Compound Information
Test on : RBC
Compound Name : Aloisine
Inchikey : WVMANZPBOBRWCB-UHFFFAOYSA-N
ChemSpider : 2875180
Pubchem CID : 3641059
ChEMBL : CHEMBL306498
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (102.13%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (112.75%) |
AKT2 | inactive (93.79%) |
AKT3 | inactive (101.98%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (84.27%) |
MRCKa | inactive (99.67%) |
MRCKb | inactive (92.54%) |
ROCK1 | inactive (99.86%) |
ROCK2 | inactive (97.25%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (78.49%) |
BARK2 | inactive (95.6%) |
GPRK4 | inactive (96.75%) |
GPRK5 | inactive (104.78%) |
GPRK6 | inactive (88.35%) |
GPRK7 | inactive (94.09%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (104.21%) |
MSK2 | inactive (89.43%) |
p70S6K | inactive (108.38%) |
p70S6Kb | inactive (99.7%) |
RSK2 | inactive (88.04%) |
RSK4 | inactive (78.22%) |
RSK1 | inactive (89.82%) |
RSK3 | inactive (93.02%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | inactive (102.36%) |
PKACa | inactive (96.64%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (92.72%) |
PKCd | inactive (92.79%) |
PKCe | inactive (101.51%) |
PKCh | inactive (102.74%) |
PKCg | inactive (94.41%) |
PKCi | inactive (72.84%) |
PKCt | inactive (107.35%) |
PKCz | inactive (93.94%) |
PKCb | inactive (106.33%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (93.92%) |
PKG1 | inactive (92.73%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (89.11%) |
PKN2 | inactive (88.63%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (88.44%) |
SGK2 | inactive (116.02%) |
SGK3 | inactive (98.61%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (83.38%) |
ABL2 | inactive (70.5%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (51.24%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (96.67%) |
LTK | inactive (83.91%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (110.3%) |
MER | inactive (92.63%) |
TYRO3 | inactive (98.6%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (96.67%) |
BRK | active (30.42%) |
SRC | inactive (58.84%) |
FGR | inactive (57.14%) |
FRK | inactive (86.5%) |
FYN | inactive (61.26%) |
HCK | inactive (94.37%) |
LCK | inactive (84.96%) |
SRM | inactive (96.72%) |
YES | active (45.73%) |
LYN | inactive (85.48%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (82.21%) |
BTK | inactive (64.74%) |
ITK | inactive (99.44%) |
TEC | inactive (133.94%) |
TXK | inactive (72.66%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (82.86%) |
FLT3 | active (47.82%) |
FMS | active (37.67%) |
PDGFRb | inactive (95.9%) |
PDGFRa | inactive (90.25%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (87.02%) |
CTK | inactive (100.92%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (94.28%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (102.52%) |
ErbB2 | inactive (96.44%) |
ErbB4 | inactive (109.15%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (67.88%) |
EphA2 | inactive (87.88%) |
EphA3 | inactive (91.89%) |
EphA4 | inactive (85.52%) |
EphA5 | inactive (91.62%) |
EphA6 | - |
EphA7 | inactive (97.96%) |
EphA8 | inactive (102.94%) |
EphB1 | inactive (76.03%) |
EphB2 | inactive (88.84%) |
EphB3 | inactive (99.8%) |
EphB4 | inactive (89.5%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (81.73%) |
PYK2 | inactive (100.12%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (59.77%) |
FES | inactive (66.01%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (83.3%) |
FGFR2 | inactive (89.51%) |
FGFR3 | inactive (86.81%) |
FGFR4 | inactive (92.48%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (102.79%) |
FLT4 | inactive (81.07%) |
KDR | inactive (88.76%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (83.9%) |
IRR | inactive (83.15%) |
INSR | inactive (97.55%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (67.06%) |
JAK2 | inactive (77.93%) |
JAK3 | inactive (92.78%) |
TYK2 | active (38.78%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (95.43%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (56.34%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (103.82%) |
MET | inactive (86.8%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | active (37.47%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | active (47.47%) |
ZAP70 | inactive (74.23%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (96.3%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (108.78%) |
TRKB | inactive (73.42%) |
TRKC | inactive (84.41%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (76.98%) |
ALK2 | inactive (86.94%) |
ALK4 | inactive (111.64%) |
TGFbR1 | inactive (95.04%) |
TGFbR2 | inactive (74.78%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (94.07%) |
BRAF | inactive (99.37%) |
RAF1 | inactive (99.87%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (64.31%) |
IRAK4 | inactive (163.16%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (65.31%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (83.01%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | active (39.78%) |
MLK2 | inactive (82.7%) |
MLK3 | active (39.4%) |
TAK1 | inactive (90.64%) |
ZAK | inactive (83.6%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (70.96%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | active (24.97%) |
