					V			V		V
Pip5k1c					V				V
Gna13					V					V
Pik3cg					V					V
Pik3r5					V			V		V
Cyth4					V			V
Adcy3					V					V
Adcy7					V
Gna12					V
Dgkz					V			V		V
Pdgfa					V					V
Pdgfc					V					V
Dnm1					V					V
Fcer1g					V			V		V
Syk					V			V		V
Arf6					V
Raf1						V		V		V
Rras						V				V
Pik3r2						V				V
Rapgef3						V		V		V
Gnas						V				V
Fyn						V				V
Agpat3						V
Agpat1						V				V
Agt						V	V
Agtr1a							V
Mtor							V			V
Cyth1							V
Kras									V
Sos1									V
Adcy9									V
Sphk2									V	V
F2									V
Map2k1										V
Mras										V
Rras2										V
Akt2										V
Akt3										V
Pik3r3										V
Ptpn11										V
Ralgds										V
Rala										V
Ralb										V
Rhoa										V
Lpar1										V
Lpar6										V
Lpar4										V
Plcg1										V
Pld2										V
Tsc2										V
Rheb										V
Pip5k1b										V
Cyth2										V
Cyth3										V
Adcy4										V
Adcy5										V
Ptk2b										V
Pla2g4a										V
Plpp1										V
Plpp3										V
Dgka										V
Sphk1										V
Pdgfd										V
Dnm2										V
Fcer1a										V
Agpat5										V
Agpat4										V
+ 04071: Sphingolipid signaling pathway	3.2	0.5	1.1	0.5	2.5	1.1	0.1	2.2	0.2	5.6
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Cers2	V								V	V
Smpd2	V									V
Asah2	V
Ppp2r1b	V					V				V
Mapk8	V
Bid	V
Sgms2	V
Kng1	V								V
Ctsd		V			V			V		V
Rela		V						V	V
Adora1		V
S1pr5			V						V
Pten			V			V				V
Mapk14			V	V	V				V
Mapk1					V			V		V
Akt1					V					V
Pik3cd					V
S1pr2					V					V
Gna12					V
Gna13					V					V
Tnf					V
Sptlc3					V
Asah1					V					V
Ppp2r5b					V					V
Ppp2r5c					V			V		V
Mapk12					V					V
Bax					V			V		V
Sgpl1					V			V
Sgms1					V					V
Rac2					V					V
Fcer1g					V			V		V
Gab2					V					V
Raf1						V		V		V
Pik3r2						V				V
Gnai1						V	V			V
Ppp2r3a						V
Fyn						V				V
Gnaq									V
Kras									V
Sphk2									V	V
Prkcz									V	V
Kng2									V
Map2k1										V
Akt2										V
Akt3										V
Pik3r3										V
Prkcb										V
S1pr1										V
S1pr3										V
S1pr4										V
Gnai2										V
Rhoa										V
Rock1										V
Sptlc2										V
Sptlc1										V
Cers4										V
Cers5										V
Nsmaf										V
Sphk1										V
Abcc1										V
Ppp2ca										V
Ppp2cb										V
Ppp2r5a										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r3c										V
Ppp2r2a										V
Ppp2r2b										V
Smpd1										V
Mapk9										V
Mapk11										V
Bcl2										V
Nos3										V
Nfkb1										V
Rac3										V
Rac1										V
Tnfrsf1a										V
Fcer1a										V
Pld2										V
Traf2										V
Prkce										V
+ 04024: cAMP signaling pathway	1	0.2	0.2	0.7	1.4	1	1.3	1.1	0	4.2
Sucnr1	V
Adcy6	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Mapk8	V
Jun	V									V
Acox1	V							V	V	V
Atp2a2		V			V				V
Adora1		V
Rapgef4		V							V	V
Rela		V						V	V
Atp2b4			V							V
Ppp1r1b			V
Atp1b1				V
Creb3l2				V
Nfkbia				V				V		V
Cacna1d					V					V
Atp2a3					V		V			V
Atp1a1					V				V
Oxtr					V
Ffar2					V					V
Adcy3					V					V
Adcy7					V
Pik3cd					V
Akt1					V					V
Mapk1					V			V		V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Atp2b1					V					V
Rap1b					V					V
Creb3					V					V
Vipr2					V
Nfatc1					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Fos					V					V
F2r					V				V
Vav1					V			V
Vav3					V					V
Rac2					V					V
Atp1a2						V				V
Hcar1						V	V			V
Gnai1						V	V			V
Gnas						V				V
Pik3r2						V				V
Rapgef3						V		V		V
Raf1						V		V		V
Braf						V
Pde3b						V	V			V
Rras						V				V
Lipe						V	V			V
Fxyd1						V			V	V
Fxyd2							V			V
Plce1							V			V
Acox3							V		V
Rap1a								V		V
Sstr2									V
Gabbr2									V
Adcy9									V
Atp2b2									V
Creb3l3									V
Afdn									V
Ppara									V
Ptch1									V
Cacna1c										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Adrb2										V
Ednra										V
Npy1r										V
Gabbr1										V
Hcar2										V
Gnai2										V
Adcy4										V
Adcy5										V
Prkaca										V
Pik3r3										V
Akt2										V
Akt3										V
Calml4										V
Map2k1										V
Mapk9										V
Creb3l1										V
Rhoa										V
Rock1										V
Ppp1r12a										V
Camk2d										V
Camk2a										V
Camk2g										V
Adora2a										V
Adrb1										V
Mc2r										V
Ptger2										V
Tshr										V
Gipr										V
Pde3a										V
Bad										V
Gli3										V
Nfkb1										V
Abcc4										V
Rras2										V
Pld2										V
Gria1										V
Gria3										V
Grin2d										V
Orai1										V
Hcn2										V
Hcn4										V
Ppp1ca										V
Gli1										V
Myl9										V
Tiam1										V
Rac3										V
Rac1										V
Edn1										V
Sst										V
+ 04022: cGMP-PKG signaling pathway	0.3	0.4	0.1	0.6	1.6	1.3	1.8	0.3	0.1	4.3
Mapk3	V					V				V
Adcy6	V					V				V
Vdac1	V									V
Kng1	V								V
Atp2a2		V			V				V
Gtf2ird1		V							V
Irs1		V				V
Adora1		V
Atp2b4			V							V
Itpr1				V						V
Creb3l2				V
Atp1b1				V
Ppp1cc					V					V
Ppp1ccb					V					V
Cacna1d					V					V
Nfatc1					V					V
Mef2d					V			V
Atp2a3					V		V			V
Mapk1					V			V		V
Creb3					V					V
Atp1a1					V				V
Atp2b1					V					V
Pik3cg					V					V
Pik3r5					V			V		V
Akt1					V					V
Adcy3					V					V
Adcy7					V
Pde2a					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gna12					V
Gna13					V					V
Gucy1a1						V				V
Npr2						V				V
Srf						V				V
Raf1						V		V		V
Atp1a2						V				V
Gtf2i						V				V
Pde3b						V	V			V
Slc25a4						V				V
Slc25a5						V			V	V
Adrb3						V				V
Gnai1						V	V			V
Agtr1a							V
Ppp3ca							V			V
Kcnj8							V			V
Fxyd2							V			V
Myh6							V
Adra1b									V
Gnaq									V
Gata4									V
Creb3l3									V
Atp2b2									V
Adcy9									V
Ppif									V
Kng2									V
Ppp1r12a										V
Ppp1ca										V
Myl9										V
Gucy1b1										V
Itpr3										V
Pde5a										V
Rgs2										V
Adra1d										V
Ednra										V
Ednrb										V
Cacna1c										V
Rhoa										V
Rock1										V
Gna11										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Nfatc4										V
Mef2a										V
Map2k1										V
Bad										V
Atf4										V
Creb3l1										V
Vasp										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Akt2										V
Akt3										V
Nos3										V
Adcy4										V
Adcy5										V
Pde3a										V
Prkce										V
Vdac2										V
Vdac3										V
Mylk										V
Calml4										V
Irs3										V
Irs2										V
Adrb1										V
Adrb2										V
Gnai2										V
+ 04151: PI3K-Akt signaling pathway	0.8	1	1.5	1.2	3.7	1.6	1.8	1.9	0.5	6.4
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Gsk3b	V									V
Mdm2	V	V			V					V
Gys2	V								V
Ikbkg	V				V				V	V
Fgf21	V			V	V
Grb2	V	V			V					V
Ppp2r1b	V					V				V
Mapk3	V					V				V
Itga3	V					V	V			V
Reln	V								V
Irs1		V				V
Egfr		V							V
Ccnd1		V			V				V
Rela		V						V	V
Igf1		V	V						V
Hsp90aa1		V					V		V
Hsp90b1		V							V
Itga5		V			V					V
Pik3ap1		V			V			V	V
Pten			V			V				V
Kit			V
Met			V			V			V
Fgf1			V						V
Gnb2			V							V
Lamb1			V			V				V
Rxra			V	V					V
Eif4e2				V		V
Ywhae				V						V
Flt3l				V						V
Cdkn1a				V	V			V		V
Creb3l2				V
Akt1					V					V
Pik3cd					V
Csf1r					V
Ntrk2					V		V	V		V
F2r					V				V
Lpar5					V
Lpar3					V					V
Ywhaq					V					V
Angpt2					V					V
Csf1					V					V
Pdgfa					V					V
Pdgfc					V					V
Ppp2r5b					V					V
Ppp2r5c					V			V		V
Pik3cg					V					V
Pik3r5					V			V		V
Mapk1					V			V		V
Syk					V			V		V
Gng2					V					V
Itga4					V			V		V
Itga6					V					V
Itga7					V					V
Itgb1					V					V
Itgb4					V					V
Col4a1					V					V
Col4a2					V					V
Col6a2					V					V
Col1a1					V					V
Comp					V					V
Fn1					V	V	V	V	V
Spp1					V				V
Thbs1					V					V
Thbs2					V
Thbs4					V
Tnc					V
Ifnar2					V					V
Il2rg					V					V
Il3ra					V					V
Il4ra					V					V
Il7r					V			V		V
Osmr					V			V		V
Brca1					V
Creb3					V					V
Mcl1					V					V
Pkn2					V
Pkn1					V					V
Ccne1					V
Magi1					V				V
Eif4ebp1						V	V			V
Pik3r2						V				V
Cdkn1b						V	V			V
Gys1						V				V
Pck1						V	V
Ywhag						V			V	V
Angpt1						V				V
Fgf10						V				V
Vegfb						V	V			V
Ppp2r3a						V
Stk11						V				V
Crtc2						V				V
Raf1						V		V		V
Gnb1						V				V
Gnb5						V				V
Ptk2						V	V			V
Ghr						V	V			V
Prlr						V			V
Mtor							V			V
Igf2							V			V
Ngf							V
Itgb5							V			V
Bcl2l1								V
Lamc2								V
Sgk1								V		V
Rps6kb1									V
Epha2									V
Erbb3									V
Fgfr3									V
Fgfr4									V
Flt4									V
G6pc									V
Klk1b4									V
Tgfa									V
Sos1									V
Kras									V
Them4									V
Hsp90ab1									V	V
Prkaa2									V
Vtn									V
Ifnar1									V	V
Il6ra									V
Creb3l3									V
Sgk2									V
Eif4e										V
Rps6-ps4										V
Rps6										V
Rps6kb2										V
Rheb										V
Tsc2										V
Akt2										V
Akt3										V
Pik3r3										V
Erbb2										V
Fgfr1										V
Igf1r										V
Tek										V
Lpar1										V
Lpar6										V
Lpar4										V
Myc										V
Bad										V
Pck2										V
G6pc3										V
Chuk										V
Ikbkb										V
Nfkb1										V
Ywhah										V
Ywhaz										V
Ywhab										V
Angpt4										V
Efna2										V
Efna4										V
Efna5										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Vegfd										V
Ntf3										V
Pgf										V
Vegfc										V
Pdgfd										V
Ppp2ca										V
Ppp2cb										V
Ppp2r5a										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r3c										V
Ppp2r2a										V
Ppp2r2b										V
Cdc37										V
Nos3										V
Prkaa1										V
Ddit4										V
Phlpp2										V
Cdk4										V
Casp9										V
Map2k1										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Itga11										V
Itgb7										V
Chad										V
Col4a4										V
Col4a5										V
Col6a1										V
Col1a2										V
Lama2										V
Lama4										V
Lamb2										V
Thbs3										V
Lamc1										V
Col6a6										V
Col6a5										V
Col4a6										V
Tlr4										V
Rac1										V
Epor										V
Il2ra										V
Il2rb										V
Il4										V
Il7										V
Atf4										V
Creb3l1										V
Bcl2										V
Pkn3										V
Sgk3										V
Ccnd2										V
Ccnd3										V
Nr4a1										V
+ 04152: AMPK signaling pathway	4.5	1.6	0.6	2.8	1	5.2	3.2	0.2	2.2	5.5
Prkag2	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Slc2a4	V					V	V			V
Sirt1	V		V	V
Acaca	V					V
Cpt1a	V				V				V
Fbp1	V								V
Akt1s1	V	V				V				V
Gys2	V								V
Srebf1	V			V		V			V	V
Fasn	V			V		V				V
Pparg	V					V				V
Ppp2r1b	V					V				V
Cd36	V				V					V
Irs1		V				V
Igf1		V	V						V
Pfkfb3		V			V		V			V
Ccnd1		V			V				V
Lepr		V							V
Acacb				V		V			V	V
Hmgcr				V					V
Creb3l2				V
Prkab1					V	V			V	V
Akt1					V					V
Pik3cd					V
Pfkfb4					V					V
Tbc1d1					V	V		V		V
Ppp2r5b					V					V
Ppp2r5c					V			V		V
Ccna2					V
Lep					V					V
Creb3					V					V
Pik3r2						V				V
Stk11						V				V
Pfkfb1						V
Adipoq						V	V			V
Gys1						V				V
Pck1						V	V
Eef2k						V				V
Eif4ebp1						V	V			V
Crtc2						V				V
Ppp2r3a						V
Lipe						V	V			V
Prkab2							V			V
Prkag3							V
Mtor							V			V
Rab11b							V			V
Prkaa2									V
Ppargc1a									V
Camkk2									V
Hnf4a									V
G6pc									V
Scd3									V
Eef2									V
Rps6kb1									V
Rab8a									V
Creb3l3									V
Ulk1									V	V
Prkaa1										V
Prkag1										V
Akt2										V
Akt3										V
Pik3r3										V
Irs3										V
Irs2										V
Igf1r										V
Foxo1										V
Adipor1										V
Cpt1c										V
Pfkl										V
Pfkm										V
Pfkp										V
Tsc2										V
Pck2										V
G6pc3										V
Scd2										V
Rps6kb2										V
Cab39										V
Cab39l										V
Ppp2ca										V
Ppp2cb										V
Ppp2r5a										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r3c										V
Ppp2r2a										V
Ppp2r2b										V
Elavl1										V
Rab10										V
Rab14										V
Rheb										V
Creb3l1										V
+ 04150: mTOR signaling pathway	2.3	0.6	0.9	2	0.9	1.8	0.1	0.7	0.6	5.2
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Rps6ka1	V			V	V
Grb2	V	V			V					V
Fnip2	V								V
Akt1s1	V	V				V				V
Gsk3b	V									V
Fzd4	V		V							V
Fzd8	V
Irs1		V				V
Igf1		V	V						V
Pten			V			V				V
Lpin1				V	V				V
Eif4e2				V		V
Lamtor2				V		V
Mapkap1				V					V	V
Pik3cd					V
Mapk1					V			V		V
Akt1					V					V
Rps6ka2					V					V
Tnf					V
Atp6v1a					V			V
Atp6v1b2					V			V		V
Atp6v1c1					V
Deptor					V				V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Dvl1					V					V
Castor2					V					V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Eif4ebp1						V	V			V
Nprl3						V				V
Wnt2b						V				V
Stk11						V				V
Mtor							V			V
Sgk1								V		V
Kras									V
Rps6kb1									V
Prkaa2									V
Ulk1									V	V
Sos1									V
Rnf152									V
Wdr59									V	V
Atp6v1h									V	V
Fnip1									V
Wnt2									V
Wnt5b									V	V
Clip1									V	V
Igf1r										V
Pik3r3										V
Map2k1										V
Akt2										V
Akt3										V
Tsc2										V
Rheb										V
Rps6kb2										V
Rhoa										V
Prkcb										V
Tbc1d7										V
Rragb										V
Rraga										V
Rps6ka3										V
Prkaa1										V
Ddit4										V
Eif4e										V
Rps6-ps4										V
Rps6										V
Ikbkb										V
Tnfrsf1a										V
Slc7a5										V
Slc3a2										V
Sec13										V
Mios										V
Sesn2										V
Atp6v1e1										V
Atp6v1f										V
Atp6v1g2										V
Atp6v1g1										V
Atp6v1d										V
Lamtor3										V
Lamtor4										V
Lamtor1										V
Lamtor5										V
Chuk										V
Flcn										V
Telo2										V
Prr5										V
Wnt9a										V
Wnt6										V
Fzd1										V
Fzd6										V
Fzd2										V
Dvl2										V
Cab39										V
Cab39l										V
Castor1										V
+ 3.3 Signaling molecules and interaction	0.6	1	1	0	6.2	0.2	0.9	3.8	0	4.1
+ 04080: Neuroactive ligand-receptor interaction	0	0	0.3	0	0	0	0.4	0.3	0	0
Pth1r	V					V			V	V
P2ry1	V				V
Chrna2	V								V
Kng1	V								V
Lepr		V							V
Gcgr		V							V
Adora1		V
Avpr1a		V	V			V			V
Thra			V	V		V				V
S1pr5			V						V
P2ry4			V						V
Lep					V					V
P2rx4					V			V		V
P2rx7					V			V
Gabrr2					V		V
Gpr156					V
Vipr2					V
S1pr2					V					V
Lpar3					V					V
Gpr50					V
Ptafr					V					V
Cnr2					V				V	V
P2ry14					V			V
P2ry2					V			V	V
P2ry10b					V			V
P2ry6					V					V
Gpr35					V
Ptgir					V					V
Ptger4					V					V
F2r					V				V
Oxtr					V
C5ar1					V			V		V
C3ar1					V			V		V
Htr2b					V
Cck					V					V
Prlr						V			V
Ghr						V	V			V
Tspo						V	V			V
Grik5						V				V
Ntsr2						V				V
Mc5r						V				V
Adrb3						V				V
Agt						V	V
Penk						V		V		V
Ltb4r1							V			V
Agtr1a							V
Chrnb1							V			V
Apln							V			V
F2									V
Plg									V
Gabbr2									V
Vipr1									V
Pard3									V
Sstr2									V
Fpr1									V
Adra1b									V
Chrna4									V
Kng2									V
C3									V	V
Gzma										V
Kiss1r										V
Trpv1										V
Gria1										V
Grin2d										V
Gria3										V
P2rx6										V
P2rx5										V
Gabre										V
Gabbr1										V
Sctr										V
Gipr										V
Cysltr1										V
S1pr1										V
S1pr3										V
S1pr4										V
Lpar1										V
Lpar4										V
Cnr1										V
Lpar6										V
Adora2a										V
Adora2b										V
Ptger2										V
Tshr										V
F2rl1										V
Npy1r										V
Mc2r										V
Ednra										V
Ednrb										V
Aplnr										V
Adra1d										V
Adrb1										V
Adrb2										V
Nmb										V
Edn1										V
Sst										V
Adm										V
Calca										V
+ 04060: Cytokine-cytokine receptor interaction	0.2	0.9	0.5	0	4	0.1	0.5	3.2	0	2.6
Acvr1	V									V
Il18	V					V				V
Tnfrsf19	V
Fas	V				V					V
Ctf1	V					V				V
Cxcl9	V									V
Gdf15	V			V	V			V	V
Il22ra1		V							V
Lifr		V	V						V
Inhba		V
Cxcl16		V	V					V
Cxcl13		V								V
Tnfrsf12a		V			V			V		V
Ccl9		V			V					V
Bmp6		V					V			V
Lepr		V							V
Tnfrsf14			V
Cxcl12			V		V				V	V
Il20rb					V			V		V
Il10rb					V					V
Il2rg					V					V
Csf2rb					V					V
Csf2rb2					V			V		V
Tgfb1					V					V
Tnfrsf13b					V					V
Il10ra					V					V
Ifnar2					V					V
Il10					V
Crlf2					V					V
Il7r					V			V		V
Il4ra					V					V
Il3ra					V					V
Csf2ra					V					V
Il13ra1					V				V
Cntfr					V	V	V			V
Osmr					V			V		V
Cx3cr1					V
Cxcr4					V			V		V
Cxcl14					V					V
Cxcl10					V	V		V		V
Tnfrsf1b					V
Tnfrsf21					V					V
Tnfrsf11a					V			V		V
Tnfsf12					V					V
Tnf					V
Cxcl2					V
Ccl4					V			V
Ccl3					V			V
Ccr1					V			V		V
Ccl6					V			V		V
Ccl7					V			V		V
Ccl2					V			V		V
Ccl22					V					V
Ccl8					V					V
Il27ra					V					V
Il1rn					V			V
Csf1					V					V
Csf1r					V
Gdf3					V			V
Bmp3					V					V
Mstn					V
Gdf6					V
Lep					V					V
Il13ra2					V			V
Ifngr1						V				V
Prlr						V			V
Ghr						V	V			V
Il17rb						V
Ccl24						V				V
Ccl27a						V				V
Tnfrsf25						V				V
Acvr1c						V				V
Gdf10						V				V
Bmp4						V				V
Ltb							V
Il17re							V			V
Ackr4							V			V
Ngf							V
Il1rap									V
Il1b									V
Il1a									V
Bmp2									V
Inhbe									V
Inhbc									V
Ifnar1									V	V
Il15ra									V	V
Thpo									V
Il12rb1									V
Il6ra									V
Klk1b4									V
Gdf2									V
Bmp10									V
Il4										V
Bmpr2										V
Il2rb										V
Il18r1										V
Il1r1										V
Bmpr1a										V
Amhr2										V
Tgfbr2										V
Gdf5										V
Bmp7										V
Inhbb										V
Tgfb3										V
Tgfb2										V
Relt										V
Tnfrsf18										V
Cd40										V
Tnfsf9										V
Ifngr2										V
Epor										V
Il21r										V
Il2ra										V
Tslp										V
Il7										V
Gm2002										V
Gm13305										V
Il11ra2										V
Il11ra1										V
Cxcr3										V
Cx3cl1										V
Pf4										V
Tnfrsf1a										V
Tnfrsf10b										V
Tnfsf10										V
Ackr3										V
Il17d										V
LOC100041504										V
LOC100041593										V
Ccl21b										V
Gm10591										V
Gm13304										V
Ccl21d										V
Ccl21c										V
Gm1987										V
Ccl21a										V
Gm2023										V
Ccl19										V
Ccl11										V
Ccr2										V
Ccr10										V
Ccl25										V
Ccl12										V
Ccl5										V
Il33										V
Il1rl1										V
Il34										V
Inha										V
Acvrl1										V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	0.2	0.7	0.8	0	4.1	0.1	0.1	3	0	3.9
Cxcl9	V									V
Il18	V					V				V
Ccl9		V			V					V
Cxcl13		V								V
Il22ra1		V							V
Cxcl12			V		V				V	V
Tnfrsf14			V
Ccl3					V			V
Ccl6					V			V		V
Ccl7					V			V		V
Ccl8					V					V
Ccr1					V			V		V
Ccl2					V			V		V
Ccl22					V					V
Ccl4					V			V
Cx3cr1					V
Cxcl2					V
Cxcl10					V	V		V		V
Cxcr4					V			V		V
Cxcl14					V					V
Il10rb					V					V
Il10ra					V					V
Il10					V
Il2rg					V					V
Il20rb					V			V		V
Csf1					V					V
Csf1r					V
Tnfrsf1b					V
Tnf					V
Ccl27a						V				V
Ccl24						V				V
Ackr4							V			V
Il6ra									V
Ccl5										V
Ccl12										V
Ccr2										V
Ccl11										V
Ccl25										V
Ccr10										V
Gm2023										V
Ccl19										V
LOC100041504										V
LOC100041593										V
Ccl21b										V
Gm10591										V
Gm13304										V
Ccl21d										V
Ccl21c										V
Gm1987										V
Ccl21a										V
Cx3cl1										V
Pf4										V
Cxcr3										V
Ackr3										V
Il2rb										V
Il2ra										V
Il18r1										V
Il34										V
Tnfrsf1a										V
Tnfrsf10b										V
Tnfsf10										V
+ 04512: ECM-receptor interaction	0.7	0.4	0.4	0	4.2	0.1	0.8	1.1	0.1	1.8
Cd36	V				V					V
Itga3	V					V	V			V
Reln	V								V
Sdc4		V							V
Itga5		V			V					V
Lamb1			V			V				V
Col4a1					V					V
Col4a2					V					V
Col6a2					V					V
Col1a1					V					V
Dag1					V					V
Tnc					V
Spp1					V				V
Fn1					V	V	V	V	V
Comp					V					V
Thbs1					V					V
Thbs2					V
Thbs4					V
Itgb1					V					V
Itga6					V					V
Itga4					V			V		V
Hmmr					V
Sdc1					V				V
Itgb4					V					V
Itga7					V					V
Cd44					V			V
Itgb5							V			V
Lamc2								V
Vtn									V
Lama2										V
Lama4										V
Lamb2										V
Lamc1										V
Col4a4										V
Col4a5										V
Col6a1										V
Col1a2										V
Col6a6										V
Col6a5										V
Col4a6										V
Thbs3										V
Sv2a										V
Itgb7										V
Itga11										V
Npnt										V
Chad										V
+ 4. Cellular Processes	6.9	6	3	5.9	16.3	4.4	4.3	10.5	7.2	17.7
+ 4.1 Transport and catabolism	5.9	5.6	2.2	5	10	3.3	2.9	8.6	9.2	11
+ 04144: Endocytosis	3	2.6	1.4	0.5	5.6	0.1	0.4	3.2	3	6.9
Mdm2	V	V			V					V
Smurf1	V									V
Clta	V							V		V
Chmp6	V									V
Chmp2a	V	V							V	V
Epn1	V				V				V	V
Sh3glb2	V					V	V		V	V
Grk2	V				V					V
Grk6	V									V
Arrb1	V				V					V
Eea1	V			V						V
Zfyve16	V									V
Zfyve9	V		V
Washc2	V	V						V	V
Washc3	V									V
Rab22a	V
Wipf3	V		V			V
Cltc		V								V
Ap2a1		V								V
Vps37c		V		V					V
Eps15		V							V
Eps15l1		V							V
Egfr		V							V
Asap2		V
Agap2		V								V
Chmp7		V
Vps26a		V							V	V
Rab11fip4		V								V
Itch			V		V				V
Nedd4			V
Ap2b1			V
Rab11fip1			V						V
Ldlr				V	V			V	V	V
Spg20				V		V
Stam2					V					V
Dnm1					V					V
Wwp1					V				V
Cbl					V
Rnf41					V					V
Ap2m1					V				V
Hspa8					V			V	V	V
Dnajc6					V
Tsg101					V	V				V
Arf6					V
Rab5c					V					V
Ldlrap1					V
Dab2					V			V		V
Cxcr4					V			V		V
Sh3kbp1					V					V
Grk5					V					V
Arrb2					V				V	V
Rab11fip5					V					V
Pip5k1c					V				V
Psd4					V
Iqsec1					V					V
Cyth4					V			V
Arfgef2					V
Arfgap1					V					V
Asap3					V
Arfgap3					V					V
Arap1					V			V		V
Smap2					V
Acap2					V					V
Ehd4					V			V		V
H2-K1					V				V	V
H2-M2					V
H2-Q4					V					V
Rab7					V					V
Smad2					V					V
Cav1					V		V			V
Il2rg					V					V
Washc5					V					V
Capza2					V					V
Capzb					V					V
Rab31					V			V		V
Rab11fip3					V
Arpc1b					V			V		V
Arpc5					V			V		V
Arpc4					V					V
Arpc2					V				V	V
Snx5					V			V		V
Igf2r					V
Wipf1					V
