Compound Information
Test on : GPCR
Compound Name : GW779439X
Inchikey : ZOTNSCLLJKXGSD-UHFFFAOYSA-N
ChemSpider : 8349301
Pubchem CID : 10173796
ChEMBL : CHEMBL468963
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (17.57%) |
TYK2 | inactive (8.28%) |
JAK2 | inactive (30.27%) |
JAK3 | inactive (49.24%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (37.32%) |
FES | inactive (40.23%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (63.34%) |
ABL2 | active (57.29%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (7.32%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (13.74%) |
BTK | inactive (5.93%) |
TXK | inactive (21.32%) |
TEC | inactive (22.94%) |
ITK | inactive (13.52%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (28.47%) |
SRM | inactive (3.44%) |
FRK | inactive (15.43%) |
BLK | inactive (15.74%) |
LCK | inactive (34.35%) |
HCK | inactive (32.57%) |
FGR | inactive (47.52%) |
FYN | inactive (32.2%) |
SRC | active (62.62%) |
YES | active (50.21%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-0.78%) |
EphA4 | inactive (14.66%) |
EphA3 | inactive (6.24%) |
EphB4 | inactive (26.79%) |
EphB3 | inactive (0.09%) |
EphB2 | active (57.9%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (72.39%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (47.48%) |
ZAP70 | inactive (11.75%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (28.47%) |
ALK | active (62.85%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (91.83%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (93.61%) |
IGF1R | active (84.04%) |
IRR | inactive (24.85%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (18.12%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (60.32%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (17.31%) |
TRKB | inactive (12.69%) |
TRKC | inactive (18.42%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (28%) |
MET | inactive (27.11%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | active (58.84%) |
MER | inactive (29.6%) |
TYRO3 | inactive (22.92%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (35.72%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (5.49%) |
FGFR2 | inactive (19.08%) |
FGFR3 | inactive (14.99%) |
FGFR4 | inactive (1.16%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (28.38%) |
KDR | active (58.72%) |
FLT4 | inactive (25.51%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (92.15%) |
KIT | active (107.78%) |
FLT3 | active (86.35%) |
PDGFRa | active (78.69%) |
PDGFRb | active (90.85%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (31.09%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (9.11%) |
TNK1 | active (64.37%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (6.43%) |
ErbB2 | inactive (2.62%) |
ErbB4 | inactive (14.77%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (32.39%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (22.4%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | active (55.74%) |
MST1 | inactive (22.92%) |
MST2 | inactive (10.05%) |
MST4 | inactive (0.67%) |
HGK | active (64.78%) |
MINK | active (54.8%) |
LOK | inactive (47.04%) |
PAK1 | inactive (39.85%) |
PAK3 | inactive (17.16%) |
PAK2 | inactive (37.84%) |
PAK5 | inactive (43.21%) |
PAK6 | inactive (7.31%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (17.84%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | active (91.58%) |
CK1g2 | active (76.8%) |
CK1g1 | active (61.12%) |
CK1g3 | active (79.91%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (5.67%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (56.46%) |
AurC | active (88.27%) |
AurA | active (74.19%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (11.41%) |
NEK2 | inactive (11.7%) |
NEK9 | inactive (45.37%) |
NEK7 | inactive (1.08%) |
NEK6 | inactive (-1.49%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | active (57.28%) |
IKKe | inactive (48.53%) |
IKKb | inactive (18.16%) |
IKKa | inactive (39.48%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (32.34%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (8.59%) |
GPRK6 | inactive (3.87%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (8.42%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (22.41%) |
MSK2 | inactive (7.3%) |
RSK1 | inactive (18.54%) |
RSK2 | inactive (23.82%) |
RSK4 | inactive (27.89%) |
RSK3 | inactive (20.48%) |
p70S6K | inactive (7.77%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.56%) |
AKT1 | inactive (0.16%) |
AKT3 | inactive (3.07%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (18.12%) |
SGK3 | inactive (0.08%) |
SGK2 | inactive (3.07%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | active (61.51%) |
PKCg | inactive (37.09%) |
PKCa | active (77.34%) |
PKCt | active (57.16%) |
PKCi | inactive (2.12%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | active (60.53%) |
PKG1 | inactive (24.8%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.22%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (25.97%) |
ROCK2 | inactive (38.8%) |
MRCKb | inactive (21.59%) |
MRCKa | inactive (21.55%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (10.15%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (38.87%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (7.85%) |
CaMK1d | inactive (18.51%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | active (69.44%) |
PHKg2 | inactive (25.72%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | active (56.74%) |
CaMK2a | inactive (22.62%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.45%) |
MAPKAPK2 | inactive (0.62%) |
MAPKAPK3 | inactive (2.23%) |
MNK2 | inactive (24.54%) |
MNK1 | inactive (17.51%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | active (83.97%) |
PKD1 | active (79.43%) |
PKD2 | active (81.04%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (26.76%) |
MARK3 | inactive (45.99%) |
MARK1 | inactive (35.38%) |
QIK | inactive (47.08%) |
SIK | inactive (39.09%) |
NuaK1 | active (91.9%) |
BRSK1 | inactive (6.62%) |
BRSK2 | inactive (8.68%) |
MELK | active (76.76%) |
CHK1 | inactive (11.47%) |
PASK | inactive (18.65%) |
AMPKa1 | inactive (26.86%) |
AMPKa2 | inactive (34.75%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.56%) |
TSSK1 | inactive (45.28%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.71%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | active (51.76%) |
PIM3 | active (71.31%) |
PIM1 | active (68.43%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (36.85%) |
p38a | inactive (14.27%) |
p38b | inactive (9.37%) |
p38d | inactive (20.97%) |
Erk2 | inactive (14.19%) |
Erk1 | inactive (5.15%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (94.53%) |
GSK3B | active (93.33%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.07%) |
MSSK1 | inactive (-2.9%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (42.45%) |
CLK2 | active (100.15%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (93.77%) |
HIPK4 | active (90.76%) |
DYRK1B | active (92.87%) |
DYRK1A | active (92.58%) |
DYRK2 | inactive (44.97%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (47.13%) |