• Score Type:
• Meta Z-score
• Z-score
• No. of Genes

HisBIM: A Hierarchical System Biology Model

System/Subsystem/Pathway	Z-score
	脂肪肝上升基因	脂肪肝下降基因	治療後上升基因	治療後下降基因
	340/652	302/553	142/306	197/355
+ 1. Metabolism	20	10.2	5.3	12
+ 1.0 Global and overview maps	10.7	2.9	2.5	6.4
+ 01100: Metabolic pathways	12.4	4.1	3.3	6.9
Hexb	V
Chkb	V
Etnk2	V
Fasn	V			V
Acsf3	V
Kyat3	V
Kyat1	V
Hadh	V
Pomt1	V
Pts	V
Bckdhb	V
Gal3st1	V
Fads2	V
Elovl5	V			V
Fads1	V
Acaa1a	V
Acox1	V
Scp2	V	V		V
Acaa1b	V			V
Gstt3	V
Gsta3	V
Gstt2	V
Gstk1	V
Dglucy	V
Glul	V
Gls2	V			V
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Pgm1	V
Pik3cb	V
Ipmk	V
Maob	V
Hnmt	V
Acadm	V
Aldh4a1	V			V
Alas1	V		V	V
Sds	V
Enpp3	V
Upp2	V		V
Tk1	V
Tk2	V			V
Adcy6	V
Nme2	V
Uox	V
Pklr	V
Gda	V
Selenbp1	V			V
Esd	V
Acss2	V			V
Hagh	V
Acaca	V
Dhdh	V
Chac1	V
Gaa	V			V
Pcyt1a	V
Chpt1	V
Nagk	V
Cyp2c50	V			V
Cyp2a4	V
Cyp2c39	V
Prdx6	V
Tpk1	V
Hykk	V
Lpin2	V
Papss2	V
Hsd11b1	V
Hsd3b2	V		V
Ugp2	V
Ido2	V
Gamt	V
Pgls	V
Dcxr	V
Gne	V
Gcdh	V
Dhtkd1	V		V
Asl	V
Haao	V
Aox3	V
Bhmt	V
Ivd	V
Mccc1	V
Acat1	V
Dhcr7	V	V		V
Akr1d1	V
Cyp17a1	V
Fbp1	V
Cmpk1	V
Uck1	V
Pla2g6	V			V
Agpat2	V
Gpam	V			V
Gpat3	V
Smpd2	V
Sgms2	V
Asah2	V
Cers2	V
Nmnat1	V	V
Nudt12	V
Nmnat3	V
Nadsyn1	V
Sirt2	V
Sirt5	V
Sirt1	V		V	V
Nadk2	V		V
Nnmt	V
Dgat1	V
Lipg	V			V
Cmbl	V
Pank1	V
Coasy	V
Cpox	V
Oat	V			V
Hao2	V
Acsm3	V
Gk	V
Hsd17b10	V		V
Gck	V			V
Alg3	V	V
Extl2	V
Extl1	V
Idh1	V
Acot2	V
Acot3	V		V
Acot4	V		V
Aldh1a1	V
Rdh16	V
Dhrs4	V
Treh	V
Ahcyl2	V	V		V
Acss3	V
Gys2	V
Csgalnact2	V
Nqo1	V
Dhfr	V
Qdpr	V			V
Suox	V
Prodh2	V		V
Prodh	V
Inmt	V
Cox4i1	V
Ndufs8	V
Ndufa11	V			V
Suv39h1	V
Kmt2e	V
Etnk1		V
Cyp1a2		V
Gmppb		V		V
Gmppa		V
Tkfc		V
Gsta2		V
Gstm1		V
Gstm3		V
Gstp2		V
Gstp1		V
Nat8		V
Pi4kb		V
Pik3c2a		V
Mtmr4		V
Ddc		V
Keg1		V	V
Cad		V
Sdsl		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Pnp		V
Pnp2		V
Entpd8		V
Nme6		V
Cant1		V
Aprt		V
Pfkfb3		V
Elovl1		V		V
Cyp2c40		V
Cyp3a11		V		V
Cyp2c70		V	V
Cyp2c68		V
Cyp2c55		V
Papss1		V
Comt		V
Ugdh		V
Gfpt1		V
Asns		V
Acmsd		V
Acsl4		V
Sqle		V
Lss		V		V
Tm7sf2		V
Hsd17b2		V
Cyp2r1		V
Csad		V
Cyp4a12b		V
Cyp4a12a		V
Idi1		V
Fdps		V		V
Alg8		V
St6gal1		V
Galnt18		V
St3gal1		V
St3gal5		V
Coq7		V
Dhrs9		V
Gcnt4		V
St3gal4		V
H6pd		V	V
Nsd3		V
Crls1			V
Pten			V
Pik3c3			V
Afmid			V
Bcat2			V
Ugt2b34			V
Cda			V
Nudt16			V
Mocs1			V
Mgat1			V
Cyp2c54			V
Cyp7a1			V
Acsl1			V
Slc27a5			V
Urad			V
Sirt3			V
Naga			V	V
Slc33a1			V
Acot5			V
Acot1			V
Ampd2			V
Cox5a			V
Ndufs2			V	V
Ndufab1			V
Ezh2			V
Msmo1				V
Gsta1				V
Gstm4				V
Pi4k2a				V
Tymp				V
Acacb				V
Alg2				V
Elovl3				V
Srm				V
Hmgcs1				V
Lpin1				V
Pgd				V
Ass1				V
Cdo1				V
Dnmt3a				V
Tat				V
Hpd				V
Hal				V
Acsl3				V
Mvd				V
Hsd17b7				V
Sc5d				V
Tkt				V
Me1				V
Pcyt2				V
Phospho1				V
Nnt				V
Galnt11				V
Dpagt1				V
Rdh11				V
Pigs				V
Mocs2				V
Hmgcr				V
Acly				V
Atp5d				V
+ 01200: Carbon metabolism	3.2	0.5	0.2	1.9
Fbp1	V
Gck	V			V
Pgls	V
Pklr	V
Idh1	V
Acat1	V
Sds	V
Esd	V
Acox1	V
Acss2	V			V
Hao2	V
H6pd		V	V
Sdsl		V
Tkfc		V
Tkt				V
Pgd				V
Me1				V
+ 01210: 2-Oxocarboxylic acid metabolism	0.8	0	1.2	0
Idh1	V
Bcat2			V
+ 01212: Fatty acid metabolism	5.9	1.2	0.5	4
Fasn	V			V
Acat1	V
Acaa1a	V
Acaa1b	V			V
Hadh	V
Fads2	V
Elovl5	V			V
Fads1	V
Scp2	V	V		V
Acox1	V
Acaca	V
Cpt1a	V
Acadm	V
Acsf3	V
Elovl1		V		V
Acsl4		V
Acsl1			V
Elovl3				V
Acsl3				V
+ 01230: Biosynthesis of amino acids	1.7	0.5	0.4	1.5
Pklr	V
Sds	V
Idh1	V
Asl	V
Glul	V
Sdsl		V
Asns		V
Bcat2			V
Tkt				V
Ass1				V
Tat				V
+ 1.1 Carbohydrate metabolism	8.9	3.1	1.3	4.7
+ 00010: Glycolysis / Gluconeogenesis	3.7	0	0	1.6
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Pklr	V
Fbp1	V
Pgm1	V
Gck	V			V
Acss2	V			V
+ 00020: Citrate cycle (TCA cycle)	0.5	0	0	0.8
Idh1	V
Acly				V
+ 00030: Pentose phosphate pathway	1.8	0.6	0.9	1.6
Fbp1	V
Pgls	V
Pgm1	V
H6pd		V	V
Tkt				V
Pgd				V
+ 00040: Pentose and glucuronate interconversions	1.7	2.5	0.9	0
Dcxr	V
Ugp2	V
Dhdh	V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Ugdh		V
Ugt2b34			V
+ 00051: Fructose and mannose metabolism	0.4	2.5	0	0.8
Fbp1	V
Pfkfb3		V
Gmppb		V		V
Gmppa		V
Tkfc		V
+ 00052: Galactose metabolism	2.4	0	0	1.7
Gaa	V			V
Gck	V			V
Pgm1	V
Ugp2	V
+ 00053: Ascorbate and aldarate metabolism	2.6	2.8	1	0.9
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Ugdh		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Ugt2b34			V
+ 00500: Starch and sucrose metabolism	4	0	0	1.6
Gaa	V			V
Enpp3	V
Ugp2	V
Gys2	V
Pgm1	V
Gck	V			V
Treh	V
+ 00520: Amino sugar and nucleotide sugar metabolism	2.9	2.1	0	2
Nagk	V
Gne	V
Hexb	V
Pgm1	V
Ugp2	V
Gck	V			V
Gfpt1		V
Ugdh		V
Gmppb		V		V
Gmppa		V
Cyb5r3				V
+ 00620: Pyruvate metabolism	4.8	0	0	2.9
Pklr	V
Hagh	V
Acss2	V			V
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Acat1	V
Acaca	V
Me1				V
Acacb				V
+ 00630: Glyoxylate and dicarboxylate metabolism	2.5	0	0.9	0.8
Hao2	V
Acat1	V
Glul	V
Acss2	V			V
Afmid			V
+ 00640: Propanoate metabolism	3.5	0	0	1.6
Acaca	V
Acss3	V
Acss2	V			V
Acat1	V
Bckdhb	V
Acox1	V
Acacb				V
+ 00650: Butanoate metabolism	2	0	0	0.9
Acat1	V
Hadh	V
Acsm3	V
Hmgcs1				V
+ 00562: Inositol phosphate metabolism	0.5	1.1	1.1	0.4
Ipmk	V
Pik3cb	V
Pi4kb		V
Mtmr4		V
Pik3c2a		V
Pten			V
Pik3c3			V
Pi4k2a				V
+ 1.2 Energy metabolism	2.2	0.7	0.5	1.2
+ 00190: Oxidative phosphorylation	0.2	0	0.9	0.8
Cox4i1	V
Ndufa11	V			V
Ndufs8	V
Ndufab1			V
Ndufs2			V	V
Cox5a			V
Atp5d				V
+ 00910: Nitrogen metabolism	0.8	0	0	0
Glul	V
+ 00920: Sulfur metabolism	2.9	1.1	0	1.4
Suox	V
Papss2	V
Selenbp1	V			V
Papss1		V
+ 1.3 Lipid metabolism	10.7	5.4	4.5	8.4
+ 00061: Fatty acid biosynthesis	2.3	0.8	1.2	2.9
Fasn	V			V
Acaca	V
Acsf3	V
Acsl4		V
Acsl1			V
Acacb				V
Acsl3				V
+ 00062: Fatty acid elongation	3.1	0.6	3.4	2.5
Hadh	V
Acot2	V
Acot3	V		V
Acot4	V		V
Elovl5	V			V
Elovl1		V		V
Acot5			V
Acot1			V
Elovl3				V
+ 00071: Fatty acid degradation	5.9	1.5	0.6	1.9
Hadh	V
Acadm	V
Eci2	V
Acat1	V
Acaa1a	V
