Tools

Score Type:
Meta Z-score
Z-score
No. of Genes

HisBIM: A Hierarchical System Biology Model
System/Subsystem/Pathway	Z-score
	H_GSE27205_IPSC_up	H_GSE27205_IPSC_down	H_GSE58316_LBs_up	H_GSE58316_LBs_down
	107/212	414/831	57/132	74/128
+ 1. Metabolism	4.1	11.1	1.1	2.5
+ 1.0 Global and overview maps	0.6	7.5	0	0.3
+ 01100: Metabolic pathways	0.5	5.1	0	0.7
CYP2A6	V
ANPEP	V
ASPA	V
PDE1A	V
FUT8	V
PLPP3	V
ADH1A	V
ADH1B	V
AOX1	V
PTGIS	V
PTGDS	V
ACSM2B	V
TPI1	V
ACSS3	V
ATP6V0A1	V
SDHC		V
CTH		V
PPAT		V
DLD		V
ELOVL2		V
TECR		V
SCD		V
ELOVL6		V
RRM1		V
RRM2		V
GSTM1		V
GSTM4		V
ALDH7A1		V
PGM2		V
PIK3C2B		V
KYNU		V
ACADM		V
GATM		V		V
GOT2		V
LDHB		V
EPRS		V
PNP		V
CDA		V
PDE3A		V
PDE4D		V
PDE8A		V
NME1		V
NPR1		V
GDA		V
HPRT1		V
PAICS		V
TST		V
MDH1		V
OXCT1		V
GLO1		V
PFKFB2		V
KHK		V
GCNT2		V
MGAT4A		V
PDHA1		V
GGCT		V
GCLC		V
ALPP		V
RIMKLB		V
ETNPPL		V
HMGCS1		V
DGKD		V
CBS		V
MTHFD2		V
MTHFD1		V
FDFT1		V
PGD		V
NANS		V
PHGDH		V
PSAT1		V
MAT2A		V
AMD1		V
DHTKD1		V
CKB		V
ASRGL1		V
CPS1		V
SAT1		V
ACAT2		V
ACSL3		V
PPT1		V
SQLE		V
CYP51A1		V
MSMO1		V
EBP		V
DHCR7		V
ME1		V
CTPS1		V
TYMS		V
SELENOI		V
PLA2G4A		V
PHOSPHO1		V
PTGS2		V
NUDT12		V
NADK2		V
IDI1		V
ALG8		V
PIGA		V
B3GNT5		V
CMBL		V
ACSM3		V
LTA4H		V
PRPS1		V
GART		V
IDH1		V
IDH3A		V
RDH10		V
ODC1		V
AGL		V
CSGALNACT1		V
NQO1		V
HMGCR		V
UQCRQ		V
COX7A2		V
COX7B		V
ATP5MG		V
NDUFS1		V
PLD1			V
GPX7			V
LDHC			V
GUCY1A1			V
LPIN1			V
BCKDHA				V
GSTM2				V
MGST1				V
UPP1				V
ALOX5				V
NAPRT				V
GCNT3				V
GCNT1				V
ACP5				V
+ 01200: Carbon metabolism	0.3	3.5	0	0
TPI1	V
PGD		V
DLD		V
PDHA1		V
MDH1		V
SDHC		V
IDH1		V
IDH3A		V
ACAT2		V
PHGDH		V
PSAT1		V
PRPS1		V
CPS1		V
ME1		V
GOT2		V
+ 01210: 2-Oxocarboxylic acid metabolism	0	2.1	0	0
GOT2		V
IDH1		V
IDH3A		V
+ 01212: Fatty acid metabolism	0	3	0	0
ELOVL6		V
TECR		V
ACAT2		V
SCD		V
ELOVL2		V
ACSL3		V
ACADM		V
PPT1		V
+ 01230: Biosynthesis of amino acids	0.6	3.2	0	0
TPI1	V
PRPS1		V
PHGDH		V
PSAT1		V
GOT2		V
CTH		V
IDH1		V
IDH3A		V
CPS1		V
MAT2A		V
CBS		V
+ 1.1 Carbohydrate metabolism	1.6	4.7	0.9	0.7
+ 00010: Glycolysis / Gluconeogenesis	2.1	1.4	0.9	0
ADH1A	V
ADH1B	V
TPI1	V
ALDH7A1		V
PDHA1		V
LDHB		V
PGM2		V
DLD		V
LDHC			V
+ 00020: Citrate cycle (TCA cycle)	0	3.2	0	0
DLD		V
IDH1		V
IDH3A		V
MDH1		V
PDHA1		V
SDHC		V
+ 00030: Pentose phosphate pathway	0	1.5	0	0
PGM2		V
PRPS1		V
PGD		V
+ 00040: Pentose and glucuronate interconversions	0	0	0	0
+ 00051: Fructose and mannose metabolism	1	0.8	0	1.3
TPI1	V
KHK		V
PFKFB2		V
PFKFB4				V
+ 00052: Galactose metabolism	0	0.3	0	0
PGM2		V
+ 00053: Ascorbate and aldarate metabolism	0	0.4	0	0
ALDH7A1		V
+ 00500: Starch and sucrose metabolism	0	0.7	0	0
PGM2		V
AGL		V
+ 00520: Amino sugar and nucleotide sugar metabolism	0	0.5	0	0
NANS		V
PGM2		V
+ 00620: Pyruvate metabolism	0	3.7	1.2	0
PDHA1		V
GLO1		V
ME1		V
MDH1		V
LDHB		V
ALDH7A1		V
ACAT2		V
DLD		V
LDHC			V
+ 00630: Glyoxylate and dicarboxylate metabolism	0	1.5	0	0
MDH1		V
ACAT2		V
DLD		V
+ 00640: Propanoate metabolism	1	1.3	1.3	1.3
ACSS3	V
LDHB		V
ACAT2		V
DLD		V
LDHC			V
BCKDHA				V
+ 00650: Butanoate metabolism	1.1	2.2	0	0
ACSM2B	V
OXCT1		V
HMGCS1		V
ACAT2		V
ACSM3		V
+ 00562: Inositol phosphate metabolism	0.6	0	0	0
TPI1	V
PIK3C2B		V
+ 1.2 Energy metabolism	0.2	1.3	0	0
+ 00190: Oxidative phosphorylation	0.3	0.7	0	0
ATP6V0A1	V
NDUFS1		V
COX7B		V
COX7A2		V
UQCRQ		V
ATP5MG		V
SDHC		V
+ 00910: Nitrogen metabolism	0	0.6	0	0
CPS1		V
+ 00920: Sulfur metabolism	0	0.9	0	0
TST		V
+ 1.3 Lipid metabolism	2.2	4.5	1.2	0.2
+ 00061: Fatty acid biosynthesis	0	0.6	0	0
ACSL3		V
+ 00062: Fatty acid elongation	0	2.8	0	0
PPT1		V
TECR		V
THEM4		V
ELOVL2		V
ELOVL6		V
+ 00071: Fatty acid degradation	1.7	1.6	0	0
ADH1A	V
ADH1B	V
ACADM		V
ACAT2		V
ACSL3		V
ALDH7A1		V
+ 00072: Synthesis and degradation of ketone bodies	0	2.7	0	0
HMGCS1		V
ACAT2		V
OXCT1		V
+ 00100: Steroid biosynthesis	0	3.9	0	0
EBP		V
DHCR7		V
CYP51A1		V
MSMO1		V
FDFT1		V
SQLE		V
+ 00120: Primary bile acid biosynthesis	1.4	0	0	0
CH25H	V
+ 00140: Steroid hormone biosynthesis	0.7	0	0	0
AKR1C2	V
+ 00561: Glycerolipid metabolism	0.7	0.3	0.9	0
PLPP3	V
ALDH7A1		V
DGKD		V
LPIN1			V
+ 00564: Glycerophospholipid metabolism	1.1	1.6	1.5	0
PLPP3	V
LYPLA2	V
PLA2G4A		V
DGKD		V
PHOSPHO1		V
SELENOI		V
LYPLA1		V
LPGAT1		V
ETNPPL		V
LPIN1			V
PLD1			V
+ 00565: Ether lipid metabolism	0.8	0.5	1.1	0
PLPP3	V
SELENOI		V
PLA2G4A		V
PLD1			V
+ 00600: Sphingolipid metabolism	0.8	0	0	0
PLPP3	V
+ 00590: Arachidonic acid metabolism	1.4	0.7	0.9	1
