Compound Information
Test on : GPCR
Compound Name : GW799251X
Inchikey : WRXRFFUVXFNKGG-UHFFFAOYSA-N
ChemSpider : 9815630
Pubchem CID : 11640889
ChEMBL : CHEMBL381604
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (2.27%) |
TYK2 | inactive (-1.09%) |
JAK2 | inactive (1.57%) |
JAK3 | inactive (4.42%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.48%) |
FES | inactive (4.65%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (9.58%) |
ABL2 | inactive (3.33%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (3.09%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (8.65%) |
BTK | inactive (7.04%) |
TXK | inactive (8.58%) |
TEC | inactive (13.57%) |
ITK | inactive (3.09%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (3.74%) |
SRM | inactive (-3.68%) |
FRK | inactive (0.85%) |
BLK | inactive (5.98%) |
LCK | inactive (8.03%) |
HCK | inactive (10.18%) |
FGR | inactive (4.81%) |
FYN | inactive (2.19%) |
SRC | inactive (7.62%) |
YES | inactive (5.85%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.27%) |
EphA4 | inactive (-0.84%) |
EphA3 | inactive (3.27%) |
EphB4 | inactive (2.68%) |
EphB3 | inactive (4.02%) |
EphB2 | inactive (7.89%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (14.25%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.63%) |
ZAP70 | inactive (3.29%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (2.75%) |
ALK | inactive (6.28%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (16.19%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (4.44%) |
IGF1R | inactive (4.12%) |
IRR | inactive (1.12%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (4.7%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (5.94%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (9.29%) |
TRKB | inactive (11.27%) |
TRKC | inactive (9.94%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (9.09%) |
MET | inactive (8.47%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (1.72%) |
MER | inactive (9.35%) |
TYRO3 | inactive (3.66%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (5.76%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (4.02%) |
FGFR2 | inactive (8.42%) |
FGFR3 | inactive (5.62%) |
FGFR4 | inactive (-2.31%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (3.36%) |
KDR | inactive (10.64%) |
FLT4 | inactive (0.33%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.18%) |
KIT | inactive (2.68%) |
FLT3 | inactive (3.87%) |
PDGFRa | inactive (15.5%) |
PDGFRb | inactive (11.62%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.5%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.21%) |
TNK1 | inactive (8.89%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | active (76.32%) |
ErbB2 | inactive (-8.09%) |
ErbB4 | inactive (24.82%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.48%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.72%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (-0.42%) |
MST1 | inactive (10.37%) |
MST2 | inactive (7.32%) |
MST4 | inactive (-8.32%) |
HGK | inactive (5.46%) |
MINK | inactive (6.41%) |
LOK | inactive (11.45%) |
PAK1 | inactive (3.97%) |
PAK3 | inactive (3.37%) |
PAK2 | inactive (2.31%) |
PAK5 | inactive (-3.56%) |
PAK6 | inactive (1.07%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.4%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (5.01%) |
CK1g2 | inactive (3.89%) |
CK1g1 | inactive (4.16%) |
CK1g3 | inactive (3.02%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.68%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (13.23%) |
AurC | inactive (10.11%) |
AurA | inactive (15.17%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.18%) |
NEK2 | inactive (5.98%) |
NEK9 | inactive (1.53%) |
NEK7 | inactive (3.35%) |
NEK6 | inactive (-0.89%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (9.39%) |
IKKe | inactive (6.36%) |
IKKb | inactive (-0.17%) |
IKKa | inactive (2.46%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (14.19%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (1.2%) |
GPRK6 | inactive (-4.58%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (4.39%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.83%) |
MSK2 | inactive (4.41%) |
RSK1 | inactive (2.85%) |
RSK2 | inactive (0.81%) |
RSK4 | inactive (1%) |
RSK3 | inactive (2.85%) |
p70S6K | inactive (1.35%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.54%) |
AKT1 | inactive (0.92%) |
AKT3 | inactive (1.85%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.96%) |
SGK3 | inactive (3.95%) |
SGK2 | inactive (3.69%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-0.12%) |
PKCg | inactive (4.21%) |
PKCa | inactive (1.81%) |
PKCt | inactive (1.22%) |
PKCi | inactive (3.2%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (7.43%) |
PKG1 | inactive (5.43%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.22%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (3.74%) |
ROCK2 | inactive (4.22%) |
MRCKb | inactive (2.38%) |
MRCKa | inactive (-0.95%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.77%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.82%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.61%) |
CaMK1d | inactive (2.27%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (27.54%) |
PHKg2 | inactive (2.05%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (8.79%) |
CaMK2a | inactive (5.08%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.01%) |
MAPKAPK2 | inactive (1.43%) |
MAPKAPK3 | inactive (4.95%) |
MNK2 | inactive (8.39%) |
MNK1 | inactive (13.98%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (5.74%) |
PKD1 | inactive (6.75%) |
PKD2 | inactive (5.62%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (7.4%) |
MARK3 | inactive (11.21%) |
MARK1 | inactive (10.44%) |
QIK | inactive (8.28%) |
SIK | inactive (6.42%) |
NuaK1 | inactive (9.68%) |
BRSK1 | inactive (8.92%) |
BRSK2 | inactive (10.83%) |
MELK | inactive (5.11%) |
CHK1 | inactive (7.61%) |
PASK | inactive (-3.04%) |
AMPKa1 | inactive (5.37%) |
AMPKa2 | inactive (6.02%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.18%) |
TSSK1 | inactive (1.86%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (5.3%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.29%) |
PIM3 | inactive (-1.09%) |
PIM1 | inactive (1.16%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (4.23%) |
p38a | inactive (7.42%) |
p38b | inactive (4.43%) |
p38d | inactive (4.65%) |
Erk2 | inactive (4.87%) |
Erk1 | inactive (1.04%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (14.3%) |
GSK3B | inactive (10.46%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.48%) |
MSSK1 | inactive (-0.42%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (3.1%) |
CLK2 | inactive (14.17%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (6.94%) |
HIPK4 | inactive (8.43%) |
DYRK1B | inactive (4.87%) |
DYRK1A | inactive (10.75%) |
DYRK2 | inactive (4.89%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (2.69%) |