Acaa1b	V			V
Gcdh	V
Acox1	V
Cpt1a	V
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Cyp4a12b		V
Cyp4a12a		V
Acsl4		V
Acsl1			V
Acsl3				V
+ 00072: Synthesis and degradation of ketone bodies	1.1	0	0	1.4
Acat1	V
Hmgcs1				V
+ 00100: Steroid biosynthesis	0.7	3.8	0	5
Dhcr7	V	V		V
Tm7sf2		V
Lss		V		V
Cyp2r1		V
Sqle		V
Sc5d				V
Msmo1				V
Hsd17b7				V
Lipa				V
+ 00120: Primary bile acid biosynthesis	2.5	1.8	2.3	1.2
Cyp46a1	V
Akr1d1	V
Scp2	V	V		V
Cyp7b1		V
Cyp7a1			V
Slc27a5			V
+ 00140: Steroid hormone biosynthesis	2.3	4.7	3.6	1.9
Cyp17a1	V
Hsd3b2	V		V
Cyp2c50	V			V
Cyp2c39	V
Cyp2d26	V
Akr1d1	V
Hsd11b1	V
Hsd17b2		V
Cyp7b1		V
Cyp1a2		V
Cyp2c40		V
Cyp3a11		V		V
Cyp2c70		V	V
Cyp2c68		V
Cyp2c55		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Comt		V
Cyp2c54			V
Srd5a3			V	V
Srd5a2			V
Ugt2b34			V
Cyp7a1			V
Hsd17b7				V
+ 00561: Glycerolipid metabolism	5.1	0.2	0	2.9
Lipg	V			V
Dgat1	V
Lpin2	V
Mogat1	V
Agpat2	V
Gpam	V			V
Gpat3	V
Gk	V
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Tkfc		V
Lpin1				V
Plpp5				V
+ 00564: Glycerophospholipid metabolism	3.7	0.3	0.8	2.7
Lpcat3	V
Chpt1	V
Pcyt1a	V
Chkb	V
Etnk2	V
Pla2g6	V			V
Lpin2	V
Agpat2	V
Gpam	V			V
Gpat3	V
Lypla1	V
Etnk1		V
Pnpla7		V
Gpcpd1			V
Crls1			V
Pcyt2				V
Lpin1				V
Plpp5				V
Phospho1				V
+ 00565: Ether lipid metabolism	1.3	0	0	1.3
Chpt1	V
Pla2g6	V			V
Gal3st1	V
Enpp2				V
+ 00600: Sphingolipid metabolism	2.4	0.4	0	0.6
Asah2	V
Cers2	V
Smpd2	V
Gal3st1	V
Sgms2	V
Arsa		V		V
+ 00590: Arachidonic acid metabolism	0.6	2.2	0.9	0.8
Cyp2c50	V			V
Cyp2c39	V
Pla2g6	V			V
Cyp2c40		V
Cyp2c70		V	V
Cyp2c68		V
Cyp2c55		V
Cyp4a12b		V
Cyp4a12a		V
Cyp2c54			V
+ 00591: Linoleic acid metabolism	1.3	3.1	1.4	1.9
Pla2g6	V			V
Cyp2c50	V			V
Cyp2c39	V
Cyp1a2		V
Cyp2c40		V
Cyp2c70		V	V
Cyp2c68		V
Cyp2c55		V
Cyp3a11		V		V
Cyp2c54			V
+ 00592: alpha-Linolenic acid metabolism	3.3	0	0	1.8
Acox1	V
Acaa1a	V
Acaa1b	V			V
Pla2g6	V			V
Fads2	V
+ 01040: Biosynthesis of unsaturated fatty acids	5.6	1.3	3.3	3.7
Fads2	V
Acaa1a	V
Scp2	V	V		V
Acaa1b	V			V
Acox1	V
Acot2	V
Acot3	V		V
Acot4	V		V
Elovl5	V			V
Fads1	V
Elovl1		V		V
Acot5			V
Acot1			V
Elovl3				V
+ 1.4 Nucleotide metabolism	3.6	3.4	1.6	0.8
+ 00230: Purine metabolism	1.9	1.9	1	0
Adcy6	V
Nme2	V
Gda	V
Uox	V
Papss2	V
Pklr	V
Pgm1	V
Enpp3	V
Entpd8		V
Nme6		V
Aprt		V
Pnp		V
Pnp2		V
Cant1		V
Papss1		V
Ampd2			V
Urad			V
Nudt16			V
+ 00240: Pyrimidine metabolism	3.1	2.9	1.3	1.2
Nme2	V
Cmpk1	V
Uck1	V
Upp2	V		V
Tk1	V
Tk2	V			V
Enpp3	V
Cad		V
Nme6		V
Entpd8		V
Cant1		V
Pnp		V
Pnp2		V
Cda			V
Tymp				V
+ 1.5 Amino acid metabolism	11.1	2.5	2.5	5.7
+ 00250: Alanine, aspartate and glutamate metabolism	2.2	1.8	0	2.3
Asl	V
Glul	V
Gls2	V			V
Aldh4a1	V			V
Asns		V
Cad		V
Gfpt1		V
Ass1				V
+ 00260: Glycine, serine and threonine metabolism	2.7	0.4	0.8	0.7
Bhmt	V
Gamt	V
Sds	V
Alas1	V		V	V
Maob	V
Sdsl		V
+ 00270: Cysteine and methionine metabolism	2.3	0.8	0.6	3.1
Kyat3	V
Kyat1	V
Bhmt	V
Ahcyl2	V	V		V
Sds	V
Sdsl		V
Bcat2			V
Tat				V
Srm				V
Dnmt3a				V
Cdo1				V
+ 00280: Valine, leucine and isoleucine degradation	6.5	0	1.3	1.8
Bckdhb	V
Acat1	V
Mccc1	V
Ivd	V
Acaa1a	V
Acaa1b	V			V
Hadh	V
Aox3	V
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Hsd17b10	V		V
Acadm	V
Acsf3	V
Bcat2			V
Hmgcs1				V
+ 00290: Valine, leucine and isoleucine biosynthesis	1.6	1.6	1.9	0
Sds	V
Sdsl		V
Bcat2			V
+ 00310: Lysine degradation	4.8	0.3	1.2	0.5
Hadh	V
Dhtkd1	V		V
Acat1	V
Gcdh	V
Aldh9a1	V
Suv39h1	V
Kmt2e	V
Aldh2	V
Aldh3a2	V
Aldh1b1	V			V
Hykk	V
Nsd3		V
Ezh2			V
+ 00220: Arginine biosynthesis	2.3	0	0	2.1
Gls2	V			V
Glul	V
Asl	V
Ass1				V
+ 00330: Arginine and proline metabolism	5.1	0	0.6	2.6
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Maob	V
Gamt	V
Oat	V			V
Prodh	V
Aldh4a1	V			V
Prodh2	V		V
L3hypdh	V
Srm				V
+ 00340: Histidine metabolism	4	0	0	1.9
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Maob	V
Hnmt	V
Hal				V
+ 00350: Tyrosine metabolism	0.9	1.1	0	1.5
Maob	V
Aox3	V
Ddc		V
Comt		V
Hpd				V
Tat				V
+ 00360: Phenylalanine metabolism	0.7	1.6	1.1	1.9
Maob	V
Ddc		V
Keg1		V	V
Hpd				V
Tat				V
+ 00380: Tryptophan metabolism	6.9	1.5	1.4	0.6
Hadh	V
Ido2	V
Maob	V
Acat1	V
Gcdh	V
Dhtkd1	V		V
Haao	V
Kyat3	V
Kyat1	V
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Aox3	V
Inmt	V
Cyp1a2		V
Ddc		V
Acmsd		V
Afmid			V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	1.6
Tat				V
+ 1.6 Metabolism of other amino acids	5.5	2.1	0	3
+ 00410: beta-Alanine metabolism	3	0	0	0.8
Aldh2	V
Aldh3a2	V
Aldh9a1	V
Aldh1b1	V			V
Acox1	V
+ 00430: Taurine and hypotaurine metabolism	0	1.1	0	1.4
Csad		V
Cdo1				V
+ 00440: Phosphonate and phosphinate metabolism	2.5	0	0	1.7
Pcyt1a	V
Chpt1	V
Pcyt2				V
+ 00450: Selenocompound metabolism	3.8	1.8	0	0
Kyat3	V
Kyat1	V
Pstk	V
Papss2	V
Inmt	V
Txnrd1		V
Papss1		V
+ 00471: D-Glutamine and D-glutamate metabolism	2.8	0	0	1.8
Dglucy	V
Gls2	V			V
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0
+ 00480: Glutathione metabolism	2.4	2.7	0	2.2
Idh1	V
Gstt3	V
Gsta3	V
Gstt2	V
Gstk1	V
Chac1	V
Nat8		V
Gsta2		V
Gstm1		V
Gstm3		V
Gstp2		V
Gstp1		V
Gsta1				V
Gstm4				V
Pgd				V
Srm				V
+ 1.7 Glycan biosynthesis and metabolism	2.7	3	1.3	1.7
+ 00510: N-Glycan biosynthesis	0.3	1.5	1.4	2
Alg3	V	V
St6gal1		V
Alg8		V
Mgat1			V
Srd5a3			V	V
Alg2				V
Dpagt1				V
+ 00513: Various types of N-glycan biosynthesis	0.9	0.4	0.8	0.7
Alg3	V	V
Hexb	V
Mgat1			V
Alg2				V
+ 00512: Mucin type O-glycan biosynthesis	0	2.1	0	0.9
St3gal1		V
Galnt18		V
Gcnt4		V
Galnt11				V
+ 00515: Mannose type O-glycan biosynthesis	0.6	0	0	0
Pomt1	V
+ 00514: Other types of O-glycan biosynthesis	0.3	1.6	0	0.6
Pomt1	V
St6gal1		V
Gxylt1		V
Galnt18		V
Galnt11				V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.8	0	0	0
Csgalnact2	V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1.5	0	0	0
Extl2	V
Extl1	V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	1	0	0
St3gal1		V
+ 00531: Glycosaminoglycan degradation	0.7	0	0	0
