Compound in Profiling

Compound Information

Test on : DRx, Metz

Compound Name
DRx : Ruboxistaurin
Metz : Kinome_3136

Inchikey
Same : ZCBUQCWBWNUWSU-N
DRx : ZCBUQCWBWNUWSU-SFHVURJKSA-N
Metz : ZCBUQCWBWNUWSU-UHFFFAOYSA-N

ChemSpider
DRx : 135727
Metz : 8068036

Pubchem CID
DRx : 153999
Metz : 9892366

ChEMBL
DRx : CHEMBL432130
Metz : CHEMBL360847

DRx	Metz

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
NAK	4	4	-
Aur	3	3	2
CAMKK	2	2	1
PEK	4	2	-
IRE	2	1	-
IKK	4	4	4
NEK	11	9	2
WEE	3	3	1
PLK	4	4	3
SgK496	1	1	-
NKF1	3	2	-
NKF4	2	1	-
ULK	5	4	-
TLK	2	2	-
TTK	1	1	-
CDC7	1	-	1
TOPK	1	-	1

Other - NAK

Bioactivity
Kinase	DRx	Metz
AAK1	active (900nM)	-
BIKE	active (430nM)	-
GAK	active (1100nM)	-
MPSK1	inactive (10001nM)	-

Other - Aur

Bioactivity
Kinase	DRx	Metz
AurA	inactive (10001nM)	inactive (>1584.89nM)
AurB	inactive (10001nM)	inactive (>3981.07nM)
AurC	inactive (10001nM)	-

Other - CAMKK

Bioactivity
Kinase	DRx	Metz
CaMKK1	inactive (5000nM)	-
CaMKK2	active (2400nM)	-

Other - PEK

Bioactivity
Kinase	DRx	Metz
HRI	inactive (10001nM)	-
PKR	inactive (10001nM)	-

Other - IRE

Bioactivity
Kinase	DRx	Metz
IRE1	inactive (10001nM)	-

Other - IKK

Bioactivity
Kinase	DRx	Metz
IKKa	inactive (10001nM)	-
IKKb	inactive (10001nM)	-
IKKe	inactive (10001nM)	inactive (>3162.28nM)
TBK1	active (970nM)	active (501.19nM)

Other - NEK

Bioactivity
Kinase	DRx	Metz
NEK1	inactive (10001nM)	-
NEK11	inactive (10001nM)	-
NEK2	inactive (10001nM)	inactive (>3162.28nM)
NEK3	inactive (10001nM)	-
NEK4	inactive (10001nM)	-
NEK5	inactive (10001nM)	-
NEK6	inactive (10001nM)	-
NEK7	inactive (10001nM)	-
NEK9	inactive (10001nM)	-

Other - WEE

Bioactivity
Kinase	DRx	Metz
MYT1	inactive (10001nM)	-
Wee1	inactive (10001nM)	-
Wee1B	inactive (10001nM)	-

Other - PLK

Bioactivity
Kinase	DRx	Metz
PLK1	inactive (10001nM)	-
PLK2	inactive (10001nM)	-
PLK3	inactive (10001nM)	-
PLK4	inactive (4700nM)	-

Other - SgK496

Bioactivity
Kinase	DRx	Metz
SgK496	inactive (10001nM)	-

Other - NKF1

Bioactivity
Kinase	DRx	Metz
SBK	inactive (10001nM)	-
SgK110	inactive (10001nM)	-

Other - NKF4

Bioactivity
Kinase	DRx	Metz
CLIK1	inactive (10001nM)	-

Other - ULK

Bioactivity
Kinase	DRx	Metz
Fused	inactive (10001nM)	-
ULK1	inactive (10001nM)	-
ULK2	inactive (10001nM)	-
ULK3	inactive (10001nM)	-

Other - TLK

Bioactivity
Kinase	DRx	Metz
TLK1	active (2100nM)	-
TLK2	inactive (10001nM)	-

Other - TTK

Bioactivity
Kinase	DRx	Metz
TTK	inactive (10001nM)	-

Other - CDC7

Bioactivity
Kinase	DRx	Metz
CDC7	-	-

Other - TOPK

Bioactivity
Kinase	DRx	Metz
PBK	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
Abl	2	2	1
ALK	2	2	2
Axl	3	3	2
Src	11	11	9
Tec	5	5	3
PDGFR	5	5	5
Csk	2	2	1
DDR	2	2	-
EGFR	4	4	3
Eph	14	13	1
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	2
VEGFR	3	3	3
InsR	3	3	2
JakA	4	4	3
Met	2	2	2
Musk	1	1	-
Ret	1	1	1
Sev	1	1	1
Syk	2	2	1
Tie	2	2	-
Ack	2	2	1
Trk	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	Metz
ABL1	inactive (10001nM)	inactive (>2511.89nM)
ABL2	inactive (10001nM)	-

