Compound Information
Test on : GPCR
Compound Name : GSK2219385A
Inchikey : ZUXJDKZUOTZPMQ-UHFFFAOYSA-N
ChemSpider : 24692863
Pubchem CID : 25218573
ChEMBL : CHEMBL467581
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-5.28%) |
TYK2 | inactive (-1.64%) |
JAK2 | inactive (1.71%) |
JAK3 | inactive (-3.47%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (22.96%) |
FES | inactive (10.73%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (0.22%) |
ABL2 | inactive (-3.83%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-1.53%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.46%) |
BTK | inactive (-2.02%) |
TXK | inactive (-0.09%) |
TEC | inactive (1.07%) |
ITK | inactive (-1.94%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (1.53%) |
SRM | inactive (-1.33%) |
FRK | inactive (1.16%) |
BLK | inactive (-1.84%) |
LCK | inactive (-1.56%) |
HCK | inactive (4.78%) |
FGR | inactive (2%) |
FYN | inactive (-2.41%) |
SRC | inactive (5.62%) |
YES | inactive (-3.38%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-4.61%) |
EphA4 | inactive (-1.31%) |
EphA3 | inactive (-3.2%) |
EphB4 | inactive (-3.91%) |
EphB3 | inactive (-3.39%) |
EphB2 | inactive (4.5%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (45.84%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (1.76%) |
ZAP70 | inactive (-6.34%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | active (57.54%) |
ALK | active (69.91%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (51.24%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (107.4%) |
IGF1R | active (81.64%) |
IRR | inactive (17.14%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (0.56%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.08%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (1.31%) |
TRKB | inactive (-2.87%) |
TRKC | inactive (-1.19%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (8.44%) |
MET | inactive (1.68%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (3.71%) |
MER | inactive (1.94%) |
TYRO3 | inactive (-0.84%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (3.71%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-3.58%) |
FGFR2 | inactive (-2.01%) |
FGFR3 | inactive (-2.8%) |
FGFR4 | inactive (-2.22%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.09%) |
KDR | inactive (1.78%) |
FLT4 | inactive (-10.79%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (4.04%) |
KIT | inactive (-0.73%) |
FLT3 | inactive (2.03%) |
PDGFRa | inactive (7.22%) |
PDGFRb | inactive (2.38%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (2.24%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (0.64%) |
TNK1 | inactive (6.22%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (-1.47%) |
ErbB2 | inactive (-3.53%) |
ErbB4 | inactive (4.97%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.55%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (3.95%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (3.67%) |
MST1 | inactive (4.81%) |
MST2 | inactive (4.32%) |
MST4 | inactive (-1.63%) |
HGK | inactive (4.77%) |
MINK | inactive (1.74%) |
LOK | inactive (2.05%) |
PAK1 | inactive (0.54%) |
PAK3 | inactive (2.79%) |
PAK2 | inactive (0.77%) |
PAK5 | inactive (1.84%) |
PAK6 | inactive (-3.09%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.56%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (6%) |
CK1g2 | inactive (10.39%) |
CK1g1 | inactive (11.26%) |
CK1g3 | inactive (26.58%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.83%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (-0.55%) |
AurC | inactive (4.56%) |
AurA | inactive (-1.19%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.66%) |
NEK2 | inactive (3.64%) |
NEK9 | inactive (3.64%) |
NEK7 | inactive (2.22%) |
NEK6 | inactive (-1.46%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.23%) |
IKKe | inactive (0.91%) |
IKKb | inactive (-0.54%) |
IKKa | inactive (1.85%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (25.7%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-6.16%) |
GPRK6 | inactive (17.83%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.72%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.49%) |
MSK2 | inactive (2.79%) |
RSK1 | inactive (3.02%) |
RSK2 | inactive (1.43%) |
RSK4 | inactive (4.74%) |
RSK3 | inactive (2.69%) |
p70S6K | inactive (1.42%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-2.1%) |
AKT1 | inactive (-1.8%) |
AKT3 | inactive (-1.39%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (0.1%) |
SGK3 | inactive (0.78%) |
SGK2 | inactive (3.7%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.91%) |
PKCg | inactive (0.07%) |
PKCa | inactive (-2.59%) |
PKCt | inactive (-0.14%) |
PKCi | inactive (1.43%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.31%) |
PKG1 | inactive (3.77%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.64%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.48%) |
ROCK2 | inactive (-0.53%) |
MRCKb | inactive (1.21%) |
MRCKa | inactive (0.78%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (8.44%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-3.85%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (4.78%) |
CaMK1d | inactive (2.67%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (2.95%) |
PHKg2 | inactive (-0.16%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.38%) |
CaMK2a | inactive (4.38%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-1.14%) |
MAPKAPK2 | inactive (0.04%) |
MAPKAPK3 | inactive (0.17%) |
MNK2 | inactive (-0.74%) |
MNK1 | inactive (1.72%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.06%) |
PKD1 | inactive (-0.45%) |
PKD2 | inactive (-0.62%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.75%) |
MARK3 | inactive (4.11%) |
MARK1 | inactive (1.97%) |
QIK | inactive (2.04%) |
SIK | inactive (5.4%) |
NuaK1 | inactive (4.1%) |
BRSK1 | inactive (-0.02%) |
BRSK2 | inactive (0.83%) |
MELK | inactive (5.45%) |
CHK1 | inactive (-0.94%) |
PASK | inactive (-1.13%) |
AMPKa1 | inactive (0.94%) |
AMPKa2 | inactive (3.07%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (4.87%) |
TSSK1 | inactive (16.44%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.79%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-2.78%) |
PIM3 | inactive (0.76%) |
PIM1 | inactive (3.33%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (2.97%) |
p38a | inactive (3.91%) |
p38b | inactive (0.98%) |
p38d | inactive (1.9%) |
Erk2 | inactive (3.4%) |
Erk1 | inactive (2.25%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (-1.13%) |
GSK3B | inactive (-3.33%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.38%) |
MSSK1 | inactive (1.28%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-1.03%) |
CLK2 | inactive (12.55%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (2.02%) |
HIPK4 | inactive (4.88%) |
DYRK1B | inactive (13.05%) |
DYRK1A | inactive (15.2%) |
DYRK2 | inactive (1.64%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (4.3%) |