Compound Information
Test on : RBC, Millipore
Compound Name
RBC : 856436-16-3
Millipore : JAK3 Inhibitor VI
Inchikey
Same : ZUDPNBZMAJGYTE-N
RBC : ZUDPNBZMAJGYTE-UHFFFAOYSA-N
Millipore : ZUDPNBZMAJGYTE-HYMQDMCPSA-N
ChemSpider
RBC : 21465183
Millipore : 21395909
Pubchem CID
RBC : 24906278
Millipore : 16760524
ChEMBL
RBC : -
Millipore : CHEMBL2397013
RBC | Millipore |
| |
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PDK1 | active (46.88%) | active (6%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AKT1 | inactive (100.86%) | inactive (96%) |
AKT2 | inactive (101.67%) | inactive (131%) |
AKT3 | inactive (91.16%) | inactive (68%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DMPK1 | inactive (106.88%) | inactive (125%) |
MRCKa | inactive (98.36%) | inactive (95%) |
MRCKb | inactive (90.23%) | inactive (66%) |
ROCK1 | active (38.06%) | inactive (86%) |
ROCK2 | active (17.29%) | active (10%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BARK1 | inactive (100.77%) | - |
BARK2 | inactive (95.43%) | - |
GPRK4 | inactive (86.4%) | - |
GPRK5 | inactive (82.99%) | inactive (76%) |
GPRK6 | inactive (76.86%) | inactive (81%) |
GPRK7 | inactive (67.56%) | active (41%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MSK1 | inactive (54.21%) | inactive (60%) |
MSK2 | active (48.98%) | active (23%) |
p70S6K | active (26.65%) | active (8%) |
p70S6Kb | inactive (92.53%) | - |
RSK2 | active (24.85%) | active (11%) |
RSK4 | active (10.77%) | active (10%) |
RSK1 | active (0.91%) | active (3%) |
RSK3 | active (7.21%) | active (10%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKACg | inactive (102.38%) | - |
PRKX | active (43.52%) | active (37%) |
PKACa | inactive (83.22%) | inactive (61%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKCa | inactive (86.72%) | inactive (87%) |
PKCd | active (36.05%) | inactive (54%) |
PKCe | inactive (66.99%) | inactive (69%) |
PKCh | inactive (83.9%) | inactive (92%) |
PKCg | inactive (78.08%) | inactive (67%) |
PKCi | inactive (92.03%) | inactive (88%) |
PKCt | inactive (114.56%) | active (28%) |
PKCz | inactive (101.52%) | inactive (91%) |
PKCb | inactive (72.88%) | - |
AGC - PKG
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKG2 | active (2.21%) | - |
PKG1 | inactive (60.57%) | - |
AGC - PKN
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKN1 | active (14.38%) | - |
PKN2 | inactive (70.87%) | active (15%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SGK1 | active (25.95%) | active (25%) |
SGK2 | active (28.13%) | active (12%) |
SGK3 | inactive (63.64%) | inactive (58%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NDR1 | inactive (60%) | - |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ABL1 | inactive (61.97%) | active (39%) |
ABL2 | inactive (67.23%) | inactive (59%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ACK | inactive (79.44%) | inactive (57%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ALK | inactive (76.02%) | inactive (63%) |
LTK | inactive (67.57%) | - |
TK - Axl
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AXL | inactive (80.75%) | active (8%) |
MER | inactive (66.4%) | active (8%) |
TYRO3 | inactive (71.66%) | inactive (55%) |
TK - Src
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BLK | inactive (53.63%) | active (12%) |
BRK | inactive (86.3%) | inactive (85%) |
SRC | inactive (58.86%) | inactive (68%) |
FGR | active (34.37%) | active (11%) |
FRK | inactive (95.15%) | inactive (69%) |
FYN | active (32.67%) | active (37%) |
HCK | inactive (65.04%) | active (40%) |
LCK | inactive (70.65%) | active (38%) |
SRM | inactive (104.7%) | - |
YES | active (35.03%) | active (14%) |
LYN | active (30.32%) | active (10%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BMX | inactive (89.34%) | active (50%) |
BTK | inactive (88.69%) | inactive (90%) |
ITK | inactive (55.5%) | active (46%) |
TEC | inactive (105.06%) | - |
TXK | inactive (75.73%) | inactive (53%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
KIT | inactive (86.09%) | inactive (104%) |
FLT3 | active (1.61%) | active (0%) |
FMS | inactive (92.47%) | active (42%) |