PTGIS	V
PTGDS	V
PTGS2		V
PLA2G4A		V
LTA4H		V
GPX7			V
ALOX5				V
+ 00591: Linoleic acid metabolism	0	0.4	0	0
PLA2G4A		V
+ 00592: alpha-Linolenic acid metabolism	0	0.4	0	0
PLA2G4A		V
+ 01040: Biosynthesis of unsaturated fatty acids	0	2.2	0	0
ELOVL2		V
TECR		V
ELOVL6		V
SCD		V
+ 1.4 Nucleotide metabolism	0.2	4.3	0.4	0.7
+ 00230: Purine metabolism	0.3	3.5	0.5	0
PDE1A	V
RRM1		V
RRM2		V
PRPS1		V
PPAT		V
GART		V
PAICS		V
PDE3A		V
NME1		V
PNP		V
HPRT1		V
GDA		V
NPR1		V
PGM2		V
PDE4D		V
PDE8A		V
GUCY1A1			V
+ 00240: Pyrimidine metabolism	0	2.5	0	1
RRM1		V
RRM2		V
NME1		V
CTPS1		V
CDA		V
PNP		V
TYMS		V
UPP1				V
+ 1.5 Amino acid metabolism	1.8	6.5	0.6	0.9
+ 00250: Alanine, aspartate and glutamate metabolism	1	2.4	0	0
ASPA	V
ASRGL1		V
GOT2		V
CPS1		V
PPAT		V
RIMKLB		V
+ 00260: Glycine, serine and threonine metabolism	0	3.2	0	1.2
ALDH7A1		V
PHGDH		V
CBS		V
CTH		V
GATM		V		V
PSAT1		V
DLD		V
+ 00270: Cysteine and methionine metabolism	0	4.5	1.1	0
AMD1		V
CTH		V
CBS		V
MAT2A		V
GOT2		V
TST		V
LDHB		V
MDH1		V
GCLC		V
PHGDH		V
PSAT1		V
LDHC			V
+ 00280: Valine, leucine and isoleucine degradation	0.8	2.4	0	1.1
AOX1	V
DLD		V
ACAT2		V
HMGCS1		V
OXCT1		V
ALDH7A1		V
ACADM		V
BCKDHA				V
+ 00290: Valine, leucine and isoleucine biosynthesis	0	0	0	0
+ 00310: Lysine degradation	0	2.1	1	0
ALDH7A1		V
DLD		V
DHTKD1		V
ACAT2		V
EZH2		V
SUV39H1		V
PLOD2			V
+ 00220: Arginine biosynthesis	0	1.2	0	0
CPS1		V
GOT2		V
+ 00330: Arginine and proline metabolism	0	2.8	0	1.1
GATM		V		V
ALDH7A1		V
AMD1		V
SAT1		V
CKB		V
GOT2		V
ODC1		V
+ 00340: Histidine metabolism	1.2	0.5	0	0
ASPA	V
ALDH7A1		V
+ 00350: Tyrosine metabolism	2.7	0.3	0	0
AOX1	V
ADH1A	V
ADH1B	V
GOT2		V
+ 00360: Phenylalanine metabolism	0	0.7	0	0
GOT2		V
+ 00380: Tryptophan metabolism	0.9	2.1	0	0
AOX1	V
ACAT2		V
DLD		V
DHTKD1		V
KYNU		V
ALDH7A1		V
+ 00400: Phenylalanine, tyrosine and tryptophan biosynthesis	0	1.3	0	0
GOT2		V
+ 1.6 Metabolism of other amino acids	0.3	2.1	0.4	0.7
+ 00410: beta-Alanine metabolism	0	0.3	0	0
ALDH7A1		V
+ 00430: Taurine and hypotaurine metabolism	0	0	0	0
+ 00440: Phosphonate and phosphinate metabolism	0	1.2	0	0
SELENOI		V
+ 00450: Selenocompound metabolism	0	0.6	0	0
CTH		V
+ 00471: D-Glutamine and D-glutamate metabolism	0	0	0	0
+ 00472: D-Arginine and D-ornithine metabolism	0	0	0	0
+ 00480: Glutathione metabolism	0.7	3.4	1	1.9
ANPEP	V
IDH1		V
GCLC		V
GGCT		V
GSTM1		V
GSTM4		V
PGD		V
ODC1		V
RRM1		V
RRM2		V
GPX7			V
GSTM2				V
MGST1				V
+ 1.7 Glycan biosynthesis and metabolism	0.6	1	0.4	0.7
+ 00510: N-Glycan biosynthesis	0.8	0.5	0	0
FUT8	V
MGAT4A		V
ALG8		V
+ 00512: Mucin type O-glycan biosynthesis	0	0	0	2.4
GCNT3				V
GCNT1				V
+ 00515: Mannose type O-glycan biosynthesis	0	0	0	0
+ 00514: Other types of O-glycan biosynthesis	0	0	0	0
+ 00532: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0	0.6	1.5	0
CSGALNACT1		V
UST			V
+ 00534: Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0	0.5	0	0
HS6ST2		V
+ 00533: Glycosaminoglycan biosynthesis - keratan sulfate	1.5	0	0	0
FUT8	V
+ 00531: Glycosaminoglycan degradation	0	0	0	0
+ 00563: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0	0.5	0	0
PIGA		V
+ 00601: Glycosphingolipid biosynthesis - lacto and neolacto series	0	1	0	0
GCNT2		V
B3GNT5		V
+ 00603: Glycosphingolipid biosynthesis - globo and isoglobo series	0	0	0	0
+ 00604: Glycosphingolipid biosynthesis - ganglio series	0	0	0	0
+ 00511: Other glycan degradation	0	0.6	0	0
FUCA1		V
+ 1.8 Metabolism of cofactors and vitamins	1.9	2.4	0	0.9
+ 00730: Thiamine metabolism	0	0.7	0	0
ALPP		V
+ 00740: Riboflavin metabolism	0	0	0	1.9
ACP5				V
+ 00750: Vitamin B6 metabolism	1.9	1.2	0	0
AOX1	V
PSAT1		V
+ 00760: Nicotinate and nicotinamide metabolism	1.1	1.5	0	1.3
AOX1	V
NUDT12		V
PNP		V
NADK2		V
NAPRT				V
+ 00770: Pantothenate and CoA biosynthesis	0	0	0	0
+ 00780: Biotin metabolism	0	0	0	0
+ 00785: Lipoic acid metabolism	0	0	0	0
+ 00790: Folate biosynthesis	0	1.1	0	0
GGH		V
ALPP		V
+ 00670: One carbon pool by folate	0	2.6	0	0
GART		V
MTHFD2		V
MTHFD1		V
TYMS		V
+ 00830: Retinol metabolism	2.7	0.1	0	0
ADH1A	V
ADH1B	V
AOX1	V
CYP2A6	V
RDH10		V
+ 00860: Porphyrin and chlorophyll metabolism	0.9	0.2	0	0
HEPH	V
EPRS		V
+ 00130: Ubiquinone and other terpenoid-quinone biosynthesis	0	0.9	0	0
NQO1		V
+ 1.9 Metabolism of terpenoids and polyketides	0	2.4	0	0
+ 00900: Terpenoid backbone biosynthesis	0	2.4	0	0
ACAT2		V
HMGCS1		V
HMGCR		V
IDI1		V
+ 1.10 Biosynthesis of other secondary metabolites	1.4	0	0	0