Hgs						V
Chmp3						V				V
Pard6b						V
Pard6g						V	V			V
Sh3glb1						V				V
Iqsec2						V				V
H2-Q10						V			V
Snx32						V				V
Src							V	V
Rab11b							V			V
Cyth1							V
Vps25								V	V	V
Rufy1								V
H2-D1								V		V
Smurf2									V
Cblc									V
Mvb12a									V
Vps37b									V
Vps37a									V	V
Snf8									V
Pdcd6ip									V	V
Prkcz									V	V
Pard3									V
Tfrc									V
Fgfr3									V
Fgfr4									V
Rabep1									V
Arfgef1									V
Arfgap2									V
Ehd3									V
Rab4a									V
H2-Q7									V
H2-T23									V
Pml									V
Rab8a									V
Snx2									V	V
Ist1									V	V
Stambp										V
Dnm2										V
Cblb										V
Cltb										V
Ap2s1										V
Mvb12b										V
Vps37d										V
Vps28										V
Hspa2										V
Hspa1a										V
Chmp4b										V
Chmp1a										V
Chmp2b										V
Vps4a										V
Vta1										V
Chmp5										V
Cdc42										V
Prkci										V
Pard6a										V
Rab11a										V
Epn2										V
Igf1r										V
Sh3gl2										V
Sh3gl1										V
Grk3										V
Rab11fip2										V
Pld2										V
Pip5k1b										V
Cyth2										V
Cyth3										V
Psd										V
Asap1										V
Acap3										V
Git2										V
Smap1										V
Ehd1										V
Ehd2										V
Rbsn										V
Vps45										V
H2-M3										V
H2-T22										V
Tgfbr2										V
Cav2										V
Il2ra										V
Il2rb										V
Rhoa										V
Folr1										V
Folr2										V
Arf3										V
Zfyve27										V
Kif5a										V
Kif5c										V
Washc1										V
Rab35										V
Rab10										V
Snx4										V
Vps26b										V
Vps29										V
Vps35										V
Amph										V
Spg21										V
Arpc3										V
Arpc1a										V
Snx3										V
Snx12										V
Snx1										V
Snx6										V
Ubb										V
+ 04145: Phagosome	1.4	3.5	0.4	3.4	7.4	0	0.2	5	2.7	4.3
Eea1	V			V						V
Cd36	V				V					V
Colec11	V								V
Gm4184	V	V		V					V
Gm11575	V	V		V					V
Sec61g	V	V		V					V
Tap1	V									V
Tap2	V	V								V
Stx18		V							V	V
Fcgr2b		V			V				V	V
C1rb		V	V
Itga5		V			V					V
Tuba4a		V				V			V
Tuba8		V							V
Tubb5		V			V			V		V
Tubb4b		V		V
Calr		V		V	V				V
Pik3c3			V			V				V
Dync1li2				V	V				V	V
Tuba1b				V						V
Tubb2a				V
Sec61a1				V
Fcgr1					V			V		V
Fcgr4					V				V
Itgam					V					V
Itgb2					V			V
Itgb1					V					V
Mrc1					V			V		V
Mrc2					V
Msr1					V			V	V
Actb					V					V
Rab5c					V					V
Rab7					V					V
Rab7b					V					V
Cybb					V			V		V
Cyba					V					V
Ncf4					V					V
Ncf1					V					V
Ncf2					V					V
Tuba1c					V					V
Tubb6					V			V		V
Tubb2b					V			V		V
Atp6v0b					V					V
Atp6v1a					V			V
Atp6v1b2					V			V		V
Atp6v0a1					V			V		V
Atp6v0c					V					V
Atp6v0d2					V			V
Tcirg1					V			V	V
Atp6ap1					V					V
Atp6v1c1					V
Olr1					V
Tlr6					V			V
Comp					V					V
Thbs1					V					V
Thbs2					V
Thbs4					V
H2-Aa					V					V
H2-Ab1					V					V
H2-Eb1					V					V
H2-DMb1					V					V
Ctsl					V			V	V
Ctss					V					V
H2-K1					V				V	V
H2-M2					V
H2-Q4					V					V
Coro1a					V					V
C1ra						V
Hgs						V
Atp6v0e2						V				V
H2-Q10						V			V
Itgb5							V			V
Atp6v0a2							V			V
Cd209b							V			V
M6pr								V		V
Cd14								V		V
Cd209g								V		V
H2-D1								V		V
Itgb2l									V
Rilp									V
Dync1i2									V	V
Atp6v1h									V	V
Lamp2									V
Marco									V
Scarb1									V	V
C3									V	V
Mbl1									V
Mbl2									V
Canx									V
H2-Q7									V
H2-T23									V
Tfrc									V
Vamp3										V
Pla2r1										V
Actg1										V
Rac1										V
Dync1h1										V
Dync1li1										V
Tuba1a										V
Tubb3										V
Tubb4a										V
Atp6v0d1										V
Atp6v1e1										V
Atp6v1f										V
Atp6v1g2										V
Atp6v1g1										V
Atp6v1d										V
Stx12										V
Tlr4										V
Thbs3										V
Sec61a2										V
H2-DMb2										V
Cd209c										V
Cd209d										V
Cd209a										V
H2-M3										V
H2-T22										V
+ 04142: Lysosome	0.6	1.6	0.6	2.4	8	0.4	0.8	7.1	2.8	6.5
Gaa	V			V						V
Hexb	V									V
Aga	V									V
Clta	V							V		V
Ctsd		V			V			V		V
Arsa		V		V					V	V
Gm2a		V			V
Cltc		V								V
Ap1g1		V	V						V
Ap3s1		V								V
Naga			V	V	V					V
Lipa				V	V			V	V
Ap3d1				V						V
Ap4m1				V
Atp6v0b					V					V
Atp6v0a1					V			V		V
Atp6v0c					V					V
Atp6v0d2					V			V
Tcirg1					V			V	V
Atp6ap1					V					V
Ctsb					V			V		V
Ctsh					V				V
Ctsk					V					V
Ctsl					V			V	V
Ctss					V					V
Ctsa					V	V		V	V	V
Ctsz					V
Lgmn					V			V		V
Tpp1					V				V
Glb1					V					V
Gba					V					V
Hexa					V					V
Manba					V
Gusb					V			V		V
Galc					V			V		V
Idua					V		V			V
Galns					V			V		V
Pla2g15					V			V		V
Dnase2a					V				V
Acp2					V			V	V	V
Asah1					V					V
Gnptab					V					V
Psap					V					V
Cd68					V			V		V
Cd63					V			V		V
Laptm5					V					V
Slc11a1					V			V		V
Npc1					V			V	V
Npc2					V			V		V
Cln5					V
Igf2r					V
Ap1s2					V					V
Ap1g2					V					V
Ap3m2					V					V
Hyal1					V				V
Ctsc						V				V
Ctsf						V				V
Ppt2						V				V
Hgsnat						V			V	V
Acp5						V	V	V		V
Ap4s1						V				V
Atp6v0a2							V			V
Nagpa							V			V
Man2b1								V
M6pr								V		V
Atp6v1h									V	V
Arsg									V
Gns									V
Dnase2b									V
Lamp2									V
Scarb2									V
Ctns									V	V
Slc17a5									V
Slc11a2									V	V
Ap3m1									V
Mcoln1									V	V
Atp6v0d1										V
Ctso										V
Napsa										V
Neu1										V
Naglu										V
Fuca1										V
Arsb										V
Ids										V
Smpd1										V
Ppt1										V
Laptm4b										V
Laptm4a										V
Abcb9										V
Cln3										V
Cltb										V
Ap1b1										V
Ap1m1										V
Ap1s1										V
Gga2										V
Sumf1										V
Litaf										V
+ 04146: Peroxisome	6.5	1.8	1.5	1.9	0.5	4.8	2.7	1.2	8.6	1.2
Pex7	V
Pex19	V						V	V	V
Pex11a	V					V			V
Pex11b	V
Acaa1a	V								V	V
Acaa1b	V			V					V
Acox1	V							V	V	V
Scp2	V	V		V		V			V
Crat	V									V
Dhrs4	V						V		V
Pecr	V					V			V
Eci2	V					V			V	V
Nudt12	V								V
Abcd1	V				V					V
Abcd2	V					V				V
Idh1	V								V
Hao2	V
Gstk1	V					V
Hacl1		V							V
Acsl4		V							V
Prdx1		V							V
Nudt7		V							V
Phyh			V			V			V
Acsl1			V		V				V	V
Mpv17			V		V	V	V			V
Abcd3				V				V	V
Acsl3				V					V
Pex5l					V
Agps					V					V
Acsl5					V					V
Far1					V					V
Sod2					V				V
Pex6						V
Pex11g						V			V	V
Pex3						V				V
Amacr						V			V
Ech1						V				V
Paox						V				V
Ddo						V
Eci3						V	V			V
Xdh						V		V		V
Sod1						V
Pxmp2						V	V		V
Pex16							V
Acox3							V		V
Pex2									V	V
Pex26									V	V
Pex5									V	V
Gnpat									V	V
Acox2									V
Cat									V
Pipox									V
Agxt									V
Crot									V
Baat									V
Hmgcl									V
Acot8									V
Decr2									V
Slc27a2									V
Hao1									V
Ephx2									V
Mpv17l									V
Pex13										V
Pex10										V
Pex12										V
Mvk										V
Idh2										V
Prdx5										V
Nos2										V
Mpv17l2										V
Pxmp4										V
+ 04140: Autophagy - animal	1.5	3.3	0.5	2.2	2.2	2.4	1.5	2.7	3.1	4.7
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Akt1s1	V	V				V				V
Wipi1	V	V		V			V			V
Mapk8	V
Ambra1	V	V							V
Irs1		V				V
Atg13		V							V	V
Rb1cc1		V								V
Mtmr4		V			V		V		V
Dapk3		V				V
Atg16l2		V							V
Ctsd		V			V			V		V
Vmp1		V			V	V			V	V
Pten			V			V				V
Pik3c3			V			V				V
Itpr1				V						V
Eif2ak3				V
Atg7				V						V
Vamp8				V
Pik3cd					V
Akt1					V					V
Mapk1					V			V		V
Hif1a					V			V	V
Prkcd					V			V		V
Deptor					V				V
Atg2a					V					V
Ern1					V				V
Becn1					V					V
Uvrag					V				V
Atg12					V					V
Cflar					V				V	V
Rab7					V					V
Rab7b					V					V
Ctsl					V			V	V
Ctsb					V			V		V
Sqstm1					V	V			V
Tank					V			V		V
Pik3r2						V				V
Rras						V				V
Raf1						V		V		V
Bnip3						V	V			V
Stk11						V				V
Sh3glb1						V				V
Mtor							V			V
Mtmr14							V			V
Dapk2							V
Bcl2l1								V
Pik3r4								V		V
Kras									V
Rps6kb1									V
Igbp1									V	V
Ulk1									V	V
Atg101									V
Prkaa2									V
Camkk2									V
Atg9a									V
Zfyve1									V
Atg3									V
Atg4d									V
Lamp2									V
Rab1a									V
Rab8a									V
Tbk1									V
Igf1r										V
Irs3										V
Irs2										V
Pik3r3										V
Akt2										V
Akt3										V
Mras										V
Rras2										V
Map2k1										V
Ddit4										V
Tsc2										V
Rheb										V
Rps6kb2										V
Ppp2ca										V
Ppp2cb										V
Rragb										V
Rraga										V
Prkaa1										V
Mapk9										V
Prkaca										V
Bcl2										V
Rubcn										V
Bad										V
Gm21596										V
Hmgb1										V
Dapk1										V
Rab33b										V
Atg10										V
Atg16l1										V
Gabarap										V
Gabarapl2										V
Atg4a										V
Wdr41										V
+ 04136: Autophagy - other	0.5	1.3	0.9	1.7	0.5	0.2	1.3	0.5	1.5	2.8
Wipi1	V	V		V			V			V
Atg13		V							V	V
Pik3c3			V			V				V
Atg7				V						V
Becn1					V					V
Atg2a					V					V
Atg12					V					V
Mtor							V			V
Pik3r4								V		V
Atg101									V
Igbp1									V	V
Atg9a									V
Atg3									V
Atg4d									V
Ppp2ca										V
Ppp2cb										V
Gabarap										V
Gabarapl2										V
Atg4a										V
Atg16l1										V
Atg10										V
+ 04137: Mitophagy - animal	2	0.7	0.5	1.1	2.4	0.9	0.7	3.1	2.7	2.7
Mfn2	V									V
Ambra1	V	V							V
Tbc1d17	V					V				V
Mapk8	V
Jun	V									V
Rela		V						V	V
Tfe3			V		V			V
Csnk2b				V				V	V
Eif2ak3				V
Optn					V				V	V
Sqstm1					V	V			V
Csnk2a1					V				V
Csnk2a2					V
Becn1					V					V
Tfeb					V			V
Rab7					V					V
Rab7b					V					V
Bcl2l13					V					V
Hif1a					V			V	V
E2f1					V					V
Bnip3						V	V			V
Rras						V				V
Cited2						V				V
Src							V	V
Bcl2l1								V
Tbk1									V
Nbr1									V
Ulk1									V	V
Rhot1									V	V
Atg9a									V
Tbc1d15									V
Kras									V
Pink1										V
Prkn										V
Gabarap										V
Gabarapl2										V
Fundc1										V
Rhot2										V
Tomm7										V
Mitf										V
Tax1bp1										V
Fis1										V
Atf4										V
Mras										V
Rras2										V
Mapk9										V
Ubb										V
+ 4.2 Cell growth and death	3.8	1.7	1.8	4.6	10.5	1.9	1.5	5	2.1	11.2
+ 04110: Cell cycle	1.3	0.5	0	0.9	5.6	0.6	0.8	1.8	0	5.6
Mcm6	V			V	V			V		V
Orc4	V				V
Orc5	V									V
Mdm2	V	V			V					V
Wee1	V
Gsk3b	V									V
Ccnd1		V			V				V
Stag2		V
Ywhae				V						V
Cdkn1a				V	V			V		V
Mcm3					V					V
Mcm2					V
Mcm5					V			V		V
Rbx1					V			V		V
Cdk1					V
Bub1b					V
Pcna					V			V		V
Plk1					V
Mad2l1					V
Bub1					V
Bub3					V					V
Ywhaq					V					V
Gadd45a					V					V
Gadd45b					V			V		V
Tgfb1					V					V
Smad4					V					V
Smad2					V					V
Cdc7					V					V
Cdc20					V
Cdc6					V
Ccnb2					V
Ccnb1					V
Ccna2					V
Ccnh					V					V
Ccne1					V
Ttk					V
Cdkn2d					V					V
Tfdp1					V					V
E2f1					V					V
Anapc13						V				V
Skp1a						V	V		V	V
Ywhag						V			V	V
Sfn						V				V
Pttg1						V				V
Gadd45g						V				V
Cdkn1b						V	V			V
Cdkn2c						V	V			V
Chek2							V			V
Abl1								V		V
Orc3									V
E2f4									V
Mcm4										V
Mcm7										V
Orc6										V
Anapc1										V
Cdc27										V
Anapc4										V
Cdc23										V
Anapc5										V
Anapc11										V
Cdc16										V
Anapc2										V
Cul1										V
Cdc14a										V
Ywhah										V
Ywhaz										V
Ywhab										V
Prkdc										V
Pkmyt1										V
Smc1a										V
Rb1										V
Cdkn1c										V
Cdkn2b										V
Tgfb2										V
Tgfb3										V
Cdc25b										V
Cdk7										V
Cdk4										V
Ccnd2										V
Ccnd3										V
Smc3										V
Rad21										V
Rbl1										V
Myc										V
Zbtb17										V
Tfdp2										V
Hdac1										V
+ 04114: Oocyte meiosis	0.7	0.1	0.7	1.5	3.7	0.7	0.2	0.4	0	5.1
Rps6ka1	V			V	V
Mapk3	V					V				V
Adcy6	V					V				V
Ppp2r1b	V					V				V
Igf1		V	V						V
Mapk14			V	V	V				V
Itpr1				V						V
Ywhae				V						V
Cdk1					V
Mad2l1					V
Ccnb2					V
Rps6ka2					V					V
Mapk1					V			V		V
Cdc20					V
Ccnb1					V
Rbx1					V			V		V
Ccne1					V
Plk1					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Adcy3					V					V
Adcy7					V
Ywhaq					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Mapk12					V					V
Sgo1					V
Ppp2r5b					V					V
Ppp2r5c					V			V		V
Bub1					V
Anapc13						V				V
Pttg1						V				V
Skp1a						V	V		V	V
Ywhag						V			V	V
Ar						V				V
Ppp3ca							V			V
Adcy9									V
Slk									V	V
Pkmyt1										V
Rps6ka3										V
Map2k1										V
Anapc1										V
Cdc27										V
Anapc4										V
Cdc23										V
Anapc5										V
Anapc11										V
Cdc16										V
Anapc2										V
Fbxo5										V
Cul1										V
Btrc										V
Camk2d										V
Camk2a										V
Camk2g										V
Itpr3										V
Calml4										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Cpeb1										V
Prkaca										V
Adcy4										V
Adcy5										V
Ywhah										V
Ywhaz										V
Ywhab										V
Ppp1ca										V
Mapk11										V
Smc1a										V
Ppp2r5a										V
Ppp2ca										V
Ppp2cb										V
Ppp2r1a										V
Smc3										V
Igf1r										V
+ 04210: Apoptosis	2.2	0.7	0	2.6	5	0.9	0.2	3.1	0.2	5.7
Casp6	V									V
Bid	V
Ikbkg	V				V				V	V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Fas	V				V					V
Mapk8	V
Jun	V									V
Mapk3	V					V				V
Rela		V						V	V
Ctsd		V			V			V		V
Tuba4a		V				V			V
Tuba8		V							V
Nfkbia				V				V		V
Diablo				V
Ddit3				V	V					V
Eif2ak3				V
Itpr1				V						V
Tuba1b				V						V
Birc5					V
Casp8					V					V
Akt1					V					V
Cflar					V				V	V
Pik3cd					V
Ripk1					V
Csf2rb					V					V
Csf2rb2					V			V		V
Il3ra					V					V
Tnf					V
Lmna					V				V	V
Lmnb1					V
Bax					V			V		V
Ern1					V				V
Gadd45a					V					V
Gadd45b					V			V		V
Bcl2a1d					V					V
Daxx					V					V
Fos					V					V
Ctsb					V			V		V
Ctsh					V				V
Ctsk					V					V
Ctsl					V			V	V
Ctss					V					V
Ctsz					V
Actb					V					V
Tuba1c					V					V
Mcl1					V					V
Mapk1					V			V		V
Endog						V
Pik3r2						V				V
Gadd45g						V				V
Ctsc						V				V
Ctsf						V				V
Raf1						V		V		V
Capn1							V
Ngf							V
Bcl2l1								V
Xiap									V
Parp3									V	V
Kras									V
Dffa										V
Bcl2										V
Birc3										V
Casp9										V
Casp7										V
Bad										V
Nfkb1										V
Apaf1										V
Capn2										V
Akt2										V
Akt3										V
Map3k14										V
Chuk										V
Ikbkb										V
Pik3r3										V
Traf2										V
Fadd										V
Tnfrsf1a										V
Tnfrsf10b										V
Tnfsf10										V
Parp2										V
Parp4										V
Htra2										V
Bak1										V
Pmaip1										V
Casp12										V
Bcl2a1b										V
Traf1										V
Mapk9										V
Ctso										V
Atf4										V
Itpr3										V
Casp2										V
Actg1										V
Tuba1a										V
Map2k1										V
+ 04215: Apoptosis - multiple species	1.8	0	0	1.6	1.3	0	0	1.2	0	2.3
Birc6	V			V	V					V
Mapk8	V
Bid	V
Diablo				V
Birc5					V
Bax					V			V		V
Becn1					V					V
Casp8					V					V
Bcl2l1								V
Xiap									V
Casp7										V
Apaf1										V
Bok										V
Casp9										V
Birc3										V
Htra2										V
Bak1										V
Bcl2										V
Fadd										V
Tnfrsf1a										V
Mapk9										V
Pmaip1										V
+ 04216: Ferroptosis	0.9	1.1	1.6	3.4	2.4	0.7	1.1	2.7	4.3	3.1
Prnp	V									V
Lpcat3	V								V	V
Slc39a14		V							V
Acsl4		V							V
Pcbp2			V		V			V	V	V
Acsl1			V		V				V	V
LOC100862446				V	V				V
Ftl1				V	V				V
Fth1				V				V		V
Atg7				V						V
Acsl3				V					V
Steap3					V			V		V
Sat1					V					V
Hmox1					V			V		V
Cybb					V			V		V
Acsl5					V					V
Gpx4						V				V
Cp						V			V
Alox15						V				V
Slc40a1							V		V
Ncoa4							V			V
Gclc									V
Gclm									V
Tfrc									V
Gss									V
Slc11a2									V	V
Vdac2										V
Vdac3										V
Slc3a2										V
Slc39a8										V
Map1lc3a										V
Map1lc3b										V
Sat2										V
+ 04217: Necroptosis	1.3	0.7	0.1	0.6	3.1	0.4	0.7	0.8	1	2.2
Fas	V				V					V
Stat1	V				V				V	V
Glul	V					V				V
Mapk8	V
Bid	V
Chmp6	V									V
Chmp2a	V	V							V	V
Vdac1	V									V
Stat3		V			V			V
Hsp90aa1		V					V		V
Chmp7		V
Ppid		V							V
Tlr3			V
LOC100862446				V	V				V
Ftl1				V	V				V
Fth1				V				V		V
Tnf					V
Ifnar2					V					V
Casp8					V					V
Cflar					V				V	V
Ripk1					V
Ripk3					V					V
Ticam2					V					V
Stat5b					V
Stat6					V					V
Dnm1l					V					V
Pycard					V					V
Casp1					V			V		V
H2ac6					V
H2ac7					V
H2ac8					V
H2ac11					V
Hist1h2an					V
Hist1h2ap					V
H2ac4					V
H2ac13					V
Hist1h2ao					V
H2az1					V					V
Bax					V			V		V
Cybb					V			V		V
Sqstm1					V	V			V
Ifngr1						V				V
Sharpin						V	V		V
Rbck1						V
Pygb						V	V			V
Slc25a4						V				V
Slc25a5						V			V	V
Chmp3						V				V
Alox15						V				V
Stat5a							V			V
Capn1							V
Tnfaip3								V
Ifnar1									V	V
Tyk2									V
Xiap									V
Stat2									V
Il1a									V
Hsp90ab1									V	V
Zbp1									V
Spata2l									V
Pygl									V
Glud1									V
Il1b									V
Parp3									V	V
Tnfrsf1a										V
Traf2										V
Mlkl										V
Tlr4										V
Ifngr2										V
Tnfrsf10b										V
Tnfsf10										V
Birc3										V
Fadd										V
Faf1										V
Il33										V
Gm21596										V
Hmgb1										V
Usp21										V
Pygm										V
Smpd1										V
Mapk9										V
Capn2										V
H2ax										V
H2aj										V
Macroh2a1										V
Macroh2a2										V
H2az2										V
Parp2										V
Parp4										V
Bcl2										V
Ppia										V
Pla2g4a										V
Camk2d										V
Camk2a										V
Camk2g										V
Vps4a										V
Chmp1a										V
Chmp2b										V
Chmp4b										V
Chmp5										V
Vdac2										V
Vdac3										V
+ 04115: p53 signaling pathway	1.3	1.1	1.1	1	4.7	1	0.6	2.8	0.1	3.5
Bid	V
Fas	V				V					V
Mdm2	V	V			V					V
Perp	V					V			V
Igf1		V	V						V
Ccnd1		V			V				V
Pten			V			V				V
Cdkn1a				V	V			V		V
Sesn1				V						V
Gadd45a					V					V
Gadd45b					V			V		V
Ccne1					V
Ccng1					V					V
Ccng2					V	V				V
Rrm2					V				V
Steap3					V			V		V
Thbs1					V					V
Serpine1					V			V		V
Gtse1					V
Bax					V			V		V
Casp8					V					V
Cdk1					V
Shisa5					V		V	V		V
Ccnb2					V
Ccnb1					V
Gorab					V
Gadd45g						V				V
Sfn						V				V
Aifm2						V				V
Chek2							V			V
Bcl2l1								V
Ei24									V	V
Siah1a										V
Igfbp3										V
Tsc2										V
Ppm1d										V
Rrm2b										V
Ddb2										V
Zmat3										V
Apaf1										V
Casp9										V
Cdk4										V
Ccnd2										V
Ccnd3										V
Sesn2										V
Pmaip1										V
Siva1										V
Bcl2										V
+ 04218: Cellular senescence	1	0.7	1.6	1.4	4.1	1.2	0.7	1.2	0.3	4.1
Mdm2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Sirt1	V		V	V
Mapk3	V					V				V
Map2k6	V		V		V
Vdac1	V									V
Ccnd1		V			V				V
Rbbp4		V							V
Rela		V						V	V
Ppid		V							V
Mapk14			V	V	V				V
Map2k3			V
Pten			V			V				V
Cdkn1a				V	V			V		V
Itpr1				V						V
Rassf5					V				V
Ppp1cc					V					V
Ppp1ccb					V					V
Pik3cd					V
Akt1					V					V
Mapk1					V			V		V
Ccne1					V
E2f1					V					V
Mapk12					V					V
Ccna2					V
Mybl2					V
Lin54					V
Rad50					V					V
Gadd45a					V					V
Gadd45b					V			V		V
Cdk1					V
Ccnb2					V
Ccnb1					V
Sqstm1					V	V			V
Cacna1d					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Nfatc1					V					V
Tgfb1					V					V
Smad2					V					V
Serpine1					V			V		V
H2-K1					V				V	V
H2-M2					V
H2-Q4					V					V
Pik3r2						V				V
Rras						V				V
Raf1						V		V		V
Gadd45g						V				V
Rad9b						V				V
Eif4ebp1						V	V			V
H2-Q10						V			V
Slc25a4						V				V
Slc25a5						V			V	V
Mtor							V			V
Chek2							V			V
Capn1							V
Ppp3ca							V			V
H2-D1								V		V
Hipk1									V
Kras									V
E2f4									V
Gata4									V
Il1a									V
H2-Q7									V
H2-T23									V
Ppp1ca										V
Myc										V
Pik3r3										V
Akt2										V
Akt3										V
Tsc2										V
Rheb										V
Mras										V
Rras2										V
Map2k1										V
Cdk4										V
Ccnd2										V
Ccnd3										V
Rb1										V
Rbl1										V
Mapk11										V
Rad9a										V
Nfkb1										V
Traf3ip2										V
Mapkapk2										V
Zfp36l2										V
Capn2										V
Calml4										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Nfatc4										V
Itpr3										V
Trpv4										V
Tgfb2										V
Tgfb3										V
Foxo1										V
Btrc										V
Tgfbr2										V
Igfbp3										V
H2-M3										V
H2-T22										V
Cdkn2b										V
Vdac2										V
Vdac3										V
+ 4.3 Cellular community - eukaryotes	3	4.3	1.7	1.8	5.9	2.8	2.9	3.5	2.8	8.2
+ 04510: Focal adhesion	2.4	0.8	1	0.2	4.5	1.3	1.8	1.3	0.1	6.1
Itga3	V					V	V			V
Diaph1	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Reln	V								V
Mapk3	V					V				V
Grb2	V	V			V					V
Rapgef1	V	V							V
Mapk8	V
Jun	V									V
Ctnnb1	V				V					V
Gsk3b	V									V
Itga5		V			V					V
Ccnd1		V			V				V
Egfr		V							V
Igf1		V	V						V
Pten			V			V				V
Lamb1			V			V				V
Met			V			V			V
Zyx				V	V				V
Itgb1					V					V
Itgb4					V					V
Itga4					V			V		V
Itga6					V					V
Itga7					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Akt1					V					V
Parvb					V					V
Pik3cd					V
Tln1					V					V
Pip5k1c					V				V
Actn1					V					V
Actn4					V	V				V
Col4a1					V					V
Col4a2					V					V
Col6a2					V					V
Col1a1					V					V
Comp					V					V
Fn1					V	V	V	V	V
Spp1					V				V
Thbs1					V					V
Thbs2					V
Thbs4					V
Tnc					V
Cav1					V		V			V
Mapk1					V			V		V
Pdgfa					V					V
Pdgfc					V					V
Shc2					V					V
Rap1b					V					V
Rac2					V					V
Vav1					V			V
Vav3					V					V
Actb					V					V
Ilk						V	V			V
Pik3r2						V				V
Ptk2						V	V			V
Fyn						V				V
Braf						V
Raf1						V		V		V
Vegfb						V	V			V
Itgb5							V			V
Myl2							V
Src							V	V
Lamc2								V
Rap1a								V		V
Arhgap5									V
Arhgap35									V
Vtn									V
Xiap									V
Sos1									V
Flt4									V
Itgb7										V
Itga11										V
Flnc										V
Cdc42										V
Mylk										V
Myl12b										V
Myl9										V
Ppp1r12a										V
Ppp1ca										V
Ppp1r12c										V