PDGFRb | active (32.26%) | inactive (71%) |
PDGFRa | inactive (56.02%) | inactive (93%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CSK | inactive (80.5%) | inactive (108%) |
CTK | inactive (96.56%) | - |
TK - DDR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DDR2 | inactive (98.46%) | inactive (110%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
EGFR | inactive (104.4%) | inactive (115%) |
ErbB2 | inactive (102.54%) | - |
ErbB4 | inactive (93.04%) | inactive (100%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
EphA1 | inactive (98.15%) | inactive (87%) |
EphA2 | inactive (103.76%) | inactive (104%) |
EphA3 | inactive (96.79%) | inactive (105%) |
EphA4 | inactive (98.42%) | inactive (112%) |
EphA5 | inactive (101.82%) | inactive (102%) |
EphA6 | inactive (77.05%) | - |
EphA7 | inactive (95.61%) | inactive (92%) |
EphA8 | inactive (99.43%) | inactive (92%) |
EphB1 | inactive (91.21%) | inactive (81%) |
EphB2 | inactive (100.33%) | inactive (112%) |
EphB3 | inactive (90.28%) | inactive (101%) |
EphB4 | inactive (99.05%) | inactive (96%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FAK | inactive (93.79%) | inactive (93%) |
PYK2 | inactive (89.96%) | inactive (84%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FER | inactive (77.12%) | inactive (97%) |
FES | inactive (87.75%) | inactive (93%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FGFR1 | inactive (69.53%) | active (28%) |
FGFR2 | inactive (70.91%) | active (49%) |
FGFR3 | inactive (64.61%) | active (46%) |
FGFR4 | inactive (98.9%) | inactive (122%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FLT1 | active (30.09%) | active (2%) |
FLT4 | active (5.12%) | active (2%) |
KDR | active (24.71%) | active (5%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IGF1R | inactive (103.54%) | inactive (143%) |
IRR | inactive (89.09%) | inactive (122%) |
INSR | inactive (101.5%) | inactive (71%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
JAK1 | inactive (60.32%) | - |
JAK2 | inactive (58.01%) | active (40%) |
JAK3 | active (4.79%) | active (6%) |
TYK2 | active (20.37%) | - |
TK - Musk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MUSK | active (6.09%) | active (25%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RET | active (18.04%) | active (13%) |
TK - Met
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RON | inactive (80.01%) | inactive (67%) |
MET | inactive (103.31%) | inactive (62%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ROS | inactive (86.24%) | inactive (85%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SYK | inactive (72.45%) | inactive (90%) |
ZAP70 | inactive (96.5%) | inactive (98%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TIE2 | inactive (94.64%) | active (34%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TRKA | active (8.96%) | active (1%) |
TRKB | active (7.65%) | active (6%) |
TRKC | active (2.64%) | - |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ALK1 | inactive (101.96%) | - |
ALK2 | inactive (108.15%) | - |
ALK4 | inactive (137.56%) | inactive (64%) |
TGFbR1 | inactive (107%) | inactive (58%) |
TGFbR2 | inactive (86.48%) | - |
TKL - RAF
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ARAF | inactive (141.73%) | - |
BRAF | inactive (112.04%) | - |
RAF1 | inactive (120.91%) | inactive (69%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IRAK1 | active (14.45%) | active (1%) |
IRAK4 | active (8.32%) | active (3%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
LIMK1 | inactive (95.19%) | inactive (83%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
LRRK2 | active (6.23%) | - |
TKL - MLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MLK1 | active (18.59%) | active (6%) |
MLK2 | active (39.81%) | - |
MLK3 | active (8.73%) | - |
TAK1 | active (9.69%) | active (10%) |
ZAK | inactive (57.15%) | - |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RIPK2 | inactive (52.87%) | active (30%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NuaK1 | active (5.27%) | active (10%) |
BRSK1 | active (19.7%) | active (1%) |
BRSK2 | active (15.93%) | active (10%) |