Hexb	V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	0	0	1
Pigs				V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0	0.7	0	0
St3gal4		V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0.8	0.9	1.3	1.2
Hexb	V
St3gal1		V
Naga			V	V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0.9	1.9	1.3	0
Hexb	V
St3gal1		V
St3gal5		V
Slc33a1			V
+ 00511: Other glycan degradation	3.1	0.9	0	0
Man2c1	V	V
Fuca2	V
Aga	V
Hexb	V
+ 1.8 Metabolism of cofactors and vitamins	5.8	2.6	2.2	2.5
+ 00730: Thiamine metabolism	0.9	0	0	0
Tpk1	V
+ 00740: Riboflavin metabolism	1.2	0	0	0
Enpp3	V
+ 00750: Vitamin B6 metabolism	1.2	0	0	0
Aox3	V
+ 00760: Nicotinate and nicotinamide metabolism	5.4	1.6	2.2	1.4
Nudt12	V
Enpp3	V
Nmnat1	V	V
Nmnat3	V
Nadsyn1	V
Nnmt	V
Nadk2	V		V
Aox3	V
Sirt2	V
Sirt5	V
Sirt1	V		V	V
Pnp		V
Pnp2		V
Sirt3			V
Nnt				V
+ 00770: Pantothenate and CoA biosynthesis	3.8	0	1.2	0
Coasy	V
Enpp3	V
Pank1	V
Vnn1	V
Vnn3	V
Bcat2			V
+ 00780: Biotin metabolism	0	0	0	0
+ 00785: Lipoic acid metabolism	0	0	0	0
+ 00790: Folate biosynthesis	2	0	1	1.8
Dhfr	V
Qdpr	V			V
Pts	V
Mocs1			V
Mocs2				V
+ 00670: One carbon pool by folate	0.8	0	0	1.1
Dhfr	V
Aldh1l1				V
+ 00830: Retinol metabolism	2.7	4.6	1.4	1.3
Aldh1a1	V
Aox3	V
Dgat1	V
Rdh16	V
Dhrs4	V
Cyp2a4	V
Cyp2c50	V			V
Cyp2c39	V
Cyp3a11		V		V
Cyp1a2		V
Dhrs9		V
Cyp4a12b		V
Cyp4a12a		V
Cyp2c40		V
Cyp2c70		V	V
Cyp2c68		V
Cyp2c55		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Cyp2c54			V
Ugt2b34			V
Rdh11				V
+ 00860: Porphyrin and chlorophyll metabolism	0.9	1.7	1.6	0.7
Cpox	V
Alas1	V		V	V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Ugt2b34			V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	1.1	1.1	0	2.5
Nqo1	V
Coq7		V
Hpd				V
Tat				V
+ 1.9 Metabolism of terpenoids and polyketides	0.6	1.5	0	3.5
+ 00900: Terpenoid backbone biosynthesis	0.6	1.5	0	3.5
Acat1	V
Idi1		V
Fdps		V		V
Hmgcs1				V
Hmgcr				V
Mvd				V
+ 1.10 Biosynthesis of other secondary metabolites	2	1	0	1.2
+ 00232: Caffeine metabolism	1.4	1.4	0	0
Uox	V
Cyp1a2		V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	1.5	0	0	1.7
Gck	V			V
+ 1.11 Xenobiotics biodegradation and metabolism	5.6	7.1	2.1	2.6
+ 00980: Metabolism of xenobiotics by cytochrome P450	2.4	4.5	0.5	1
Gstt3	V
Gsta3	V
Gstt2	V
Gstk1	V
Dhdh	V
Hsd11b1	V
Gsta2		V
Gstm1		V
Gstm3		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Gstp2		V
Gstp1		V
Ephx1		V
Cyp1a2		V
Ugt2b34			V
Gsta1				V
Gstm4				V
+ 00982: Drug metabolism - cytochrome P450	3.2	4	0.5	1.6
Fmo1	V			V
Fmo5	V
Gstt3	V
Gsta3	V
Gstt2	V
Gstk1	V
Maob	V
Aox3	V
Cyp1a2		V
Gsta2		V
Gstm1		V
Gstm3		V
Gstp2		V
Gstp1		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Ugt2b34			V
Gsta1				V
Gstm4				V
+ 00983: Drug metabolism - other enzymes	4	3.9	2.6	1.9
Upp2	V		V
Uck1	V
Tk1	V
Tk2	V			V
Ces1d	V		V
Ces1f	V
Cmpk1	V
Nme2	V
Gstt3	V
Gsta3	V
Gstt2	V
Ces2a		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Nme6		V
Gsta2		V
Gstm1		V
Gstm3		V
Gstp2		V
Gstp1		V
Cda			V
Ces2c			V
Ugt2b34			V
Tymp				V
Gsta1				V
Gstm4				V
+ 2. Genetic Information Processing	3.1	8.5	2.2	6.2
+ 2.1 Transcription	0	4.7	1.6	1.4
+ 03020: RNA polymerase	0	2.1	1	0
Polr1d		V	V
Polr1b		V
Znrd1		V
+ 03022: Basal transcription factors	0	2.2	0.7	0.6
Gtf2b		V
Gtf2ird1		V
Gtf2f1		V
Ercc2		V
Gtf2a2			V
Mnat1				V
+ 03040: Spliceosome	0	3.8	1.1	1.8
Snrpa		V
Sf3a1		V
Sf3a3		V
Sf3b1		V
U2af1		V
Puf60		V
Hnrnpc		V
Hnrnpm		V	V
Srsf5		V	V
Plrg1		V
Prpf6		V
Acin1		V
Rbm25			V
Snrnp70				V
Prpf40b				V
Srsf2				V
Srsf7				V
Prpf19				V
+ 2.2 Translation	1.2	5.8	0.7	2
+ 03010: Ribosome	0.3	3.3	0.2	1.3
Rps25	V
Rplp0	V
Mrpl1	V
Rps19		V
Rps24		V		V
Rps28		V
Rpl12		V
Rpl5		V	V	V
Rpl35		V
Rpl7		V
Rpl36a		V
Rpl36al		V
Rpl37rt		V
Rpl37		V
Mrpl28				V
Rpsa				V
+ 00970: Aminoacyl-tRNA biosynthesis	1.4	4.3	0.7	1.4
Farsb	V	V		V
Tars2	V
Pstk	V
Iars		V
Rars2		V
Sars		V
Aars		V		V
Kars		V
Wars		V
Yars		V
Farsa			V
+ 03013: RNA transport	0.3	0.8	0	1
Nxt2	V
Rangap1	V
Pop4	V
Rpp21	V
Casc3		V
Acin1		V
Sumo3		V
Eif2b4		V
Cyfip1		V
Aaas				V
Eif1a				V
Eif4a2				V
Eif4e2				V
+ 03015: mRNA surveillance pathway	0.3	0.8	0.3	0
Nxt2	V
Ppp2r1b	V
Casc3		V
Acin1		V
Papola		V
Cpsf4			V
+ 03008: Ribosome biogenesis in eukaryotes	0.4	3.7	0.4	0.9
Pop4	V
Nxt2	V
Nop58		V	V
Nop56		V
Utp14a		V
Gnl2		V
Gnl3		V
Heatr1		V
Wdr43		V
Lsg1		V
Spata5		V
Dkc1				V
Csnk2b				V
+ 2.3 Folding, sorting and degradation	2.3	5.6	2	6.3
+ 03060: Protein export	2.5	5	0	3.9
Immp2l	V
Gm4184	V	V		V
Gm11575	V	V		V
Sec61g	V	V		V
Srp19		V
Spcs2		V
Sec11a		V
Srprb		V
Hspa5		V		V
Sec61a1				V
+ 04141: Protein processing in endoplasmic reticulum	1.9	6	1.3	5.7
Mapk8	V
Gm4184	V	V		V
Gm11575	V	V		V
Sec61g	V	V		V
Rad23a	V
Ube4b	V
Herpud1	V			V
Nfe2l2	V
Hsph1	V	V		V
Calr		V		V
Pdia3		V
Sec24c		V
Uggt1		V
Syvn1		V
Hspa5		V		V
Xbp1		V
Derl3		V
Selenos		V		V
Pdia4		V		V
Dnajc3		V
Dnajb11		V
Hsp90aa1		V
Preb		V
Hsp90b1		V
Hyou1		V		V
Ssr2		V
Sec24a			V
Lman1			V
Dnaja1			V
Sec31a			V
Ddit3				V
Sec61a1				V
Eif2ak3				V
Dnajb2				V
Dnajb1				V
Pdia6				V
+ 04130: SNARE interactions in vesicular transport	0	0.6	0	0.8
Stx18		V
Vamp8				V
+ 04120: Ubiquitin mediated proteolysis	0.8	0.4	1	1.8
Rhobtb1	V			V
Mdm2	V	V
Smurf1	V
Ube4b	V
Birc6	V			V
Elob		V
Syvn1		V
Itch			V
Uba7			V
Nedd4			V
Cul2				V
Prpf19				V
Herc1				V
+ 04122: Sulfur relay system	0	0	0	1.5
Mocs2				V
+ 03050: Proteasome	0.8	1.6	1.5	2.7
Psmc1	V
Psmb8	V
Psmd12		V
Psmd11		V
Psma3		V
Psma4			V
Psmb1			V
Psmd1				V
Psmc4				V
Psme2				V
Psme2b				V
+ 03018: RNA degradation	0.1	1.4	1.6	0.3
Pnldc1	V
Exosc1		V
Ttc37		V
Btg3		V
Pan2		V
Exosc5			V
Cnot1			V
Nudt16			V
Btg2				V
+ 2.4 Replication and repair	2.6	0.9	0	2.6
+ 03030: DNA replication	1.7	0	0	1.6
Pold4	V
Mcm6	V			V
Rpa1	V			V
+ 03410: Base excision repair	0.5	1.9	0	0
Pold4	V
Apex1		V
Lig3		V
Ung		V
+ 03420: Nucleotide excision repair	1.5	0.4	0	1.4
Pold4	V
Rpa1	V			V
Rad23a	V
Ercc2		V
Mnat1				V
+ 03430: Mismatch repair	1.5	0	0	2
Pold4	V
Rpa1	V			V
Mlh1				V
