Compound Information


Test on : Metz

Compound Name : Kinome_1054

Inchikey : ZGZVRPRSFXRGCF-UHFFFAOYSA-N

ChemSpider : 24808970

Pubchem CID : 49830457

ChEMBL : CHEMBL1991078




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
33
73
71
11
52
95
22
31
84
31
AGC - Akt

Bioactivity
KinaseMetz
AKT1inactive (6309.57nM)
AKT2inactive (>7943.28nM)
AKT3inactive (1258.93nM)
AGC - DMPK

Bioactivity
KinaseMetz
MRCKainactive (6309.57nM)
ROCK1inactive (1258.93nM)
ROCK2active (794.33nM)
AGC - GRK

Bioactivity
KinaseMetz
GPRK5active (398.11nM)
AGC - PDK1

Bioactivity
KinaseMetz
PDK1active (1000nM)
AGC - PKA

Bioactivity
KinaseMetz
PKACaactive (501.19nM)
PRKXactive (50.12nM)
AGC - PKC

Bioactivity
KinaseMetz
PKCdinactive (3162.28nM)
PKCgactive (125.89nM)
PKCzinactive (>7943.28nM)
PKCiinactive (3981.07nM)
PKCt-
AGC - PKG

Bioactivity
KinaseMetz
PKG1active (630.96nM)
PKG2inactive (>1584.89nM)
AGC - PKN

Bioactivity
KinaseMetz
PKN2active (501.19nM)
AGC - RSK

Bioactivity
KinaseMetz
RSK2inactive (1258.93nM)
p70S6Kactive (100nM)
MSK1-
MSK2-
AGC - SGK

Bioactivity
KinaseMetz
SGK1active (1000nM)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseMetz
61
Atypical - Alpha

Bioactivity
KinaseMetz
eEF2K-

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
52
44
209
52
31
54
21
33
32
11
11
52
CAMK - CAMK1

Bioactivity
KinaseMetz
CaMK1ainactive (>1584.89nM)
CaMK1dactive (251.19nM)
CAMK - CAMK2

Bioactivity
KinaseMetz
CaMK2binactive (1258.93nM)
CaMK2dactive (794.33nM)
CaMK2gactive (316.23nM)
CaMK2aactive (398.11nM)
CAMK - CAMKL

Bioactivity
KinaseMetz
CHK1inactive (3981.07nM)
BRSK1inactive (1258.93nM)
MARK2-
MARK3active (63.1nM)
MELKactive (398.11nM)
AMPKa1active (63.1nM)
PASK-
MARK4-
QIK-
CAMK - DAPK

Bioactivity
KinaseMetz
DAPK3active (31.62nM)
DRAK1active (50.12nM)
CAMK - DCAMKL

Bioactivity
KinaseMetz
DCLK1inactive (5011.87nM)
CAMK - MAPKAPK

Bioactivity
KinaseMetz
MAPKAPK2inactive (1995.26nM)
MAPKAPK3inactive (>10000nM)
MNK2inactive (3162.28nM)
MAPKAPK5inactive (1258.93nM)
CAMK - PHK

Bioactivity
KinaseMetz
PHKg2active (316.23nM)
CAMK - PIM

Bioactivity
KinaseMetz
PIM1inactive (>5011.87nM)
PIM2inactive (>2511.89nM)
PIM3inactive (1258.93nM)
CAMK - PKD

Bioactivity
KinaseMetz
PKD3inactive (1584.89nM)
PKD2inactive (1995.26nM)
CAMK - RAD53

Bioactivity
KinaseMetz
CHK2active (50.12nM)
CAMK - STK33

Bioactivity
KinaseMetz
STK33-
CAMK - TSSK

Bioactivity
KinaseMetz
TSSK1inactive (>1584.89nM)
TSSK2active (79.43nM)

CK1


Test Member No. in Family
Familyno. Member on 518kinaseMetz
75
CK1 - CK1

Bioactivity
KinaseMetz
CK1aactive (398.11nM)
CK1dactive (1000nM)
CK1g1active (25.12nM)
CK1g2active (6.31nM)
CK1g3active (79.43nM)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
207
31
42
106
22
148
31
CMGC - CDK

Bioactivity
KinaseMetz
CDC2active (39.81nM)
CDK2active (12.59nM)
CDK5active (12.59nM)
CDK8inactive (>3981.07nM)
CDK7active (125.89nM)
CDK9active (501.19nM)
CDK11-
CMGC - CK2

Bioactivity
KinaseMetz
CK2a1active (15.85nM)
CMGC - CLK

Bioactivity
KinaseMetz
CLK2active (63.1nM)
CLK4-
CMGC - DYRK

Bioactivity
KinaseMetz
DYRK1Aactive (100nM)
DYRK3active (630.96nM)
DYRK4inactive (6309.57nM)
HIPK2active (25.12nM)
HIPK4active (1000nM)
DYRK1Bactive (15.85nM)
CMGC - GSK

Bioactivity
KinaseMetz
GSK3A-
GSK3Binactive (>100nM)
CMGC - MAPK

Bioactivity
KinaseMetz
Erk2active (100nM)
p38gactive (630.96nM)
p38dactive (501.19nM)
JNK1active (630.96nM)
JNK2active (251.19nM)
p38ainactive (>3981.07nM)
JNK3-
NLK-
CMGC - SRPK