BRSK1 | inactive (89.05%) |
BRSK2 | inactive (90.76%) |
CHK1 | inactive (93.09%) |
LKB1 | inactive (74.49%) |
MARK1 | inactive (92.92%) |
MARK3 | inactive (91.25%) |
MARK4 | inactive (88.28%) |
MELK | inactive (84.41%) |
PASK | inactive (97.58%) |
QIK | inactive (98.35%) |
NuaK2 | inactive (68.03%) |
MARK2 | inactive (83.05%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (90.94%) |
CaMK1b | inactive (120.03%) |
CaMK1d | inactive (97.94%) |
CaMK1g | inactive (101.8%) |
CaMK4 | inactive (97.58%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (99.97%) |
CaMK2b | inactive (97.65%) |
CaMK2d | inactive (93.27%) |
CaMK2g | inactive (106.64%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (72.82%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (90.64%) |
DAPK2 | inactive (100.62%) |
DRAK1 | inactive (95.54%) |
DAPK3 | inactive (101.76%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (101.28%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (90.22%) |
MAPKAPK3 | inactive (98.57%) |
MAPKAPK5 | inactive (95.27%) |
MNK1 | inactive (97.65%) |
MNK2 | inactive (99.26%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (96.85%) |
skMLCK | inactive (101.74%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (89.4%) |
PHKg2 | inactive (106.3%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (96.99%) |
PIM2 | inactive (114.55%) |
PIM3 | inactive (90.92%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (92.88%) |
PKD3 | inactive (88.47%) |
PKD2 | inactive (101.06%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (65.31%) |
TSSK2 | inactive (93.68%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (84.61%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (94.98%) |
MAP3K2 | inactive (90.88%) |
MAP3K3 | inactive (99.77%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (98.22%) |
NIK | inactive (104.68%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (65.1%) |
HGK | inactive (66.47%) |
KHS1 | inactive (63.82%) |
LOK | inactive (95.37%) |
MINK | inactive (84.44%) |
MST1 | inactive (82.2%) |
MST2 | inactive (87.02%) |
MST3 | inactive (87.26%) |
MST4 | inactive (75.78%) |
OSR1 | inactive (101.62%) |
PAK1 | inactive (83.65%) |
PAK2 | inactive (97.5%) |
PAK3 | inactive (106.11%) |
PAK4 | inactive (106.56%) |
PAK5 | inactive (88.08%) |
PAK6 | inactive (96.83%) |
SLK | inactive (76.19%) |
YSK1 | inactive (90.31%) |
STLK3 | inactive (77.83%) |
TAO1 | inactive (87.03%) |
TAO2 | inactive (90.05%) |
TAO3 | inactive (102.92%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (88.66%) |
MAP2K2 | inactive (79.45%) |
MAP2K6 | inactive (96.02%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | active (25.45%) |
AurB | inactive (64.5%) |
AurC | inactive (55.83%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (105.08%) |
CaMKK2 | inactive (79.15%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (79.98%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (97.26%) |
IKKb | inactive (101.56%) |
IKKe | inactive (100.26%) |
TBK1 | inactive (81.42%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (86.88%) |
NEK11 | inactive (93.62%) |
NEK2 | inactive (115.16%) |
NEK4 | inactive (81.28%) |
NEK6 | inactive (110.62%) |
NEK7 | inactive (106.72%) |
NEK9 | inactive (106.43%) |
NEK3 | inactive (99.1%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (80.58%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (104.27%) |
PLK2 | inactive (94.94%) |
PLK3 | inactive (91.53%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (97.56%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (58.71%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (87.9%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (87.87%) |
ULK2 | inactive (107.96%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (85.93%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (112.26%) |
Wnk3 | inactive (88.44%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (94.74%) |
CK1g1 | inactive (93.32%) |
CK1g2 | inactive (92.55%) |
CK1g3 | inactive (89.21%) |
CK1a | inactive (92.89%) |
CK1e | inactive (108.92%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (95.54%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (97.78%) |
CK2a2 | inactive (94.11%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (101.95%) |
CLK2 | inactive (85.32%) |
CLK3 | inactive (116.4%) |
CLK4 | inactive (73.15%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (102.17%) |
DYRK1B | inactive (94.53%) |
DYRK2 | inactive (92.86%) |
DYRK3 | inactive (96.14%) |
DYRK4 | inactive (97.66%) |
HIPK1 | inactive (109.05%) |
HIPK2 | inactive (108.97%) |
HIPK3 | inactive (99.86%) |
HIPK4 | inactive (118.75%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (110.69%) |
Erk2 | inactive (103.33%) |
JNK3 | inactive (97.22%) |
NLK | inactive (88.44%) |
p38a | inactive (112.06%) |
p38b | inactive (100.21%) |
p38d | inactive (99.1%) |
p38g | inactive (102.1%) |
JNK1 | inactive (74.54%) |
JNK2 | inactive (84.8%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (55.76%) |
GSK3B | inactive (70.16%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (97.94%) |
SRPK1 | inactive (100.34%) |
SRPK2 | inactive (105.1%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (102.13%) |