+ 03440: Homologous recombination	0.9	0	0	0.7
Rpa1	V			V
Pold4	V
+ 03450: Non-homologous end-joining	0	0	0	0
+ 03460: Fanconi anemia pathway	0.7	0	0	1.3
Rpa1	V			V
Rev3l	V
Mlh1				V
+ 3. Environmental Information Processing	7.4	2.9	3.7	3
+ 3.1 Membrane transport	4.4	0.4	0.7	0.6
+ 02010: ABC transporters	4.4	0.4	0.7	0.6
Abcg8	V
Abcg5	V
Abcd2	V
Abcd1	V
Abcc3	V
Abcb1a	V
Tap2	V	V
Tap1	V
Defb1	V
Abca3			V
Abcd3				V
+ 3.2 Signal transduction	7.8	3.7	4.7	4.6
+ 04010: MAPK signaling pathway	1.6	0.2	2.2	1.2
Dusp6	V			V
Ikbkg	V
Mapk3	V
Rasgrp2	V		V
Grb2	V	V
Map2k6	V		V
Map3k20	V
Fas	V
Mapk8	V
Arrb1	V
Jun	V
Rps6ka1	V			V
Fgf21	V			V
Rela		V
Egfr		V
Hspb1		V
Igf1		V	V
Kit			V
Met			V
Mapk14			V	V
Map2k3			V
Map3k13			V
Fgf1			V
Ddit3				V
Flt3l				V
Irak1				V
+ 04012: ErbB signaling pathway	2.5	0.5	0	0.8
Grb2	V	V
Gsk3b	V
Mapk8	V
Jun	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Egfr		V
Cdkn1a				V
+ 04014: Ras signaling pathway	1.6	0.2	1.6	0.6
Mapk3	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Fgf21	V			V
Ikbkg	V
Mapk8	V
Pla2g6	V			V
Rasgrp2	V		V
Exoc2	V
Shoc2	V
Igf1		V	V
Egfr		V
Rela		V
Fgf1			V
Kit			V
Met			V
Gnb2			V
Flt3l				V
+ 04015: Rap1 signaling pathway	1.6	0.7	2.5	0.4
Mapk3	V
Fgf21	V			V
Map2k6	V		V
P2ry1	V
Rapgef1	V	V
Ctnnb1	V
Rasgrp2	V		V
Adcy6	V
Pik3r1	V			V
Pik3cb	V
Igf1		V	V
Egfr		V
Cdh1		V
Rapgef4		V
Prkd3		V
Fgf1			V
Kit			V
Met			V
Map2k3			V
Mapk14			V	V
+ 04310: Wnt signaling pathway	1.6	0	0.1	0.3
Fzd4	V		V
Fzd8	V
Mapk8	V
Jun	V
Tbl1x	V
Tbl1xr1	V			V
Ctnnb1	V
Gsk3b	V
Ccnd1		V
Csnk2b				V
+ 04330: Notch signaling pathway	0.7	0.3	0.6	0
Aph1a	V
Adam17	V
Atxn1l		V
Numb			V
+ 04340: Hedgehog signaling pathway	1.9	0.4	0.7	0.6
Gsk3b	V
Smurf1	V
Grk2	V
Arrb1	V
Ccnd1		V
Spop			V
Csnk1g3				V
+ 04350: TGF-beta signaling pathway	2.6	1.6	2.5	0
Acvr1	V
Ppp2r1b	V
Zfyve16	V
Zfyve9	V		V
Mapk3	V
Smurf1	V
Dcn	V
Hamp2	V
Id3		V
Inhba		V
Bmp6		V
Smad9		V
Hamp		V	V
Smad5			V
Chrd			V
Hjv			V
+ 04390: Hippo signaling pathway	2	1.3	0.9	0.4
Frmd6	V
Wwtr1	V
Dlg1	V
Fzd4	V		V
Fzd8	V
Gsk3b	V
Ctnnb1	V
Ppp2r1b	V
Rassf6	V			V
Nf2		V
Ctnna1		V
Cdh1		V
Ajuba		V
Ccnd1		V
Bmp6		V
Dlg3			V
Fgf1			V
Ywhae				V
+ 04392: Hippo signaling pathway - multiple species	2	1.5	0	0.9
Frmd6	V
Wwtr1	V
Rassf6	V			V
Nf2		V
Ajuba		V
+ 04370: VEGF signaling pathway	1.1	0.3	0.6	1.2
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Hspb1		V
Mapk14			V	V
+ 04371: Apelin signaling pathway	0.5	0.4	0.5	0.4
Prkag2	V
Mapk3	V
Adcy6	V
Egr1	V			V
Nrf1		V
Ccnd1		V
Cdh1		V
Gnb2			V
Pik3c3			V
Itpr1				V
+ 04064: NF-kappa B signaling pathway	0.2	0.3	0.3	1.6
Ikbkg	V
Blnk	V
Rela		V
Icam1		V
Cxcl12			V
Nfkbia				V
Irak1				V
Lbp				V
Csnk2b				V
+ 04668: TNF signaling pathway	2.2	0.6	1.7	1.5
Map2k6	V		V
Mapk8	V
Ikbkg	V
Mapk3	V
Jun	V
Fas	V
Pik3r1	V			V
Pik3cb	V
Rela		V
Bcl3		V
Icam1		V
Map2k3			V
Mapk14			V	V
Itch			V
Nfkbia				V
Creb3l2				V
+ 04066: HIF-1 signaling pathway	0.4	1.7	0.7	1.5
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Elob		V
Igf1		V	V
Egfr		V
Pfkfb3		V
Rela		V
Stat3		V
Arnt			V
Cul2				V
Eif4e2				V
Cdkn1a				V
+ 04068: FoxO signaling pathway	2.3	2.3	1.5	1.3
Mapk8	V
Mapk3	V
Prkag2	V
Pik3r1	V			V
Pik3cb	V
Grb2	V	V
Mdm2	V	V
Sirt1	V		V	V
Slc2a4	V
Irs1		V
Egfr		V
Igf1		V	V
Ccnd1		V
Agap2		V
Stat3		V
Pten			V
Mapk14			V	V
Cdkn1a				V
+ 04020: Calcium signaling pathway	0.1	0.2	1.1	0.2
Vdac1	V
Gna14	V
Stim2	V
Egfr		V
Avpr1a		V	V
Atp2a2		V
Phkg2			V	V
Atp2b4			V
Stim1			V
Itpr1				V
+ 04070: Phosphatidylinositol signaling system	0.9	1.2	0.8	1.8
Pik3r1	V			V
Pik3cb	V
Ipmk	V
Ip6k2	V
Pi4kb		V
Pik3c2a		V
Mtmr4		V
Ppip5k2		V
Pten			V
Pik3c3			V
Itpr1				V
Pi4k2a				V
Pip4p1				V
+ 04072: Phospholipase D signaling pathway	1	0.6	0.5	0.1
Mapk3	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Adcy6	V
Agpat2	V
Egfr		V
Avpr1a		V	V
Rapgef4		V
Kit			V
+ 04071: Sphingolipid signaling pathway	3.2	0.5	1.1	0.5
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Cers2	V
Smpd2	V
Asah2	V
Ppp2r1b	V
Mapk8	V
Bid	V
Sgms2	V
Kng1	V
Ctsd		V
Rela		V
Adora1		V
S1pr5			V
Pten			V
Mapk14			V	V
+ 04024: cAMP signaling pathway	1	0.2	0.2	0.7
Sucnr1	V
Adcy6	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Mapk8	V
Jun	V
Acox1	V
Atp2a2		V
Adora1		V
Rapgef4		V
Rela		V
Atp2b4			V
Ppp1r1b			V
Atp1b1				V
Creb3l2				V
Nfkbia				V
+ 04022: cGMP-PKG signaling pathway	0.3	0.4	0.1	0.6
Mapk3	V
Adcy6	V
Vdac1	V
Kng1	V
Atp2a2		V
Gtf2ird1		V
Irs1		V
Adora1		V
Atp2b4			V
Itpr1				V
Creb3l2				V
Atp1b1				V
+ 04151: PI3K-Akt signaling pathway	0.8	1	1.5	1.2
Pik3r1	V			V
Pik3cb	V
Gsk3b	V
Mdm2	V	V
Gys2	V
Ikbkg	V
Fgf21	V			V
Grb2	V	V
Ppp2r1b	V
Mapk3	V
Itga3	V
Reln	V
Irs1		V
Egfr		V
Ccnd1		V
Rela		V
Igf1		V	V
Hsp90aa1		V
Hsp90b1		V
Itga5		V
Pik3ap1		V
Pten			V
Kit			V
Met			V
Fgf1			V
Gnb2			V
Lamb1			V
Rxra			V	V
Eif4e2				V
Ywhae				V
Flt3l				V
Cdkn1a				V
Creb3l2				V
+ 04152: AMPK signaling pathway	4.5	1.6	0.6	2.8
Prkag2	V
Pik3r1	V			V
Pik3cb	V
Slc2a4	V
Sirt1	V		V	V
Acaca	V
Cpt1a	V
Fbp1	V
Akt1s1	V	V
Gys2	V
Srebf1	V			V
Fasn	V			V
Pparg	V
Ppp2r1b	V
Cd36	V
Irs1		V
Igf1		V	V
Pfkfb3		V
Ccnd1		V
Lepr		V
Acacb				V
Hmgcr				V
Creb3l2				V
+ 04150: mTOR signaling pathway	2.3	0.6	0.9	2
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Rps6ka1	V			V
Grb2	V	V
Fnip2	V
Akt1s1	V	V
Gsk3b	V
Fzd4	V		V
Fzd8	V
Irs1		V
Igf1		V	V
Pten			V
Lpin1				V
Eif4e2				V
Lamtor2				V
Mapkap1				V
+ 3.3 Signaling molecules and interaction	0.6	1	1	0
+ 04080: Neuroactive ligand-receptor interaction	0	0	0.3	0
Pth1r	V
P2ry1	V
Chrna2	V
Kng1	V
Lepr		V
Gcgr		V
Adora1		V
Avpr1a		V	V
Thra			V	V
S1pr5			V
P2ry4			V
+ 04060: Cytokine-cytokine receptor interaction	0.2	0.9	0.5	0
Acvr1	V
Il18	V
Tnfrsf19	V
Fas	V
Ctf1	V
Cxcl9	V
Gdf15	V			V
Il22ra1		V
Lifr		V	V
Inhba		V
Cxcl16		V	V
Cxcl13		V
Tnfrsf12a		V
Ccl9		V
Bmp6		V
Lepr		V
Tnfrsf14			V
Cxcl12			V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	0.2	0.7	0.8	0
Cxcl9	V
Il18	V
Ccl9		V
Cxcl13		V
Il22ra1		V
Cxcl12			V
Tnfrsf14			V