+ 00232: Caffeine metabolism	1.9	0	0	0
CYP2A6	V
+ 00524: Neomycin, kanamycin and gentamicin biosynthesis	0	0	0	0
+ 1.11 Xenobiotics biodegradation and metabolism	3.3	1.6	0	3.4
+ 00980: Metabolism of xenobiotics by cytochrome P450	2	0.2	0	1.7
ADH1A	V
ADH1B	V
CYP2A6	V
GSTM1		V
GSTM4		V
GSTM2				V
MGST1				V
+ 00982: Drug metabolism - cytochrome P450	3.3	0.2	0	1.7
FMO4	V
ADH1A	V
ADH1B	V
CYP2A6	V
AOX1	V
GSTM1		V
GSTM4		V
GSTM2				V
MGST1				V
+ 00983: Drug metabolism - other enzymes	0.5	2.3	0	2.4
CYP2A6	V
TPMT		V
HPRT1		V
CDA		V
NME1		V
RRM1		V
RRM2		V
GSTM1		V
GSTM4		V
UPP1				V
GSTM2				V
MGST1				V
+ 2. Genetic Information Processing	0	10.2	0.3	0.6
+ 2.1 Transcription	0	1.1	0	0
+ 03020: RNA polymerase	0	0	0	0
+ 03022: Basal transcription factors	0	0	0	0
+ 03040: Spliceosome	0	1.9	0	0
DDX46		V
SNRPD1		V
SF3B6		V
SRSF3		V
RBM22		V
LSM5		V
LSM8		V
PRPF3		V
MAGOH		V
PRPF38A		V
+ 2.2 Translation	0	5.8	0	1
+ 03010: Ribosome	0	1.9	0	1.2
RPS29		V
RPS24		V
RPS25		V
MRPL3		V
MRPL24		V
RPL4		V
RPL14		V
MRPL21		V
MRPL33		V
MRPS17		V
RPS4Y2				V
RPS4Y1				V
+ 00970: Aminoacyl-tRNA biosynthesis	0	3	0	0
IARS		V
FARSB		V
RARS		V
LARS		V
TARS		V
WARS		V
EPRS		V
+ 03013: RNA transport	0	4.3	0	1.1
XPOT		V
XPO1		V
MAGOH		V
NXT2		V
NUP155		V
NUP107		V
SEH1L		V
NUP43		V
NUP210		V
NDC1		V
NUP88		V
PRMT5		V
EEF1A2		V		V
EIF1AX		V
EIF3E		V
EIF3J		V
POP7		V
EIF2S3		V
EIF4A1		V
EIF4E		V
EIF1AY				V
+ 03015: mRNA surveillance pathway	0	0.3	0	0
MAGOH		V
NXT2		V
CPSF3		V
+ 03008: Ribosome biogenesis in eukaryotes	0	3.5	0	0
XPO1		V
NOP58		V
FBL		V
DKC1		V
DROSHA		V
POP7		V
GNL3		V
NXT2		V
UTP6		V
WDR36		V
WDR3		V
+ 2.3 Folding, sorting and degradation	0	2.7	0.5	0.2
+ 03060: Protein export	0	1.1	1.5	0
IMMP2L		V
SEC61G		V
SEC11C			V
+ 04141: Protein processing in endoplasmic reticulum	0	0.1	0	0
SEC61G		V
ERO1B		V
HSP90AA1		V
HSPA4L		V
+ 04130: SNARE interactions in vesicular transport	0	0.3	0	0
VAMP8		V
+ 04120: Ubiquitin mediated proteolysis	0	0.9	0	0.5
SKP2		V
KLHL13		V
ANAPC10		V
CDC23		V
CDC20		V
FANCL		V
BRCA1		V
BIRC7				V
+ 04122: Sulfur relay system	0	1	0	0
TST		V
+ 03050: Proteasome	0	2.5	0	0
PSMD12		V
PSMD14		V
SEM1		V
PSMA4		V
PSMA5		V
PSMA3		V
+ 03018: RNA degradation	0	1.2	0	0
PNPT1		V
EXOSC2		V
EXOSC9		V
LSM5		V
LSM8		V
+ 2.4 Replication and repair	0	10.8	0	0
+ 03030: DNA replication	0	8	0	0
FEN1		V
RNASEH2A		V
RFC2		V
RFC4		V
RFC3		V
RFC5		V
MCM5		V
POLD3		V
SSBP1		V
MCM2		V
MCM3		V
MCM4		V
POLA1		V
POLA2		V
PRIM1		V
POLE2		V
MCM6		V
MCM7		V
+ 03410: Base excision repair	0	2.5	0	0
FEN1		V
PARP1		V
POLE2		V
POLD3		V
NEIL3		V
+ 03420: Nucleotide excision repair	0	2.4	0	0
RFC2		V
RFC3		V
RFC4		V
RFC5		V
POLE2		V
POLD3		V
+ 03430: Mismatch repair	0	5.2	0	0
MSH2		V
POLD3		V
MSH6		V
EXO1		V
RFC2		V
RFC3		V
RFC4		V
RFC5		V
SSBP1		V
+ 03440: Homologous recombination	0	4.1	0	0
BLM		V
SEM1		V
XRCC2		V
POLD3		V
SSBP1		V
BRCA1		V
RBBP8		V
BRIP1		V
TOPBP1		V
+ 03450: Non-homologous end-joining	0	1.6	0	0
PRKDC		V
FEN1		V
+ 03460: Fanconi anemia pathway	0	4.7	0	0
FANCM		V
FANCA		V
FANCB		V
FANCC		V
FANCD2		V
FANCI		V
FANCL		V
BLM		V
BRIP1		V
BRCA1		V
USP1		V
UBE2T		V
+ 3. Environmental Information Processing	5.9	2.7	3.1	5.3
+ 3.1 Membrane transport	2.5	0.5	0	0
+ 02010: ABC transporters	2.5	0.5	0	0
ABCA9	V
ABCA6	V
ABCA1	V
ABCD3		V
ABCB7		V
+ 3.2 Signal transduction	5.5	3.3	3.6	5.2
+ 04010: MAPK signaling pathway	2.4	0.9	0.2	1.5
KIT	V
PDGFRA	V
PDGFRB	V
IL1R1	V
FGF10	V
NTF3	V
PGF	V
PDGFD	V
DUSP4		V
DUSP5		V
DUSP6		V
PTPRR		V
PLA2G4A		V
STMN1		V
NRAS		V
ERBB3		V
NR4A1		V
IL1B		V
ARRB1		V
MYC		V
EREG		V
AREG		V
MAP3K20			V
IL1A				V
TNF				V
NFATC1				V
VEGFA				V
+ 04012: ErbB signaling pathway	0	1.4	0	0
ERBB3		V
EREG		V
NRG4		V
MYC		V
AREG		V
NRAS		V
+ 04014: Ras signaling pathway	2.5	0	0.7	1.3
FGF10	V
NTF3	V
PGF	V
PDGFD	V
KIT	V
PDGFRA	V
PDGFRB	V
NRAS		V
PLA2G4A		V
ETS2		V
CALM2		V
PLD1			V
GNG11			V
VEGFA				V
RALB				V
PLA1A				V
+ 04015: Rap1 signaling pathway	2.6	0.1	0.3	1.4
APBB1IP	V
FGF10	V
PGF	V
PDGFD	V
KIT	V
PDGFRA	V
PDGFRB	V
PFN2		V
LPAR3		V
PRKD3		V
NRAS		V
CALM2		V
ID1		V
CDH1			V
VEGFA				V
RAP1GAP				V
RALB				V
+ 04310: Wnt signaling pathway	2.1	0	1	1.7
PRICKLE1	V
DKK2	V
SFRP1	V
SFRP4	V
WNT2	V		V
FZD3		V
MYC		V
RUVBL1		V
BAMBI			V
NFATC1				V
GPC4				V
WNT10A				V
+ 04330: Notch signaling pathway	0	0	0	0
+ 04340: Hedgehog signaling pathway	0.8	0.5	0	0
CDON	V
CSNK1G3		V
ARRB1		V
+ 04350: TGF-beta signaling pathway	1.1	0.9	1.5	0.7
FST	V
FMOD	V
SMAD2		V
MYC		V
RBL1		V
ID1		V
BMP6		V
ID2			V
