• Score Type:
• Meta Z-score
• Z-score
• No. of Genes

HisBIM: A Hierarchical System Biology Model

System/Subsystem/Pathway	Z-score
	BLCA	BRCA	CHOL	COAD	HNSC	KICH	KIRC	KIRP	LIHC	LUAD	LUSC	PRAD	READ	UCEC
	33/32	37/36	32/31	27/26	23/22	18/17	23/22	19/18	36/35	34/33	30/29	15/14	20/19	36/35
+ 1. Metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.0 Global and overview maps	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 01100: Metabolic pathways	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 01200: Carbon metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 01210: 2-Oxocarboxylic acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 01212: Fatty acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 01230: Biosynthesis of amino acids	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.1 Carbohydrate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00010: Glycolysis / Gluconeogenesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00020: Citrate cycle (TCA cycle)	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00030: Pentose phosphate pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00040: Pentose and glucuronate interconversions	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00051: Fructose and mannose metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00052: Galactose metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00053: Ascorbate and aldarate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00500: Starch and sucrose metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00520: Amino sugar and nucleotide sugar metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00620: Pyruvate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00630: Glyoxylate and dicarboxylate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00640: Propanoate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00650: Butanoate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00562: Inositol phosphate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.2 Energy metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00190: Oxidative phosphorylation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00910: Nitrogen metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00920: Sulfur metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.3 Lipid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00061: Fatty acid biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00062: Fatty acid elongation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00071: Fatty acid degradation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00072: Synthesis and degradation of ketone bodies	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00100: Steroid biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00120: Primary bile acid biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00140: Steroid hormone biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00561: Glycerolipid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00564: Glycerophospholipid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00565: Ether lipid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00600: Sphingolipid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00590: Arachidonic acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00591: Linoleic acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00592: alpha-Linolenic acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 01040: Biosynthesis of unsaturated fatty acids	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.4 Nucleotide metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00230: Purine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00240: Pyrimidine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.5 Amino acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00250: Alanine, aspartate and