Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	MIC_WT	MIC_HBx(p53-)	MIC_Src(p53-)	MIC_HBx,Src(p53-)	NGS_WT	NGS_HBx(p53-)	NGS_Src(p53-)	NGS_HBx,Src(p53-)
	172/545	256/760	417/1156	561/1438	170/489	170/447	517/1247	571/1387
+ 1. Metabolism	7.4	10.5	12.2	14.6	7	10.2	14.2	14.6
+ 1.0 Global and overview maps	3.7	5.4	6.4	9	3.2	8.2	9.9	10
+ 01100: Metabolic pathways	2.7	5.1	7.5	9	2.8	5.3	8.1	9.1
arg2	V	V			V	V
tgds	V		V
elovl6	V	V		V	V	V	V	V
scd	V		V	V	V	V	V	V
aldoab	V	V		V	V	V		V
aldh2.1	V
hkdc1	V	V	V	V	V	V	V	V
pik3cg	V				V		V
mtmr2	V	V	V			V	V
mtmr7b	V
mtmr7a	V		V	V
inpp5ka	V
aspa	V				V			V
sdsl	V		V
pnp5a	V		V		V	V	V
umps	V
itpa	V		V	V			V	V
aacs	V	V	V	V
acaca	V		V
enosf1	V
b3gnt2b	V					V
mgat4b	V	V
gpib	V				V
chac1	V	V	V		V	V	V
fkrp	V
cyp26b1	V				V	V
lpin1	V		V	V
papss1	V
papss2a	V				V
fdft1	V		V	V			V	V
rgn	V
mat2aa	V	V	V		V	V
dnmt3bb.2	V
sqlea	V	V	V	V	V		V	V
lss	V		V	V
msmo1	V		V	V	V		V	V
hsd17b7	V		V	V			V	V
sc5d	V		V	V
ctps1a	V	V	V	V	V		V	V
uck2a	V		V		V
etnk2	V			V
fdps	V		V	V
pck1	V	V	V	V
pcxb	V	V	V	V
gck	V	V	V		V	V	V	V
taldo1	V			V
ext1a	V
mibp	V			V				V
gyg2	V	V
nqo1	V
ampd3b	V	V
p4ha1b	V	V	V	V
tcirg1b	V	V	V
cbr4		V		V			V	V
pdxkb		V
bckdhb		V
hsd17b12a		V	V		V	V	V
elovl2		V		V		V	V	V
dao.3		V
agxtb		V	V	V		V	V	V
gstm.1		V	V
gsta.1		V
gstt1a		V		V
gstm.2		V
anpepb		V
glula		V	V	V		V	V	V
aldh9a1a.1		V
g6pca.1		V	V
g6pca.2		V	V	V		V	V	V
inpp4ab		V		V
mtmr8		V				V
ldhba		V		V		V		V
bcat1		V		V		V		V
ugt5g1		V
upp2		V		V		V		V
impdh1b		V	V
atic		V		V
nudt9		V
esd		V				V
alg5		V	V	V				V
hmox2a		V		V
hmox1a		V	V	V			V	V
amy2a		V
cyp1a		V
cyp3a65		V		V
phykpl		V	V			V	V
cyp24a1		V	V
papss2b		V			V
hsd11b2		V	V			V	V
tdo2b		V		V		V	V	V
mthfd2		V	V			V		V
akr1a1a		V
gne		V	V	V		V		V
nansa		V	V	V
mat2al		V					V
mat2ab		V
acsl4b		V	V	V		V	V	V
nsdhl		V	V	V
si:dkey-91i10.3		V				V
me1		V
sephs1		V		V			V	V
pisd		V					V
chkb		V	V	V
ptges3a		V		V			V	V
cbr1		V
dgat1a		V
mogs		V	V	V
man2a1		V
galnt14		V					V
pigc		V	V
ugcg		V
b4galt4		V
pgam2		V		V		V
alg9		V	V	V			V	V
glud1a		V					V
mpi		V			V	V		V
pigf		V	V				V
hmbsa		V		V
qdprb1		V	V
acp5b		V			V	V		V
p4ha2		V	V	V		V		V
p4ha1a		V
cox4i2		V		V
uqcrfs1		V		V
ndufa9a		V
hadhaa			V	V				V
pomt2			V
pomt1			V
fktn			V					V
hsd17b12b			V	V			V	V
elovl5			V	V
dao.1			V
glulb			V				V	V
scly			V
pgm2			V	V			V	V
pi4kb			V	V
pip5k1ba			V
ocrl			V	V			V
pik3c3			V	V
mtm1			V
pip4k2ca			V
plcd3a			V				V
impa1			V	V			V
aoc1			V
gatm			V	V			V	V
cad			V
alas2			V
tdh			V	V
gss			V			V
nit2			V
eprs1			V	V			V	V
tk1			V	V
gmpr2			V	V			V
pkmb			V
guk1a			V	V			V	V
adsl			V				V
ca5a			V	V
acss1			V		V		V
grhpra			V
mgat1b			V	V
ppox			V	V			V
st6galnac1.1			V
b4galt1			V
gale			V			V	V
dhcr24			V	V			V	V
chia.6			V
pgm3			V				V	V
gcsha			V				V
acp1			V
pgd			V	V			V	V
pgls			V			V	V	V
pmm2			V	V			V	V
psat1			V	V			V	V
pipox			V
ckmt1			V	V			V	V
psph			V	V
acat2			V	V			V	V
mvda			V	V	V		V	V
mvk			V	V			V	V
cyp51			V	V
ebp			V	V			V	V
dhcr7			V	V
hsd3b7			V
fbp1a			V
me3			V
cmpk			V				V	V
uck2b			V
chka			V	V
pafah1b1a			V	V
cers5			V	V	V	V	V	V
smpd3			V
sptlc2b			V				V	V
cyp2p7			V	V
alox5a			V
ptges3b			V
mgll			V
cel.1			V	V
cel.2			V
idi1			V	V			V	V
alg8			V				V
ddost			V	V			V	V
man1b1b			V
zgc:172295			V
qars1			V
alg12			V				V
odc1			V		V
vkorc1l1			V
zgc:153031			V	V			V	V
dhfr			V				V
ampd1			V
adkb			V	V			V	V
zgc:86811			V	V				V
pcca			V				V
suox			V
hmgcra			V	V			V	V
aclya			V	V			V	V
cox6a1			V	V			V	V
atp6v1g1			V				V
atp6v1b2			V
atp6v1c1b			V	V	V			V
atp6v0a2b			V
ndufa4			V
hadhab				V				V
hadh				V				V
gmppab				V	V		V	V
crls1				V				V
fads2				V				V
tecrb				V
acox1				V
dao.2				V
rrm1				V			V	V
zgc:152830				V
gpx8				V
oplah				V
aldh3a2a				V				V
aldh2.2				V
pah				V				V
pgm1				V				V
g6pc3				V
pi4k2b				V				V
sacm1lb				V				V
pip4k2aa				V			V	V
plcg2				V				V
aldh4a1				V				V
alas1				V				V
dpys				V
fhit				V				V
nme4				V			V	V
cant1b				V
zgc:103759				V				V
gda				V				V
impdh2				V
paics				V				V
nudt5				V				V
mgat5				V				V
dlat				V				V
cox10				V				V
cox15				V				V
pcyt1ab				V
b4gat1				V				V
alpl				V
hykk.2				V
cbsb				V
aco2				V			V	V
allc				V
dcxr				V
ugdh				V			V	V
galk1				V			V	V
cmasa				V				V
gkup				V			V	V
aldh5a1				V
mri1				V
dnmt3aa				V				V
asrgl1				V				V
mccc2				V			V	V
ppt1				V				V
acsl5				V
bdh1				V
bdh2				V
tm7sf2				V				V
tktb				V
tyms				V				V
pla2g6				V
pla2g1b				V
cds2				V				V
agpat4				V				V
agps				V			V	V
lpcat1				V
asah1a				V	V			V
cbr1l				V
nnt				V				V
lipg				V	V	V	V	V
trit1				V
stt3a				V				V
stt3b				V
rpn1				V				V
pigq				V			V	V
b3gnt5a				V
b4galt6				V
cmbl				V
uprt				V		V	V	V
extl3				V
glceb				V
glcea				V
sgsh				V
idh1				V			V	V
aldh1a2				V			V	V
rdh12				V			V	V
dhrs3b				V
pigw				V				V
pygb				V
agla				V
c1galt1b				V				V
b3gat3				V			V	V
gch1				V				V
adss2				V				V
dguok				V
ndufs1				V				V
glb1					V	V
uros					V
adcy8					V		V
gucy2f					V
tigarb					V	V
pomk					V
srm					V
ak4					V
etnppl					V	V	V
xylt2					V		V
ppap2d					V
nmnat1					V			V
zgc:64002					V	V		V
chsy1					V
eno1a					V	V	V
bco1					V		V
gys1					V
b4galt7					V
atp6v0cb					V
scp2a						V		V
aldob						V
pde7a						V
uox						V	V
mdh1aa						V
pfkfb3						V
tat						V	V
hgd						V
fbp1b						V		V
gapdh						V
uck1						V		V
b3gnt5b						V		V
b3galt2						V
cpox						V	V	V
hao2						V	V	V
galns						V		V
galm						V
cox11						V
mcat							V
hsd17b8							V
sdhc							V
pld1a							V	V
hacd3							V
rrm2							V
gstp2							V
mtr							V	V
hk1							V
ippk							V	V
mao							V
bcat2							V	V
entpd8							V
pkma							V
ntpcr							V	V
miox							V	V
gla							V
dpm3							V
dpm1							V
pfkfb2a							V
mgat2							V
gpia							V
hexdc							V
chia.4							V
gldc							V	V
smox							V
prdx6							V
acads							V	V
ugp2a							V
xylb							V
fpgt							V
gcdha							V
aldh8a1							V
asns							V
mtap							V
rpe							V
urad							V
degs2							V
sptlc3							V	V
alox12							V
ptgesl							V
tbxas1							V
nadsyn1							V	V
dad1							V
pgp							V
hsd17b10							V
idh2							V
rdh8a							V
pigb							V
pigk							V	V
pigs							V	V
hmbsb							V
pcbd1							V	V
gapdhs							V
uqcrc1							V
cox6b1							V
cox7a2a							V
atp6v0d1							V
atp6v1ba							V
atp6v1f							V
si:ch211-235e9.6							V
ndufab1b							V	V
ndufs6							V	V
mthfr								V
gstk1								V
gsr								V
pik3cd								V
mtmr3								V
plce1								V
got1								V
nudt2								V
nme6								V
dpm2								V
blvrb								V
gclm								V
ak1								V
gfpt1								V
gmds								V
adi1								V
dnmt3ab								V
ivd								V
si:ch211-198n5.11								V
mccc1								V
ppt2								V
pla2g4aa								V
coasy								V
adpgk								V
qrsl1								V
prps1b								V
alg3								V
coq3								V
coq6								V
gart								V
ext1b								V
rdh10b								V
enoph1								V
pigx								V
gcnt4a								V
adka								V
acp2								V
cox6b2								V
cox17								V
atp6v1e1b								V
cyc1								V
ndufa7								V
ndufa5								V
+ 01200: Carbon metabolism	2.2	1.9	3.3	2.6	1.7	4.9	4.9	4
aldoab	V	V		V	V	V		V
hkdc1	V	V	V	V	V	V	V	V
gck	V	V	V		V	V	V	V
gpib	V				V
taldo1	V			V
sdsl	V		V
pcxb	V	V	V	V
rgn	V
pgam2		V		V		V
agxtb		V	V	V		V	V	V
esd		V				V
me1		V
glud1a		V					V
fbp1a			V
pgls			V			V	V	V
pgd			V	V			V	V
pkmb			V
pcca			V				V
acat2			V	V			V	V
psat1			V	V			V	V
psph			V	V
gcsha			V				V
me3			V
hadhaa			V	V				V
acss1			V		V		V
tktb				V
dlat				V				V
idh1				V			V	V
aco2				V			V	V
acox1				V
hadhab				V				V
eno1a					V	V	V
aldob						V
gapdh						V
fbp1b						V		V
mdh1aa						V
me2						V		V
hao2						V	V	V
rpe							V
hk1							V
gpia							V
pkma							V
sdhc							V
idh2							V
gldc							V	V
acads							V	V
pgp							V
adpgk								V
mthfr								V
prps1b								V
got1								V
+ 01210: 2-Oxocarboxylic acid metabolism	0	0.7	0	1.5	0	1	2.3	2.7
bcat1		V		V		V		V
aco2				V			V	V
idh1				V			V	V
idh2							V
bcat2							V	V
got1								V
+ 01212: Fatty acid metabolism	1.1	1.7	2.2	4.5	1.3	3	3.5	4.2
