Compound Information
Test on : GPCR
Compound Name : GSK2163632A
Inchikey : YNSCKPCDFIDINW-UHFFFAOYSA-N
ChemSpider : 24691698
Pubchem CID : 25210972
ChEMBL : CHEMBL463931
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (2.78%) |
TYK2 | inactive (-1.34%) |
JAK2 | inactive (0.03%) |
JAK3 | inactive (1.42%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | active (94.78%) |
FES | active (79.44%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (6.2%) |
ABL2 | inactive (4.17%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (0.65%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (5.73%) |
BTK | inactive (1.1%) |
TXK | inactive (4.22%) |
TEC | inactive (8.93%) |
ITK | inactive (3.88%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (19.21%) |
SRM | inactive (-3.22%) |
FRK | inactive (8.45%) |
BLK | inactive (6.26%) |
LCK | inactive (4.76%) |
HCK | inactive (12.92%) |
FGR | inactive (6.75%) |
FYN | inactive (1.15%) |
SRC | inactive (11.72%) |
YES | inactive (0.61%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.81%) |
EphA4 | inactive (6.49%) |
EphA3 | inactive (4.34%) |
EphB4 | inactive (2.72%) |
EphB3 | inactive (-7.19%) |
EphB2 | inactive (9.01%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (96.74%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (4.93%) |
ZAP70 | inactive (14.88%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | active (96.28%) |
ALK | active (78.54%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (83.07%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (97.99%) |
IGF1R | active (97.14%) |
IRR | active (97.94%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.72%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | active (62.37%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (13.59%) |
TRKB | inactive (11.37%) |
TRKC | inactive (11.58%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (28.92%) |
MET | inactive (23.07%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | active (85.53%) |
MER | inactive (16.06%) |
TYRO3 | inactive (18.6%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (14.07%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (4.2%) |
FGFR2 | inactive (13.52%) |
FGFR3 | inactive (7.81%) |
FGFR4 | inactive (4.78%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.83%) |
KDR | inactive (14.06%) |
FLT4 | inactive (5.12%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (94.26%) |
KIT | active (67.57%) |
FLT3 | inactive (12.96%) |
PDGFRa | active (63.2%) |
PDGFRb | active (62.66%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.63%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (43.45%) |
TNK1 | active (89.26%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (9.19%) |
ErbB2 | inactive (-0.07%) |
ErbB4 | inactive (36.35%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.28%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (14.86%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (22.64%) |
MST1 | inactive (47.68%) |
MST2 | inactive (22.08%) |
MST4 | inactive (0.56%) |
HGK | inactive (14.76%) |
MINK | inactive (15.27%) |
LOK | inactive (17.32%) |
PAK1 | inactive (7.09%) |
PAK3 | inactive (5.85%) |
PAK2 | inactive (3.48%) |
PAK5 | inactive (-3.07%) |
PAK6 | inactive (3.1%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (12.29%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (14.86%) |
CK1g2 | inactive (20.56%) |
CK1g1 | inactive (21.14%) |
CK1g3 | inactive (24.29%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | active (89.39%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (11.69%) |
AurC | inactive (13.68%) |
AurA | inactive (13.15%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.8%) |
NEK2 | inactive (7.22%) |
NEK9 | inactive (9.86%) |
NEK7 | inactive (42.07%) |
NEK6 | inactive (5.27%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | active (50.71%) |
IKKe | inactive (35.23%) |
IKKb | inactive (6.07%) |
IKKa | inactive (0.27%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (49.64%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | active (63.16%) |
GPRK6 | active (87.15%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (14.03%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (8.3%) |
MSK2 | inactive (13.85%) |
RSK1 | active (65.96%) |
RSK2 | active (50.7%) |
RSK4 | inactive (49.58%) |
RSK3 | inactive (34.37%) |
p70S6K | inactive (4.93%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.14%) |
AKT1 | inactive (0.48%) |
AKT3 | inactive (2.54%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.59%) |
SGK3 | inactive (4.25%) |
SGK2 | inactive (2.79%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (9.1%) |
PKCg | inactive (44.02%) |
PKCa | inactive (34.32%) |
PKCt | inactive (16.19%) |
PKCi | inactive (5.01%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (9.54%) |
PKG1 | inactive (8.75%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (6.05%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | active (66.55%) |
ROCK2 | active (72.08%) |
MRCKb | inactive (14.86%) |
MRCKa | inactive (6.74%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (21.07%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (5.94%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (19.88%) |
CaMK1d | inactive (30.79%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | active (62%) |
PHKg2 | inactive (6.91%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (25.68%) |
CaMK2a | inactive (10.48%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (3.7%) |
MAPKAPK2 | inactive (-0.86%) |
MAPKAPK3 | inactive (-0.02%) |
MNK2 | inactive (3.03%) |
MNK1 | inactive (6.26%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | active (75.67%) |
PKD1 | active (58.46%) |
PKD2 | active (75.72%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (6.44%) |
MARK3 | inactive (7.59%) |
MARK1 | inactive (11.89%) |
QIK | inactive (7.78%) |
SIK | inactive (7.92%) |
NuaK1 | inactive (9.13%) |
BRSK1 | inactive (6.36%) |
BRSK2 | inactive (4.71%) |
MELK | inactive (14.84%) |
CHK1 | inactive (-2.52%) |
PASK | inactive (-1.18%) |
AMPKa1 | inactive (7.07%) |
AMPKa2 | inactive (7.54%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | active (94.56%) |
TSSK1 | active (96.29%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (5.25%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (11.95%) |
PIM3 | active (68.08%) |
PIM1 | active (93.27%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (13.91%) |
p38a | inactive (10.69%) |
p38b | inactive (8.81%) |
p38d | inactive (9.12%) |
Erk2 | inactive (12.16%) |
Erk1 | inactive (3.62%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (21.07%) |
GSK3B | inactive (16.98%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (15.78%) |
MSSK1 | inactive (3.51%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (4.74%) |
CLK2 | active (79.48%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (7.66%) |
HIPK4 | inactive (6.13%) |
DYRK1B | inactive (10.21%) |
DYRK1A | inactive (15.47%) |
DYRK2 | inactive (6.57%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | active (75.31%) |