TK - ALK

Bioactivity
Kinase	DRx	Metz
ALK	inactive (10001nM)	inactive (3162.28nM)
LTK	inactive (10001nM)	inactive (>2511.89nM)

TK - Axl

Bioactivity
Kinase	DRx	Metz
AXL	inactive (10001nM)	-
MER	inactive (10001nM)	-
TYRO3	inactive (10001nM)	inactive (>3162.28nM)

TK - Src

Bioactivity
Kinase	DRx	Metz
BLK	inactive (10001nM)	-
BRK	inactive (10001nM)	-
FGR	inactive (10001nM)	-
FRK	inactive (10001nM)	-
FYN	inactive (10001nM)	inactive (>6309.57nM)
HCK	inactive (10001nM)	-
LCK	inactive (10001nM)	inactive (>6309.57nM)
LYN	inactive (10001nM)	-
SRC	inactive (10001nM)	-
SRM	inactive (10001nM)	-
YES	inactive (10001nM)	-

TK - Tec

Bioactivity
Kinase	DRx	Metz
BMX	inactive (10001nM)	-
BTK	inactive (10001nM)	inactive (>6309.57nM)
ITK	inactive (10001nM)	-
TEC	inactive (10001nM)	-
TXK	inactive (10001nM)	-

TK - PDGFR

Bioactivity
Kinase	DRx	Metz
FMS	inactive (10001nM)	inactive (>2511.89nM)
FLT3	active (1900nM)	inactive (>3162.28nM)
KIT	inactive (10001nM)	-
PDGFRa	inactive (10001nM)	inactive (>2511.89nM)
PDGFRb	inactive (10001nM)	inactive (>1995.26nM)

TK - Csk

Bioactivity
Kinase	DRx	Metz
CSK	inactive (10001nM)	-
CTK	inactive (10001nM)	-

TK - DDR

Bioactivity
Kinase	DRx	Metz
DDR1	inactive (10001nM)	-
DDR2	inactive (10001nM)	-

TK - EGFR

Bioactivity
Kinase	DRx	Metz
EGFR	inactive (10001nM)	-
ErbB2	inactive (10001nM)	-
ErbB3	inactive (10001nM)	-
ErbB4	inactive (10001nM)	-

TK - Eph

Bioactivity
Kinase	DRx	Metz
EphA1	inactive (10001nM)	-
EphA2	inactive (10001nM)	-
EphA3	inactive (10001nM)	-
EphA4	inactive (10001nM)	-
EphA5	inactive (10001nM)	-
EphA6	inactive (10001nM)	-
EphA7	inactive (10001nM)	-
EphA8	inactive (10001nM)	-
EphB1	inactive (10001nM)	-
EphB2	inactive (10001nM)	-
EphB3	inactive (10001nM)	-
EphB4	inactive (10001nM)	-
EphB6	inactive (10001nM)	-

TK - FAK

Bioactivity
Kinase	DRx	Metz
FAK	inactive (10001nM)	inactive (>6309.57nM)
PYK2	inactive (10001nM)	-

TK - Fer

Bioactivity
Kinase	DRx	Metz
FER	inactive (10001nM)	-
FES	inactive (10001nM)	-

TK - FGFR

Bioactivity
Kinase	DRx	Metz
FGFR1	inactive (10001nM)	inactive (>3981.07nM)
FGFR2	inactive (10001nM)	-
FGFR3	inactive (10001nM)	-
FGFR4	inactive (10001nM)	-

TK - VEGFR

Bioactivity
Kinase	DRx	Metz
FLT1	inactive (10001nM)	inactive (>3981.07nM)
FLT4	inactive (10001nM)	-
KDR	inactive (10001nM)	inactive (1995.26nM)