BAMBI			V
TNF				V
+ 04390: Hippo signaling pathway	0.2	1	1.7	1.1
WNT2	V		V
BIRC5		V
AREG		V
DLG2		V
SMAD2		V
FZD3		V
MYC		V
BMP6		V
ID1		V
CDH1			V
ID2			V
TEAD4				V
WNT10A				V
+ 04392: Hippo signaling pathway - multiple species	0	0	0	1.4
TEAD4				V
+ 04370: VEGF signaling pathway	0	1.2	0	1
PTGS2		V
PLA2G4A		V
NRAS		V
CASP9		V
VEGFA				V
+ 04371: Apelin signaling pathway	0.8	0.6	1.2	0.5
MYLK	V
SLC8A1	V
PRKAA2		V
ITPR1		V
ITPR2		V
NRAS		V
SMAD2		V
CALM2		V
GNG11			V
CDH1			V
SLC8A3				V
+ 04064: NF-kappa B signaling pathway	1	0.2	0	3.5
IL1R1	V
EDA2R	V
IL1B		V
PARP1		V
PTGS2		V
TNF				V
CARD11				V
SYK				V
LTA				V
LTB				V
+ 04668: TNF signaling pathway	1	0.1	2.1	1.4
CREB3L1	V
MMP3	V
IL1B		V
PTGS2		V
CREB5			V
CCL20			V
IL18R1			V
TNF				V
LTA				V
+ 04066: HIF-1 signaling pathway	0	0.4	0.7	0.7
LDHB		V
PDHA1		V
TFRC		V
EIF4E		V
LDHC			V
VEGFA				V
+ 04068: FoxO signaling pathway	0.3	2.2	0	0
IL7R	V
PRKAA2		V
NRAS		V
SKP2		V
CDK2		V
CCNB1		V
CCNB2		V
PLK4		V
PLK1		V
TNFSF10		V
SGK1		V
SMAD2		V
+ 04020: Calcium signaling pathway	2.8	0.5	0	0.9
PDE1A	V
SLC8A1	V
PDGFRA	V
PDGFRB	V
GNA14	V
MYLK	V
BDKRB1	V
ERBB3		V
ITPR1		V
ITPR2		V
PHKA1		V
CXCR4		V
CALM2		V
MCU		V
GNAL		V
SLC8A3				V
OXTR				V
+ 04070: Phosphatidylinositol signaling system	0	0.8	0	0
CALM2		V
ITPR1		V
ITPR2		V
PIK3C2B		V
DGKD		V
+ 04072: Phospholipase D signaling pathway	2.3	0.1	1.7	1.1
KIT	V
PDGFRA	V
PDGFRB	V
PLPP3	V
PDGFD	V
NRAS		V
LPAR3		V
PLA2G4A		V
DGKD		V
PLD1			V
FYN			V
FCER1G			V
RALB				V
SYK				V
+ 04071: Sphingolipid signaling pathway	0	0	2	0.6
NRAS		V
FCER1G			V
PLD1			V
FYN			V
TNF				V
+ 04024: cAMP signaling pathway	0.8	0.4	0.8	2.5
CREB3L1	V
GRIA1	V
GRIA3	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
CALM2		V
NPR1		V
PDE3A		V
PDE4D		V
CGA		V
CREB5			V
PLD1			V
FXYD2				V
FFAR2				V
OXTR				V
NFATC1				V
+ 04022: cGMP-PKG signaling pathway	3	1	2.2	2.2
PRKG1	V
PRKG2	V
KCNMA1	V
ADRA2A	V
CREB3L1	V
SLC8A1	V
MYLK	V
NPR1		V
ITPR1		V
ITPR2		V
RGS2		V	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
PDE3A		V
CALM2		V
GUCY1A1			V
KCNMB1			V
CREB5			V
NFATC1				V
SLC8A3				V
FXYD2				V
+ 04151: PI3K-Akt signaling pathway	3.4	1.3	0.4	0.8
KIT	V
PDGFRA	V
PDGFRB	V
FGF10	V
NTF3	V
PGF	V
PDGFD	V
TNC	V
THBS2	V
IL7R	V
PRLR	V
CREB3L1	V
EIF4E		V
ERBB3		V
LPAR3		V
MYC		V
EREG		V
AREG		V
NRAS		V
THEM4		V
HSP90AA1		V
PRKAA2		V
CDK2		V
CASP9		V
ITGA6		V
ITGA1		V
LAMA1		V
BRCA1		V
SGK1		V
CCNE1		V
NR4A1		V
GNG11			V
CREB5			V
VEGFA				V
SYK				V
TCL1A				V
+ 04152: AMPK signaling pathway	0.3	1.4	0.6	0.6
CREB3L1	V
PRKAA2		V
PFKFB2		V
SCD		V
PPARG		V
CCNA2		V
CCNA1		V
HMGCR		V
CD36		V
CREB5			V
PFKFB4				V
+ 04150: mTOR signaling pathway	0.2	1.3	1.1	1.1
WNT2	V		V
NRAS		V
SGK1		V
RRAGD		V
PRKAA2		V
EIF4E		V
SKP2		V
SEH1L		V
RICTOR		V
FZD3		V
LPIN1			V
TNF				V
WNT10A				V
+ 3.3 Signaling molecules and interaction	2.3	0.8	1.8	3.9
+ 04080: Neuroactive ligand-receptor interaction	1.7	0	0	0.9
PRLR	V
THRB	V
GRIA1	V
GRIA3	V
RXFP1	V
BDKRB1	V
ADRA2A	V
CGA		V
GABRA3		V
GLP2R		V
LPAR3		V
CHRNA5		V
GAL		V
KISS1R				V
OXTR				V
ADM				V
+ 04060: Cytokine-cytokine receptor interaction	1.6	0	1.5	3.4
IL1R1	V
TNFRSF19	V
EDA2R	V
PRLR	V
IL7R	V
IL13RA2	V
IL20RB		V
LIFR		V
IL18		V
IL1B		V
CXCR4		V
TNFSF10		V
BMP6		V
IL18RAP			V
IL18R1			V
IL1R2			V
CCL20			V
IL1A				V
CD27				V
LTB				V
LTA				V
TNF				V
IL17RB				V
CCL3L1				V
CCL22				V
+ 04061: Viral protein interaction with cytokine and cytokine receptor	0	0.5	2.2	2.8
CXCR4		V
IL18		V
IL20RB		V
TNFSF10		V
CCL20			V
IL18RAP			V
IL18R1			V
CCL3L1				V
CCL22				V
LTA				V
TNF				V
+ 04512: ECM-receptor interaction	1.2	1	0	0.8
TNC	V
THBS2	V
LAMA1		V
ITGA6		V
HMMR		V
CD36		V
ITGA1		V
CD44				V
+ 4. Cellular Processes	4.2	7.3	2.5	1.9
+ 4.1 Transport and catabolism	1.8	1.9	1.1	1.5
+ 04144: Endocytosis	1.1	0	0.7	0.2
VPS37C	V
PDGFRA	V
RAB11FIP2	V
EHD3	V
TFRC		V
CXCR4		V
ARRB1		V
SMAD2		V
SNX2		V
PLD1			V
CAV1			V
BIN1				V
+ 04145: Phagosome	1.7	1.9	0	1.1
C1R	V
ATP6V0A1	V
THBS2	V
CTSS	V
TUBA1B		V
TUBA3E		V
TUBA4A		V
TUBB4A		V
TUBB4B		V
TUBB		V
CD36		V
OLR1		V
TLR6		V
SEC61G		V
TFRC		V
HLA-DPB1				V
HLA-DQB1				V
+ 04142: Lysosome	2	1.1	1.3	2
ATP6V0A1	V
CTSK	V
CTSS	V
CD68	V
CTSH		V
CTSV		V
FUCA1		V
PPT1		V
LAMP3		V
LAPTM4B		V	V
SORT1		V
CTSC			V
CTSB				V
GM2A				V
ACP5				V
+ 04146: Peroxisome	0	1.5	0	0
ABCD3		V
HACL1		V
NUDT12		V
ACSL3		V
SLC27A2		V
IDH1		V
+ 04140: Autophagy - animal	0	0.5	0	0.6
NRAS		V
RRAGD		V
PRKAA2		V
ITPR1		V
VAMP8		V
CTSB				V