elovl6	V	V		V	V	V	V	V
scd	V		V	V	V	V	V	V
acaca	V		V
cbr4		V		V			V	V
hsd17b12a		V	V		V	V	V
elovl2		V		V		V	V	V
acsl4b		V	V	V		V	V	V
hsd17b12b			V	V			V	V
acat2			V	V			V	V
hadhaa			V	V				V
elovl5			V	V
tecrb				V
hadh				V				V
hadhab				V				V
fads2				V				V
acox1				V
acsl5				V
ppt1				V				V
scp2a						V		V
mcat							V
hsd17b8							V
hacd3							V
acads							V	V
ppt2								V
+ 01230: Biosynthesis of amino acids	2.2	2.8	1.5	2.6	1.4	4.2	3.3	2.4
aldoab	V	V		V	V	V		V
sdsl	V		V
pcxb	V	V	V	V
arg2	V	V			V	V
taldo1	V			V
mat2aa	V	V	V		V	V
pgam2		V		V		V
bcat1		V		V		V		V
glula		V	V	V		V	V	V
mat2al		V					V
mat2ab		V
pkmb			V
psat1			V	V			V	V
psph			V	V
glulb			V				V	V
tktb				V
aco2				V			V	V
idh1				V			V	V
pah				V				V
cbsb				V
eno1a					V	V	V
gapdh						V
aldob						V
tat						V	V
pkma							V
rpe							V
bcat2							V	V
mtr							V	V
idh2							V
asns							V
prps1b								V
got1								V
+ 1.1 Carbohydrate metabolism	5.4	5.9	7.4	8.7	4.3	7.3	9.1	8.3
+ 00010: Glycolysis / Gluconeogenesis	2.4	3.4	2.1	2.6	2.5	4.9	2.3	2.4
aldoab	V	V		V	V	V		V
aldh2.1	V
gpib	V				V
hkdc1	V	V	V	V	V	V	V	V
gck	V	V	V		V	V	V	V
pck1	V	V	V	V
aldh9a1a.1		V
akr1a1a		V
ldhba		V		V		V		V
pgam2		V		V		V
g6pca.1		V	V
g6pca.2		V	V	V		V	V	V
pkmb			V
fbp1a			V
pgm2			V	V			V	V
acss1			V		V		V
aldh3a2a				V				V
aldh2.2				V
dlat				V				V
pgm1				V				V
g6pc3				V
eno1a					V	V	V
aldob						V
gapdh						V
fbp1b						V		V
galm						V
pkma							V
gapdhs							V
gpia							V
hk1							V
adpgk								V
+ 00020: Citrate cycle (TCA cycle)	1.2	0.9	1	2.1	0	0.6	1.9	1.2
pcxb	V	V	V	V
pck1	V	V	V	V
aclya			V	V			V	V
idh1				V			V	V
aco2				V			V	V
dlat				V				V
mdh1aa						V
idh2							V
sdhc							V
+ 00030: Pentose phosphate pathway	2.6	0.4	1.7	2.3	1.4	2.8	2.1	2.9
gpib	V				V
aldoab	V	V		V	V	V		V
rgn	V
taldo1	V			V
pgm2			V	V			V	V
fbp1a			V
pgd			V	V			V	V
pgls			V			V	V	V
tktb				V
pgm1				V				V
aldob						V
fbp1b						V		V
gpia							V
rpe							V
prps1b								V
+ 00040: Pentose and glucuronate interconversions	0	1.4	0	1.4	0	0	2.7	0.8
ugt5g1		V
akr1a1a		V
dcxr				V
ugdh				V			V	V
gkup				V			V	V
rpe							V
xylb							V
ugp2a							V
+ 00051: Fructose and mannose metabolism	1.7	1.3	1.8	1.9	3	4.2	2.1	2.4
hkdc1	V	V	V	V	V	V	V	V
aldoab	V	V		V	V	V		V
enosf1	V
mpi		V			V	V		V
pfkfb4b			V	V
pfkfb4a			V	V
pmm2			V	V			V	V
fbp1a			V
gmppab				V	V		V	V
tigarb					V	V
pfkfb3						V
aldob						V
fbp1b						V		V
hk1							V
pfkfb2a							V
fpgt							V
gmds								V
+ 00052: Galactose metabolism	1.3	2.3	3.2	2.4	2.1	4.1	4.1	2.5
gck	V	V	V		V	V	V	V
hkdc1	V	V	V	V	V	V	V	V
g6pca.1		V	V
g6pca.2		V	V	V		V	V	V
pgm2			V	V			V	V
b4galt1			V
gale			V			V	V
pgm1				V				V
g6pc3				V
galk1				V			V	V
glb1					V	V
galm						V
gla							V
hk1							V
ugp2a							V
+ 00053: Ascorbate and aldarate metabolism	1.7	1.5	0	2.1	0	0	1.7	2.2
rgn	V
aldh2.1	V
ugt5g1		V
aldh9a1a.1		V
gkup				V			V	V
ugdh				V			V	V
aldh3a2a				V				V
aldh2.2				V
miox							V	V
+ 00500: Starch and sucrose metabolism	2.6	3.3	2.2	2.8	2.7	2.2	3.1	1.9
hkdc1	V	V	V	V	V	V	V	V
gyg2	V	V
gck	V	V	V		V	V	V	V
gpib	V				V
g6pca.1		V	V
g6pca.2		V	V	V		V	V	V
amy2a		V
pgm2			V	V			V	V
pgm1				V				V
g6pc3				V
pygb				V
agla				V
gys1					V
hk1							V
ugp2a							V
gpia							V
+ 00520: Amino sugar and nucleotide sugar metabolism	1.3	2.4	3.3	3.9	2.6	2.7	5	5.1
hkdc1	V	V	V	V	V	V	V	V
gpib	V				V
gck	V	V	V		V	V	V	V
gne		V	V	V		V		V
nansa		V	V	V
cyb5r2		V	V	V
mpi		V			V	V		V
pgm3			V				V	V
chia.6			V
gale			V			V	V
pmm2			V	V			V	V
pgm2			V	V			V	V
cmasa				V				V
cmah				V				V
gkup				V			V	V
ugdh				V			V	V
pgm1				V				V
galk1				V			V	V
gmppab				V	V		V	V
chia.4							V
hk1							V
fpgt							V
gpia							V
ugp2a							V
gfpt1								V
gmds								V
+ 00620: Pyruvate metabolism	2.1	2.2	2.9	2.1	0.4	1.8	0.6	1.3
pck1	V	V	V	V
pcxb	V	V	V	V
aldh2.1	V
acaca	V		V
me1		V
ldhba		V		V		V		V
aldh9a1a.1		V
pkmb			V
me3			V
acss1			V		V		V
acat2			V	V			V	V
grhpra			V
aldh3a2a				V				V
aldh2.2				V
dlat				V				V
me2						V		V
mdh1aa						V
pkma							V
+ 00630: Glyoxylate and dicarboxylate metabolism	0	0.8	3.4	1.1	0.5	2.7	4.5	2.6
agxtb		V	V	V		V	V	V
glula		V	V	V		V	V	V
grhpra			V
acat2			V	V			V	V
pcca			V				V
gcsha			V				V
glulb			V				V	V
acss1			V		V		V
aco2				V			V	V
hao2						V	V	V
mdh1aa						V
pgp							V
gldc							V	V
+ 00640: Propanoate metabolism	0.5	1	2.1	1.8	0.6	0.7	1.5	1.9
acaca	V		V
ldhba		V		V		V		V
bckdhb		V
pcca			V				V
acss1			V		V		V
hadhaa			V	V				V
acat2			V	V			V	V
hadhab				V				V
acox1				V
acads							V	V
+ 00650: Butanoate metabolism	0.7	0.5	1.5	3.8	0	0	0.8	2.3
aacs	V	V	V	V
acat2			V	V			V	V
hadhaa			V	V				V
bdh1				V
bdh2				V
hadh				V				V
hadhab				V				V
aldh5a1				V
acads							V	V
+ 00562: Inositol phosphate metabolism	1.9	0.6	2.6	2	0.2	0.7	1.7	1.8
inpp5ka	V
mtmr2	V	V	V			V	V
mtmr7b	V
mtmr7a	V		V	V
pik3cg	V				V		V
inpp4ab		V		V
mtmr8		V				V
pip4k2ca			V
ocrl			V	V			V
mtm1			V
impa1			V	V			V
pi4kb			V	V
pip5k1ba			V
pik3c3			V	V
plcd3a			V				V
pip4k2aa				V			V	V
pi4k2b				V				V
plcg2				V				V
sacm1lb				V				V
miox							V	V
ippk							V	V
mtmr3								V
plce1								V
pik3cd								V
+ 1.2 Energy metabolism	1.3	1.6	1.7	1.1	1.4	0.6	2	1.4
+ 00190: Oxidative phosphorylation	0	0.3	0.4	0.3	0.2	0.1	1.7	1.4
tcirg1b	V	V	V
cox4i2		V		V
ndufa9a		V
uqcrfs1		V		V
ndufa4			V
cox6a1			V	V			V	V
atp6v1g1			V				V
atp6v1b2			V
atp6v1c1b			V	V	V			V
atp6v0a2b			V
ndufs1				V				V
cox15				V				V
ppa1b				V			V
cox10				V				V
atp6v0cb					V
cox11						V
si:ch211-235e9.6							V
ndufab1b							V	V
ndufs6							V	V
cox7a2a							V
uqcrc1							V
cox6b1							V
atp6v0d1							V
atp6v1ba							V
atp6v1f							V
sdhc							V
ndufa7								V
ndufa5								V
cox17								V
cyc1								V
cox6b2								V
atp6v1e1b								V
+ 00910: Nitrogen metabolism	0	1.5	1.8	0.9	0	1	1.7	1
glula		V	V	V		V	V	V
glud1a		V					V
ca5a			V	V
glulb			V				V	V
+ 00920: Sulfur metabolism	2.1	1	0.7	0.6	2.2	0	0	0
papss1	V
papss2a	V				V
papss2b		V			V
suox			V
selenbp1				V
+ 1.3 Lipid metabolism	2.8	3.9	5.7	9.4	2.8	4.1	4.8	5.2
+ 00061: Fatty acid biosynthesis	0.9	1.5	1.1	1.6	0	1	2.4	1
acaca	V		V
acsl4b		V	V	V		V	V	V
cbr4		V		V			V	V
acsl5				V
mcat							V
hsd17b8							V
+ 00062: Fatty acid elongation	0.5	1.5	1.5	3.9	1.3	2.1	1.9	3.1
elovl6	V	V		V	V	V	V	V
hsd17b12a		V	V		V	V	V
elovl2		V		V		V	V	V
hadhaa			V	V				V
hsd17b12b			V	V			V	V
elovl5			V	V
ppt1				V				V
hadhab				V				V
hadh				V				V
tecrb				V
them4				V
hacd3							V
ppt2								V
+ 00071: Fatty acid degradation	0.4	0.7	0.8	3.1	0	0.5	1.1	2.3
aldh2.1	V
acsl4b		V	V	V		V	V	V
aldh9a1a.1		V
hadhaa			V	V				V
acat2			V	V			V	V
hadh				V				V
hadhab				V				V
acsl5				V
acox1				V
aldh3a2a				V				V
aldh2.2				V
acads							V	V
gcdha							V
+ 00072: Synthesis and degradation of ketone bodies	0	0	0.9	2.4	0	0	0.8	0.7
acat2			V	V			V	V
bdh1				V
bdh2				V
+ 00100: Steroid biosynthesis	4.4	2.1	8.5	7.1	1.7	0	3.8	4.2
sc5d	V		V	V
lss	V		V	V
msmo1	V		V	V	V		V	V
hsd17b7	V		V	V			V	V
fdft1	V		V	V			V	V
sqlea	V	V	V	V	V		V	V
nsdhl		V	V	V
cyp24a1		V	V
ebp			V	V			V	V
dhcr7			V	V
dhcr24			V	V			V	V
cyp51			V	V
cel.1			V	V
lipf			V	V			V	V
cel.2			V
soat1			V
tm7sf2				V				V
+ 00120: Primary bile acid biosynthesis	0.7	1.3	2.1	0.2	0.8	3.2	0	0.7
cyp46a1.2	V		V
si:dkey-91i10.3		V				V
cyp39a1		V	V	V	V	V		V
cyp46a1.3			V
hsd3b7			V
cyp46a1.1						V
scp2a						V		V
+ 00140: Steroid hormone biosynthesis	0.5	3.1	2	0.7	0.6	1.3	2.3	0.4
hsd17b7	V		V	V			V	V
hsd17b12a		V	V		V	V	V
sult2st3		V	V				V
cyp1a		V
cyp3a65		V		V
hsd11b2		V	V			V	V
ugt5g1		V
hsd17b12b			V	V			V	V
hsd17b8							V
+ 00561: Glycerolipid metabolism	0.8	1	1.3	1.7	0.9	1	0.2	0.6
lpin1	V		V	V
aldh2.1	V
dgat1a		V
aldh9a1a.1		V
akr1a1a		V
cel.1			V	V
cel.2			V
mgll			V
zgc:172295			V
lipg				V	V	V	V	V
plpp5				V
agpat4				V				V
aldh3a2a				V				V
aldh2.2				V
ppap2d					V
lpl						V		V
gla							V
+ 00564: Glycerophospholipid metabolism	0.9	0.5	0.4	3.4	0.5	1.6	0.3	0.7
etnk2	V			V
lpin1	V		V	V
mboat7	V
chkb		V	V	V
pisd		V					V
phykpl		V	V			V	V
