Compound Information
Test on : RBC
Compound Name : GSK-3beta Inhibitor XI
Inchikey : ZDEJZKULWCZIHL-UHFFFAOYSA-N
ChemSpider : 8196286
Pubchem CID : 10020713
ChEMBL : CHEMBL272629
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (92.24%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (98.61%) |
AKT2 | inactive (113.92%) |
AKT3 | inactive (101.31%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (99.58%) |
MRCKa | inactive (78.62%) |
MRCKb | inactive (101.78%) |
ROCK1 | inactive (90.24%) |
ROCK2 | inactive (95.97%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (113.78%) |
BARK2 | inactive (99.89%) |
GPRK4 | inactive (90.13%) |
GPRK5 | inactive (115.75%) |
GPRK6 | inactive (102.25%) |
GPRK7 | inactive (117.82%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (73.91%) |
MSK2 | inactive (100.98%) |
p70S6K | inactive (90.15%) |
p70S6Kb | inactive (94.72%) |
RSK2 | inactive (91.34%) |
RSK4 | inactive (73.04%) |
RSK1 | inactive (94.77%) |
RSK3 | inactive (73.16%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | inactive (106.49%) |
PKACa | inactive (87.7%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (91.11%) |
PKCd | inactive (97.02%) |
PKCe | inactive (101.81%) |
PKCh | inactive (81.6%) |
PKCg | inactive (93.07%) |
PKCi | inactive (86.97%) |
PKCt | inactive (81.73%) |
PKCz | inactive (88.47%) |
PKCb | inactive (102.43%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (117.63%) |
PKG1 | inactive (131.21%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (97.77%) |
PKN2 | inactive (83.27%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (91.19%) |
SGK2 | inactive (96.89%) |
SGK3 | inactive (124.16%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (98.88%) |
ABL2 | inactive (83.73%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (90.7%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (104.53%) |
LTK | inactive (90.86%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (103.99%) |
MER | inactive (78.73%) |
TYRO3 | inactive (93.68%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (87.14%) |
BRK | inactive (101.26%) |
SRC | inactive (78.86%) |
FGR | inactive (107.69%) |
FRK | inactive (88.34%) |
FYN | inactive (107.03%) |
HCK | inactive (63.45%) |
LCK | inactive (95.85%) |
SRM | inactive (95.93%) |
YES | inactive (80.15%) |
LYN | inactive (112.33%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (97.77%) |
BTK | inactive (93.66%) |
ITK | inactive (84.65%) |
TEC | inactive (119.82%) |
TXK | inactive (75.32%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (93.01%) |
FLT3 | inactive (87.83%) |
FMS | inactive (98.42%) |
PDGFRb | inactive (102.49%) |
PDGFRa | inactive (112.66%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (86.92%) |
CTK | inactive (95.54%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (94.63%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (95.86%) |
ErbB2 | inactive (106.06%) |
ErbB4 | inactive (115.2%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (73.9%) |
EphA2 | inactive (105.22%) |
EphA3 | inactive (101.63%) |
EphA4 | inactive (99.5%) |
EphA5 | inactive (99.37%) |
EphA6 | - |
EphA7 | inactive (104.88%) |
EphA8 | inactive (86.91%) |
EphB1 | inactive (108.76%) |
EphB2 | inactive (78.26%) |
EphB3 | inactive (86.62%) |
EphB4 | inactive (95.16%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (100.52%) |
PYK2 | inactive (94.01%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (99.2%) |
FES | inactive (120.9%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (81.18%) |
FGFR2 | inactive (102.88%) |
FGFR3 | inactive (78.71%) |
FGFR4 | inactive (91.52%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (89.4%) |
FLT4 | inactive (92.3%) |
KDR | inactive (82.06%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (98.37%) |
IRR | inactive (93.21%) |
INSR | inactive (92.93%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (116.87%) |
JAK2 | inactive (97.81%) |
JAK3 | inactive (134.23%) |
TYK2 | inactive (96.88%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (67.15%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (54.53%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (96.12%) |
MET | inactive (120.57%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (106.33%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (60%) |
ZAP70 | inactive (87.78%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (103.13%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (88.09%) |
TRKB | inactive (99.7%) |
TRKC | inactive (79.66%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (104.97%) |
ALK2 | inactive (96.99%) |
ALK4 | inactive (100.14%) |
TGFbR1 | inactive (98.49%) |
TGFbR2 | inactive (122.03%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (93.55%) |
BRAF | inactive (99.54%) |
RAF1 | inactive (100.01%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (76.56%) |
IRAK4 | inactive (129.21%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (96.37%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (90.01%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (85.49%) |
MLK2 | inactive (91.31%) |
MLK3 | inactive (80.83%) |
TAK1 | inactive (95.54%) |
ZAK | inactive (96.37%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (90.94%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (59.43%) |