glutamate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00260: Glycine, serine and threonine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00270: Cysteine and methionine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00280: Valine, leucine and isoleucine degradation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00290: Valine, leucine and isoleucine biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00310: Lysine degradation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00220: Arginine biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00330: Arginine and proline metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00340: Histidine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00350: Tyrosine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00360: Phenylalanine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00380: Tryptophan metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.6 Metabolism of other amino acids	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00410: beta-Alanine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00430: Taurine and hypotaurine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00440: Phosphonate and phosphinate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00450: Selenocompound metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00471: D-Glutamine and D-glutamate metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00480: Glutathione metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.7 Glycan biosynthesis and metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00510: N-Glycan biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00512: Mucin type O-glycan biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00515: Mannose type O-glycan biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00514: Other types of O-glycan biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00531: Glycosaminoglycan degradation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00511: Other glycan degradation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.8 Metabolism of cofactors and vitamins	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00730: Thiamine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00740: Riboflavin metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00750: Vitamin B6 metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00760: Nicotinate and nicotinamide metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00770: Pantothenate and CoA biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00780: Biotin metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00785: Lipoic acid metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00790: Folate biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00670: One carbon pool by folate	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00830: Retinol metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00860: Porphyrin and chlorophyll metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.9 Metabolism of terpenoids and polyketides	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00900: Terpenoid backbone biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.10 Biosynthesis of other secondary metabolites	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00232: Caffeine metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 1.11 Xenobiotics biodegradation and metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00980: Metabolism of xenobiotics by cytochrome P450	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00982: Drug metabolism - cytochrome P450	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00983: Drug metabolism - other enzymes	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 2. Genetic Information Processing	2.5	2.1	0.6	1.3	0.7	0	0.7	0.3	1.5	2.5	1.3	0.3	0.7	2.3