+ 04512: ECM-receptor interaction	0.7	0.4	0.4	0
Cd36	V
Itga3	V
Reln	V
Sdc4		V
Itga5		V
Lamb1			V
+ 4. Cellular Processes	6.9	6	3	5.9
+ 4.1 Transport and catabolism	5.9	5.6	2.2	5
+ 04144: Endocytosis	3	2.6	1.4	0.5
Mdm2	V	V
Smurf1	V
Clta	V
Chmp6	V
Chmp2a	V	V
Epn1	V
Sh3glb2	V
Grk2	V
Grk6	V
Arrb1	V
Eea1	V			V
Zfyve16	V
Zfyve9	V		V
Washc2	V	V
Washc3	V
Rab22a	V
Wipf3	V		V
Cltc		V
Ap2a1		V
Vps37c		V		V
Eps15		V
Eps15l1		V
Egfr		V
Asap2		V
Agap2		V
Chmp7		V
Vps26a		V
Rab11fip4		V
Itch			V
Nedd4			V
Ap2b1			V
Rab11fip1			V
Ldlr				V
Spg20				V
+ 04145: Phagosome	1.4	3.5	0.4	3.4
Eea1	V			V
Cd36	V
Colec11	V
Gm4184	V	V		V
Gm11575	V	V		V
Sec61g	V	V		V
Tap1	V
Tap2	V	V
Stx18		V
Fcgr2b		V
C1rb		V	V
Itga5		V
Tuba4a		V
Tuba8		V
Tubb5		V
Tubb4b		V		V
Calr		V		V
Pik3c3			V
Dync1li2				V
Tuba1b				V
Tubb2a				V
Sec61a1				V
+ 04142: Lysosome	0.6	1.6	0.6	2.4
Gaa	V			V
Hexb	V
Aga	V
Clta	V
Ctsd		V
Arsa		V		V
Gm2a		V
Cltc		V
Ap1g1		V	V
Ap3s1		V
Naga			V	V
Lipa				V
Ap3d1				V
Ap4m1				V
+ 04146: Peroxisome	6.5	1.8	1.5	1.9
Pex7	V
Pex19	V
Pex11a	V
Pex11b	V
Acaa1a	V
Acaa1b	V			V
Acox1	V
Scp2	V	V		V
Crat	V
Dhrs4	V
Pecr	V
Eci2	V
Nudt12	V
Abcd1	V
Abcd2	V
Idh1	V
Hao2	V
Gstk1	V
Hacl1		V
Acsl4		V
Prdx1		V
Nudt7		V
Phyh			V
Acsl1			V
Mpv17			V
Abcd3				V
Acsl3				V
+ 04140: Autophagy - animal	1.5	3.3	0.5	2.2
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Akt1s1	V	V
Wipi1	V	V		V
Mapk8	V
Ambra1	V	V
Irs1		V
Atg13		V
Rb1cc1		V
Mtmr4		V
Dapk3		V
Atg16l2		V
Ctsd		V
Vmp1		V
Pten			V
Pik3c3			V
Itpr1				V
Eif2ak3				V
Atg7				V
Vamp8				V
+ 04136: Autophagy - other	0.5	1.3	0.9	1.7
Wipi1	V	V		V
Atg13		V
Pik3c3			V
Atg7				V
+ 04137: Mitophagy - animal	2	0.7	0.5	1.1
Mfn2	V
Ambra1	V	V
Tbc1d17	V
Mapk8	V
Jun	V
Rela		V
Tfe3			V
Csnk2b				V
Eif2ak3				V
+ 4.2 Cell growth and death	3.8	1.7	1.8	4.6
+ 04110: Cell cycle	1.3	0.5	0	0.9
Mcm6	V			V
Orc4	V
Orc5	V
Mdm2	V	V
Wee1	V
Gsk3b	V
Ccnd1		V
Stag2		V
Ywhae				V
Cdkn1a				V
+ 04114: Oocyte meiosis	0.7	0.1	0.7	1.5
Rps6ka1	V			V
Mapk3	V
Adcy6	V
Ppp2r1b	V
Igf1		V	V
Mapk14			V	V
Itpr1				V
Ywhae				V
+ 04210: Apoptosis	2.2	0.7	0	2.6
Casp6	V
Bid	V
Ikbkg	V
Pik3r1	V			V
Pik3cb	V
Fas	V
Mapk8	V
Jun	V
Mapk3	V
Rela		V
Ctsd		V
Tuba4a		V
Tuba8		V
Nfkbia				V
Diablo				V
Ddit3				V
Eif2ak3				V
Itpr1				V
Tuba1b				V
+ 04215: Apoptosis - multiple species	1.8	0	0	1.6
Birc6	V			V
Mapk8	V
Bid	V
Diablo				V
+ 04216: Ferroptosis	0.9	1.1	1.6	3.4
Prnp	V
Lpcat3	V
Slc39a14		V
Acsl4		V
Pcbp2			V
Acsl1			V
LOC100862446				V
Ftl1				V
Fth1				V
Atg7				V
Acsl3				V
+ 04217: Necroptosis	1.3	0.7	0.1	0.6
Fas	V
Stat1	V
Glul	V
Mapk8	V
Bid	V
Chmp6	V
Chmp2a	V	V
Vdac1	V
Stat3		V
Hsp90aa1		V
Chmp7		V
Ppid		V
Tlr3			V
LOC100862446				V
Ftl1				V
Fth1				V
+ 04115: p53 signaling pathway	1.3	1.1	1.1	1
Bid	V
Fas	V
Mdm2	V	V
Perp	V
Igf1		V	V
Ccnd1		V
Pten			V
Cdkn1a				V
Sesn1				V
+ 04218: Cellular senescence	1	0.7	1.6	1.4
Mdm2	V	V
Pik3r1	V			V
Pik3cb	V
Sirt1	V		V	V
Mapk3	V
Map2k6	V		V
Vdac1	V
Ccnd1		V
Rbbp4		V
Rela		V
Ppid		V
Mapk14			V	V
Map2k3			V
Pten			V
Cdkn1a				V
Itpr1				V
+ 4.3 Cellular community - eukaryotes	3	4.3	1.7	1.8
+ 04510: Focal adhesion	2.4	0.8	1	0.2
Itga3	V
Diaph1	V
Pik3r1	V			V
Pik3cb	V
Reln	V
Mapk3	V
Grb2	V	V
Rapgef1	V	V
Mapk8	V
Jun	V
Ctnnb1	V
Gsk3b	V
Itga5		V
Ccnd1		V
Egfr		V
Igf1		V	V
Pten			V
Lamb1			V
Met			V
Zyx				V
+ 04520: Adherens junction	0.5	2.1	0.5	0.4
Mapk3	V
Ctnnb1	V
Cdh1		V
Ctnna1		V
Egfr		V
Baiap2		V
Nectin2		V
Met			V
Csnk2b				V
+ 04530: Tight junction	0.8	2.2	0.4	1
Ppp2r1b	V
Mapk8	V
Prkag2	V
Jun	V
Dlg1	V
Myh14	V
Cgn		V
Epb41l4b		V
Igsf5		V
Marveld2		V
Cldn1		V
Tuba4a		V
Tuba8		V
Nf2		V
Ccnd1		V
Dlg3			V
Nedd4			V
Tuba1b				V
Arhgef2				V
Cttn				V
Myl6				V
+ 04540: Gap junction	0.7	2.3	0	1.9
Adcy6	V
Mapk3	V
Grb2	V	V
Tubb5		V
Tubb4b		V		V
Tuba4a		V
Tuba8		V
Egfr		V
Tubb2a				V
Tuba1b				V
Itpr1				V
+ 04550: Signaling pathways regulating pluripotency of stem cells	2.3	2.2	2	0.4
Fzd4	V		V
Fzd8	V
Ctnnb1	V
Gsk3b	V
Pik3r1	V			V
Pik3cb	V
Grb2	V	V
Acvr1	V
Mapk3	V
Lifr		V	V
Stat3		V
Inhba		V
Igf1		V	V
Smad9		V
Id3		V
Onecut1		V
Smad5			V
Mapk14			V	V
+ 4.5 Cell motility	1	0.3	0.2	0.4
+ 04810: Regulation of actin cytoskeleton	1	0.3	0.2	0.4
Diaph1	V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Itga3	V
Fgf21	V			V
Myh14	V
Kng1	V
Cyfip1		V
Baiap2		V
Itga5		V
Egfr		V
Fgf1			V
Cxcl12			V
Cfl1				V
+ 5. Organismal Systems	11.3	4.8	6.7	9.7
+ 5.1 Immune system	6.7	3.2	3.1	5
+ 04640: Hematopoietic cell lineage	0.6	0.4	0.3	0.7
Itga3	V
Cd59a	V
Cd36	V
Itga5		V
Cd9		V		V
Kit			V
Flt3l				V
+ 04610: Complement and coagulation cascades	0.6	2.1	1.4	0.3
Kng1	V
Cd59a	V
Cfd	V			V
Fgb		V
Fga		V
Fgg		V
C1rb		V	V
C8a		V
Serpina1e		V
F5			V
F8			V
+ 04611: Platelet activation	1.8	0.5	1.1	1.9
P2ry1	V
Rasgrp2	V		V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Adcy6	V
Col3a1	V			V
Fgb		V
Fga		V
Fgg		V
Mapk14			V	V
Stim1			V
Itpr1				V
Vamp8				V
+ 04620: Toll-like receptor signaling pathway	2.9	0.3	1.9	2.7
Mapk3	V
Mapk8	V
Stat1	V
Ikbkg	V
Cxcl9	V
Pik3r1	V			V
Pik3cb	V
Map2k6	V		V
Jun	V
Irf5		V
Rela		V
Mapk14			V	V
Tlr3			V
Map2k3			V
Irak1				V
Irf7				V
Nfkbia				V
Lbp				V
+ 04621: NOD-like receptor signaling pathway	1.3	0.5	0.2	1.1
Il18	V
Mapk8	V
Mapk3	V
Jun	V
Ikbkg	V
Stat1	V
Vdac1	V
Txnip	V	V
Mfn2	V
Hsp90aa1		V
Rela		V
Nlrp12		V
Nek7		V
Mapk14			V	V
Erbin			V
Irf7				V
Itpr1				V
Nfkbia				V
Ywhae				V
+ 04622: RIG-I-like receptor signaling pathway	0.9	1.1	1.1	1.6
Rnf125	V
Ikbkg	V
Mapk8	V
Rela		V
Tkfc		V
Ddx3x		V
Azi2			V
Mapk14			V	V
Irf7				V
Nfkbia				V
+ 04623: Cytosolic DNA-sensing pathway	0.6	0.7	0.5	1.1
Il18	V
Ikbkg	V
Rela		V
Polr1d		V	V
Irf7				V
Nfkbia				V
+ 04625: C-type lectin receptor signaling pathway	2.3	0.6	0.3	1.6
Ikbkg	V
Stat1	V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Mdm2	V	V
Mapk8	V
Jun	V
Rela		V
Bcl3		V
Mapk14			V	V
Nfkbia				V
Itpr1				V
+ 04650: Natural killer cell mediated cytotoxicity	1.8	0.5	0.2	0.2
Bid	V
Fas	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Grb2	V	V
