Compound Information
Test on : RBC
Compound Name : Cdk2 Inhibitor IV, NU6140
Inchikey : XHEQSRJCJTWWAH-UHFFFAOYSA-N
ChemSpider : 8377969
Pubchem CID : 10202471
ChEMBL : CHEMBL1802728
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (69.14%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (98.75%) |
AKT2 | inactive (92.04%) |
AKT3 | inactive (101.13%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (105.13%) |
MRCKa | inactive (90.72%) |
MRCKb | inactive (99.3%) |
ROCK1 | inactive (54.86%) |
ROCK2 | active (39.76%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (92.59%) |
BARK2 | inactive (92.7%) |
GPRK4 | inactive (92.99%) |
GPRK5 | inactive (98.78%) |
GPRK6 | inactive (99.53%) |
GPRK7 | inactive (102.67%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (89.84%) |
MSK2 | inactive (79.81%) |
p70S6K | inactive (89.55%) |
p70S6Kb | inactive (101.8%) |
RSK2 | active (17.57%) |
RSK4 | active (46.19%) |
RSK1 | inactive (57.14%) |
RSK3 | active (30.95%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | inactive (93.38%) |
PKACa | inactive (93.73%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (82.49%) |
PKCd | inactive (76.73%) |
PKCe | inactive (76.61%) |
PKCh | inactive (86.68%) |
PKCg | inactive (94.52%) |
PKCi | inactive (97.24%) |
PKCt | inactive (97.89%) |
PKCz | inactive (95.81%) |
PKCb | inactive (95.03%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (80.03%) |
PKG1 | inactive (89.78%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (78.89%) |
PKN2 | inactive (91.84%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (84.69%) |
SGK2 | inactive (94.44%) |
SGK3 | inactive (97.15%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (67.09%) |
ABL2 | inactive (67.78%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | active (21.42%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (74.91%) |
LTK | inactive (66.08%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (80.85%) |
MER | inactive (71.63%) |
TYRO3 | inactive (90.43%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (60.85%) |
BRK | active (30.65%) |
SRC | inactive (72.76%) |
FGR | inactive (54.16%) |
FRK | inactive (115.62%) |
FYN | inactive (62.56%) |
HCK | inactive (63.07%) |
LCK | active (39.78%) |
SRM | inactive (84.72%) |
YES | active (15.38%) |
LYN | inactive (78.2%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | active (42.9%) |
BTK | active (37.07%) |
ITK | inactive (57.34%) |
TEC | inactive (63.03%) |
TXK | active (46.02%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | active (40.74%) |
FLT3 | active (10.33%) |
FMS | active (5.73%) |
PDGFRb | inactive (54.58%) |
PDGFRa | inactive (66.59%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (83.1%) |
CTK | inactive (95.58%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (108.9%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (88.45%) |
ErbB2 | inactive (99.41%) |
ErbB4 | inactive (90.95%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (90.21%) |
EphA2 | inactive (90.64%) |
EphA3 | inactive (99.95%) |
EphA4 | inactive (86.7%) |
EphA5 | inactive (94.96%) |
EphA6 | - |
EphA7 | inactive (72.84%) |
EphA8 | inactive (92.08%) |
EphB1 | inactive (75.38%) |
EphB2 | inactive (93.67%) |
EphB3 | inactive (99.46%) |
EphB4 | inactive (84.97%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (76.9%) |
PYK2 | active (48.69%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | active (42.05%) |
FES | inactive (63.2%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (72.85%) |
FGFR2 | inactive (76.62%) |
FGFR3 | inactive (66.91%) |
FGFR4 | inactive (94.36%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (83.99%) |
FLT4 | active (25.93%) |
KDR | inactive (76.5%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | active (28.41%) |
IRR | inactive (80.81%) |
INSR | inactive (92.75%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (51.78%) |
JAK2 | active (4.21%) |
JAK3 | active (6.39%) |
TYK2 | active (4.96%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (77.49%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | active (7.65%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (103.39%) |
MET | inactive (85.33%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (69.89%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (61.07%) |
ZAP70 | inactive (93.97%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (95.38%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (81.42%) |
TRKB | inactive (54.32%) |
TRKC | active (32.27%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (106.19%) |
ALK2 | inactive (98.83%) |
ALK4 | inactive (100.77%) |
TGFbR1 | inactive (100.15%) |
TGFbR2 | inactive (75.42%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (95.39%) |
BRAF | inactive (96.82%) |
RAF1 | inactive (86.31%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (93.78%) |
IRAK4 | inactive (92.36%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | active (35.15%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | active (2.21%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | active (3.8%) |
MLK2 | active (15.2%) |
MLK3 | active (5.55%) |
TAK1 | inactive (57.07%) |
ZAK | inactive (91.39%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (97.21%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | active (3.67%) |