+ 2.1 Transcription	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03020: RNA polymerase	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03022: Basal transcription factors	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03040: Spliceosome	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 2.2 Translation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03010: Ribosome	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 00970: Aminoacyl-tRNA biosynthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03013: RNA transport	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03015: mRNA surveillance pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03008: Ribosome biogenesis in eukaryotes	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 2.3 Folding, sorting and degradation	0.5	0.5	0.5	0.5	0.6	0	0.6	0.6	0.5	0.5	0.5	0.6	0	0.5
+ 03060: Protein export	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04141: Protein processing in endoplasmic reticulum	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04130: SNARE interactions in vesicular transport	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04120: Ubiquitin mediated proteolysis	1.3	1.2	1.3	1.4	1.5	0	1.5	1.6	1.2	1.3	1.3	1.7	0	1.2
CDC20	V	V	V	V	V		V	V	V	V	V	V		V
+ 04122: Sulfur relay system	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03050: Proteasome	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03018: RNA degradation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 2.4 Replication and repair	4.4	3.7	0.7	2	0.8	0	0.8	0	2.5	4.4	2	0	1.3	4
+ 03030: DNA replication	5.9	4.1	1.9	5.3	2.1	0	2.1	0	6.6	5.9	5.2	0	3.4	5
PCNA	V	V								V				V
MCM5	V						V		V
MCM2	V	V	V	V	V				V	V	V		V	V
MCM4	V	V		V					V	V	V			V
MCM7	V			V					V	V	V		V	V
MCM3				V					V
MCM6									V	V	V
+ 03410: Base excision repair	1.9	1.9	0	0	0	0	0	0	0	1.9	0	0	0	1.9
PCNA	V	V								V				V
+ 03420: Nucleotide excision repair	1.8	1.7	0	0	0	0	0	0	0	1.8	0	0	0	1.7
PCNA	V	V								V				V
+ 03430: Mismatch repair	2.1	2	0	0	0	0	0	0	0	2.1	0	0	0	2
PCNA	V	V								V				V
+ 03440: Homologous recombination	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03450: Non-homologous end-joining	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03460: Fanconi anemia pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 3. Environmental Information Processing	1	3.1	2.2	0.9	1.6	1.6	1.6	1	1.1	0.9	1.1	0.9	0.6	2.3
+ 3.1 Membrane transport	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 02010: ABC transporters	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 3.2 Signal transduction	1.4	5	3.4	1.1	2.3	2.2	2.3	1.3	1.5	1.2	1.5	0.9	0.5	3.5
+ 04010: MAPK signaling pathway	0	2.4	0.9	0	1.1	1.2	1.1	0	0	0	0	0	0	1.6
EGFR		V	V
ERBB2		V					V							V
MET		V
ERBB4					V	V
ERBB3														V
+ 04012: ErbB signaling pathway	0	2.5	1.5	0	1.7	1.8	1.7	0	0	0	0	0	0	2.6
ERBB2		V					V							V
EGFR		V	V
ERBB4					V	V
ERBB3														V
+ 04014: Ras signaling pathway	0	1.8	1	0	0	0	0	0	0	0	0	0	0	0
EGFR		V	V
MET		V
+ 04015: Rap1 signaling pathway	0	1.9	1.1	0	0	0	0	0	0	0	0	0	0	1
EGFR		V	V
MET		V
CDH1														V
+ 04310: Wnt signaling pathway	0	1.1	0	0	0	0	0	0	0	0	0	0	0	0
TCF7L2		V
+ 04330: Notch signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04340: Hedgehog signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04350: TGF-beta signaling pathway	1.5	0	0	0	0	0	0	0	1.4	0	0	0	0	0
RBL1	V								V
+ 04390: Hippo signaling pathway	0	1.2	1.2	0	1.4	0	0	0	0	0	0	0	0	1.2
TCF7L2		V
CTNNA1			V
CTNNA3					V
CDH1														V
+ 04392: Hippo signaling pathway - multiple species	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04370: VEGF signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04371: Apelin signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	1.2
CDH1														V