chka			V	V
lpcat1				V
pcyt1ab				V
ache				V				V
pla2g6				V
pla2g1b				V
plpp5				V
agpat4				V				V
gpcpd1				V
cds2				V				V
crls1				V				V
lpgat1				V
ppap2d					V
etnppl					V	V	V
gpd2						V
taz						V
pld1a							V	V
pla2g4aa								V
+ 00565: Ether lipid metabolism	0	0.3	0.1	2.4	0.5	0.6	0.8	1.1
tmem86b		V
pafah1b1a			V	V
agps				V			V	V
pla2g6				V
pla2g1b				V
lpcat1				V
gdpd1				V			V	V
enpp6				V
ppap2d					V
gdpd3a						V
pld1a							V	V
pla2g4aa								V
+ 00600: Sphingolipid metabolism	0.3	0.1	0.5	0.3	2.5	0.9	1.1	0.9
arsa	V				V
ugcg		V
cers5			V	V	V	V	V	V
smpd3			V
sptlc2b			V				V	V
asah1a				V	V			V
b4galt6				V
ppap2d					V
glb1					V	V
degs2							V
sptlc3							V	V
gla							V
neu3.4								V
+ 00590: Arachidonic acid metabolism	0	0.7	0.7	1.7	0	0	1	0.2
ptges3a		V		V			V	V
cbr1		V
cyp2p7			V	V
alox5a			V
ptges3b			V
gpx8				V
pla2g6				V
pla2g1b				V
cbr1l				V
alox12							V
ptgesl							V
tbxas1							V
pla2g4aa								V
+ 00591: Linoleic acid metabolism	0	0.8	0.5	2.4	0	0	0	0.4
cyp3a65		V		V
cyp2p7			V	V
pla2g6				V
pla2g1b				V
pla2g4aa								V
+ 00592: alpha-Linolenic acid metabolism	0	0	0	2.3	0	0	0	1
acox1				V
pla2g6				V
pla2g1b				V
fads2				V				V
pla2g4aa								V
+ 01040: Biosynthesis of unsaturated fatty acids	1.3	1.7	1.8	3.4	2.2	3.6	2.7	2.5
elovl6	V	V		V	V	V	V	V
scd	V		V	V	V	V	V	V
elovl2		V		V		V	V	V
hsd17b12a		V	V		V	V	V
hsd17b12b			V	V			V	V
elovl5			V	V
fads2				V				V
tecrb				V
acox1				V
scp2a						V		V
hacd3							V
+ 1.4 Nucleotide metabolism	2.1	0.8	2.5	4	2.5	1.9	3.5	4.6
+ 00230: Purine metabolism	1.1	0.6	1.5	3.3	2.1	0.6	2.7	3.7
ampd3b	V	V
pnp5a	V		V		V	V	V
papss1	V
papss2a	V				V
itpa	V		V	V			V	V
atic		V		V
impdh1b		V	V
papss2b		V			V
nudt9		V
adsl			V				V
zgc:86811			V	V				V
ampd1			V
adkb			V	V			V	V
gmpr2			V	V			V
guk1a			V	V			V	V
pgm2			V	V			V	V
pkmb			V
rrm1				V			V	V
paics				V				V
nme4				V			V	V
adss2				V				V
impdh2				V
cant1b				V
gda				V				V
allc				V
dguok				V
nudt5				V				V
fhit				V				V
pgm1				V				V
zgc:103759				V				V
adcy8					V		V
ak4					V
gucy2f					V
ak3					V
uox						V	V
pde7a						V
rrm2							V
entpd8							V
pkma							V
ntpcr							V	V
urad							V
prps1b								V
gart								V
nme6								V
ak1								V
adka								V
nudt2								V
+ 00240: Pyrimidine metabolism	1.8	0.5	2	2.4	1.4	2.1	2.3	2.8
umps	V
ctps1a	V	V	V	V	V		V	V
uck2a	V		V		V
pnp5a	V		V		V	V	V
upp2		V		V		V		V
cad			V
cmpk			V				V	V
uck2b			V
tk1			V	V
rrm1				V			V	V
nme4				V			V	V
cant1b				V
uprt				V		V	V	V
dpys				V
tyms				V				V
uck1						V		V
rrm2							V
entpd8							V
nme6								V
nudt2								V
+ 1.5 Amino acid metabolism	2.7	3.8	4.1	5.2	1.3	4.5	4.6	6.5
+ 00250: Alanine, aspartate and glutamate metabolism	0.4	1.3	2.2	1.8	0.5	1.2	2.1	3.1
aspa	V				V			V
agxtb		V	V	V		V	V	V
glud1a		V					V
glula		V	V	V		V	V	V
nit2			V
adsl			V				V
cad			V
glulb			V				V	V
asrgl1				V				V
adss2				V				V
aldh5a1				V
aldh4a1				V				V
asns							V
got1								V
gfpt1								V
+ 00260: Glycine, serine and threonine metabolism	0.4	1.2	4.2	3	0	1.1	2	1.3
sdsl	V		V
agxtb		V	V	V		V	V	V
dao.3		V
pgam2		V		V		V
gatm			V	V			V	V
psat1			V	V			V	V
pipox			V
psph			V	V
dao.1			V
tdh			V	V
alas2			V
grhpra			V
gcsha			V				V
cbsb				V
dao.2				V
alas1				V				V
gldc							V	V
mao							V
+ 00270: Cysteine and methionine metabolism	1.3	1.9	0.9	1.3	0.9	3.2	1.6	3.3
mat2aa	V	V	V		V	V
dnmt3bb.2	V
sdsl	V		V
mat2al		V					V
mat2ab		V
ldhba		V		V		V		V
bcat1		V		V		V		V
gss			V			V
psat1			V	V			V	V
mri1				V
cbsb				V
dnmt3aa				V				V
srm					V
tat						V	V
mdh1aa						V
mtap							V
mtr							V	V
bcat2							V	V
adi1								V
dnmt3ab								V
enoph1								V
got1								V
gclm								V
+ 00280: Valine, leucine and isoleucine degradation	0.8	1.5	0.9	2.5	0	0.4	1.6	3.7
aldh2.1	V
aacs	V	V	V	V
bckdhb		V
bcat1		V		V		V		V
aldh9a1a.1		V
acat2			V	V			V	V
hadhaa			V	V				V
pcca			V				V
mccc2				V			V	V
hadhab				V				V
hadh				V				V
aldh3a2a				V				V
aldh2.2				V
bcat2							V	V
hsd17b10							V
acads							V	V
si:ch211-198n5.11								V
mccc1								V
ivd								V
+ 00290: Valine, leucine and isoleucine biosynthesis	1.7	1.6	1.4	1.3	0	1.8	1.3	2.4
sdsl	V		V
bcat1		V		V		V		V
bcat2							V	V
+ 00310: Lysine degradation	1.2	0.4	1.4	2.8	0.3	1.4	1.3	1.5
bbox1	V		V	V
plod3	V			V	V			V
aldh2.1	V
aldh9a1a.1		V
colgalt1b		V		V
hadhaa			V	V				V
acat2			V	V			V	V
pipox			V
setd3			V				V
setd7			V	V
hadhab				V				V
hadh				V				V
aldh3a2a				V				V
aldh2.2				V
hykk.2				V
setmar						V
ezh2						V
plod1a						V	V
gcdha							V
kmt2a							V
ehmt2							V	V
+ 00220: Arginine biosynthesis	0.7	2	0.9	0.2	0.8	1.7	1.4	1.3
arg2	V	V			V	V
glula		V	V	V		V	V	V
glud1a		V					V
glulb			V				V	V
got1								V
+ 00330: Arginine and proline metabolism	1.3	2.3	2	1.9	1.4	0.9	0.7	1.2
arg2	V	V			V	V
aldh2.1	V
p4ha1b	V	V	V	V
aldh9a1a.1		V
dao.3		V
p4ha2		V	V	V		V		V
p4ha1a		V
gatm			V	V			V	V
aoc1			V
ckmt1			V	V			V	V
dao.1			V
odc1			V		V
aldh3a2a				V				V
aldh2.2				V
aldh4a1				V				V
dao.2				V
srm					V
mao							V
smox							V
got1								V
+ 00340: Histidine metabolism	1.6	0.6	0.3	0.7	0.8	0	0.3	0.7
aldh2.1	V
aspa	V				V			V
aldh9a1a.1		V
aoc1			V
aldh3a2a				V				V
aldh2.2				V
mao							V
+ 00350: Tyrosine metabolism	0	0	0	0	0	1.6	0.7	0.2
hgd						V
tat						V	V
mao							V
got1								V
+ 00360: Phenylalanine metabolism	0	0	0	0.5	0	1.1	1.3	1.2
pah				V				V
tat						V	V
mao							V
got1								V
+ 00380: Tryptophan metabolism	0.4	1.1	0.7	2	0	0.5	1.4	1.7
aldh2.1	V
cyp1a		V
tdo2b		V		V		V	V	V
aldh9a1a.1		V
acat2			V	V			V	V
hadhaa			V	V				V
aoc1			V
hadh				V				V
hadhab				V				V
aldh3a2a				V				V
aldh2.2				V
mao							V
gcdha							V
aldh8a1							V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	0	0	0.9	0	1.5	1	1.8
pah				V				V
tat						V	V
got1								V
+ 1.6 Metabolism of other amino acids	1.1	2.8	1.3	2.4	1.6	0.4	1.9	1.5
+ 00410: beta-Alanine metabolism	0.5	0.3	0.2	2.1	0.6	0	0.5	1.2
aldh2.1	V
aldh9a1a.1		V
hadhaa			V	V				V
hadhab				V				V
aldh3a2a				V				V
aldh2.2				V
dpys				V
acox1				V
srm					V
acads							V	V
smox							V
+ 00430: Taurine and hypotaurine metabolism	0	0	0	0	0	0	0	0
+ 00440: Phosphonate and phosphinate metabolism	0	0	0	0.8	0	0	0	0
pcyt1ab				V
+ 00450: Selenocompound metabolism	2	1.7	0.6	0.5	2.1	0	1.3	1.2
papss1	V
papss2a	V				V
sephs1		V		V			V	V
papss2b		V			V
scly			V
mtr							V	V
+ 00471: D-Glutamine and D-glutamate metabolism	0	1.4	0	0	0	0	1.2	0
glud1a		V					V
+ 00472: D-Arginine and D-ornithine metabolism	0	1.6	1.4	1.3	0	0	0	0
dao.3		V
dao.1			V
dao.2				V
+ 00480: Glutathione metabolism	0.3	2.4	1.3	1.7	1.5	1	2	1.4
chac1	V	V	V		V	V	V
anpepb		V
gstm.1		V	V
gsta.1		V
gstt1a		V		V
gstm.2		V
gss			V			V
pgd			V	V			V	V
odc1			V		V
gpx8				V
idh1				V			V	V
oplah				V
rrm1				V			V	V
zgc:152830				V
srm					V
idh2							V
gstp2							V
rrm2							V
gclm								V
gstk1								V
gsr								V
+ 1.7 Glycan biosynthesis and metabolism	1.4	1.8	2.8	2	2.3	2.3	2.4	2.7
+ 00510: N-Glycan biosynthesis	0.3	2.1	3.6	2.7	0	0	3	2.4
mgat4b	V	V
alg9		V	V	V			V	V
man2a1		V
mogs		V	V	V
alg5		V	V	V				V
alg12			V				V
dolpp1			V				V
b4galt1			V
man1b1b			V
alg8			V				V
mgat1b			V	V
ddost			V	V			V	V
mgat5				V				V
stt3a				V				V
stt3b				V
rpn1				V				V
dpm3							V
mgat2							V
dpm1							V
dad1							V
dpm2								V
alg3								V
+ 00512: Mucin type O-glycan biosynthesis	0	0.5	0.3	0.2	0	0	0.2	0.6
galnt14		V					V
st6galnac1.1			V
c1galt1b				V				V
gcnt4a								V
+ 00515: Mannose type O-glycan biosynthesis	0.7	0	2.1	0.2	0.8	0	0	0.7
fkrp	V
b4galt1			V
pomt2			V
pomt1			V
fktn			V					V
b4gat1				V				V
pomk					V
+ 00514: Other types of O-glycan biosynthesis	0.6	0.5	1.9	1.1	0.7	0.8	0	0.6
plod3	V			V	V			V
colgalt1b		V		V
mfng			V
b4galt1			V
pomt2			V
pomt1			V
lfng				V				V
b3glcta						V
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	0	0	0.3	2.5	0	0.9	0.3
b3gat3				V			V	V
xylt2					V		V
b4galt7					V
chsy1					V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.6	0	0	1.5	1.4	0	0.6	0.5