+ 04136: Autophagy - other	0	0	0	0
+ 04137: Mitophagy - animal	0	0.1	0.9	0
NRAS		V
CITED2			V
+ 4.2 Cell growth and death	1	10.2	1.4	1.6
+ 04110: Cell cycle	0	9	0	0
MCM2		V
MCM3		V
MCM4		V
MCM5		V
MCM6		V
MCM7		V
ORC1		V
ANAPC10		V
CDC23		V
CDK1		V
BUB1B		V
PLK1		V
MAD2L1		V
BUB1		V
SFN		V
CHEK1		V
PRKDC		V
SKP2		V
PTTG1		V
SMC1A		V
SMAD2		V
CDC7		V
CDC20		V
CDC25C		V
CDC45		V
CDC6		V
CCNB1		V
CCNB2		V
CCNA2		V
CCNA1		V
CDK2		V
CCNE1		V
TTK		V
RBL1		V
MYC		V
+ 04114: Oocyte meiosis	0.3	5.1	0	0
MOS	V
CDK1		V
MAD2L1		V
CCNB2		V
ANAPC10		V
CDC23		V
CDC20		V
PTTG1		V
CCNB1		V
FBXO5		V
CCNE1		V
CDC25C		V
CDK2		V
PLK1		V
AURKA		V
ITPR1		V
ITPR2		V
CALM2		V
SMC1A		V
SGO1		V
BUB1		V
+ 04210: Apoptosis	0.8	2.7	1.2	1.2
CTSK	V
CTSS	V
BIRC5		V
CASP9		V
TNFSF10		V
LMNB1		V
PARP1		V
CTSH		V
CTSV		V
ITPR1		V
ITPR2		V
TUBA1B		V
TUBA3E		V
TUBA4A		V
NRAS		V
PTPN13			V
CTSC			V
TNF				V
CTSB				V
+ 04215: Apoptosis - multiple species	0	0.8	0	1.3
CASP9		V
BIRC5		V
BIRC7				V
+ 04216: Ferroptosis	0.9	1.7	1.2	0
FTL	V
GCLC		V
TFRC		V
SAT1		V
ACSL3		V
SLC39A8			V
+ 04217: Necroptosis	0.6	2	1.6	1
STAT2	V
FTL	V
TNFSF10		V
HSP90AA1		V
IL1B		V
HIST1H2AE		V
HIST1H2AB		V
H2AFZ		V
HIST2H2AB		V
HIST1H2AL		V
HIST1H2AH		V
H2AFY		V
PARP1		V
PLA2G4A		V
STAT4			V
CASP1			V
H2AFY2			V
TNF				V
IL1A				V
+ 04115: p53 signaling pathway	0	4	0	0
CHEK1		V
RPRM		V
SFN		V
CDK2		V
CCNE1		V
RRM2		V
SERPINB5		V
CDK1		V
CASP9		V
PERP		V
CCNB1		V
CCNB2		V
+ 04218: Cellular senescence	0.2	3.4	0	1.1
KIR2DL2	V
MYC		V
NRAS		V
CDK2		V
CCNE1		V
RBL1		V
CCNA2		V
CCNA1		V
MYBL2		V
CHEK1		V
CDK1		V
CCNB1		V
CCNB2		V
CALM2		V
ITPR1		V
ITPR2		V
MCU		V
SMAD2		V
IL1A				V
NFATC1				V
+ 4.3 Cellular community - eukaryotes	2.9	2.1	2.4	0.6
+ 04510: Focal adhesion	2.7	0	0.8	0.3
MYLK	V
TNC	V
THBS2	V
PDGFRA	V
PDGFRB	V
PGF	V
PDGFD	V
ITGA6		V
ITGA1		V
DIAPH1		V
LAMA1		V
FYN			V
CAV1			V
VEGFA				V
+ 04520: Adherens junction	0	0.2	1.7	0
SMAD2		V
SSX2IP		V
CDH1			V
FYN			V
+ 04530: Tight junction	0	1	1	0.4
F11R		V
EZR		V
CLDN1		V	V
PRKAA2		V
TUBA1B		V
TUBA3E		V
TUBA4A		V
HSPA4		V
DLG2		V
CLDN16			V
RUNX1				V
+ 04540: Gap junction	3	2.8	0.7	0
PRKG1	V
PRKG2	V
PDGFRA	V
PDGFRB	V
PDGFD	V
CDK1		V
TUBB4A		V
TUBB4B		V
TUBB		V
TUBA1B		V
TUBA3E		V
TUBA4A		V
NRAS		V
ITPR1		V
ITPR2		V
GUCY1A1			V
+ 04550: Signaling pathways regulating pluripotency of stem cells	0.7	0.6	1.2	0.5
WNT2	V		V
MEIS1	V
FZD3		V
LIFR		V
SMAD2		V
NRAS		V
MYC		V
ID1		V
ID2			V
WNT10A				V
+ 4.5 Cell motility	2.6	0.4	0	0
+ 04810: Regulation of actin cytoskeleton	2.6	0.4	0	0
MYLK	V
MOS	V
BDKRB1	V
PDGFRA	V
PDGFRB	V
FGF10	V
PDGFD	V
PFN2		V
DIAPH1		V
EZR		V
DIAPH3		V
ITGA6		V
ITGA1		V
NRAS		V
CXCR4		V
+ 5. Organismal Systems	6.5	6	5.6	8.5
+ 5.1 Immune system	3.1	1.6	3.4	9.7
+ 04640: Hematopoietic cell lineage	2.3	1.9	0.7	3.5
KIT	V
IL1R1	V
ANPEP	V
IL7R	V
ITGA6		V
ITGA1		V
CD55		V
CD36		V
CR2		V
CD24		V
TFRC		V
IL1B		V
IL1R2			V
CD44				V
HLA-DPB1				V
HLA-DQB1				V
TNF				V
IL1A				V
+ 04610: Complement and coagulation cascades	4.2	1.1	0.8	0.8
BDKRB1	V
MASP1	V
C1R	V
C1S	V
SERPING1	V
CFH	V
CFB	V
TFPI		V
CD46		V
CD55		V
C4BPB		V
CR2		V
SERPINB2			V
F12				V
+ 04611: Platelet activation	2	0.3	1.9	0.6
APBB1IP	V
PRKG1	V
PRKG2	V
MYLK	V
ITPR1		V
ITPR2		V
PLA2G4A		V
VAMP8		V
GUCY1A1			V
FCER1G			V
FYN			V
SYK				V
+ 04620: Toll-like receptor signaling pathway	0.4	0.1	0	2.1
CTSK	V
IL1B		V
TLR6		V
IRF5				V
TNF				V
CCL3L1				V
+ 04621: NOD-like receptor signaling pathway	1	0.5	0.9	3.2
STAT2	V
GBP1	V
OAS2	V			V
IL1B		V
IL18		V
HSP90AA1		V
ITPR1		V
ITPR2		V
MCU		V
CARD6		V
CASP1			V
GBP4			V
AIM2				V
ANTXR2				V
CTSB				V
OAS1				V
TNF				V
+ 04622: RIG-I-like receptor signaling pathway	0	0.1	0	0.9
RNF125		V
TNF				V
+ 04623: Cytosolic DNA-sensing pathway	0	0.3	0.9	0.9
IL1B		V
IL18		V
CASP1			V
AIM2				V
+ 04625: C-type lectin receptor signaling pathway	0.4	1.1	1.4	2.8
STAT2	V
NRAS		V
IL1B		V
ITPR1		V
ITPR2		V
CALM2		V
PTGS2		V
FCER1G			V
CASP1			V
SYK				V
NFATC1				V
TNF				V
CCL22				V
+ 04650: Natural killer cell mediated cytotoxicity	0.3	0.1	1.2	1.9
KIR2DL2	V
TNFSF10		V
ULBP1		V
NRAS		V
FYN			V
FCER1G			V
NFATC1				V
TNF				V
SYK				V
+ 04612: Antigen processing and presentation	1.3	0.5	0	3.8
CTSS	V
KIR2DL2	V
IFI30		V
HSP90AA1		V
HSPA4		V
CD74				V
CTSB				V
HLA-DPB1				V
HLA-DQB1				V
TNF				V
+ 04660: T cell receptor signaling pathway	0	0	0.7	2.8
NRAS		V
FYN			V
TNF				V
NFKBIE				V
CARD11				V
NFATC1				V
+ 04658: Th1 and Th2 cell differentiation	0	0	0.7	2.9
STAT4			V
NFKBIE				V