CHK1 | active (5.97%) | active (10%) |
LKB1 | active (34.81%) | inactive (90%) |
MARK1 | active (3.26%) | active (1%) |
MARK3 | active (3.87%) | - |
MARK4 | active (1.56%) | - |
MELK | active (4.63%) | active (4%) |
PASK | active (32.03%) | active (40%) |
QIK | inactive (66.62%) | - |
NuaK2 | active (43.72%) | - |
MARK2 | active (3.25%) | active (1%) |
AMPKa1 | - | active (6%) |
AMPKa2 | - | active (5%) |
SIK | - | active (36%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMK1a | inactive (94.66%) | inactive (81%) |
CaMK1b | inactive (98.89%) | - |
CaMK1d | inactive (83.47%) | inactive (52%) |
CaMK1g | inactive (94.81%) | - |
CaMK4 | inactive (93.43%) | inactive (103%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMK2a | active (16.79%) | - |
CaMK2b | active (29.45%) | active (13%) |
CaMK2d | active (32.13%) | active (8%) |
CaMK2g | inactive (78.48%) | active (12%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CHK2 | active (26.3%) | active (24%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DAPK1 | inactive (82.27%) | inactive (94%) |
DAPK2 | inactive (113.29%) | inactive (85%) |
DRAK1 | active (5.2%) | active (1%) |
DAPK3 | inactive (99.6%) | inactive (91%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DCLK2 | inactive (87.85%) | inactive (71%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAPKAPK2 | inactive (100.35%) | inactive (83%) |
MAPKAPK3 | inactive (100.86%) | inactive (116%) |
MAPKAPK5 | inactive (83.69%) | active (43%) |
MNK1 | inactive (79.5%) | - |
MNK2 | inactive (72.99%) | active (47%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
smMLCK | active (41.73%) | active (23%) |
skMLCK | active (5.85%) | - |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PHKg1 | active (9.56%) | - |
PHKg2 | active (46.97%) | active (22%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PIM1 | active (41.78%) | active (35%) |
PIM2 | inactive (87.39%) | active (13%) |
PIM3 | active (7.61%) | inactive (63%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKD1 | active (2.07%) | active (6%) |
PKD3 | active (1.85%) | - |
PKD2 | active (2.2%) | active (25%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TSSK1 | active (39.61%) | active (21%) |
TSSK2 | inactive (97.49%) | inactive (88%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
STK33 | active (14.96%) | active (24%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAP3K5 | inactive (91.23%) | inactive (61%) |
MAP3K2 | inactive (58.41%) | - |
MAP3K3 | inactive (62.96%) | - |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
COT | inactive (104.45%) | - |
NIK | inactive (123.51%) | - |
STE - STE20
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
GCK | active (4.84%) | active (3%) |
HGK | active (0.63%) | - |
KHS1 | active (6.03%) | - |
LOK | active (15.32%) | active (8%) |
MINK | active (1.72%) | active (6%) |
MST1 | active (4.24%) | active (2%) |
MST2 | active (2.72%) | active (5%) |
MST3 | active (23.5%) | active (12%) |
MST4 | active (27.29%) | - |
OSR1 | inactive (99.69%) | - |
PAK1 | inactive (78.68%) | - |
PAK2 | inactive (86.3%) | inactive (86%) |
PAK3 | inactive (82.94%) | inactive (55%) |
PAK4 | inactive (90.83%) | inactive (68%) |
PAK5 | inactive (97.82%) | inactive (66%) |
PAK6 | inactive (92.63%) | inactive (64%) |
SLK | inactive (51.97%) | - |
YSK1 | active (47.19%) | - |
STLK3 | inactive (95.89%) | - |
TAO1 | active (22.59%) | active (8%) |
TAO2 | inactive (72.41%) | active (50%) |
TAO3 | active (21.13%) | active (13%) |
MYO3B | inactive (50.89%) | - |
STE - STE7
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAP2K1 | inactive (81.26%) | active (9%) |
MAP2K2 | inactive (77.68%) | - |
MAP2K6 | inactive (78.81%) | active (22%) |
MAP2K7 | - | inactive (70%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AurA | active (39.22%) | active (4%) |
AurB | active (8.5%) | active (4%) |
AurC | active (48.54%) | inactive (53%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMKK1 | active (23.77%) | - |
CaMKK2 | active (10.11%) | - |
Other - Haspin
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Haspin | active (22.54%) | active (9%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IKKa | inactive (60.34%) | active (5%) |
