Compound Information
Test on : RBC, Millipore
Compound Name
RBC : 5-[(5-chloro-2-oxo-1H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Millipore : SU11652
Inchikey
Same : XPLJEFSRINKZLC-N
RBC : XPLJEFSRINKZLC-UHFFFAOYSA-N
Millipore : XPLJEFSRINKZLC-ATVHPVEESA-N
ChemSpider
RBC : 21465193
Millipore : 4486265
Pubchem CID
RBC : 24906267
Millipore : 5329103
ChEMBL
RBC : -
Millipore : CHEMBL13485
RBC | Millipore |
| |
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PDK1 | inactive (101.46%) | inactive (78%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AKT1 | inactive (101.92%) | inactive (99%) |
AKT2 | inactive (86.85%) | inactive (91%) |
AKT3 | inactive (84.18%) | inactive (79%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DMPK1 | inactive (101.59%) | inactive (52%) |
MRCKa | inactive (60%) | inactive (118%) |
MRCKb | inactive (96.11%) | inactive (103%) |
ROCK1 | inactive (89.73%) | inactive (101%) |
ROCK2 | inactive (73.54%) | inactive (86%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BARK1 | inactive (103.89%) | - |
BARK2 | inactive (97.83%) | - |
GPRK4 | inactive (80.81%) | - |
GPRK5 | inactive (82.69%) | inactive (68%) |
GPRK6 | active (46.26%) | inactive (68%) |
GPRK7 | inactive (62.24%) | inactive (57%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MSK1 | inactive (59.04%) | inactive (80%) |
MSK2 | inactive (58.96%) | active (42%) |
p70S6K | active (41.75%) | active (24%) |
p70S6Kb | inactive (91.61%) | - |
RSK2 | active (15.1%) | active (11%) |
RSK4 | active (10.47%) | active (14%) |
RSK1 | active (13.06%) | active (9%) |
RSK3 | active (10.02%) | active (11%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKACg | inactive (101.45%) | - |
PRKX | inactive (83.93%) | inactive (63%) |
PKACa | inactive (89.97%) | inactive (81%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKCa | inactive (93.13%) | inactive (100%) |
PKCd | inactive (90.42%) | inactive (95%) |
PKCe | inactive (101.96%) | inactive (99%) |
PKCh | inactive (86.11%) | inactive (110%) |
PKCg | inactive (101.43%) | inactive (94%) |
PKCi | inactive (91.9%) | inactive (84%) |
PKCt | inactive (104.69%) | inactive (102%) |
PKCz | inactive (103.54%) | inactive (103%) |
PKCb | inactive (109.55%) | - |
AGC - PKG
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKG2 | inactive (82.6%) | - |
PKG1 | inactive (64.25%) | - |
AGC - PKN
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKN1 | active (36.49%) | - |
PKN2 | inactive (84.36%) | inactive (52%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SGK1 | active (49.61%) | inactive (59%) |
SGK2 | inactive (62.77%) | inactive (60%) |
SGK3 | inactive (102.55%) | inactive (115%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NDR1 | inactive (95.78%) | - |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ABL1 | active (24.65%) | active (23%) |
ABL2 | active (46.79%) | active (47%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ACK | active (22.62%) | active (25%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ALK | active (3.45%) | active (8%) |
LTK | active (11.57%) | - |
TK - Axl
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AXL | active (25.17%) | active (9%) |
MER | active (11.5%) | active (7%) |
TYRO3 | active (23.21%) | active (24%) |
TK - Src
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BLK | active (15.81%) | active (1%) |
BRK | inactive (51.28%) | inactive (65%) |
SRC | active (26.02%) | active (48%) |
FGR | active (11.48%) | active (8%) |
FRK | inactive (59.3%) | active (31%) |
FYN | active (28.39%) | active (6%) |
HCK | active (34.3%) | active (13%) |
LCK | active (11.8%) | active (12%) |
SRM | inactive (101.75%) | - |
YES | active (5.29%) | active (2%) |
LYN | active (6.34%) | active (2%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
BMX | inactive (99.28%) | inactive (73%) |
BTK | inactive (58.26%) | inactive (83%) |
ITK | active (30.02%) | active (21%) |
TEC | inactive (102.21%) | - |
TXK | inactive (79.52%) | inactive (70%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
KIT | active (28.74%) | active (-1%) |
FLT3 | active (0.78%) | active (1%) |
FMS | active (7.41%) | active (0%) |