NFATC1				V
HLA-DPB1				V
HLA-DQB1				V
+ 04659: Th17 cell differentiation	0.4	0.2	0.6	3.4
IL1R1	V
SMAD2		V
IL1B		V
HSP90AA1		V
RORA			V
NFKBIE				V
NFATC1				V
HLA-DPB1				V
HLA-DQB1				V
RUNX1				V
+ 04657: IL-17 signaling pathway	0.5	0.3	0.7	1.5
MMP3	V
HSP90AA1		V
PTGS2		V
IL1B		V
CCL20			V
IL17RB				V
TNF				V
+ 04662: B cell receptor signaling pathway	0.5	0.2	0	3.1
IFITM1	V
CR2		V
NRAS		V
NFKBIE				V
CARD11				V
NFATC1				V
SYK				V
+ 04664: Fc epsilon RI signaling pathway	0	0.3	1.8	2.6
NRAS		V
PLA2G4A		V
FCER1G			V
FYN			V
TNF				V
SYK				V
ALOX5				V
+ 04666: Fc gamma R-mediated phagocytosis	0.5	0	0.7	2.3
PLPP3	V
PLA2G4A		V
PLD1			V
HCK				V
SYK				V
BIN1				V
+ 04670: Leukocyte transendothelial migration	0	0.4	1.3	0
CLDN1		V	V
F11R		V
EZR		V
CXCR4		V
CLDN16			V
+ 04672: Intestinal immune network for IgA production	0	0.2	0	2.9
CXCR4		V
HLA-DPB1				V
HLA-DQB1				V
PIGR				V
+ 04062: Chemokine signaling pathway	0.2	0	0.9	1.5
STAT2	V
CXCR4		V
ARRB1		V
NRAS		V
CCL20			V
GNG11			V
CCL3L1				V
CCL22				V
HCK				V
+ 5.2 Endocrine system	3.1	5.7	2.9	3.3
+ 04911: Insulin secretion	1.2	0.7	1.6	2.3
CREB3L1	V
KCNMA1	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
SNAP25		V
CREB5			V
KCNMB1			V
FXYD2				V
KCNN3				V
+ 04910: Insulin signaling pathway	0	0.6	0.5	0
PRKAA2		V
PHKA1		V
CALM2		V
PRKAR2B		V
NRAS		V
EIF4E		V
PRKAR1A			V
+ 04922: Glucagon signaling pathway	0.4	1.8	1.4	0
CREB3L1	V
PDHA1		V
SIK1		V
PHKA1		V
CALM2		V
PRKAA2		V
ITPR1		V
ITPR2		V
LDHB		V
CREB5			V
LDHC			V
+ 04923: Regulation of lipolysis in adipocytes	1.5	0.8	0	0
PRKG1	V
PRKG2	V
NPR1		V
PTGS2		V
CGA		V
+ 04920: Adipocytokine signaling pathway	0	0.6	0	1.8
ACSL3		V
PRKAA2		V
CD36		V
NFKBIE				V
TNF				V
+ 03320: PPAR signaling pathway	0	3.2	0	0
CD36		V
SLC27A2		V
PPARG		V
ACADM		V
ACSL3		V
OLR1		V
HMGCS1		V
SCD		V
DBI		V
ME1		V
+ 04912: GnRH signaling pathway	0	1.2	0.7	0
CGA		V
PLA2G4A		V
ITPR1		V
ITPR2		V
CALM2		V
NRAS		V
PLD1			V
+ 04913: Ovarian steroidogenesis	0	1.4	0	1.1
CGA		V
PTGS2		V
PLA2G4A		V
BMP6		V
ALOX5				V
+ 04915: Estrogen signaling pathway	0.3	0.6	0.5	0
CREB3L1	V
NRAS		V
HSP90AA1		V
FKBP5		V
ITPR1		V
ITPR2		V
CALM2		V
CREB5			V
+ 04914: Progesterone-mediated oocyte maturation	0.5	4	0	0
MOS	V
CCNB1		V
CDK1		V
ANAPC10		V
CDC23		V
MAD2L1		V
BUB1		V
CDC25C		V
PLK1		V
CCNB2		V
HSP90AA1		V
CDK2		V
CCNA2		V
CCNA1		V
AURKA		V
+ 04917: Prolactin signaling pathway	0.6	0.2	0	0
PRLR	V
NRAS		V
CGA		V
+ 04921: Oxytocin signaling pathway	0.2	1.2	1.1	1.1
MYLK	V
ITPR1		V
ITPR2		V
CALM2		V
NRAS		V
PLA2G4A		V
PTGS2		V
NPR1		V
PRKAA2		V
RGS2		V	V
GUCY1A1			V
OXTR				V
NFATC1				V
+ 04926: Relaxin signaling pathway	0.8	0.1	1.2	0.6
RXFP1	V
CREB3L1	V
SMAD2		V
NRAS		V
ARRB1		V
GNG11			V
CREB5			V
VEGFA				V
+ 04918: Thyroid hormone synthesis	0.6	2.1	1.7	1.7
CREB3L1	V
CGA		V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
TTF2		V
ITPR1		V
ITPR2		V
CREB5			V
GPX7			V
FXYD2				V
+ 04919: Thyroid hormone signaling pathway	0.9	1.1	0	2.6
THRB	V
RCAN2	V
NRAS		V
PFKFB2		V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
CASP9		V
MYC		V
TBC1D4				V
FXYD2				V
SLC16A10				V
+ 04928: Parathyroid hormone synthesis, secretion and action	0.4	0.7	1.4	0
CREB3L1	V
ITPR1		V
ITPR2		V
PDE4D		V
ARRB1		V
NR4A2		V
PLD1			V
CREB5			V
+ 04916: Melanogenesis	1.6	0.2	0.7	0.7
KIT	V
CREB3L1	V
WNT2	V		V
CALM2		V
FZD3		V
NRAS		V
WNT10A				V
+ 04924: Renin secretion	2	1.4	0.9	0.9
PRKG2	V
KCNMA1	V
PDE1A	V
NPR1		V
ITPR1		V
ITPR2		V
PDE3A		V
CALM2		V
GUCY1A1			V
CTSB				V
+ 04614: Renin-angiotensin system	1.2	0	0	1.5
ANPEP	V
KLK1				V
+ 04925: Aldosterone synthesis and secretion	0.4	2.6	0.7	0.7
CREB3L1	V
ITPR1		V
ITPR2		V
CALM2		V
PRKD3		V
NR4A2		V
NR4A1		V
NPR1		V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
CREB5			V
+ 04927: Cortisol synthesis and secretion	1.4	1.4	0.9	0
CREB3L1	V
KCNA4	V
ITPR1		V
ITPR2		V
PDE8A		V
NCEH1		V
NR4A1		V
CREB5			V
+ 5.3 Circulatory system	1.5	1.1	1.8	2.7
+ 04260: Cardiac muscle contraction	0.5	1.4	0.8	2.3
SLC8A1	V
COX7A2		V
COX7B		V
UQCRQ		V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
TPM2			V
SLC8A3				V
FXYD2				V
+ 04261: Adrenergic signaling in cardiomyocytes	0.7	0.1	1.1	1.8
SLC8A1	V
CREB3L1	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
CALM2		V
TPM2			V
CREB5			V
SLC8A3				V
FXYD2				V
+ 04270: Vascular smooth muscle contraction	1.4	0.4	1.2	0.5
MYLK	V
KCNMA1	V
PRKG1	V
ITPR1		V
ITPR2		V
CALM2		V
PLA2G4A		V
NPR1		V
KCNMB1			V
GUCY1A1			V
ADM				V