ext1a	V
extl3				V
glceb				V
glcea				V
b3gat3				V			V	V
xylt2					V		V
b4galt7					V
ext1b								V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	1	0.9	0.6	0	0	1.2	0	0
b3gnt2b	V					V
b4galt4		V
b4galt1			V
+ 00531: Glycosaminoglycan degradation	0	0	0	0.3	0.9	1.8	0	0.3
sgsh				V
glb1					V	V
galns						V		V
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	1.4	1	0.8	0	0	2.7	3.1
pigc		V	V
pigf		V	V				V
pigq				V			V	V
pigw				V				V
pigs							V	V
pigk							V	V
pigb							V
dpm2								V
pigx								V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0.8	0.6	0.4	0.3	0	2.6	0	0.3
b3gnt2b	V					V
b4galt4		V
b4galt1			V
b3gnt5a				V
b3gnt5b						V		V
b3galt2						V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0	0	0	0	0.8	0
gla							V
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0	0	0	0	1.1	1.2	0	0
glb1					V	V
+ 00511: Other glycan degradation	0.7	0.5	0.3	0	0.8	0.8	0.3	0.7
fuca2	V
aga		V
zgc:153169			V
glb1					V	V
hexdc							V
neu3.4								V
engase								V
+ 1.8 Metabolism of cofactors and vitamins	0.8	3	2.5	3.1	1.8	2.4	2.8	5.5
+ 00730: Thiamine metabolism	0	0	0.5	0.4	1	0	0.5	1
acp1			V
alpl				V
ak4					V
ntpcr							V	V
ak1								V
+ 00740: Riboflavin metabolism	0	1.2	0.9	0	1.4	1.4	0	2.5
acp5b		V			V	V		V
acp1			V
blvrb								V
acp2								V
+ 00750: Vitamin B6 metabolism	0	1.2	0.9	0.8	0	0	0.9	0.8
pdxkb		V
psat1			V	V			V	V
+ 00760: Nicotinate and nicotinamide metabolism	1.3	0	0.2	0.5	2.1	1.5	0.6	2
mibp	V			V				V
pnp5a	V		V		V	V	V
nnt				V				V
nmnat1					V			V
zgc:64002					V	V		V
nadsyn1							V	V
+ 00770: Pantothenate and CoA biosynthesis	0	0.9	0	1.3	0	1.2	0.6	2
bcat1		V		V		V		V
dpys				V
bcat2							V	V
coasy								V
+ 00780: Biotin metabolism	0	0	0	0	0	0	0	0
+ 00785: Lipoic acid metabolism	0	0	0	0	0	0	0	0
+ 00790: Folate biosynthesis	0	1	1.2	1.9	0	0	1.1	1.5
qdprb1		V	V
cbr1		V
zgc:153031			V	V			V	V
dhfr			V				V
gch1				V				V
alpl				V
pah				V				V
cbr1l				V
pcbd1							V	V
+ 00670: One carbon pool by folate	0	2.3	1.8	1.6	0	1.9	1.7	4
mthfd2		V	V			V		V
aldh1l1		V				V
atic		V		V
zgc:153031			V	V			V	V
dhfr			V				V
tyms				V				V
mtr							V	V
gart								V
mthfr								V
mtfmt								V
+ 00830: Retinol metabolism	0.4	1.9	0.8	1	1.1	0.5	1.6	1
cyp26b1	V				V	V
dgat1a		V
cyp3a65		V		V
cyp1a		V
ugt5g1		V
lrata			V				V	V
rdh5			V
zgc:154169			V
aldh1a2				V			V	V
rdh12				V			V	V
dhrs3b				V
bco1					V		V
rdh8a							V
rdh10b								V
+ 00860: Porphyrin and chlorophyll metabolism	0	2.2	1.7	3.3	0.6	0.7	2.1	2.9
ugt5g1		V
hmbsa		V		V
hmox2a		V		V
hmox1a		V	V	V			V	V
ppox			V	V			V
alas2			V
eprs1			V	V			V	V
cox10				V				V
alas1				V				V
cox15				V				V
uros					V
cpox						V	V	V
hmbsb							V
blvrb								V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	1.1	0	0.7	0	0	1.2	0.7	1.4
nqo1	V
vkorc1l1			V
tat						V	V
coq3								V
coq6								V
+ 1.9 Metabolism of terpenoids and polyketides	1.6	0.6	4.9	3.5	0.8	0	3.7	2.5
+ 00900: Terpenoid backbone biosynthesis	1.6	0.6	4.9	3.5	0.8	0	3.7	2.5
fdps	V		V	V
pdss1	V
zmpste24		V	V	V
mvk			V	V			V	V
acat2			V	V			V	V
hmgcra			V	V			V	V
idi1			V	V			V	V
mvda			V	V	V		V	V
nus1			V
fntb			V				V
pdss2							V
+ 1.10 Biosynthesis of other secondary metabolites	2	1.8	1.6	0.8	2	3.2	3.1	1.5
+ 00232: Caffeine metabolism	0	0	0	0	0	1.6	1.1	0
uox						V	V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	2.8	2.6	2.3	1.1	2.9	2.9	3.3	2.2
hkdc1	V	V	V	V	V	V	V	V
gck	V	V	V		V	V	V	V
hk1							V
+ 1.11 Xenobiotics biodegradation and metabolism	0.7	5.1	1.3	1.5	0.2	0.5	1.3	1
+ 00980: Metabolism of xenobiotics by cytochrome P450	0	3.5	0.1	0.3	0	0	0.4	0.1
gstm.1		V	V
gsta.1		V
gstt1a		V		V
gstm.2		V
ugt5g1		V
cyp1a		V
cbr1		V
cbr1l				V
gstp2							V
akr7a3							V
gstk1								V
+ 00982: Drug metabolism - cytochrome P450	0	2.7	0.2	0.1	0	0	0.5	0.1
gstm.1		V	V
gsta.1		V
gstt1a		V		V
gstm.2		V
ugt5g1		V
gstp2							V
mao							V
gstk1								V
+ 00983: Drug metabolism - other enzymes	1.2	2.6	1.9	2.2	0.3	0.8	1.3	1.5
itpa	V		V	V			V	V
umps	V
uck2a	V		V		V
upp2		V		V		V		V
impdh1b		V	V
ugt5g1		V
gstm.1		V	V
gsta.1		V
gstt1a		V		V
gstm.2		V
uck2b			V
tk1			V	V
cmpk			V				V	V
tpmt.1				V
dpys				V
impdh2				V
nme4				V			V	V
rrm1				V			V	V
uck1						V		V
rrm2							V
gstp2							V
nme6								V
+ 2. Genetic Information Processing	1.9	2.7	6.1	9.6	3.6	3.3	15.3	10.8
+ 2.1 Transcription	0.4	1.2	1.2	2.6	0.7	0.8	7.5	4.3
+ 03020: RNA polymerase	0.6	0.4	0.7	2.5	0	0.7	1.2	4.9
polr3h	V		V					V
polr1e		V		V				V
polr1b			V				V	V
polr2k				V				V
polr3c				V		V
polr1c				V
znrd1				V				V
twistnb				V			V	V
polr2c							V
polr2eb								V
polr2gl								V
polr2h								V
polr2l								V
polr3k								V
+ 03022: Basal transcription factors	0	0.8	0.1	1.5	1.2	0.5	4.3	1.1
taf2		V
gtf2h3		V
gtf2h4			V				V
taf5l				V		V	V
taf5				V
taf10				V			V
gtf2e2				V				V
gtf2h1				V			V
taf13					V		V
cdk7					V
tbpl1							V
taf6l							V	V
taf7							V
ercc2							V
gtf2h2							V
gtf2h5							V
taf1								V
taf3								V
+ 03040: Spliceosome	0	0.9	1.2	0.5	0	0.1	7.4	1.5
zgc:55733	V
srsf10b		V	V
srsf6b		V		V
hsc70		V	V	V			V	V
snu13a		V
thoc3		V
prpf18		V
snrpd1			V
snrpg			V				V
sf3b5			V				V
cwc15			V				V
crnkl1			V
lsm8			V				V
lsm7			V				V
sart1			V				V
ddx46				V
sf3b6				V			V	V
srsf5a				V
smx5				V
prpf4				V
snu13b				V
prpf38a				V
hsp70l					V
ppih						V	V
prpf40a							V
snrpd3l							V	V
snrpe							V
snrpb							V	V
snrpd2							V
snrpa1							V
snrpb2							V
phf5a							V	V
ncbp2							V
ctnnbl1							V
pqbp1							V
lsm4							V
lsm6							V
lsm5							V
prpf31							V
prpf3							V
ddx23							V
txnl4a							V
snrnp27							V
usp39							V
acin1b							V
rbm8a							V	V
magoh							V	V
thoc2							V
zmat2							V	V
bud31							V	V
srsf1b								V
hspa1b								V
ppie								V
eftud2								V
+ 2.2 Translation	1.8	1.5	3.8	6.2	1.5	1.8	5.5	7.1
+ 03010: Ribosome	0	0	0	0.3	0	0.2	1.2	3.7
mrpl9	V
mrpl34			V				V
mrpl35			V	V
mrpl2				V
mrpl23				V				V
mrpl30				V
rsl24d1				V	V			V
mrpl20				V
mrpl32				V				V
mrps7				V			V
mrpl15						V
mrpl28						V
mrpl10							V
mrpl24							V
mrpl27							V
mrps10							V
mrps15							V	V
mrps16							V
mrps18c							V
mrps21							V
mrps2							V
rps14								V
rps15								V
rps17								V
rps24								V
rps27.1								V
rps7								V
rps21								V
rpl23								V
rpl5a								V
rpl7								V
rpl30								V
rpl39								V
uba52								V
rpl32								V
rpl35a								V
rpl27								V
rpl36								V
rpl38								V
+ 00970: Aminoacyl-tRNA biosynthesis	0.5	0.3	2.9	2.5	0.5	0.6	3.2	2.6
yars2	V					V	V
iars2		V		V				V
hars			V				V
farsa			V	V			V	V
qars1			V
vars1			V	V
tars1			V				V
yars1			V	V
eprs1			V	V			V	V
nars2				V				V
wars2				V
rars2					V		V
rars1							V
lars2							V	V
mtfmt								V
qrsl1								V
+ 03013: RNA transport	1.2	1	2	3.6	0.7	1.2	4.8	2.9
sumo3b	V
prmt5	V				V	V	V
rpp25l	V		V	V
eif4a2	V		V		V		V
eif4e2	V
nup35	V
phax		V	V				V
gemin2		V		V				V
nxt2		V		V		V		V
sumo2b		V
eif3ja		V
thoc3		V
eif4ebp3		V	V	V		V	V	V
xpot			V
gemin4			V
gemin7			V	V
sap18			V				V
sec13			V				V
rangap1a			V
eef1a2			V
rpp40			V	V
eif4ea			V	V
eif4ebp3l			V	V			V	V
clns1a				V			V
sumo1				V				V
nmd3				V				V
eif3jb				V
trnt1				V
rpp38				V
rpp21				V
pop5				V				V
rpp14				V
pop4				V				V
thoc6				V
eif2s2				V			V	V
eif4e1c				V	V			V
eif4ebp1				V				V
cyfip1				V
eif4ba					V	V		V
nup85						V
ncbp2							V
gemin8							V
rbm8a							V	V
magoh							V	V
acin1b							V
rnps1							V
pnn							V
nup107							V
seh1l							V
rae1							V
nup133							V
eif1axb							V
eif1b							V
thoc2							V
eif4e2rs1							V
upf3b							V
eif2b3							V	V
snupn								V
nup37								V
eif2s1b								V
eif4a1b								V
eif2b4								V
+ 03015: mRNA surveillance pathway	0.9	0.1	0.2	0.1	0	0.2	2.2	0.9
ppp2r5ea	V
ppp2r3c	V
ppp2r2bb	V
nxt2		V		V		V		V
sap18			V				V
pelo			V				V
dazap1			V
cstf3				V
ppp2r2d				V
rbm8a							V	V
magoh							V	V
acin1b							V
rnps1							V
pnn							V
upf3b							V
ncbp2							V
msi2a							V
