Compound Information


Test on : DRx

Compound Name : [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone

Inchikey : YYLKKYCXAOBSRM-UHFFFAOYSA-N

ChemSpider : 34233115

Pubchem CID : 67089852

ChEMBL : CHEMBL3184303




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

Other


Test Member No. in Family
Familyno. Member on 518kinaseDRx
44
33
22
42
21
44
119
33
44
11
32
21
54
22
11
Other - NAK

Bioactivity
KinaseDRx
AAK1active (48nM)
BIKEactive (9.6nM)
GAKactive (260nM)
MPSK1active (29nM)
Other - Aur

Bioactivity
KinaseDRx
AurAactive (650nM)
AurBactive (88nM)
AurCactive (59nM)
Other - CAMKK

Bioactivity
KinaseDRx
CaMKK1active (210nM)
CaMKK2active (470nM)
Other - PEK

Bioactivity
KinaseDRx
HRIinactive (10001nM)
PKRinactive (3600nM)
Other - IRE

Bioactivity
KinaseDRx
IRE1inactive (3500nM)
Other - IKK

Bioactivity
KinaseDRx
IKKaactive (180nM)
IKKbactive (430nM)
IKKeactive (340nM)
TBK1active (130nM)
Other - NEK

Bioactivity
KinaseDRx
NEK1inactive (3100nM)
NEK11inactive (10001nM)
NEK2inactive (5300nM)
NEK3active (1000nM)
NEK4active (1100nM)
NEK5active (2300nM)
NEK6active (120nM)
NEK7active (210nM)
NEK9active (520nM)
Other - WEE

Bioactivity
KinaseDRx
MYT1inactive (10001nM)
Wee1active (2800nM)
Wee1Binactive (4700nM)
Other - PLK

Bioactivity
KinaseDRx
PLK1inactive (10001nM)
PLK2inactive (10001nM)
PLK3inactive (10001nM)
PLK4active (21nM)
Other - SgK496

Bioactivity
KinaseDRx
SgK496active (660nM)
Other - NKF1

Bioactivity
KinaseDRx
SBKactive (580nM)
SgK110active (230nM)
Other - NKF4

Bioactivity
KinaseDRx
CLIK1active (630nM)
Other - ULK

Bioactivity
KinaseDRx
Fusedinactive (10001nM)
ULK1active (53nM)
ULK2active (130nM)
ULK3active (120nM)
Other - TLK

Bioactivity
KinaseDRx
TLK1active (2700nM)
TLK2active (1800nM)
Other - TTK

Bioactivity
KinaseDRx
TTKactive (110nM)

TK


Test Member No. in Family
Familyno. Member on 518kinaseDRx
22
22
33
1111
55
55
22
22
44
1413
22
22
44
33
33
44
22
11
11
11
22
22
22
33
TK - Abl

Bioactivity
KinaseDRx
ABL1active (63nM)
ABL2active (250nM)
TK - ALK

Bioactivity
KinaseDRx
ALKactive (660nM)
LTKactive (920nM)
TK - Axl

Bioactivity
KinaseDRx
AXLactive (180nM)
MERactive (750nM)
TYRO3inactive (10001nM)
TK - Src

Bioactivity
KinaseDRx
BLKinactive (3500nM)
BRKinactive (10001nM)
FGRactive (440nM)
FRKactive (2100nM)
FYNactive (660nM)
HCKinactive (4300nM)
LCKactive (1200nM)
LYNinactive (3100nM)
SRCactive (2800nM)
SRMactive (2700nM)
YESactive (18nM)
TK - Tec

Bioactivity
KinaseDRx
BMXactive (1900nM)
BTKactive (1000nM)
ITKactive (240nM)
TECinactive (10001nM)
TXKactive (580nM)
TK - PDGFR

Bioactivity
KinaseDRx
FMSactive (120nM)
FLT3active (15nM)
KITactive (53nM)
PDGFRaactive (130nM)
PDGFRbactive (30nM)
TK - Csk

Bioactivity
KinaseDRx
CSKinactive (4400nM)
CTKactive (3000nM)
TK - DDR

Bioactivity
KinaseDRx
DDR1inactive (3200nM)
DDR2active (2100nM)
TK - EGFR

Bioactivity
KinaseDRx
EGFRinactive (10001nM)
ErbB2inactive (10001nM)
ErbB3inactive (10001nM)
ErbB4inactive (10001nM)
TK - Eph