+ 5.4 Digestive system	3.1	3.5	0.6	4.5
+ 04970: Salivary secretion	1.8	1.7	0.7	1.6
PRKG1	V
PRKG2	V
KCNMA1	V
SLC12A2		V
ITPR1		V
ITPR2		V
CALM2		V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
GUCY1A1			V
FXYD2				V
+ 04971: Gastric acid secretion	0.6	2	0	0.9
MYLK	V
ITPR1		V
ITPR2		V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
EZR		V
CALM2		V
+ 04972: Pancreatic secretion	0.4	1.2	0	1.5
KCNMA1	V
SLC12A2		V
ITPR1		V
ITPR2		V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
FXYD2				V
+ 04976: Bile secretion	0.6	1.7	0	1.7
AQP9	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
SLC51B		V
HMGCR		V
NCEH1		V
FXYD2				V
+ 04973: Carbohydrate digestion and absorption	0	1	0	2.1
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
FXYD2				V
+ 04974: Protein digestion and absorption	0.5	0.3	0	3.6
SLC8A1	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
FXYD2				V
SLC8A3				V
COL5A1				V
SLC16A10				V
+ 04975: Fat digestion and absorption	1.8	1.2	0	0
ABCA1	V
PLPP3	V
CD36		V
ACAT2		V
GOT2		V
+ 04979: Cholesterol metabolism	1.7	0.9	1.1	0
ABCA1	V
LRP1	V
NCEH1		V
CD36		V
SORT1		V
MYLIP			V
+ 04977: Vitamin digestion and absorption	0	0	0	0
+ 04978: Mineral absorption	2.3	0.8	0	2.8
SLC8A1	V
FTL	V
HEPH	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
SLC8A3				V
FXYD2				V
+ 5.5 Excretory system	1.2	3	0.5	3.8
+ 04962: Vasopressin-regulated water reabsorption	0.9	0.6	1.1	0
CREB3L1	V
AQP3		V
DYNLL1		V
CREB5			V
+ 04960: Aldosterone-regulated sodium reabsorption	0	2.3	0	2.2
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
SGK1		V
SFN		V
FXYD2				V
+ 04961: Endocrine and other factor-regulated calcium reabsorption	0.8	0.9	0	3.6
SLC8A1	V
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
SLC8A3				V
KLK1				V
FXYD2				V
+ 04964: Proximal tubule bicarbonate reclamation	0	3	0	2.6
ATP1A1		V
ATP1B1		V		V
ATP1B2		V
SLC38A3		V
MDH1		V
FXYD2				V
+ 04966: Collecting duct acid secretion	1.1	0	0	0
ATP6V0A1	V
+ 5.6 Nervous system	2.6	1.6	2.5	0.4
+ 04724: Glutamatergic synapse	0.9	0.9	1.3	0
GRIA1	V
GRIA3	V
SLC1A3		V
SLC38A3		V
SLC38A1		V
ITPR1		V
ITPR2		V
PLA2G4A		V
GNG11			V
PLD1			V
+ 04727: GABAergic synapse	0	0.3	0.7	0
GABRA3		V
SLC38A3		V
SLC38A1		V
GNG11			V
+ 04725: Cholinergic synapse	0.9	0.2	2	0
KCNQ5	V
CREB3L1	V
ITPR1		V
ITPR2		V
NRAS		V
GNG11			V
CREB5			V
FYN			V
+ 04728: Dopaminergic synapse	1.4	0.2	1.2	0
CREB3L1	V
GRIA1	V
GRIA3	V
GNAL		V
ITPR1		V
ITPR2		V
CALM2		V
GNG11			V
CREB5			V
+ 04726: Serotonergic synapse	0	0.6	0.6	0.6
ITPR1		V
ITPR2		V
PLA2G4A		V
PTGS2		V
NRAS		V
GNG11			V
ALOX5				V
+ 04720: Long-term potentiation	0.6	1	0	0
GRIA1	V
CALM2		V
NRAS		V
ITPR1		V
ITPR2		V
+ 04730: Long-term depression	2.8	1.1	0.9	0
GRIA1	V
GRIA3	V
PRKG1	V
PRKG2	V
PLA2G4A		V
NRAS		V
ITPR1		V
ITPR2		V
GUCY1A1			V
+ 04723: Retrograde endocannabinoid signaling	0.7	0.3	0.5	0
GRIA1	V
GRIA3	V
ITPR1		V
ITPR2		V
PTGS2		V
GABRA3		V
NDUFS1		V
GNG11			V
+ 04721: Synaptic vesicle cycle	0.6	0.2	0	0
ATP6V0A1	V
SNAP25		V
SLC1A3		V
+ 04722: Neurotrophin signaling pathway	0.3	0.1	0.6	0.6
NTF3	V
NRAS		V
SORT1		V
CALM2		V
BEX3			V
NFKBIE				V
+ 5.7 Sensory system	1.4	0.6	0.1	0
+ 04744: Phototransduction	0	0.4	0	0
CALM2		V
+ 04740: Olfactory transduction	1.3	0	0.3	0.1
OR1S1	V
OR4C12	V
OR9G1	V
PRKG1	V
PRKG2	V
PDE1A	V
SLC8A1	V
GNAL		V
CALM2		V
ARRB1		V
RGS2		V	V
NCALD			V
SLC8A3				V
+ 04742: Taste transduction	0.5	0	0	0
PDE1A	V
GABRA3		V
+ 04750: Inflammatory mediator regulation of TRP channels	1	0.8	0	0
BDKRB1	V
IL1R1	V
IL1B		V
PLA2G4A		V
ITPR1		V
ITPR2		V
CALM2		V
+ 5.8 Development and regeneration	2.4	0.1	2	2.5
+ 04360: Axon guidance	2	0.1	1.5	0.4
SLIT3	V
SLIT2	V
EFNB2	V
PLXNC1	V
SEMA3D	V
CXCR4		V
L1CAM		V
NRAS		V
FZD3		V
ROBO1			V
FYN			V
DPYSL2			V
EPHB1				V
+ 04380: Osteoclast differentiation	1.4	0	1.2	3.2
STAT2	V
IL1R1	V
CTSK	V
IL1B		V
PPARG		V
FYN			V
SIRPG			V
NFATC1				V
IL1A				V
SYK				V
ACP5				V
TNF				V
+ 5.9 Aging	0.3	0.7	1.2	0
+ 04211: Longevity regulating pathway	0.5	0.6	0.7	0
CREB3L1	V
NRAS		V
PRKAA2		V
EIF4E		V
PPARG		V
CREB5			V
+ 04213: Longevity regulating pathway - multiple species	0	0.3	0.9	0
NRAS		V
PRKAA2		V
FOXA2			V
+ 5.10 Environmental adaptation	1.7	1.2	2.6	0
+ 04710: Circadian rhythm	0	0.9	2.4	0
PRKAA2		V
BHLHE40		V
RORA			V
CRY1			V
+ 04713: Circadian entrainment	2.3	0.1	1.5	0
PRKG1	V
PRKG2	V
GRIA1	V
GRIA3	V
CALM2		V
ITPR1		V
GUCY1A1			V
GNG11			V
+ 04714: Thermogenesis	0.7	1	0.7	0
CREB3L1	V
PRKG1	V
PRKG2	V
PPARG		V
NPR1		V
NRAS		V
ACSL3		V