+ 04064: NF-kappa B signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04668: TNF signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04066: HIF-1 signaling pathway	0	2.4	1.4	0	0	0	1.6	0	0	0	0	0	0	1.4
EGFR		V	V
ERBB2		V					V							V
+ 04068: FoxO signaling pathway	3.2	3.9	4	3.4	3.5	2.8	2.6	2.7	3.1	3.2	3.3	2.9	1.5	3.1
CCNB1	V	V	V	V	V				V	V	V			V
CCNB2	V	V	V		V	V	V	V	V	V	V	V		V
PLK1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
EGFR		V	V
CDK2				V
+ 04020: Calcium signaling pathway	0	2	1.1	0	1.3	1.4	1.3	0	0	0	0	0	0	2
EGFR		V	V
ERBB2		V					V							V
ERBB4					V	V
ERBB3														V
+ 04070: Phosphatidylinositol signaling system	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04072: Phospholipase D signaling pathway	0	1.2	1.2	0	0	0	0	0	0	0	1.3	0	0	0
EGFR		V	V
FYN											V
+ 04071: Sphingolipid signaling pathway	0	0	0	0	0	0	0	0	0	0	1.4	0	0	0
FYN											V
+ 04024: cAMP signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04022: cGMP-PKG signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04151: PI3K-Akt signaling pathway	0.8	3.5	2.4	0.9	1	2.1	1.9	2	1.5	1.5	0	0	1	2.2
CCNE2	V	V	V				V	V	V	V
EGFR		V	V
ERBB2		V					V							V
MET		V
CCNE1		V	V			V		V	V	V			V	V
CDK2				V
ERBB4					V	V
ERBB3														V
+ 04152: AMPK signaling pathway	1.3	1.3	1.4	1.4	1.5	1.6	1.5	1.6	1.3	1.3	1.4	1.7	0	1.3
CCNA2	V	V	V	V	V	V	V	V	V	V	V	V		V
+ 04150: mTOR signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 3.3 Signaling molecules and interaction	0.4	0.4	0.4	0.4	0.5	0.6	0.5	0.5	0.4	0.4	0.4	0.6	0.5	0.4
+ 04080: Neuroactive ligand-receptor interaction	0.8	0.7	0.8	0.9	1	1.1	1	1.1	0.7	0.8	0.8	1.2	1.1	0.7
CHRNA9	V	V	V	V	V	V	V	V	V	V	V	V	V	V
+ 04060: Cytokine-cytokine receptor interaction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04061: Viral protein interaction with cytokine and cytokine receptor	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04512: ECM-receptor interaction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 4. Cellular Processes	7.9	10.7	9.9	6.9	6.3	5.2	6.9	5.8	8	8.3	8.4	4.4	5.7	9
+ 4.1 Transport and catabolism	0.6	0.9	1.8	0.7	0	0.7	0.7	0.7	0.6	0.6	0.4	0	0.7	0.6
+ 04144: Endocytosis	0	0.9	1.9	0	0	0	0	0	0	0	1	0	0	0
EGFR		V	V
UBB			V
WAS											V
+ 04145: Phagosome	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04142: Lysosome	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04146: Peroxisome	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04140: Autophagy - animal	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04136: Autophagy - other	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04137: Mitophagy - animal	1.6	1.6	2.8	1.7	0	1.9	1.8	1.9	1.6	1.6	0	0	1.9	1.6
E2F1	V	V	V	V		V	V	V	V	V			V	V
UBB			V
+ 4.2 Cell growth and death	13.9	13.6	12.8	12.4	10.5	9.7	10.6	10.9	14.8	14.8	11.5	8.7	9.9	13.7
+ 04110: Cell cycle	17.5	16.2	14.5	15.7	12.2	11.7	13.2	12.7	18.4	17.8	14.8	11	13.1	16.7
MCM2	V	V	V	V	V				V	V	V		V	V
MCM4	V	V		V					V	V	V			V
MCM5	V						V		V
MCM7	V			V					V	V	V		V	V
ORC6	V	V	V	V	V	V	V	V	V	V	V		V	V
ORC1	V	V			V		V		V	V	V			V
CDK1	V	V	V	V	V				V	V	V		V	V
BUB1B	V	V	V	V	V	V	V	V	V	V	V	V	V	V
PCNA	V	V								V				V
PLK1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
DBF4	V	V								V	V		V	V
MAD2L1	V	V	V	V	V				V	V	V			V
BUB1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CHEK1	V	V		V	V				V	V	V			V
PKMYT1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
PTTG1	V	V	V	V		V	V	V	V	V		V	V	V
ESPL1	V	V	V	V					V	V	V	V	V	V
CDC7	V	V		V					V	V				V
CDC20	V	V	V	V	V		V	V	V	V	V	V		V
CDC25C	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CDC45	V	V	V	V		V	V	V	V	V	V	V	V	V
CDC6	V	V	V	V	V		V	V	V	V	V		V	V
CDC25A	V	V	V	V					V	V	V		V	V
CCNB1	V	V	V	V	V				V	V	V			V
CCNB2	V	V	V		V	V	V	V	V	V	V	V		V
CCNA2	V	V	V	V	V	V	V	V	V	V	V	V		V
CCNE2	V	V	V				V	V	V	V
TTK	V	V	V	V	V	V	V	V	V	V	V	V	V	V
RBL1	V								V
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
CCNE1		V	V			V		V	V	V			V	V
CDKN2C			V						V
MCM3				V					V
CDK2				V
SMC1B						V			V