Ppp1r12b										V
Rock1										V
Akt2										V
Akt3										V
Parva										V
Vcl										V
Vasp										V
Pik3r3										V
Capn2										V
Prkcb										V
Rhoa										V
Chad										V
Col4a4										V
Col4a5										V
Col6a1										V
Col1a2										V
Lama2										V
Lama4										V
Lamb2										V
Thbs3										V
Lamc1										V
Col6a6										V
Col6a5										V
Col4a6										V
Cav2										V
Birc3										V
Bad										V
Bcl2										V
Elk1										V
Ccnd2										V
Ccnd3										V
Map2k1										V
Erbb2										V
Igf1r										V
Vegfd										V
Pgf										V
Vegfc										V
Pdgfd										V
Dock1										V
Mapk9										V
Pak2										V
Rac3										V
Rac1										V
Actg1										V
+ 04520: Adherens junction	0.5	2.1	0.5	0.4	2.9	0.4	0.6	1.9	2.3	3.1
Mapk3	V					V				V
Ctnnb1	V				V					V
Cdh1		V							V
Ctnna1		V			V		V	V		V
Egfr		V							V
Baiap2		V								V
Nectin2		V							V
Met			V			V			V
Csnk2b				V				V	V
Smad4					V					V
Mapk1					V			V		V
Csnk2a1					V				V
Csnk2a2					V
Ptprj					V
Ptpn1					V					V
Was					V					V
Rac2					V					V
Actb					V					V
Sorbs1					V				V	V
Actn1					V					V
Actn4					V	V				V
Iqgap1					V			V		V
Fyn						V				V
Src							V	V
Ptpn6									V	V
Ptprf									V
Afdn									V
Nectin1									V
Nectin3									V
Pard3									V
Farp2									V
Tcf7l1										V
Tcf7l2										V
Fer										V
Snai1										V
Tgfbr2										V
Fgfr1										V
Erbb2										V
Igf1r										V
Ptprm										V
Acp1										V
Rhoa										V
Wasf2										V
Wasf1										V
Rac3										V
Rac1										V
Cdc42										V
Actg1										V
Vcl										V
+ 04530: Tight junction	0.8	2.2	0.4	1	2.8	1.8	3.6	2.3	3	4.3
Ppp2r1b	V					V				V
Mapk8	V
Prkag2	V					V				V
Jun	V									V
Dlg1	V						V
Myh14	V
Cgn		V							V
Epb41l4b		V							V
Igsf5		V							V
Marveld2		V							V
Cldn1		V				V			V
Tuba4a		V				V			V
Tuba8		V							V
Nf2		V			V		V	V	V
Ccnd1		V			V				V
Dlg3			V
Nedd4			V
Tuba1b				V						V
Arhgef2				V	V					V
Cttn				V		V			V	V
Myl6				V			V			V
Arhgap17					V					V
Magi1					V				V
Actn1					V					V
Actn4					V	V				V
Actb					V					V
Micall2					V
Cacna1d					V					V
Msn					V					V
Prkab1					V	V			V	V
Tjp2					V				V	V
Tuba1c					V					V
Was					V					V
Actr2					V
Actr3					V
Pcna					V			V		V
Runx1					V			V		V
Cd1d1					V	V	V			V
Hcls1					V					V
Rab8b					V			V		V
Itgb1					V					V
Myh9					V
Myh15					V			V
Cgnl1					V			V	V	V
Tjap1					V					V
Pard6b						V
Pard6g						V	V			V
Stk11						V				V
Cldn24						V				V
Cldn10						V				V
Cldn22						V				V
Amotl2						V	V	V		V
Myh10						V	V			V
Myl2							V
Src							V	V
Mpdz							V			V
Cldn5							V			V
Prkab2							V			V
Prkag3							V
Rap1a								V		V
Cldn23								V
Patj									V	V
Ocln									V
Pard3									V
Prkcz									V	V
Map2k7									V	V
Slc9a3r1									V
Rdx									V
Llgl1									V	V
Cldn3									V
Cldn14									V
Prkaa2									V
Afdn									V
Amotl1									V
Gata4									V
Rab8a									V
Crb3									V
Tjp3									V
Pard6a										V
Cdc42										V
Tiam1										V
Rhoa										V
Rock1										V
Prkci										V
Rac1										V
Ppp2ca										V
Ppp2cb										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r2a										V
Ppp2r2b										V
Actg1										V
Rab13										V
Prkaca										V
Vasp										V
Mapk9										V
Ybx3										V
Ezr										V
Cldn11										V
Cldn15										V
Prkaa1										V
Prkag1										V
Tuba1a										V
Whamm										V
Actr3b										V
Cdk4										V
Erbb2										V
Jam2										V
Jam3										V
Scrib										V
Myh11										V
Myl12b										V
Myl9										V
Prkce										V
+ 04540: Gap junction	0.7	2.3	0	1.9	1.5	1	0.5	2.1	0.2	2.4
Adcy6	V					V				V
Mapk3	V					V				V
Grb2	V	V			V					V
Tubb5		V			V			V		V
Tubb4b		V		V
Tuba4a		V				V			V
Tuba8		V							V
Egfr		V							V
Tubb2a				V
Tuba1b				V						V
Itpr1				V						V
Htr2b					V
Cdk1					V
Tubb6					V			V		V
Tubb2b					V			V		V
Adcy3					V					V
Adcy7					V
Tuba1c					V					V
Mapk1					V			V		V
Pdgfa					V					V
Pdgfc					V					V
Gnai1						V	V			V
Gucy1a1						V				V
Raf1						V		V		V
Gnas						V				V
Src							V	V
Adcy9									V
Kras									V
Sos1									V
Gnaq									V
Csnk1d										V
Prkcb										V
Gnai2										V
Gja1										V
Mapk7										V
Map2k5										V
Lpar1										V
Prkaca										V
Tubb3										V
Tubb4a										V
Adcy4										V
Adcy5										V
Tuba1a										V
Gucy1b1										V
Map2k1										V
Pdgfd										V
Adrb1										V
Gna11										V
Itpr3										V
+ 04550: Signaling pathways regulating pluripotency of stem cells	2.3	2.2	2	0.4	1.4	1.7	0	0.3	0.6	2.3
Fzd4	V		V							V
Fzd8	V
Ctnnb1	V				V					V
Gsk3b	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Grb2	V	V			V					V
Acvr1	V									V
Mapk3	V					V				V
Lifr		V	V						V
Stat3		V			V			V
Inhba		V
Igf1		V	V						V
Smad9		V				V			V
Id3		V				V				V
Onecut1		V							V
Smad5			V			V				V
Mapk14			V	V	V				V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Dvl1					V					V
Pik3cd					V
Akt1					V					V
Smad2					V					V
Mapk1					V			V		V
Smad1					V				V
Mapk12					V					V
Smad4					V					V
Jarid2					V					V
Dusp9					V					V
Wnt2b						V				V
Pik3r2						V				V
Acvr1c						V				V
Bmp4						V				V
Raf1						V		V		V
Meis1						V				V
Isl1						V				V
Wnt2									V
Wnt5b									V	V
Inhbc									V
Inhbe									V
Kras									V
Fgfr3									V
Fgfr4									V
Id2									V
Setdb1									V
Wnt9a										V
Wnt6										V
Axin2										V
Dvl2										V
Fzd1										V
Fzd6										V
Fzd2										V
Klf4										V
Pik3r3										V
Akt2										V
Akt3										V
Tbx3										V
Inhbb										V
Bmpr1a										V
Bmpr2										V
Map2k1										V
Fgf2										V
Fgfr1										V
Igf1r										V
Mapk11										V
Myc										V
Lefty1										V
Rest										V
Bmi1										V
Pcgf5										V
+ 4.5 Cell motility	1	0.3	0.2	0.4	6.2	0.7	1.3	3.8	0.2	5
+ 04810: Regulation of actin cytoskeleton	1	0.3	0.2	0.4	6.2	0.7	1.3	3.8	0.2	5
Diaph1	V									V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Itga3	V					V	V			V
Fgf21	V			V	V
Myh14	V
Kng1	V								V
Cyfip1		V			V					V
Baiap2		V								V
Itga5		V			V					V
Egfr		V							V
Fgf1			V						V
Cxcl12			V		V				V	V
Cfl1				V	V					V
Tmsb4x					V			V		V
Arpc1b					V			V		V
Arpc5					V			V		V
Arpc4					V					V
Arpc2					V				V	V
Pfn1					V					V
Nckap1l					V			V		V
Cyfip2					V			V		V
Limk1					V			V		V
Gsn					V	V	V			V
Pip4k2b					V
Pip5k1c					V				V
Pip4k2a					V			V		V
Actn1					V					V
Actn4					V	V				V
Msn					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Diaph3					V
Rac2					V					V
Arhgef1					V					V
Iqgap1					V			V		V
Iqgap2					V				V
Vav1					V			V
Vav3					V					V
Mapk1					V			V		V
Pik3cd					V
Fgd3					V
Itga4					V			V		V
Itga6					V					V
Itga7					V					V
Itgam					V					V
Itgax					V			V		V
Itgb1					V					V
Itgb2					V			V
Itgb4					V					V
Fn1					V	V	V	V	V
Gna12					V
Gna13					V					V
Pdgfa					V					V
Pdgfc					V					V
F2r					V				V
Actb					V					V
Myh9					V
Cxcr4					V			V		V
Lpar5					V
Braf						V
Raf1						V		V		V
Pik3r2						V				V
Ptk2						V	V			V
Rras						V				V
Fgf10						V				V
Myh10						V	V			V
Myl2							V
Src							V	V
Itgb5							V			V
F2									V
Ssh3									V	V
Rdx									V
Arhgap35									V
Itgb2l									V
Kras									V
Sos1									V
Fgfr3									V
Fgfr4									V
Kng2									V
Arpc3										V
Arpc1a										V
Pfn2										V
Wasf2										V
Wasf1										V
Brk1										V
Ssh1										V
Cfl2										V
Limk2										V
Vcl										V
Pip4k2c										V
Pip5k1b										V
Ezr										V
Ppp1r12a										V
Ppp1ca										V
Ppp1r12c										V
Ppp1r12b										V
Myl12b										V
Myl9										V
Mylk										V
Rock1										V
Pak2										V
Arhgef7										V
Cdc42										V
Rac3										V
Rac1										V
Rhoa										V
Tiam1										V
Map2k1										V
Araf										V
Pik3r3										V
Dock1										V
Fgd1										V
Gng12										V
Itgae										V
Itgb7										V
Itga11										V
Mras										V
Rras2										V
Fgfr1										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Pdgfd										V
Actg1										V
Lpar1										V
Lpar4										V
+ 5. Organismal Systems	11.3	4.8	6.7	9.7	16	12.3	8	10.1	8.5	22.3
+ 5.1 Immune system	6.7	3.2	3.1	5	17.7	2.8	2.2	12.9	4.6	15.1
+ 04640: Hematopoietic cell lineage	0.6	0.4	0.3	0.7	4.7	0.2	1.2	2.4	0.1	2.8
Itga3	V					V	V			V
Cd59a	V				V					V
Cd36	V				V					V
Itga5		V			V					V
Cd9		V		V	V			V		V
Kit			V
Flt3l				V						V
Itga4					V			V		V
Itga6					V					V
Cd44					V			V
Itgam					V					V
Anpep					V			V	V
Csf1r					V
Fcgr1					V			V		V
Il4ra					V					V
Csf2ra					V					V
Il3ra					V					V
Cd37					V					V
Cd22					V
Mme					V				V	V
Cd1d1					V	V	V			V
Il7r					V			V		V
H2-Aa					V					V
H2-Ab1					V					V
H2-Eb1					V					V
H2-DMb1					V					V
Tnf					V
Csf1					V					V
Cd59b						V				V
Cd33						V	V
Cd34							V			V
Cd14								V		V
Il6ra									V
Tfrc									V
Thpo									V
Il1a									V
Il1b									V
Gm2002										V
Gm13305										V
Il11ra2										V
Il11ra1										V
Cd55										V
Epor										V
Il1r1										V
Cd24a										V
Cd3g										V
Cd2										V
Cd7										V
Cd38										V
Il2ra										V
H2-DMb2										V
Il4										V
Il7										V
+ 04610: Complement and coagulation cascades	0.6	2.1	1.4	0.3	2.9	1.8	0.1	2	9.1	0.2
Kng1	V								V
Cd59a	V				V					V
Cfd	V			V		V	V			V
Fgb		V							V
Fga		V							V
Fgg		V							V
C1rb		V	V
C8a		V							V
Serpina1e		V							V
F5			V						V
F8			V
F10					V				V
F7					V				V
F13a1					V					V
Tfpi					V	V				V
F2r					V				V
Serpine1					V			V		V
Plau					V					V
C1qb					V					V
C1qc					V					V
Pros1					V
Clu					V	V			V
Plaur					V			V		V
Itgam					V					V
Itgb2					V			V
Itgax					V			V		V
C5ar1					V			V		V
C3ar1					V			V		V
Masp1						V			V
C1ra						V
C6						V			V
Cd59b						V				V
Thbd						V				V
C2						V				V
F3						V				V
F12									V
F11									V
F9									V
F13b									V
Serpind1									V
Serpinc1									V
Plg									V
Kng2									V
Klkb1									V
Mbl1									V
Mbl2									V
Masp2									V
C1s2									V
C1s1									V
C3									V	V
Cfh									V
C8b									V
C9									V
C8g									V
Proc									V
Serpina1a									V
Serpina1d									V
Serpina1b									V
Serpina1c									V
F2									V
Serpinf2									V
Cfi									V
Cpb2									V
Vtn									V
Itgb2l									V
Vsig4									V
Cfhr1									V
Plat										V
C1qa										V
C7										V
Cd46										V
Cd55										V
Procr										V
+ 04611: Platelet activation	1.8	0.5	1.1	1.9	5.1	1.4	0.2	3	0.3	4.7
P2ry1	V				V
Rasgrp2	V		V			V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Adcy6	V					V				V
Col3a1	V			V	V					V
Fgb		V							V
Fga		V							V
Fgg		V							V
Mapk14			V	V	V				V
Stim1			V			V			V	V
Itpr1				V						V
Vamp8				V
F2r					V				V
Itgb1					V					V
Plcg2					V			V		V
Rap1b					V					V
Apbb1ip					V			V		V
Tln1					V					V
Pik3cd					V
Akt1					V					V
Mapk12					V					V
Mapk1					V			V		V
Gna13					V					V
Arhgef1					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Adcy3					V					V
Adcy7					V
Pik3cg					V					V
Pik3r5					V			V		V
Ptgir					V					V
Tbxas1					V					V
Actb					V					V
Col1a1					V					V
Fermt3					V
Fcer1g					V			V		V
Lyn					V
Lcp2					V			V
Btk					V			V		V
Syk					V			V		V
Pik3r2						V				V
Gucy1a1						V				V
Gnai1						V	V			V
Gnas						V				V
Fyn						V				V
Src							V	V
Rap1a								V		V
Gnaq									V
Adcy9									V
Prkcz									V	V
Arhgap35									V
F2									V
Itpr3										V
Orai1										V
Pik3r3										V
Akt2										V
Akt3										V
Nos3										V
Gucy1b1										V
Mapk11										V
Rhoa										V
Rock1										V
Ppp1r12a										V
Ppp1ca										V
Myl12b										V
Mylk										V
P2ry12										V
Gnai2										V
Adcy4										V
Adcy5										V
Pla2g4a										V
Ptgs1										V
Prkaca										V
Vasp										V
Actg1										V
Col1a2										V
Prkci										V
+ 04620: Toll-like receptor signaling pathway	2.9	0.3	1.9	2.7	5.2	0.3	0	3	1	2.7
Mapk3	V					V				V
Mapk8	V
Stat1	V				V				V	V
Ikbkg	V				V				V	V
Cxcl9	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Map2k6	V		V		V
Jun	V									V
Irf5		V			V
Rela		V						V	V
Mapk14			V	V	V				V
Tlr3			V
Map2k3			V
Irak1				V				V		V
Irf7				V
Nfkbia				V				V		V
Lbp				V	V					V
Mapk1					V			V		V
Map3k8					V					V
Spp1					V				V
Ripk1					V
Cxcl10					V	V		V		V
Mapk12					V					V
Ikbke					V				V
Akt1					V					V
Tnf					V
Ly96					V
Tlr6					V			V
Tlr9					V					V
Ticam2					V					V
Casp8					V					V
Ccl3					V			V
Pik3cd					V
Ifnar2					V					V
Tlr7					V
Tlr8					V
Fos					V					V
Ccl4					V			V
Ctsk					V					V
Pik3r2						V				V
Cd14								V		V
Irak4									V
Tirap									V
Il1b									V
Tbk1									V
Irf3									V
Ifnar1									V	V
Map2k7									V	V
Chuk										V
Nfkb1										V
Cd86										V
Cd40										V
Ikbkb										V
Mapk11										V
Rac1										V
Mapk9										V
Fadd										V
Ccl5										V
Tab1										V
Akt2										V
Akt3										V
Tab2										V
Tlr4										V
Pik3r3										V
Map2k4										V
Map2k1										V
+ 04621: NOD-like receptor signaling pathway	1.3	0.5	0.2	1.1	3.3	0	0.7	3.5	0.3	1.1
Il18	V					V				V
Mapk8	V
Mapk3	V					V				V
Jun	V									V
Ikbkg	V				V				V	V
Stat1	V				V				V	V
Vdac1	V									V
Txnip	V	V								V
Mfn2	V									V
Hsp90aa1		V					V		V
Rela		V						V	V
Nlrp12		V							V
Nek7		V					V
Mapk14			V	V	V				V
Erbin			V		V		V	V
Irf7				V
Itpr1				V						V
Nfkbia				V				V		V
Ywhae				V						V
Pycard					V					V
Casp1					V			V		V
Nlrp1a					V
Nlrc4					V			V
Mapk1					V			V		V
Mapk12					V					V
Pstpip1					V	V				V
Naip2					V
P2rx7					V			V
Trpv2					V					V
Panx1					V
Ikbke					V				V
Casp4					V					V
Ifnar2					V					V
Atg12					V					V
Tank					V			V		V
Cybb					V			V		V
Cyba					V					V
Sting1					V					V
Prkcd					V			V		V
Casp8					V					V
Dhx33					V				V
Ripk1					V
Ripk3					V					V
Dnm1l					V					V
Ctsb					V			V		V
Tnf					V
Cxcl2					V
Ccl2					V			V		V
Pkn2					V
Pkn1					V					V
Sharpin						V	V		V
Rbck1						V
Nampt						V				V
Tab3							V
Nlrx1							V			V
Ifi204								V		V
Ifi207								V		V
Tnfaip3								V
Bcl2l1								V
Il1b									V
Hsp90ab1									V	V
Tbk1									V
Irf3									V
Irak4									V
Tyk2									V
Stat2									V
Ifnar1									V	V
Xiap									V
Txn2									V
Nlrp6									V
Chuk										V
Ikbkb										V
Tab1										V
Tab2										V
Sugt1										V
Mapk9										V
Mapk11										V
Aim2										V
Nfkb1										V
Itpr3										V
Tlr4										V
Antxr1										V
Antxr2										V
Gbp2										V
Gbp5										V
Rhoa										V
Mavs										V
Vdac2										V
Vdac3										V
Casp12										V
Nfkbib										V
Birc3										V
Atg16l1										V
Gabarap										V
Gabarapl2										V
Trip6										V
Traf2										V
Fadd										V
Bcl2										V
Rnasel										V
Ccl12										V
Ccl5										V
+ 04622: RIG-I-like receptor signaling pathway	0.9	1.1	1.1	1.6	1.8	0.2	0.6	1.5	0.9	0.9
Rnf125	V								V
Ikbkg	V				V				V	V
Mapk8	V
Rela		V						V	V
Tkfc		V				V			V
Ddx3x		V
Azi2			V							V
Mapk14			V	V	V				V
Irf7				V
Nfkbia				V				V		V
Ikbke					V				V
Tank					V			V		V
Casp8					V					V
Atg12					V					V
Sting1					V					V
Ripk1					V
Mapk12					V					V
Tnf					V
Cxcl10					V	V		V		V
Otud5						V	V			V
Nlrx1							V			V
Ifih1									V
Irf3									V
Tbk1									V
Mavs										V
Nfkb1										V
Tbkbp1										V
Fadd										V
Chuk										V
Ikbkb										V
Nfkbib										V
Pin1										V
Sike1										V
Mapk9										V
Mapk11										V
Traf2										V
+ 04623: Cytosolic DNA-sensing pathway	0.6	0.7	0.5	1.1	1.7	0.1	0	2.1	1.1	1.8
Il18	V					V				V
Ikbkg	V				V				V	V
Rela		V						V	V
Polr1d		V	V							V
Irf7				V
Nfkbia				V				V		V
Casp1					V			V		V
Pycard					V					V
Ikbke					V				V
Cxcl10					V	V		V		V
Sting1					V					V
Ripk1					V
Ripk3					V					V
Polr3g					V				V
Ccl4					V			V
Il1b									V
Zbp1									V
Tbk1									V
Irf3									V
Polr2h									V
Aim2										V
Mavs										V
Nfkb1										V
Chuk										V
Ikbkb										V
Il33										V
Nfkbib										V
Polr3e										V
Polr2e										V
Polr2l										V
Polr3k										V
Polr2f										V
Polr3gl										V
Polr3h										V
Ccl5										V
Trex1										V
+ 04625: C-type lectin receptor signaling pathway	2.3	0.6	0.3	1.6	5.3	0.6	1	4	0.4	5.9
Ikbkg	V				V				V	V
Stat1	V				V				V	V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mdm2	V	V			V					V
Mapk8	V
Jun	V									V
Rela		V						V	V
Bcl3		V			V				V
Mapk14			V	V	V				V
Nfkbia				V				V		V
Itpr1				V						V
Clec4b1					V					V
Clec4d					V					V
Fcer1g					V			V		V
Syk					V			V		V
Casp1					V			V		V
Pycard					V					V
Casp8					V					V
Ikbke					V				V
Il10					V
Prkcd					V			V		V
Plcg2					V			V		V
Mapk1					V			V		V
Nfatc1					V					V
Tnf					V
Pik3cd					V
Akt1					V					V
Nfkb2					V					V
Relb					V	V	V	V		V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Ccl22					V					V
Egr2					V					V
Egr3					V
Mapk12					V					V
Raf1						V		V		V
Rras						V				V
Pik3r2						V				V
Cd209b							V			V
Src							V	V
Ppp3ca							V			V
Cd209g								V		V
Plk3									V
Kras									V
Il1b									V
Stat2									V
Clec1b									V
Cd209c										V
Cd209d										V
Cd209a										V
Lsp1										V
Ksr1										V
Nfkb1										V
Mras										V
Rras2										V
Ptpn11										V
Chuk										V
Ikbkb										V
Rhoa										V
Il17d										V
Mapkapk2										V
Bcl10										V
Nfatc4										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Itpr3										V
Map3k14										V
Cblb										V
Pik3r3										V
Akt2										V
Akt3										V
Calml4										V
Mapk11										V
Mapk9										V
+ 04650: Natural killer cell mediated cytotoxicity	1.8	0.5	0.2	0.2	3.6	0.7	0.1	3.1	0.3	1.7
Bid	V
Fas	V				V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Grb2	V	V			V					V
Raet1d	V								V
Icam1		V			V
Raet1e		V							V
Sh3bp2			V		V			V	V
Nfatc1					V					V
Plcg2					V			V		V
Tnf					V
Lcp2					V			V
Syk					V			V		V
Sh2d1b1					V
Fcer1g					V			V		V
Tyrobp					V					V
Cd48					V					V
Ulbp1					V
Pik3cd					V
Mapk1					V			V		V
Shc2					V					V
Rac2					V					V
Vav1					V			V
Vav3					V					V
Ifnar2					V					V
Fcgr4					V				V
Itgb2					V			V
H2-K1					V				V	V
Fyn						V				V
Ifngr1						V				V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Ppp3ca							V			V
H2-D1								V		V
Ptpn6									V	V
Kras									V
Sos1									V
Ifnar1									V	V
Itgb2l									V
H2-T23									V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Tnfsf10										V
Ifngr2										V
Plcg1										V
Lat										V
Prkcb										V
Ptk2b										V
Cd247										V
Ptpn11										V
Tnfrsf10b										V
Icam2										V
Pik3r3										V
Map2k1										V
Araf										V
Rac3										V
Rac1										V
+ 04612: Antigen processing and presentation	0.4	1.9	0	2	3.4	0.1	0.1	2.6	1.3	1.6
Tap1	V									V
Tap2	V	V								V
Calr		V		V	V				V
Pdia3		V							V
Hspa5		V		V					V
Hsp90aa1		V					V		V
Psme2				V		V				V
Psme2b				V		V				V
Cd74					V					V
H2-DMb1					V					V
Nfya					V			V		V
Rfx5					V					V
Ctsb					V			V		V
Ctsl					V			V	V
Ctss					V					V
Lgmn					V			V		V
Ifi30					V			V		V
H2-K1					V				V	V
H2-M2					V
H2-Q4					V					V
H2-Aa					V					V
H2-Ab1					V					V
H2-Eb1					V					V
Hspa8					V			V	V	V
Tnf					V
H2-Q10						V			V
H2-D1								V		V
H2-Q7									V
H2-T23									V
Canx									V
Hsp90ab1									V	V
H2-DMb2										V
Nfyb										V
Nfyc										V
Rfxank										V
Ciita										V
Tapbp										V
H2-M3										V
H2-T22										V
Hspa2										V
Hspa1a										V
Psme1										V
+ 04660: T cell receptor signaling pathway	2.9	0.3	0.3	1.2	2.4	0.5	0.3	1.8	0.1	3.8
Ikbkg	V				V				V	V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Jun	V									V
Mapk3	V					V				V
Mapk8	V
Dlg1	V						V
Gsk3b	V									V
Rela		V						V	V
Mapk14			V	V	V				V
Nfkbia				V				V		V
Tnf					V
Il10					V
Nfkbie					V
Map3k8					V					V
Akt1					V					V
Pik3cd					V
Fos					V					V
Nfatc1					V					V
Vav1					V			V
Vav3					V					V
Lcp2					V			V
Ptprc					V					V
Mapk1					V			V		V
Mapk12					V					V
Pik3r2						V				V
Fyn						V				V
Raf1						V		V		V
Ppp3ca							V			V
Sos1									V
Kras									V
Ptpn6									V	V
Map2k7									V	V
Cdk4										V
Il4										V
Nfkbib										V
Nfkb1										V
Ikbkb										V
Chuk										V
Map3k14										V
Akt2										V
Akt3										V
Bcl10										V
Pik3r3										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Plcg1										V
Lat										V
Rhoa										V
Cdc42										V
Pak2										V
Nck1										V
Nck2										V
Cd247										V
Cd3g										V
Cblb										V
Map2k1										V
Mapk9										V
Mapk11										V
+ 04658: Th1 and Th2 cell differentiation	1.6	0.1	0.4	0.8	3	0	0.9	1.2	0.2	4
Ikbkg	V				V				V	V
Mapk3	V					V				V
Mapk8	V
Jun	V									V
Stat1	V				V				V	V
Rela		V						V	V
Mapk14			V	V	V				V
Nfkbia				V				V		V
Nfkbie					V
Nfatc1					V					V
Mapk1					V			V		V
Mapk12					V					V
Fos					V					V
Il4ra					V					V
Stat6					V					V
Il2rg					V					V
Stat5b					V
Notch2					V			V	V
H2-Aa					V					V
H2-Ab1					V					V
H2-Eb1					V					V
H2-DMb1					V					V
Ifngr1						V				V
Ppp3ca							V			V
Stat5a							V			V
Dll1							V
Il12rb1									V
Tyk2									V
Nfkbib										V
Nfkb1										V
Chuk										V
Ikbkb										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Cd247										V
Cd3g										V
Mapk11										V
Mapk9										V
Lat										V
Plcg1										V
Ifngr2										V
Il4										V
Il2ra										V
Il2rb										V
Maf										V
Jag1										V
Jag2										V
Notch1										V
