Compound Information
Test on : GPCR
Compound Name : CHEMBL187985
Inchikey : XXTCPTVXBKEROM-UHFFFAOYSA-N
ChemSpider : 23253092
Pubchem CID : 44397201
ChEMBL : CHEMBL187985
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-2.79%) |
TYK2 | inactive (4.26%) |
JAK2 | inactive (-1.59%) |
JAK3 | inactive (2.23%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (2.34%) |
FES | inactive (-3.78%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (0.66%) |
ABL2 | inactive (7.36%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-3.39%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (-1.4%) |
BTK | inactive (-1.53%) |
TXK | inactive (-2.21%) |
TEC | inactive (-3.76%) |
ITK | inactive (-0.14%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (-2.02%) |
SRM | inactive (0.26%) |
FRK | - |
BLK | inactive (-2.43%) |
LCK | inactive (-0.36%) |
HCK | inactive (2.43%) |
FGR | inactive (-0.02%) |
FYN | inactive (0.7%) |
SRC | inactive (-2.52%) |
YES | inactive (4.6%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-4.35%) |
EphA4 | inactive (-8.11%) |
EphA3 | inactive (-2.29%) |
EphB4 | inactive (-1.17%) |
EphB3 | inactive (-3.63%) |
EphB2 | inactive (-2.7%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (-3.88%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (2.9%) |
ZAP70 | inactive (2.3%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (-0.6%) |
ALK | inactive (-2.28%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (4.49%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (-1.23%) |
IGF1R | inactive (2.72%) |
IRR | inactive (-0.91%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.39%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.11%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (0.75%) |
TRKB | inactive (0.49%) |
TRKC | inactive (-0.34%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (0.95%) |
MET | inactive (-1.91%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (4.04%) |
MER | inactive (1.56%) |
TYRO3 | inactive (-1.5%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (20.81%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-1.9%) |
FGFR2 | inactive (-1.03%) |
FGFR3 | inactive (-0.31%) |
FGFR4 | inactive (-0.48%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (-0.61%) |
KDR | inactive (6.67%) |
FLT4 | inactive (3.38%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (0.02%) |
KIT | inactive (1.81%) |
FLT3 | inactive (-2%) |
PDGFRa | inactive (6.63%) |
PDGFRb | inactive (8.55%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (0.05%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (-0.6%) |
TNK1 | inactive (-3.3%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (13.03%) |
ErbB2 | inactive (-0.23%) |
ErbB4 | inactive (-2.19%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (-0.28%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (4.02%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (4.2%) |
MST1 | inactive (-1.2%) |
MST2 | inactive (0.3%) |
MST4 | inactive (0.92%) |
HGK | inactive (2.78%) |
MINK | inactive (2.4%) |
LOK | inactive (2.42%) |
PAK1 | inactive (-4.47%) |
PAK3 | inactive (-1.25%) |
PAK2 | inactive (-1.78%) |
PAK5 | inactive (-17.14%) |
PAK6 | inactive (0.23%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (-2.11%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (0.23%) |
CK1g2 | inactive (-0.7%) |
CK1g1 | inactive (-0.83%) |
CK1g3 | inactive (-0.62%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (-0.08%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (5.43%) |
AurC | inactive (-2.42%) |
AurA | inactive (2.53%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.27%) |
NEK2 | inactive (-0.91%) |
NEK9 | inactive (1.67%) |
NEK7 | inactive (-1.35%) |
NEK6 | inactive (-1.63%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.54%) |
IKKe | inactive (-2.89%) |
IKKb | inactive (-0.76%) |
IKKa | inactive (5.88%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (-1.76%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (0.27%) |
GPRK6 | inactive (2.71%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (-3.43%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (11.21%) |
MSK2 | inactive (3.67%) |
RSK1 | inactive (7.82%) |
RSK2 | inactive (4.5%) |
RSK4 | inactive (-0.13%) |
RSK3 | inactive (7.05%) |
p70S6K | inactive (8.23%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-0.45%) |
AKT1 | inactive (-2.19%) |
AKT3 | inactive (1.15%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (-1.03%) |
SGK3 | inactive (-0.02%) |
SGK2 | inactive (2.83%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (11.17%) |
PKCg | inactive (2.66%) |
PKCa | inactive (0.84%) |
PKCt | inactive (0.44%) |
PKCi | inactive (-0.25%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (9.26%) |
PKG1 | inactive (3.63%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.74%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (22.2%) |
ROCK2 | inactive (30.65%) |
MRCKb | inactive (2.55%) |
MRCKa | inactive (5.42%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (-2.51%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (4.26%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.33%) |
CaMK1d | inactive (-0.81%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (-1.02%) |
PHKg2 | inactive (-3.95%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (-0.97%) |
CaMK2a | inactive (-3.88%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.15%) |
MAPKAPK2 | inactive (-1.63%) |
MAPKAPK3 | inactive (-1.73%) |
MNK2 | inactive (1.33%) |
MNK1 | inactive (5.25%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.75%) |
PKD1 | inactive (-0.14%) |
PKD2 | inactive (-0.31%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.21%) |
MARK3 | inactive (-0.19%) |
MARK1 | inactive (2.75%) |
QIK | inactive (-6.02%) |
SIK | inactive (-2.47%) |
NuaK1 | inactive (0.95%) |
BRSK1 | inactive (1.31%) |
BRSK2 | inactive (3.56%) |
MELK | inactive (6.1%) |
CHK1 | inactive (0.57%) |
PASK | inactive (-1.38%) |
AMPKa1 | inactive (0.11%) |
AMPKa2 | inactive (0.77%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.44%) |
TSSK1 | inactive (-0.07%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.8%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.29%) |
PIM3 | inactive (1%) |
PIM1 | inactive (1.03%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (-4.92%) |
p38a | inactive (-3.47%) |
p38b | inactive (2.54%) |
p38d | inactive (-1.01%) |
Erk2 | inactive (-3.21%) |
Erk1 | inactive (1.82%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (4.77%) |
GSK3B | inactive (3.59%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.58%) |
MSSK1 | inactive (-1.21%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.31%) |
CLK2 | inactive (-0.67%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (6.29%) |
HIPK4 | inactive (2.71%) |
DYRK1B | inactive (6.95%) |
DYRK1A | inactive (8.89%) |
DYRK2 | inactive (-1.63%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (-0.49%) |