Bioactivity
KinaseDRx
EphA1active (150nM)
EphA2active (1500nM)
EphA3active (810nM)
EphA4inactive (10001nM)
EphA5inactive (10001nM)
EphA6active (1500nM)
EphA7active (390nM)
EphA8inactive (10001nM)
EphB1active (2500nM)
EphB2inactive (10001nM)
EphB3inactive (10001nM)
EphB4active (2900nM)
EphB6active (130nM)
TK - FAK

Bioactivity
KinaseDRx
FAKactive (2100nM)
PYK2active (760nM)
TK - Fer

Bioactivity
KinaseDRx
FERactive (1100nM)
FESactive (750nM)
TK - FGFR

Bioactivity
KinaseDRx
FGFR1active (370nM)
FGFR2active (850nM)
FGFR3active (1200nM)
FGFR4active (2300nM)
TK - VEGFR

Bioactivity
KinaseDRx
FLT1active (73nM)
FLT4active (1300nM)
KDRactive (120nM)
TK - InsR

Bioactivity
KinaseDRx
IGF1Ractive (920nM)
INSRactive (400nM)
IRRactive (420nM)
TK - JakA

Bioactivity
KinaseDRx
JAK1active (1200nM)
JAK2active (76nM)
JAK3active (39nM)
TYK2active (160nM)
TK - Met

Bioactivity
KinaseDRx
METactive (170nM)
RONactive (810nM)
TK - Musk

Bioactivity
KinaseDRx
MUSKactive (200nM)
TK - Ret

Bioactivity
KinaseDRx
RETactive (150nM)
TK - Sev

Bioactivity
KinaseDRx
ROSinactive (10001nM)
TK - Syk

Bioactivity
KinaseDRx
SYKactive (670nM)
ZAP70active (940nM)
TK - Tie

Bioactivity
KinaseDRx
TIE1active (300nM)
TIE2active (1100nM)
TK - Ack

Bioactivity
KinaseDRx
TNK1active (580nM)
ACKactive (1600nM)
TK - Trk

Bioactivity
KinaseDRx
TRKAactive (270nM)
TRKBactive (140nM)
TRKCactive (250nM)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseDRx
1210
54
52
108
43
43
21
TKL - STKR

Bioactivity
KinaseDRx
ALK2active (140nM)
ALK4inactive (10001nM)
ACTR2active (320nM)
ACTR2Bactive (370nM)
ALK1inactive (10001nM)
BMPR1Aactive (1900nM)
BMPR1Bactive (120nM)
BMPR2active (370nM)
TGFbR1inactive (10001nM)
TGFbR2inactive (10001nM)
TKL - RIPK

Bioactivity
KinaseDRx
SgK288active (82nM)
RIPK1active (64nM)
RIPK2inactive (3700nM)
ANKRD3active (130nM)
TKL - RAF

Bioactivity
KinaseDRx
BRAFinactive (10001nM)
RAF1inactive (10001nM)
TKL - MLK

Bioactivity
KinaseDRx
DLKactive (67nM)
LZKactive (500nM)
MLK1active (650nM)
MLK2active (1500nM)
MLK3active (230nM)
TAK1active (36nM)
HH498inactive (10001nM)
ZAKactive (580nM)
TKL - IRAK

Bioactivity
KinaseDRx
IRAK1active (48nM)
IRAK3active (240nM)
IRAK4active (680nM)
TKL - LISK

Bioactivity
KinaseDRx
LIMK1inactive (10001nM)
LIMK2inactive (10001nM)
TESK1inactive (10001nM)
TKL - LRRK

Bioactivity
KinaseDRx
LRRK2active (350nM)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseDRx
52
61
33
61
Atypical - ABC1

Bioactivity
KinaseDRx
ADCK3inactive (10001nM)
ADCK4inactive (10001nM)
Atypical - PIKK

Bioactivity
KinaseDRx
FRAPinactive (10001nM)
Atypical - RIO

Bioactivity
KinaseDRx
RIOK1active (47nM)
RIOK2inactive (5000nM)
RIOK3active (61nM)
Atypical - Alpha

Bioactivity
KinaseDRx
ChaK2inactive (10001nM)

AGC


Test Member No. in Family
Familyno. Member on 518kinaseDRx
33
77
73
44
51
11
53
32
95
22
81
31
33
AGC - Akt

Bioactivity
KinaseDRx
AKT1inactive (10001nM)
AKT2inactive (10001nM)
AKT3inactive (10001nM)
AGC - DMPK