Dll4										V
Notch3										V
H2-DMb2										V
+ 04659: Th17 cell differentiation	1.3	0.7	0.8	1.2	4.2	0.1	1.1	2.2	1.7	4.7
Ikbkg	V				V				V	V
Mapk3	V					V				V
Mapk8	V
Jun	V									V
Stat1	V				V				V	V
Rela		V						V	V
Stat3		V			V			V
Hsp90aa1		V					V		V
Mapk14			V	V	V				V
Rxra			V	V					V
Nfkbia				V				V		V
Nfkbie					V
Nfatc1					V					V
Mapk1					V			V		V
Mapk12					V					V
Fos					V					V
Il2rg					V					V
Il4ra					V					V
Stat6					V					V
Stat5b					V
H2-Aa					V					V
H2-Ab1					V					V
H2-Eb1					V					V
H2-DMb1					V					V
Runx1					V			V		V
Rara					V			V	V
Tgfb1					V					V
Smad2					V					V
Smad4					V					V
Il27ra					V					V
Hif1a					V			V	V
Ifngr1						V				V
Rorc						V				V
Ppp3ca							V			V
Stat5a							V			V
Mtor							V			V
Il1rap									V
Il6ra									V
Il12rb1									V
Rxrb									V	V
Il1b									V
Hsp90ab1									V	V
Ahr									V
Tyk2									V
Nfkbib										V
Nfkb1										V
Chuk										V
Ikbkb										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Mapk11										V
Mapk9										V
Lat										V
Plcg1										V
Ifngr2										V
Il4										V
Il2ra										V
Il2rb										V
H2-DMb2										V
Il1r1										V
Il21r										V
Tgfbr2										V
Rora										V
Irf4										V
Rxrg										V
Il17d										V
Cd3g										V
Cd247										V
+ 04657: IL-17 signaling pathway	1.4	0.8	0.9	1.8	2.7	0.4	0.8	2.8	1	1.9
Ikbkg	V				V				V	V
Jun	V									V
Mapk3	V					V				V
Mapk8	V
Gsk3b	V									V
Rela		V						V	V
Hsp90aa1		V					V		V
Hsp90b1		V							V
Mapk14			V	V	V				V
Mapk6			V	V	V					V
Nfkbia				V				V		V
Lcn2				V
Fos					V					V
Fosl1					V			V
Ikbke					V				V
Mapk1					V			V		V
Mapk12					V					V
Casp8					V					V
Cxcl2					V
Ccl2					V			V		V
Ccl7					V			V		V
Mmp13					V
Mmp3					V					V
Tnf					V
Cxcl10					V	V		V		V
S100a8					V
Il17rb						V
Srsf1						V			V	V
Mmp9						V				V
Tab3							V
Il17re							V			V
Tnfaip3								V
Hsp90ab1									V	V
Cebpb									V
Tbk1									V
Traf4									V
Il1b									V
Ikbkb										V
Chuk										V
Tab2										V
Nfkb1										V
Jund										V
Traf3ip2										V
Traf2										V
Elavl1										V
Mapk11										V
Mapk4										V
Mapk7										V
Mapk9										V
Fadd										V
Il17d										V
Ccl12										V
Il4										V
Anapc5										V
Ccl11										V
+ 04662: B cell receptor signaling pathway	3	1.5	0	0.9	4.4	0.6	0.5	4.4	1.2	5.1
Ikbkg	V				V				V	V
Gsk3b	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Jun	V									V
Blnk	V				V			V		V
Mapk3	V					V				V
Grb2	V	V			V					V
Rela		V						V	V
Fcgr2b		V			V				V	V
Pik3ap1		V			V			V	V
Nfkbia				V				V		V
Nfkbie					V
Akt1					V					V
Vav1					V			V
Vav3					V					V
Pik3cd					V
Inpp5d					V			V		V
Fos					V					V
Nfatc1					V					V
Rac2					V					V
Plcg2					V			V		V
Btk					V			V		V
Lyn					V
Syk					V			V		V
Cd72					V
Cd22					V
Mapk1					V			V		V
Pik3r2						V				V
Raf1						V		V		V
Cd81							V		V	V
Ppp3ca							V			V
Inppl1									V	V
Kras									V
Rasgrp3									V
Ptpn6									V	V
Lilra5									V
Sos1									V
Nfkbib										V
Nfkb1										V
Ikbkb										V
Chuk										V
Bcl10										V
Akt2										V
Akt3										V
Prkcb										V
Pik3r3										V
Ifitm1										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Rac3										V
Rac1										V
Cd79b										V
Cd79a										V
Map2k1										V
Dapp1										V
+ 04664: Fc epsilon RI signaling pathway	2.4	0.2	1.8	1	4.4	1.5	0	3.9	0.1	3.6
Map2k6	V		V		V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Grb2	V	V			V					V
Mapk8	V
Mapk14			V	V	V				V
Map2k3			V
Fcer1g					V			V		V
Tnf					V
Akt1					V					V
Mapk12					V					V
Pik3cd					V
Gab2					V					V
Lcp2					V			V
Btk					V			V		V
Syk					V			V		V
Lyn					V
Plcg2					V			V		V
Inpp5d					V			V		V
Mapk1					V			V		V
Rac2					V					V
Vav1					V			V
Vav3					V					V
Fyn						V				V
Pik3r2						V				V
Raf1						V		V		V
Alox5						V				V
Map2k7									V	V
Kras									V
Sos1									V
Fcer1a										V
Il4										V
Akt2										V
Akt3										V
Mapk11										V
Map2k4										V
Pik3r3										V
Lat										V
Plcg1										V
Map2k1										V
Pla2g4a										V
Mapk9										V
Rac3										V
Rac1										V
+ 04666: Fc gamma R-mediated phagocytosis	1.1	0.4	0	1.3	6.7	0.9	0.4	4.8	0.3	6.9
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Pla2g6	V			V	V	V	V			V
Fcgr2b		V			V				V	V
Asap2		V
Cfl1				V	V					V
Fcgr4					V				V
Fcgr1					V			V		V
Hck					V			V
Lyn					V
Syk					V			V		V
Ptprc					V					V
Pik3cd					V
Inpp5d					V			V		V
Plcg2					V			V		V
Prkcd					V			V		V
Mapk1					V			V		V
Akt1					V					V
Vav1					V			V
Vav3					V					V
Rac2					V					V
Arpc1b					V			V		V
Arpc5					V			V		V
Arpc4					V					V
Arpc2					V				V	V
Was					V					V
Dock2					V			V		V
Limk1					V			V		V
Asap3					V
Marcks					V					V
Gsn					V	V	V			V
Pip5k1c					V				V
Gab2					V					V
Arf6					V
Ncf1					V					V
Pik3r2						V				V
Raf1						V		V		V
Inppl1									V	V
Rps6kb1									V
Myo10									V
Sphk2									V	V
Pik3r3										V
Lat										V
Plcg1										V
Prkce										V
Map2k1										V
Pla2g4a										V
Akt2										V
Akt3										V
Rps6kb2										V
Rac1										V
Wasf2										V
Wasf1										V
Arpc3										V
Arpc1a										V
Cdc42										V
Pld2										V
Vasp										V
Limk2										V
Cfl2										V
Asap1										V
Marcksl1										V
Pip5k1b										V
Plpp1										V
Plpp3										V
Dnm2										V
Amph										V
Sphk1										V
Prkcb										V
+ 04670: Leukocyte transendothelial migration	0.4	0.9	0.7	0.6	5.7	1.8	1.3	3.1	0.8	5.4
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ctnnb1	V				V					V
Cldn1		V				V			V
Ctnna1		V			V		V	V		V
Rapgef4		V							V	V
Icam1		V			V
Mapk14			V	V	V				V
Cxcl12			V		V				V	V
Mmp2					V					V
Cdh5					V				V	V
Itgb2					V			V
Sipa1					V					V
Itgb1					V					V
Itga4					V			V		V
Itgam					V					V
Pik3cd					V
Actb					V					V
Mapk12					V					V
Cybb					V			V		V
Cyba					V					V
Ncf2					V					V
Ncf1					V					V
Ncf4					V					V
Rap1b					V					V
Vav1					V			V
Vav3					V					V
Rac2					V					V
Msn					V					V
Rassf5					V				V
Cxcr4					V			V		V
Thy1					V					V
Vcam1					V					V
Plcg2					V			V		V
Rhoh					V					V
Actn1					V					V
Actn4					V	V				V
Cldn24						V				V
Cldn10						V				V
Cldn22						V				V
Mmp9						V				V
Pik3r2						V				V
Ptk2						V	V			V
Rapgef3						V		V		V
Gnai1						V	V			V
Cldn5							V			V
Myl2							V
Cldn23								V
Rap1a								V		V
Cldn3									V
Ocln									V
Cldn14									V
Pecam1									V	V
Itgb2l									V
Afdn									V
Arhgap5									V
Arhgap35									V
Cldn11										V
Cldn15										V
Esam										V
Ptpn11										V
Jam2										V
Pik3r3										V
Actg1										V
Myl12b										V
Myl9										V
Rock1										V
Prkcb										V
Rhoa										V
Jam3										V
Mapk11										V
Rac1										V
Ezr										V
Ptk2b										V
Gnai2										V
Plcg1										V
Cdc42										V
Vcl										V
Vasp										V
+ 04672: Intestinal immune network for IgA production	0	0	0.8	0	2.8	0	0	1	0.2	2.3
Cxcl12			V		V				V	V
Tgfb1					V					V
Tnfrsf13b					V					V
H2-Aa					V					V
H2-Ab1					V					V
H2-Eb1					V					V
H2-DMb1					V					V
Il10					V
Itga4					V			V		V
Cxcr4					V			V		V
Il15ra									V	V
Pigr									V
Cd40										V
Cd86										V
H2-DMb2										V
Ccr10										V
Itgb7										V
Il4										V
Ccl25										V
Map3k14										V
Icosl										V
+ 04062: Chemokine signaling pathway	2.7	0.8	1	0.2	5.7	1.1	0.1	5.4	0	6.4
Cxcl9	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Grb2	V	V			V					V
Grk2	V				V					V
Grk6	V									V
Arrb1	V				V					V
Adcy6	V					V				V
Rasgrp2	V		V			V				V
Stat1	V				V				V	V
Mapk3	V					V				V
Ikbkg	V				V				V	V
Gsk3b	V									V
Ccl9		V			V					V
Cxcl13		V								V
Cxcl16		V	V					V
Stat3		V			V			V
Rela		V						V	V
Cxcl12			V		V				V	V
Gnb2			V							V
Nfkbia				V				V		V
Cxcr4					V			V		V
Ccr1					V			V		V
Cx3cr1					V
Cxcl10					V	V		V		V
Ccl2					V			V		V
Ccl22					V					V
Ccl3					V			V
Ccl4					V			V
Ccl6					V			V		V
Ccl7					V			V		V
Ccl8					V					V
Cxcl2					V
Cxcl14					V					V
Fgr					V
Hck					V			V
Lyn					V
Pik3cd					V
Shc2					V					V
Gng2					V					V
Elmo1					V					V
Grk5					V					V
Arrb2					V				V	V
Vav1					V			V
Vav3					V					V
Adcy3					V					V
Adcy7					V
Rap1b					V					V
Was					V					V
Prkcd					V			V		V
Ncf1					V					V
Stat5b					V
Mapk1					V			V		V
Akt1					V					V
Dock2					V			V		V
Rac2					V					V
Prex1					V			V
Pik3cg					V					V
Pik3r5					V			V		V
Ccl27a						V				V
Ccl24						V				V
Ptk2						V	V			V
Pik3r2						V				V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Braf						V
Raf1						V		V		V
Src							V	V
Rap1a								V		V
Adcy9									V
Pard3									V
Prkcz									V	V
Stat2									V
Kras									V
Sos1									V
Gsk3a									V
Cxcr3										V
Ccr2										V
Ccr10										V
Gm2023										V
Ccl19										V
LOC100041504										V
LOC100041593										V
Ccl21b										V
Gm10591										V
Gm13304										V
Ccl21d										V
Ccl21c										V
Gm1987										V
Ccl21a										V
Ccl11										V
Ccl12										V
Ccl25										V
Ccl5										V
Cx3cl1										V
Pf4										V
Rhoa										V
Pik3r3										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Grk3										V
Rock1										V
Cdc42										V
Adcy4										V
Adcy5										V
Prkcb										V
Tiam1										V
Prkaca										V
Ptk2b										V
Akt2										V
Akt3										V
Map2k1										V
Rac3										V
Rac1										V
Nfkb1										V
Chuk										V
Ikbkb										V
Nfkbib										V
Bad										V
+ 5.2 Endocrine system	8.9	3.3	3.4	8	7.4	7.6	5.8	3.9	5.4	12.7
+ 04911: Insulin secretion	0.7	0.1	0	1.9	0.3	0.3	0.1	0	0.3	1.4
Adcy6	V					V				V
Gck	V			V					V
Kcnn1	V
Rapgef4		V							V	V
Creb3l2				V
Atp1b1				V
Kcnn2				V					V
Cacna1d					V					V
Adcy3					V					V
Adcy7					V
Creb3					V					V
Atp1a1					V				V
Kcnn4					V					V
Cck					V					V
Gnas						V				V
Atp1a2						V				V
Vamp2						V				V
Fxyd2							V			V
Slc2a2									V
Adcy9									V
Gnaq									V
Creb3l3									V
Slc2a1										V
Cacna1c										V
Adcy4										V
Adcy5										V
Prkaca										V
Gna11										V
Prkcb										V
Atf4										V
Creb3l1										V
Camk2d										V
Camk2a										V
Camk2g										V
Trpm4										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Stx1a										V
Snap25										V
Itpr3										V
Rab3a										V
+ 04910: Insulin signaling pathway	4.8	1	0.2	2.6	1.5	5.4	3.3	1.2	1.9	6.2
Mapk8	V
Mapk3	V					V				V
Fasn	V			V		V				V
Prkag2	V					V				V
Pklr	V								V
Gys2	V								V
Acaca	V					V
Grb2	V	V			V					V
Fbp1	V								V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Gsk3b	V									V
Srebf1	V			V		V			V	V
Rapgef1	V	V							V
Gck	V			V					V
Slc2a4	V					V	V			V
Flot1	V									V
Socs2		V				V
Exoc7		V								V
Irs1		V				V
Phkg2			V	V	V	V				V
Acacb				V		V			V	V
Eif4e2				V		V
Ptpn1					V					V
Mknk1					V	V		V		V
Mapk1					V			V		V
Prkab1					V	V			V	V
Ppp1cc					V					V
Ppp1ccb					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Prkar2a					V				V
Shc2					V					V
Sorbs1					V				V	V
Akt1					V					V
Pik3cd					V
Hk3					V			V
Cbl					V
Lipe						V	V			V
Ppp1r3c						V
Gys1						V				V
Phkg1						V				V
Eif4ebp1						V	V			V
Pygb						V	V			V
Trip10						V		V		V
Braf						V
Raf1						V		V		V
Pck1						V	V
Pde3b						V	V			V
Pik3r2						V				V
Sh2b2						V				V
Prkab2							V			V
Prkag3							V
Phkb							V
Prkar2b							V			V
Mtor							V			V
Prkar1b								V		V
Inpp5k									V	V
Inppl1									V	V
Ptprf									V
Prkaa2									V
Ppp1r3b									V
Pygl									V
Sos1									V
Kras									V
Rps6kb1									V
G6pc									V
Ppargc1a									V
Prkcz									V	V
Ikbkb										V
Mapk9										V
Elk1										V
Mknk2										V
Prkaa1										V
Prkag1										V
Ppp1ca										V
Ppp1r3d										V
Ppp1r3f										V
Phka2										V
Calml4										V
Prkaca										V
Prkar1a										V
Rps6-ps4										V
Rps6										V
Pygm										V
Foxo1										V
Eif4e										V
Map2k1										V
Rps6kb2										V
Bad										V
Tsc2										V
Araf										V
Pck2										V
G6pc3										V
Rheb										V
Akt2										V
Akt3										V
Pik3r3										V
Hk1										V
Hk2										V
Prkci										V
Cblb										V
Irs3										V
Irs2										V
Flot2										V
+ 04922: Glucagon signaling pathway	2	0.1	0.8	2.6	0.6	3.6	2.8	0.1	2.1	3.8
Gck	V			V					V
Gys2	V								V
Cpt1a	V				V				V
Fbp1	V								V
Acaca	V					V
Prkag2	V					V				V
Sirt1	V		V	V
Gcgr		V							V
Phkg2			V	V	V	V				V
Creb3l2				V
Acacb				V		V			V	V
Itpr1				V						V
Creb3					V					V
Sik1					V
Akt1					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Prkab1					V	V			V	V
Ldha					V				V
Pdha1						V				V
Pdhb						V				V
Gnas						V				V
Gys1						V				V
Pygb						V	V			V
Crtc2						V				V
Sik2						V				V
Pck1						V	V
Pde3b						V	V			V
Phkg1						V				V
Pfkfb1						V
Ldhb						V	V			V
Phkb							V
Ppp3ca							V			V
Prkab2							V			V
Prkag3							V
Ppp4c								V		V
Slc2a2									V
Pygl									V
Gnaq									V
Creb3l3									V
Ppp4r3a									V
Ppargc1a									V
G6pc									V
Prmt1									V	V
Prkaa2									V
Ppara									V
Slc2a1										V
Pkm										V
Pfkl										V
Pfkm										V
Pfkp										V
Prkaca										V
Pygm										V
Atf4										V
Creb3l1										V
Pck2										V
G6pc3										V
Foxo1										V
Akt2										V
Akt3										V
Cpt1c										V
Phka2										V
Calml4										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Prkaa1										V
Prkag1										V
Camk2d										V
Camk2a										V
Camk2g										V
Itpr3										V
+ 04923: Regulation of lipolysis in adipocytes	1.7	0.8	0	0.5	0.5	4.5	3	0.2	0	4.2
Adcy6	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Fabp4	V					V	V			V
Irs1		V				V
Adora1		V
Adcy3					V					V
Adcy7					V
Mgll					V					V
Pik3cd					V
Akt1					V					V
Gnas						V				V
Adrb3						V				V
Lipe						V	V			V
Plin1						V				V
Pnpla2						V	V			V
Abhd5						V		V		V
Gnai1						V	V			V
Pde3b						V	V			V
Pik3r2						V				V
Plaat3							V			V
Adcy9									V
Adcy4										V
Adcy5										V
Prkaca										V
Adrb1										V
Adrb2										V
Aqp7										V
Gnai2										V
Pik3r3										V
Irs3										V
Irs2										V
Ptgs1										V
Tshr										V
Npy1r										V
Akt2										V
Akt3										V
+ 04920: Adipocytokine signaling pathway	2.3	2.1	1.1	2.1	2	1.7	2.6	0.9	2.8	3.7
Cpt1a	V				V				V
Prkag2	V					V				V
Slc2a4	V					V	V			V
Ikbkg	V				V				V	V
Mapk8	V
Cd36	V				V					V
Rela		V						V	V
Acsl4		V							V
Lepr		V							V
Stat3		V			V			V
Irs1		V				V
Acsl1			V		V				V	V
Rxra			V	V					V
Nfkbia				V				V		V
Acsl3				V					V
Acacb				V		V			V	V
Nfkbie					V
Acsl5					V					V
Lep					V					V
Prkab1					V	V			V	V
Tnfrsf1b					V
Akt1					V					V
Tnf					V
Pck1						V	V
Adipoq						V	V			V
Stk11						V				V
Prkab2							V			V
Prkag3							V
Mtor							V			V
G6pc									V
Prkaa2									V
Ppara									V
Camkk2									V
Rxrb									V	V
Ppargc1a									V
Nfkb1										V
Nfkbib										V
Ptpn11										V
Cpt1c										V
G6pc3										V
Pck2										V
Acsbg1										V
Prkaa1										V
Prkag1										V
Adipor1										V
Rxrg										V
Slc2a1										V
Chuk										V
Ikbkb										V
Mapk9										V
Akt2										V
Akt3										V
Traf2										V
Irs3										V
Irs2										V
Tnfrsf1a										V
+ 03320: PPAR signaling pathway	5	2.7	2.1	3.9	1.7	3.2	2.2	0.7	7.9	1.6
Gk	V				V				V
Plin2	V			V	V			V		V
Cd36	V				V					V
Fabp4	V					V	V			V
Fabp2	V								V
Pparg	V					V				V
Scp2	V	V		V		V			V
Acaa1a	V								V	V
Acaa1b	V			V					V
Acadm	V									V
Cpt1a	V				V				V
Acox1	V							V	V	V
Fads2	V								V
Apoa5	V								V
Fabp5		V			V					V
Cyp4a12b		V							V
Cyp4a12a		V							V
Acsl4		V							V
Apoa2		V				V			V
Nr1h3		V							V	V
Slc27a5			V						V
Rxra			V	V					V
Acsl1			V		V				V	V
Cyp7a1			V						V
Slc27a1				V		V				V
Acsl3				V					V
Hmgcs1				V	V				V
Me1				V						V
Fabp7					V				V
Acsl5					V					V
Olr1					V
Sorbs1					V				V	V
Angptl4					V					V
Pltp					V			V		V
Pck1						V	V
Plin1						V				V
Hmgcs2						V			V
Ilk						V	V			V
Adipoq						V	V			V
Apoc3						V			V
Cyp27a1						V			V
Apoa1						V			V
Dbi						V				V
Lpl							V		V	V
Acox3							V		V
Slc27a2									V
Fabp1									V
Ppara									V
Rxrb									V	V
Cyp4a32									V
Cyp4a10									V
Cyp4a14									V
Cyp4a31									V
Acox2									V
Scd3									V
Cyp8b1									V
Aqp7										V
Pck2										V
Plin4										V
Plin5										V
Fabp3										V
Rxrg										V
Ppard										V
Cpt2										V
Cpt1c										V
Acsbg1										V
Scd2										V
+ 04929: GnRH secretion	2.1	0	0	1.7	1.2	0.9	0	0.6	0.4	1.9
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Arrb1	V				V					V
Kcnn1	V
Itpr1				V						V
Kcnn2				V					V
Pik3cd					V
Akt1					V					V
Mapk1					V			V		V
Arrb2					V				V	V
Spp1					V				V
Kcnn4					V					V
Cacna1d					V					V
Pik3r2						V				V
Raf1						V		V		V
Gnaq									V
Kras									V
Gabbr2									V
Gna11										V
Itpr3										V
Prkcb										V
Pik3r3										V
Akt2										V
Akt3										V
Map2k1										V
Kiss1r										V
Trpc1										V
Gabbr1										V
Hcn2										V
Gper1										V
Cacna1c										V
+ 04912: GnRH signaling pathway	2.3	0.4	1.5	1.3	2.2	0.2	0.1	1.1	0.2	3.4
Adcy6	V					V				V
Map2k6	V		V		V
Mapk3	V					V				V
Grb2	V	V			V					V
Mapk8	V
Jun	V									V
Egr1	V			V	V					V
Egfr		V							V
Map2k3			V
Mapk14			V	V	V				V
Itpr1				V						V
Prkcd					V			V		V
Adcy3					V					V
Adcy7					V
Mapk12					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Mmp2					V					V
Cacna1d					V					V
Mapk1					V			V		V
Hbegf					V
Gnas						V				V
Raf1						V		V		V
Src							V	V
Adcy9									V
Gnaq									V
Kras									V
Sos1									V
Map2k7									V	V
Prkcb										V
Adcy4										V
Adcy5										V
Cdc42										V
Atf4										V
Camk2d										V
Camk2a										V
Camk2g										V
Mapk11										V
Map3k3										V
Mapk7										V
Pla2g4a										V
Itpr3										V
Calml4										V
Gna11										V
Mmp14										V
Pld2										V
Prkaca										V
Cacna1c										V
Elk1										V
Map2k1										V
Ptk2b										V
Map2k4										V
Mapk9										V
+ 04913: Ovarian steroidogenesis	1.6	1.3	1.3	1.1	0.2	0.7	0.3	0.2	2	0.3
Hsd3b2	V		V						V
Cyp17a1	V								V
Adcy6	V					V				V
Acot2	V					V				V
Hsd17b2		V							V
Igf1		V	V						V
Bmp6		V					V			V
Hsd17b7				V	V				V
Ldlr				V	V			V	V	V
Adcy3					V					V
Adcy7					V
Gnas						V				V
Alox5						V				V
Hsd3b5									V
Adcy9									V
Cyp2j5									V
Cyp2j6									V
Scarb1									V	V
Star										V
Adcy4										V
Adcy5										V
Cyp1b1										V
Prkaca										V
Igf1r										V
Cyp2j9										V
Pla2g4a										V
+ 04915: Estrogen signaling pathway	1.6	1.1	0.6	0.9	1.9	1.2	0.4	2.1	0.7	1.8
Jun	V									V
Mapk3	V					V				V
Adcy6	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Grb2	V	V			V					V
Krt23	V
Egfr		V							V
Hsp90aa1		V					V		V
Hsp90b1		V							V
Ctsd		V			V			V		V
Esr1			V					V
Ncoa2			V
Creb3l2				V
Itpr1				V						V
Mmp2					V					V
Hbegf					V
Fos					V					V
Mapk1					V			V		V
Creb3					V					V
Prkcd					V			V		V
Adcy3					V					V
Adcy7					V
Pik3cd					V
Akt1					V					V
Shc2					V					V
Hspa8					V			V	V	V
Gnao1					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Rara					V			V	V
Mmp9						V				V
Raf1						V		V		V
Pik3r2						V				V
Fkbp5						V				V
Gnas						V				V
Gnai1						V	V			V
Krt19						V				V
Src							V	V
Kras									V
Creb3l3									V
Gnaq									V
Adcy9									V
Gabbr2									V
Sos1									V
Hsp90ab1									V	V
Fkbp4									V
Krt18									V
Tgfa									V
Gper1										V
Prkaca										V
Map2k1										V
Atf4										V
Creb3l1										V
Adcy4										V
Adcy5										V
Gabbr1										V
Pik3r3										V
Akt2										V
Akt3										V
Nos3										V
Hspa2										V
Hspa1a										V
Gnai2										V
Itpr3										V
Calml4										V
Ncoa1										V
Bcl2										V
Krt14										V
+ 04914: Progesterone-mediated oocyte maturation	1.9	0.4	0.9	1.3	3	1.8	0.8	0.3	0.1	2.8
Adcy6	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Rps6ka1	V			V	V
Mapk3	V					V				V
Mapk8	V
Igf1		V	V						V
Hsp90aa1		V					V		V
Mapk14			V	V	V				V
Adcy3					V					V
Adcy7					V
Ccnb1					V
Cdk1					V
Pik3cd					V
Akt1					V					V
Mad2l1					V
Bub1					V
Plk1					V
Ccnb2					V
Rps6ka2					V					V
Mapk1					V			V		V
Ccna2					V
Mapk12					V					V
Stk10					V					V
Kif22					V
Pik3r2						V				V
Pde3b						V	V			V
Anapc13						V				V
Gnai1						V	V			V
Braf						V
Raf1						V		V		V
Adcy9									V
Kras									V
Hsp90ab1									V	V
Igf1r										V
Cpeb1										V
Adcy4										V
Adcy5										V
Pik3r3										V
Akt2										V
Akt3										V
Anapc1										V
Cdc27										V
Anapc4										V
Cdc23										V
Anapc5										V
Anapc11										V
Cdc16										V
Anapc2										V
Cdc25b										V
Prkaca										V
Pkmyt1										V
Rps6ka3										V
Map2k1										V
Gnai2										V
Mapk11										V
Mapk9										V
Araf										V
+ 04917: Prolactin signaling pathway	3.6	2.1	1.1	1.6	2.6	1.7	1.1	2.8	1.1	0.9
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Stat1	V				V				V	V
Grb2	V	V			V					V
Mapk8	V
Gck	V			V					V
Cyp17a1	V								V
Gsk3b	V									V
Stat3		V			V			V
Socs2		V				V
Ccnd1		V			V				V
Rela		V						V	V
Mapk14			V	V	V				V
Esr1			V					V
Akt1					V					V
Pik3cd					V
Mapk1					V			V		V
Stat5b					V
Shc2					V					V
Mapk12					V					V
Socs5					V
Fos					V					V
Tnfrsf11a					V			V		V
Pik3r2						V				V
Raf1						V		V		V
Prlr						V			V
Galt						V	V
Stat5a							V			V
Src							V	V
Kras									V
Sos1									V
Slc2a2									V
Akt2										V
Akt3										V
Pik3r3										V