TK - InsR

Bioactivity
Kinase	DRx	Metz
IGF1R	inactive (10001nM)	inactive (>2511.89nM)
INSR	inactive (10001nM)	-
IRR	inactive (10001nM)	-

TK - JakA

Bioactivity
Kinase	DRx	Metz
JAK1	inactive (10001nM)	-
JAK2	inactive (10001nM)	inactive (>2511.89nM)
JAK3	active (1200nM)	inactive (1995.26nM)
TYK2	inactive (10001nM)	-

TK - Met

Bioactivity
Kinase	DRx	Metz
MET	inactive (10001nM)	inactive (>2511.89nM)
RON	inactive (10001nM)	active (199.53nM)

TK - Musk

Bioactivity
Kinase	DRx	Metz
MUSK	inactive (10001nM)	-

TK - Ret

Bioactivity
Kinase	DRx	Metz
RET	inactive (10001nM)	inactive (>3162.28nM)

TK - Sev

Bioactivity
Kinase	DRx	Metz
ROS	inactive (5800nM)	-

TK - Syk

Bioactivity
Kinase	DRx	Metz
SYK	inactive (10001nM)	-
ZAP70	inactive (10001nM)	-

TK - Tie

Bioactivity
Kinase	DRx	Metz
TIE1	inactive (10001nM)	-
TIE2	inactive (10001nM)	-

TK - Ack

Bioactivity
Kinase	DRx	Metz
TNK1	inactive (10001nM)	-
ACK	inactive (10001nM)	inactive (>3981.07nM)

TK - Trk

Bioactivity
Kinase	DRx	Metz
TRKA	inactive (10001nM)	inactive (>3162.28nM)
TRKB	inactive (10001nM)	inactive (>3981.07nM)
TRKC	inactive (10001nM)	inactive (>3162.28nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
STKR	12	10	1
RIPK	5	4	-
RAF	5	2	1
MLK	10	8	2
IRAK	4	3	2
LISK	4	3	1
LRRK	2	1	1

TKL - STKR

Bioactivity
Kinase	DRx	Metz
ALK2	inactive (10001nM)	inactive (>3981.07nM)
ALK4	inactive (10001nM)	-
ACTR2	inactive (10001nM)	-
ACTR2B	inactive (10001nM)	-
ALK1	inactive (10001nM)	-
BMPR1A	inactive (10001nM)	-
BMPR1B	inactive (10001nM)	-
BMPR2	inactive (10001nM)	-
TGFbR1	inactive (10001nM)	-
TGFbR2	inactive (10001nM)	-

TKL - RIPK

Bioactivity
Kinase	DRx	Metz
SgK288	inactive (10001nM)	-
RIPK1	inactive (10001nM)	-
RIPK2	inactive (10001nM)	-
ANKRD3	inactive (10001nM)	-

TKL - RAF

Bioactivity
Kinase	DRx	Metz
BRAF	inactive (10001nM)	-
RAF1	inactive (10001nM)	-

TKL - MLK

Bioactivity
Kinase	DRx	Metz
DLK	inactive (10001nM)	-
LZK	inactive (10001nM)	-
MLK1	active (1400nM)	-
MLK2	inactive (10001nM)	-
MLK3	inactive (10001nM)	-
TAK1	inactive (10001nM)	-
HH498	inactive (10001nM)	-
ZAK	inactive (10001nM)	-

TKL - IRAK

Bioactivity
Kinase	DRx	Metz
IRAK1	inactive (10001nM)	-
IRAK3	inactive (10001nM)	-
IRAK4	inactive (10001nM)	-

TKL - LISK

Bioactivity
Kinase	DRx	Metz
LIMK1	inactive (10001nM)	inactive (>3162.28nM)
LIMK2	inactive (10001nM)	-
TESK1	inactive (10001nM)	-

TKL - LRRK

Bioactivity
Kinase	DRx	Metz
LRRK2	inactive (10001nM)	inactive (>2511.89nM)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
ABC1	5	2	-
PIKK	6	1	-
RIO	3	3	-
Alpha	6	1	1

Atypical - ABC1

Bioactivity
Kinase	DRx	Metz
ADCK3	inactive (10001nM)	-
ADCK4	inactive (10001nM)	-

Atypical - PIKK

Bioactivity
Kinase	DRx	Metz
FRAP	inactive (10001nM)	-

Atypical - RIO

Bioactivity
Kinase	DRx	Metz
RIOK1	active (810nM)	-
RIOK2	inactive (10001nM)	-
RIOK3	active (650nM)	-