CHEK2							V			V				V
MCM6									V	V	V
+ 04114: Oocyte meiosis	8.9	9.2	9.5	8.7	7.8	7.5	7.2	8.1	9.7	9.3	8	7.8	7.4	8.7
CDK1	V	V	V	V	V				V	V	V		V	V
MAD2L1	V	V	V	V	V				V	V	V			V
CCNB2	V	V	V		V	V	V	V	V	V	V	V		V
PKMYT1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CDC20	V	V	V	V	V		V	V	V	V	V	V		V
PTTG1	V	V	V	V		V	V	V	V	V		V	V	V
CCNB1	V	V	V	V	V				V	V	V			V
CCNE2	V	V	V				V	V	V	V
CDC25C	V	V	V	V	V	V	V	V	V	V	V	V	V	V
PLK1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
ESPL1	V	V	V	V					V	V	V	V	V	V
BUB1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CCNE1		V	V			V		V	V	V			V	V
CDK2				V
SMC1B						V			V
+ 04210: Apoptosis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04215: Apoptosis - multiple species	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04216: Ferroptosis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04217: Necroptosis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04115: p53 signaling pathway	5.3	5.9	5.3	4.7	4.8	3.1	4	4.1	5.9	6.6	4.6	2	3.1	5.9
CHEK1	V	V		V	V				V	V	V			V
CCNE2	V	V	V				V	V	V	V
CDK1	V	V	V	V	V				V	V	V		V	V
CCNB1	V	V	V	V	V				V	V	V			V
CCNB2	V	V	V		V	V	V	V	V	V	V	V		V
CCNE1		V	V			V		V	V	V			V	V
CDK2				V
CHEK2							V			V				V
+ 04218: Cellular senescence	7.5	7.3	7	6.1	4.9	5.2	5.6	5.8	7.9	8	5.3	3.7	4.3	7.4
CCNE2	V	V	V				V	V	V	V
RBL1	V								V
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
CCNA2	V	V	V	V	V	V	V	V	V	V	V	V		V
CDC25A	V	V	V	V					V	V	V		V	V
CHEK1	V	V		V	V				V	V	V			V
CDK1	V	V	V	V	V				V	V	V		V	V
CCNB1	V	V	V	V	V				V	V	V			V
CCNB2	V	V	V		V	V	V	V	V	V	V	V		V
CCNE1		V	V			V		V	V	V			V	V
CDK2				V
CHEK2							V			V				V
+ 4.3 Cellular community - eukaryotes	1.2	5.9	4	0.7	2.1	0	2.5	0	0.6	1.2	3.8	0	0.8	3.7
+ 04510: Focal adhesion	0	2.7	1.1	0	0	0	1.3	0	0	0	1.1	0	0	1
EGFR		V	V
ERBB2		V					V							V
MET		V
FYN											V
+ 04520: Adherens junction	0	5.9	5.3	0	3	0	3	0	0	0	4.6	0	0	3.6
TCF7L2		V
EGFR		V	V
ERBB2		V					V							V
MET		V
WASF3		V
NECTIN3		V
CTNNA1			V
FER			V
PTPRF			V
PTPRM			V								V
CTNNA3					V
SORBS1					V						V
LMO7							V
FYN											V
WAS											V
CDH1														V
NECTIN4														V
+ 04530: Tight junction	1.2	2.1	0	0	0	0	1.4	0	0	1.1	1.2	0	0	2.1
PCNA	V	V								V				V
ERBB2		V					V							V
WAS											V
+ 04540: Gap junction	1.5	2.5	2.6	1.6	1.7	0	0	0	1.4	1.5	1.5	0	1.7	1.4
CDK1	V	V	V	V	V				V	V	V		V	V
EGFR		V	V
+ 04550: Signaling pathways regulating pluripotency of stem cells	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 4.5 Cell motility	0	1	1.1	0	0	0	0	0	0	0	1.1	0	0	0
+ 04810: Regulation of actin cytoskeleton	0	1	1.1	0	0	0	0	0	0	0	1.1	0	0	0
EGFR		V	V
WAS											V
+ 5. Organismal Systems	0.6	1.4	1.2	0.6	0.9	0.4	0.4	0.4	0.6	0.6	2.1	0.4	0.4	0.6
+ 5.1 Immune system	0	0.3	0.3	0	0.3	0	0	0	0	0	1.9	0	0	0
+ 04640: Hematopoietic cell lineage	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04610: Complement and coagulation cascades	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04611: Platelet activation	0	0	0	0	0	0	0	0	0	0	1.4	0	0	0
FYN											V
+ 04620: Toll-like receptor signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04621: NOD-like receptor signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04622: RIG-I-like receptor signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04623: Cytosolic DNA-sensing pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04625: C-type lectin receptor signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04650: Natural killer cell mediated cytotoxicity	0	0	0	0	0	0	0	0	0	0	1.3	0	0	0
FYN											V
+ 04612: Antigen processing and presentation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04660: T cell receptor signaling pathway	0	0	0	0	0	0	0	0	0	0	1.5	0	0	0
FYN											V
