Compound Information
Test on : GPCR
Compound Name : GW811761X
Inchikey : WNKSRDBBYKDORB-UHFFFAOYSA-N
ChemSpider : 5021848
Pubchem CID : 6539382
ChEMBL : CHEMBL183993
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (5.28%) |
TYK2 | - |
JAK2 | inactive (0.53%) |
JAK3 | inactive (-0.21%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (7.63%) |
FES | inactive (2.59%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (7.89%) |
ABL2 | inactive (8.28%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (1.6%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (1.94%) |
BTK | inactive (1.18%) |
TXK | inactive (3.47%) |
TEC | inactive (4.44%) |
ITK | inactive (4.47%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (0.97%) |
SRM | inactive (-1.56%) |
FRK | inactive (0.63%) |
BLK | inactive (3.22%) |
LCK | inactive (7.3%) |
HCK | inactive (6.8%) |
FGR | inactive (5.2%) |
FYN | inactive (4.94%) |
SRC | inactive (3.76%) |
YES | inactive (3.08%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.67%) |
EphA4 | inactive (9.91%) |
EphA3 | inactive (5.76%) |
EphB4 | inactive (2.81%) |
EphB3 | inactive (2.33%) |
EphB2 | inactive (9.64%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (3.33%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-6.38%) |
ZAP70 | inactive (2.78%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (1.96%) |
ALK | inactive (3.1%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (15%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.46%) |
IGF1R | inactive (1.57%) |
IRR | inactive (1%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (6.02%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (1.27%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (0.26%) |
TRKB | inactive (2.11%) |
TRKC | inactive (3.18%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-3.11%) |
MET | inactive (3.51%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-0.78%) |
MER | inactive (3.35%) |
TYRO3 | inactive (2.7%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (5.18%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (7.08%) |
FGFR2 | inactive (7.12%) |
FGFR3 | inactive (5.74%) |
FGFR4 | inactive (-0.95%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.9%) |
KDR | inactive (7.57%) |
FLT4 | inactive (3.46%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (14.07%) |
KIT | inactive (17.83%) |
FLT3 | inactive (5.14%) |
PDGFRa | inactive (27.26%) |
PDGFRb | inactive (20.48%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7.44%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (0.5%) |
TNK1 | inactive (14.7%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.97%) |
ErbB2 | inactive (2.54%) |
ErbB4 | inactive (6.85%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.01%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (1.64%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (6.12%) |
MST1 | inactive (3.98%) |
MST2 | inactive (6.48%) |
MST4 | inactive (0.13%) |
HGK | inactive (4.83%) |
MINK | inactive (7.19%) |
LOK | inactive (12.91%) |
PAK1 | inactive (3.75%) |
PAK3 | inactive (2.39%) |
PAK2 | inactive (-0.6%) |
PAK5 | inactive (-0.74%) |
PAK6 | inactive (-3.51%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (0.44%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (0.35%) |
CK1g2 | inactive (3.07%) |
CK1g1 | inactive (3.1%) |
CK1g3 | inactive (1.86%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (1.39%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (9.87%) |
AurC | inactive (12.51%) |
AurA | inactive (7.68%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.31%) |
NEK2 | inactive (1.02%) |
NEK9 | inactive (4.9%) |
NEK7 | inactive (0.03%) |
NEK6 | inactive (2.66%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (13.14%) |
IKKe | inactive (12.12%) |
IKKb | inactive (3.66%) |
IKKa | inactive (6.76%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (4.11%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (0.86%) |
GPRK6 | inactive (-2.59%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (-2.64%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-1.09%) |
MSK2 | inactive (-0.01%) |
RSK1 | inactive (0.51%) |
RSK2 | inactive (1.88%) |
RSK4 | inactive (-0.99%) |
RSK3 | inactive (0.76%) |
p70S6K | inactive (-0.17%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.35%) |
AKT1 | inactive (0.31%) |
AKT3 | inactive (4.77%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (0.13%) |
SGK3 | inactive (2.4%) |
SGK2 | inactive (0.87%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-0.29%) |
PKCg | inactive (2.94%) |
PKCa | inactive (0.74%) |
PKCt | inactive (0.7%) |
PKCi | inactive (0.72%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (0.29%) |
PKG1 | inactive (1.15%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.76%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (-1%) |
ROCK2 | inactive (-0.05%) |
MRCKb | inactive (-1.84%) |
MRCKa | inactive (-1.89%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (1.92%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (3.6%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1%) |
CaMK1d | inactive (1.1%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.48%) |
PHKg2 | inactive (3.92%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (0.44%) |
CaMK2a | inactive (-2.29%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.41%) |
MAPKAPK2 | inactive (-0.24%) |
MAPKAPK3 | inactive (1.86%) |
MNK2 | inactive (3.49%) |
MNK1 | inactive (4.31%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3.58%) |
PKD1 | inactive (3.21%) |
PKD2 | inactive (1.84%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.8%) |
MARK3 | inactive (0.96%) |
MARK1 | inactive (3.98%) |
QIK | inactive (3.43%) |
SIK | inactive (3.82%) |
NuaK1 | inactive (7.44%) |
BRSK1 | inactive (4.56%) |
BRSK2 | inactive (2.66%) |
MELK | inactive (3.63%) |
CHK1 | inactive (3.51%) |
PASK | inactive (0.46%) |
AMPKa1 | inactive (2.09%) |
AMPKa2 | inactive (2.74%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.22%) |
TSSK1 | inactive (3.46%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.54%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.33%) |
PIM3 | inactive (-1.96%) |
PIM1 | inactive (-1.35%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (1.35%) |
p38a | inactive (1.48%) |
p38b | inactive (2.69%) |
p38d | inactive (0.75%) |
Erk2 | inactive (3.31%) |
Erk1 | inactive (2.69%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (46.07%) |
GSK3B | inactive (33.64%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.22%) |
MSSK1 | inactive (1.62%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (6.13%) |
CLK2 | active (94.28%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (70.04%) |
HIPK4 | inactive (46.18%) |
DYRK1B | inactive (20.98%) |
DYRK1A | inactive (6.48%) |
DYRK2 | inactive (0.78%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (7.82%) |