Atypical - Alpha

Bioactivity
Kinase	DRx	Metz
ChaK2	inactive (10001nM)	-
eEF2K	-	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
Akt	3	3	3
DMPK	7	7	3
GRK	7	3	1
NDR	4	4	-
MAST	5	1	-
PDK1	1	1	1
PKA	5	3	2
PKN	3	2	1
PKC	9	5	5
PKG	2	2	2
RSK	8	1	4
SGK	3	1	1
YANK	3	3	-

AGC - Akt

Bioactivity
Kinase	DRx	Metz
AKT1	inactive (10001nM)	-
AKT2	inactive (8700nM)	-
AKT3	active (1400nM)	-

AGC - DMPK

Bioactivity
Kinase	DRx	Metz
CRIK	active (1400nM)	-
DMPK1	active (280nM)	-
DMPK2	inactive (10001nM)	-
MRCKa	inactive (10001nM)	-
MRCKb	inactive (10001nM)	-
ROCK1	inactive (10001nM)	inactive (>3981.07nM)
ROCK2	inactive (10001nM)	-

AGC - GRK

Bioactivity
Kinase	DRx	Metz
RHOK	active (800nM)	-
GPRK4	active (590nM)	-
GPRK7	active (310nM)	-
GPRK5	-	inactive (3162.28nM)

AGC - NDR

Bioactivity
Kinase	DRx	Metz
LATS1	active (2600nM)	-
LATS2	active (640nM)	-
NDR1	inactive (10001nM)	-
NDR2	inactive (10001nM)	-

AGC - MAST

Bioactivity
Kinase	DRx	Metz
MAST1	inactive (10001nM)	-

AGC - PDK1

Bioactivity
Kinase	DRx	Metz
PDK1	active (700nM)	-

AGC - PKA

Bioactivity
Kinase	DRx	Metz
PKACa	inactive (5400nM)	active (630.96nM)
PKACb	inactive (3200nM)	-
PRKX	inactive (10001nM)	inactive (>3162.28nM)

AGC - PKN

Bioactivity
Kinase	DRx	Metz
PKN1	active (350nM)	-
PKN2	active (1500nM)	-

AGC - PKC

Bioactivity
Kinase	DRx	Metz
PKCd	active (3.6nM)	-
PKCe	active (11nM)	-
PKCh	active (1800nM)	-
PKCi	active (1400nM)	-
PKCt	active (2.5nM)	active (1.58nM)
PKCg	-	-
PKCz	-	-

AGC - PKG

Bioactivity
Kinase	DRx	Metz
PKG1	inactive (10001nM)	-
PKG2	inactive (3100nM)	-

AGC - RSK

Bioactivity
Kinase	DRx	Metz
p70S6K	active (210nM)	-
RSK2	-	active (19.95nM)
MSK1	-	-
MSK2	-	-

AGC - SGK

Bioactivity
Kinase	DRx	Metz
SGK3	active (1400nM)	-
SGK1	-	-

AGC - YANK

Bioactivity
Kinase	DRx	Metz
YANK1	inactive (10001nM)	-
YANK2	inactive (10001nM)	-
YANK3	inactive (10001nM)	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CAMKL	20	19	9
CAMK1	5	4	2
CAMK2	4	4	4
CASK	1	1	-
RAD53	1	1	1
DAPK	5	5	2
DCAMKL	3	3	1
MAPKAPK	5	4	4
MLCK	5	4	-
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
STK33	1	1	1
TSSK	5	1	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	Metz
AMPKa1	inactive (10001nM)	inactive (>3162.28nM)
AMPKa2	inactive (10001nM)	-
NuaK1	active (1800nM)	-
BRSK1	inactive (10001nM)	-
BRSK2	inactive (10001nM)	-
CHK1	active (540nM)	active (316.23nM)
HUNK	inactive (10001nM)	-
LKB1	inactive (5900nM)	-
MARK1	inactive (10001nM)	-
MARK2	inactive (10001nM)	-
MARK3	inactive (10001nM)	-
MARK4	inactive (10001nM)	-
MELK	inactive (10001nM)	-
NIM1	inactive (10001nM)	-
QSK	inactive (10001nM)	-
SIK	inactive (10001nM)	-
QIK	inactive (10001nM)	-
NuaK2	active (320nM)	-
SNRK	inactive (10001nM)	-
PASK	-	-

