Compound Information
Test on : RBC
Compound Name : Mubritinib
Inchikey : ZTFBIUXIQYRUNT-MDWZMJQESA-N
ChemSpider : 4948554
Pubchem CID : 6444692
ChEMBL : CHEMBL1614707
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (103.58%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (93.16%) |
AKT2 | inactive (99.87%) |
AKT3 | inactive (96.28%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (100.64%) |
MRCKa | inactive (102.8%) |
MRCKb | inactive (100.19%) |
ROCK1 | inactive (100.12%) |
ROCK2 | inactive (99.7%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (112.97%) |
BARK2 | inactive (103.71%) |
GPRK4 | inactive (101.86%) |
GPRK5 | inactive (109.25%) |
GPRK6 | inactive (103.77%) |
GPRK7 | inactive (97.82%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (111.04%) |
MSK2 | inactive (105.36%) |
p70S6K | inactive (104.84%) |
p70S6Kb | inactive (103.46%) |
RSK2 | inactive (96.8%) |
RSK4 | inactive (100.3%) |
RSK1 | inactive (97.9%) |
RSK3 | inactive (96.81%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | inactive (105.07%) |
PRKX | inactive (95.32%) |
PKACa | inactive (100.72%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (110.57%) |
PKCd | inactive (99.65%) |
PKCe | inactive (101.47%) |
PKCh | inactive (87.64%) |
PKCg | inactive (95.21%) |
PKCi | inactive (92.56%) |
PKCt | inactive (99.92%) |
PKCz | inactive (101.43%) |
PKCb | inactive (93.08%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (89.85%) |
PKG1 | inactive (75.86%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (97.03%) |
PKN2 | inactive (106.71%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (101.65%) |
SGK2 | inactive (103.23%) |
SGK3 | inactive (89.24%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | inactive (101.63%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (99.55%) |
ABL2 | inactive (98.21%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (81.81%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (108.23%) |
LTK | inactive (103.54%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (100.51%) |
MER | inactive (97.91%) |
TYRO3 | inactive (102.82%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (102%) |
BRK | inactive (97.77%) |
SRC | inactive (92.48%) |
FGR | inactive (92.57%) |
FRK | inactive (98.97%) |
FYN | inactive (97.04%) |
HCK | inactive (93.87%) |
LCK | inactive (92.06%) |
SRM | inactive (93.47%) |
YES | inactive (84.97%) |
LYN | inactive (95.78%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (98.98%) |
BTK | inactive (98.19%) |
ITK | inactive (101.5%) |
TEC | inactive (86.35%) |
TXK | inactive (100.65%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (98.81%) |
FLT3 | inactive (87.8%) |
FMS | inactive (103.02%) |
PDGFRb | inactive (98.07%) |
PDGFRa | inactive (103.71%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (106.36%) |
CTK | inactive (94.96%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (100.68%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (97.67%) |
ErbB2 | inactive (102.15%) |
ErbB4 | inactive (99.57%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (97.23%) |
EphA2 | inactive (102.02%) |
EphA3 | inactive (92.7%) |
EphA4 | inactive (98.81%) |
EphA5 | inactive (99.91%) |
EphA6 | inactive (99.34%) |
EphA7 | inactive (95.23%) |
EphA8 | inactive (104.43%) |
EphB1 | inactive (99.41%) |
EphB2 | inactive (98.33%) |
EphB3 | inactive (94.92%) |
EphB4 | inactive (92.25%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (100.66%) |
PYK2 | inactive (102.77%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (102.44%) |
FES | inactive (102%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (101.49%) |
FGFR2 | inactive (96.66%) |
FGFR3 | inactive (88.39%) |
FGFR4 | inactive (88.35%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (95.48%) |
FLT4 | inactive (97.95%) |
KDR | inactive (105.76%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (100.68%) |
IRR | inactive (100.6%) |
INSR | inactive (99.57%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (102.61%) |
JAK2 | inactive (98.91%) |
JAK3 | inactive (92.99%) |
TYK2 | inactive (99.11%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (104.27%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (101%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (103.69%) |
MET | inactive (95.05%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (93.26%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (97.37%) |
ZAP70 | inactive (115.41%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (95.81%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (103.13%) |
TRKB | inactive (101.86%) |
TRKC | inactive (98.85%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (103.04%) |
ALK2 | inactive (100.89%) |
ALK4 | inactive (92.79%) |
TGFbR1 | inactive (98.8%) |
TGFbR2 | inactive (103.22%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (101.82%) |
BRAF | inactive (94.27%) |
RAF1 | inactive (97.12%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (99.48%) |
IRAK4 | inactive (97.74%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (99.22%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (94.77%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (104.87%) |
MLK2 | inactive (98.85%) |
MLK3 | inactive (99.14%) |
TAK1 | inactive (88.68%) |
ZAK | inactive (98.54%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (109.08%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (102.73%) |