+ 04658: Th1 and Th2 cell differentiation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04659: Th17 cell differentiation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04657: IL-17 signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04662: B cell receptor signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04664: Fc epsilon RI signaling pathway	0	0	0	0	0	0	0	0	0	0	1.7	0	0	0
FYN											V
+ 04666: Fc gamma R-mediated phagocytosis	0	1.4	0	0	0	0	0	0	0	0	1.5	0	0	0
WASF3		V
WAS											V
+ 04670: Leukocyte transendothelial migration	0	0	1.4	0	1.6	0	0	0	0	0	0	0	0	0
CTNNA1			V
CTNNA3					V
+ 04672: Intestinal immune network for IgA production	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04062: Chemokine signaling pathway	0	0	0	0	0	0	0	0	0	0	1.2	0	0	0
WAS											V
+ 5.2 Endocrine system	1.8	3.4	3.5	1.8	2.5	1.4	1.3	1.4	1.8	1.8	2.5	1.4	1.4	1.8
+ 04911: Insulin secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04910: Insulin signaling pathway	0	0	1.3	0	1.5	0	0	0	0	0	1.3	0	0	0
PTPRF			V
SORBS1					V						V
+ 04922: Glucagon signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04923: Regulation of lipolysis in adipocytes	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04920: Adipocytokine signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 03320: PPAR signaling pathway	0	0	0	0	1.7	0	0	0	0	0	1.6	0	0	0
SORBS1					V						V
+ 04912: GnRH signaling pathway	0	1.4	1.5	0	0	0	0	0	0	0	0	0	0	0
EGFR		V	V
+ 04913: Ovarian steroidogenesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04915: Estrogen signaling pathway	0	1.2	1.3	0	0	0	0	0	0	0	0	0	0	0
EGFR		V	V
+ 04914: Progesterone-mediated oocyte maturation	8.2	8	8.2	8.5	8.1	6.4	6.1	6.3	8	8.1	8.3	6.6	6.3	8
CCNB1	V	V	V	V	V				V	V	V			V
CDK1	V	V	V	V	V				V	V	V		V	V
MAD2L1	V	V	V	V	V				V	V	V			V
BUB1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CDC25A	V	V	V	V					V	V	V		V	V
CDC25C	V	V	V	V	V	V	V	V	V	V	V	V	V	V
PLK1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CCNB2	V	V	V		V	V	V	V	V	V	V	V		V
PKMYT1	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CCNA2	V	V	V	V	V	V	V	V	V	V	V	V		V
CDK2				V
+ 04917: Prolactin signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04921: Oxytocin signaling pathway	0	1.2	1.2	0	0	0	0	0	0	0	0	0	0	0
EGFR		V	V
+ 04926: Relaxin signaling pathway	0	1.2	1.3	0	0	0	0	0	0	0	0	0	0	0
EGFR		V	V
+ 04918: Thyroid hormone synthesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04919: Thyroid hormone signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04928: Parathyroid hormone synthesis, secretion and action	0	1.3	1.4	0	0	0	0	0	0	0	0	0	0	0
EGFR		V	V
+ 04916: Melanogenesis	0	1.4	0	0	0	0	0	0	0	0	0	0	0	0
TCF7L2		V
+ 04924: Renin secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04614: Renin-angiotensin system	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04925: Aldosterone synthesis and secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04927: Cortisol synthesis and secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 5.3 Circulatory system	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04260: Cardiac muscle contraction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04261: Adrenergic signaling in cardiomyocytes	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04270: Vascular smooth muscle contraction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 5.4 Digestive system	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04970: Salivary secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04971: Gastric acid secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04972: Pancreatic secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04976: Bile secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04973: Carbohydrate digestion and absorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04974: Protein digestion and absorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04975: Fat digestion and absorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04979: Cholesterol metabolism	