BRSK1 | inactive (89.17%) |
BRSK2 | inactive (90.36%) |
CHK1 | inactive (141.17%) |
LKB1 | inactive (83.07%) |
MARK1 | inactive (94.98%) |
MARK3 | inactive (87.84%) |
MARK4 | inactive (93.86%) |
MELK | inactive (100.74%) |
PASK | inactive (97.11%) |
QIK | inactive (100.65%) |
NuaK2 | inactive (92.27%) |
MARK2 | inactive (97.49%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (101.16%) |
CaMK1b | inactive (94.87%) |
CaMK1d | inactive (95.11%) |
CaMK1g | inactive (101.24%) |
CaMK4 | inactive (95.64%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (107.77%) |
CaMK2b | inactive (97.56%) |
CaMK2d | inactive (100.54%) |
CaMK2g | inactive (90.6%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (97.7%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (74.36%) |
DAPK2 | inactive (88.41%) |
DRAK1 | inactive (93.62%) |
DAPK3 | inactive (80.16%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (90.12%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (90.97%) |
MAPKAPK3 | inactive (102.58%) |
MAPKAPK5 | inactive (98.63%) |
MNK1 | inactive (100.27%) |
MNK2 | inactive (69.06%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (74.04%) |
skMLCK | inactive (81.14%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (87.21%) |
PHKg2 | inactive (101.73%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | active (43.9%) |
PIM2 | inactive (92.67%) |
PIM3 | active (16.66%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (106.53%) |
PKD3 | inactive (78.17%) |
PKD2 | inactive (117.82%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (94.9%) |
TSSK2 | inactive (118.59%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (82.83%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (88.91%) |
MAP3K2 | inactive (96.93%) |
MAP3K3 | inactive (88.27%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (96.96%) |
NIK | inactive (78.1%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (67.43%) |
HGK | active (36.44%) |
KHS1 | active (37.54%) |
LOK | inactive (103.77%) |
MINK | inactive (84.75%) |
MST1 | inactive (83.63%) |
MST2 | inactive (74.43%) |
MST3 | inactive (72.05%) |
MST4 | inactive (78.68%) |
OSR1 | inactive (100.8%) |
PAK1 | inactive (100.51%) |
PAK2 | inactive (105.02%) |
PAK3 | inactive (92.85%) |
PAK4 | inactive (110.59%) |
PAK5 | inactive (88.18%) |
PAK6 | inactive (78.18%) |
SLK | inactive (106.41%) |
YSK1 | inactive (78.92%) |
STLK3 | inactive (111.16%) |
TAO1 | inactive (132.33%) |
TAO2 | inactive (88.11%) |
TAO3 | inactive (88.17%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (106.29%) |
MAP2K2 | inactive (90.31%) |
MAP2K6 | inactive (91.06%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (107.17%) |
AurB | inactive (101.39%) |
AurC | inactive (113.44%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (106.64%) |
CaMKK2 | inactive (115.49%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (91.94%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (100.76%) |
IKKb | inactive (87.29%) |
IKKe | inactive (90.03%) |
TBK1 | inactive (98.78%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (91.92%) |
NEK11 | inactive (107.55%) |
NEK2 | inactive (97.49%) |
NEK4 | inactive (85.11%) |
NEK6 | inactive (94.23%) |
NEK7 | inactive (95.37%) |
NEK9 | inactive (93.36%) |
NEK3 | inactive (97.51%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (94.87%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (102.74%) |
PLK2 | inactive (103.76%) |
PLK3 | inactive (91.08%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (78.04%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (90.27%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (94.53%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (102.2%) |
ULK2 | inactive (96.66%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (96.19%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (104.18%) |
Wnk3 | inactive (91.29%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (99.37%) |
CK1g1 | inactive (100.84%) |
CK1g2 | inactive (66.01%) |
CK1g3 | inactive (106.62%) |
CK1a | inactive (66.99%) |
CK1e | inactive (93.92%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (86.4%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (78.86%) |
CK2a2 | - |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (88.45%) |
CLK2 | inactive (98.92%) |
CLK3 | inactive (67.81%) |
CLK4 | inactive (99.97%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (107.64%) |
DYRK1B | inactive (93.25%) |
DYRK2 | inactive (81.67%) |
DYRK3 | inactive (79.63%) |
DYRK4 | inactive (98.42%) |
HIPK1 | inactive (84.15%) |
HIPK2 | inactive (96.58%) |
HIPK3 | inactive (89.15%) |
HIPK4 | inactive (104.41%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (94.46%) |
Erk2 | inactive (81.94%) |
JNK3 | inactive (87.97%) |
NLK | inactive (91.24%) |
p38a | inactive (106.56%) |
p38b | inactive (104.61%) |
p38d | inactive (96.48%) |
p38g | inactive (86.78%) |
JNK1 | inactive (99.55%) |
JNK2 | inactive (100.29%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | active (8.56%) |
GSK3B | active (25.18%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (91.15%) |
SRPK1 | inactive (97.99%) |
SRPK2 | inactive (97.93%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (92.24%) |