BRSK1 | inactive (84.04%) |
BRSK2 | inactive (82.5%) |
CHK1 | inactive (66.05%) |
LKB1 | inactive (85.15%) |
MARK1 | inactive (82.69%) |
MARK3 | inactive (85.37%) |
MARK4 | inactive (93.81%) |
MELK | inactive (76.3%) |
PASK | inactive (103.14%) |
QIK | inactive (75.27%) |
NuaK2 | active (23.05%) |
MARK2 | inactive (75.31%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (85.56%) |
CaMK1b | inactive (117.22%) |
CaMK1d | inactive (100.73%) |
CaMK1g | inactive (96.1%) |
CaMK4 | inactive (97.68%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (105.1%) |
CaMK2b | inactive (97.59%) |
CaMK2d | inactive (94.54%) |
CaMK2g | inactive (95.24%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (71.35%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (81.55%) |
DAPK2 | inactive (91.71%) |
DRAK1 | inactive (59.77%) |
DAPK3 | inactive (98.4%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (97.27%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (99.16%) |
MAPKAPK3 | inactive (103.26%) |
MAPKAPK5 | inactive (87.82%) |
MNK1 | inactive (97.51%) |
MNK2 | inactive (89.31%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (91.6%) |
skMLCK | inactive (94.69%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (85.91%) |
PHKg2 | inactive (96.6%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (95.55%) |
PIM2 | inactive (104.93%) |
PIM3 | inactive (108.75%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (62.65%) |
PKD3 | inactive (66.51%) |
PKD2 | inactive (67.02%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | active (15.3%) |
TSSK2 | inactive (87.42%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (67.25%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (96.94%) |
MAP3K2 | active (25.28%) |
MAP3K3 | active (47.29%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (101.45%) |
NIK | inactive (131.92%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (59.67%) |
HGK | inactive (85.89%) |
KHS1 | inactive (77.98%) |
LOK | inactive (57.3%) |
MINK | inactive (88.48%) |
MST1 | active (46.31%) |
MST2 | inactive (62.09%) |
MST3 | inactive (84.51%) |
MST4 | inactive (84.91%) |
OSR1 | inactive (99.05%) |
PAK1 | inactive (93.82%) |
PAK2 | inactive (90.75%) |
PAK3 | inactive (87.67%) |
PAK4 | inactive (51.48%) |
PAK5 | active (49.05%) |
PAK6 | inactive (95.46%) |
SLK | inactive (71.23%) |
YSK1 | inactive (85.15%) |
STLK3 | inactive (91.47%) |
TAO1 | inactive (57.86%) |
TAO2 | inactive (65.97%) |
TAO3 | inactive (74.22%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (94.1%) |
MAP2K2 | inactive (94.04%) |
MAP2K6 | inactive (93.11%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | active (3.03%) |
AurB | active (30.13%) |
AurC | active (20.73%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (96.81%) |
CaMKK2 | inactive (97.46%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (94.15%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (103.3%) |
IKKb | inactive (97.28%) |
IKKe | inactive (77.94%) |
TBK1 | active (25.4%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (53.13%) |
NEK11 | inactive (132.01%) |
NEK2 | inactive (91.39%) |
NEK4 | inactive (87.95%) |
NEK6 | inactive (101.2%) |
NEK7 | inactive (102.88%) |
NEK9 | inactive (81.9%) |
NEK3 | inactive (69.44%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (115.56%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (91.42%) |
PLK2 | inactive (98.22%) |
PLK3 | inactive (98.1%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (106.14%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | active (33.61%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | active (47.83%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (77.71%) |
ULK2 | inactive (84.91%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (110.18%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (88.59%) |
Wnk3 | inactive (80.6%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (102.03%) |
CK1g1 | inactive (68.5%) |
CK1g2 | inactive (59.78%) |
CK1g3 | inactive (61.66%) |
CK1a | inactive (104.03%) |
CK1e | inactive (95.61%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (93.09%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (87.44%) |
CK2a2 | inactive (90.93%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (74.14%) |
CLK2 | active (40.64%) |
CLK3 | inactive (84.12%) |
CLK4 | active (44.22%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (91.88%) |
DYRK1B | inactive (90.2%) |
DYRK2 | inactive (98.15%) |
DYRK3 | inactive (97.59%) |
DYRK4 | inactive (93.59%) |
HIPK1 | inactive (104.33%) |
HIPK2 | inactive (92.43%) |
HIPK3 | inactive (96.38%) |
HIPK4 | inactive (96.45%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (101.27%) |
Erk2 | inactive (105.54%) |
JNK3 | inactive (108.33%) |
NLK | inactive (94.46%) |
p38a | inactive (94.74%) |
p38b | inactive (85.53%) |
p38d | inactive (95.32%) |
p38g | inactive (99.41%) |
JNK1 | inactive (51.05%) |
JNK2 | inactive (60.83%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (80.35%) |
GSK3B | inactive (84.96%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (68.05%) |
SRPK1 | inactive (91.72%) |
SRPK2 | inactive (87.75%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (69.14%) |