CAMK - CAMK1

Bioactivity
Kinase	DRx	Metz
CaMK1a	inactive (10001nM)	-
CaMK1d	inactive (4500nM)	inactive (>2511.89nM)
CaMK1g	inactive (10001nM)	-
CaMK4	inactive (10001nM)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	Metz
CaMK2a	inactive (4500nM)	inactive (>3981.07nM)
CaMK2b	inactive (10001nM)	-
CaMK2d	inactive (4600nM)	-
CaMK2g	inactive (7800nM)	-

CAMK - CASK

Bioactivity
Kinase	DRx	Metz
CASK	inactive (10001nM)	-

CAMK - RAD53

Bioactivity
Kinase	DRx	Metz
CHK2	inactive (3700nM)	-

CAMK - DAPK

Bioactivity
Kinase	DRx	Metz
DAPK1	active (970nM)	-
DAPK2	inactive (10001nM)	-
DAPK3	inactive (8000nM)	inactive (>5011.87nM)
DRAK1	inactive (10001nM)	-
DRAK2	inactive (10001nM)	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	Metz
DCLK1	inactive (10001nM)	-
DCLK2	inactive (10001nM)	-
DCLK3	inactive (10001nM)	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	Metz
MAPKAPK2	inactive (10001nM)	-
MAPKAPK5	inactive (10001nM)	-
MNK1	inactive (7100nM)	-
MNK2	inactive (10001nM)	-
MAPKAPK3	-	-

CAMK - MLCK

Bioactivity
Kinase	DRx	Metz
caMLCK	inactive (10001nM)	-
smMLCK	active (290nM)	-
skMLCK	inactive (10001nM)	-
SgK085	inactive (10001nM)	-

CAMK - PHK

Bioactivity
Kinase	DRx	Metz
PHKg1	inactive (3700nM)	-
PHKg2	inactive (10001nM)	-

CAMK - PIM

Bioactivity
Kinase	DRx	Metz
PIM1	active (270nM)	active (19.95nM)
PIM2	active (1700nM)	-
PIM3	active (12nM)	-

CAMK - PKD

Bioactivity
Kinase	DRx	Metz
PKD1	inactive (10001nM)	-
PKD2	active (890nM)	-
PKD3	inactive (10001nM)	inactive (>3981.07nM)

CAMK - STK33

Bioactivity
Kinase	DRx	Metz
STK33	active (2600nM)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	Metz
TSSK1	inactive (10001nM)	-
TSSK2	-	-

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
STE11	8	8	-
STE20	31	27	9
STE7	7	7	2

STE - STE11

Bioactivity
Kinase	DRx	Metz
MAP3K5	inactive (10001nM)	-
MAP3K6	inactive (10001nM)	-
MAP3K1	inactive (10001nM)	-
MAP3K7	inactive (10001nM)	-
MAP3K2	active (710nM)	-
MAP3K3	active (170nM)	-
MAP3K4	inactive (10001nM)	-
MAP3K8	active (48nM)	-

STE - STE20

Bioactivity
Kinase	DRx	Metz
HPK1	active (2600nM)	-
LOK	active (280nM)	-
GCK	active (290nM)	inactive (>2511.89nM)
KHS2	inactive (8400nM)	-
HGK	inactive (10001nM)	inactive (>5011.87nM)
KHS1	inactive (10001nM)	-
MINK	active (310nM)	-
MST1	inactive (10001nM)	-
MST2	active (960nM)	-
MST3	inactive (10001nM)	-
MST4	inactive (10001nM)	-
MYO3A	inactive (10001nM)	-
MYO3B	inactive (10001nM)	-
OSR1	inactive (10001nM)	-
PAK1	inactive (10001nM)	-
PAK2	inactive (10001nM)	-
PAK3	inactive (10001nM)	-
PAK4	inactive (10001nM)	inactive (>5011.87nM)
PAK6	inactive (10001nM)	-
PAK5	inactive (10001nM)	-
SLK	active (400nM)	-
STLK3	inactive (10001nM)	-
TAO1	active (1800nM)	inactive (2511.89nM)
TAO2	inactive (3900nM)	-
TAO3	active (97nM)	-
TNIK	inactive (10001nM)	-
YSK1	inactive (10001nM)	-