PDGFRb | active (9.28%) | active (1%) |
PDGFRa | active (25.86%) | active (2%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CSK | inactive (86.33%) | inactive (99%) |
CTK | inactive (96.77%) | - |
TK - DDR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DDR2 | inactive (104.24%) | inactive (94%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
EGFR | inactive (96.98%) | inactive (107%) |
ErbB2 | inactive (102.32%) | - |
ErbB4 | inactive (86.08%) | inactive (86%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
EphA1 | inactive (89.41%) | inactive (82%) |
EphA2 | inactive (93.49%) | inactive (94%) |
EphA3 | inactive (92.45%) | inactive (94%) |
EphA4 | inactive (87.97%) | inactive (101%) |
EphA5 | inactive (90.37%) | inactive (109%) |
EphA6 | active (45.7%) | - |
EphA7 | inactive (67.14%) | inactive (79%) |
EphA8 | inactive (99.48%) | inactive (100%) |
EphB1 | inactive (60.77%) | inactive (64%) |
EphB2 | inactive (87.5%) | inactive (89%) |
EphB3 | inactive (100.07%) | inactive (129%) |
EphB4 | inactive (76.92%) | inactive (100%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FAK | active (25.84%) | active (15%) |
PYK2 | active (30.46%) | active (15%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FER | active (17.72%) | inactive (79%) |
FES | active (22.11%) | active (14%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FGFR1 | active (20.28%) | active (7%) |
FGFR2 | active (29.28%) | active (14%) |
FGFR3 | active (12.34%) | active (8%) |
FGFR4 | inactive (70.54%) | inactive (101%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FLT1 | active (34.37%) | active (5%) |
FLT4 | active (12.1%) | active (0%) |
KDR | active (13.76%) | active (2%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IGF1R | active (35.22%) | inactive (135%) |
IRR | active (4.33%) | active (13%) |
INSR | active (30.12%) | active (32%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
JAK1 | inactive (65.76%) | - |
JAK2 | inactive (54.05%) | inactive (72%) |
JAK3 | active (39.34%) | inactive (62%) |
TYK2 | active (30.85%) | - |
TK - Musk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MUSK | inactive (63.49%) | active (3%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RET | active (2.47%) | active (-1%) |
TK - Met
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RON | inactive (96.67%) | inactive (91%) |
MET | inactive (77%) | active (45%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ROS | active (43.89%) | inactive (106%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SYK | inactive (59.22%) | inactive (92%) |
ZAP70 | inactive (91.23%) | inactive (116%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TIE2 | inactive (98.18%) | inactive (56%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TRKA | active (8.73%) | active (-1%) |
TRKB | active (8.43%) | active (40%) |
TRKC | active (1.87%) | - |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ALK1 | inactive (88.99%) | - |
ALK2 | inactive (107.79%) | - |
ALK4 | inactive (103.21%) | inactive (126%) |
TGFbR1 | inactive (95.51%) | inactive (101%) |
TGFbR2 | inactive (112.79%) | - |
TKL - RAF
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ARAF | inactive (132.1%) | - |
BRAF | inactive (109%) | - |
RAF1 | inactive (116.83%) | inactive (97%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IRAK1 | active (14.06%) | active (9%) |
IRAK4 | active (22.73%) | active (22%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
LIMK1 | inactive (98.38%) | inactive (99%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
LRRK2 | active (1.44%) | - |
TKL - MLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MLK1 | active (49.57%) | active (24%) |
MLK2 | inactive (82.77%) | - |
MLK3 | active (20.99%) | - |
TAK1 | active (3.51%) | active (4%) |
ZAK | inactive (95.82%) | - |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
RIPK2 | inactive (84.06%) | inactive (62%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NuaK1 | active (2.06%) | active (6%) |
BRSK1 | active (36.48%) | active (6%) |
BRSK2 | inactive (53.66%) | active (29%) |
CHK1 | active (15.15%) | active (24%) |
LKB1 | inactive (80.67%) | inactive (98%) |
