Compound Information
Test on : GPCR
Compound Name : CHEMBL405021
Inchikey : XMBGRSAVBPRZAS-UHFFFAOYSA-N
ChemSpider : 5022059
Pubchem CID : 6539593
ChEMBL : CHEMBL405021
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (7.69%) |
TYK2 | inactive (-4.78%) |
JAK2 | inactive (0.77%) |
JAK3 | inactive (0.16%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.6%) |
FES | inactive (2.53%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (63.75%) |
ABL2 | inactive (31.17%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.74%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (4.88%) |
BTK | inactive (2.12%) |
TXK | inactive (17.72%) |
TEC | inactive (16.38%) |
ITK | inactive (2.12%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (6.62%) |
SRM | inactive (3.11%) |
FRK | inactive (2.17%) |
BLK | inactive (6.79%) |
LCK | inactive (6.66%) |
HCK | inactive (15.82%) |
FGR | inactive (12.81%) |
FYN | inactive (5.27%) |
SRC | inactive (10.72%) |
YES | inactive (5.44%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (3.8%) |
EphA4 | inactive (18.89%) |
EphA3 | inactive (6.3%) |
EphB4 | inactive (4.63%) |
EphB3 | inactive (2.89%) |
EphB2 | inactive (17.15%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (7.93%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (1.22%) |
ZAP70 | inactive (1.7%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (9.93%) |
ALK | inactive (4.86%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (7.64%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.84%) |
IGF1R | inactive (11.25%) |
IRR | inactive (0.58%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (5.94%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (4.91%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (4.46%) |
TRKB | inactive (6.76%) |
TRKC | inactive (7.68%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (5.31%) |
MET | inactive (5.86%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-6.73%) |
MER | inactive (5.12%) |
TYRO3 | inactive (16.09%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (5.93%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (2.95%) |
FGFR2 | inactive (7.98%) |
FGFR3 | inactive (5.96%) |
FGFR4 | inactive (0.83%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.3%) |
KDR | inactive (12.58%) |
FLT4 | inactive (16.92%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.1%) |
KIT | inactive (7.38%) |
FLT3 | inactive (2.82%) |
PDGFRa | inactive (20.39%) |
PDGFRb | inactive (13.32%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.48%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.97%) |
TNK1 | inactive (7.79%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (6.49%) |
ErbB2 | inactive (1.33%) |
ErbB4 | inactive (15.76%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.04%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.29%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (4.2%) |
MST1 | inactive (6.38%) |
MST2 | inactive (6.35%) |
MST4 | inactive (-4.03%) |
HGK | active (74.15%) |
MINK | active (64.52%) |
LOK | inactive (19.94%) |
PAK1 | inactive (7.76%) |
PAK3 | inactive (6.01%) |
PAK2 | inactive (2.41%) |
PAK5 | inactive (-0.04%) |
PAK6 | inactive (-4.61%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.62%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (5.68%) |
CK1g2 | inactive (4.84%) |
CK1g1 | inactive (5.75%) |
CK1g3 | inactive (4.52%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.83%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (3.92%) |
AurC | inactive (9.67%) |
AurA | inactive (13.2%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.2%) |
NEK2 | inactive (6.37%) |
NEK9 | inactive (5.87%) |
NEK7 | inactive (3.1%) |
NEK6 | inactive (-0.52%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (8.06%) |
IKKe | inactive (4.27%) |
IKKb | inactive (3.54%) |
IKKa | inactive (7.25%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (6.67%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (3.52%) |
GPRK6 | inactive (3.48%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (1.36%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (5.56%) |
MSK2 | inactive (1.76%) |
RSK1 | inactive (1.81%) |
RSK2 | inactive (0.07%) |
RSK4 | inactive (3.11%) |
RSK3 | inactive (3.36%) |
p70S6K | inactive (1.27%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.68%) |
AKT1 | inactive (-0.63%) |
AKT3 | inactive (2.94%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (5.38%) |
SGK3 | inactive (3.95%) |
SGK2 | inactive (1.73%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.77%) |
PKCg | inactive (1.52%) |
PKCa | inactive (1.87%) |
PKCt | inactive (1.97%) |
PKCi | inactive (3.51%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.57%) |
PKG1 | inactive (3.14%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.63%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.05%) |
ROCK2 | inactive (0.78%) |
MRCKb | inactive (0.02%) |
MRCKa | inactive (-1.04%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (3.79%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.05%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1.21%) |
CaMK1d | inactive (-0.38%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (7.18%) |
PHKg2 | inactive (4.5%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.53%) |
CaMK2a | inactive (2.25%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.86%) |
MAPKAPK2 | inactive (2.8%) |
MAPKAPK3 | inactive (4.31%) |
MNK2 | inactive (10.18%) |
MNK1 | inactive (31.45%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (6.47%) |
PKD1 | inactive (5.64%) |
PKD2 | inactive (5.1%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (5.77%) |
MARK3 | inactive (9.09%) |
MARK1 | inactive (9.42%) |
QIK | inactive (12.8%) |
SIK | inactive (9.28%) |
NuaK1 | inactive (2.6%) |
BRSK1 | inactive (21%) |
BRSK2 | inactive (19.74%) |
MELK | inactive (3.69%) |
CHK1 | inactive (5.48%) |
PASK | inactive (-1.15%) |
AMPKa1 | inactive (4.22%) |
AMPKa2 | inactive (7.53%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.6%) |
TSSK1 | inactive (2.02%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (7.04%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.64%) |
PIM3 | inactive (-2.34%) |
PIM1 | inactive (0.46%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (7.19%) |
p38a | inactive (11.15%) |
p38b | inactive (6.34%) |
p38d | inactive (5.86%) |
Erk2 | inactive (6.01%) |
Erk1 | inactive (4.97%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (32.69%) |
GSK3B | inactive (28.38%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.41%) |
MSSK1 | inactive (-0.2%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.33%) |
CLK2 | inactive (2.28%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (0.72%) |
HIPK4 | inactive (3.44%) |
DYRK1B | inactive (3.5%) |
DYRK1A | inactive (6.14%) |
DYRK2 | inactive (4.68%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (6.38%) |