Compound Information
Test on : GPCR
Compound Name : GSK1007102B
Inchikey : YESZPTXRITXXAP-LMOVPXPDSA-N
ChemSpider : 28484241
Pubchem CID : 56604034
ChEMBL : CHEMBL1909349
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (4.4%) |
TYK2 | inactive (1.49%) |
JAK2 | inactive (0.78%) |
JAK3 | inactive (3.54%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (11.59%) |
FES | inactive (5.21%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (5.55%) |
ABL2 | inactive (6.91%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-5.08%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (-1.16%) |
BTK | inactive (-0.15%) |
TXK | inactive (2.31%) |
TEC | inactive (5.82%) |
ITK | inactive (0.91%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (-2.85%) |
SRM | inactive (0.15%) |
FRK | inactive (0.63%) |
BLK | inactive (10.05%) |
LCK | inactive (4.58%) |
HCK | inactive (14.14%) |
FGR | inactive (28.63%) |
FYN | inactive (25%) |
SRC | inactive (20.9%) |
YES | inactive (23.82%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-4.53%) |
EphA4 | inactive (-4.76%) |
EphA3 | inactive (-0.7%) |
EphB4 | inactive (1.16%) |
EphB3 | inactive (-3.07%) |
EphB2 | inactive (-10.4%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (80.14%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.56%) |
ZAP70 | inactive (1.24%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | active (76.58%) |
ALK | inactive (19.62%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (11.08%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.91%) |
IGF1R | inactive (-0.35%) |
IRR | inactive (-2.16%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (0.1%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (1.93%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (0.16%) |
TRKB | inactive (1.16%) |
TRKC | inactive (0.7%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (3.42%) |
MET | inactive (-0.12%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (8.92%) |
MER | inactive (0.57%) |
TYRO3 | inactive (6.97%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (90.03%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (6.16%) |
FGFR2 | inactive (1.12%) |
FGFR3 | inactive (-0.33%) |
FGFR4 | inactive (1.13%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (79.76%) |
KDR | active (75.36%) |
FLT4 | active (93.81%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (1.9%) |
KIT | inactive (2.69%) |
FLT3 | inactive (-0.29%) |
PDGFRa | active (70.5%) |
PDGFRb | active (79.55%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (11.39%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-1.74%) |
TNK1 | inactive (-3.26%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (7.41%) |
ErbB2 | inactive (-2.4%) |
ErbB4 | inactive (3.97%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (-0.97%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.48%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (24.78%) |
MST1 | inactive (15.95%) |
MST2 | inactive (-24.5%) |
MST4 | inactive (10.8%) |
HGK | inactive (20.4%) |
MINK | inactive (11%) |
LOK | inactive (19.75%) |
PAK1 | inactive (13.97%) |
PAK3 | inactive (15.6%) |
PAK2 | inactive (48.93%) |
PAK5 | active (62.23%) |
PAK6 | active (67.59%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (6.28%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.15%) |
CK1g2 | inactive (4.43%) |
CK1g1 | inactive (7.01%) |
CK1g3 | inactive (9.88%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.24%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (6.56%) |
AurC | inactive (1.38%) |
AurA | inactive (5.65%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (17.23%) |
NEK2 | inactive (33.49%) |
NEK9 | inactive (-1.03%) |
NEK7 | inactive (0.58%) |
NEK6 | inactive (-0.92%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | active (67.96%) |
IKKe | active (98.87%) |
IKKb | inactive (-3.23%) |
IKKa | inactive (-2.27%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (8.72%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | active (113.79%) |
GPRK6 | inactive (1.51%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (27.81%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | active (51.31%) |
MSK2 | active (61.31%) |
RSK1 | active (71.6%) |
RSK2 | active (69.47%) |
RSK4 | inactive (23.4%) |
RSK3 | active (69.86%) |
p70S6K | active (58.4%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | active (96.15%) |
AKT1 | active (96.39%) |
AKT3 | active (94.95%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (34.16%) |
SGK3 | active (94.21%) |
SGK2 | inactive (3.43%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | active (99.03%) |
PKCg | active (81.14%) |
PKCa | active (69.69%) |
PKCt | active (84.79%) |
PKCi | inactive (26.39%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | active (84.42%) |
PKG1 | active (81.14%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | active (88.15%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | active (51.72%) |
ROCK2 | active (59.44%) |
MRCKb | active (66.16%) |
MRCKa | active (72.78%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (26.73%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (18.51%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (4.51%) |
CaMK1d | inactive (29.44%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (12.34%) |
PHKg2 | inactive (-0.93%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (14.33%) |
CaMK2a | inactive (1.68%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-1.11%) |
MAPKAPK2 | inactive (-1%) |
MAPKAPK3 | inactive (-0.47%) |
MNK2 | inactive (33.12%) |
MNK1 | inactive (6.37%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | active (64.35%) |
PKD1 | active (61.64%) |
PKD2 | active (66.28%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | active (90.73%) |
MARK3 | active (101.34%) |
MARK1 | active (93.14%) |
QIK | inactive (14.82%) |
SIK | inactive (8.3%) |
NuaK1 | active (69.58%) |
BRSK1 | inactive (38.4%) |
BRSK2 | active (58.84%) |
MELK | active (90.41%) |
CHK1 | inactive (31.05%) |
PASK | inactive (15.87%) |
AMPKa1 | active (88.09%) |
AMPKa2 | active (68.09%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (14.79%) |
TSSK1 | active (95.61%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.31%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (20.65%) |
PIM3 | inactive (39%) |
PIM1 | inactive (35.22%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (1.01%) |
p38a | inactive (1.33%) |
p38b | inactive (2.96%) |
p38d | inactive (0.11%) |
Erk2 | inactive (5.15%) |
Erk1 | inactive (0.99%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (86.12%) |
GSK3B | active (84.6%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.25%) |
MSSK1 | inactive (-2.07%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.71%) |
CLK2 | active (56.31%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (55.3%) |
HIPK4 | inactive (36.28%) |
DYRK1B | inactive (9.96%) |
DYRK1A | inactive (7.95%) |
DYRK2 | inactive (0.08%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.9%) |