Raet1d	V
Icam1		V
Raet1e		V
Sh3bp2			V
+ 04612: Antigen processing and presentation	0.4	1.9	0	2
Tap1	V
Tap2	V	V
Calr		V		V
Pdia3		V
Hspa5		V		V
Hsp90aa1		V
Psme2				V
Psme2b				V
+ 04660: T cell receptor signaling pathway	2.9	0.3	0.3	1.2
Ikbkg	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Jun	V
Mapk3	V
Mapk8	V
Dlg1	V
Gsk3b	V
Rela		V
Mapk14			V	V
Nfkbia				V
+ 04658: Th1 and Th2 cell differentiation	1.6	0.1	0.4	0.8
Ikbkg	V
Mapk3	V
Mapk8	V
Jun	V
Stat1	V
Rela		V
Mapk14			V	V
Nfkbia				V
+ 04659: Th17 cell differentiation	1.3	0.7	0.8	1.2
Ikbkg	V
Mapk3	V
Mapk8	V
Jun	V
Stat1	V
Rela		V
Stat3		V
Hsp90aa1		V
Mapk14			V	V
Rxra			V	V
Nfkbia				V
+ 04657: IL-17 signaling pathway	1.4	0.8	0.9	1.8
Ikbkg	V
Jun	V
Mapk3	V
Mapk8	V
Gsk3b	V
Rela		V
Hsp90aa1		V
Hsp90b1		V
Mapk14			V	V
Mapk6			V	V
Nfkbia				V
Lcn2				V
+ 04662: B cell receptor signaling pathway	3	1.5	0	0.9
Ikbkg	V
Gsk3b	V
Pik3r1	V			V
Pik3cb	V
Jun	V
Blnk	V
Mapk3	V
Grb2	V	V
Rela		V
Fcgr2b		V
Pik3ap1		V
Nfkbia				V
+ 04664: Fc epsilon RI signaling pathway	2.4	0.2	1.8	1
Map2k6	V		V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Grb2	V	V
Mapk8	V
Mapk14			V	V
Map2k3			V
+ 04666: Fc gamma R-mediated phagocytosis	1.1	0.4	0	1.3
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Pla2g6	V			V
Fcgr2b		V
Asap2		V
Cfl1				V
+ 04670: Leukocyte transendothelial migration	0.4	0.9	0.7	0.6
Pik3r1	V			V
Pik3cb	V
Ctnnb1	V
Cldn1		V
Ctnna1		V
Rapgef4		V
Icam1		V
Mapk14			V	V
Cxcl12			V
+ 04672: Intestinal immune network for IgA production	0	0	0.8	0
Cxcl12			V
+ 04062: Chemokine signaling pathway	2.7	0.8	1	0.2
Cxcl9	V
Pik3r1	V			V
Pik3cb	V
Grb2	V	V
Grk2	V
Grk6	V
Arrb1	V
Adcy6	V
Rasgrp2	V		V
Stat1	V
Mapk3	V
Ikbkg	V
Gsk3b	V
Ccl9		V
Cxcl13		V
Cxcl16		V	V
Stat3		V
Rela		V
Cxcl12			V
Gnb2			V
Nfkbia				V
+ 5.2 Endocrine system	8.9	3.3	3.4	8
+ 04911: Insulin secretion	0.7	0.1	0	1.9
Adcy6	V
Gck	V			V
Kcnn1	V
Rapgef4		V
Creb3l2				V
Atp1b1				V
Kcnn2				V
+ 04910: Insulin signaling pathway	4.8	1	0.2	2.6
Mapk8	V
Mapk3	V
Fasn	V			V
Prkag2	V
Pklr	V
Gys2	V
Acaca	V
Grb2	V	V
Fbp1	V
Pik3r1	V			V
Pik3cb	V
Gsk3b	V
Srebf1	V			V
Rapgef1	V	V
Gck	V			V
Slc2a4	V
Flot1	V
Socs2		V
Exoc7		V
Irs1		V
Phkg2			V	V
Acacb				V
Eif4e2				V
+ 04922: Glucagon signaling pathway	2	0.1	0.8	2.6
Gck	V			V
Gys2	V
Cpt1a	V
Fbp1	V
Acaca	V
Prkag2	V
Sirt1	V		V	V
Gcgr		V
Phkg2			V	V
Creb3l2				V
Acacb				V
Itpr1				V
+ 04923: Regulation of lipolysis in adipocytes	1.7	0.8	0	0.5
Adcy6	V
Pik3r1	V			V
Pik3cb	V
Fabp4	V
Irs1		V
Adora1		V
+ 04920: Adipocytokine signaling pathway	2.3	2.1	1.1	2.1
Cpt1a	V
Prkag2	V
Slc2a4	V
Ikbkg	V
Mapk8	V
Cd36	V
Rela		V
Acsl4		V
Lepr		V
Stat3		V
Irs1		V
Acsl1			V
Rxra			V	V
Nfkbia				V
Acsl3				V
Acacb				V
+ 03320: PPAR signaling pathway	5	2.7	2.1	3.9
Gk	V
Plin2	V			V
Cd36	V
Fabp4	V
Fabp2	V
Pparg	V
Scp2	V	V		V
Acaa1a	V
Acaa1b	V			V
Acadm	V
Cpt1a	V
Acox1	V
Fads2	V
Apoa5	V
Fabp5		V
Cyp4a12b		V
Cyp4a12a		V
Acsl4		V
Apoa2		V
Nr1h3		V
Slc27a5			V
Rxra			V	V
Acsl1			V
Cyp7a1			V
Slc27a1				V
Acsl3				V
Hmgcs1				V
Me1				V
+ 04929: GnRH secretion	2.1	0	0	1.7
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Arrb1	V
Kcnn1	V
Itpr1				V
Kcnn2				V
+ 04912: GnRH signaling pathway	2.3	0.4	1.5	1.3
Adcy6	V
Map2k6	V		V
Mapk3	V
Grb2	V	V
Mapk8	V
Jun	V
Egr1	V			V
Egfr		V
Map2k3			V
Mapk14			V	V
Itpr1				V
+ 04913: Ovarian steroidogenesis	1.6	1.3	1.3	1.1
Hsd3b2	V		V
Cyp17a1	V
Adcy6	V
Acot2	V
Hsd17b2		V
Igf1		V	V
Bmp6		V
Hsd17b7				V
Ldlr				V
+ 04915: Estrogen signaling pathway	1.6	1.1	0.6	0.9
Jun	V
Mapk3	V
Adcy6	V
Pik3r1	V			V
Pik3cb	V
Grb2	V	V
Krt23	V
Egfr		V
Hsp90aa1		V
Hsp90b1		V
Ctsd		V
Esr1			V
Ncoa2			V
Creb3l2				V
Itpr1				V
+ 04914: Progesterone-mediated oocyte maturation	1.9	0.4	0.9	1.3
Adcy6	V
Pik3r1	V			V
Pik3cb	V
Rps6ka1	V			V
Mapk3	V
Mapk8	V
Igf1		V	V
Hsp90aa1		V
Mapk14			V	V
+ 04917: Prolactin signaling pathway	3.6	2.1	1.1	1.6
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Stat1	V
Grb2	V	V
Mapk8	V
Gck	V			V
Cyp17a1	V
Gsk3b	V
Stat3		V
Socs2		V
Ccnd1		V
Rela		V
Mapk14			V	V
Esr1			V
+ 04921: Oxytocin signaling pathway	0.4	0.1	0	1.2
Adcy6	V
Mapk3	V
Prkag2	V
Jun	V
Ccnd1		V
Egfr		V
Itpr1				V
Myl6				V
Rcan1				V
Cdkn1a				V
+ 04926: Relaxin signaling pathway	2.4	0.4	0.6	1.8
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Col3a1	V			V
Adcy6	V
Jun	V
Mapk8	V
Grb2	V	V
Arrb1	V
Rela		V
Egfr		V
Gnb2			V
Mapk14			V	V
Nfkbia				V
Creb3l2				V
+ 04935: Growth hormone synthesis, secretion and action	2.6	1.3	1.7	1.5
Adcy6	V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Gsk3b	V
Stat1	V
Grb2	V	V
Map2k6	V		V
Mapk8	V
Irs1		V
Igf1		V	V
Socs2		V
Stat3		V
Mapk14			V	V
Map2k3			V
Itpr1				V
Creb3l2				V
+ 04918: Thyroid hormone synthesis	0.5	1.1	0	2.7
Adcy6	V
Ttf1	V
Hspa5		V		V
Hsp90b1		V
Pdia4		V		V
Atp1b1				V
Creb3l2				V
Itpr1				V
+ 04919: Thyroid hormone signaling pathway	3	0.5	2.2	2
Pik3r1	V			V
Pik3cb	V
Ctnnb1	V
Gsk3b	V
Stat1	V
Mapk3	V
Rcan2	V
Med16	V
Med14	V
Mdm2	V	V
Atp2a2		V
Ccnd1		V
Thra			V	V
Esr1			V
Rxra			V	V
Ncor1			V
Ncoa2			V
Rcan1				V
Atp1b1				V
+ 04928: Parathyroid hormone synthesis, secretion and action	1.2	0.1	0.3	2.1
Adcy6	V
Pth1r	V
Arrb1	V
Mapk3	V
Egr1	V			V
Egfr		V
Rxra			V	V
Itpr1				V
Creb3l2				V
Cdkn1a				V
+ 04916: Melanogenesis	1.7	0	0.8	0.2
Fzd4	V		V
Fzd8	V
Adcy6	V
Gsk3b	V
Ctnnb1	V
Mapk3	V
Kit			V
Creb3l2				V
+ 04924: Renin secretion	0.1	0.2	0	0.4
Adcy6	V
Adora1		V
Itpr1				V
+ 04614: Renin-angiotensin system	0	0	0	1.5
Nln				V
Enpep				V
+ 04925: Aldosterone synthesis and secretion	0.2	0.1	0.8	1.7
Adcy6	V
Hsd3b2	V		V
Prkd3		V
Atp2b4			V
Itpr1				V
Creb3l2				V
Ldlr				V
Atp1b1				V
+ 04927: Cortisol synthesis and secretion	0.9	0	0.5	1.6
Adcy6	V
Hsd3b2	V		V
Cyp17a1	V
Itpr1				V
Creb3l2				V
Ldlr				V
+ 5.3 Circulatory system	0.7	0.8	0.6	1.3
+ 04260: Cardiac muscle contraction	0.3	0.4	0.4	0.3
Tpm2	V
Cox4i1	V
Atp2a2		V
Tpm1		V
Cox5a			V
Atp1b1				V
+ 04261: Adrenergic signaling in cardiomyocytes	0.4	0.6	0.5	1.2