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04977: Vitamin digestion and absorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04978: Mineral absorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 5.5 Excretory system	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04962: Vasopressin-regulated water reabsorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04960: Aldosterone-regulated sodium reabsorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04961: Endocrine and other factor-regulated calcium reabsorption	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04964: Proximal tubule bicarbonate reclamation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04966: Collecting duct acid secretion	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 5.6 Nervous system	0	0	0	0	0	0	0	0	0	0	0.4	0	0	0
+ 04724: Glutamatergic synapse	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04727: GABAergic synapse	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04725: Cholinergic synapse	0	0	0	0	0	0	0	0	0	0	1.4	0	0	0
FYN											V
+ 04728: Dopaminergic synapse	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04726: Serotonergic synapse	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04720: Long-term potentiation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04730: Long-term depression	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04723: Retrograde endocannabinoid signaling	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04721: Synaptic vesicle cycle	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04722: Neurotrophin signaling pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 5.7 Sensory system	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04744: Phototransduction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04740: Olfactory transduction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04742: Taste transduction	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04750: Inflammatory mediator regulation of TRP channels	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 5.8 Development and regeneration	0	0.8	0	0	0	0	0	0	0	0	1.8	0	0	0
+ 04360: Axon guidance	0	1.1	0	0	0	0	0	0	0	0	1.2	0	0	0
MET		V
FYN											V
+ 04380: Osteoclast differentiation	0	0	0	0	0	0	0	0	0	0	1.4	0	0	0
FYN											V
+ 5.9 Aging	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04211: Longevity regulating pathway	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04213: Longevity regulating pathway - multiple species	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 5.10 Environmental adaptation	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04710: Circadian rhythm	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04713: Circadian entrainment	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 04714: Thermogenesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 6. Human Diseases	7.3	16.7	12.2	5.1	1.9	8	10.6	8.6	8.3	7.9	1.4	4.6	5.2	11.4
+ 6.1 Cancer: overview	3.8	9.2	6.9	3.1	2.5	3.6	4.7	4.2	4.7	4.2	2.5	2.1	2.8	5.5
+ 05200: Pathways in cancer	1.9	4.6	3.8	1.4	0.7	2.6	3	3.2	2.4	2.5	0	1	1.7	3
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
CCNE2	V	V	V				V	V	V	V
EGFR		V	V
ERBB2		V					V							V
MET		V
TCF7L2		V
CCNE1		V	V			V		V	V	V			V	V
CTNNA1			V
CDK2				V
CTNNA3					V
CDH1														V
+ 05202: Transcriptional misregulation in cancer	0	1.1	1.1	0	0	0	0	0	1.1	0	0	0	0	0
MET		V
CDKN2C			V						V
+ 05206: MicroRNAs in cancer	4.6	6.9	5.9	3.3	1.4	4.5	5	5.2	5.1	5.2	2.3	2.8	4.4	5.8
CDC25A	V	V	V	V					V	V	V		V	V
CDC25C	V	V	V	V	V	V	V	V	V	V	V	V	V	V
CCNE2	V	V	V				V	V	V	V
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
MET		V
CCNE1		V	V			V		V	V	V			V	V
EGFR		V	V
ERBB2		V					V							V
ERBB3														V
+ 05205: Proteoglycans in cancer	0	2.7	1.1	0	1.3	1.4	1.3	0	0	0	0	0	0	2
ERBB2		V					V							V
MET		V
EGFR		V	V
ERBB4					V	V
ERBB3														V
