Compound Information
Test on : GPCR
Compound Name : GW700494A
Inchikey : ZTYWWSYUDYNRMS-UHFFFAOYSA-N
ChemSpider : 28484247
Pubchem CID : 57391092
ChEMBL : CHEMBL1909372
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (1.78%) |
TYK2 | inactive (0.88%) |
JAK2 | inactive (6.4%) |
JAK3 | inactive (0.29%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.71%) |
FES | inactive (1.53%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (13.62%) |
ABL2 | inactive (15.44%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-3.31%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.63%) |
BTK | inactive (1.43%) |
TXK | inactive (5.01%) |
TEC | inactive (5.07%) |
ITK | inactive (-1.94%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (1.35%) |
SRM | inactive (0.43%) |
FRK | inactive (5.78%) |
BLK | inactive (-2.3%) |
LCK | inactive (7.95%) |
HCK | inactive (9.14%) |
FGR | inactive (8.15%) |
FYN | inactive (-1.88%) |
SRC | inactive (3.58%) |
YES | inactive (-1.74%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (2.37%) |
EphA4 | inactive (25.93%) |
EphA3 | inactive (-0.47%) |
EphB4 | inactive (16.37%) |
EphB3 | inactive (-6.41%) |
EphB2 | active (58.78%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (7.87%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.86%) |
ZAP70 | inactive (2.82%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (-0.03%) |
ALK | inactive (0.57%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.76%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (-17.58%) |
IGF1R | inactive (-7.78%) |
IRR | inactive (0.55%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (83.59%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (59.24%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (34.02%) |
TRKB | inactive (10.58%) |
TRKC | inactive (17.43%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (5.53%) |
MET | inactive (8.95%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (27.52%) |
MER | inactive (6.67%) |
TYRO3 | inactive (19.08%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (86.23%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (0.63%) |
FGFR2 | inactive (1.51%) |
FGFR3 | inactive (-0.55%) |
FGFR4 | inactive (-0.18%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (40.7%) |
KDR | active (71.93%) |
FLT4 | inactive (-0.49%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (17.32%) |
KIT | active (91.86%) |
FLT3 | active (61.16%) |
PDGFRa | active (76.41%) |
PDGFRb | inactive (25.77%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | active (53.81%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (5.75%) |
TNK1 | inactive (4.81%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (0.24%) |
ErbB2 | inactive (-2.07%) |
ErbB4 | inactive (2.56%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.11%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (13.69%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (8.26%) |
MST1 | inactive (3.57%) |
MST2 | inactive (3.55%) |
MST4 | inactive (0.74%) |
HGK | inactive (2.12%) |
MINK | inactive (1.26%) |
LOK | active (53.03%) |
PAK1 | inactive (2.58%) |
PAK3 | inactive (2.65%) |
PAK2 | inactive (1.06%) |
PAK5 | inactive (8.65%) |
PAK6 | inactive (-3.76%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (1.94%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (0.56%) |
CK1g2 | inactive (-2.41%) |
CK1g1 | inactive (-3.19%) |
CK1g3 | inactive (-4.66%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.98%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (4.51%) |
AurC | inactive (23.68%) |
AurA | inactive (-0.34%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.88%) |
NEK2 | inactive (0.01%) |
NEK9 | inactive (-1.83%) |
NEK7 | inactive (0.94%) |
NEK6 | inactive (-2.03%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.78%) |
IKKe | inactive (-0.63%) |
IKKb | inactive (-0.85%) |
IKKa | inactive (-6.02%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (20.82%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-3.95%) |
GPRK6 | inactive (-5.54%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.39%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-0.08%) |
MSK2 | inactive (2.99%) |
RSK1 | inactive (-1.68%) |
RSK2 | inactive (-0.48%) |
RSK4 | inactive (-0.1%) |
RSK3 | inactive (2.27%) |
p70S6K | inactive (4.19%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.85%) |
AKT1 | inactive (-3.59%) |
AKT3 | inactive (-2.98%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (5.49%) |
SGK3 | inactive (0.75%) |
SGK2 | inactive (1.09%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.68%) |
PKCg | inactive (2.83%) |
PKCa | inactive (-1.52%) |
PKCt | inactive (-0.32%) |
PKCi | inactive (1.05%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.7%) |
PKG1 | inactive (3.23%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.08%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (3.23%) |
ROCK2 | inactive (0.51%) |
MRCKb | inactive (2.84%) |
MRCKa | inactive (-0.74%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.77%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.8%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (4.86%) |
CaMK1d | inactive (4.38%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (0.68%) |
PHKg2 | inactive (-0.8%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (6.84%) |
CaMK2a | inactive (7.84%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-1.41%) |
MAPKAPK2 | inactive (-0.49%) |
MAPKAPK3 | inactive (18.3%) |
MNK2 | inactive (9.51%) |
MNK1 | inactive (15.5%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (-1.97%) |
PKD1 | inactive (-1.77%) |
PKD2 | inactive (-0.73%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.34%) |
MARK3 | inactive (0.11%) |
MARK1 | inactive (0.66%) |
QIK | inactive (0.76%) |
SIK | inactive (3.99%) |
NuaK1 | inactive (4.39%) |
BRSK1 | inactive (2.58%) |
BRSK2 | inactive (0.19%) |
MELK | inactive (-0.26%) |
CHK1 | inactive (0.8%) |
PASK | inactive (-1.18%) |
AMPKa1 | inactive (-0.25%) |
AMPKa2 | inactive (3.1%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.46%) |
TSSK1 | inactive (-0.16%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-0.71%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-1.74%) |
PIM3 | inactive (-0.28%) |
PIM1 | inactive (0.87%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.71%) |
p38a | active (51.84%) |
p38b | inactive (22.06%) |
p38d | inactive (1.31%) |
Erk2 | inactive (0.12%) |
Erk1 | inactive (0.83%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (0.59%) |
GSK3B | inactive (-1.5%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.44%) |
MSSK1 | inactive (4.1%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-3.62%) |
CLK2 | inactive (1.41%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (-3.43%) |
HIPK4 | inactive (40.61%) |
DYRK1B | inactive (-2.58%) |
DYRK1A | inactive (-2.54%) |
DYRK2 | inactive (-0.19%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (-5.31%) |