Tpm2	V
Adcy6	V
Mapk3	V
Ppp2r1b	V
Atp2a2		V
Tpm1		V
Rapgef4		V
Crem		V		V
Mapk14			V	V
Atp2b4			V
Atp1b1				V
Creb3l2				V
+ 04270: Vascular smooth muscle contraction	0.5	0.4	0.2	0.8
Pla2g6	V			V
Mapk3	V
Adcy6	V
Ramp2	V
Cyp4a12b		V
Cyp4a12a		V
Avpr1a		V	V
Myl6				V
Itpr1				V
+ 5.4 Digestive system	3.7	1	2.8	4.9
+ 04970: Salivary secretion	0.1	0	0.4	0.9
Adcy6	V
Atp2b4			V
Itpr1				V
Atp1b1				V
+ 04971: Gastric acid secretion	0.1	0	0	0.9
Adcy6	V
Itpr1				V
Atp1b1				V
+ 04972: Pancreatic secretion	0	0.1	0.3	0.6
Adcy6	V
Atp2a2		V
Atp2b4			V
Itpr1				V
Atp1b1				V
+ 04976: Bile secretion	2.3	0.6	3.4	3.7
Adcy6	V
Abcc3	V
Abcg5	V
Abcg8	V
Abcb1a	V
Aqp8	V			V
Slco1a1		V	V
Ephx1		V
Slc10a1			V
Cyp7a1			V
Nr1h4			V
Slc27a5			V
Rxra			V	V
Atp1b1				V
Nr0b2				V
Kcnn2				V
Ldlr				V
Hmgcr				V
+ 04973: Carbohydrate digestion and absorption	0.8	0	0	1.4
Pik3r1	V			V
Pik3cb	V
Atp1b1				V
+ 04974: Protein digestion and absorption	0.3	0.1	0.3	0.7
Col3a1	V			V
Col27a1	V
Col13a1		V	V
Atp1b1				V
+ 04975: Fat digestion and absorption	3.7	0.4	0.8	0.7
Abcg5	V
Abcg8	V
Cd36	V
Agpat2	V
Dgat1	V
Apoa4	V			V
Fabp2	V
Apob		V	V
+ 04979: Cholesterol metabolism	2.9	0.9	2.1	3.2
Apoa4	V			V
Cd36	V
Lipg	V			V
Vdac1	V
Abcg5	V
Abcg8	V
Apob		V	V
Apoa2		V
Osbpl5			V
Cyp7a1			V
Ldlr				V
Pcsk9				V
Lipa				V
+ 04977: Vitamin digestion and absorption	1.4	0.7	1	1
Apoa4	V			V
Tcn2	V
Apob		V	V
+ 04978: Mineral absorption	0.2	0.3	0.6	2.5
Steap2	V
Slc39a4		V
Atp2b4			V
LOC100862446				V
Ftl1				V
Fth1				V
Atp1b1				V
+ 5.5 Excretory system	2.6	1.3	1.5	2.4
+ 04962: Vasopressin-regulated water reabsorption	0.3	1	0.7	1.4
Adcy6	V
Arhgdia		V
Dynll1		V
Dctn6			V
Creb3l2				V
Dync1li2				V
+ 04960: Aldosterone-regulated sodium reabsorption	2.2	1.1	0.8	1.5
Scnn1a	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Irs1		V
Igf1		V	V
Atp1b1				V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	1.1	0.7	1.9	0.5
Pth1r	V
Clta	V
Adcy6	V
Cltc		V
Ap2a1		V
Atp2b4			V
Ap2b1			V
Esr1			V
Atp1b1				V
+ 04964: Proximal tubule bicarbonate reclamation	2.2	0	0	1.9
Gls2	V			V
Slc38a3	V
Slc25a10	V
Atp1b1				V
+ 04966: Collecting duct acid secretion	0	0	0	0
+ 5.6 Nervous system	2.9	1.4	2.1	2.8
+ 04724: Glutamatergic synapse	1.5	0	0.3	0.6
Adcy6	V
Slc38a3	V
Gls2	V			V
Glul	V
Grk2	V
Mapk3	V
Gnb2			V
Itpr1				V
+ 04727: GABAergic synapse	1	0	0.9	0.3
Adcy6	V
Glul	V
Gls2	V			V
Slc38a3	V
Slc6a12			V
Gnb2			V
+ 04725: Cholinergic synapse	0.8	0	0.2	1.1
Adcy6	V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Gnb2			V
Itpr1				V
Creb3l2				V
+ 04728: Dopaminergic synapse	0.6	0.4	1	0.9
Maob	V
Gsk3b	V
Mapk8	V
Ppp2r1b	V
Ddc		V
Comt		V
Arntl		V
Gnb2			V
Ppp1r1b			V
Mapk14			V	V
Itpr1				V
Creb3l2				V
+ 04726: Serotonergic synapse	0.9	1.1	1.1	0.9
Maob	V
Cyp2c50	V			V
Cyp2c39	V
Cyp2d26	V
Mapk3	V
Ddc		V
Cyp2c40		V
Cyp2c70		V	V
Cyp2c68		V
Cyp2c55		V
Gnb2			V
Cyp2c54			V
Itpr1				V
Kcnn2				V
+ 04720: Long-term potentiation	0.5	0	0	1
Rps6ka1	V			V
Mapk3	V
Itpr1				V
+ 04730: Long-term depression	0.6	0.3	0.6	0.5
Mapk3	V
Ppp2r1b	V
Igf1		V	V
Itpr1				V
+ 04723: Retrograde endocannabinoid signaling	0.6	0	1.3	1.1
Adcy6	V
Mapk3	V
Mapk8	V
Ndufs8	V
Ndufa11	V			V
Gnb2			V
Mapk14			V	V
Ndufs2			V	V
Ndufab1			V
Itpr1				V
+ 04721: Synaptic vesicle cycle	0.1	0.5	1	0
Clta	V
Cltc		V
Ap2a1		V
Ap2b1			V
Slc6a12			V
+ 04722: Neurotrophin signaling pathway	2.5	2.1	0.2	2.4
Pik3r1	V			V
Pik3cb	V
Grb2	V	V
Mapk3	V
Rps6ka1	V			V
Rapgef1	V	V
Gsk3b	V
Mapk8	V
Jun	V
Rela		V
Kidins220		V
Irs1		V
Arhgdia		V
Irak2		V
Mapk14			V	V
Nfkbia				V
Irak1				V
Ywhae				V
+ 5.7 Sensory system	2	1	1.5	0.9
+ 04744: Phototransduction	0	0	0	0
+ 04740: Olfactory transduction	0.9	0	0	0
Arrb1	V
Grk2	V
+ 04742: Taste transduction	0.7	0	0.4	0
Scnn1a	V
P2ry1	V
Adcy6	V
P2ry4			V
+ 04750: Inflammatory mediator regulation of TRP channels	2.4	2	2.6	1.9
Pla2g6	V			V
Adcy6	V
Mapk8	V
Pik3r1	V			V
Pik3cb	V
Cyp2c50	V			V
Cyp2c39	V
Map2k6	V		V
Kng1	V
Cyp2c40		V
Cyp4a12b		V
Cyp2c70		V	V
Cyp4a12a		V
Cyp2c68		V
Cyp2c55		V
Igf1		V	V
Mapk14			V	V
Cyp2c54			V
Map2k3			V
Itpr1				V
+ 5.8 Development and regeneration	3.4	0.4	1.6	1.2
+ 04360: Axon guidance	1.7	0.1	1.6	0.3
Mapk3	V
Robo1	V
Ngef	V		V
Unc5b	V
Sema4g	V	V
Sema5b	V
Pik3r1	V			V
Pik3cb	V
Gsk3b	V
Nrp1		V
Ephb4			V
Met			V
Cxcl12			V
Rhod			V
Cfl1				V
+ 04380: Osteoclast differentiation	3.1	0.5	0.6	1.4
Ikbkg	V
Map2k6	V		V
Mapk8	V
Stat1	V
Pik3r1	V			V
Pik3cb	V
Jun	V
Blnk	V
Pparg	V
Grb2	V	V
Mapk3	V
Rela		V
Fcgr2b		V
Mapk14			V	V
Nfkbia				V
Sirpa				V
+ 5.9 Aging	3.5	2.4	1.5	2.5
+ 04211: Longevity regulating pathway	2.3	2.2	0.9	2.4
Akt1s1	V	V
Pik3r1	V			V
Pik3cb	V
Adcy6	V
Prkag2	V
Sirt1	V		V	V
Pparg	V
Igf1		V	V
Irs1		V
Rela		V
Rb1cc1		V
Atg13		V
Creb3l2				V
Eif4e2				V
Sesn1				V
+ 04213: Longevity regulating pathway - multiple species	2.6	1.3	1.2	1.1
Akt1s1	V	V
Pik3r1	V			V
Pik3cb	V
Adcy6	V
Prkag2	V
Sirt1	V		V	V
Igf1		V	V
Irs1		V
+ 5.10 Environmental adaptation	1.3	0.4	3.1	1.7
+ 04710: Circadian rhythm	0.5	0.6	2.6	0.8
Prkag2	V
Arntl		V
Per3			V
Cry1			V
Cry2			V
Nr1d1				V
+ 04713: Circadian entrainment	0.2	0	0.8	0.2
Mapk3	V
Adcy6	V
Gnb2			V
Per3			V
Itpr1				V
+ 04714: Thermogenesis	1.5	0.1	1.9	1.9
Fgf21	V			V
Adcy6	V
Pparg	V
Cpt1a	V
Rps6ka1	V			V
Akt1s1	V	V
Grb2	V	V
Prkag2	V
Cox4i1	V
Ndufs8	V
Ndufa11	V			V
Acsl4		V
Mapk14			V	V
Arid1b			V
Acsl1			V
Map2k3			V
Cox5a			V
Ndufs2			V	V
Ndufab1			V
Creb3l2				V
Acsl3				V
Atp5d				V
+ 6. Human Diseases	11.7	8.7	6.1	7.4
+ 6.1 Cancer: overview	6.5	5.3	4.5	4.8
+ 05200: Pathways in cancer	2.4	1.6	2	1.1
Ctnnb1	V
Itga3	V
Fzd4	V		V
Fzd8	V
Pik3r1	V			V
Pik3cb	V
Gsk3b	V
Ikbkg	V
Mdm2	V	V
Stat1	V
Grb2	V	V
Mapk8	V
Jun	V
Pparg	V
Fas	V
Bid	V
Mapk3	V
Fgf21	V			V
Adcy6	V
Rasgrp2	V		V
Nfe2l2	V
Nqo1	V
Gstt3	V
Gsta3	V
Gstt2	V
Kng1	V
Cdh1		V
Ctnna1		V
Egfr		V
Igf1		V	V
Hsp90aa1		V
Hsp90b1		V
Stat3		V
Rela		V
Ccnd1		V
Elob		V
Gstp2		V
Gstp1		V
Dapk3		V
Gsta2		V
Gstm1		V
Gstm3		V
Txnrd1		V
Lamb1			V
Pten			V
Kit			V