MARK1 | active (18.07%) | active (14%) |
MARK3 | active (7.86%) | - |
MARK4 | active (7.19%) | - |
MELK | active (16.69%) | active (8%) |
PASK | inactive (89.65%) | inactive (70%) |
QIK | active (42.68%) | - |
NuaK2 | inactive (70.66%) | - |
MARK2 | active (9.74%) | active (11%) |
AMPKa1 | - | active (7%) |
AMPKa2 | - | active (4%) |
SIK | - | active (31%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMK1a | inactive (75.9%) | inactive (51%) |
CaMK1b | inactive (70.47%) | - |
CaMK1d | inactive (60.22%) | active (42%) |
CaMK1g | active (49.47%) | - |
CaMK4 | inactive (94.99%) | inactive (88%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMK2a | active (3.6%) | - |
CaMK2b | active (27.26%) | active (8%) |
CaMK2d | active (7.25%) | active (3%) |
CaMK2g | active (8.13%) | active (3%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CHK2 | active (6.42%) | active (6%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DAPK1 | active (47.71%) | inactive (75%) |
DAPK2 | inactive (86.67%) | inactive (63%) |
DRAK1 | active (16.09%) | active (3%) |
DAPK3 | inactive (54.3%) | active (44%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DCLK2 | inactive (82.84%) | inactive (68%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAPKAPK2 | inactive (102.94%) | inactive (98%) |
MAPKAPK3 | inactive (100.87%) | inactive (108%) |
MAPKAPK5 | inactive (91.65%) | inactive (97%) |
MNK1 | inactive (75.39%) | - |
MNK2 | inactive (88.8%) | inactive (99%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
smMLCK | active (17.62%) | active (9%) |
skMLCK | active (10%) | - |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PHKg1 | active (3.19%) | - |
PHKg2 | active (16.61%) | active (8%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PIM1 | inactive (91.67%) | inactive (85%) |
PIM2 | inactive (101.3%) | inactive (99%) |
PIM3 | inactive (74.04%) | inactive (92%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PKD1 | active (11.25%) | active (38%) |
PKD3 | active (8.04%) | - |
PKD2 | active (11.95%) | inactive (73%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TSSK1 | active (8.45%) | active (8%) |
TSSK2 | inactive (66.92%) | inactive (62%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
STK33 | active (20.61%) | active (33%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAP3K5 | inactive (98.11%) | inactive (60%) |
MAP3K2 | active (20.08%) | - |
MAP3K3 | active (30.63%) | - |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
COT | inactive (113.12%) | - |
NIK | inactive (118.37%) | - |
STE - STE20
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
GCK | active (8.07%) | active (5%) |
HGK | active (4.33%) | - |
KHS1 | active (0.83%) | - |
LOK | active (7.11%) | active (15%) |
MINK | active (4.4%) | active (9%) |
MST1 | active (2.98%) | active (12%) |
MST2 | active (16.86%) | active (34%) |
MST3 | active (22.18%) | active (8%) |
MST4 | inactive (73.21%) | - |
OSR1 | inactive (80.08%) | - |
PAK1 | inactive (93.44%) | - |
PAK2 | inactive (92.7%) | inactive (110%) |
PAK3 | inactive (93.79%) | inactive (64%) |
PAK4 | inactive (76.71%) | inactive (52%) |
PAK5 | inactive (58.89%) | active (30%) |
PAK6 | inactive (100.54%) | inactive (73%) |
SLK | active (38.05%) | - |
YSK1 | inactive (56.13%) | - |
STLK3 | inactive (81.9%) | - |
TAO1 | inactive (65.85%) | inactive (71%) |
TAO2 | inactive (72.59%) | inactive (89%) |
TAO3 | active (45.5%) | inactive (79%) |
MYO3B | active (41.25%) | - |
STE - STE7
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MAP2K1 | active (33.08%) | active (21%) |
MAP2K2 | active (41.4%) | - |
MAP2K6 | inactive (86.19%) | inactive (66%) |
MAP2K7 | - | inactive (92%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
AurA | inactive (80.33%) | active (47%) |
AurB | active (31.9%) | active (7%) |
AurC | inactive (74.67%) | active (38%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CaMKK1 | active (47.74%) | - |
CaMKK2 | active (48%) | - |
Other - Haspin
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Haspin | inactive (82.89%) | active (43%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
IKKa | inactive (101.57%) | inactive (93%) |