STE - STE7

Bioactivity
Kinase	DRx	Metz
MAP2K1	inactive (10001nM)	inactive (>3162.28nM)
MAP2K2	inactive (10001nM)	inactive (>3981.07nM)
MAP2K3	inactive (10001nM)	-
MAP2K4	active (930nM)	-
MAP2K5	active (1100nM)	-
MAP2K6	inactive (3900nM)	-
MAP2K7	inactive (10001nM)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CDK	20	8	7
CDKL	5	4	-
CLK	4	4	2
CK2	3	2	1
DYRK	10	8	6
MAPK	14	14	8
GSK	2	2	2
RCK	3	2	-
SRPK	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	Metz
PITSLRE	inactive (10001nM)	-
CHED	inactive (10001nM)	-
CDK11	inactive (10001nM)	-
PCTAIRE1	active (2600nM)	-
PCTAIRE2	inactive (10001nM)	-
PCTAIRE3	inactive (10001nM)	-
PFTAIRE2	inactive (10001nM)	-
PFTAIRE1	inactive (10001nM)	-
CDC2	-	-
CDK2	-	-
CDK5	-	inactive (>3162.28nM)
CDK8	-	inactive (>3981.07nM)
CDK7	-	inactive (2511.89nM)
CDK9	-	inactive (>1584.89nM)

CMGC - CDKL

Bioactivity
Kinase	DRx	Metz
CDKL1	inactive (10001nM)	-
CDKL2	inactive (10001nM)	-
CDKL3	inactive (10001nM)	-
CDKL5	inactive (4100nM)	-

CMGC - CLK

Bioactivity
Kinase	DRx	Metz
CLK1	active (910nM)	-
CLK2	active (420nM)	active (158.49nM)
CLK3	inactive (10001nM)	-
CLK4	active (1900nM)	active (125.89nM)

CMGC - CK2

Bioactivity
Kinase	DRx	Metz
CK2a1	inactive (10001nM)	-
CK2a2	inactive (6700nM)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	Metz
DYRK1A	active (250nM)	inactive (>1995.26nM)
DYRK1B	inactive (5400nM)	active (794.33nM)
DYRK2	inactive (10001nM)	-
HIPK1	active (230nM)	-
HIPK2	active (140nM)	-
HIPK3	active (77nM)	-
HIPK4	inactive (10001nM)	-
PRP4	active (1600nM)	-
DYRK3	-	-
DYRK4	-	-

CMGC - MAPK

Bioactivity
Kinase	DRx	Metz
Erk1	inactive (10001nM)	-
Erk2	inactive (10001nM)	-
Erk3	inactive (10001nM)	-
Erk4	inactive (10001nM)	-
Erk5	inactive (10001nM)	-
Erk7	active (88nM)	-
JNK1	inactive (10001nM)	inactive (>5011.87nM)
JNK2	inactive (10001nM)	inactive (>3981.07nM)
JNK3	inactive (10001nM)	-
NLK	inactive (10001nM)	-
p38a	inactive (10001nM)	inactive (>3981.07nM)
p38b	inactive (10001nM)	-
p38d	inactive (10001nM)	-
p38g	inactive (10001nM)	-

CMGC - GSK

Bioactivity
Kinase	DRx	Metz
GSK3A	inactive (10001nM)	inactive (1995.26nM)
GSK3B	active (2600nM)	active (794.33nM)

CMGC - RCK

Bioactivity
Kinase	DRx	Metz
ICK	active (240nM)	-
MAK	inactive (10001nM)	-

CMGC - SRPK

Bioactivity
Kinase	DRx	Metz
SRPK1	active (1200nM)	-
SRPK2	active (1100nM)	-
MSSK1	active (1600nM)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CK1	7	7	5
VRK	3	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	Metz
CK1a	inactive (10001nM)	inactive (>3981.07nM)
CK1a2	inactive (10001nM)	-
CK1d	inactive (10001nM)	-
CK1e	inactive (10001nM)	-
CK1g1	inactive (10001nM)	-
CK1g2	inactive (10001nM)	-
CK1g3	inactive (10001nM)	-

CK1 - VRK

Bioactivity
Kinase	DRx	Metz
VRK2	inactive (10001nM)	-