smg7								V
cpsf2								V
cstf2								V
ppp2r5d								V
+ 03008: Ribosome biogenesis in eukaryotes	1.5	1.9	3.4	7.4	2.2	1.8	1.1	5.8
rpp25l	V		V	V
gnl2	V
imp4	V		V	V
wdr75	V		V	V
snu13a		V
nxt2		V		V		V		V
heatr1		V	V	V				V
lsg1		V						V
riok2		V		V				V
rbm28		V	V	V
dkc1			V	V	V		V	V
nat10			V		V	V	V
rpp40			V	V
gnl3l			V	V				V
nvl			V	V				V
nol6			V	V
zgc:86811			V	V				V
nmd3				V				V
snu13b				V
nop58				V				V
nhp2				V	V	V		V
rcl1				V
rpp38				V
pop5				V				V
pop4				V				V
gnl3				V
smfn				V			V	V
mphosph10				V				V
utp6				V
riok1				V				V
emg1				V	V	V		V
rrp7a					V			V
gtpbp4							V
tbl3							V
pwp2h							V
fbl								V
nop10								V
sbds								V
+ 2.3 Folding, sorting and degradation	0.5	2	6.2	6.6	2.5	3.4	10.1	5.4
+ 03060: Protein export	0	1.3	2.7	2.4	1.6	2.5	3.1	1.3
spcs3		V					V
hspa5		V		V	V	V		V
srp14			V				V
srp19			V				V
spcs2			V				V
sec61a1l			V	V
sec11a			V				V
srp54				V
srp9				V				V
sec63				V
srp68					V	V
sec61g						V		V
spcs1							V
+ 04141: Protein processing in endoplasmic reticulum	0.1	2.4	4.7	7.7	0.8	2	4.4	6.4
sec24c	V			V				V
hspbp1	V			V				V
mapk8a		V
canx		V	V	V			V	V
edem2		V						V
ero1b		V
mogs		V	V	V
hspa5		V		V	V	V		V
yod1		V				V
hsc70		V	V	V			V	V
pdia6		V		V				V
txndc5		V	V	V
pdia4		V	V	V			V	V
ubxn6		V
ssr3		V	V	V
calr3a			V
calr3b			V	V				V
sec61a1l			V	V
vcp			V	V			V	V
ddost			V	V			V	V
sec23b			V				V	V
nploc4			V
man1b1b			V
derl2			V
ube2d4			V
dnajb11			V
dnajc10			V				V
hsp90aa1.2			V				V	V
sec13			V				V
hsp90b1			V	V			V	V
bcl2a			V
tram1			V				V
hyou1			V	V			V	V
rrbp1a			V	V
rrbp1b			V					V
bcap31			V				V
atf4b				V				V
calr				V		V		V
zgc:55262				V				V
capn2a				V
stt3a				V				V
stt3b				V
rpn1				V				V
sec23a				V
syvn1				V				V
sec63				V
atf6				V			V	V
ubqln4				V			V	V
ube4b				V				V
herpud1				V
erlec1				V				V
ube2d1b				V				V
dnaja1				V				V
dnajb1a				V	V			V
dnajb2				V
dnajc3a				V				V
si:ch73-147o17.1				V		V		V
cul1b				V
sec31a				V
sar1ab				V
sar1b				V
preb				V
bag2				V
ssr1				V
ngly1					V
hsp70l					V
dnajb1b					V		V
sec61g						V		V
baxa						V	V	V
xbp1						V	V
p4hb						V
dad1							V
ero1a							V
plaa							V	V
sel1l							V
rbx1							V
zgc:175088							V
ube2d1a							V
dnajb12a							V
ssr4							V
eif2s1b								V
ube2g1b								V
pkz								V
hspa1b								V
+ 04130: SNARE interactions in vesicular transport	0.4	0.3	0.9	1	0.5	0.5	1.2	0.1
stx6	V			V	V
vamp8		V
stx18			V				V
bet1			V
sec22bb			V	V			V	V
ykt6				V
stx8				V
stx3a						V
stx5al							V
stx4							V
+ 04120: Ubiquitin mediated proteolysis	0.2	0	0.3	1.2	0.5	0.3	2.6	2.8
herc3	V							V
mgrn1a	V
fbxw11a		V
socs3b		V			V	V
fbxw11b			V
anapc4			V
cul4b			V
cblc			V
ube2d4			V
ube2nb			V
sae1				V			V
ddb2				V				V
vhl				V	V			V
flj11011l				V				V
anapc11				V
cul1b				V
cul5a				V
syvn1				V				V
ube2d1b				V				V
smurf2				V			V	V
ube3c				V
ube4b				V				V
socs1a					V		V
mgrn1b						V
rbx1							V
zgc:175088							V
anapc10							V	V
cdc16							V	V
anapc2							V	V
xiap							V
siah1							V
ube2d1a							V
ube2na							V
ube3b							V	V
ube2s							V
ube2l3a							V
ube2h							V	V
ube2w								V
fbxw8								V
rnf7								V
ube2g1b								V
ube2e3								V
+ 04122: Sulfur relay system	0	0	0	0.8	1.4	0	0.9	0
ctu2				V
ctu1					V		V
+ 03050: Proteasome	0.3	0	6.7	1.9	0	0.3	9.8	1.6
psmc6	V		V	V			V
psmd3			V	V			V	V
psmd12			V				V
psmd11b			V				V
psmd6			V				V
psmd14			V				V
psmd8			V				V
psmd4a			V				V
psmd4b			V				V
psmd1			V	V			V	V
psmc4			V				V
psmc3			V
psmc5			V				V
si:rp71-45k5.4			V
psma5			V				V
psma3			V	V			V
psmb6			V				V
psmb3			V				V
psmb1			V				V
psmb4			V				V
psmd11a				V
psma6l				V
psmb12				V			V
psmb2				V				V
psma2						V
psmd7							V
psmd13							V
adrm1							V	V
psmc1a							V
psmc1b							V
psme1							V
psma6b							V
psma4							V
psma8							V
psmb7							V	V
psmb5							V	V
pomp							V	V
+ 03018: RNA degradation	0.4	1.2	1.2	2.4	1.9	3.4	4.6	2.1
btg2	V	V			V	V
btg3	V		V		V	V	V	V
exosc4		V						V
exosc3		V	V			V	V
btg1		V				V
tob1b		V	V			V	V
c1d			V		V	V		V
lsm7			V				V
lsm8			V				V
hspd1			V	V			V
exosc7				V				V
skiv2l				V
exosc9				V			V	V
exosc8				V				V
mphosph6				V				V
cnot3b				V
dcp1b				V				V
smx5				V
btg4				V
si:dkey-42i9.4				V				V
zgc:103759				V				V
eno1a					V	V	V
dis3l					V		V
dcps						V	V
wdr61							V
cnot2							V	V
cnot4b							V
cnot6b							V
lsm1							V
lsm4							V
lsm5							V
lsm6							V
+ 2.4 Replication and repair	1	0.7	0.9	3.7	2.5	0.6	7.5	4.8
+ 03030: DNA replication	0	0.3	0.1	1.5	0.5	0	3.6	4.2
mcm7		V	V				V	V
lig1				V			V	V
fen1				V
zgc:110269				V				V
pole3				V
pold1				V				V
pold3					V		V
rpa3							V
ssbp1							V
pola2							V	V
mcm6							V	V
rpa1							V	V
rfc1							V	V
rfc4								V
mcm5								V
pola1								V
+ 03410: Base excision repair	0.5	0.3	0.5	1.6	0.5	0.6	1.8	1.2
ogg1	V	V
apex1			V
hmgb1a			V				V
fen1				V
zgc:110269				V				V
lig1				V			V	V
pole3				V
pold1				V				V
pold3					V		V
parp2						V
parp1							V
tdg.1							V
apex2								V
+ 03420: Nucleotide excision repair	0.4	0.2	0.4	1.7	1.1	0	4.5	2.2
ercc4	V			V			V	V
gtf2h3		V
gtf2h4			V				V
cul4b			V
gtf2h1				V			V
lig1				V			V	V
pole3				V
pold1				V				V
ddb2				V				V
cdk7					V
pold3					V		V
gtf2h2							V
ercc2							V
gtf2h5							V
rbx1							V
rfc1							V	V
rpa1							V	V
rpa3							V
rfc4								V
+ 03430: Mismatch repair	0	0	0	1.4	1.7	0	3.3	2.6
msh2				V
lig1				V			V	V
pold1				V				V
mlh1					V
pold3					V		V
rpa1							V	V
rpa3							V
rfc1							V	V
ssbp1							V
rfc4								V
+ 03440: Homologous recombination	0	0.3	0.1	0.7	1.2	0	2.8	0.4
brca2		V		V	V		V
rad51b			V				V
pold1				V				V
brip1				V
pold3					V		V
rpa1							V	V
rpa3							V
ssbp1							V
rbbp8							V
+ 03450: Non-homologous end-joining	1	0	0.5	2.4	0	0	1.2	0.4
xrcc5	V			V			V
lig4			V	V
fen1				V
zgc:110269				V				V
dclre1c							V
+ 03460: Fanconi anemia pathway	0.9	0.6	0.7	0.4	1.6	1.1	2.7	1.7
poli	V
ercc4	V			V			V	V
brca2		V		V	V		V
wdr48a		V
rev1			V
slx1b			V
her6			V
brip1				V
atrip					V	V	V	V
mlh1					V
usp1						V	V	V
fance							V	V
rpa1							V	V
rpa3							V
fan1							V
ube2t								V
+ 3. Environmental Information Processing	2.8	4	2.9	2.8	3.8	2.7	1.4	3.4
+ 3.1 Membrane transport	1.2	1.5	1.1	0.8	0.6	0.6	0.2	0.4
+ 02010: ABC transporters	1.2	1.5	1.1	0.8	0.6	0.6	0.2	0.4
abcc4	V			V
abca1b	V	V	V		V	V
abcg5		V						V
abcb6a		V
abcc2			V
abca1a			V				V	V
abcd1				V
abcc5				V
+ 3.2 Signal transduction	3.1	4.7	3.5	4	5.4	3.1	2.1	4.7
+ 04010: MAPK signaling pathway	2.1	2.3	0.5	0.9	3.3	1	0.3	1.9
nfkb2	V			V	V			V
fgfr4	V	V
insra	V
map2k6	V			V
map4k2	V		V
gadd45ga	V	V	V
gadd45ba	V	V
tgfb1a	V
il1b	V		V					V
mycb	V	V		V	V	V		V
mknk2a	V	V			V	V
mknk1	V			V			V	V
pdgfaa	V				V	V
efna3b	V	V
fgf6a	V							V
dusp4		V
dusp1		V
hrasa		V
ngfrb		V
csf1ra		V
tp53		V
mapk12b		V		V	V		V
gadd45aa		V			V
mapk8a		V
crkl		V				V
hsc70		V	V	V			V	V
igf1		V		V			V	V
igf2b		V	V
efna1a		V					V	V
kras			V	V
gna12a			V				V
erbb3b			V	V				V
cacnb1			V	V
cdc25b			V		V
mapkapk2a			V
mapk14a			V
ppp5c			V				V
pak1			V
jund			V
fosab			V		V			V
ppp3r1a			V
mknk2b			V	V		V	V	V
dusp8a				V
braf				V		V	V	V
rps6ka4				V
atf4b				V				V
mapk14b				V
hspb1				V
casp3b				V
tgfb2				V
pak2a				V				V
arrb2a				V	V	V	V	V
jun				V			V	V
srfa				V			V	V
kitlga				V
myd88				V				V
prkacab					V			V
insrb					V		V
erbb2					V
nlk1					V			V
mapk11					V
daxx					V
tnfrsf1a					V			V
hsp70l					V
ppp3cca					V
dusp7						V
rps6ka3b						V
dusp5							V
nras							V
gng12a							V
fgf1a							V
pla2g4aa								V
ikbkb								V
gadd45bb								V
tgfbr1b								V
map2k4a								V
hspa1b								V
ins								V
igf2a								V
efna1b								V
+ 04012: ErbB signaling pathway	0.7	1.4	1	1.7	2.1	2.3	0.3	2.1
shc2	V		V		V	V	V
camk2d1	V			V	V
mycb	V	V		V	V	V		V
cdkn1bb		V	V	V
mapk8a		V
crkl		V				V
camk2b1		V
hrasa		V
erbb3b			V	V				V
cdkn1a			V		V	V	V
cdkn1ba			V	V
pak1			V
kras			V	V
eif4ebp1				V				V
pak2a				V				V
plcg2				V				V