Bioactivity
KinaseDRx
CRIKactive (650nM)
DMPK1inactive (3800nM)
DMPK2active (2100nM)
MRCKainactive (10001nM)
MRCKbinactive (10001nM)
ROCK1active (300nM)
ROCK2active (250nM)
AGC - GRK

Bioactivity
KinaseDRx
RHOKinactive (10001nM)
GPRK4active (71nM)
GPRK7inactive (5000nM)
AGC - NDR

Bioactivity
KinaseDRx
LATS1inactive (5000nM)
LATS2active (1500nM)
NDR1active (390nM)
NDR2active (1100nM)
AGC - MAST

Bioactivity
KinaseDRx
MAST1inactive (10001nM)
AGC - PDK1

Bioactivity
KinaseDRx
PDK1active (650nM)
AGC - PKA

Bioactivity
KinaseDRx
PKACainactive (10001nM)
PKACbinactive (10001nM)
PRKXactive (1200nM)
AGC - PKN

Bioactivity
KinaseDRx
PKN1active (580nM)
PKN2active (880nM)
AGC - PKC

Bioactivity
KinaseDRx
PKCdinactive (10001nM)
PKCeinactive (10001nM)
PKChinactive (10001nM)
PKCiinactive (10001nM)
PKCtinactive (10001nM)
AGC - PKG

Bioactivity
KinaseDRx
PKG1active (2500nM)
PKG2active (800nM)
AGC - RSK

Bioactivity
KinaseDRx
p70S6Kactive (310nM)
AGC - SGK

Bioactivity
KinaseDRx
SGK3active (96nM)
AGC - YANK

Bioactivity
KinaseDRx
YANK1inactive (4400nM)
YANK2inactive (10001nM)
YANK3inactive (10001nM)

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseDRx
2019
54
44
11
11
55
33
54
54
22
33
33
11
51
CAMK - CAMKL

Bioactivity
KinaseDRx
AMPKa1active (430nM)
AMPKa2active (440nM)
NuaK1inactive (10001nM)
BRSK1active (1900nM)
BRSK2active (1200nM)
CHK1active (710nM)
HUNKactive (460nM)
LKB1active (240nM)
MARK1active (310nM)
MARK2active (440nM)
MARK3active (1300nM)
MARK4active (210nM)
MELKactive (210nM)
NIM1active (1100nM)
QSKactive (2300nM)
SIKactive (670nM)
QIKactive (560nM)
NuaK2active (54nM)
SNRKinactive (10001nM)
CAMK - CAMK1

Bioactivity
KinaseDRx
CaMK1aactive (1400nM)
CaMK1dactive (530nM)
CaMK1gactive (2100nM)
CaMK4inactive (10001nM)
CAMK - CAMK2

Bioactivity
KinaseDRx
CaMK2ainactive (4000nM)
CaMK2binactive (10001nM)
CaMK2dinactive (10001nM)
CaMK2ginactive (10001nM)
CAMK - CASK

Bioactivity
KinaseDRx
CASKinactive (10001nM)
CAMK - RAD53

Bioactivity
KinaseDRx
CHK2active (95nM)
CAMK - DAPK

Bioactivity
KinaseDRx
DAPK1active (360nM)
DAPK2active (1800nM)
DAPK3active (310nM)
DRAK1active (2.9nM)
DRAK2active (4.8nM)
CAMK - DCAMKL

Bioactivity
KinaseDRx
DCLK1active (2000nM)
DCLK2inactive (10001nM)
DCLK3active (86nM)
CAMK - MAPKAPK

Bioactivity
KinaseDRx
MAPKAPK2inactive (10001nM)
MAPKAPK5active (1200nM)
MNK1inactive (10001nM)
MNK2active (1200nM)
CAMK - MLCK

Bioactivity
KinaseDRx
caMLCKactive (4.3nM)
smMLCKactive (740nM)
skMLCKactive (52nM)
SgK085active (170nM)
CAMK - PHK

Bioactivity
KinaseDRx
PHKg1active (210nM)
PHKg2active (140nM)
CAMK - PIM

Bioactivity
KinaseDRx
PIM1inactive (10001nM)
PIM2inactive (10001nM)
PIM3inactive (10001nM)
CAMK - PKD

Bioactivity
KinaseDRx
PKD1active (1200nM)
PKD2active (1500nM)
PKD3active (780nM)
CAMK - STK33

