Compound Information
Test on : GPCR
Compound Name : GW811168X
Inchikey : WKJFLAJZSWRICW-FOKLQQMPSA-N
ChemSpider : 7879067
Pubchem CID : 9604948
ChEMBL : CHEMBL66292
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (6.92%) |
TYK2 | inactive (1.37%) |
JAK2 | inactive (11.53%) |
JAK3 | inactive (5.53%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (2.49%) |
FES | inactive (0.07%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (72.99%) |
ABL2 | active (61.67%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (18.19%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (30.74%) |
BTK | inactive (-3.39%) |
TXK | inactive (12.45%) |
TEC | inactive (10.42%) |
ITK | inactive (0.29%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (26.8%) |
SRM | inactive (17.77%) |
FRK | inactive (3.05%) |
BLK | inactive (38.36%) |
LCK | active (73.92%) |
HCK | active (55.7%) |
FGR | active (64.02%) |
FYN | active (69.82%) |
SRC | active (77.37%) |
YES | active (57.39%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (1.45%) |
EphA4 | inactive (11.74%) |
EphA3 | inactive (-1.2%) |
EphB4 | inactive (6.93%) |
EphB3 | inactive (-2.08%) |
EphB2 | inactive (11.49%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (5.9%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-1.66%) |
ZAP70 | inactive (1.31%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (2.05%) |
ALK | inactive (-1.6%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (27.18%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.06%) |
IGF1R | inactive (-5.27%) |
IRR | inactive (0.63%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (7.83%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (23.28%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (5.3%) |
TRKB | inactive (19.34%) |
TRKC | inactive (22.32%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (44.28%) |
MET | inactive (47.61%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (1.34%) |
MER | inactive (28.3%) |
TYRO3 | inactive (22.39%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (30.73%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (0.92%) |
FGFR2 | inactive (4.85%) |
FGFR3 | inactive (4.08%) |
FGFR4 | inactive (-1.16%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (18.81%) |
KDR | active (66.43%) |
FLT4 | inactive (31.4%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (22.46%) |
KIT | active (61.65%) |
FLT3 | inactive (27.85%) |
PDGFRa | active (77.81%) |
PDGFRb | active (78.14%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (31.43%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.96%) |
TNK1 | inactive (20.01%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (22.65%) |
ErbB2 | inactive (3.96%) |
ErbB4 | inactive (7.9%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.12%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (16.37%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (0.9%) |
MST1 | inactive (4.3%) |
MST2 | inactive (2.91%) |
MST4 | inactive (2.58%) |
HGK | active (59.4%) |
MINK | active (50.32%) |
LOK | inactive (16.3%) |
PAK1 | inactive (3.02%) |
PAK3 | inactive (1.53%) |
PAK2 | inactive (-0.47%) |
PAK5 | inactive (10.06%) |
PAK6 | inactive (5.24%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (1.58%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (5.91%) |
CK1g2 | inactive (-0.73%) |
CK1g1 | inactive (-0.99%) |
CK1g3 | inactive (-2.43%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.92%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (42.41%) |
AurC | inactive (12.22%) |
AurA | inactive (28.41%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (5.16%) |
NEK2 | inactive (1.84%) |
NEK9 | inactive (1.23%) |
NEK7 | inactive (2.28%) |
NEK6 | inactive (-0.32%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (7.99%) |
IKKe | inactive (8.64%) |
IKKb | inactive (-0.15%) |
IKKa | inactive (-0.62%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (-19.19%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (0.56%) |
GPRK6 | inactive (-1.78%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (5.75%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-0.55%) |
MSK2 | inactive (2.04%) |
RSK1 | inactive (0.53%) |
RSK2 | inactive (0.98%) |
RSK4 | inactive (3.2%) |
RSK3 | inactive (4.48%) |
p70S6K | inactive (5.85%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-2.73%) |
AKT1 | inactive (-2.91%) |
AKT3 | inactive (-3.66%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (10.12%) |
SGK3 | inactive (2.6%) |
SGK2 | inactive (4.33%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.85%) |
PKCg | inactive (3.18%) |
PKCa | inactive (-0.59%) |
PKCt | inactive (1.19%) |
PKCi | inactive (0.98%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.79%) |
PKG1 | inactive (1.69%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.61%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.16%) |
ROCK2 | inactive (1.85%) |
MRCKb | inactive (0.16%) |
MRCKa | inactive (-0.45%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (0.05%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-3.25%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.23%) |
CaMK1d | inactive (0.51%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (2.63%) |
PHKg2 | inactive (2.21%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (4.11%) |
CaMK2a | inactive (1.01%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.26%) |
MAPKAPK2 | inactive (-0.87%) |
MAPKAPK3 | inactive (-1.31%) |
MNK2 | inactive (23.95%) |
MNK1 | inactive (34.18%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (-2.38%) |
PKD1 | inactive (-1.45%) |
PKD2 | inactive (-2.8%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.52%) |
MARK3 | inactive (4.26%) |
MARK1 | inactive (4.83%) |
QIK | inactive (29.94%) |
SIK | inactive (26%) |
NuaK1 | inactive (37.42%) |
BRSK1 | active (52.46%) |
BRSK2 | active (60.79%) |
MELK | inactive (4.85%) |
CHK1 | inactive (-1.03%) |
PASK | inactive (0.02%) |
AMPKa1 | inactive (2%) |
AMPKa2 | inactive (4.43%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.31%) |
TSSK1 | inactive (-0.61%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-2.35%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-2.5%) |
PIM3 | inactive (2.23%) |
PIM1 | inactive (1.73%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (4.9%) |
p38a | inactive (4.7%) |
p38b | inactive (1.99%) |
p38d | inactive (6.79%) |
Erk2 | inactive (1.93%) |
Erk1 | inactive (1.55%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (80.61%) |
GSK3B | active (78.96%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.02%) |
MSSK1 | inactive (1%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (13.51%) |
CLK2 | inactive (18.37%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (64.34%) |
HIPK4 | active (60.58%) |
DYRK1B | inactive (47.3%) |
DYRK1A | active (64.28%) |
DYRK2 | inactive (24.95%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (39.12%) |