PRKAA2		V
COX20		V
COX7A2		V
COX7B		V
UQCRQ		V
NDUFS1		V
SDHC		V
ATP5MG		V
CREB5			V
SMARCA2			V
+ 6. Human Diseases	4.7	5.4	2.8	4.9
+ 6.1 Cancer: overview	4.2	4	2.1	3.7
+ 05200: Pathways in cancer	1.8	0.8	1.4	2.2
WNT2	V		V
PDGFRA	V
PDGFRB	V
KIT	V
RUNX1T1	V
PGF	V
FGF10	V
BDKRB1	V
IL7R	V
STAT2	V
CASP9		V
LAMA1		V
ITGA6		V
FZD3		V
HSP90AA1		V
NRAS		V
MYC		V
MSH2		V
SMAD2		V
MSH6		V
PPARG		V
JUP		V
CDK2		V
CCNE1		V
SKP2		V
CCNA1		V
BIRC5		V
PTGS2		V
LPAR3		V
CXCR4		V
NQO1		V
GSTM1		V
GSTM4		V
CALM2		V
CDH1			V
PLD1			V
GNG11			V
HEY2			V
STAT4			V
WNT10A				V
TFG				V
RALB				V
RUNX1				V
BIRC7				V
VEGFA				V
GSTM2				V
MGST1				V
+ 05202: Transcriptional misregulation in cancer	1.9	2.2	0.9	2.1
MMP3	V
RUNX1T1	V
MEIS1	V
GRIA3	V
FUT8	V
MYC		V
TSPAN7		V
MLF1		V
PPARG		V
CCNA1		V
JUP		V
DUSP6		V
HIST1H3A		V
HIST1H3C		V
HIST1H3I		V
HIST1H3G		V
HIST1H3H		V
HIST1H3B		V
HIST1H3F		V
ID2			V
IL1R2			V
RUNX1				V
LMO2				V
PBX3				V
LYL1				V
+ 05206: MicroRNAs in cancer	1.7	2.5	1.1	1.1
RECK	V
TNC	V
PDGFRA	V
PDGFRB	V
CDC25C		V
STMN1		V
CCNE1		V
EZR		V
SERPINB5		V
ERBB3		V
MYC		V
NRAS		V
EZH2		V
FZD3		V
IGF2BP1		V
BRCA1		V
PTGS2		V
SPRY2			V
VIM			V
VEGFA				V
CD44				V
+ 05205: Proteoglycans in cancer	0.1	0.7	0.8	2
WNT2	V		V
ITPR1		V
ITPR2		V
NRAS		V
DROSHA		V
SMAD2		V
ERBB3		V
MYC		V
FZD3		V
EZR		V
CAV1			V
CD44				V
VEGFA				V
TNF				V
WNT10A				V
+ 05204: Chemical carcinogenesis	2.5	0.4	0	1.6
ADH1A	V
ADH1B	V
AKR1C2	V
CYP2A6	V
GSTM1		V
GSTM4		V
PTGS2		V
GSTM2				V
MGST1				V
+ 05203: Viral carcinogenesis	0.1	3.5	0.3	0.3
CREB3L1	V
RBL1		V
CDK2		V
CCNA2		V
CCNA1		V
CCNE1		V
NRAS		V
SKP2		V
CDC20		V
CHEK1		V
CDK1		V
HIST1H2BF		V
HIST1H2BC		V
HIST1H2BB		V
HIST1H2BM		V
HIST1H4I		V
HIST1H4A		V
HIST1H4D		V
HIST1H4C		V
HIST1H4B		V
HIST1H4L		V
CREB5			V
SYK				V
+ 05230: Central carbon metabolism in cancer	2	1.4	0.9	0
KIT	V
PDGFRA	V
PDGFRB	V
MYC		V
PDHA1		V
LDHB		V
NRAS		V
IDH1		V
LDHC			V
+ 05231: Choline metabolism in cancer	2.3	0.5	0.7	0
PDGFRA	V
PDGFRB	V
PDGFD	V
PLPP3	V
NRAS		V
LYPLA1		V
PLA2G4A		V
DGKD		V
PLD1			V
+ 05235: PD-L1 expression and PD-1 checkpoint pathway in cancer	0	0	0	1.6
NRAS		V
NFKBIE				V
NFATC1				V
+ 6.2 Cancer: specific types	2.7	2.9	2.7	2.9
+ 05210: Colorectal cancer	0	2.5	0	0.8
CASP9		V
SMAD2		V
MSH2		V
BIRC5		V
MYC		V
MSH6		V
NRAS		V
EREG		V
AREG		V
RALB				V
+ 05212: Pancreatic cancer	0	0.2	0.8	1.7
CASP9		V
SMAD2		V
PLD1			V
RALB				V
VEGFA				V
+ 05225: Hepatocellular carcinoma	0.2	0.5	1	1.6
WNT2	V		V
NRAS		V
MYC		V
FZD3		V
SMAD2		V
NQO1		V
GSTM1		V
GSTM4		V
SMARCA2			V
WNT10A				V
GSTM2				V
MGST1				V
+ 05226: Gastric cancer	0.7	0.8	1.7	0.5
WNT2	V		V
FGF10	V
NRAS		V
MYC		V
FZD3		V
SMAD2		V
JUP		V
CCNE1		V
CDK2		V
CDH1			V
CDH17			V
WNT10A				V
+ 05214: Glioma	1.3	0.2	0	0
PDGFRA	V
PDGFRB	V
CALM2		V
NRAS		V
+ 05216: Thyroid cancer	0	1.2	1.2	1.2
NRAS		V
PPARG		V
MYC		V
CDH1			V
TFG				V
+ 05221: Acute myeloid leukemia	1.4	1.4	0	0.9
RUNX1T1	V
KIT	V
NRAS		V
MYC		V
JUP		V
CCNA1		V
DUSP6		V
RUNX1				V
+ 05220: Chronic myeloid leukemia	0	0.2	0	0.8
MYC		V
NRAS		V
RUNX1				V
+ 05217: Basal cell carcinoma	0.7	0.1	0.9	0.9
WNT2	V		V
FZD3		V
WNT10A				V
+ 05218: Melanoma	2.6	0.1	0.9	0
PDGFRA	V
PDGFRB	V
FGF10	V
PDGFD	V
NRAS		V
CDH1			V
+ 05211: Renal cell carcinoma	0	0.1	0	0.9
NRAS		V
VEGFA				V
+ 05219: Bladder cancer	0	0.6	1.2	1.2
MYC		V
NRAS		V
CDH1			V
VEGFA				V
+ 05215: Prostate cancer	2.8	0.8	1.5	0
PDGFRA	V
PDGFRB	V
CREB3L1	V
PDGFD	V
MMP3	V
CDK2		V
NRAS		V
CASP9		V
CCNE1		V
HSP90AA1		V
CREB5			V
IL1R2			V
+ 05213: Endometrial cancer	0	0.7	1	0
NRAS		V
CASP9		V
MYC		V
CDH1			V
+ 05224: Breast cancer	1.2	0.1	1.1	0.5
WNT2	V		V
KIT	V
FGF10	V
NRAS		V
MYC		V
FZD3		V
BRCA1		V
HEY2			V
WNT10A				V
+ 05222: Small cell lung cancer	0	2	0	0.7
CCNE1		V
CDK2		V
ITGA6		V
CASP9		V
MYC		V
LAMA1		V
PTGS2		V
SKP2		V
BIRC7				V
+ 05223: Non-small cell lung cancer	0	0.3	0	0
CASP9		V
NRAS		V
+ 6.12 Drug resistance: antineoplastic	1.3	2.5	0	1.9
+ 01521: EGFR tyrosine kinase inhibitor resistance	2.5	0.4	0	0.8
PDGFRA	V
PDGFRB	V
PDGFD	V
GAS6	V
ERBB3		V
NRAS		V
EIF4E		V
VEGFA				V
+ 01524: Platinum drug resistance	0	2.5	0	1.7
CASP9		V
BIRC5		V
GSTM1		V
GSTM4		V
TOP2A		V
BRCA1		V
MSH2		V
MSH6		V
GSTM2				V
MGST1				V
+ 01523: Antifolate resistance	0	2.1	0	1.3
GART		V
GGH		V
TYMS		V
IL1B		V
TNF				V
+ 01522: Endocrine resistance	0	0	0	0
NRAS		V

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META-Z-score:	download
Z-score:	download
Genes in pathway/subsystem/system:	download