IKKb | inactive (69.23%) | inactive (51%) |
IKKe | active (14.86%) | - |
TBK1 | active (4.45%) | active (1%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NEK1 | inactive (71.97%) | - |
NEK11 | inactive (107.55%) | active (40%) |
NEK2 | inactive (82.59%) | inactive (65%) |
NEK4 | active (26.12%) | - |
NEK6 | inactive (100.74%) | inactive (90%) |
NEK7 | inactive (91.25%) | inactive (101%) |
NEK9 | inactive (66.26%) | - |
NEK3 | inactive (100.81%) | inactive (98%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PBK | inactive (91.26%) | - |
Other - PLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PLK1 | inactive (97.35%) | inactive (77%) |
PLK2 | inactive (92.87%) | inactive (87%) |
PLK3 | inactive (99.11%) | inactive (92%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SgK496 | inactive (84.85%) | - |
Other - NAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MPSK1 | active (44.28%) | - |
Other - TTK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TTK | inactive (54.4%) | - |
Other - ULK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ULK1 | active (11.54%) | - |
ULK2 | active (48.11%) | active (46%) |
ULK3 | active (41.69%) | active (37%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Wee1 | inactive (69.43%) | - |
Other - WNK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Wnk2 | inactive (107.41%) | inactive (80%) |
Wnk3 | inactive (82.63%) | inactive (99%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TLK2 | inactive (50.83%) | active (38%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
CK1 | 7 | 6 | 4 |
VRK | 3 | 1 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CK1d | inactive (92.57%) | inactive (73%) |
CK1g1 | inactive (104.07%) | inactive (90%) |
CK1g2 | inactive (95.46%) | inactive (79%) |
CK1g3 | inactive (87.88%) | inactive (92%) |
CK1a | inactive (87.71%) | - |
CK1e | inactive (72.9%) | - |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
VRK1 | inactive (86.78%) | - |
VRK2 | - | inactive (88%) |
CMGC
CMGC
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
CK2 | 3 | 2 | 2 |
CLK | 4 | 4 | 2 |
DYRK | 10 | 9 | 4 |
MAPK | 14 | 10 | 10 |
GSK | 2 | 2 | 2 |
SRPK | 3 | 3 | 3 |
CMGC - CK2
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CK2a1 | inactive (73.98%) | inactive (69%) |
CK2a2 | - | inactive (105%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CLK1 | active (4.07%) | - |
CLK2 | active (0.33%) | active (1%) |
CLK3 | inactive (63.97%) | active (7%) |
CLK4 | active (8.92%) | - |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DYRK1A | active (5.06%) | - |
DYRK1B | active (5%) | - |
DYRK2 | active (3.11%) | active (-5%) |
DYRK3 | active (30.4%) | - |
DYRK4 | inactive (93.42%) | - |
HIPK1 | inactive (106.64%) | active (45%) |
HIPK2 | inactive (60.3%) | active (8%) |
HIPK3 | inactive (66.35%) | active (10%) |
HIPK4 | inactive (58.66%) | - |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Erk1 | inactive (71.81%) | active (25%) |
Erk2 | inactive (80.67%) | inactive (65%) |
JNK3 | inactive (111.29%) | active (18%) |
NLK | inactive (94.64%) | inactive (75%) |
p38a | inactive (97.58%) | inactive (87%) |
p38b | inactive (104.49%) | inactive (83%) |
p38d | inactive (98.23%) | inactive (73%) |
p38g | inactive (98.96%) | inactive (83%) |
JNK1 | inactive (86.78%) | inactive (65%) |
JNK2 | inactive (60.77%) | inactive (80%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
GSK3A | active (11.3%) | active (12%) |
GSK3B | active (16.72%) | active (14%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MSSK1 | inactive (94.09%) | inactive (91%) |
SRPK1 | inactive (94.33%) | inactive (98%) |
SRPK2 | inactive (97.3%) | inactive (96%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
PDHK | 5 | 1 | - |
Alpha | 6 | - | 1 |
PIKK | 6 | - | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PDHK1 | active (46.88%) | - |
Atypical - Alpha
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
eEF2K | - | inactive (83%) |
Atypical - PIKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FRAP | - | inactive (107%) |