Compound Information
Test on : GPCR
Compound Name : SB-376719
Inchikey : XCYIIVRZXLZJER-UHFFFAOYSA-N
ChemSpider : 5021919
Pubchem CID : 6539453
ChEMBL : CHEMBL156263
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (19.07%) |
TYK2 | inactive (-1.53%) |
JAK2 | inactive (2.77%) |
JAK3 | active (53.93%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (10.23%) |
FES | inactive (3.59%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (21.89%) |
ABL2 | inactive (10.1%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (5.49%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (3.52%) |
BTK | inactive (1.15%) |
TXK | inactive (5.43%) |
TEC | inactive (5.84%) |
ITK | inactive (1.95%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (3.7%) |
SRM | inactive (4.8%) |
FRK | inactive (1.76%) |
BLK | inactive (12.8%) |
LCK | inactive (22.81%) |
HCK | inactive (16.16%) |
FGR | inactive (8.83%) |
FYN | inactive (13.06%) |
SRC | inactive (27.36%) |
YES | inactive (20.28%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.6%) |
EphA4 | inactive (13.39%) |
EphA3 | inactive (4.46%) |
EphB4 | inactive (2.07%) |
EphB3 | inactive (3.76%) |
EphB2 | inactive (12.15%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (13.13%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.56%) |
ZAP70 | inactive (1.94%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (3.44%) |
ALK | inactive (7.95%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.7%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.91%) |
IGF1R | inactive (4.06%) |
IRR | inactive (3.19%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (9.17%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (6.34%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.37%) |
TRKB | inactive (6.04%) |
TRKC | inactive (5.53%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (7.21%) |
MET | inactive (7.23%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-1.8%) |
MER | inactive (1.51%) |
TYRO3 | inactive (3.3%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (12.02%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (2.56%) |
FGFR2 | inactive (6.4%) |
FGFR3 | inactive (3.74%) |
FGFR4 | inactive (2.28%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (3.09%) |
KDR | inactive (21.09%) |
FLT4 | inactive (4.56%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (4.75%) |
KIT | inactive (4.82%) |
FLT3 | inactive (2.33%) |
PDGFRa | inactive (13.76%) |
PDGFRb | inactive (9.91%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (10.51%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.97%) |
TNK1 | inactive (16.11%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.39%) |
ErbB2 | inactive (2.5%) |
ErbB4 | inactive (10.39%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.37%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (4.42%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (13.27%) |
MST1 | inactive (44.01%) |
MST2 | inactive (34.19%) |
MST4 | inactive (15.31%) |
HGK | inactive (10.63%) |
MINK | inactive (7.59%) |
LOK | active (73.2%) |
PAK1 | inactive (8.18%) |
PAK3 | inactive (3.76%) |
PAK2 | inactive (1.82%) |
PAK5 | inactive (2.53%) |
PAK6 | inactive (2.59%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.81%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.21%) |
CK1g2 | inactive (2.19%) |
CK1g1 | inactive (3.07%) |
CK1g3 | inactive (3.26%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (1.42%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (5.05%) |
AurC | inactive (-1.48%) |
AurA | inactive (8.25%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.4%) |
NEK2 | inactive (4.08%) |
NEK9 | inactive (9.03%) |
NEK7 | inactive (4.14%) |
NEK6 | inactive (2.63%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (7.18%) |
IKKe | inactive (7.53%) |
IKKb | inactive (4.05%) |
IKKa | inactive (0.8%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (9.73%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-0.25%) |
GPRK6 | inactive (6.4%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.62%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-2.33%) |
MSK2 | inactive (3.19%) |
RSK1 | inactive (4.91%) |
RSK2 | inactive (4.83%) |
RSK4 | inactive (11.1%) |
RSK3 | inactive (11.34%) |
p70S6K | inactive (2.68%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.36%) |
AKT1 | inactive (1.46%) |
AKT3 | inactive (3.11%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.01%) |
SGK3 | inactive (5.07%) |
SGK2 | inactive (1.68%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (7.31%) |
PKCg | inactive (3.89%) |
PKCa | inactive (9.05%) |
PKCt | inactive (7.77%) |
PKCi | inactive (0.39%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.24%) |
PKG1 | inactive (3.55%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.75%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (0.72%) |
ROCK2 | inactive (4.34%) |
MRCKb | inactive (6.81%) |
MRCKa | inactive (17.09%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (-1.64%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (3.12%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.64%) |
CaMK1d | inactive (1.96%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (8.01%) |
PHKg2 | inactive (4.8%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (14.93%) |
CaMK2a | inactive (5.89%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.14%) |
MAPKAPK2 | inactive (-1.51%) |
MAPKAPK3 | inactive (0.18%) |
MNK2 | inactive (5.14%) |
MNK1 | inactive (8.76%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3.43%) |
PKD1 | inactive (4.49%) |
PKD2 | inactive (3.26%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (13.19%) |
MARK3 | inactive (28.33%) |
MARK1 | inactive (15.16%) |
QIK | inactive (27.82%) |
SIK | inactive (18.2%) |
NuaK1 | inactive (7.2%) |
BRSK1 | inactive (7.08%) |
BRSK2 | inactive (12%) |
MELK | inactive (2.36%) |
CHK1 | inactive (-2.38%) |
PASK | inactive (0.53%) |
AMPKa1 | inactive (5.01%) |
AMPKa2 | inactive (5.49%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.76%) |
TSSK1 | inactive (2.98%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-4.37%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.14%) |
PIM3 | inactive (1.17%) |
PIM1 | inactive (1.26%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (4.12%) |
p38a | inactive (13.59%) |
p38b | inactive (5.91%) |
p38d | inactive (3.46%) |
Erk2 | inactive (5.04%) |
Erk1 | inactive (2.72%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (69.15%) |
GSK3B | active (67.11%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.68%) |
MSSK1 | inactive (9.64%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (8.2%) |
CLK2 | inactive (49.2%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (0.24%) |
HIPK4 | inactive (9.56%) |
DYRK1B | inactive (21.97%) |
DYRK1A | inactive (23.48%) |
DYRK2 | inactive (3.03%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (9.2%) |