Met			V
Arnt			V
Rxra			V	V
Fgf1			V
Gnb2			V
Cxcl12			V
Esr1			V
Nfkbia				V
Cul2				V
Mlh1				V
Zbtb16				V
Cdkn1a				V
Flt3l				V
Gsta1				V
Gstm4				V
+ 05202: Transcriptional misregulation in cancer	0.2	2.6	2	1.7
Pparg	V
Mdm2	V	V
Dusp6	V			V
Hpgd	V
Igf1		V	V
H3c14		V
H3c7		V
H3c3		V
H3c4		V
H3c2		V
H3c6		V
H3c13		V
H3c15		V
Rela		V
Tfe3			V
Met			V
Rxra			V	V
Ncor1			V
Hhex			V
Ddit3				V
Cdkn1a				V
Slc45a3				V
Zbtb16				V
+ 05206: MicroRNAs in cancer	2.2	2.3	1.3	2.8
Pik3r1	V			V
Pik3cb	V
Sirt1	V		V	V
Vim	V			V
Gls2	V			V
Abcb1a	V
Mapk3	V
Grb2	V	V
Mdm2	V	V
Bmf	V
Tpm1		V
Ccnd1		V
Foxp1		V
Egfr		V
Stat3		V
Irs1		V
Itga5		V
Pten			V
Met			V
Ezh2			V
Dnmt3a				V
Pdcd4				V
Slc45a3				V
Cdkn1a				V
+ 05205: Proteoglycans in cancer	2	1.4	1.4	1.6
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Grb2	V	V
Mdm2	V	V
Ctnnb1	V
Dcn	V
Fas	V
Fzd4	V		V
Fzd8	V
Gpc1	V
Stat3		V
Ccnd1		V
Igf1		V	V
Sdc4		V
Itga5		V
Egfr		V
Esr1			V
Met			V
Mapk14			V	V
Itpr1				V
Cttn				V
Pdcd4				V
Cdkn1a				V
+ 05204: Chemical carcinogenesis	3	5.6	2	1.8
Cyp2c50	V			V
Cyp2c39	V
Gstt3	V
Gsta3	V
Gstt2	V
Gstk1	V
Hsd11b1	V
Kyat3	V
Kyat1	V
Cyp1a2		V
Cyp2c40		V
Cyp2c70		V	V
Cyp2c68		V
Cyp2c55		V
Ugt2b38		V
Ugt2b37		V
Ugt1a9		V
Gsta2		V
Gstm1		V
Gstm3		V
Gstp2		V
Gstp1		V
Ephx1		V
Cyp3a11		V		V
Cyp2c54			V
Ugt2b34			V
Arnt			V
Gsta1				V
Gstm4				V
+ 05203: Viral carcinogenesis	1.5	0.9	0	1.8
Dlg1	V
Psmc1	V
Jun	V
Ikbkg	V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Vac14	V
Mdm2	V	V
Grb2	V	V
Stat3		V
Rela		V
Ccnd1		V
Gtf2b		V
Ddx3x		V
Gtf2a2			V
Creb3l2				V
Mrps18b				V
Ywhae				V
Cdkn1a				V
Nfkbia				V
Irf7				V
+ 05230: Central carbon metabolism in cancer	1.9	0.2	2.4	1.6
Gck	V			V
Gls2	V			V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Egfr		V
Sirt3			V
Kit			V
Met			V
Pten			V
+ 05231: Choline metabolism in cancer	3.7	0.3	0.3	0.2
Mapk8	V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Grb2	V	V
Slc22a3	V
Chkb	V
Chpt1	V
Pcyt1a	V
Lypla1	V
Jun	V
Egfr		V
Gpcpd1			V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	2.4	0.9	2.1	1.9
Ikbkg	V
Pik3r1	V			V
Pik3cb	V
Jun	V
Mapk3	V
Stat1	V
Map2k6	V		V
Rela		V
Egfr		V
Stat3		V
Map2k3			V
Mapk14			V	V
Pten			V
Nfkbia				V
Csnk2b				V
+ 6.2 Cancer: specific types	8.6	6.5	3.9	5.7
+ 05210: Colorectal cancer	2.8	0.9	0	1.4
Pik3r1	V			V
Pik3cb	V
Mapk8	V
Mapk3	V
Jun	V
Gsk3b	V
Ctnnb1	V
Grb2	V	V
Ccnd1		V
Egfr		V
Mlh1				V
Cdkn1a				V
+ 05212: Pancreatic cancer	2.2	1.5	0	0.9
Pik3r1	V			V
Pik3cb	V
Ikbkg	V
Mapk3	V
Mapk8	V
Stat1	V
Rela		V
Stat3		V
Egfr		V
Ccnd1		V
Cdkn1a				V
+ 05225: Hepatocellular carcinoma	3.1	2.1	1.2	1
Mapk3	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Ctnnb1	V
Gsk3b	V
Fzd4	V		V
Fzd8	V
Nfe2l2	V
Nqo1	V
Gstt3	V
Gsta3	V
Gstt2	V
Egfr		V
Ccnd1		V
Gsta2		V
Gstm1		V
Gstm3		V
Gstp2		V
Gstp1		V
Txnrd1		V
Pten			V
Met			V
Arid1b			V
Cdkn1a				V
Gsta1				V
Gstm4				V
+ 05226: Gastric cancer	2.4	1	1.4	1.7
Mapk3	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Ctnnb1	V
Gsk3b	V
Fzd4	V		V
Fzd8	V
Fgf21	V			V
Abcb1a	V
Ccnd1		V
Cdh1		V
Ctnna1		V
Egfr		V
Met			V
Fgf1			V
Rxra			V	V
Cdkn1a				V
Mlh1				V
+ 05214: Glioma	1.8	2	1.1	0.9
Grb2	V	V
Mapk3	V
Pik3r1	V			V
Pik3cb	V
Mdm2	V	V
Igf1		V	V
Egfr		V
Ccnd1		V
Pten			V
Cdkn1a				V
+ 05216: Thyroid cancer	1.6	1.2	0.8	1.5
Pparg	V
Mapk3	V
Ctnnb1	V
Cdh1		V
Ccnd1		V
Rxra			V	V
Cdkn1a				V
+ 05221: Acute myeloid leukemia	2.3	1.6	0.5	1.6
Ikbkg	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Dusp6	V			V
Rela		V
Stat3		V
Ccnd1		V
Kit			V
Zbtb16				V
+ 05220: Chronic myeloid leukemia	2.2	1.5	0	1.5
Mdm2	V	V
Ikbkg	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Rela		V
Ccnd1		V
Nfkbia				V
Cdkn1a				V
+ 05217: Basal cell carcinoma	1.6	0	0.5	0.5
Fzd4	V		V
Fzd8	V
Ctnnb1	V
Gsk3b	V
Cdkn1a				V
+ 05218: Melanoma	1.8	2.1	2.3	1.6
Fgf21	V			V
Mdm2	V	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Cdh1		V
Ccnd1		V
Egfr		V
Igf1		V	V
Pten			V
Met			V
Fgf1			V
Cdkn1a				V
+ 05211: Renal cell carcinoma	2.4	1.1	1.8	1.6
Rapgef1	V	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Jun	V
Mapk3	V
Elob		V
Arnt			V
Met			V
Tfe3			V
Cul2				V
Cdkn1a				V
+ 05219: Bladder cancer	0.9	2.9	0	1.5
Mdm2	V	V
Mapk3	V
Egfr		V
Cdh1		V
Dapk3		V
Ccnd1		V
Tymp				V
Cdkn1a				V
+ 05215: Prostate cancer	2.6	3.7	1.4	1.7
Mdm2	V	V
Ctnnb1	V
Ikbkg	V
Grb2	V	V
Gsk3b	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Rela		V
Ccnd1		V
Egfr		V
Igf1		V	V
Hsp90aa1		V
Hsp90b1		V
Gstp2		V
Gstp1		V
Srd5a2			V
Pten			V
Nfkbia				V
Cdkn1a				V
Creb3l2				V
+ 05213: Endometrial cancer	2.7	2.4	0.6	1.8
Ctnnb1	V
Gsk3b	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Ctnna1		V
Cdh1		V
Egfr		V
Ccnd1		V
Pten			V
Mlh1				V
Cdkn1a				V
+ 05224: Breast cancer	2.5	0.6	2.4	0.8
Mapk3	V
Grb2	V	V
Jun	V
Pik3r1	V			V
Pik3cb	V
Ctnnb1	V
Gsk3b	V
Fzd4	V		V
Fzd8	V
Fgf21	V			V
Egfr		V
Igf1		V	V
Ccnd1		V
Esr1			V
Pten			V
Kit			V
Fgf1			V
Cdkn1a				V
+ 05222: Small cell lung cancer	1	0.4	1.4	1.8
Itga3	V
Pik3r1	V			V
Pik3cb	V
Ikbkg	V
Ccnd1		V
Rela		V
Rxra			V	V
Pten			V
Lamb1			V
Nfkbia				V
Cdkn1a				V
+ 05223: Non-small cell lung cancer	1.5	1.7	0.5	1.7
Pik3r1	V			V
Pik3cb	V
Grb2	V	V
Mapk3	V
Ccnd1		V
Egfr		V
Stat3		V
Rxra			V	V
Cdkn1a				V
+ 6.12 Drug resistance: antineoplastic	5.1	3.3	2.1	2.4
+ 01521: EGFR tyrosine kinase inhibitor resistance	1.7	1.5	1.6	0.9
Gsk3b	V
Grb2	V	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Egfr		V
Stat3		V
Igf1		V	V
Pten			V
Met			V
Eif4e2				V
+ 01524: Platinum drug resistance	3.8	2.4	0	2.6
Bid	V
Fas	V
Gstt3	V
Gsta3	V
Gstt2	V
Pik3r1	V			V
Pik3cb	V
Mapk3	V
Mdm2	V	V
Rev3l	V
Gsta2		V
Gstm1		V
Gstm3		V
Gstp2		V
Gstp1		V
Gsta1				V
Gstm4				V
Mlh1				V
Cdkn1a				V
+ 01523: Antifolate resistance	1.9	0.6	0	0
Abcc3	V
Dhfr	V
Ikbkg	V
Rela		V
+ 01522: Endocrine resistance	2.7	2.1	2.6	1.3
Mapk3	V
Grb2	V	V
Adcy6	V
Pik3r1	V			V
Pik3cb	V
Mapk8	V
Mdm2	V	V
Jun	V
Egfr		V
Ccnd1		V
Igf1		V	V
Bik		V	V
Esr1			V
Mapk14			V	V
Ncor1			V
Cdkn1a				V