Map2k1										V
Mapk9										V
Mapk11										V
Cish										V
Ccnd2										V
Nfkb1										V
+ 04921: Oxytocin signaling pathway	0.4	0.1	0	1.2	2.3	0.7	1.3	1.1	0	4.4
Adcy6	V					V				V
Mapk3	V					V				V
Prkag2	V					V				V
Jun	V									V
Ccnd1		V			V				V
Egfr		V							V
Itpr1				V						V
Myl6				V			V			V
Rcan1				V	V			V	V	V
Cdkn1a				V	V			V		V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Adcy3					V					V
Adcy7					V
Oxtr					V
Mapk1					V			V		V
Actb					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Cacna1d					V					V
Cacng5					V
Prkab1					V	V			V	V
Nfatc1					V					V
Fos					V					V
Gnao1					V					V
Pik3cg					V					V
Pik3r5					V			V		V
Kcnj2					V
Kcnj14					V
Gnas						V				V
Raf1						V		V		V
Eef2k						V				V
Gucy1a1						V				V
Npr2						V				V
Gnai1						V	V			V
Prkab2							V			V
Prkag3							V
Ppp3ca							V			V
Src							V	V
Gnaq									V
Adcy9									V
Kras									V
Eef2									V
Camkk2									V
Prkaa2									V
Mylk										V
Itpr3										V
Calml4										V
Adcy4										V
Adcy5										V
Prkaca										V
Prkcb										V
Map2k1										V
Pla2g4a										V
Camk2d										V
Camk2a										V
Camk2g										V
Camk1										V
Nos3										V
Gucy1b1										V
Myl9										V
Actg1										V
Rhoa										V
Rock1										V
Ppp1r12a										V
Ppp1ca										V
Ppp1r12c										V
Ppp1r12b										V
Cacna1c										V
Cacna2d1										V
Cacnb1										V
Cacnb3										V
Cacng7										V
Prkaa1										V
Prkag1										V
Map2k5										V
Mapk7										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Nfatc4										V
Rgs2										V
Elk1										V
Cd38										V
Gnai2										V
+ 04926: Relaxin signaling pathway	2.4	0.4	0.6	1.8	3.2	1.5	0.5	1	0.1	5.6
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Col3a1	V			V	V					V
Adcy6	V					V				V
Jun	V									V
Mapk8	V
Grb2	V	V			V					V
Arrb1	V				V					V
Rela		V						V	V
Egfr		V							V
Gnb2			V							V
Mapk14			V	V	V				V
Nfkbia				V				V		V
Creb3l2				V
Akt1					V					V
Mapk1					V			V		V
Pik3cd					V
Gng2					V					V
Creb3					V					V
Gnao1					V					V
Mmp2					V					V
Tgfb1					V					V
Smad2					V					V
Col4a1					V					V
Col4a2					V					V
Col1a1					V					V
Mmp13					V
Adcy3					V					V
Adcy7					V
Shc2					V					V
Fos					V					V
Gna15					V					V
Mapk12					V					V
Arrb2					V				V	V
Pik3r2						V				V
Gnb1						V				V
Gnb5						V				V
Gnas						V				V
Gnai1						V	V			V
Vegfb						V	V			V
Mmp9						V				V
Raf1						V		V		V
Src							V	V
Creb3l3									V
Prkcz									V	V
Adcy9									V
Kras									V
Sos1									V
Map2k7									V	V
Akt2										V
Akt3										V
Nfkb1										V
Nos3										V
Pik3r3										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Atf4										V
Creb3l1										V
Adcy5										V
Prkaca										V
Edn1										V
Ednrb										V
Gnai2										V
Vegfd										V
Vegfc										V
Nos2										V
Acta2										V
Col4a4										V
Col4a5										V
Col1a2										V
Col4a6										V
Adcy4										V
Map2k1										V
Tgfbr2										V
Map2k4										V
Mapk11										V
Mapk9										V
+ 04935: Growth hormone synthesis, secretion and action	2.6	1.3	1.7	1.5	2.2	1.8	1.3	0.8	0.2	2.5
Adcy6	V					V				V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Gsk3b	V									V
Stat1	V				V				V	V
Grb2	V	V			V					V
Map2k6	V		V		V
Mapk8	V
Irs1		V				V
Igf1		V	V						V
Socs2		V				V
Stat3		V			V			V
Mapk14			V	V	V				V
Map2k3			V
Itpr1				V						V
Creb3l2				V
Plcg2					V			V		V
Adcy3					V					V
Adcy7					V
Mapk1					V			V		V
Cacna1d					V					V
Creb3					V					V
Pik3cd					V
Akt1					V					V
Fos					V					V
Junb					V
Mapk12					V					V
Stat5b					V
Shc2					V					V
Raf1						V		V		V
Ghr						V	V			V
Gnas						V				V
Pik3r2						V				V
Ptk2						V	V			V
Gnai1						V	V			V
Mtor							V			V
Stat5a							V			V
Gnaq									V
Adcy9									V
Creb3l3									V
Kras									V
Sstr2									V
Sos1									V
Igfals									V
Itpr3										V
Plcg1										V
Gna11										V
Adcy4										V
Adcy5										V
Map2k1										V
Prkcb										V
Cacna1c										V
Prkaca										V
Atf4										V
Creb3l1										V
Irs3										V
Irs2										V
Pik3r3										V
Akt2										V
Akt3										V
Mapk11										V
Sst										V
Gnai2										V
Map2k4										V
Mapk9										V
Igfbp3										V
+ 04918: Thyroid hormone synthesis	0.5	1.1	0	2.7	0.2	1	0.2	0	2.3	0.8
Adcy6	V					V				V
Ttf1	V
Hspa5		V		V					V
Hsp90b1		V							V
Pdia4		V		V					V
Atp1b1				V
Creb3l2				V
Itpr1				V						V
Adcy3					V					V
Adcy7					V
Atp1a1					V				V
Ttf2					V
Creb3					V					V
Gnas						V				V
Atp1a2						V				V
Gpx3						V				V
Gpx8						V				V
Alb						V			V
Fxyd2							V			V
Gnaq									V
Adcy9									V
Iyd									V
Creb3l3									V
Canx									V
Asgr1									V
Asgr2									V
Ttr									V
Serpina7									V
Prkaca										V
Tshr										V
Adcy4										V
Adcy5										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Prkcb										V
Atf4										V
Creb3l1										V
Itpr3										V
Lrp2										V
Gpx7										V
Gsr										V
+ 04919: Thyroid hormone signaling pathway	3	0.5	2.2	2	2.1	1.8	2.6	2.3	1	4.6
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ctnnb1	V				V					V
Gsk3b	V									V
Stat1	V				V				V	V
Mapk3	V					V				V
Rcan2	V									V
Med16	V					V	V			V
Med14	V									V
Mdm2	V	V			V					V
Atp2a2		V			V				V
Ccnd1		V			V				V
Thra			V	V		V				V
Esr1			V					V
Rxra			V	V					V
Ncor1			V
Ncoa2			V
Rcan1				V	V			V	V	V
Atp1b1				V
Akt1					V					V
Pik3cd					V
Plcg2					V			V		V
Hif1a					V			V	V
Atp2a3					V		V			V
Mapk1					V			V		V
Atp1a1					V				V
Actb					V					V
Slc16a10					V				V
Med24					V	V
Notch2					V			V	V
Notch4					V		V			V
Pik3r2						V				V
Plcd1						V				V
Raf1						V		V		V
Tbc1d4						V				V
Atp1a2						V				V
Bmp4						V				V
Plce1							V			V
Mtor							V			V
Myh6							V
Fxyd2							V			V
Src							V	V
Kras									V
Gata4									V
Slc16a2									V
Rxrb									V	V
Sin3a									V	V
Med13									V
Akt2										V
Akt3										V
Pik3r3										V
Prkcb										V
Plcg1										V
Plcd3										V
Map2k1										V
Prkaca										V
Slc2a1										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Actg1										V
Dio3										V
Rxrg										V
Hdac1										V
Ncoa1										V
Med12										V
Med4										V
Med27										V
Med30										V
Tsc2										V
Rheb										V
Bad										V
Foxo1										V
Casp9										V
Pfkp										V
Notch1										V
Notch3										V
Myc										V
+ 04928: Parathyroid hormone synthesis, secretion and action	1.2	0.1	0.3	2.1	1.9	0.6	0.1	0.9	0.3	1.5
Adcy6	V					V				V
Pth1r	V					V			V	V
Arrb1	V				V					V
Mapk3	V					V				V
Egr1	V			V	V					V
Egfr		V							V
Rxra			V	V					V
Itpr1				V						V
Creb3l2				V
Cdkn1a				V	V			V		V
Adcy3					V					V
Adcy7					V
Arrb2					V				V	V
Mapk1					V			V		V
Gna12					V
Gna13					V					V
Arhgef1					V					V
Creb3					V					V
Fos					V					V
Mmp13					V
Mef2d					V			V
Mafb					V
Hbegf					V
Gnas						V				V
Gnai1						V	V			V
Braf						V
Raf1						V		V		V
Gnaq									V
Adcy9									V
Mmp15									V
Slc9a3r1									V
Creb3l3									V
Rxrb									V	V
Itpr3										V
Gna11										V
Adcy4										V
Adcy5										V
Prkaca										V
Gnai2										V
Araf										V
Map2k1										V
Prkcb										V
Mmp14										V
Mmp17										V
Rhoa										V
Pld2										V
Atf4										V
Creb3l1										V
Bcl2										V
Naca										V
Jund										V
Mef2a										V
Fgfr1										V
Rxrg										V
+ 04916: Melanogenesis	1.7	0	0.8	0.2	1.4	0.5	0.1	0.3	0	2.8
Fzd4	V		V							V
Fzd8	V
Adcy6	V					V				V
Gsk3b	V									V
Ctnnb1	V				V					V
Mapk3	V					V				V
Kit			V
Creb3l2				V
Dvl1					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gnao1					V					V
Creb3					V					V
Adcy3					V					V
Adcy7					V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Mapk1					V			V		V
Gnai1						V	V			V
Gnas						V				V
Wnt2b						V				V
Raf1						V		V		V
Creb3l3									V
Adcy9									V
Gnaq									V
Wnt2									V
Wnt5b									V	V
Kras									V
Dvl2										V
Mitf										V
Prkaca										V
Camk2d										V
Camk2a										V
Camk2g										V
Calml4										V
Gnai2										V
Ednrb										V
Fzd1										V
Fzd6										V
Fzd2										V
a										V
Tcf7l1										V
Tcf7l2										V
Prkcb										V
Creb3l1										V
Adcy4										V
Adcy5										V
Wnt9a										V
Wnt6										V
Map2k1										V
Edn1										V
+ 04924: Renin secretion	0.1	0.2	0	0.4	1	1.2	2	0.1	0	2.7
Adcy6	V					V				V
Adora1		V
Itpr1				V						V
Ctsb					V			V		V
Ace					V					V
Ptger4					V					V
Pde1b					V					V
Cacna1d					V					V
Kcnj2					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gnas						V				V
Adrb3						V				V
Gnai1						V	V			V
Gucy1a1						V				V
Pde3b						V	V			V
Agt						V	V
Agtr1a							V
Ppp3ca							V			V
Gnaq									V
Adcy5										V
Prkaca										V
Adrb1										V
Adrb2										V
Gnai2										V
Orai1										V
Itpr3										V
Gucy1b1										V
Pde3a										V
Ptger2										V
Ednra										V
Cacna1c										V
Calml4										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Aqp1										V
Edn1										V
+ 04614: Renin-angiotensin system	0	0	0	1.5	1.5	0.8	1.2	1.1	0.5	0.4
Nln				V					V
Enpep				V		V				V
Ace					V					V
Mme					V				V	V
Anpep					V			V	V
Ctsa					V	V		V	V	V
Atp6ap2					V					V
Prcp					V					V
Agt						V	V
Agtr1a							V
Cpa3										V
Lnpep										V
Mcpt4										V
Cma1										V
+ 04925: Aldosterone synthesis and secretion	0.2	0.1	0.8	1.7	1.3	0.5	1.1	0.3	0.6	2.5
Adcy6	V					V				V
Hsd3b2	V		V						V
Prkd3		V							V
Atp2b4			V							V
Itpr1				V						V
Creb3l2				V
Ldlr				V	V			V	V	V
Atp1b1				V
Kcnk3					V					V
Cacna1d					V					V
Creb3					V					V
Adcy3					V					V
Adcy7					V
Pde2a					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Daglb					V
Atp1a1					V				V
Atp2b1					V					V
Gnas						V				V
Prkd1						V				V
Lipe						V	V			V
Atp1a2						V				V
Agt						V	V
Agtr1a							V
Prkd2							V			V
Atf1								V
Gnaq									V
Creb3l3									V
Adcy9									V
Hsd3b5									V
Scarb1									V	V
Cyp21a1									V
Atp2b2									V
Itpr3										V
Cacna1c										V
Gna11										V
Atf4										V
Creb3l1										V
Adcy4										V
Adcy5										V
Calml4										V
Mc2r										V
Prkcb										V
Prkce										V
Camk2d										V
Camk2a										V
Camk2g										V
Camk1										V
Nr4a1										V
Star										V
Prkaca										V
Orai1										V
Dagla										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
+ 04927: Cortisol synthesis and secretion	0.9	0	0.5	1.6	0.9	0.5	0.6	0.5	1.2	1.2
Adcy6	V					V				V
Hsd3b2	V		V						V
Cyp17a1	V								V
Itpr1				V						V
Creb3l2				V
Ldlr				V	V			V	V	V
Cacna1d					V					V
Creb3					V					V
Adcy3					V					V
Adcy7					V
Pde8a					V
Nceh1					V			V	V
Kcnk3					V					V
Gnas						V				V
Mrap						V				V
Agt						V	V
Agtr1a							V
Gnaq									V
Creb3l3									V
Adcy9									V
Hsd3b5									V
Scarb1									V	V
Cyp21a1									V
Itpr3										V
Cacna1c										V
Gna11										V
Atf4										V
Creb3l1										V
Adcy4										V
Adcy5										V
Mc2r										V
Star										V
Prkaca										V
Orai1										V
Kcnk2										V
Nr4a1										V
Pbx1										V
+ 5.3 Circulatory system	0.7	0.8	0.6	1.3	4.1	3.8	3.6	0.7	0.1	5.1
+ 04260: Cardiac muscle contraction	0.3	0.4	0.4	0.3	1.7	4.1	3.1	0.1	0	1.4
Tpm2	V									V
Cox4i1	V					V				V
Atp2a2		V			V				V
Tpm1		V			V			V		V
Cox5a			V
Atp1b1				V
Cacna1d					V					V
Cacng5					V
Atp2a3					V		V			V
Tnnc1					V
Actc1					V
Tpm4					V					V
Tpm3					V	V				V
Cox6a2					V
Atp1a1					V				V
Trdn					V
Asph					V	V	V			V
Cox6a1						V				V
Cox6c						V				V
Cox7a2						V			V	V
Cox7c						V
COX2						V
COX3						V
Uqcrq						V				V
Uqcr10						V
Cyc1						V	V			V
Uqcr11						V
Uqcrfs1						V				V
Uqcrc2						V			V
Atp1a2						V				V
Myh6							V
Myl2							V
Cox7a1							V
Fxyd2							V			V
Casq2							V			V
Cacna1c										V
Cacna2d1										V
Cacnb1										V
Cacnb3										V
Cacng7										V
Cox6b1										V
Cox8a										V
Cox8b										V
Cox7a2l										V
Uqcrc1										V
Cox6b2										V
Cox4i2										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
+ 04261: Adrenergic signaling in cardiomyocytes	0.4	0.6	0.5	1.2	3.7	1.2	1.7	0.8	0	4.3
Tpm2	V									V
Adcy6	V					V				V
Mapk3	V					V				V
Ppp2r1b	V					V				V
Atp2a2		V			V				V
Tpm1		V			V			V		V
Rapgef4		V							V	V
Crem		V		V	V				V
Mapk14			V	V	V				V
Atp2b4			V							V
Atp1b1				V
Creb3l2				V
Cacna1d					V					V
Cacng5					V
Atp2a3					V		V			V
Tnnc1					V
Actc1					V
Tpm4					V					V
Tpm3					V	V				V
Atp1a1					V				V
Adcy3					V					V
Adcy7					V
Pik3cg					V					V
Pik3r5					V			V		V
Akt1					V					V
Mapk1					V			V		V
Creb3					V					V
Scn1b					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Ppp2r5b					V					V
Ppp2r5c					V			V		V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Mapk12					V					V
Atp2b1					V					V
Atp1a2						V				V
Gnas						V				V
Gnai1						V	V			V
Scn7a						V				V
Ppp1r1a						V				V
Ppp2r3a						V
Rapgef3						V		V		V
Agt						V	V
Myh6							V
Myl2							V
Fxyd2							V			V
Agtr1a							V
Adcy9									V
Creb3l3									V
Gnaq									V
Adra1b									V
Atp2b2									V
Cacna1c										V
Cacna2d1										V
Cacnb1										V
Cacnb3										V
Cacng7										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Adrb1										V
Adrb2										V
Gnai2										V
Adcy4										V
Adcy5										V
Prkaca										V
Akt2										V
Akt3										V
Atf4										V
Creb3l1										V
Ppp1ca										V
Ppp2ca										V
Ppp2cb										V
Ppp2r5a										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r3c										V
Ppp2r2a										V
Ppp2r2b										V
Calml4										V
Camk2d										V
Camk2a										V
Camk2g										V
Mapk11										V
Adra1d										V
Bcl2										V
Rps6ka5										V
+ 04270: Vascular smooth muscle contraction	0.5	0.4	0.2	0.8	1.7	1.3	1.4	0.3	0.2	3.1
Pla2g6	V			V	V	V	V			V
Mapk3	V					V				V
Adcy6	V					V				V
Ramp2	V				V		V			V
Cyp4a12b		V							V
Cyp4a12a		V							V
Avpr1a		V	V			V			V
Myl6				V			V			V
Itpr1				V						V
Ppp1cc					V					V
Ppp1ccb					V					V
Prkcd					V			V		V
Prkch					V					V
Arhgef1					V					V
Gna12					V
Gna13					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Cacna1d					V					V
Pla2g2e					V					V
Cald1					V				V	V
Mapk1					V			V		V
Adcy3					V					V
Adcy7					V
Ptgir					V					V
Pla2g2d						V				V
Pla2g12a						V				V
Braf						V
Raf1						V		V		V
Gucy1a1						V				V
Gnas						V				V
Npr2						V				V
Agt						V	V
Ppp1r14a							V			V
Agtr1a							V
Adra1b									V
Gnaq									V
Cyp4a32									V
Cyp4a10									V
Cyp4a14									V
Cyp4a31									V
Pla2g12b									V
Adcy9									V
Mylk										V
Myl9										V
Ppp1r12a										V
Ppp1ca										V
Ppp1r12c										V
Ppp1r12b										V
Rock1										V
Prkcb										V
Prkce										V
Rhoa										V
Acta2										V
Adra1d										V
Gna11										V
Itpr3										V
Calml4										V
Cacna1c										V
Pla2g4a										V
Araf										V
Map2k1										V
Adora2a										V
Adora2b										V
Adcy4										V
Adcy5										V
Prkaca										V
Gucy1b1										V
Ednra										V
Ramp1										V
Myh11										V
Edn1										V
Calca										V
Adm										V
+ 5.4 Digestive system	3.7	1	2.8	4.9	3.9	3.8	2.3	2	7.6	3.9
+ 04970: Salivary secretion	0.1	0	0.4	0.9	0.9	1.5	0.2	0	0.2	2.5
Adcy6	V					V				V
Atp2b4			V							V
Itpr1				V						V
Atp1b1				V
Adcy3					V					V
Adcy7					V
Atp2b1					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Kcnn4					V					V
Atp1a1					V				V
Lyz2					V					V
Adrb3						V				V
Gnas						V				V
Vamp2						V				V
Aqp5						V				V
Gucy1a1						V				V
Atp1a2						V				V
Lyz1						V				V
Fxyd2							V			V
Adra1b									V
Adcy9									V
Gnaq									V
Atp2b2									V
Slc4a2									V
Adrb1										V
Adrb2										V
Adra1d										V
Slc12a2										V
Adcy4										V
Adcy5										V
Prkaca										V
Itpr3										V
Prkcb										V
Calml4										V
Gucy1b1										V
Cd38										V
Cst3										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
+ 04971: Gastric acid secretion	0.1	0	0	0.9	1.1	0.4	0.2	0	0.1	1.7
Adcy6	V					V				V
Itpr1				V						V
Atp1b1				V
Adcy3					V					V
Adcy7					V
Atp1a1					V				V
Slc9a4					V
Kcnj2					V
Actb					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gnas						V				V
Atp1a2						V				V
Gnai1						V	V			V
Adcy9									V
Gnaq									V
Slc4a2									V
Sstr2									V
Adcy4										V
Adcy5										V
Prkaca										V
Itpr3										V
Prkcb										V
Kcnk2										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Ezr										V
Gnai2										V
Sst										V
Kcnj15										V
Calml4										V
Mylk										V
Camk2d										V
Camk2a										V
Camk2g										V
+ 04972: Pancreatic secretion	0	0.1	0.3	0.6	0.7	0.4	0.6	0.1	0.3	0.7
Adcy6	V					V				V
Atp2a2		V			V				V
Atp2b4			V							V
Itpr1				V						V
Atp1b1				V
Atp2b1					V					V
Atp1a1					V				V
Tpcn2					V					V
Cpa2					V
Pla2g2e					V					V
Atp2a3					V		V			V
Adcy3					V					V
Adcy7					V
Rap1b					V					V
Cck					V					V
Atp1a2						V				V
Amy1						V	V		V	V
Pla2g2d						V				V
Pla2g12a						V				V
Gnas						V				V
Fxyd2							V			V
Rap1a								V		V
Gnaq									V
Atp2b2									V
Slc4a2									V
Cpb2									V
Pla2g12b									V
Adcy9									V
Rab8a									V
Slc12a2										V
Itpr3										V
Prkcb										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Sctr										V
Slc4a4										V
Cpa3										V
Trpc1										V
Cd38										V
Adcy4										V
Adcy5										V
Rab3d										V
Rab11a										V
Rhoa										V
Rac1										V
+ 04976: Bile secretion	2.3	0.6	3.4	3.7	0.8	0.4	0.2	0.5	6.4	0.3
Adcy6	V					V				V
Abcc3	V				V				V
Abcg5	V								V
Abcg8	V								V
Abcb1a	V					V				V
Aqp8	V			V					V
Slco1a1		V	V						V
Ephx1		V			V				V
Slc10a1			V						V
Cyp7a1			V						V
Nr1h4			V						V
Slc27a5			V						V
Rxra			V	V					V
Atp1b1				V
Nr0b2				V					V
Kcnn2				V					V
Ldlr				V	V			V	V	V
Hmgcr				V					V
Atp1a1					V				V
Adcy3					V					V
Adcy7					V
Abcb4					V				V
Nceh1					V			V	V
Atp1a2						V				V
Gnas						V				V
Fxyd2							V			V
Aqp9									V
Slc4a2									V
Adcy9									V
Slco1a4									V
Slco1b2									V
Abcb11									V
Abcc2									V
Slc22a1									V
Slc10a2									V
Baat									V
Scarb1									V	V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Sctr										V
Slc4a4										V
Adcy4										V
Adcy5										V
Prkaca										V
Abcc4										V
Abcb1b										V
Slc2a1										V
Aqp1										V
+ 04973: Carbohydrate digestion and absorption	0.8	0	0	1.4	0.7	1.8	1	0.3	0.9	1.5
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Atp1b1				V
Atp1a1					V				V
Cacna1d					V					V
Hk3					V			V
Pik3cd					V
Akt1					V					V
Slc2a5						V			V
Atp1a2						V				V
Amy1						V	V		V	V
Pik3r2						V				V
Fxyd2							V			V
Slc2a2									V
Slc37a4									V
G6pc									V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Hk1										V
Hk2										V
G6pc3										V
Pik3r3										V
Akt2										V
Akt3										V
Prkcb										V
+ 04974: Protein digestion and absorption	0.3	0.1	0.3	0.7	3.7	0.1	0.4	0.3	0.5	1.4
Col3a1	V			V	V					V
Col27a1	V								V
Col13a1		V	V						V
Atp1b1				V
Slc38a2					V				V
Slc7a7					V					V
Atp1a1					V				V
Cpa2					V
Kcnn4					V					V
Slc36a1					V			V
Slc36a4					V					V
Slc36a2					V					V
Mme					V				V	V
Prcp					V					V
Col15a1					V					V
Col4a1					V					V
Col4a2					V					V
Col5a1					V					V
Col5a2					V					V
Col6a2					V					V
Col1a1					V					V
Col28a1					V			V
Col5a3					V					V
Slc16a10					V				V
Slc1a5						V	V			V
Atp1a2						V				V
Dpp4						V			V
Fxyd2							V			V
Slc3a1									V
Cpb2									V
Kcnk5									V
Slc1a1										V
Slc7a8										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Slc3a2										V
Cpa3										V
Xpnpep2										V
Eln										V
Col4a4										V
Col4a5										V
Col6a1										V
Col1a2										V
Col6a6										V
Col6a5										V
Col4a6										V
+ 04975: Fat digestion and absorption	3.7	0.4	0.8	0.7	0.6	2.5	0.4	0	2.9	0.7
Abcg5	V								V
Abcg8	V								V
Cd36	V				V					V
Agpat2	V					V				V
Dgat1	V					V	V			V
Apoa4	V			V					V
Fabp2	V								V
Apob		V	V						V
Pla2g2e					V					V
Mogat2					V					V
Acat2					V	V				V
Pla2g2d						V				V
Pla2g12a						V				V
Agpat1						V				V
Apoa1						V			V
Pla2g12b									V
Mttp									V
Scarb1									V	V
Fabp1									V
Got2									V
Dgat2										V
Plpp1										V
Plpp3										V
+ 04979: Cholesterol metabolism	2.9	0.9	2.1	3.2	3	2.1	2.1	4.4	7.2	2.2
Apoa4	V			V					V
Cd36	V				V					V
Lipg	V			V					V
Vdac1	V									V
Abcg5	V								V
Abcg8	V								V
Apob		V	V						V
Apoa2		V				V			V
Osbpl5			V							V
Cyp7a1			V						V
Ldlr				V	V			V	V	V
Pcsk9				V					V
Lipa				V	V			V	V
Angptl4					V					V
Nceh1					V			V	V
Soat1					V			V		V
Pltp					V			V		V
Ldlrap1					V
Stard3					V			V	V
Npc1					V			V	V
Npc2					V			V		V
Lrp1					V			V
Apoa1						V			V
Apoc1						V	V		V
Apoc3						V			V
Apoe						V	V		V	V
Tspo						V	V			V
Cyp27a1						V			V
Lpl							V		V	V
Angptl3									V
Angptl8									V
Apoh									V
Lcat									V
Lipc									V
Scarb1									V	V
Abcb11									V
Gm44805										V
Apoc2										V
Mylip										V
Vapa										V
Vapb										V
Star										V
Vdac2										V
Vdac3										V
Lrp2										V
Lrpap1										V
+ 04977: Vitamin digestion and absorption	1.4	0.7	1	1	0	1.3	1.5	0	3.8	0.7
Apoa4	V			V					V
Tcn2	V					V	V			V
Apob		V	V						V
Apoa1						V			V
Slc5a6						V	V			V
Scarb1									V	V
Lrat									V
Slc23a1									V
Slc19a1									V	V
Slc19a2									V
Btd									V
Slc46a1									V