BRSK1 | inactive (102.52%) |
BRSK2 | inactive (99.59%) |
CHK1 | inactive (107.82%) |
LKB1 | inactive (104.3%) |
MARK1 | inactive (101.69%) |
MARK3 | inactive (96.63%) |
MARK4 | inactive (97.92%) |
MELK | inactive (85.36%) |
PASK | inactive (104.23%) |
QIK | inactive (103.14%) |
NuaK2 | inactive (101%) |
MARK2 | inactive (104.97%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (105.49%) |
CaMK1b | inactive (96.55%) |
CaMK1d | inactive (108.84%) |
CaMK1g | inactive (95.02%) |
CaMK4 | inactive (97.7%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (101.04%) |
CaMK2b | inactive (99.27%) |
CaMK2d | inactive (109.48%) |
CaMK2g | inactive (98.97%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (103.17%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (91.3%) |
DAPK2 | inactive (107.02%) |
DRAK1 | inactive (103.49%) |
DAPK3 | inactive (104.72%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (101.59%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (97.93%) |
MAPKAPK3 | inactive (98.89%) |
MAPKAPK5 | inactive (100.62%) |
MNK1 | inactive (89.46%) |
MNK2 | inactive (101.46%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (94.84%) |
skMLCK | inactive (101.28%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (92.89%) |
PHKg2 | inactive (93.53%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (101.75%) |
PIM2 | inactive (116.22%) |
PIM3 | inactive (106.74%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (93.22%) |
PKD3 | inactive (93.35%) |
PKD2 | inactive (96.93%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (93.43%) |
TSSK2 | inactive (100.49%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (93.69%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (97.16%) |
MAP3K2 | inactive (101.91%) |
MAP3K3 | inactive (112.49%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (90.82%) |
NIK | inactive (95.81%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (105.03%) |
HGK | inactive (95.12%) |
KHS1 | inactive (96.51%) |
LOK | inactive (92.6%) |
MINK | inactive (96.81%) |
MST1 | inactive (97.47%) |
MST2 | inactive (95.45%) |
MST3 | inactive (100.73%) |
MST4 | inactive (98.03%) |
OSR1 | inactive (99.7%) |
PAK1 | inactive (103.73%) |
PAK2 | inactive (112.52%) |
PAK3 | inactive (100.94%) |
PAK4 | inactive (107.13%) |
PAK5 | inactive (89.4%) |
PAK6 | inactive (99.99%) |
SLK | inactive (92.82%) |
YSK1 | inactive (91.77%) |
STLK3 | inactive (88.26%) |
TAO1 | inactive (101.63%) |
TAO2 | inactive (105.01%) |
TAO3 | inactive (93.03%) |
MYO3B | inactive (93.73%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (119.83%) |
MAP2K2 | inactive (113.71%) |
MAP2K6 | inactive (100.27%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (110.72%) |
AurB | inactive (98.01%) |
AurC | inactive (97.15%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (96.66%) |
CaMKK2 | inactive (100.73%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (105.41%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (96.78%) |
IKKb | inactive (98.61%) |
IKKe | inactive (94.85%) |
TBK1 | inactive (101.26%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (94.45%) |
NEK11 | inactive (97.65%) |
NEK2 | inactive (96.21%) |
NEK4 | inactive (90.03%) |
NEK6 | inactive (92.63%) |
NEK7 | inactive (94.57%) |
NEK9 | inactive (95.51%) |
NEK3 | inactive (100.32%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (99.9%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (98.33%) |
PLK2 | inactive (99.74%) |
PLK3 | inactive (106.81%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (88.75%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (103.92%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (111%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (87.18%) |
ULK2 | inactive (99.62%) |
ULK3 | inactive (99.51%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (101.26%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (95.87%) |
Wnk3 | inactive (98.51%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | inactive (98.57%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (96.59%) |
CK1g1 | inactive (100.34%) |
CK1g2 | inactive (96.66%) |
CK1g3 | inactive (96.68%) |
CK1a | inactive (98.4%) |
CK1e | inactive (95.5%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (99.77%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (97.53%) |
CK2a2 | inactive (101.89%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (100.68%) |
CLK2 | inactive (89.57%) |
CLK3 | inactive (92.24%) |
CLK4 | inactive (100.97%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (105.03%) |
DYRK1B | inactive (96.67%) |
DYRK2 | inactive (109.69%) |
DYRK3 | inactive (108.58%) |
DYRK4 | inactive (100.7%) |
HIPK1 | inactive (100.76%) |
HIPK2 | inactive (90.25%) |
HIPK3 | inactive (100.13%) |
HIPK4 | inactive (104.96%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (100.02%) |
Erk2 | inactive (88.62%) |
JNK3 | inactive (94.61%) |
NLK | inactive (100.84%) |
p38a | inactive (103.11%) |
p38b | inactive (102.5%) |
p38d | inactive (99.12%) |
p38g | inactive (98.25%) |
JNK1 | inactive (105.05%) |
JNK2 | inactive (106.23%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (102.09%) |
GSK3B | inactive (100.04%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (103.9%) |
SRPK1 | inactive (98.07%) |
SRPK2 | inactive (100.61%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (103.58%) |