Bioactivity
KinaseMetz
SRPK1inactive (1584.89nM)

Other


Test Member No. in Family
Familyno. Member on 518kinaseMetz
32
21
11
44
112
43
11
31
Other - Aur

Bioactivity
KinaseMetz
AurBactive (199.53nM)
AurAactive (398.11nM)
Other - CAMKK

Bioactivity
KinaseMetz
CaMKK2-
Other - CDC7

Bioactivity
KinaseMetz
CDC7active (1.26nM)
Other - IKK

Bioactivity
KinaseMetz
IKKeactive (199.53nM)
TBK1active (25.12nM)
IKKa-
IKKb-
Other - NEK

Bioactivity
KinaseMetz
NEK2inactive (6309.57nM)
NEK4active (1000nM)
Other - PLK

Bioactivity
KinaseMetz
PLK1inactive (>7943.28nM)
PLK3-
PLK4active (79.43nM)
Other - TOPK

Bioactivity
KinaseMetz
PBKinactive (>10000nM)
Other - WEE

Bioactivity
KinaseMetz
Wee1-

STE


Test Member No. in Family
Familyno. Member on 518kinaseMetz
319
72
STE - STE20

Bioactivity
KinaseMetz
GCKactive (398.11nM)
HGKactive (501.19nM)
KHS1active (501.19nM)
MINKactive (251.19nM)
PAK1inactive (>10000nM)
PAK4active (501.19nM)
SLKinactive (1995.26nM)
MST2active (794.33nM)
TAO1inactive (5011.87nM)
STE - STE7

Bioactivity
KinaseMetz
MAP2K1inactive (1258.93nM)
MAP2K2-

TK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
21
21
22
32
21
43
141
22
22
42
32
43
22
55
11
11
119
21
53
33
33
TK - Abl

Bioactivity
KinaseMetz
ABL1inactive (>630.96nM)
TK - Ack

Bioactivity
KinaseMetz
ACKinactive (>3981.07nM)
TK - ALK

Bioactivity
KinaseMetz
ALKinactive (>6309.57nM)
LTKinactive (>2511.89nM)
TK - Axl

Bioactivity
KinaseMetz
TYRO3inactive (>1995.26nM)
AXL-
TK - Csk

Bioactivity
KinaseMetz
CTKinactive (>1995.26nM)
TK - EGFR

Bioactivity
KinaseMetz
EGFRinactive (>1995.26nM)
ErbB2-
ErbB4inactive (>3981.07nM)
TK - Eph

Bioactivity
KinaseMetz
EphA2inactive (>3162.28nM)
TK - FAK

Bioactivity
KinaseMetz
FAKinactive (>6309.57nM)
PYK2-
TK - Fer

Bioactivity
KinaseMetz
FERactive (251.19nM)
FESinactive (>1995.26nM)
TK - FGFR

Bioactivity
KinaseMetz
FGFR1active (501.19nM)
FGFR3active (158.49nM)
TK - InsR

Bioactivity
KinaseMetz
IGF1Rinactive (>1995.26nM)
INSRinactive (1258.93nM)
TK - JakA

Bioactivity
KinaseMetz
JAK2active (125.89nM)
JAK3active (1000nM)
TYK2active (19.95nM)
TK - Met

Bioactivity
KinaseMetz
METinactive (>3162.28nM)
RONactive (794.33nM)
TK - PDGFR

Bioactivity
KinaseMetz
FMSinactive (>1584.89nM)
FLT3inactive (>1258.93nM)
KITinactive (>1258.93nM)
PDGFRa-
PDGFRb-
TK - Ret

Bioactivity
KinaseMetz
RETactive (125.89nM)
TK - Sev

Bioactivity
KinaseMetz
ROS-
TK - Src

Bioactivity
KinaseMetz
BLKinactive (1258.93nM)
LCKinactive (2511.89nM)
LYNactive (501.19nM)
SRCactive (316.23nM)
FRKactive (79.43nM)
SRMinactive (>1584.89nM)
FYNactive (251.19nM)
BRK-
HCK-
TK - Syk

Bioactivity
KinaseMetz
SYKactive (19.95nM)
TK - Tec

Bioactivity
KinaseMetz
BTKinactive (>3981.07nM)
ITK-
BMX-
TK - Trk

Bioactivity
KinaseMetz
TRKAinactive (1584.89nM)
TRKBinactive (>5011.87nM)
TRKCactive (79.43nM)
TK - VEGFR

Bioactivity
KinaseMetz
FLT4active (199.53nM)
KDRactive (398.11nM)
FLT1active (199.53nM)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseMetz
42
41
21
102
51
121
TKL - IRAK

Bioactivity
KinaseMetz
IRAK1-
IRAK4inactive (2511.89nM)
TKL - LISK

Bioactivity
KinaseMetz
LIMK1-
TKL - LRRK

Bioactivity
KinaseMetz
LRRK2active (501.19nM)
TKL - MLK

Bioactivity
KinaseMetz
ZAKinactive (7943.28nM)
MLK2-
TKL - RAF

Bioactivity
KinaseMetz
BRAF-
TKL - STKR

Bioactivity
KinaseMetz
ALK2active (1000nM)