Abcc1										V
Mmachc										V
Folh1										V
Slc52a3										V
+ 04978: Mineral absorption	0.2	0.3	0.6	2.5	0.8	1.6	0.9	0.8	1.9	0.6
Steap2	V					V				V
Slc39a4		V				V			V
Atp2b4			V							V
LOC100862446				V	V				V
Ftl1				V	V				V
Fth1				V				V		V
Atp1b1				V
Atp2b1					V					V
Hmox1					V			V		V
Slc31a1					V				V
Atp1a1					V				V
Heph						V				V
Mt1						V				V
Atp1a2						V				V
Clcn2						V
Slc40a1							V		V
Fxyd2							V			V
Atp2b2									V
Slc46a1									V
Slc11a2									V	V
Slc30a1									V
Cybrd1										V
Mt2										V
Atox1										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
+ 5.5 Excretory system	2.6	1.3	1.5	2.4	2.2	2.8	1.9	2.2	1.2	4.2
+ 04962: Vasopressin-regulated water reabsorption	0.3	1	0.7	1.4	1.5	1.5	0.4	0	0.4	3.7
Adcy6	V					V				V
Arhgdia		V								V
Dynll1		V			V					V
Dctn6			V			V				V
Creb3l2				V
Dync1li2				V	V				V	V
Adcy3					V					V
Creb3					V					V
Arhgdib					V					V
Rab5c					V					V
Dctn5					V					V
Gnas						V				V
Vamp2						V				V
Dync2li1						V				V
Rab11b							V			V
Adcy9									V
Creb3l3									V
Dync1i2									V	V
Prkaca										V
Creb3l1										V
Aqp2										V
Arhgdig										V
Rab11a										V
Dctn1										V
Dctn4										V
Dctn2										V
Dync1h1										V
Dync1li1										V
+ 04960: Aldosterone-regulated sodium reabsorption	2.2	1.1	0.8	1.5	0.3	2.6	0.5	1	0.2	1.6
Scnn1a	V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Irs1		V				V
Igf1		V	V						V
Atp1b1				V
Atp1a1					V				V
Pik3cd					V
Mapk1					V			V		V
Atp1a2						V				V
Pik3r2						V				V
Sfn						V				V
Fxyd2							V			V
Sgk1								V		V
Kras									V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Nr3c2										V
Pik3r3										V
Prkcb										V
Slc9a3r2										V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	1.1	0.7	1.9	0.5	0.2	0.6	0.3	0.6	0.4	0.9
Pth1r	V					V			V	V
Clta	V							V		V
Adcy6	V					V				V
Cltc		V								V
Ap2a1		V								V
Atp2b4			V							V
Ap2b1			V
Esr1			V					V
Atp1b1				V
Atp2b1					V					V
Ap2m1					V				V
Dnm1					V					V
Atp1a1					V				V
Gnas						V				V
Atp1a2						V				V
Fxyd2							V			V
Atp2b2									V
Gnaq									V
Adcy9									V
Cltb										V
Ap2s1										V
Rab11a										V
Dnm2										V
Prkcb										V
Prkaca										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
+ 04964: Proximal tubule bicarbonate reclamation	2.2	0	0	1.9	0.4	1.4	2.4	0	1.7	1.6
Gls2	V			V					V
Slc38a3	V								V
Slc25a10	V				V	V	V		V	V
Atp1b1				V
Atp1a1					V				V
Atp1a2						V				V
Pck1						V	V
Fxyd2							V			V
Glud1									V
Slc4a4										V
Gls										V
Atp1b2										V
Atp1b3										V
Atp1a3										V
Aqp1										V
Pck2										V
+ 04966: Collecting duct acid secretion	0	0	0	0	2.5	0.2	0.7	3.3	0.1	1.6
Atp6v1a					V			V
Atp6v1b2					V			V		V
Atp6v0a1					V			V		V
Atp6v0c					V					V
Atp6v0d2					V			V
Tcirg1					V			V	V
Atp6v1c1					V
Atp6v0e2						V				V
Atp6v0a2							V			V
Atp6v0d1										V
Atp6v1e1										V
Atp6v1f										V
Atp6v1g2										V
Atp6v1g1										V
Atp6v1d										V
Slc12a7										V
+ 5.6 Nervous system	2.9	1.4	2.1	2.8	4.3	5.1	1.5	3.1	1.2	9.1
+ 04724: Glutamatergic synapse	1.5	0	0.3	0.6	0.6	1.4	0.3	0.5	0	3
Adcy6	V					V				V
Slc38a3	V								V
Gls2	V			V					V
Glul	V					V				V
Grk2	V				V					V
Mapk3	V					V				V
Gnb2			V							V
Itpr1				V						V
Cacna1d					V					V
Adcy3					V					V
Adcy7					V
Slc38a1					V			V		V
Slc38a2					V				V
Gnao1					V					V
Gng2					V					V
Cacna1a					V
Mapk1					V			V		V
Homer3					V			V		V
Grik5						V				V
Slc1a3						V				V
Slc17a7						V				V
Gnas						V				V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Ppp3ca							V			V
Slc1a2									V
Adcy9									V
Gnaq									V
Homer2									V
Gria1										V
Gria3										V
Grin2d										V
Slc1a1										V
Cacna1c										V
Adcy4										V
Adcy5										V
Prkaca										V
Itpr3										V
Prkcb										V
Trpc1										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Gls										V
Grk3										V
Pla2g4a										V
Pld2										V
Shank3										V
+ 04727: GABAergic synapse	1	0	0.9	0.3	0.8	0.9	1.3	0.3	0.4	1.2
Adcy6	V					V				V
Glul	V					V				V
Gls2	V			V					V
Slc38a3	V								V
Slc6a12			V						V
Gnb2			V							V
Slc6a13					V	V	V		V	V
Adcy3					V					V
Adcy7					V
Cacna1a					V
Gnao1					V					V
Gng2					V					V
Cacna1d					V					V
Gabrr2					V		V
Slc38a1					V			V		V
Slc38a2					V				V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Plcl1						V				V
Src							V	V
Gabbr2									V
Adcy9									V
Abat									V
Gphn									V
Gabbr1										V
Adcy4										V
Adcy5										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Gabre										V
Gls										V
Prkaca										V
Gabarap										V
Gabarapl2										V
Cacna1c										V
Prkcb										V
Slc38a5										V
+ 04725: Cholinergic synapse	0.8	0	0.2	1.1	1.7	1.1	0.3	0.2	0	2.6
Adcy6	V					V				V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Gnb2			V							V
Itpr1				V						V
Creb3l2				V
Adcy3					V					V
Adcy7					V
Slc5a7					V
Cacna1a					V
Gnao1					V					V
Gng2					V					V
Kcnj2					V
Kcnj14					V
Mapk1					V			V		V
Creb3					V					V
Pik3cd					V
Akt1					V					V
Cacna1d					V					V
Pik3cg					V					V
Pik3r5					V			V		V
Fos					V					V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Pik3r2						V				V
Fyn						V				V
Kcnq4							V			V
Chrna4									V
Adcy9									V
Gnaq									V
Creb3l3									V
Kras									V
Adcy4										V
Adcy5										V
Prkaca										V
Gna11										V
Itpr3										V
Prkcb										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Atf4										V
Creb3l1										V
Camk2d										V
Camk2a										V
Camk2g										V
Pik3r3										V
Akt2										V
Akt3										V
Bcl2										V
Cacna1c										V
Map2k1										V
+ 04728: Dopaminergic synapse	0.6	0.4	1	0.9	2.2	0.5	0.2	0	0.1	4.4
Maob	V					V
Gsk3b	V									V
Mapk8	V
Ppp2r1b	V					V				V
Ddc		V							V
Comt		V				V			V
Arntl		V							V
Gnb2			V							V
Ppp1r1b			V
Mapk14			V	V	V				V
Itpr1				V						V
Creb3l2				V
Slc18a1					V				V
Gnal					V
Maoa					V					V
Cacna1a					V
Gnao1					V					V
Gng2					V					V
Akt1					V					V
Creb3					V					V
Mapk12					V					V
Fos					V					V
Arrb2					V				V	V
Ppp2r5b					V					V
Ppp2r5c					V			V		V
Ppp1cc					V					V
Ppp1ccb					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Cacna1d					V					V
Gnas						V				V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Ppp2r3a						V
Ppp3ca							V			V
Gnaq									V
Gsk3a									V
Creb3l3									V
Clock									V
Adcy5										V
Prkaca										V
Itpr3										V
Prkcb										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Akt2										V
Akt3										V
Atf4										V
Creb3l1										V
Mapk11										V
Mapk9										V
Ppp3cb										V
Ppp3cc										V
Camk2d										V
Camk2a										V
Camk2g										V
Ppp2ca										V
Ppp2cb										V
Ppp2r5a										V
Ppp2r2c										V
Ppp2r1a										V
Ppp2r2d										V
Ppp2r3c										V
Ppp2r2a										V
Ppp2r2b										V
Ppp1ca										V
Calml4										V
Cacna1c										V
Kif5a										V
Kif5c										V
Gria1										V
Gria3										V
+ 04726: Serotonergic synapse	0.9	1.1	1.1	0.9	0.1	1.8	0	0.3	2.6	0.4
Maob	V					V
Cyp2c50	V			V					V
Cyp2c39	V								V
Cyp2d26	V								V
Mapk3	V					V				V
Ddc		V							V
Cyp2c40		V							V
Cyp2c70		V	V						V
Cyp2c68		V							V
Cyp2c55		V							V
Gnb2			V							V
Cyp2c54			V						V
Itpr1				V						V
Kcnn2				V					V
Htr2b					V
Slc18a1					V				V
Cacna1a					V
Gnao1					V					V
Gng2					V					V
Maoa					V					V
Cacna1d					V					V
Mapk1					V			V		V
App					V					V
Gnas						V				V
Slc6a4						V				V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Rapgef3						V		V		V
Cyp2d22						V			V
Alox15						V				V
Alox5						V				V
Braf						V
Raf1						V		V		V
Gnaq									V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp2d10									V
Cyp2d9									V
Cyp2j5									V
Cyp2j6									V
Cyp2c23									V
Cyp2d11									V
Cyp2d40									V
Kras									V
Adcy5										V
Prkaca										V
Itpr3										V
Prkcb										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Pla2g4a										V
Cacna1c										V
Trpc1										V
Cyp2j9										V
Ptgs1										V
Dusp1										V
Araf										V
Map2k1										V
+ 04720: Long-term potentiation	0.5	0	0	1	1.3	0.8	0.2	1.6	0	3.5
Rps6ka1	V			V	V
Mapk3	V					V				V
Itpr1				V						V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Rps6ka2					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Mapk1					V			V		V
Rap1b					V					V
Rapgef3						V		V		V
Braf						V
Raf1						V		V		V
Ppp1r1a						V				V
Ppp3ca							V			V
Rap1a								V		V
Kras									V
Gnaq									V
Prkcb										V
Camk2d										V
Camk2a										V
Camk2g										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Calml4										V
Rps6ka3										V
Atf4										V
Grin2d										V
Prkaca										V
Cacna1c										V
Ppp1ca										V
Gria1										V
Map2k1										V
Araf										V
Itpr3										V
+ 04730: Long-term depression	0.6	0.3	0.6	0.5	0.7	1.8	0.3	0.7	0	1.9
Mapk3	V					V				V
Ppp2r1b	V					V				V
Igf1		V	V						V
Itpr1				V						V
Gna12					V
Gna13					V					V
Gnao1					V					V
Cacna1a					V
Mapk1					V			V		V
Lyn					V
Gnai1						V	V			V
Gnas						V				V
Gucy1a1						V				V
Braf						V
Raf1						V		V		V
Gnaq									V
Kras									V
Gna11										V
Gria1										V
Gria3										V
Pla2g4a										V
Gnai2										V
Prkcb										V
Igf1r										V
Gucy1b1										V
Map2k1										V
Araf										V
Ppp2ca										V
Ppp2cb										V
Ppp2r1a										V
Itpr3										V
+ 04723: Retrograde endocannabinoid signaling	0.6	0	1.3	1.1	0.3	5.7	1.2	0.2	0.1	3.5
Adcy6	V					V				V
Mapk3	V					V				V
Mapk8	V
Ndufs8	V						V			V
Ndufa11	V			V						V
Gnb2			V							V
Mapk14			V	V	V				V
Ndufs2			V	V	V	V	V	V	V	V
Ndufab1			V			V				V
Itpr1				V						V
Cacna1a					V
Cacna1d					V					V
Gabrr2					V		V
Gnao1					V					V
Gng2					V					V
Daglb					V
Mgll					V					V
Adcy3					V					V
Adcy7					V
Mapk1					V			V		V
Mapk12					V					V
Slc17a7						V				V
Gnai1						V	V			V
Gnb1						V				V
Gnb5						V				V
Abhd6						V			V
Ndufb11						V
ND3						V
Ndufa2						V				V
Ndufa4						V			V	V
Ndufv1						V
Ndufs1						V	V		V	V
Ndufs6						V			V	V
Ndufa1						V
Ndufa3						V
Ndufb9						V				V
Ndufc1						V				V
Ndufa12						V				V
Ndufa6						V			V	V
Ndufb8						V				V
Ndufa10						V				V
Ndufc2						V		V		V
Ndufb2						V
Ndufa5						V
Ndufb10						V				V
Ndufs3						V			V	V
Ndufs7						V	V			V
Ndufv3						V				V
Gnaq									V
Adcy9									V
Faah									V
Ndufa7									V	V
Itpr3										V
Prkcb										V
Cacna1c										V
Gabre										V
Cnr1										V
Gnai2										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Dagla										V
Gria1										V
Gria3										V
Adcy4										V
Adcy5										V
Prkaca										V
Napepld										V
Mapk11										V
Mapk9										V
Ndufb4c										V
Ndufb4b										V
Ndufb4										V
ND2										V
Ndufa4l2										V
Ndufs5										V
Ndufb5										V
Ndufb3										V
Ndufb7										V
Ndufv2										V
+ 04721: Synaptic vesicle cycle	0.1	0.5	1	0	2.7	0.9	0.5	2.7	0.3	2.6
Clta	V							V		V
Cltc		V								V
Ap2a1		V								V
Ap2b1			V
Slc6a12			V						V
Cacna1a					V
Stx2					V			V		V
Ap2m1					V				V
Dnm1					V					V
Slc18a1					V				V
Atp6v0b					V					V
Atp6v1a					V			V
Atp6v1b2					V			V		V
Atp6v0a1					V			V		V
Atp6v0c					V					V
Atp6v0d2					V			V
Tcirg1					V			V	V
Atp6v1c1					V
Slc6a13					V	V	V		V	V
Slc6a7					V
Vamp2						V				V
Slc17a7						V				V
Atp6v0e2						V				V
Slc6a4						V				V
Slc1a3						V				V
Atp6v0a2							V			V
Atp6v1h									V	V
Slc1a2									V
Stx1a										V
Cplx1										V
Rab3a										V
Snap25										V
Napa										V
Syt1										V
Cltb										V
Ap2s1										V
Dnm2										V
Stxbp1										V
Atp6v0d1										V
Atp6v1e1										V
Atp6v1f										V
Atp6v1g2										V
Atp6v1g1										V
Atp6v1d										V
Slc1a1										V
+ 04722: Neurotrophin signaling pathway	2.5	2.1	0.2	2.4	3	1.2	0.5	3.4	0.2	5.7
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Grb2	V	V			V					V
Mapk3	V					V				V
Rps6ka1	V			V	V
Rapgef1	V	V							V
Gsk3b	V									V
Mapk8	V
Jun	V									V
Rela		V						V	V
Kidins220		V							V
Irs1		V				V
Arhgdia		V								V
Irak2		V			V	V			V	V
Mapk14			V	V	V				V
Nfkbia				V				V		V
Irak1				V				V		V
Ywhae				V						V
Ntrk2					V		V	V		V
Pik3cd					V
Plcg2					V			V		V
Shc2					V					V
Prkcd					V			V		V
Akt1					V					V
Mapk1					V			V		V
Rps6ka2					V					V
Rap1b					V					V
Nfkbie					V
Matk					V
Mapk12					V					V
Arhgdib					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Psen2					V				V	V
Bax					V			V		V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Sh2b2						V				V
Sh2b1						V	V			V
Ngf							V
Rap1a								V		V
Abl1								V		V
Kras									V
Sos1									V
Map2k7									V	V
Irak4									V
Ntrk3										V
Ntf3										V
Pik3r3										V
Plcg1										V
Akt2										V
Akt3										V
Map2k1										V
Rps6ka3										V
Ptpn11										V
Bad										V
Nfkbib										V
Nfkb1										V
Atf4										V
Rps6ka5										V
Camk2d										V
Camk2a										V
Camk2g										V
Mapk9										V
Rhoa										V
Mapkapk2										V
Mapk11										V
Map2k5										V
Mapk7										V
Map3k3										V
Arhgdig										V
Sh2b3										V
Cdc42										V
Rac1										V
Maged1										V
Bex3										V
Irak3										V
Ikbkb										V
Bcl2										V
Calml4										V
+ 5.7 Sensory system	2	1	1.5	0.9	2.8	0.3	0.2	0.3	2	1.3
+ 04744: Phototransduction	0	0	0	0	0.7	0.2	0	0	0.1	0.1
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gnb1						V				V
Gnat1									V
Calml4										V
+ 04740: Olfactory transduction	0.9	0	0	0	2.8	0.1	0	0	0.1	1.6
Arrb1	V				V					V
Grk2	V				V					V
Gnal					V
Adcy3					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Pde1b					V					V
Arrb2					V				V	V
Pde2a					V					V
Gnb1						V				V
Ncald									V
Camk2d										V
Camk2a										V
Camk2g										V
Calml4										V
Prkaca										V
Grk3										V
Rgs2										V
+ 04742: Taste transduction	0.7	0	0.4	0	0	0	0	0	0	0
Scnn1a	V
P2ry1	V				V
Adcy6	V					V				V
P2ry4			V						V
Pde1b					V					V
Cacna1a					V
Kcnk5									V
Gabbr2									V
Itpr3										V
Cacna1c										V
Hcn4										V
Entpd2										V
Asic2										V
Gabbr1										V
Adcy4										V
Prkaca										V
+ 04750: Inflammatory mediator regulation of TRP channels	2.4	2	2.6	1.9	2	0.2	0.5	0.7	3.9	1
Pla2g6	V			V	V	V	V			V
Adcy6	V					V				V
Mapk8	V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Cyp2c50	V			V					V
Cyp2c39	V								V
Map2k6	V		V		V
Kng1	V								V
Cyp2c40		V							V
Cyp4a12b		V							V
Cyp2c70		V	V						V
Cyp4a12a		V							V
Cyp2c68		V							V
Cyp2c55		V							V
Igf1		V	V						V
Mapk14			V	V	V				V
Cyp2c54			V						V
Map2k3			V
Itpr1				V						V
P2ry2					V			V	V
Htr2b					V
Ptger4					V					V
Adcy3					V					V
Adcy7					V
Mapk12					V					V
Plcg2					V			V		V
Pik3cd					V
Prkcd					V			V		V
Ppp1cc					V					V
Ppp1ccb					V					V
Trpv2					V					V
Prkch					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gnas						V				V
Pik3r2						V				V
Ngf							V
Src							V	V
Il1rap									V
Il1b									V
Klk1b4									V
Gnaq									V
Adcy9									V
Cyp4a32									V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp2j5									V
Cyp2j6									V
Cyp4a10									V
Cyp4a14									V
Cyp2c23									V
Cyp4a31									V
Kng2									V
Ptger2										V
Trpv1										V
Asic2										V
Il1r1										V
Pla2g4a										V
Adcy4										V
Adcy5										V
Prkce										V
Prkaca										V
Camk2d										V
Camk2a										V
Camk2g										V
Mapk11										V
Mapk9										V
Plcg1										V
Pik3r3										V
Itpr3										V
Cyp2j9										V
Trpv4										V
Ppp1ca										V
F2rl1										V
Prkcb										V
Calml4										V
+ 5.8 Development and regeneration	3.4	0.4	1.6	1.2	6.3	2.5	2.3	5.9	1	8.7
+ 04360: Axon guidance	1.7	0.1	1.6	0.3	1.3	2.4	2.8	2.8	0.7	6.6
Mapk3	V					V				V
Robo1	V
Ngef	V		V						V
Unc5b	V									V
Sema4g	V	V							V
Sema5b	V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Gsk3b	V									V
Nrp1		V							V
Ephb4			V				V			V
Met			V			V			V
Cxcl12			V		V				V	V
Rhod			V						V
Cfl1				V	V					V
Cxcr4					V			V		V
Mapk1					V			V		V
Rac2					V					V
Itgb1					V					V
Rasa1					V			V
Ephb2					V					V
Ephb3					V
Sema7a					V					V
Plxnc1					V				V
Plxnb2					V			V	V
Plxna1					V					V
Plxna2					V					V
Sema3c					V					V
Sema4d					V			V
Limk1					V			V		V
Wnt5a					V					V
Pik3cd					V
Fes					V			V		V
Plcg2					V			V		V
Pard6b						V
Pard6g						V	V			V
Gnai1						V	V			V
Ptk2						V	V			V
Ephb6						V	V			V
Fyn						V				V
Rgs3						V	V			V
Sema5a						V				V
Smo						V				V
Ilk						V	V			V
Pik3r2						V				V
Pdk1						V				V
Rras						V				V
Raf1						V		V		V
Rgma						V				V
Ppp3ca							V			V
Efnb2							V			V
Sema6a							V			V
Src							V	V
Abl1								V		V
Sema3b								V		V
Pard3									V
Epha1									V
Epha2									V
Plxnb1									V
Sema4a									V
Srgap2									V
Kras									V
Ptch1									V
Wnt5b									V	V
Rnd1									V
Prkcz									V	V
Ssh3									V	V
Pard6a										V
Gnai2										V
Rac3										V
Rac1										V
Nfatc4										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Ntn4										V
Slit3										V
Cdc42										V
Rock1										V
Pak2										V
Rhoa										V
Nck1										V
Lrrc4c										V
Efnb1										V
Ephb1										V
Efna2										V
Efna4										V
Efna5										V
Ntn1										V
Plxna3										V
Plxna4										V
Sema3f										V
Sema3g										V
Sema6b										V
Sema4b										V
Sema4c										V
Srgap1										V
Nck2										V
Lrrc4										V
Bmp7										V
Bmpr2										V
Camk2d										V
Camk2a										V
Camk2g										V
Ryk										V
Trpc1										V
Trpc3										V
Pik3r3										V
Dpysl2										V
Limk2										V
Cdk5										V
Cfl2										V
Ssh1										V
Plcg1										V
Boc										V
Ptpn11										V
Ablim2										V
Myl12b										V
Myl9										V
+ 04380: Osteoclast differentiation	3.1	0.5	0.6	1.4	7.5	1.1	0.5	5.6	0.6	5.7
Ikbkg	V				V				V	V
Map2k6	V		V		V
Mapk8	V
Stat1	V				V				V	V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Jun	V									V
Blnk	V				V			V		V
Pparg	V					V				V
Grb2	V	V			V					V
Mapk3	V					V				V
Rela		V						V	V
Fcgr2b		V			V				V	V
Mapk14			V	V	V				V
Nfkbia				V				V		V
Sirpa				V	V			V		V
Csf1r					V
Tnfrsf11a					V			V		V
Csf1					V					V
Gab2					V					V
Mapk12					V					V
Nfatc1					V					V
Ifnar2					V					V
Pik3cd					V
Akt1					V					V
Fos					V					V
Fosl1					V			V
Junb					V
Fcgr1					V			V		V
Fcgr4					V				V
Tyrobp					V					V
Btk					V			V		V
Syk					V			V		V
Lcp2					V			V
Plcg2					V			V		V
Ctsk					V					V
Spi1					V			V		V
Tnf					V
Fhl2					V					V
Tgfb1					V					V
Nfkb2					V					V
Relb					V	V	V	V		V
Sqstm1					V	V			V
Mapk1					V			V		V
Cyba					V					V
Ncf1					V					V
Ncf2					V					V
Ncf4					V					V
Sirpb1c					V
Sirpb1a					V			V
Trem2					V			V		V
Fyn						V				V
Pik3r2						V				V
Ifngr1						V				V
Acp5						V	V	V		V
Ppp3ca							V			V
Fosl2								V		V
Ifnar1									V	V
Tyk2									V
Stat2									V
Il1a									V
Il1b									V
Map2k7									V	V
Lilra5									V
Traf2										V
Map3k14										V
Chuk										V
Ikbkb										V
Nfkb1										V
Tab1										V
Tab2										V
Map2k1										V
Mapk9										V
Mapk11										V
Pik3r3										V
Akt2										V
Akt3										V
Il1r1										V
Ifngr2										V
Jund										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Mitf										V
Tnfrsf1a										V
Tgfb2										V
Tgfbr2										V
Rac1										V
+ 5.9 Aging	3.5	2.4	1.5	2.5	1.2	4	2.5	0.4	2.6	4.9
+ 04211: Longevity regulating pathway	2.3	2.2	0.9	2.4	0.5	2.9	2.2	0.3	2.1	3.8
Akt1s1	V	V				V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Adcy6	V					V				V
Prkag2	V					V				V
Sirt1	V		V	V
Pparg	V					V				V
Igf1		V	V						V
Irs1		V				V
Rela		V						V	V
Rb1cc1		V								V
Atg13		V							V	V
Creb3l2				V
Eif4e2				V		V
Sesn1				V						V
Akt1					V					V
Pik3cd					V
Adcy3					V					V
Adcy7					V
Prkab1					V	V			V	V
Creb3					V					V
Sod2					V				V
Bax					V			V		V
Pik3r2						V				V
Eif4ebp1						V	V			V
Stk11						V				V
Adipoq						V	V			V
Mtor							V			V
Prkab2							V			V
Prkag3							V
Ehmt1							V
Rps6kb1									V
Kras									V
Adcy9									V
Prkaa2									V
Creb3l3									V
Ppargc1a									V
Ulk1									V	V
Camkk2									V
Cat									V
Atg101									V
Ehmt2									V	V
Foxo1										V
Rps6kb2										V
Akt2										V
Akt3										V
Pik3r3										V
Igf1r										V
Irs3										V
Irs2										V
Prkaca										V
Adcy4										V
Adcy5										V
Prkaa1										V
Prkag1										V
Atf4										V
Creb3l1										V
Tsc2										V
Rheb										V
Eif4e										V
Sesn2										V
Adipor1										V
Nfkb1										V
Appl1										V
+ 04213: Longevity regulating pathway - multiple species	2.6	1.3	1.2	1.1	1.2	2.8	1.3	0.2	1.5	3.1
Akt1s1	V	V				V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Adcy6	V					V				V
Prkag2	V					V				V
Sirt1	V		V	V
Igf1		V	V						V
Irs1		V				V
Akt1					V					V
Pik3cd					V
Adcy3					V					V
Adcy7					V
Prkab1					V	V			V	V
Sod2					V				V
Cryab					V					V
Hspa8					V			V	V	V
Pik3r2						V				V
Sod1						V
Clpb						V				V
Mtor							V			V
Prkab2							V			V
Prkag3							V
Rps6kb1									V
Kras									V
Foxa2									V
Adcy9									V
Prkaa2									V
Cat									V
Foxo1										V
Rps6kb2										V
Akt2										V
Akt3										V
Pik3r3										V
Igf1r										V
Irs3										V
Irs2										V
Prkaca										V
Adcy4										V
Adcy5										V
Prkaa1										V
Prkag1										V
Hspa2										V