jun				V			V	V
braf				V		V	V	V
erbb2					V
src					V			V
pik3r3b						V		V
nras							V
nck2a								V
map2k4a								V
pik3cd								V
+ 04310: Wnt signaling pathway	0.2	3.6	0.1	0.9	1.9	1.7	1.1	1.7
camk2d1	V			V	V
ppardb	V
mycb	V	V		V	V	V		V
camk2b1		V
fzd4		V
fzd5		V		V			V
fzd3b		V
fzd8a		V		V		V		V
wnt5b		V
mapk8a		V
prickle1a		V				V	V	V
zgc:136929		V	V					V
fbxw11a		V
tbl1x		V
tp53		V
axin2		V				V
gbp		V	V	V		V	V	V
wnt10a		V
notum1a		V
ppp3r1a			V
prickle2b			V			V	V
ctnnbip1			V				V
fbxw11b			V
porcnl			V
rock2a				V			V	V
gpc4				V				V
vangl2				V			V	V
jun				V			V	V
ruvbl1				V	V			V
cul1b				V
ctnnb1				V
bambia				V				V
invs				V
ppp3cca					V
nlk1					V			V
prkacab					V			V
csnk1e					V		V
sfrp1a					V			V
bambib						V	V
rbx1							V
siah1							V
znrf3							V
dvl3a								V
tcf7l1a								V
lrp6								V
+ 04330: Notch signaling pathway	0.3	1.1	0.6	0.7	0.9	0.4	0.1	1.9
jag1a	V				V
zgc:136929		V	V					V
jag1b		V		V		V		V
notch3		V		V				V
her6			V
mfng			V
numb				V
lfng				V				V
dtx3					V
aph1b							V
ncor2								V
her15.2								V
dvl3a								V
+ 04340: Hedgehog signaling pathway	0.7	0.4	1.9	1.5	1.4	0.3	0.7	1.2
gpr161	V
dhh	V			V
fbxw11a		V
spop		V
gli2a			V	V				V
gli3			V
kif7			V
fbxw11b			V
hhip			V
sufu			V
bcl2a			V
cul1b				V
boc				V				V
smurf2				V			V	V
arrb2a				V	V	V	V	V
kif3a				V
csnk1e					V		V
prkacab					V			V
cdon							V	V
+ 04350: TGF-beta signaling pathway	1.3	0.3	0	1.1	0.3	0.8	0.2	1.2
mycb	V	V		V	V	V		V
id2a	V
tgfb1a	V
smad9	V
hamp	V			V	V			V
inhbab		V		V		V	V	V
smad1		V
smad3a			V
tgif1			V				V
cul1b				V
acvr2aa				V
smurf2				V			V	V
tgfb2				V
smad5				V
bambia				V				V
neo1a				V
bambib						V	V
rbx1							V
smad2								V
rock1								V
tgfbr1b								V
bmpr2a								V
nbl1								V
+ 04370: VEGF signaling pathway	0.2	0.7	0.9	0.6	2.2	0.7	0.2	0.6
shc2	V		V		V	V	V
mapk12b		V		V	V		V
hrasa		V
casp9		V
mapkapk2a			V
ppp3r1a			V
mapk14a			V
kras			V	V
plcg2				V				V
hspb1				V
mapk14b				V
ppp3cca					V
mapk11					V
src					V			V
pik3r3b						V		V
nras							V
pla2g4aa								V
pik3cd								V
+ 04371: Apelin signaling pathway	0.3	0.4	0.1	0.6	0.6	0	0.7	0.1
prkag2a	V		V
pik3cg	V				V		V
jag1a	V				V
hrasa		V
notch3		V		V				V
jag1b		V		V		V		V
acta2		V		V
calm1b		V
kras			V	V
pik3c3			V	V
smad3a			V
calm3b			V
calm2a			V
aplnrb				V
gnb1a				V
gnai2b				V
klf2a				V
klf2b				V
gabarapl2				V				V
adcy8					V		V
prkacab					V			V
prkag1							V
serpine1							V
gng12a							V
nras							V
mef2aa							V
egr1							V
calm2b							V
apln							V	V
tgfbr1b								V
smad2								V
+ 04068: FoxO signaling pathway	3.1	3.5	3	3	3.4	1	2	2.6
prkag2a	V		V
insra	V
pck1	V	V	V	V
gadd45ga	V	V	V
gadd45ba	V	V
bnip3	V
bnip4	V			V	V
sgk1	V			V
sgk2a	V	V
fbxo25	V				V			V
ccng2	V				V
tgfb1a	V
mapk8a		V
foxo3b		V	V				V
foxo1a		V	V	V	V		V	V
hrasa		V
g6pca.1		V	V
g6pca.2		V	V	V		V	V	V
irs2a		V	V			V	V
igf1		V		V			V	V
cdkn1bb		V	V	V
gadd45aa		V			V
mapk12b		V		V	V		V
fbxo32		V	V	V				V
foxo3a			V				V
kras			V	V
cdkn1a			V		V	V	V
cdkn1ba			V	V
plk2b			V
s1pr4			V
smad3a			V
mapk14a			V
setd7			V	V
braf				V		V	V	V
g6pc3				V
tnfsf10				V			V
klf2a				V
klf2b				V
gabarapl2				V				V
atg12				V				V
sgk3				V				V
mapk14b				V
tgfb2				V
insrb					V		V
ccnb1					V
csnk1e					V		V
nlk1					V			V
mapk11					V
pik3r3b						V		V
prkag1							V
nras							V
cdk2							V	V
sod2							V
ikbkb								V
ins								V
pik3cd								V
gadd45bb								V
homer1b								V
tgfbr1b								V
smad2								V
prmt1								V
+ 04020: Calcium signaling pathway	0.2	0	0.3	0.3	1.6	0.3	0	0.2
camk2d1	V			V	V
phkg1b	V	V		V
ptgfr	V		V
si:dkey-251i10.1	V		V	V				V
ppifa		V
camk2b1		V
calm1b		V
vdac1			V	V			V	V
zgc:56235			V				V
ppp3r1a			V
erbb3b			V	V				V
plcd3a			V				V
cxcr4b			V		V
calm3b			V
calm2a			V
atp2a2b			V	V
camk1gb				V				V
p2rx1				V
p2rx7				V		V		V
plcg2				V				V
phkg1a				V			V	V
atp2a2a				V
adrb2b				V
gnal				V		V		V
adcy8					V		V
ppp3cca					V
tpcn2					V
erbb2					V
mcu					V	V
adrb1					V
prkacab					V			V
orai1b						V		V
calm2b							V
plce1								V
atp2b1a								V
+ 04070: Phosphatidylinositol signaling system	1.2	0.8	2.8	1.9	0	1	1	1.7
inpp5ka	V
mtmr2	V	V	V			V	V
mtmr7b	V
mtmr7a	V		V	V
calm1b		V
inpp4ab		V		V
mtmr8		V				V
plcd3a			V				V
calm3b			V
calm2a			V
pip5k1ba			V
pi4kb			V	V
ocrl			V	V			V
pip4k2ca			V
mtm1			V
impa1			V	V			V
pik3c3			V	V
plcg2				V				V
pi4k2b				V				V
cds2				V				V
pip4k2aa				V			V	V
sacm1lb				V				V
pik3r3b						V		V
ippk							V	V
calm2b							V
plce1								V
pik3cd								V
mtmr3								V
+ 04150: mTOR signaling pathway	0.3	2	0.7	0.8	1.1	1.2	0.9	1.3
insra	V
sgk1	V			V
eif4e2	V
slc3a2b	V	V			V		V
hrasa		V
ddit4		V	V	V
ulk1a		V
slc38a9		V	V			V
igf1		V		V			V	V
wnt5b		V
wnt10a		V
fzd4		V
fzd5		V		V			V
fzd3b		V
fzd8a		V		V		V		V
kras			V	V
tsc1b			V				V
eif4ea			V	V
sec13			V				V
atp6v1g1			V				V
atp6v1b2			V
atp6v1c1b			V	V	V			V
flcn			V
deptor			V
braf				V		V	V	V
eif4ebp1				V				V
eif4e1c				V	V			V
slc3a2a				V
lamtor2				V
strada				V
insrb					V		V
tnfrsf1a					V			V
eif4ba					V	V		V
pik3r3b						V		V
rps6ka3b						V
nras							V
eif4e2rs1							V
seh1l							V
atp6v1ba							V
atp6v1f							V
pik3cd								V
tsc1a								V
ikbkb								V
atp6v1e1b								V
ins								V
lrp6								V
dvl3a								V
+ 3.3 Signaling molecules and interaction	0.6	0.8	0.4	0.1	0.5	0.9	0.1	0.8
+ 04080: Neuroactive ligand-receptor interaction	0	0	0	0	0	0	0	0
ptgfr	V		V
c3a.2	V	V		V
thraa		V
grm6b		V
npy7r		V
npy2rl		V
taar13d		V
grik5			V
grm6a			V
ghrhrl			V
s1pr2			V
s1pr4			V
taar12b			V
hcrt			V
nr3c1				V				V
p2rx1				V
p2rx7				V		V		V
mtnr1c				V
f2rl1.2				V
aplnrb				V
adrb2b				V
chrna1				V		V		V
gria4a					V
grm4					V			V
adrb1					V
prlhr2b						V	V	V
lpar3							V
apln							V	V
grid2								V
agt								V
+ 04060: Cytokine-cytokine receptor interaction	1	1.3	0.1	0	0.3	0.4	0	0.2
il6st	V
il1b	V		V					V
tgfb1a	V
cd40	V
thpo	V	V
tnfrsf1b	V	V
il2rb		V		V
inhbab		V		V		V	V	V
crfb2		V
il12rb2		V
ngfrb		V
ccl39.1		V	V
csf1ra		V
il17ra1a			V
cxcr4b			V		V
cxcl8b.3			V
tnfsf12			V
acvr2aa				V
crfb4				V				V
tgfb2				V
tnfsf10				V			V
tnfrsf19					V
tnfrsf1a					V			V
cxcr3.1						V
gdf2						V
ackr3b							V	V
bmpr2a								V
tgfbr1b								V
tnfb								V
cxcl14								V
+ 04512: ECM-receptor interaction	0	0.1	0.5	0.1	0.6	1.2	0.2	1.2
chad		V	V
tnr			V
itgb5			V				V	V
frem2a			V	V		V		V
vtna				V				V
itga5				V			V
thbs4b					V
hmmr					V
lama5						V
col2a1b						V
col1a1b							V	V
lamb1a								V
lamc1								V
col1a2								V
+ 4. Cellular Processes	3.1	3.2	3.6	4.4	6.2	3.2	4.7	7.4
+ 4.1 Transport and catabolism	1.4	2.1	3.4	4.6	2.9	2	2.7	5.2
+ 04144: Endocytosis	0.3	0.5	1	0.6	0.4	0.2	1.1	1.6
ldlra	V		V
vps37b	V			V	V	V	V	V
rab11bb	V	V	V	V			V
fgfr4	V	V
sh3gl3a	V			V
asap1a	V		V
stam		V
vps37a		V	V				V
hsc70		V	V	V			V	V
hrasa		V
grk4		V
cyth1b		V	V
cav2		V	V					V
il2rb		V		V
dnm2a			V
cblc			V
clta			V	V
cxcr4b			V		V
pip5k1ba			V
asap2a			V
ehd1b			V					V
smad3a			V
arpc5la			V
arpc1a			V				V	V
snx5			V				V
smurf2				V			V	V
cltca				V				V
cltcb				V			V	V
vps28				V				V
chmp4bb				V			V	V
pard6b				V		V		V
arf6a				V			V
sh3glb1b				V				V
arrb2a				V	V	V	V	V
git2a				V
ehd1a				V
vps26b				V
spg21				V
arpc5a				V			V
hsp70l					V
src					V			V
acap3b					V			V
ehd2b						V
vps36							V
sh3gl3b							V
pld1a							V	V
chmp7							V
vps35							V	V
rab11fip4b							V
arpc4							V
arpc4l							V
stambpb								V
ap2b1								V
hspa1b								V
chmp3								V
vps4a								V
tgfbr1b								V
smad2								V
igf2r								V
+ 04145: Phagosome	0.3	0.2	2.5	2.3	1.1	1.2	1.5	2.2
tuba4l	V
tcirg1b	V	V	V
c3a.2	V	V		V
canx		V	V	V			V	V
si:busm1-266f07.2		V		V
sec22bb			V	V			V	V
stx18			V				V
itgb5			V				V	V
pik3c3			V	V
tuba8l			V	V			V	V
tuba8l4			V	V			V	V
atp6v1g1			V				V
atp6v1b2			V
atp6v1c1b			V	V	V			V
atp6v0a2b			V
tlr4ba			V
sec61a1l			V	V
calr3a			V
calr3b			V	V				V
itga5				V			V
actb1				V				V
tubb4b				V				V
m6pr				V
hbl4				V