IKKb | inactive (100.87%) | inactive (98%) |
IKKe | active (29.42%) | - |
TBK1 | active (16.27%) | active (15%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
NEK1 | inactive (94.73%) | - |
NEK11 | inactive (83.38%) | inactive (80%) |
NEK2 | inactive (77.19%) | inactive (67%) |
NEK4 | inactive (97.04%) | - |
NEK6 | inactive (97.83%) | inactive (91%) |
NEK7 | inactive (99.32%) | inactive (102%) |
NEK9 | inactive (95.92%) | - |
NEK3 | inactive (93.98%) | inactive (111%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PBK | inactive (103.94%) | - |
Other - PLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PLK1 | inactive (105.12%) | inactive (92%) |
PLK2 | inactive (91.24%) | inactive (98%) |
PLK3 | inactive (89.77%) | inactive (94%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
SgK496 | inactive (104.95%) | - |
Other - NAK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MPSK1 | inactive (72.86%) | - |
Other - TTK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TTK | inactive (59.78%) | - |
Other - ULK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
ULK1 | active (13.58%) | - |
ULK2 | active (43%) | active (23%) |
ULK3 | active (21.57%) | active (17%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Wee1 | inactive (94.79%) | - |
Other - WNK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Wnk2 | inactive (100.84%) | inactive (105%) |
Wnk3 | inactive (86.26%) | inactive (94%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
TLK2 | inactive (79.64%) | inactive (69%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
CK1 | 7 | 6 | 4 |
VRK | 3 | 1 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CK1d | active (49.66%) | active (23%) |
CK1g1 | inactive (69.23%) | inactive (64%) |
CK1g2 | active (45.25%) | active (30%) |
CK1g3 | active (47.67%) | active (42%) |
CK1a | inactive (75.69%) | - |
CK1e | active (46.67%) | - |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
VRK1 | inactive (90.74%) | - |
VRK2 | - | inactive (108%) |
CMGC
CMGC
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
CK2 | 3 | 2 | 2 |
CLK | 4 | 4 | 2 |
DYRK | 10 | 9 | 4 |
MAPK | 14 | 10 | 10 |
GSK | 2 | 2 | 2 |
SRPK | 3 | 3 | 3 |
CMGC - CK2
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CK2a1 | inactive (91.4%) | inactive (86%) |
CK2a2 | inactive (64.26%) | inactive (113%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
CLK1 | active (34.24%) | - |
CLK2 | active (15.77%) | active (9%) |
CLK3 | inactive (101.13%) | inactive (77%) |
CLK4 | active (16.82%) | - |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
DYRK1A | active (47.23%) | - |
DYRK1B | active (47.47%) | - |
DYRK2 | inactive (82.67%) | inactive (78%) |
DYRK3 | inactive (81.76%) | - |
DYRK4 | inactive (97.91%) | - |
HIPK1 | inactive (96.88%) | active (32%) |
HIPK2 | active (20.03%) | active (6%) |
HIPK3 | inactive (50.82%) | active (9%) |
HIPK4 | inactive (61.74%) | - |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
Erk1 | inactive (98.8%) | inactive (91%) |
Erk2 | inactive (97.13%) | inactive (97%) |
JNK3 | inactive (104.47%) | inactive (80%) |
NLK | inactive (100.87%) | inactive (102%) |
p38a | inactive (102.63%) | inactive (82%) |
p38b | inactive (100%) | inactive (95%) |
p38d | inactive (103.6%) | inactive (100%) |
p38g | inactive (96.58%) | inactive (108%) |
JNK1 | inactive (97.23%) | inactive (97%) |
JNK2 | inactive (108.52%) | inactive (111%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
GSK3A | inactive (88.28%) | inactive (104%) |
GSK3B | inactive (93.08%) | inactive (87%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
MSSK1 | inactive (92.82%) | inactive (98%) |
SRPK1 | inactive (95.91%) | inactive (112%) |
SRPK2 | inactive (93.66%) | inactive (98%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC | Millipore |
---|
PDHK | 5 | 1 | - |
Alpha | 6 | - | 1 |
PIKK | 6 | - | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
PDHK1 | inactive (101.46%) | - |
Atypical - Alpha
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
eEF2K | - | inactive (105%) |
Atypical - PIKK
Bioactivity |
---|
Kinase | RBC | Millipore |
---|
FRAP | - | inactive (102%) |