Hspa1a										V
Hdac1										V
+ 5.10 Environmental adaptation	1.3	0.4	3.1	1.7	0.6	6.3	3.1	0.4	1.1	5.6
+ 04710: Circadian rhythm	0.5	0.6	2.6	0.8	0.2	2	2.7	0.5	1.6	2.3
Prkag2	V					V				V
Arntl		V							V
Per3			V
Cry1			V
Cry2			V
Nr1d1				V		V
Rbx1					V			V		V
Prkab1					V	V			V	V
Rorc						V				V
Skp1a						V	V		V	V
Fbxl3							V			V
Prkab2							V			V
Prkag3							V
Clock									V
Prkaa2									V
Bhlhe40									V
Rora										V
Per1										V
Csnk1d										V
Csnk1e										V
Cul1										V
Btrc										V
Prkaa1										V
Prkag1										V
+ 04713: Circadian entrainment	0.2	0	0.8	0.2	0.7	0.8	0.1	0.1	0	2.9
Mapk3	V					V				V
Adcy6	V					V				V
Gnb2			V							V
Per3			V
Itpr1				V						V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Gng2					V					V
Mapk1					V			V		V
Adcy3					V					V
Adcy7					V
Cacna1d					V					V
Gnao1					V					V
Fos					V					V
Gucy1a1						V				V
Gnb1						V				V
Gnb5						V				V
Gnas						V				V
Gnai1						V	V			V
Gnaq									V
Adcy9									V
Grin2d										V
Calml4										V
Camk2d										V
Camk2a										V
Camk2g										V
Gucy1b1										V
Prkcb										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Itpr3										V
Gria1										V
Gria3										V
Adcy4										V
Adcy5										V
Prkaca										V
Rasd1										V
Cacna1c										V
Gnai2										V
Rps6ka5										V
Per1										V
+ 04714: Thermogenesis	1.5	0.1	1.9	1.9	0.1	8.1	2.5	0	0.3	4.4
Fgf21	V			V	V
Adcy6	V					V				V
Pparg	V					V				V
Cpt1a	V				V				V
Rps6ka1	V			V	V
Akt1s1	V	V				V				V
Grb2	V	V			V					V
Prkag2	V					V				V
Cox4i1	V					V				V
Ndufs8	V						V			V
Ndufa11	V			V						V
Acsl4		V							V
Mapk14			V	V	V				V
Arid1b			V
Acsl1			V		V				V	V
Map2k3			V
Cox5a			V
Ndufs2			V	V	V	V	V	V	V	V
Ndufab1			V			V				V
Creb3l2				V
Acsl3				V					V
Atp5d				V		V
Creb3					V					V
Mapk12					V					V
Adcy3					V					V
Adcy7					V
Actb					V					V
Rps6ka2					V					V
Acsl5					V					V
Mgll					V					V
Prkab1					V	V			V	V
Cox6a2					V
Gnas						V				V
Adrb3						V				V
Lipe						V	V			V
Plin1						V				V
Pnpla2						V	V			V
Slc25a29						V				V
Ndufb11						V
Cox6a1						V				V
Cox6c						V				V
Cox7a2						V			V	V
Cox7c						V
COX2						V
COX3						V
ND3						V
Ndufa2						V				V
Ndufa4						V			V	V
Ndufv1						V
Uqcrq						V				V
Ndufs1						V	V		V	V
Ndufs6						V			V	V
Ndufa1						V
Ndufa3						V
Uqcr10						V
Ndufb9						V				V
Ndufc1						V				V
Ndufa12						V				V
Cyc1						V	V			V
Uqcr11						V
Uqcrfs1						V				V
Ndufaf3						V				V
Sdha						V				V
Uqcrc2						V			V
Ndufa6						V			V	V
Ndufb8						V				V
Ndufa10						V				V
Sdhb						V				V
Coa6						V	V
Ndufc2						V		V		V
Ndufb2						V
Ndufa5						V
Ndufb10						V				V
Ndufs3						V			V	V
Ndufs7						V	V			V
Ndufv3						V				V
Mtor							V			V
Prkab2							V			V
Prkag3							V
Cox7a1							V
Atp5g3							V
Creb3l3									V
Ppargc1a									V
Adcy9									V
Smarcc2									V
Rps6kb1									V
Sos1									V
Kras									V
Prkaa2									V
Ndufa7									V	V
Cox19									V
Creb3l1										V
Prkaca										V
Mapk11										V
Adcy4										V
Adcy5										V
Actg1										V
Smarcb1										V
Smarcc1										V
Actl6a										V
Smarce1										V
Smarcd3										V
Smarcd2										V
Arid1a										V
Cpt1c										V
Kdm1a										V
Rps6ka3										V
Tsc2										V
Rheb										V
Rps6kb2										V
Rps6-ps4										V
Rps6										V
Fgfr1										V
Cpt2										V
Cnr1										V
Prkaa1										V
Prkag1										V
Ndufb4c										V
Ndufb4b										V
Ndufb4										V
Cox6b1										V
Cox17										V
Cox8a										V
Cox8b										V
ND2										V
Cox7a2l										V
Uqcrc1										V
Cox18										V
Cox6b2										V
Ndufa4l2										V
Ndufs5										V
Ndufb5										V
Sdhc										V
Cox16										V
Cox20										V
Cox14										V
Ndufb3										V
Ndufb7										V
Ndufv2										V
Ndufaf7										V
Coa5										V
Ndufaf6										V
Cox4i2										V
Atp5c1										V
Atp5pb										V
+ 6. Human Diseases	11.7	8.7	6.1	7.4	13.6	10.5	5.3	11.8	6.8	20.6
+ 6.1 Cancer: overview	6.5	5.3	4.5	4.8	9.1	6.3	4.1	7.3	5.2	12.9
+ 05200: Pathways in cancer	2.4	1.6	2	1.1	4.8	2.5	2.5	2.5	1.3	7.9
Ctnnb1	V				V					V
Itga3	V					V	V			V
Fzd4	V		V							V
Fzd8	V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Gsk3b	V									V
Ikbkg	V				V				V	V
Mdm2	V	V			V					V
Stat1	V				V				V	V
Grb2	V	V			V					V
Mapk8	V
Jun	V									V
Pparg	V					V				V
Fas	V				V					V
Bid	V
Mapk3	V					V				V
Fgf21	V			V	V
Adcy6	V					V				V
Rasgrp2	V		V			V				V
Nfe2l2	V
Nqo1	V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Kng1	V								V
Cdh1		V							V
Ctnna1		V			V		V	V		V
Egfr		V							V
Igf1		V	V						V
Hsp90aa1		V					V		V
Hsp90b1		V							V
Stat3		V			V			V
Rela		V						V	V
Ccnd1		V			V				V
Elob		V								V
Gstp2		V				V			V	V
Gstp1		V				V			V
Dapk3		V				V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Txnrd1		V							V
Lamb1			V			V				V
Pten			V			V				V
Kit			V
Met			V			V			V
Arnt			V
Rxra			V	V					V
Fgf1			V						V
Gnb2			V							V
Cxcl12			V		V				V	V
Esr1			V					V
Nfkbia				V				V		V
Cul2				V
Mlh1				V		V
Zbtb16				V
Cdkn1a				V	V			V		V
Flt3l				V						V
Gsta1				V					V
Gstm4				V					V	V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Itgb1					V					V
Dvl1					V					V
Col4a1					V					V
Col4a2					V					V
Fn1					V	V	V	V	V
Itga6					V					V
Cbl					V
Pik3cd					V
Stat5b					V
Tpr					V				V
Tfg					V					V
Tpm3					V	V				V
Pdgfa					V					V
Rassf5					V				V
Nfkb2					V					V
Stk4					V
Ret					V					V
Ccdc6					V
Plcg2					V			V		V
Rac2					V					V
Fos					V					V
Vhl					V					V
Rbx1					V			V		V
Hif1a					V			V	V
Rad51					V
Tgfb1					V					V
Smad2					V					V
Smad4					V					V
Bax					V			V		V
Runx1					V			V		V
Rara					V			V	V
Spi1					V			V		V
E2f1					V					V
Ccne1					V
Cks2					V				V
Ccna2					V
Casp8					V					V
Birc5					V
Mmp2					V					V
Csf2ra					V					V
Csf1r					V
Mapk1					V			V		V
Akt1					V					V
F2r					V				V
Lpar5					V
Lpar3					V					V
Ptger4					V					V
Adcy3					V					V
Adcy7					V
Gng2					V					V
Gna12					V
Gna13					V					V
Arhgef1					V					V
Cxcr4					V			V		V
Notch2					V			V	V
Notch4					V		V			V
Hmox1					V			V		V
Gadd45a					V					V
Gadd45b					V			V		V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Pim1					V
Csf2rb					V					V
Csf2rb2					V			V		V
Ifnar2					V					V
Il13ra1					V				V
Il2rg					V					V
Il3ra					V					V
Il4ra					V					V
Il7r					V			V		V
Stat6					V					V
Wnt2b						V				V
Ptk2						V	V			V
Pik3r2						V				V
Ar						V				V
Cdkn1b						V	V			V
Braf						V
Raf1						V		V		V
Smo						V				V
Egln2						V				V
Jup						V	V			V
Cks1b						V				V
Bmp4						V				V
Vegfb						V	V			V
Mmp9						V				V
Fgf10						V				V
Gnas						V				V
Gnb1						V				V
Gnb5						V				V
Gnai1						V	V			V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Gadd45g						V				V
Skp1a						V	V		V	V
Ifngr1						V				V
Agt						V	V
Stat5a							V			V
Igf2							V			V
Mtor							V			V
Ncoa4							V			V
Dapk2							V
Agtr1a							V
Dll1							V
Heyl							V			V
Lamc2								V
Abl1								V		V
Bcl2l1								V
Wnt2									V
Wnt5b									V	V
Fgfr3									V
Fgfr4									V
Tgfa									V
Hsp90ab1									V	V
Sos1									V
Kras									V
Ptch1									V
Egln3									V
Rxrb									V	V
Pml									V
Bmp2									V
Xiap									V
Traf4									V
Adcy9									V
Gnaq									V
Rasgrp3									V
Flt4									V
Gstm6									V
Gsto1									V
Gstm7									V
Rps6kb1									V
Ifnar1									V	V
Il12rb1									V
Il15ra									V	V
Il6ra									V
Stat2									V
F2									V
Kng2									V
Casp9										V
Wnt9a										V
Wnt6										V
Dvl2										V
Col4a4										V
Col4a5										V
Lama2										V
Lama4										V
Lamb2										V
Lamc1										V
Col4a6										V
Fzd1										V
Fzd6										V
Fzd2										V
Appl1										V
Pik3r3										V
Erbb2										V
Igf1r										V
Fgfr1										V
Axin2										V
Chuk										V
Ikbkb										V
Bad										V
Araf										V
Map2k1										V
Rassf1										V
Nfkb1										V
Plcg1										V
Ralgds										V
Rala										V
Ralb										V
Rhoa										V
Rac3										V
Rac1										V
Ralbp1										V
Pld2										V
Mapk9										V
Cdc42										V
Myc										V
Tcf7l1										V
Tcf7l2										V
Prkcb										V
Sufu										V
Egln1										V
Eloc										V
Msh2										V
Tgfb2										V
Tgfb3										V
Tgfbr2										V
Ctbp1										V
Ctbp2										V
Hdac1										V
Rxrg										V
Cebpa										V
Mitf										V
Max										V
Zbtb17										V
Ccnd2										V
Ccnd3										V
Cdk4										V
Rb1										V
Cdkn2b										V
Fadd										V
Gli1										V
Ptch2										V
Nos2										V
Bcl2										V
Birc3										V
Traf1										V
Traf2										V
Vegfd										V
Pgf										V
Vegfc										V
Slc2a1										V
Dapk1										V
Ppard										V
Foxo1										V
Akt2										V
Akt3										V
Gli2										V
Gli3										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Lpar1										V
Lpar6										V
Lpar4										V
Ptger2										V
Ednra										V
Ednrb										V
Adcy4										V
Adcy5										V
Prkaca										V
Gnb4										V
Gng10										V
Gng12										V
Gng3										V
Gng4										V
Gngt2										V
Gng11										V
Plekhg5										V
Rock1										V
Gna11										V
Rasgrp4										V
Gnai2										V
Kif7										V
Jag1										V
Jag2										V
Notch1										V
Notch3										V
Dll4										V
Hey1										V
Hey2										V
Gstm2										V
Bak1										V
Ddb2										V
Ncoa1										V
Rps6kb2										V
Rps6ka5										V
Calml4										V
Camk2d										V
Camk2a										V
Camk2g										V
Elk1										V
Cul1										V
Pmaip1										V
Casp7										V
Apaf1										V
Il4										V
Il7										V
Epor										V
Ifngr2										V
Il2ra										V
Il2rb										V
Edn1										V
+ 05202: Transcriptional misregulation in cancer	0.2	2.6	2	1.7	2.3	1.1	1.6	3.6	0.7	4
Pparg	V					V				V
Mdm2	V	V			V					V
Dusp6	V			V
Hpgd	V					V
Igf1		V	V						V
H3c14		V
H3c7		V
H3c3		V
H3c4		V
H3c2		V
H3c6		V
H3c13		V
H3c15		V
Rela		V						V	V
Tfe3			V		V			V
Met			V			V			V
Rxra			V	V					V
Ncor1			V
Hhex			V		V				V
Ddit3				V	V					V
Cdkn1a				V	V			V		V
Slc45a3				V					V	V
Zbtb16				V
Fli1					V					V
Pdgfa					V					V
Plau					V					V
Mmp3					V					V
Runx1					V			V		V
Rara					V			V	V
Ccna2					V
Bcl2a1d					V					V
Spi1					V			V		V
Itgam					V					V
Fcgr1					V			V		V
Rel					V
Smad1					V				V
Hmga2					V			V
Bmp2k					V					V
Men1					V
Cdk9					V				V
Dot1l					V			V		V
Csf1r					V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Ewsr1						V			V	V
Aspscr1						V			V	V
Tspan7						V				V
Mmp9						V				V
Jup						V	V			V
Supt3						V	V			V
Cdkn1b						V	V			V
Ptk2						V	V			V
Meis1						V				V
Cdkn2c						V	V			V
Gadd45g						V				V
Zeb1							V
Lmo2							V			V
Fut8							V			V
Atf1								V
Ss18								V	V	V
Cd14								V		V
Bcl2l1								V
Id2									V
Cebpb									V
Rxrb									V	V
Pml									V
Cebpe									V
Etv6									V
Sin3a									V	V
Klf3									V
Bcl6									V	V
Erg										V
Etv1										V
Fus										V
Foxo1										V
Myc										V
Il2rb										V
Mlf1										V
Nupr1										V
Igfbp3										V
Tgfbr2										V
Prcc										V
Etv5										V
Elk4										V
Rxrg										V
Bcl2a1b										V
Cebpa										V
Birc3										V
Traf1										V
Cd86										V
Cd40										V
Pbx1										V
Aff1										V
Jmjd1c										V
Igf1r										V
Cdk14										V
Maf										V
Ccnd2										V
Itgb7										V
Max										V
Zbtb17										V
Bmi1										V
Mllt3										V
Six1										V
Gria3										V
H3f3a										V
H3f3b										V
Plat										V
Hdac1										V
Nfkb1										V
Ldb1										V
Lyl1										V
Bak1										V
Ddb2										V
Mitf										V
+ 05206: MicroRNAs in cancer	2.2	2.3	1.3	2.8	5	1	0.5	4.3	0.1	5
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Sirt1	V		V	V
Vim	V			V	V			V		V
Gls2	V			V					V
Abcb1a	V					V				V
Mapk3	V					V				V
Grb2	V	V			V					V
Mdm2	V	V			V					V
Bmf	V									V
Tpm1		V			V			V		V
Ccnd1		V			V				V
Foxp1		V
Egfr		V							V
Stat3		V			V			V
Irs1		V				V
Itga5		V			V					V
Pten			V			V				V
Met			V			V			V
Ezh2			V							V
Dnmt3a				V	V			V	V	V
Pdcd4				V
Slc45a3				V					V	V
Cdkn1a				V	V			V		V
Hmga2					V			V
Mcl1					V					V
Fscn1					V					V
St14					V
Stmn1					V					V
Ccne1					V
Pim1					V
Zeb2					V	V		V		V
Slc7a1					V					V
Ccng1					V					V
Hmox1					V			V		V
Pik3cd					V
Hnrnpk					V			V		V
Notch2					V			V	V
Notch4					V		V			V
E2f1					V					V
Cd44					V			V
Marcks					V					V
Cdca5					V
Kif23					V
Sox4					V					V
Tnc					V
Plau					V					V
Brca1					V
Thbs1					V					V
Mapk1					V			V		V
Plcg2					V			V		V
Pdgfa					V					V
Cdkn1b						V	V			V
Mmp9						V				V
Pik3r2						V				V
Raf1						V		V		V
Zeb1							V
Mtor							V			V
Abl1								V		V
Ube2i								V		V
Bcl2l2									V	V
Kras									V
Erbb3									V
Rdx									V
Fgfr3									V
Sos1									V
Cdc25b										V
Cyp1b1										V
Rassf1										V
Ddit4										V
Ccnd2										V
Hdac5										V
Tgfb2										V
Ezr										V
Timp3										V
Erbb2										V
Spry2										V
Bcl2										V
Myc										V
Pik3r3										V
Mapk7										V
Irs2										V
Notch1										V
Notch3										V
Bmi1										V
Rock1										V
Bak1										V
Prkce										V
Bmpr2										V
Hdac1										V
Gls										V
Zfpm2										V
Dicer1										V
Rhoa										V
Abcb1b										V
Abcc1										V
Nfkb1										V
Ikbkb										V
Efna2										V
Efna4										V
Efna5										V
Prkcb										V
Rps6ka5										V
Plcg1										V
Map2k1										V
+ 05205: Proteoglycans in cancer	2	1.4	1.4	1.6	5.8	1.5	1.5	4	0.8	6.5
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Grb2	V	V			V					V
Mdm2	V	V			V					V
Ctnnb1	V				V					V
Dcn	V					V				V
Fas	V				V					V
Fzd4	V		V							V
Fzd8	V
Gpc1	V				V					V
Stat3		V			V			V
Ccnd1		V			V				V
Igf1		V	V						V
Sdc4		V							V
Itga5		V			V					V
Egfr		V							V
Esr1			V					V
Met			V			V			V
Mapk14			V	V	V				V
Itpr1				V						V
Cttn				V		V			V	V
Pdcd4				V
Cdkn1a				V	V			V		V
Cd44					V			V
Pik3cd					V
Akt1					V					V
Ppp1cc					V					V
Ppp1ccb					V					V
Actb					V					V
Iqgap1					V			V		V
Mapk1					V			V		V
Hcls1					V					V
Vav1					V			V
Vav3					V					V
Arhgef1					V					V
Smad2					V					V
Plau					V					V
Plaur					V			V		V
Tgfb1					V					V
Cbl					V
Thbs1					V					V
Mmp2					V					V
Hif1a					V			V	V
Tnf					V
Lum					V			V		V
Sdc1					V				V
Hpse					V
Col1a1					V					V
Itgb1					V					V
Msn					V					V
Fn1					V	V	V	V	V
Plcg2					V			V		V
Ctsl					V			V	V
Mapk12					V					V
Hbegf					V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Cd63					V			V		V
Cav1					V		V			V
Pik3r2						V				V
Rras						V				V
Braf						V
Raf1						V		V		V
Mmp9						V				V
Ptk2						V	V			V
Gpc3						V		V		V
Smo						V				V
Twist2						V				V
Wnt2b						V				V
Plce1							V			V
Src							V	V
Mtor							V			V
Itgb5							V			V
Igf2							V			V
Ank3									V
Kras									V
Erbb3									V
Rps6kb1									V
Sdc2									V
Rdx									V
Sos1									V
Ptch1									V
Ptpn6									V	V
Vtn									V
Wnt2									V
Wnt5b									V	V
Tiam1										V
Erbb2										V
Rhoa										V
Rock1										V
Pik3r3										V
Akt2										V
Akt3										V
Ppp1r12a										V
Ppp1ca										V
Ppp1r12c										V
Ppp1r12b										V
Itpr3										V
Camk2d										V
Camk2a										V
Camk2g										V
Flnc										V
Rac1										V
Cdc42										V
Actg1										V
Elk1										V
Mras										V
Rras2										V
Araf										V
Map2k1										V
Drosha										V
Nudt16l1										V
Tlr4										V
Myc										V
Timp3										V
Igf1r										V
Rps6kb2										V
Rps6-ps4										V
Rps6										V
Tgfb2										V
Col1a2										V
Fzd1										V
Fzd6										V
Fzd2										V
Ezr										V
Fgf2										V
Fgfr1										V
Ptpn11										V
Plcg1										V
Prkcb										V
Prkaca										V
Mapk11										V
Hspb2										V
Twist1										V
Wnt9a										V
Wnt6										V
Cav2										V
+ 05204: Chemical carcinogenesis	3	5.6	2	1.8	0	4.5	3	0.3	9.8	0
Cyp2c50	V			V					V
Cyp2c39	V								V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Gstk1	V					V
Hsd11b1	V					V			V
Kyat3	V					V			V	V
Kyat1	V							V	V
Cyp1a2		V							V
Cyp2c40		V							V
Cyp2c70		V	V						V
Cyp2c68		V							V
Cyp2c55		V							V
Ugt2b38		V							V
Ugt2b37		V							V
Ugt1a9		V							V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Ephx1		V			V				V
Cyp3a11		V		V					V
Cyp2c54			V						V
Ugt2b34			V						V
Arnt			V
Gsta1				V					V
Gstm4				V					V	V
Aldh3b1					V
Hpgds					V			V		V
Cyp2e1						V	V			V
Ugt1a7c						V				V
Ugt1a5						V			V
Adh1						V	V		V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Sult1a1						V	V			V
Ugt1a1							V		V
Adh5							V		V
Cyp2c29									V
Cyp2c37									V
Cyp2c38									V
Cyp2c23									V
Ugt1a2									V
Ugt2b5									V
Ugt2b36									V
Ugt2b35									V
Ugt2b1									V
Ugt2a3									V
Adh4									V
Gstm6									V
Gsto1									V
Gstm7									V
Nat2									V
Cyp3a13									V
Cyp3a25									V
Ugt1a6b										V
Aldh1a3										V
Aldh3b2										V
Gstm2										V
Cyp1b1										V
+ 05203: Viral carcinogenesis	1.5	0.9	0	1.8	3.1	2.6	0.4	1.9	0.2	3.4
Dlg1	V						V
Psmc1	V
Jun	V									V
Ikbkg	V				V				V	V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Vac14	V				V					V
Mdm2	V	V			V					V
Grb2	V	V			V					V
Stat3		V			V			V
Rela		V						V	V
Ccnd1		V			V				V
Gtf2b		V
Ddx3x		V
Gtf2a2			V						V	V
Creb3l2				V
Mrps18b				V
Ywhae				V						V
Cdkn1a				V	V			V		V
Nfkbia				V				V		V
Irf7				V
Casp8					V					V
Bax					V			V		V
Mapk1					V			V		V
Creb3					V					V
Stat5b					V
Pik3cd					V
Nfkb2					V					V
Rel					V
Egr2					V					V
Egr3					V
Lyn					V
Syk					V			V		V
Ccna2					V
Ccne1					V
Ywhaq					V					V
Atp6v0d2					V			V
Hdac6					V					V
Gsn					V	V	V			V
Actn1					V					V
Actn4					V	V				V
Cdc20					V
H2-K1					V				V	V
H2-M2					V
H2-Q4					V					V
Hnrnpk					V			V		V
Cdk1					V
H2bc6					V
H2bc8					V
H2bc4					V
Pik3r2						V				V
Srf						V				V
Ubr4						V				V
Ywhag						V			V	V
Cdkn1b						V	V			V
H2-Q10						V			V
Hist1h4m						V				V
H4c3						V				V
H4c4						V				V
H4c6						V				V
H4c9						V				V
H4c11						V				V
H4c12						V				V
Hist1h4n						V				V
H4f16						V				V
H4c1						V				V
H4c2						V				V
H4c8						V				V
H4c14						V				V
Src							V	V
Stat5a							V			V
H2-D1								V		V
Irf3									V
Tbpl1									V	V
Creb3l3									V
Usp7									V
Hpn									V
Kras									V
Gtf2e1									V
Snd1									V
Dnaja3									V
Hdac11									V
C3									V	V
H2-Q7									V
H2-T23									V
Scrib										V
Bak1										V
Rb1										V
Rbl1										V
Chd4										V
Bad										V
Pmaip1										V
Traf1										V
Traf2										V
Ddb1										V
Atf4										V
Creb3l1										V
Pik3r3										V
Nfkb1										V
Cdk4										V
Cdkn2b										V
Ranbp1										V
Ccnd2										V
Ccnd3										V
Vdac3										V
Ywhah										V
Ywhaz										V
Ywhab										V
Snw1										V
Gtf2h1										V
Gtf2h4										V
Gtf2h3										V
Atp6v0d1										V
Pkm										V
Hdac5										V
Hdac10										V
Hdac1										V
Rasa2										V
Cdc42										V
Rac1										V
Rhoa										V
Mapkapk2										V
H2-M3										V
H2-T22										V
Prkaca										V
Sp100										V
H2bc21										V
+ 05230: Central carbon metabolism in cancer	1.9	0.2	2.4	1.6	1.3	3.6	1.7	1.5	1	3.8
Gck	V			V					V
Gls2	V			V					V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Egfr		V							V
Sirt3			V			V	V
Kit			V
Met			V			V			V
Pten			V			V				V
Slc16a3					V					V
Hif1a					V			V	V
Ldha					V				V
Ret					V					V
Mapk1					V			V		V
Pik3cd					V
Akt1					V					V
Hk3					V			V
G6pdx					V					V
Pdha1						V				V
Pdhb						V				V
Ldhb						V	V			V
Pdk1						V				V
Raf1						V		V		V
Pik3r2						V				V
Slc1a5						V	V			V
Mtor							V			V
Slc2a2									V
Fgfr3									V
Kras									V
Slc2a1										V
Gls										V
Myc										V
Pkm										V
Erbb2										V
Fgfr1										V
Ntrk3										V
Map2k1										V
Pik3r3										V
Akt2										V
Akt3										V
Hk1										V
Hk2										V
Pfkl										V
Pfkm										V
Pfkp										V
Sco2										V
Slc7a5										V
+ 05231: Choline metabolism in cancer	3.7	0.3	0.3	0.2	1.7	1.1	0.7	1.4	0.6	3.8
Mapk8	V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Grb2	V	V			V					V
Slc22a3	V								V	V
Chkb	V							V		V
Chpt1	V					V				V
Pcyt1a	V								V
Lypla1	V								V
Jun	V									V
Egfr		V							V
Gpcpd1			V						V
Mapk1					V			V		V
Akt1					V					V
Pik3cd					V
Pdgfa					V					V
Pdgfc					V					V
Slc22a4					V		V			V
Slc5a7					V
Dgkz					V			V		V
Pip5k1c					V				V
Was					V					V
Rac2					V					V
Fos					V					V
Hif1a					V			V	V
Raf1						V		V		V
Pik3r2						V				V
Slc44a3						V				V
Eif4ebp1						V	V			V
Mtor							V			V
Sos1									V
Kras									V
Slc22a1									V
Rps6kb1									V
Mapk9										V
Map2k1										V
Akt2										V
Akt3										V
Pik3r3										V
Pdgfd										V
Slc44a1										V
Slc22a21										V
Slc44a2										V
Slc44a4										V
Plcg1										V
Pla2g4a										V
Ralgds										V
Pld2										V
Tsc2										V
Rheb										V
Rps6kb2										V
Dgka										V
Pip5k1b										V
Rac3										V
Rac1										V
Wasf2										V
Wasf1										V
Plpp1										V
Plpp3										V
Prkcb										V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	2.4	0.9	2.1	1.9	3.2	1	0.4	2.5	1.2	4.2
Ikbkg	V				V				V	V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Jun	V									V
Mapk3	V					V				V
Stat1	V				V				V	V
Map2k6	V		V		V
Rela		V						V	V
Egfr		V							V
Stat3		V			V			V
Map2k3			V
Mapk14			V	V	V				V