calr				V		V		V
mhc2dab				V
ctsla				V	V			V
zgc:55461					V	V
atp6v0cb					V
thbs4b					V
tuba2						V		V
zgc:65894						V		V
sec61g						V		V
tuba8l2							V	V
tuba8l3							V	V
atp6v0d1							V
atp6v1ba							V
atp6v1f							V
atp6v1e1b								V
+ 04142: Lysosome	0.7	0.5	0.4	1.4	2.8	1.3	0.3	2.5
tcirg1b	V	V	V
ctsh	V
tpp1	V
arsa	V				V
aga		V
sort1b		V			V			V
acp5b		V			V	V		V
sumf1		V
atp6v0a2b			V
lipf			V	V			V	V
zgc:153169			V
clta			V	V
ap1s1			V
mcoln1a			V	V	V	V	V	V
ctsla				V	V			V
sgsh				V
asah1a				V	V			V
ppt1				V				V
npc1				V
mfsd8				V				V
cltca				V				V
cltcb				V			V	V
m6pr				V
ap1m2				V
atp6v0cb					V
glb1					V	V
ap1s3b					V		V
galns						V		V
litaf						V
atp6v0d1							V
ctsa							V
gla							V
ctsba								V
lgmn								V
acp2								V
ppt2								V
igf2r								V
ap1b1								V
+ 04146: Peroxisome	0.4	1.2	1.5	3.2	0.1	1.5	3.3	2.1
ech1	V
prdx5	V				V
pex1		V					V	V
phyh		V	V	V
agxtb		V	V	V		V	V	V
dao.3		V
acsl4b		V	V	V		V	V	V
pipox			V
mvk			V	V			V	V
crata			V	V			V	V
dao.1			V
mpv17			V				V
pex7				V
agps				V			V	V
acox1				V
crot				V
dao.2				V
abcd1				V
acsl5				V
zgc:101540				V
idh1				V			V	V
prdx1				V			V	V
scp2a						V		V
hao2						V	V	V
pex19							V
idh2							V
sod2							V
slc25a17							V
gstk1								V
+ 04140: Autophagy - animal	0.6	1	1.4	1.1	0.7	0.5	0.1	1.9
bnip3	V
bnip4	V			V	V
dapk1	V
atg4a	V
irs2a		V	V			V	V
hrasa		V
ddit4		V	V	V
ulk1a		V
mapk8a		V
prkcq		V	V	V			V
vamp8		V
kras			V	V
prkcda			V			V	V
tsc1b			V				V
deptor			V
bcl2a			V
bcl2l1			V	V
pik3c3			V	V
hmgb1a			V				V
dapk2a			V	V
atg101				V				V
sh3glb1b				V				V
atg12				V				V
gabarapl2				V				V
ctsla				V	V			V
vmp1				V
wipi1					V			V
prkacab					V			V
pik3r3b						V		V
nras							V
ins								V
pik3cd								V
hif1ab								V
tsc1a								V
uvrag								V
mtmr3								V
eif2s1b								V
ctsba								V
+ 04136: Autophagy - other	0.6	0	0.2	1.5	0.7	0	0	1.5
atg4a	V
pik3c3			V	V
atg101				V				V
gabarapl2				V				V
atg12				V				V
wipi1					V			V
+ 04137: Mitophagy - animal	0.8	2	1.9	2.1	1.9	0.6	0.8	1.8
bnip3	V
bnip4	V			V	V
bnip3la	V				V
ulk1a		V
tfeb		V
tbc1d15		V	V			V	V	V
tp53		V
hrasa		V
mapk8a		V
foxo3b		V	V				V
pink1			V
mfn2			V
bcl2l1			V	V
tfe3a			V	V
kras			V	V
foxo3a			V				V
cited2			V		V	V	V	V
usp30				V
optn				V				V
gabarapl2				V				V
tomm7				V				V
tfe3b				V
atf4b				V				V
jun				V			V	V
src					V			V
tax1bp1b					V
nras							V
rhot1b								V
hif1ab								V
+ 4.2 Cell growth and death	3.7	4	3.4	3.3	5.4	2.1	4.6	5
+ 04110: Cell cycle	1	1.5	1.2	1.1	2	0.9	2.3	2.3
ywhag1	V
gadd45ga	V	V	V
gadd45ba	V	V
tgfb1a	V
mycb	V	V		V	V	V		V
mcm7		V	V				V	V
gadd45aa		V			V
tp53		V
cdkn1bb		V	V	V
cdk4		V
anapc4			V
cdkn1a			V		V	V	V
cdkn1ba			V	V
smad3a			V
cdc25b			V		V
mad1l1			V				V	V
rad21a			V
anapc11				V
cul1b				V
cdk1				V
cdc14b				V
ywhabl				V
ywhah				V				V
tgfb2				V
cdk6				V
e2f3				V
orc5					V	V	V
ccnb1					V
cdk7					V
tfdp2						V
mcm6							V	V
anapc2							V	V
cdc16							V	V
anapc10							V	V
rbx1							V
ywhae1							V
ywhaz							V
ywhaqa							V
ywhabb							V
ccna1							V	V
cdk2							V	V
mcm5								V
smc1al								V
gadd45bb								V
smad2								V
cdc6								V
smc3								V
+ 04114: Oocyte meiosis	0.7	0.9	0.5	0.7	2	0.1	2.4	1.5
camk2d1	V			V	V
cpeb3	V	V						V
ywhag1	V
ppp2r5ea	V
fbxw11a		V
camk2b1		V
calm1b		V
mapk12b		V		V	V		V
igf1		V		V			V	V
mad1l1			V				V	V
anapc4			V
fbxw11b			V
calm3b			V
calm2a			V
ppp3r1a			V
mapk14a			V
cdk1				V
anapc11				V
cul1b				V
cpeb1b				V
ywhabl				V
ywhah				V				V
mapk14b				V
ccnb1					V
ppp3cca					V
prkacab					V			V
adcy8					V		V
mapk11					V
rps6ka3b						V
anapc2							V	V
cdc16							V	V
anapc10							V	V
rbx1							V
cdk2							V	V
calm2b							V
ywhae1							V
ywhaz							V
ywhaqa							V
ywhabb							V
ar							V
smc1al								V
ppp2r5d								V
smc3								V
ins								V
+ 04210: Apoptosis	1.1	1.4	0.6	0.9	1.3	0.7	1.1	2.7
nfkbiaa	V	V
bida	V
gadd45ga	V	V	V
gadd45ba	V	V
ctsh	V
tuba4l	V
tp53		V
casp9		V
diabloa		V
gadd45aa		V			V
mapk8a		V
hrasa		V
bcl2l1			V	V
bcl2a			V
apaf1			V
cycsb			V				V
fosab			V		V			V
tuba8l			V	V			V	V
tuba8l4			V	V			V	V
kras			V	V
aifm1				V
casp3b				V
zgc:55262				V				V
capn2a				V
tnfsf10				V			V
jun				V			V	V
ctsla				V	V			V
atf4b				V				V
actb1				V				V
dffb					V
tnfrsf1a					V			V
daxx					V
pik3r3b						V		V
parp2						V
baxa						V	V	V
tuba2						V		V
endog							V
xiap							V
parp1							V
tuba8l2							V	V
tuba8l3							V	V
nras							V
nfkbiab								V
ikbkb								V
pik3cd								V
gadd45bb								V
ctsba								V
eif2s1b								V
+ 04216: Ferroptosis	2.2	1.8	1.7	2.2	3	1.9	1.1	1.4
slc3a2b	V	V			V		V
slc40a1	V				V	V
map1lc3b	V			V	V			V
map1lc3a	V				V			V
tp53		V
hmox1a		V	V	V			V	V
acsl4b		V	V	V		V	V	V
gss			V			V
slc39a14			V	V
ncoa4			V
slc3a2a				V
map1lc3c				V	V		V
acsl5				V
gclm								V
+ 04217: Necroptosis	0.7	0.5	0.7	1	0.1	0.3	1.4	2.5
jak1	V							V
si:dkey-251i10.1	V		V	V				V
il1b	V		V					V
bida	V
camk2d1	V			V	V
crfb2		V
ticam1		V
glula		V	V	V		V	V	V
glud1a		V					V
mapk8a		V
camk2b1		V
tlr4ba			V
hmgb1a			V				V
hsp90aa1.2			V				V	V
glulb			V				V	V
bcl2a			V
vdac1			V	V			V	V
zgc:56235			V				V
tnfsf10				V			V
faf1				V				V
rbck1				V				V
irf9				V				V
pygb				V
dnm1l				V
zgc:55262				V				V
capn2a				V
aifm1				V
chmp4bb				V			V	V
tnfrsf1a					V			V
baxa						V	V	V
parp2						V
xiap							V
macroh2a1							V
parp1							V
chmp7							V
jak2b								V
pkz								V
h2ax								V
pla2g4aa								V
chmp3								V
vps4a								V
+ 04115: p53 signaling pathway	2.8	2.2	1.4	1.6	3	0.7	1.6	1.4
gadd45ga	V	V	V
gadd45ba	V	V
ccng2	V				V
bida	V
ei24	V				V
sesn3	V			V	V			V
sesn1	V
gadd45aa		V			V
igf1		V		V			V	V
casp9		V
tp53		V
cdk4		V
rprma			V
cdkn1a			V		V	V	V
apaf1			V
cycsb			V				V
bcl2l1			V	V
bcl2a			V
ddb2				V				V
cdk1				V
cdk6				V
casp3b				V
gorab				V
aifm2				V				V
ppm1da					V
ccnb1					V
baxa						V	V	V
siah1							V
cdk2							V	V
rrm2							V
serpine1							V
gadd45bb								V
ccng1								V
+ 04218: Cellular senescence	1.2	2.3	3.1	1.2	2.8	0.9	2.1	1.3
mycb	V	V		V	V	V		V
map2k6	V			V
gadd45ga	V	V	V
gadd45ba	V	V
zfp36l1a	V				V		V
tgfb1a	V
si:dkey-251i10.1	V		V	V				V
tp53		V
foxo3b		V	V				V
hrasa		V
cdk4		V
mapk12b		V		V	V		V
gadd45aa		V			V
zfp36l1b		V						V
calm1b		V
foxo1a		V	V	V	V		V	V
fbxw11a		V
hipk3a			V
tsc1b			V				V
foxo3a			V				V
kras			V	V
cdkn1a			V		V	V	V
mapk14a			V
lin52			V	V	V		V
gata4			V				V
mapkapk2a			V
calm3b			V
calm2a			V
ppp3r1a			V
cxcl8b.3			V
smad3a			V
fbxw11b			V
vdac1			V	V			V	V
zgc:56235			V				V
cdk6				V
e2f3				V
mapk14b				V
cdk1				V
eif4ebp1				V				V
zgc:55262				V				V
capn2a				V
tgfb2				V
mapk11					V
ccnb1					V
ppp3cca					V
mcu					V	V
pik3r3b						V		V
lin37						V	V	V
nras							V
cdk2							V	V
ccna1							V	V
lin9							V
calm2b							V
serpine1							V
pik3cd								V
tsc1a								V
gadd45bb								V
smad2								V
tgfbr1b								V
+ 4.3 Cellular community - eukaryotes	0.9	0.2	0.2	0.7	3.6	1.7	0.7	3.2
+ 04510: Focal adhesion	0	0.2	0.1	0.6	1.1	1.6	0.3	2.3
pdgfaa	V				V	V
shc2	V		V		V	V	V
chad		V	V
cav2		V	V					V
hrasa		V
igf1		V		V			V	V
crkl		V				V
mapk8a		V
itgb5			V				V	V
mylpfb			V
tnr			V
bcl2a			V
pak1			V
itga5				V			V
myl7				V
rock2a				V			V	V
ilk				V
tln1				V
actn1				V				V
capn2a				V
vtna				V				V
braf				V		V	V	V
bcar1				V	V		V	V
jun				V			V	V
pak2a				V				V
ctnnb1				V
actb1				V				V
vaspa					V
src					V			V
thbs4b					V
erbb2					V
myl9a						V	V
pik3r3b						V		V
lama5						V
col2a1b						V
col1a1b							V	V
xiap							V
ppp1r12c								V
rock1								V
pik3cd								V
zyx								V
actn4								V
lamb1a								V
lamc1								V
col1a2								V
rapgef1b								V
+ 04520: Adherens junction	0.1	0	0	0.1	1.5	0	0	1.6
insra	V
smad3a			V
actb1				V				V
actn1				V				V
ctnnb1				V
nlk1					V			V
erbb2					V
insrb					V		V
src					V			V
ssx2ipa							V
ctnna1								V
tcf7l1a								V
smad2								V
tgfbr1b								V
actn4								V
+ 04530: Tight junction	1.4	0.2	0.2	0.4	2.6	0.5	0.5	1.5