Bioactivity
KinaseDRx
STK33active (140nM)
CAMK - TSSK

Bioactivity
KinaseDRx
TSSK1active (2300nM)

STE


Test Member No. in Family
Familyno. Member on 518kinaseDRx
88
3127
77
STE - STE11

Bioactivity
KinaseDRx
MAP3K5inactive (10001nM)
MAP3K6inactive (10001nM)
MAP3K1inactive (10001nM)
MAP3K7inactive (10001nM)
MAP3K2active (72nM)
MAP3K3active (120nM)
MAP3K4active (1600nM)
MAP3K8active (5.2nM)
STE - STE20

Bioactivity
KinaseDRx
HPK1active (63nM)
LOKactive (13nM)
GCKactive (11nM)
KHS2active (150nM)
HGKactive (33nM)
KHS1active (260nM)
MINKactive (25nM)
MST1active (560nM)
MST2inactive (10001nM)
MST3active (1100nM)
MST4active (1100nM)
MYO3Aactive (740nM)
MYO3Binactive (6000nM)
OSR1active (1700nM)
PAK1active (2100nM)
PAK2active (2700nM)
PAK3active (460nM)
PAK4active (1500nM)
PAK6active (1300nM)
PAK5active (390nM)
SLKactive (13nM)
STLK3active (890nM)
TAO1active (1800nM)
TAO2inactive (10001nM)
TAO3active (1000nM)
TNIKactive (28nM)
YSK1inactive (4300nM)
STE - STE7

Bioactivity
KinaseDRx
MAP2K1active (530nM)
MAP2K2active (850nM)
MAP2K3active (150nM)
MAP2K4active (250nM)
MAP2K5active (120nM)
MAP2K6active (820nM)
MAP2K7inactive (10001nM)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseDRx
208
54
44
32
108
1414
22
32
33
CMGC - CDK

Bioactivity
KinaseDRx
PITSLREinactive (10001nM)
CHEDinactive (10001nM)
CDK11inactive (10001nM)
PCTAIRE1active (830nM)
PCTAIRE2active (1900nM)
PCTAIRE3inactive (10001nM)
PFTAIRE2active (2600nM)
PFTAIRE1active (870nM)
CMGC - CDKL

Bioactivity
KinaseDRx
CDKL1inactive (10001nM)
CDKL2active (1400nM)
CDKL3inactive (10001nM)
CDKL5inactive (10001nM)
CMGC - CLK

Bioactivity
KinaseDRx
CLK1active (64nM)
CLK2active (93nM)
CLK3inactive (6200nM)
CLK4active (49nM)
CMGC - CK2

Bioactivity
KinaseDRx
CK2a1active (1200nM)
CK2a2active (230nM)
CMGC - DYRK

Bioactivity
KinaseDRx
DYRK1Aactive (180nM)
DYRK1Bactive (940nM)
DYRK2active (390nM)
HIPK1active (430nM)
HIPK2active (300nM)
HIPK3active (580nM)
HIPK4active (1000nM)
PRP4active (270nM)
CMGC - MAPK

Bioactivity
KinaseDRx
Erk1inactive (10001nM)
Erk2inactive (10001nM)
Erk3inactive (5500nM)
Erk4inactive (10001nM)
Erk5active (2700nM)
Erk7active (1100nM)
JNK1active (580nM)
JNK2active (230nM)
JNK3active (51nM)
NLKinactive (10001nM)
p38ainactive (10001nM)
p38bactive (1400nM)
p38dinactive (10001nM)
p38ginactive (10001nM)
CMGC - GSK

Bioactivity
KinaseDRx
GSK3Ainactive (10001nM)
GSK3Binactive (10001nM)
CMGC - RCK

Bioactivity
KinaseDRx
ICKactive (2200nM)
MAKinactive (10001nM)
CMGC - SRPK

Bioactivity
KinaseDRx
SRPK1active (55nM)
SRPK2active (15nM)
MSSK1active (200nM)

CK1


Test Member No. in Family
Familyno. Member on 518kinaseDRx
77
31
CK1 - CK1

Bioactivity
KinaseDRx
CK1aactive (1200nM)
CK1a2inactive (10001nM)
CK1dactive (2300nM)
CK1eactive (630nM)
CK1g1active (1200nM)
CK1g2active (580nM)
CK1g3active (1200nM)
CK1 - VRK

Bioactivity
KinaseDRx
VRK2inactive (10001nM)