Compound Information
Test on : GPCR
Compound Name : CHEMBL330422
Inchikey : XKOQKLFWCLUSAU-UHFFFAOYSA-N
ChemSpider : 23184695
Pubchem CID : 44329036
ChEMBL : CHEMBL330422
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (7.32%) |
TYK2 | inactive (-4.71%) |
JAK2 | inactive (1.42%) |
JAK3 | inactive (-0.11%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (7.14%) |
FES | inactive (3.24%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (6.5%) |
ABL2 | inactive (2.99%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (8.66%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (4.95%) |
BTK | inactive (0.09%) |
TXK | inactive (2.52%) |
TEC | inactive (5.09%) |
ITK | inactive (2.24%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (6.89%) |
SRM | inactive (-0.42%) |
FRK | inactive (1.02%) |
BLK | inactive (2.11%) |
LCK | inactive (1.46%) |
HCK | inactive (9.14%) |
FGR | inactive (2.78%) |
FYN | inactive (1.8%) |
SRC | inactive (7.94%) |
YES | inactive (8.81%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-0.04%) |
EphA4 | inactive (14.67%) |
EphA3 | inactive (5.33%) |
EphB4 | inactive (8.07%) |
EphB3 | inactive (2%) |
EphB2 | inactive (10.66%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (18.04%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-1.12%) |
ZAP70 | inactive (-0.3%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.36%) |
ALK | inactive (5.43%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (2.72%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (3.28%) |
IGF1R | inactive (4.78%) |
IRR | inactive (2.39%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (3.08%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.41%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.02%) |
TRKB | inactive (6.67%) |
TRKC | inactive (5.91%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-1.06%) |
MET | inactive (10.55%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-5.39%) |
MER | inactive (7.18%) |
TYRO3 | inactive (5.81%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (1.73%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-2.05%) |
FGFR2 | inactive (6.49%) |
FGFR3 | inactive (5.67%) |
FGFR4 | inactive (0.38%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (3.27%) |
KDR | inactive (9.32%) |
FLT4 | inactive (0.88%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (3.2%) |
KIT | inactive (10.67%) |
FLT3 | inactive (5.56%) |
PDGFRa | inactive (14.4%) |
PDGFRb | inactive (20.72%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.36%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (2.83%) |
TNK1 | inactive (10.79%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (6.58%) |
ErbB2 | inactive (6.66%) |
ErbB4 | inactive (12.29%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.47%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (8.68%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (1.59%) |
MST1 | inactive (10.36%) |
MST2 | inactive (9.48%) |
MST4 | inactive (1.34%) |
HGK | inactive (17.53%) |
MINK | inactive (15.76%) |
LOK | inactive (8.57%) |
PAK1 | inactive (7.1%) |
PAK3 | inactive (3.76%) |
PAK2 | inactive (2.52%) |
PAK5 | inactive (1.35%) |
PAK6 | inactive (-2.04%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (5.25%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | active (73.43%) |
CK1g2 | inactive (5.84%) |
CK1g1 | inactive (8.74%) |
CK1g3 | inactive (10.23%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.42%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (4.96%) |
AurC | inactive (-3.16%) |
AurA | inactive (9.26%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.44%) |
NEK2 | inactive (5.72%) |
NEK9 | inactive (8.58%) |
NEK7 | inactive (3.39%) |
NEK6 | inactive (5.15%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (7.57%) |
IKKe | inactive (9.51%) |
IKKb | inactive (6.36%) |
IKKa | inactive (6.82%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (2.05%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (7.73%) |
GPRK6 | inactive (6.12%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.68%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.7%) |
MSK2 | inactive (4.02%) |
RSK1 | inactive (6.04%) |
RSK2 | inactive (3.09%) |
RSK4 | inactive (1.96%) |
RSK3 | inactive (4.29%) |
p70S6K | inactive (1.98%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.3%) |
AKT1 | inactive (1.07%) |
AKT3 | inactive (2.14%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (6.71%) |
SGK3 | inactive (3.95%) |
SGK2 | inactive (5.93%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.5%) |
PKCg | inactive (5.6%) |
PKCa | inactive (6.57%) |
PKCt | inactive (5.13%) |
PKCi | inactive (1.08%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.54%) |
PKG1 | inactive (4.89%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (5.03%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (4.39%) |
ROCK2 | inactive (8.52%) |
MRCKb | inactive (0.28%) |
MRCKa | inactive (2.92%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.51%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.48%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-5.99%) |
CaMK1d | inactive (-1.38%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (5.88%) |
PHKg2 | inactive (7.31%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.99%) |
CaMK2a | inactive (3.86%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (4.06%) |
MAPKAPK2 | inactive (2.43%) |
MAPKAPK3 | inactive (37.24%) |
MNK2 | inactive (8.42%) |
MNK1 | inactive (15.95%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (10.97%) |
PKD1 | inactive (14.62%) |
PKD2 | inactive (14.8%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.05%) |
MARK3 | inactive (6.04%) |
MARK1 | inactive (7.7%) |
QIK | inactive (16.62%) |
SIK | inactive (6.87%) |
NuaK1 | inactive (0.83%) |
BRSK1 | inactive (3.71%) |
BRSK2 | inactive (6.29%) |
MELK | inactive (5.49%) |
CHK1 | inactive (6.89%) |
PASK | inactive (0.93%) |
AMPKa1 | inactive (6.22%) |
AMPKa2 | inactive (3.88%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (4.33%) |
TSSK1 | inactive (6.56%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (5.18%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (2.65%) |
PIM3 | inactive (5.22%) |
PIM1 | inactive (1.55%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (37.32%) |
p38a | active (86.34%) |
p38b | active (52.52%) |
p38d | inactive (4.31%) |
Erk2 | inactive (6.12%) |
Erk1 | inactive (6.51%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (5.09%) |
GSK3B | inactive (7.21%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (3.27%) |
MSSK1 | inactive (1.7%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (3.15%) |
CLK2 | inactive (2.41%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (7.67%) |
HIPK4 | inactive (4.16%) |
DYRK1B | inactive (1.43%) |
DYRK1A | inactive (3.78%) |
DYRK2 | inactive (3.9%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (13.23%) |