zgc:154006	V		V
ppp2r2bb	V
msna	V						V
cldn11a	V				V
cldnd	V				V
cldn1	V	V			V
prkag2a	V		V
tuba4l	V
mapk8a		V
rap2c		V
cdk4		V
amotl2a		V	V
arhgap17b			V
arhgef18a			V	V
tuba8l			V	V			V	V
tuba8l4			V	V			V	V
actr2a			V				V
gata4			V				V
pard6b				V		V		V
rock2a				V			V	V
ppp2r2d				V
actn1				V				V
actb1				V				V
rab13				V
cldn11b				V
actr3b				V
jun				V			V	V
crb3a				V				V
prkacab					V			V
vaspa					V
src					V			V
cldn5b					V
cldn2					V
cldng					V		V
erbb2					V
hspa4a					V
micall2a						V
tuba2						V		V
myl9a						V	V
prkag1							V
tuba8l2							V	V
tuba8l3							V	V
rock1								V
actn4								V
micall2b								V
cttn								V
myh11a								V
+ 04540: Gap junction	0.3	0	0.1	0.3	2	1.2	0.4	1
tuba4l	V
pdgfaa	V				V	V
hrasa		V
tuba8l			V	V			V	V
tuba8l4			V	V			V	V
kras			V	V
gnai2b				V
cdk1				V
tubb4b				V				V
prkacab					V			V
zgc:55461					V	V
adcy8					V		V
src					V			V
adrb1					V
zgc:65894						V		V
tuba2						V		V
tuba8l2							V	V
tuba8l3							V	V
nras							V
+ 4.5 Cell motility	0.1	0.1	0.2	0.2	0.4	0.5	1.4	1.3
+ 04810: Regulation of actin cytoskeleton	0.1	0.1	0.2	0.2	0.4	0.5	1.4	1.3
msna	V						V
fgfr4	V	V
pdgfaa	V				V	V
fgf6a	V							V
limk2		V
scinlb		V
crkl		V				V
hrasa		V
arpc5la			V
arpc1a			V				V	V
pip4k2ca			V
pip5k1ba			V
mylpfb			V
pak1			V
itgb5			V				V	V
kras			V	V
gna12a			V				V
cxcr4b			V		V
arpc5a				V			V
zgc:172352				V
cyfip1				V
pip4k2aa				V			V	V
actn1				V				V
myl7				V
rock2a				V			V	V
pak2a				V				V
braf				V		V	V	V
bcar1				V	V		V	V
itga5				V			V
actb1				V				V
scinla					V
src					V			V
myl9a						V	V
pik3r3b						V		V
arpc4							V
arpc4l							V
pfn2l							V
cfl1							V
gsna							V	V
gng12a							V
nras							V
fgf1a							V
tmsb4x								V
actn4								V
ppp1r12c								V
rock1								V
arhgef7b								V
pik3cd								V
ins								V
+ 5. Organismal Systems	4	5.8	3.4	3.1	3.7	3.2	2.6	4.6
+ 5.1 Immune system	2.5	3.3	2.2	2.4	1.9	0.8	0.4	4
+ 04620: Toll-like receptor signaling pathway	1.6	1.9	0.5	0.7	0.8	0.2	0	1.6
cd40	V
il1b	V		V					V
nfkbiaa	V	V
tlr5b	V
map2k6	V			V
irf7		V		V				V
mapk12b		V		V	V		V
mapk8a		V
ikbke		V
ticam1		V
crfb2		V
mapk14a			V
cxcl8b.3			V
tlr4ba			V
fosab			V		V			V
myd88				V				V
mapk14b				V
irf3				V
jun				V			V	V
mapk11					V
pik3r3b						V		V
ikbkb								V
nfkbiab								V
pik3cd								V
map2k4a								V
+ 04621: NOD-like receptor signaling pathway	0.4	1.1	2	1.9	0.5	0.5	0.7	2.3
il1b	V		V					V
jak1	V							V
nfkbiaa	V	V
mapk8a		V
mapk12b		V		V	V		V
ikbke		V
irf7		V		V				V
crfb2		V
ticam1		V
hsp90aa1.2			V				V	V
mapk14a			V
tlr4ba			V
vdac1			V	V			V	V
zgc:56235			V				V
txn			V				V
sting1			V
prkcda			V			V	V
bcl2a			V
bcl2l1			V	V
mfn2			V
cxcl8b.3			V
mapk14b				V
p2rx7				V		V		V
jun				V			V	V
irf3				V
myd88				V				V
txnipa				V				V
rbck1				V				V
gabarapl2				V				V
atg12				V				V
irf9				V				V
dnm1l				V
mapk11					V
mcu					V	V
gbp1							V
xiap							V
ikbkb								V
nfkbiab								V
ctsba								V
+ 04622: RIG-I-like receptor signaling pathway	0.2	2.2	0.7	1.1	1.3	0.3	0	0.8
nfkbiaa	V	V
otud5a		V			V
ikbke		V
irf7		V		V				V
mapk8a		V
mapk12b		V		V	V		V
ifih1			V	V		V		V
sting1			V
mapk14a			V
cxcl8b.3			V
irf3				V
atg12				V				V
mapk14b				V
mapk11					V
ikbkb								V
nfkbiab								V
+ 04623: Cytosolic DNA-sensing pathway	1.7	1.3	0.8	1.4	0	0.5	0	3.6
il1b	V		V					V
nfkbiaa	V	V
polr3h	V		V					V
ikbke		V
irf7		V		V				V
sting1			V
irf3				V
polr3c				V		V
polr1c				V
polr2k				V				V
ikbkb								V
nfkbiab								V
polr3k								V
polr2eb								V
polr2h								V
polr2l								V
+ 04625: C-type lectin receptor signaling pathway	0.9	1.1	1.3	0.4	1.5	0.4	0.2	1.4
il1b	V		V					V
nfkbiaa	V	V
irf1b	V
nfkb2	V			V	V			V
hrasa		V
ikbke		V
calm1b		V
mapk12b		V		V	V		V
mapk8a		V
pak1			V
kras			V	V
mapkapk2a			V
prkcda			V			V	V
ppp3r1a			V
calm3b			V
calm2a			V
mapk14a			V
irf9				V				V
plcg2				V				V
mapk14b				V
jun				V			V	V
src					V			V
ppp3cca					V
mapk11					V
pik3r3b						V		V
nras							V
calm2b							V
ptpn11b								V
ikbkb								V
nfkbiab								V
pik3cd								V
+ 04672: Intestinal immune network for IgA production	1.2	0.4	0.2	0.4	0.6	0	0	0
tgfb1a	V
cd40	V
si:busm1-266f07.2		V		V
cxcr4b			V		V
mhc2dab				V
+ 5.2 Endocrine system	4.4	6.4	3.6	2.7	4.3	4.1	3.6	3.7
+ 04910: Insulin signaling pathway	3.5	4.1	3.3	1.3	3.8	4	3.3	2.9
socs2	V	V	V
mknk2a	V	V			V	V
mknk1	V			V			V	V
prkag2a	V		V
phkg1b	V	V		V
prkar2ab	V
acaca	V		V
eif4e2	V
shc2	V		V		V	V	V
insra	V
pck1	V	V	V	V
hkdc1	V	V	V	V	V	V	V	V
gck	V	V	V		V	V	V	V
mapk8a		V
socs3b		V			V	V
ppp1r3ca		V				V		V
calm1b		V
foxo1a		V	V	V	V		V	V
hrasa		V
g6pca.1		V	V
g6pca.2		V	V	V		V	V	V
rhoq		V			V		V
srebf1		V
crkl		V				V
irs2a		V	V			V	V
tsc1b			V				V
mknk2b			V	V		V	V	V
ppp1r3b			V
calm3b			V
calm2a			V
kras			V	V
eif4ea			V	V
fbp1a			V
exoc7			V
phkg1a				V			V	V
eif4ebp1				V				V
pygb				V
eif4e1c				V	V			V
braf				V		V	V	V
g6pc3				V
socs1a					V		V
ppp1r3cb					V
gys1					V
prkacab					V			V
insrb					V		V
fbp1b						V		V
pik3r3b						V		V
prkag1							V
zgc:77112							V
calm2b							V
nras							V
eif4e2rs1							V
hk1							V
flot2b							V	V
tsc1a								V
ikbkb								V
ins								V
prkar1ab								V
pik3cd								V
rapgef1b								V
+ 04920: Adipocytokine signaling pathway	3.1	4	1.6	0.6	1	1.6	0.8	1.3
nfkbiaa	V	V
nfkbie	V				V
pck1	V	V	V	V
prkag2a	V		V
pparab	V
rxrgb	V	V
rxraa	V	V
tnfrsf1b	V	V
socs3b		V			V	V
g6pca.1		V	V
g6pca.2		V	V	V		V	V	V
acsl4b		V	V	V		V	V	V
prkcq		V	V	V			V
mapk8a		V
irs2a		V	V			V	V
adipor2			V				V	V
g6pc3				V
acsl5				V
tnfrsf1a					V			V
prkag1							V
nfkbiab								V
ptpn11b								V
ikbkb								V
jak2b								V
+ 03320: PPAR signaling pathway	3.5	3.7	2.8	2.3	0.7	3.4	1.6	1.4
pck1	V	V	V	V
fabp2	V	V	V	V
fabp7a	V		V		V		V
pparab	V
rxrgb	V	V
rxraa	V	V
ppardb	V
scd	V		V	V	V	V	V	V
plin2		V				V
slc27a6		V	V			V	V
acsl4b		V	V	V		V	V	V
si:dkey-91i10.3		V				V
ubb		V	V
me1		V
aqp7			V
zgc:172295			V
me3			V
zgc:101540				V
acsl5				V
acox1				V
ilk				V
fads2				V				V
dbi				V			V
scp2a						V		V
lpl						V		V
pparg							V	V
ubc							V
slc27a1a								V
+ 04912: GnRH signaling pathway	0.6	0.9	0.5	0.7	2.4	0.1	0.9	0.7
camk2d1	V			V	V
map2k6	V			V
mmp14b	V			V	V			V
camk2b1		V
mapk12b		V		V	V		V
calm1b		V
hrasa		V
mapk8a		V
prkcda			V			V	V
mapk14a			V
calm3b			V
calm2a			V
mmp2			V
kras			V	V
atf4b				V				V
mapk14b				V
jun				V			V	V
adcy8					V		V
mapk11					V
src					V			V
prkacab					V			V
calm2b							V
pld1a							V	V
nras							V
egr1							V
pla2g4aa								V
map2k4a								V
+ 04914: Progesterone-mediated oocyte maturation	0.1	0.6	0.6	1	2.1	0.8	2.2	2.8
cpeb3	V	V						V
igf1		V		V			V	V
mapk12b		V		V	V		V
mapk8a		V
kras			V	V
anapc4			V
mad1l1			V				V	V
cdc25b			V		V
hsp90aa1.2			V				V	V
mapk14a			V
cpeb1b				V
cdk1				V
anapc11				V
gnai2b				V
mapk14b				V
braf				V		V	V	V
adcy8					V		V
ccnb1					V
prkacab					V			V
mapk11					V
pik3r3b						V		V
rps6ka3b						V
anapc2							V	V
cdc16							V	V
anapc10							V	V
cdk2							V	V
ccna1							V	V
kif22							V
ins								V
pik3cd								V
stk10								V
+ 04916: Melanogenesis	0	2.4	0	0.7	0.6	0.1	0.1	0.1
camk2d1	V			V	V
camk2b1		V
calm1b		V
fzd4		V
fzd5		V		V			V
fzd3b		V
fzd8a		V		V		V		V
creb3l2		V		V
wnt5b		V
wnt10a		V
hrasa		V
calm3b			V
calm2a			V
kras			V	V
gnai2b				V
kitlga				V
creb3l3a				V				V
ctnnb1				V
prkacab					V			V
adcy8					V		V
calm2b							V
nras							V
dvl3a								V
tcf7l1a								V
+ 5.3 Circulatory system	0	0.3	0.1	0.2	0.2	0.6	0.5	0.2
+ 04270: Vascular smooth muscle contraction	0	0.3	0.1	0.2	0.2	0.6	0.5	0.2
prkcq		V	V	V			V
acta2		V		V
calm1b		V
cald1a		V
prkcda			V			V	V
gna12a			V				V
calm3b			V
calm2a			V
rock2a				V			V	V
arhgef11				V
pla2g6				V
pla2g1b				V
braf				V		V	V	V
adcy8					V		V
prkacab					V			V
myl9a						V	V
calm2b							V
ppp1r12c								V
rock1								V
pla2g4aa								V
agt								V
+ 6. Human Diseases	NAN	NAN	NAN	NAN	NAN	NAN	NAN	NAN

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