Pten			V			V				V
Nfkbia				V				V		V
Csnk2b				V				V	V
Nfkbie					V
Akt1					V					V
Pik3cd					V
Fos					V					V
Nfatc1					V					V
Mapk1					V			V		V
Tlr9					V					V
Cd274					V					V
Mapk12					V					V
Csnk2a1					V				V
Csnk2a2					V
Hif1a					V			V	V
Ticam2					V					V
Pik3r2						V				V
Raf1						V		V		V
Ifngr1						V				V
Ppp3ca							V			V
Mtor							V			V
Kras									V
Ptpn6									V	V
Rps6kb1									V
Tirap									V
Nfkbib										V
Nfkb1										V
Chuk										V
Ikbkb										V
Akt2										V
Akt3										V
Pik3r3										V
Ppp3cb										V
Ppp3cc										V
Ppp3r1										V
Plcg1										V
Cd247										V
Cd3g										V
Ptpn11										V
Map2k1										V
Ifngr2										V
Tlr4										V
Batf3										V
Batf										V
Map3k3										V
Mapk11										V
Rps6kb2										V
Lat										V
+ 6.2 Cancer: specific types	8.6	6.5	3.9	5.7	10.9	7.3	2.4	9.6	2.3	16.9
+ 05210: Colorectal cancer	2.8	0.9	0	1.4	2.6	1.3	0.1	1.6	0.1	5.3
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk8	V
Mapk3	V					V				V
Jun	V									V
Gsk3b	V									V
Ctnnb1	V				V					V
Grb2	V	V			V					V
Ccnd1		V			V				V
Egfr		V							V
Mlh1				V		V
Cdkn1a				V	V			V		V
Tgfb1					V					V
Pik3cd					V
Smad2					V					V
Smad4					V					V
Rac2					V					V
Birc5					V
Mapk1					V			V		V
Fos					V					V
Akt1					V					V
Bax					V			V		V
Gadd45a					V					V
Gadd45b					V			V		V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Gadd45g						V				V
Mtor							V			V
Kras									V
Rps6kb1									V
Sos1									V
Tgfa									V
Tgfb2										V
Tgfb3										V
Pik3r3										V
Casp9										V
Appl1										V
Msh2										V
Araf										V
Mapk9										V
Axin2										V
Ralgds										V
Rhoa										V
Rac3										V
Rac1										V
Myc										V
Map2k1										V
Bcl2										V
Tcf7l1										V
Tcf7l2										V
Akt2										V
Akt3										V
Bad										V
Tgfbr2										V
Bak1										V
Ddb2										V
Pmaip1										V
Rala										V
Ralb										V
Rps6kb2										V
+ 05212: Pancreatic cancer	2.2	1.5	0	0.9	3.3	1.2	0.2	3.2	0.5	5.9
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ikbkg	V				V				V	V
Mapk3	V					V				V
Mapk8	V
Stat1	V				V				V	V
Rela		V						V	V
Stat3		V			V			V
Egfr		V							V
Ccnd1		V			V				V
Cdkn1a				V	V			V		V
Pik3cd					V
Akt1					V					V
Rac2					V					V
Mapk1					V			V		V
E2f1					V					V
Tgfb1					V					V
Smad2					V					V
Smad4					V					V
Rad51					V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Gadd45g						V				V
Mtor							V			V
Bcl2l1								V
Kras									V
Tgfa									V
Rps6kb1									V
Erbb2										V
Pik3r3										V
Akt2										V
Akt3										V
Rac3										V
Rac1										V
Chuk										V
Ikbkb										V
Nfkb1										V
Bad										V
Araf										V
Casp9										V
Map2k1										V
Ralgds										V
Rala										V
Ralb										V
Ralbp1										V
Pld2										V
Mapk9										V
Cdc42										V
Cdk4										V
Rb1										V
Tgfb2										V
Tgfb3										V
Tgfbr2										V
Rps6kb2										V
Bak1										V
Ddb2										V
+ 05225: Hepatocellular carcinoma	3.1	2.1	1.2	1	1.7	3	0.8	1.6	1.8	4.2
Mapk3	V					V				V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ctnnb1	V				V					V
Gsk3b	V									V
Fzd4	V		V							V
Fzd8	V
Nfe2l2	V
Nqo1	V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Egfr		V							V
Ccnd1		V			V				V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Txnrd1		V							V
Pten			V			V				V
Met			V			V			V
Arid1b			V
Cdkn1a				V	V			V		V
Gsta1				V					V
Gstm4				V					V	V
Mapk1					V			V		V
Shc2					V					V
Pik3cd					V
Akt1					V					V
Dvl1					V					V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
E2f1					V					V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Plcg2					V			V		V
Tgfb1					V					V
Smad2					V					V
Smad4					V					V
Hmox1					V			V		V
Actb					V					V
Braf						V
Raf1						V		V		V
Pik3r2						V				V
Wnt2b						V				V
Gadd45g						V				V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Mtor							V			V
Igf2							V			V
Bcl2l1								V
Kras									V
Sos1									V
Rps6kb1									V
Wnt2									V
Wnt5b									V	V
Tgfa									V
Smarcc2									V
Gstm6									V
Gsto1									V
Gstm7									V
Araf										V
Map2k1										V
Rps6kb2										V
Igf1r										V
Pik3r3										V
Akt2										V
Akt3										V
Myc										V
Tcf7l1										V
Tcf7l2										V
Axin2										V
Dvl2										V
Fzd1										V
Fzd6										V
Fzd2										V
Wnt9a										V
Wnt6										V
Rb1										V
Bak1										V
Ddb2										V
Plcg1										V
Prkcb										V
Elk1										V
Tgfb2										V
Tgfb3										V
Tgfbr2										V
Arid1a										V
Smarcb1										V
Smarcc1										V
Gstm2										V
Bad										V
Cdk4										V
Actg1										V
Phf10										V
Actl6a										V
Smarcd3										V
Smarcd2										V
Smarce1										V
Brd7										V
+ 05226: Gastric cancer	2.4	1	1.4	1.7	2.2	1.7	0.6	1.2	0.1	3.5
Mapk3	V					V				V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ctnnb1	V				V					V
Gsk3b	V									V
Fzd4	V		V							V
Fzd8	V
Fgf21	V			V	V
Abcb1a	V					V				V
Ccnd1		V			V				V
Cdh1		V							V
Ctnna1		V			V		V	V		V
Egfr		V							V
Met			V			V			V
Fgf1			V						V
Rxra			V	V					V
Cdkn1a				V	V			V		V
Mlh1				V		V
Mapk1					V			V		V
Shc2					V					V
Pik3cd					V
Akt1					V					V
Dvl1					V					V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Tgfb1					V					V
Smad2					V					V
Smad4					V					V
Ccne1					V
E2f1					V					V
Braf						V
Raf1						V		V		V
Pik3r2						V				V
Wnt2b						V				V
Gadd45g						V				V
Jup						V	V			V
Cdkn1b						V	V			V
Fgf10						V				V
Mtor							V			V
Kras									V
Sos1									V
Rps6kb1									V
Wnt2									V
Wnt5b									V	V
Rxrb									V	V
Araf										V
Map2k1										V
Rps6kb2										V
Pik3r3										V
Akt2										V
Akt3										V
Myc										V
Tcf7l1										V
Tcf7l2										V
Axin2										V
Dvl2										V
Fzd1										V
Fzd6										V
Fzd2										V
Wnt9a										V
Wnt6										V
Bak1										V
Ddb2										V
Tgfb2										V
Tgfb3										V
Tgfbr2										V
Erbb2										V
Rb1										V
Bcl2										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Cdkn2b										V
Rxrg										V
Abcb1b										V
+ 05214: Glioma	1.8	2	1.1	0.9	3.4	1.6	0.2	2.3	0.2	4.2
Grb2	V	V			V					V
Mapk3	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mdm2	V	V			V					V
Igf1		V	V						V
Egfr		V							V
Ccnd1		V			V				V
Pten			V			V				V
Cdkn1a				V	V			V		V
Pdgfa					V					V
Calm1					V					V
Calm2					V					V
Calm3					V					V
Shc2					V					V
Mapk1					V			V		V
Pik3cd					V
Akt1					V					V
E2f1					V					V
Plcg2					V			V		V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Braf						V
Raf1						V		V		V
Pik3r2						V				V
Gadd45g						V				V
Mtor							V			V
Tgfa									V
Sos1									V
Kras									V
Igf1r										V
Calml4										V
Camk2d										V
Camk2a										V
Camk2g										V
Camk1										V
Prkcb										V
Araf										V
Map2k1										V
Pik3r3										V
Akt2										V
Akt3										V
Cdk4										V
Rb1										V
Plcg1										V
Bak1										V
Ddb2										V
+ 05216: Thyroid cancer	1.6	1.2	0.8	1.5	3.9	1.7	0.5	2.3	1.3	3.4
Pparg	V					V				V
Mapk3	V					V				V
Ctnnb1	V				V					V
Cdh1		V							V
Ccnd1		V			V				V
Rxra			V	V					V
Cdkn1a				V	V			V		V
Mapk1					V			V		V
Ret					V					V
Ccdc6					V
Tpr					V				V
Tfg					V					V
Tpm3					V	V				V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Braf						V
Gadd45g						V				V
Ncoa4							V			V
Kras									V
Rxrb									V	V
Map2k1										V
Rxrg										V
Myc										V
Tcf7l1										V
Tcf7l2										V
Bak1										V
Ddb2										V
+ 05221: Acute myeloid leukemia	2.3	1.6	0.5	1.6	3.6	1.8	1.6	3.8	0.9	3.5
Ikbkg	V				V				V	V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Dusp6	V			V
Rela		V						V	V
Stat3		V			V			V
Ccnd1		V			V				V
Kit			V
Zbtb16				V
Rara					V			V	V
Spi1					V			V		V
Runx1					V			V		V
Stat5b					V
Ccna2					V
Pim1					V
Akt1					V					V
Pik3cd					V
Mapk1					V			V		V
Bcl2a1d					V					V
Itgam					V					V
Fcgr1					V			V		V
Csf1r					V
Jup						V	V			V
Eif4ebp1						V	V			V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Stat5a							V			V
Mtor							V			V
Cd14								V		V
Kras									V
Pml									V
Rps6kb1									V
Sos1									V
Cebpe									V
Cebpa										V
Ppard										V
Myc										V
Nfkb1										V
Tcf7l1										V
Tcf7l2										V
Chuk										V
Ikbkb										V
Bad										V
Rps6kb2										V
Akt2										V
Akt3										V
Pik3r3										V
Map2k1										V
Araf										V
Bcl2a1b										V
+ 05220: Chronic myeloid leukemia	2.2	1.5	0	1.5	3.9	1.6	0.5	4	0.1	5.4
Mdm2	V	V			V					V
Ikbkg	V				V				V	V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Rela		V						V	V
Ccnd1		V			V				V
Nfkbia				V				V		V
Cdkn1a				V	V			V		V
Runx1					V			V		V
Tgfb1					V					V
Stat5b					V
Smad4					V					V
Shc2					V					V
Gab2					V					V
Cbl					V
E2f1					V					V
Akt1					V					V
Pik3cd					V
Mapk1					V			V		V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Cdkn1b						V	V			V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Gadd45g						V				V
Stat5a							V			V
Bcl2l1								V
Abl1								V		V
Sos1									V
Kras									V
Ptpn11										V
Tgfb2										V
Tgfb3										V
Hdac1										V
Ctbp1										V
Ctbp2										V
Myc										V
Tgfbr2										V
Nfkb1										V
Chuk										V
Ikbkb										V
Bad										V
Rb1										V
Cdk4										V
Akt2										V
Akt3										V
Pik3r3										V
Map2k1										V
Araf										V
Bak1										V
Ddb2										V
+ 05217: Basal cell carcinoma	1.6	0	0.5	0.5	1.5	0.6	0	1.1	0.1	3.5
Fzd4	V		V							V
Fzd8	V
Ctnnb1	V				V					V
Gsk3b	V									V
Cdkn1a				V	V			V		V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
Dvl1					V					V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Bmp4						V				V
Wnt2b						V				V
Smo						V				V
Gadd45g						V				V
Ptch1									V
Bmp2									V
Wnt2									V
Wnt5b									V	V
Kif7										V
Gli1										V
Ptch2										V
Wnt9a										V
Wnt6										V
Sufu										V
Axin2										V
Dvl2										V
Fzd1										V
Fzd6										V
Fzd2										V
Gli2										V
Gli3										V
Tcf7l1										V
Tcf7l2										V
Bak1										V
Ddb2										V
+ 05218: Melanoma	1.8	2.1	2.3	1.6	2.3	2.4	0	1.9	0.4	3.5
Fgf21	V			V	V
Mdm2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Cdh1		V							V
Ccnd1		V			V				V
Egfr		V							V
Igf1		V	V						V
Pten			V			V				V
Met			V			V			V
Fgf1			V						V
Cdkn1a				V	V			V		V
Pdgfa					V					V
Pdgfc					V					V
E2f1					V					V
Akt1					V					V
Pik3cd					V
Mapk1					V			V		V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Braf						V
Fgf10						V				V
Pik3r2						V				V
Raf1						V		V		V
Gadd45g						V				V
Kras									V
Cdk4										V
Mitf										V
Fgfr1										V
Igf1r										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Pdgfd										V
Bad										V
Rb1										V
Akt2										V
Akt3										V
Pik3r3										V
Map2k1										V
Araf										V
Bak1										V
Ddb2										V
+ 05211: Renal cell carcinoma	2.4	1.1	1.8	1.6	1.9	1.9	0	3	0.5	3.5
Rapgef1	V	V							V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Jun	V									V
Mapk3	V					V				V
Elob		V								V
Arnt			V
Met			V			V			V
Tfe3			V		V			V
Cul2				V
Cdkn1a				V	V			V		V
Tgfb1					V					V
Rbx1					V			V		V
Vhl					V					V
Hif1a					V			V	V
Rap1b					V					V
Akt1					V					V
Pik3cd					V
Mapk1					V			V		V
Egln2						V				V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Rap1a								V		V
Egln3									V
Tgfa									V
Sos1									V
Kras									V
Ptpn11										V
Tgfb2										V
Tgfb3										V
Slc2a1										V
Eloc										V
Egln1										V
Flcn										V
Rac1										V
Pak2										V
Cdc42										V
Akt2										V
Akt3										V
Pik3r3										V
Map2k1										V
Araf										V
Bad										V
Prcc										V
+ 05219: Bladder cancer	0.9	2.9	0	1.5	2.1	1.6	1.1	2.2	0.7	2
Mdm2	V	V			V					V
Mapk3	V					V				V
Egfr		V							V
Cdh1		V							V
Dapk3		V				V
Ccnd1		V			V				V
Tymp				V
Cdkn1a				V	V			V		V
Mmp2					V					V
Thbs1					V					V
E2f1					V					V
Mapk1					V			V		V
Hbegf					V
Mmp9						V				V
Braf						V
Raf1						V		V		V
Dapk2							V
Src							V	V
Fgfr3									V
Kras									V
Erbb2										V
Myc										V
Rassf1										V
Dapk1										V
Rb1										V
Cdk4										V
Rps6ka5										V
Map2k1										V
Araf										V
+ 05215: Prostate cancer	2.6	3.7	1.4	1.7	2.2	2.3	1.2	1.4	1.3	4.4
Mdm2	V	V			V					V
Ctnnb1	V				V					V
Ikbkg	V				V				V	V
Grb2	V	V			V					V
Gsk3b	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Rela		V						V	V
Ccnd1		V			V				V
Egfr		V							V
Igf1		V	V						V
Hsp90aa1		V					V		V
Hsp90b1		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Srd5a2			V
Pten			V			V				V
Nfkbia				V				V		V
Cdkn1a				V	V			V		V
Creb3l2				V
E2f1					V					V
Creb3					V					V
Ccne1					V
Pdgfa					V					V
Pdgfc					V					V
Akt1					V					V
Pik3cd					V
Mapk1					V			V		V
Plau					V					V
Mmp3					V					V
Ar						V				V
Cdkn1b						V	V			V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Mmp9						V				V
Mtor							V			V
Zeb1							V
Kras									V
Creb3l3									V
Tgfa									V
Sos1									V
Hsp90ab1									V	V
Nfkb1										V
Bcl2										V
Tcf7l1										V
Tcf7l2										V
Foxo1										V
Erbb2										V
Fgfr1										V
Igf1r										V
Chuk										V
Ikbkb										V
Bad										V
Casp9										V
Atf4										V
Creb3l1										V
Pdgfd										V
Rb1										V
Akt2										V
Akt3										V
Pik3r3										V
Map2k1										V
Araf										V
Erg										V
Etv5										V
Plat										V
+ 05213: Endometrial cancer	2.7	2.4	0.6	1.8	2.4	3	0.8	2.8	0.3	4.4
Ctnnb1	V				V					V
Gsk3b	V									V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Ctnna1		V			V		V	V		V
Cdh1		V							V
Egfr		V							V
Ccnd1		V			V				V
Pten			V			V				V
Mlh1				V		V
Cdkn1a				V	V			V		V
Akt1					V					V
Pik3cd					V
Mapk1					V			V		V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Ilk						V	V			V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Gadd45g						V				V
Kras									V
Sos1									V
Axin2										V
Bad										V
Casp9										V
Erbb2										V
Tcf7l1										V
Tcf7l2										V
Elk1										V
Myc										V
Akt2										V
Akt3										V
Pik3r3										V
Map2k1										V
Araf										V
Bak1										V
Ddb2										V
+ 05224: Breast cancer	2.5	0.6	2.4	0.8	2.3	0.8	0.7	1.5	0.1	3.9
Mapk3	V					V				V
Grb2	V	V			V					V
Jun	V									V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ctnnb1	V				V					V
Gsk3b	V									V
Fzd4	V		V							V
Fzd8	V
Fgf21	V			V	V
Egfr		V							V
Igf1		V	V						V
Ccnd1		V			V				V
Esr1			V					V
Pten			V			V				V
Kit			V
Fgf1			V						V
Cdkn1a				V	V			V		V
Mapk1					V			V		V
Shc2					V					V
Notch2					V			V	V
Notch4					V		V			V
Fos					V					V
Pik3cd					V
Akt1					V					V
Dvl1					V					V
Wnt11					V					V
Wnt5a					V					V
Wnt8b					V
E2f1					V					V
Nfkb2					V					V
Brca1					V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Braf						V
Raf1						V		V		V
Pik3r2						V				V
Wnt2b						V				V
Fgf10						V				V
Gadd45g						V				V
Mtor							V			V
Dll1							V
Heyl							V			V
Kras									V
Sos1									V
Rps6kb1									V
Wnt2									V
Wnt5b									V	V
Flt4									V
Ncoa1										V
Araf										V
Map2k1										V
Jag1										V
Jag2										V
Notch1										V
Notch3										V
Rps6kb2										V
Igf1r										V
Erbb2										V
Dll4										V
Pik3r3										V
Akt2										V
Akt3										V
Myc										V
Tcf7l1										V
Tcf7l2										V
Axin2										V
Dvl2										V
Fzd1										V
Fzd6										V
Fzd2										V
Wnt9a										V
Wnt6										V
Cdk4										V
Rb1										V
Fgfr1										V
Fgf18										V
Fgf2										V
Fgf7										V
Fgf9										V
Hey1										V
Hey2										V
Bak1										V
Ddb2										V
+ 05222: Small cell lung cancer	1	0.4	1.4	1.8	2.4	2.1	1.2	2.8	0.4	5.3
Itga3	V					V	V			V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Ikbkg	V				V				V	V
Ccnd1		V			V				V
Rela		V						V	V
Rxra			V	V					V
Pten			V			V				V
Lamb1			V			V				V
Nfkbia				V				V		V
Cdkn1a				V	V			V		V
Ccne1					V
Itgb1					V					V
Itga6					V					V
Akt1					V					V
Cks2					V				V
Pik3cd					V
Col4a1					V					V
Col4a2					V					V
Fn1					V	V	V	V	V
E2f1					V					V
Bax					V			V		V
Gadd45a					V					V
Gadd45b					V			V		V
Cdkn1b						V	V			V
Cks1b						V				V
Pik3r2						V				V
Ptk2						V	V			V
Gadd45g						V				V
Lamc2								V
Bcl2l1								V
Rxrb									V	V
Xiap									V
Traf4									V
Zbtb17										V
Rxrg										V
Akt2										V
Akt3										V
Casp9										V
Apaf1										V
Max										V
Myc										V
Pik3r3										V
Fhit										V
Col4a4										V
Col4a5										V
Lama2										V
Lama4										V
Lamb2										V
Lamc1										V
Col4a6										V
Birc3										V
Bcl2										V
Nos2										V
Chuk										V
Ikbkb										V
Traf1										V
Traf2										V
Cdk4										V
Nfkb1										V
Rb1										V
Cdkn2b										V
Bak1										V
Ddb2										V
+ 05223: Non-small cell lung cancer	1.5	1.7	0.5	1.7	3.2	1.5	0.2	3	0.8	3.6
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Grb2	V	V			V					V
Mapk3	V					V				V
Ccnd1		V			V				V
Egfr		V							V
Stat3		V			V			V
Rxra			V	V					V
Cdkn1a				V	V			V		V
Akt1					V					V
Pik3cd					V
E2f1					V					V
Plcg2					V			V		V
Stk4					V
Rassf5					V				V
Mapk1					V			V		V
Stat5b					V
Gadd45a					V					V
Gadd45b					V			V		V
Bax					V			V		V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Gadd45g						V				V
Stat5a							V			V
Kras									V
Tgfa									V
Sos1									V
Rxrb									V	V
Prkcb										V
Casp9										V
Bad										V
Akt2										V
Akt3										V
Pik3r3										V
Cdk4										V
Plcg1										V
Erbb2										V
Rb1										V
Rxrg										V
Rassf1										V
Fhit										V
Map2k1										V
Araf										V
Bak1										V
Ddb2										V
+ 6.12 Drug resistance: antineoplastic	5.1	3.3	2.1	2.4	3.6	4.6	2.6	3.5	4.2	5.9
+ 01521: EGFR tyrosine kinase inhibitor resistance	1.7	1.5	1.6	0.9	1.2	2.6	1	2.7	0.9	3.3
Gsk3b	V									V
Grb2	V	V			V					V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Egfr		V							V
Stat3		V			V			V
Igf1		V	V						V
Pten			V			V				V
Met			V			V			V
Eif4e2				V		V
Shc2					V					V
Plcg2					V			V		V
Pik3cd					V
Akt1					V					V
Mapk1					V			V		V
Bax					V			V		V
Pdgfa					V					V
Pdgfc					V					V
Eif4ebp1						V	V			V
Pik3r2						V				V
Braf						V
Raf1						V		V		V
Gas6						V				V
Mtor							V			V
Src							V	V
Bcl2l1								V
Erbb3									V
Rps6kb1									V
Tgfa									V
Sos1									V
Kras									V
Fgfr3									V
Il6ra									V
Erbb2										V
Rps6kb2										V
Bad										V
Prkcb										V
Plcg1										V
Pik3r3										V
Akt2										V
Akt3										V
Map2k1										V
Araf										V
Nf1										V
Igf1r										V
Bcl2										V
Pdgfd										V
Fgf2										V
Axl										V
Rps6-ps4										V
Rps6										V
Eif4e										V
+ 01524: Platinum drug resistance	3.8	2.4	0	2.6	2.1	4.2	1	1.3	3.1	2.5
Bid	V
Fas	V				V					V
Gstt3	V					V
Gsta3	V					V	V		V
Gstt2	V					V			V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk3	V					V				V
Mdm2	V	V			V					V
Rev3l	V
Gsta2		V							V
Gstm1		V							V
Gstm3		V							V
Gstp2		V				V			V	V
Gstp1		V				V			V
Gsta1				V					V
Gstm4				V					V	V
Mlh1				V		V
Cdkn1a				V	V			V		V
Birc5					V
Casp8					V					V
Bax					V			V		V
Slc31a1					V				V
Top2a					V					V
Brca1					V
Pik3cd					V
Akt1					V					V
Mapk1					V			V		V
Polh					V
Gsta4						V
Gstm5						V				V
Gstt1						V			V
Mgst1						V	V		V	V
Mgst3						V	V			V
Gsto2						V				V
Pik3r2						V				V
Bcl2l1								V
Xiap									V
Atp7b									V
Abcc2									V
Gstm6									V
Gsto1									V
Gstm7									V
Bcl2										V
Casp9										V
Bad										V
Birc3										V
Apaf1										V
Fadd										V
Bak1										V
Pmaip1										V
Gstm2										V
Xpa										V
Ercc1										V
Msh2										V
Erbb2										V
Pik3r3										V
Akt2										V
Akt3										V
+ 01523: Antifolate resistance	1.9	0.6	0	0	0.6	0	0.6	0.6	3.8	1.4
Abcc3	V				V				V
Dhfr	V								V
Ikbkg	V				V				V	V
Rela		V						V	V
Tnf					V
Gart							V
Slc19a1									V	V
Abcc2									V
Slc46a1									V
Il1b									V
Shmt2									V
Shmt1									V
Mthfr									V
Folr1										V
Folr2										V
Abcc1										V
Abcc4										V
Abcc5										V
Ggh										V
Atic										V
Chuk										V
Ikbkb										V
Nfkb1										V
+ 01522: Endocrine resistance	2.7	2.1	2.6	1.3	3.2	2.4	2.6	2.4	0.6	4.5
Mapk3	V					V				V
Grb2	V	V			V					V
Adcy6	V					V				V
Pik3r1	V			V		V				V
Pik3cb	V					V				V
Mapk8	V
Mdm2	V	V			V					V
Jun	V									V
Egfr		V							V
Ccnd1		V			V				V
Igf1		V	V						V
Bik		V	V
Esr1			V					V
Mapk14			V	V	V				V
Ncor1			V
Cdkn1a				V	V			V		V
Mmp2					V					V
Hbegf					V
Mapk1					V			V		V
Shc2					V					V
Adcy3					V					V
Adcy7					V
Pik3cd					V
Akt1					V					V
Mapk12					V					V
Notch2					V			V	V
Notch4					V		V			V
E2f1					V					V
Fos					V					V
Bax					V			V		V
Mmp9						V				V
Braf						V
Raf1						V		V		V
Gnas						V				V
Pik3r2						V				V
Cdkn2c						V	V			V
Cdkn1b						V	V			V
Ptk2						V	V			V
Src							V	V
Mtor							V			V
Dll1							V
Kras									V
Sos1									V
Adcy9									V
Rps6kb1									V
Abcb11									V
Gper1										V
Prkaca										V
Araf										V
Map2k1										V
Adcy4										V
Adcy5										V
Pik3r3										V
Akt2										V
Akt3										V
Mapk11										V
Mapk9										V
Jag1										V
Jag2										V
Notch1										V
Notch3										V
Cdk4										V
Rb1										V
Rps6kb2										V
Igf1r										V
Erbb2										V
Bcl2										V
Bad										V
Dll4										V