+ 05204: Chemical carcinogenesis	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 05203: Viral carcinogenesis	4.9	4.8	4.3	4.5	4	2.5	3.2	4.2	5.4	4.9	3.7	2.6	2.4	4.2
RBL1	V								V
CCNA2	V	V	V	V	V	V	V	V	V	V	V	V		V
CCNE2	V	V	V				V	V	V	V
CDC20	V	V	V	V	V		V	V	V	V	V	V		V
CHEK1	V	V		V	V				V	V	V			V
CDK1	V	V	V	V	V				V	V	V		V	V
CCNE1		V	V			V		V	V	V			V	V
CDK2				V
+ 05230: Central carbon metabolism in cancer	0	3.6	1.6	0	0	0	1.8	0	0	0	0	0	0	1.6
EGFR		V	V
ERBB2		V					V							V
MET		V
+ 05231: Choline metabolism in cancer	0	2.4	1.4	0	0	0	0	0	0	0	1.5	0	0	0
EGFR		V	V
WASF3		V
WAS											V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	0	1.4	1.5	0	0	0	0	0	0	0	0	0	0	0
EGFR		V	V
+ 6.2 Cancer: specific types	7.6	15.2	11.4	5	0.8	8.7	10.1	9.2	8	8.1	0	5	5.4	10.4
+ 05210: Colorectal cancer	0	2.5	1.5	0	0	0	0	0	0	0	0	0	0	0
TCF7L2		V
EGFR		V	V
+ 05212: Pancreatic cancer	2.7	4.4	3.7	1.7	0	3.1	3.9	3.1	2.6	2.7	0	1.9	1.8	3.6
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
ERBB2		V					V							V
EGFR		V	V
+ 05225: Hepatocellular carcinoma	2.2	4.3	3	1.3	0	2.6	2.4	2.6	2.1	2.1	0	1.6	1.4	2.1
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
EGFR		V	V
TCF7L2		V
MET		V
+ 05226: Gastric cancer	3.1	6.3	5.3	2.4	1.4	3.6	4.2	4.4	3.8	3.9	0	1.6	2.6	4.5
CCNE2	V	V	V				V	V	V	V
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
TCF7L2		V
MET		V
ERBB2		V					V							V
CCNE1		V	V			V		V	V	V			V	V
EGFR		V	V
CTNNA1			V
CDK2				V
CTNNA3					V
CDH1														V
+ 05214: Glioma	2.7	3.6	3.7	1.7	0	3.1	2.9	3.1	2.6	2.7	0	1.9	1.8	2.6
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
EGFR		V	V
+ 05216: Thyroid cancer	0	1.8	0	0	0	0	0	0	0	0	0	0	0	1.8
TCF7L2		V
CDH1														V
+ 05221: Acute myeloid leukemia	0	1.6	0	0	0	0	0	0	0	0	0	0	0	0
TCF7L2		V
+ 05220: Chronic myeloid leukemia	2.7	2.6	2.7	1.7	0	3.1	2.9	3.1	2.6	2.7	0	1.9	1.8	2.6
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
+ 05217: Basal cell carcinoma	0	1.6	0	0	0	0	0	0	0	0	0	0	0	0
TCF7L2		V
+ 05218: Melanoma	2.7	4.4	3.7	1.7	0	3.1	3	3.1	2.7	2.7	0	2	1.8	3.6
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
EGFR		V	V
MET		V
CDH1														V
+ 05211: Renal cell carcinoma	0	1.5	0	0	0	0	0	0	0	0	0	0	0	0
MET		V
+ 05219: Bladder cancer	3.1	4.9	4.1	1.9	0	3.4	4.4	3.4	3	3.1	0	2.2	2.1	4.9
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
EGFR		V	V
ERBB2		V					V							V
CDH1														V
+ 05215: Prostate cancer	3.5	6.2	5	2.7	0	3.9	4.6	4.8	4.2	4.2	0	1.8	2.9	4.2
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
CCNE2	V	V	V				V	V	V	V
TCF7L2		V
EGFR		V	V
ERBB2		V					V							V
CCNE1		V	V			V		V	V	V			V	V
CDK2				V
+ 05213: Endometrial cancer	0	3.8	2.9	0	1.9	0	1.9	0	0	0	0	0	0	2.8
ERBB2		V					V							V
TCF7L2		V
EGFR		V	V
CTNNA1			V
CTNNA3					V
CDH1														V
+ 05224: Breast cancer	2.2	4.5	3.1	1.3	0	2.7	3.4	2.6	2.2	2.2	0	1.6	1.5	3
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
EGFR		V	V
ERBB2		V					V							V
TCF7L2		V
+ 05222: Small cell lung cancer	3.5	4.2	4.3	2.7	0	4	3.8	4.8	4.2	4.3	0	1.8	2.9	3.4
CCNE2	V	V	V				V	V	V	V
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
CCNE1		V	V			V		V	V	V			V	V
CDK2				V
+ 05223: Non-small cell lung cancer	2.8	4.5	3.8	1.7	0	3.2	4	3.1	2.7	2.8	0	2	1.9	3.7
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
EGFR		V	V
ERBB2		V					V							V
+ 6.12 Drug resistance: antineoplastic	1.3	4.6	2.9	0.8	0	1.5	3.6	1.5	1.7	1.3	0	0.9	0.8	3.8
+ 01521: EGFR tyrosine kinase inhibitor resistance	0	3.5	1.6	0	0	0	1.7	0	0	0	0	0	0	2.6
ERBB2		V					V							V
EGFR		V	V
MET		V
ERBB3														V
+ 01524: Platinum drug resistance	0	1.5	0	0	0	0	1.7	0	0	0	0	0	0	1.5
ERBB2		V					V							V
+ 01523: Antifolate resistance	0	0	0	0	0	0	0	0	0	0	0	0	0	0
+ 01522: Endocrine resistance	2.5	4.2	4.3	1.5	0	2.9	3.7	2.9	3.4	2.5	0	1.8	1.7	3.4
E2F1	V	V	V	V		V	V	V	V	V			V	V
E2F2	V	V	V			V	V	V	V	V		V		V
EGFR		V	V
ERBB2		V					V							V
CDKN2C			V						V