Compound Information
Test on : GPCR
Compound Name : GW852849X
Inchikey : WRWFZZDBIJLBIJ-UHFFFAOYSA-N
ChemSpider : 24715484
Pubchem CID : 25263092
ChEMBL : CHEMBL514162
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (5.86%) |
TYK2 | inactive (2.41%) |
JAK2 | inactive (0.34%) |
JAK3 | inactive (4.86%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (8.52%) |
FES | inactive (0.38%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (32.19%) |
ABL2 | inactive (21.05%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.61%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (4.4%) |
BTK | inactive (1.14%) |
TXK | inactive (13.2%) |
TEC | inactive (7.65%) |
ITK | inactive (3.19%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (7.77%) |
SRM | inactive (7.95%) |
FRK | inactive (2.45%) |
BLK | inactive (23.15%) |
LCK | inactive (18.97%) |
HCK | inactive (27.15%) |
FGR | inactive (19.05%) |
FYN | inactive (23.53%) |
SRC | inactive (20.88%) |
YES | inactive (17.87%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-1.31%) |
EphA4 | inactive (7.32%) |
EphA3 | inactive (0.98%) |
EphB4 | inactive (3.38%) |
EphB3 | inactive (1.6%) |
EphB2 | inactive (7.08%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (6.28%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (1.86%) |
ZAP70 | inactive (0.47%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (4.03%) |
ALK | inactive (5.8%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (29.16%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (7.12%) |
IGF1R | inactive (2.52%) |
IRR | inactive (0.06%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (0.75%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (21.22%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.92%) |
TRKB | inactive (13.69%) |
TRKC | inactive (20.42%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (13.33%) |
MET | inactive (19.66%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (2.44%) |
MER | inactive (8.5%) |
TYRO3 | inactive (9.65%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (60.83%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (8.43%) |
FGFR2 | inactive (13.22%) |
FGFR3 | inactive (13.16%) |
FGFR4 | inactive (2.76%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (9.81%) |
KDR | active (53.86%) |
FLT4 | active (54.79%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (23.68%) |
KIT | inactive (15.57%) |
FLT3 | inactive (3.62%) |
PDGFRa | active (90.47%) |
PDGFRb | active (86.49%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (26.95%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (7.05%) |
TNK1 | active (63.16%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (8.81%) |
ErbB2 | inactive (2.47%) |
ErbB4 | inactive (9.17%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.8%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (2.15%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (30.83%) |
MST1 | inactive (46.17%) |
MST2 | inactive (42.44%) |
MST4 | inactive (-3.28%) |
HGK | active (56.61%) |
MINK | active (51.02%) |
LOK | active (99%) |
PAK1 | inactive (1.43%) |
PAK3 | inactive (1.37%) |
PAK2 | inactive (-1.31%) |
PAK5 | inactive (0.31%) |
PAK6 | inactive (-7.5%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.16%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (0.67%) |
CK1g2 | inactive (1.68%) |
CK1g1 | inactive (1.8%) |
CK1g3 | inactive (2.71%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | active (96.3%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (29.9%) |
AurC | inactive (40.53%) |
AurA | inactive (23.5%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (15.49%) |
NEK2 | inactive (37.26%) |
NEK9 | active (55.47%) |
NEK7 | inactive (1.21%) |
NEK6 | inactive (-3.5%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (28.66%) |
IKKe | inactive (2.71%) |
IKKb | inactive (1.01%) |
IKKa | inactive (5.14%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (0.54%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (9.44%) |
GPRK6 | inactive (5.7%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (6.11%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-5.25%) |
MSK2 | inactive (3.02%) |
RSK1 | inactive (3.5%) |
RSK2 | inactive (7.69%) |
RSK4 | inactive (17.18%) |
RSK3 | inactive (8.47%) |
p70S6K | inactive (0.64%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.92%) |
AKT1 | inactive (-0.21%) |
AKT3 | inactive (-1.17%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (1.67%) |
SGK3 | inactive (0.41%) |
SGK2 | inactive (0.22%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.19%) |
PKCg | inactive (2.36%) |
PKCa | inactive (1.42%) |
PKCt | inactive (0.66%) |
PKCi | inactive (0.82%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.84%) |
PKG1 | inactive (3.55%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-3.1%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (0.6%) |
ROCK2 | inactive (2.11%) |
MRCKb | inactive (1.67%) |
MRCKa | inactive (2.18%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (-0.53%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (4.65%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.41%) |
CaMK1d | inactive (3.64%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (5.84%) |
PHKg2 | inactive (1.21%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (2.88%) |
CaMK2a | inactive (-0.06%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.67%) |
MAPKAPK2 | inactive (-3.53%) |
MAPKAPK3 | inactive (-2.78%) |
MNK2 | inactive (7.9%) |
MNK1 | inactive (7.42%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.33%) |
PKD1 | inactive (0.57%) |
PKD2 | inactive (1.64%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (9.04%) |
MARK3 | inactive (9.99%) |
MARK1 | inactive (9.28%) |
QIK | inactive (26.55%) |
SIK | inactive (28.03%) |
NuaK1 | active (58.62%) |
BRSK1 | inactive (40.65%) |
BRSK2 | inactive (48.64%) |
MELK | inactive (8.87%) |
CHK1 | inactive (-4.25%) |
PASK | inactive (-0.88%) |
AMPKa1 | inactive (10.7%) |
AMPKa2 | inactive (3.59%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.63%) |
TSSK1 | inactive (4.67%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-14.96%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (4.79%) |
PIM3 | inactive (8.63%) |
PIM1 | inactive (2.71%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (4.49%) |
p38a | inactive (18.45%) |
p38b | inactive (4.07%) |
p38d | inactive (0.78%) |
Erk2 | inactive (1.08%) |
Erk1 | inactive (1.75%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (9.18%) |
GSK3B | inactive (9.93%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.23%) |
MSSK1 | inactive (-1.33%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (4.39%) |
CLK2 | inactive (3.23%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (5.3%) |
HIPK4 | inactive (45.13%) |
DYRK1B | inactive (0.48%) |
DYRK1A | inactive (4.21%) |
DYRK2 | inactive (2.53%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (9.54%) |