Compound Information
Test on : GPCR
Compound Name : SB-409514
Inchikey : YYGKSMKAYKZSBC-UHFFFAOYSA-N
ChemSpider : 5021944
Pubchem CID : 6539478
ChEMBL : CHEMBL160333
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (7.81%) |
TYK2 | inactive (20.04%) |
JAK2 | inactive (2.24%) |
JAK3 | active (51.44%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.56%) |
FES | inactive (1.14%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (7.89%) |
ABL2 | inactive (8.28%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-5.59%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (1.46%) |
BTK | inactive (1.57%) |
TXK | inactive (3.52%) |
TEC | inactive (1.44%) |
ITK | inactive (1.28%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (-2.04%) |
SRM | inactive (-1.95%) |
FRK | inactive (1.74%) |
BLK | inactive (5.96%) |
LCK | inactive (6.56%) |
HCK | inactive (3.34%) |
FGR | inactive (3.74%) |
FYN | inactive (2.24%) |
SRC | inactive (5.62%) |
YES | inactive (2.76%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.32%) |
EphA4 | inactive (-8.81%) |
EphA3 | inactive (-2.04%) |
EphB4 | inactive (-0.03%) |
EphB3 | inactive (-5.14%) |
EphB2 | inactive (-8.35%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (9.11%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.79%) |
ZAP70 | inactive (2.74%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (0.35%) |
ALK | inactive (4.45%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (7.24%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (6.7%) |
IGF1R | inactive (2.43%) |
IRR | inactive (0.03%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (-1.13%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (2.41%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.57%) |
TRKB | inactive (0.31%) |
TRKC | inactive (1.68%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (6%) |
MET | inactive (3.7%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-0.83%) |
MER | inactive (3.08%) |
TYRO3 | inactive (0.29%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (7.66%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (6.97%) |
FGFR2 | inactive (32.48%) |
FGFR3 | inactive (21.31%) |
FGFR4 | inactive (2.43%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.36%) |
KDR | inactive (20.1%) |
FLT4 | inactive (13.3%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (46.82%) |
KIT | inactive (-2.75%) |
FLT3 | inactive (0.95%) |
PDGFRa | inactive (15.12%) |
PDGFRb | inactive (11.46%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.61%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-0.58%) |
TNK1 | inactive (8.8%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.12%) |
ErbB2 | inactive (-5.89%) |
ErbB4 | inactive (6.06%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.96%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (21.31%) |
MST1 | active (75.19%) |
MST2 | active (66.75%) |
MST4 | inactive (11.24%) |
HGK | inactive (7.19%) |
MINK | inactive (7.79%) |
LOK | inactive (46.33%) |
PAK1 | inactive (4.48%) |
PAK3 | inactive (1.4%) |
PAK2 | inactive (-0.45%) |
PAK5 | inactive (-13.12%) |
PAK6 | inactive (-3.45%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (7.65%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (9.44%) |
CK1g2 | inactive (0.54%) |
CK1g1 | inactive (1.3%) |
CK1g3 | inactive (0.9%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.21%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (6.09%) |
AurC | inactive (13.14%) |
AurA | inactive (11.05%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.17%) |
NEK2 | inactive (1.51%) |
NEK9 | inactive (8.97%) |
NEK7 | inactive (1.51%) |
NEK6 | inactive (-3.08%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (23.89%) |
IKKe | inactive (0.33%) |
IKKb | inactive (-3.39%) |
IKKa | inactive (0.73%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (4.84%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (6.41%) |
GPRK6 | inactive (1%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (5.12%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (2.04%) |
MSK2 | inactive (3.61%) |
RSK1 | inactive (7.59%) |
RSK2 | inactive (14.09%) |
RSK4 | inactive (21.47%) |
RSK3 | inactive (19.76%) |
p70S6K | inactive (0.8%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.16%) |
AKT1 | inactive (1.25%) |
AKT3 | inactive (0.23%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (0.01%) |
SGK3 | inactive (-0.88%) |
SGK2 | inactive (3.67%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.97%) |
PKCg | inactive (0.01%) |
PKCa | inactive (6.33%) |
PKCt | inactive (4.79%) |
PKCi | inactive (0.5%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.33%) |
PKG1 | inactive (2.21%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-1.53%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (0.49%) |
ROCK2 | inactive (-2.05%) |
MRCKb | inactive (2.02%) |
MRCKa | inactive (3.73%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (2.07%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.92%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (4.94%) |
CaMK1d | inactive (5.88%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.07%) |
PHKg2 | inactive (-1.03%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (12%) |
CaMK2a | inactive (6.43%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.79%) |
MAPKAPK2 | inactive (0.04%) |
MAPKAPK3 | inactive (1.59%) |
MNK2 | inactive (1.96%) |
MNK1 | inactive (7.25%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (1.47%) |
PKD1 | inactive (1.38%) |
PKD2 | inactive (3.16%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (17.3%) |
MARK3 | inactive (18.56%) |
MARK1 | inactive (15.6%) |
QIK | inactive (19.82%) |
SIK | inactive (9.22%) |
NuaK1 | inactive (48.34%) |
BRSK1 | inactive (12.94%) |
BRSK2 | inactive (18.99%) |
MELK | inactive (6.85%) |
CHK1 | inactive (4.63%) |
PASK | inactive (0.49%) |
AMPKa1 | inactive (8.5%) |
AMPKa2 | inactive (11.04%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.16%) |
TSSK1 | inactive (1.63%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.13%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.76%) |
PIM3 | inactive (0.87%) |
PIM1 | inactive (3.87%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (1.38%) |
p38a | inactive (8.66%) |
p38b | inactive (4.99%) |
p38d | inactive (0.3%) |
Erk2 | inactive (1.91%) |
Erk1 | inactive (2.28%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (71.27%) |
GSK3B | active (65.07%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-4.83%) |
MSSK1 | inactive (2.47%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (5.01%) |
CLK2 | inactive (26.06%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (1.28%) |
HIPK4 | inactive (0.62%) |
DYRK1B | inactive (8.29%) |
DYRK1A | inactive (17.27%) |
DYRK2 | inactive (0.69%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (-1.28%) |